locus-tag	class	description
N1236_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N1236_00010	COG0592	DNA-directed DNA polymerase activity
N1236_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N1236_00030	COG0187	DNA topoisomerase II activity
N1236_00035	COG1192	Involved in chromosome partitioning
N1236_00040	COG1475	DNA binding
N1236_00055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N1236_00070	COG2814	Major facilitator Superfamily
N1236_00080	COG2373	Large extracellular alpha-helical protein
N1236_00090	COG2720	vancomycin resistance protein
N1236_00110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N1236_00120	COG0674	pyruvate-flavodoxin oxidoreductase activity
N1236_00125	COG1013	pyruvate-flavodoxin oxidoreductase activity
N1236_00160	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N1236_00180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N1236_00185	COG1802	Transcriptional regulator
N1236_00190	COG2608	mercury ion transmembrane transporter activity
N1236_00200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N1236_00225	COG4717	serine-type aminopeptidase activity
N1236_00230	COG0791	NLP P60 protein
N1236_00235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N1236_00245	COG2959	enzyme of heme biosynthesis
N1236_00270	COG1078	dGTPase activity
N1236_00305	COG3872	metal-dependent enzyme
N1236_00310	COG2890	protein-(glutamine-N5) methyltransferase activity
N1236_00320	COG4656	Part of a membrane complex involved in electron transport
N1236_00325	COG4658	electron transport chain
N1236_00330	COG4659	FMN binding
N1236_00335	COG4660	Part of a membrane complex involved in electron transport
N1236_00340	COG4657	Part of a membrane complex involved in electron transport
N1236_00345	COG2878	Part of a membrane complex involved in electron transport
N1236_00375	COG1349	DNA-binding transcription factor activity
N1236_00380	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N1236_00385	COG3959	Transketolase, thiamine diphosphate binding domain
N1236_00390	COG3958	Transketolase
N1236_00395	COG1063	alcohol dehydrogenase
N1236_00400	COG1879	ABC-type sugar transport system periplasmic component
N1236_00405	COG1129	ABC transporter
N1236_00415	COG0406	alpha-ribazole phosphatase activity
N1236_00425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N1236_00430	COG1164	Oligoendopeptidase f
N1236_00440	COG3693	PFAM glycoside hydrolase, family 10
N1236_00450	COG0590	tRNA wobble adenosine to inosine editing
N1236_00465	COG0662	Cupin 2, conserved barrel domain protein
N1236_00475	COG1609	Transcriptional regulator
N1236_00500	COG0668	transmembrane transport
N1236_00510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N1236_00520	COG0590	tRNA wobble adenosine to inosine editing
N1236_00525	COG0028	Belongs to the TPP enzyme family
N1236_00530	COG0440	acetolactate synthase activity
N1236_00535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N1236_00540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N1236_00550	COG1191	sigma factor activity
N1236_00565	COG1959	2 iron, 2 sulfur cluster binding
N1236_00570	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N1236_00580	COG0181	hydroxymethylbilane synthase activity
N1236_00590	COG0113	porphobilinogen synthase activity
N1236_00595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N1236_00600	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N1236_00605	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N1236_00610	COG4208	sulfate ABC transporter
N1236_00620	COG0175	sulfate reduction
N1236_00625	COG0175	sulfate reduction
N1236_00640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N1236_00665	COG1595	DNA-templated transcription, initiation
N1236_00690	COG3534	alpha-L-arabinofuranosidase
N1236_00700	COG5297	Belongs to the glycosyl hydrolase family 6
N1236_00710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N1236_00720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N1236_00735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N1236_00740	COG1216	Glycosyl transferase, family 2
N1236_00745	COG1088	dTDP-glucose 4,6-dehydratase activity
N1236_00755	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
N1236_00775	COG3328	transposase activity
N1236_00785	COG1032	radical SAM domain protein
N1236_00820	COG1116	anion transmembrane transporter activity
N1236_00825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N1236_00830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N1236_00840	COG2954	triphosphatase activity
N1236_00860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N1236_00865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N1236_00870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N1236_00880	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
N1236_00880	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
N1236_00895	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
N1236_00905	COG3693	PFAM glycoside hydrolase, family 10
N1236_00920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N1236_00925	COG0428	transporter
N1236_00930	COG0009	L-threonylcarbamoyladenylate synthase
N1236_00940	COG0698	ribose 5-phosphate isomerase
N1236_00945	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N1236_00950	COG2131	deaminase
N1236_00955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N1236_00960	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N1236_00965	COG0356	it plays a direct role in the translocation of protons across the membrane
N1236_00970	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N1236_00975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N1236_00980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N1236_00985	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N1236_00990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N1236_00995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N1236_01000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N1236_01020	COG3266	domain, Protein
N1236_01020	COG2911	Protein conserved in bacteria
N1236_01020	COG1361	Conserved repeat domain
N1236_01030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N1236_01035	COG2385	sporulation resulting in formation of a cellular spore
N1236_01045	COG1609	Transcriptional regulator
N1236_01055	COG4786	Flagellar basal body rod
N1236_01080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N1236_01085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N1236_01090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N1236_01095	COG2088	sporulation resulting in formation of a cellular spore
N1236_01100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N1236_01110	COG0193	aminoacyl-tRNA hydrolase activity
N1236_01115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N1236_01120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N1236_01125	COG1917	Cupin 2, conserved barrel domain protein
N1236_01125	COG2207	Transcriptional regulator
N1236_01130	COG0259	pyridoxamine-phosphate oxidase activity
N1236_01135	COG0728	peptidoglycan biosynthetic process
N1236_01155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N1236_01160	COG2089	acid synthase
N1236_01170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N1236_01175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N1236_01180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N1236_01190	COG1181	Belongs to the D-alanine--D-alanine ligase family
N1236_01195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N1236_01225	COG4464	protein tyrosine phosphatase activity
N1236_01230	COG2002	toxin-antitoxin pair type II binding
N1236_01235	COG3956	TIGRFAM MazG family protein
N1236_01245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N1236_01265	COG1098	S1 RNA binding domain
N1236_01285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N1236_01365	COG4191	Histidine kinase
N1236_01380	COG0793	Belongs to the peptidase S41A family
N1236_01425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N1236_01430	COG0849	cell division
N1236_01435	COG1607	acyl-coa hydrolase
N1236_01440	COG2244	polysaccharide biosynthetic process
N1236_01450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N1236_01460	COG0110	maltose O-acetyltransferase activity
N1236_01485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N1236_01485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N1236_01490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N1236_01495	COG0864	Transcriptional regulator
N1236_01500	COG2337	Toxic component of a toxin-antitoxin (TA) module
N1236_01515	COG0438	transferase activity, transferring glycosyl groups
N1236_01520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N1236_01525	COG3959	Transketolase, thiamine diphosphate binding domain
N1236_01530	COG3958	Transketolase
N1236_01535	COG1131	(ABC) transporter
N1236_01555	COG3949	Membrane
N1236_01570	COG0129	dihydroxy-acid dehydratase activity
N1236_01575	COG0028	Belongs to the TPP enzyme family
N1236_01590	COG0250	Participates in transcription elongation, termination and antitermination
N1236_01595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N1236_01600	COG0081	regulation of translation
N1236_01605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N1236_01615	COG0085	RNA polymerase activity
N1236_01620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N1236_01625	COG1358	cellular component organization or biogenesis
N1236_01630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N1236_01635	COG0049	tRNA binding
N1236_01640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N1236_01645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N1236_01665	COG2720	vancomycin resistance protein
N1236_01675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N1236_01680	COG0322	excinuclease ABC activity
N1236_01690	COG0544	peptidyl-prolyl cis-trans isomerase activity
N1236_01695	COG0740	serine-type endopeptidase activity
N1236_01700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N1236_01705	COG1067	ATP-dependent peptidase activity
N1236_01705	COG0470	DNA polymerase III
N1236_01710	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N1236_01715	COG0741	lytic transglycosylase activity
N1236_01730	COG0613	PHP domain protein
N1236_01735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N1236_01755	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N1236_01780	COG3263	regulation of cellular component size
N1236_01790	COG2207	Transcriptional regulator
N1236_01790	COG3708	Transcriptional regulator
N1236_01795	COG4733	cellulase activity
N1236_01795	COG4447	cellulose binding
N1236_01800	COG5297	Belongs to the glycosyl hydrolase family 6
N1236_01835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N1236_01840	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
N1236_01850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N1236_01885	COG1361	Conserved repeat domain
N1236_01885	COG2911	Protein conserved in bacteria
N1236_01885	COG3266	domain, Protein
N1236_01895	COG5012	cobalamin binding
N1236_01900	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N1236_01925	COG1116	anion transmembrane transporter activity
N1236_01930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N1236_01935	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
N1236_01945	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N1236_01955	COG0674	pyruvate-flavodoxin oxidoreductase activity
N1236_01960	COG1013	pyruvate-flavodoxin oxidoreductase activity
N1236_01970	COG0251	oxidation-reduction process
N1236_01975	COG0626	cystathionine gamma-synthase activity
N1236_01980	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N1236_01985	COG1151	hydroxylamine reductase activity
N1236_01995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N1236_02000	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
N1236_02010	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
N1236_02015	COG1609	Transcriptional regulator
N1236_02030	COG4124	Belongs to the glycosyl hydrolase 26 family
N1236_02035	COG4447	cellulose binding
N1236_02035	COG4733	cellulase activity
N1236_02045	COG2205	protein histidine kinase activity
N1236_02055	COG0835	chemotaxis
N1236_02060	COG0784	Response regulator, receiver
N1236_02060	COG0643	Histidine kinase
N1236_02060	COG2198	Histidine kinase
N1236_02070	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N1236_02075	COG2201	protein-glutamate methylesterase activity
N1236_02090	COG1253	flavin adenine dinucleotide binding
N1236_02105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
N1236_02115	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
N1236_02145	COG0124	histidyl-tRNA synthetase
N1236_02150	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N1236_02155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N1236_02160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N1236_02165	COG0131	Imidazoleglycerol-phosphate dehydratase
N1236_02170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N1236_02175	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N1236_02180	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N1236_02185	COG0107	imidazoleglycerol-phosphate synthase activity
N1236_02200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N1236_02205	COG0459	protein refolding
N1236_02220	COG3858	chitin binding
N1236_02230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N1236_02235	COG1366	Belongs to the anti-sigma-factor antagonist family
N1236_02240	COG2172	sigma factor antagonist activity
N1236_02245	COG1191	sigma factor activity
N1236_02280	COG0051	transcription antitermination factor activity, RNA binding
N1236_02285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N1236_02290	COG0088	Forms part of the polypeptide exit tunnel
N1236_02295	COG0089	rRNA binding
N1236_02300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N1236_02305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N1236_02310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N1236_02315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N1236_02320	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N1236_02325	COG0255	Belongs to the universal ribosomal protein uL29 family
N1236_02330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N1236_02335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N1236_02340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N1236_02345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N1236_02350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N1236_02355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N1236_02360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N1236_02365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N1236_02370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N1236_02375	COG1841	ribosomal large subunit assembly
N1236_02380	COG0200	Binds to the 23S rRNA
N1236_02385	COG0201	protein transport
N1236_02390	COG0563	adenylate kinase activity
N1236_02405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N1236_02410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N1236_02415	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N1236_02420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N1236_02425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N1236_02430	COG0202	RNA polymerase activity
N1236_02435	COG0203	ribosomal protein L17
N1236_02440	COG1122	ATPase activity
N1236_02445	COG2813	Specifically methylates the guanine in position
N1236_02450	COG1122	ATPase activity
N1236_02455	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N1236_02460	COG1940	carbohydrate kinase activity
N1236_02465	COG0101	tRNA pseudouridine synthase activity
N1236_02470	COG1329	Transcriptional regulator
N1236_02475	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N1236_02480	COG4555	ABC transporter
N1236_02485	COG1668	transmembrane transport
N1236_02490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N1236_02490	COG4191	Histidine kinase
N1236_02495	COG3290	protein histidine kinase activity
N1236_02500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N1236_02510	COG0442	prolyl-tRNA aminoacylation
N1236_02515	COG2340	Cysteine-rich secretory protein family
N1236_02520	COG2273	Hydrolase Family 16
N1236_02525	COG3250	beta-galactosidase activity
N1236_02570	COG4166	transmembrane transport
N1236_02575	COG4608	Belongs to the ABC transporter superfamily
N1236_02580	COG0444	Belongs to the ABC transporter superfamily
N1236_02585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N1236_02590	COG0601	transmembrane transport
N1236_02610	COG1725	Transcriptional regulator
N1236_02615	COG1131	(ABC) transporter
N1236_02635	COG1489	DNA binding
N1236_02640	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N1236_02645	COG1191	sigma factor activity
N1236_02685	COG0840	transmembrane signaling receptor activity
N1236_02735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N1236_02765	COG0693	protein deglycase activity
N1236_02775	COG1132	(ABC) transporter
N1236_02785	COG0306	phosphate transporter
N1236_02805	COG1388	LysM domain
N1236_02810	COG1376	ErfK ybiS ycfS ynhG family protein
N1236_02850	COG5520	Belongs to the glycosyl hydrolase 30 family
N1236_02860	COG0409	Hydrogenase expression formation protein
N1236_02870	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
N1236_02890	COG3261	NADH dehydrogenase
N1236_02890	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
N1236_02900	COG3260	NADH ubiquinone oxidoreductase 20
N1236_02910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N1236_02910	COG2111	Na H antiporter
N1236_02920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N1236_02925	COG0372	Belongs to the citrate synthase family
N1236_02930	COG0076	glutamate decarboxylase activity
N1236_02935	COG0835	chemotaxis
N1236_02940	COG0840	transmembrane signaling receptor activity
N1236_02965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N1236_02970	COG0840	transmembrane signaling receptor activity
N1236_03005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N1236_03025	COG0768	penicillin binding
N1236_03030	COG2003	Belongs to the UPF0758 family
N1236_03050	COG3328	transposase activity
N1236_03100	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
N1236_03115	COG3458	cephalosporin-C deacetylase activity
N1236_03145	COG1131	(ABC) transporter
N1236_03155	COG5002	protein histidine kinase activity
N1236_03160	COG0745	RESPONSE REGULATOR receiver
N1236_03180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N1236_03185	COG0561	phosphatase activity
N1236_03190	COG2304	oxidoreductase activity
N1236_03200	COG2911	Protein conserved in bacteria
N1236_03205	COG3266	domain, Protein
N1236_03205	COG2911	Protein conserved in bacteria
N1236_03205	COG3266	domain, Protein
N1236_03205	COG2911	Protein conserved in bacteria
N1236_03205	COG1361	Conserved repeat domain
N1236_03205	COG1361	Conserved repeat domain
N1236_03210	COG1361	Conserved repeat domain
N1236_03215	COG1361	Conserved repeat domain
N1236_03235	COG0116	Belongs to the methyltransferase superfamily
N1236_03245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N1236_03270	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
N1236_03285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N1236_03315	COG0463	Glycosyl transferase, family 2
N1236_03330	COG0463	Glycosyl transferase, family 2
N1236_03340	COG1216	Glycosyl transferase, family 2
N1236_03345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N1236_03350	COG0436	Aminotransferase
N1236_03355	COG1316	TRANSCRIPTIONal
N1236_03370	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N1236_03375	COG0720	synthase
N1236_03380	COG0602	queuosine metabolic process
N1236_03385	COG1573	uracil-dna glycosylase
N1236_03390	COG1573	uracil-dna glycosylase
N1236_03420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N1236_03430	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
N1236_03435	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N1236_03450	COG1482	cell wall glycoprotein biosynthetic process
N1236_03460	COG2703	oxygen carrier activity
N1236_03465	COG1773	rubredoxin
N1236_03465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N1236_03480	COG1361	Conserved repeat domain
N1236_03490	COG0318	PFAM AMP-dependent synthetase and ligase
N1236_03500	COG1051	belongs to the nudix hydrolase family
N1236_03500	COG1056	cytidyltransferase-related domain
N1236_03515	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N1236_03530	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
N1236_03535	COG2267	carboxylic ester hydrolase activity
N1236_03550	COG1404	Belongs to the peptidase S8 family
N1236_03565	COG2755	lipolytic protein G-D-S-L family
N1236_03565	COG3401	FG-GAP repeat protein
N1236_03580	COG3708	Transcriptional regulator
N1236_03580	COG2207	Transcriptional regulator
N1236_03595	COG1132	(ABC) transporter
N1236_03600	COG1132	(ABC) transporter
N1236_03605	COG2195	Cleaves the N-terminal amino acid of tripeptides
N1236_03620	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
N1236_03640	COG0840	transmembrane signaling receptor activity
N1236_03645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N1236_03650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N1236_03655	COG1802	Transcriptional regulator
N1236_03660	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
N1236_03660	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N1236_03665	COG1187	pseudouridine synthase activity
N1236_03690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N1236_03695	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N1236_03700	COG1597	lipid kinase activity
N1236_03710	COG1136	(ABC) transporter
N1236_03725	COG0577	efflux transmembrane transporter activity
N1236_03725	COG1136	(ABC) transporter
N1236_03745	COG2323	membrane
N1236_03765	COG1686	Belongs to the peptidase S11 family
N1236_03775	COG0569	domain protein
N1236_03810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N1236_03855	COG0628	permease
N1236_03860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N1236_03925	COG3328	transposase activity
N1236_03985	COG3328	transposase activity
N1236_03990	COG3328	transposase activity
N1236_04045	COG3328	transposase activity
N1236_04075	COG2226	methyltransferase
N1236_04095	COG0107	imidazoleglycerol-phosphate synthase activity
N1236_04125	COG3328	transposase activity
N1236_04130	COG0723	plastoquinol--plastocyanin reductase activity
N1236_04130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N1236_04150	COG1126	abc transporter atp-binding protein
N1236_04205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N1236_04245	COG1595	DNA-templated transcription, initiation
N1236_04265	COG1028	Short-chain dehydrogenase reductase Sdr
N1236_04300	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
N1236_04305	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
N1236_04315	COG0628	permease
N1236_04325	COG1714	RDD family
N1236_04330	COG0616	signal peptide processing
N1236_04335	COG1971	Probably functions as a manganese efflux pump
N1236_04350	COG1131	(ABC) transporter
N1236_04365	COG0133	tryptophan synthase activity
N1236_04370	COG0159	tryptophan synthase activity
N1236_04375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N1236_04380	COG5002	protein histidine kinase activity
N1236_04385	COG0745	RESPONSE REGULATOR receiver
N1236_04400	COG5337	Spore coat protein CotH
N1236_04405	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
N1236_04415	COG1321	iron dependent repressor
N1236_04435	COG4447	cellulose binding
N1236_04440	COG1442	glycosyl transferase family 8
N1236_04450	COG0745	RESPONSE REGULATOR receiver
N1236_04455	COG5002	protein histidine kinase activity
N1236_04460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N1236_04465	COG2267	carboxylic ester hydrolase activity
N1236_04470	COG0617	tRNA 3'-terminal CCA addition
N1236_04475	COG4496	protein, YerC YecD
N1236_04490	COG0653	protein targeting
N1236_04495	COG0285	dihydrofolate synthase activity
N1236_04505	COG1752	Esterase of the alpha-beta hydrolase superfamily
N1236_04515	COG2201	protein-glutamate methylesterase activity
N1236_04520	COG0673	inositol 2-dehydrogenase activity
N1236_04525	COG2199	diguanylate cyclase activity
N1236_04525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N1236_04530	COG4492	Belongs to the UPF0735 family
N1236_04535	COG0460	homoserine dehydrogenase
N1236_04540	COG0527	aspartate kinase activity
N1236_04580	COG0537	adenosine 5'-monophosphoramidase activity
N1236_04585	COG1361	Conserved repeat domain
N1236_04590	COG4464	protein tyrosine phosphatase activity
N1236_04610	COG0489	protein tyrosine kinase activity
N1236_04620	COG0438	transferase activity, transferring glycosyl groups
N1236_04630	COG1442	glycosyl transferase family 8
N1236_04630	COG1216	Glycosyl transferase, family 2
N1236_04635	COG1216	Glycosyl transferase, family 2
N1236_04650	COG1216	Glycosyl transferase, family 2
N1236_04670	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N1236_04680	COG0629	single-stranded DNA binding
N1236_04685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N1236_04690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N1236_04700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N1236_04700	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
N1236_04705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N1236_04710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N1236_04715	COG1490	D-aminoacyl-tRNA deacylase activity
N1236_04720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N1236_04725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N1236_04775	COG0124	histidyl-tRNA synthetase
N1236_04780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N1236_04810	COG0481	GTPase activity
N1236_04815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N1236_04820	COG1420	regulation of RNA biosynthetic process
N1236_04825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N1236_04830	COG0443	Heat shock 70 kDa protein
N1236_04835	COG0484	heat shock protein binding
N1236_04840	COG2264	protein methyltransferase activity
N1236_04845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N1236_04850	COG2201	protein-glutamate methylesterase activity
N1236_04855	COG1561	YicC-like family, N-terminal region
N1236_04860	COG2052	Domain of unknown function (DUF370)
N1236_04865	COG0194	GDP metabolic process
N1236_04870	COG1758	RNA polymerase activity
N1236_04875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N1236_04880	COG0423	glycine-tRNA ligase activity
N1236_04885	COG3290	protein histidine kinase activity
N1236_04900	COG0535	radical SAM domain protein
N1236_04905	COG0574	Belongs to the PEP-utilizing enzyme family
N1236_04905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N1236_04910	COG3693	PFAM glycoside hydrolase, family 10
N1236_04925	COG0662	Cupin 2, conserved barrel domain protein
N1236_04930	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N1236_04940	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N1236_04945	COG1323	Belongs to the UPF0348 family
N1236_04965	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N1236_04975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N1236_04990	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
N1236_05010	COG0745	RESPONSE REGULATOR receiver
N1236_05015	COG5002	protein histidine kinase activity
N1236_05015	COG3850	Histidine kinase
N1236_05020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N1236_05025	COG2199	diguanylate cyclase activity
N1236_05025	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N1236_05030	COG0297	glycogen (starch) synthase activity
N1236_05035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N1236_05050	COG2261	transglycosylase associated protein
N1236_05055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N1236_05060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N1236_05065	COG0742	ribosomal rna small subunit methyltransferase
N1236_05070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N1236_05080	COG3314	Sporulation integral membrane protein YlbJ
N1236_05085	COG2755	lipolytic protein G-D-S-L family
N1236_05090	COG1191	sigma factor activity
N1236_05095	COG3507	Belongs to the glycosyl hydrolase 43 family
N1236_05110	COG4585	Histidine kinase
N1236_05115	COG2197	response regulator
N1236_05120	COG0840	transmembrane signaling receptor activity
N1236_05125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N1236_05145	COG0205	6-phosphofructokinase activity
N1236_05170	COG1472	Belongs to the glycosyl hydrolase 3 family
N1236_05195	COG2252	PERMEase
N1236_05200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N1236_05205	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N1236_05210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N1236_05215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N1236_05220	COG0138	bifunctional purine biosynthesis protein purh
N1236_05225	COG0151	Belongs to the GarS family
N1236_05230	COG1216	Glycosyl transferase, family 2
N1236_05240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N1236_05245	COG1713	HD superfamily hydrolase involved in NAD metabolism
N1236_05255	COG0799	negative regulation of ribosome biogenesis
N1236_05260	COG0495	leucyl-tRNA aminoacylation
N1236_05270	COG0840	transmembrane signaling receptor activity
N1236_05280	COG1022	Amp-dependent synthetase and ligase
N1236_05285	COG1686	Belongs to the peptidase S11 family
N1236_05290	COG1596	polysaccharide export
N1236_05290	COG1555	photosystem II stabilization
N1236_05300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N1236_05310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N1236_05315	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N1236_05320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N1236_05325	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N1236_05330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N1236_05335	COG3459	Glycosyltransferase 36 associated
N1236_05350	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N1236_05355	COG0542	response to heat
N1236_05360	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N1236_05365	COG0730	response to heat
N1236_05385	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
N1236_05415	COG2766	serine protein kinase
N1236_05420	COG2718	Belongs to the UPF0229 family
N1236_05425	COG2719	SpoVR family
N1236_05440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N1236_05445	COG0402	S-adenosylhomocysteine deaminase activity
N1236_05480	COG0546	phosphoglycolate phosphatase activity
N1236_05490	COG4555	ABC transporter
N1236_05505	COG0657	acetylesterase activity
N1236_05520	COG0714	Associated with various cellular activities
N1236_05530	COG1305	Transglutaminase-like
N1236_05550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N1236_05555	COG1406	Chemotaxis phosphatase CheX
N1236_05590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N1236_05600	COG2078	PFAM AMMECR1 domain protein
N1236_05600	COG3885	ferrous iron binding
N1236_05610	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
N1236_05620	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
N1236_05625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N1236_05630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N1236_05665	COG1408	metallophosphoesterase
N1236_05710	COG3328	transposase activity
N1236_05770	COG0514	ATP-dependent DNA helicase (RecQ)
N1236_05785	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N1236_05795	COG3328	transposase activity
N1236_05805	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N1236_05810	COG1397	ADP-ribosylglycohydrolase
N1236_05830	COG3328	transposase activity
N1236_05860	COG1196	nuclear chromosome segregation
N1236_05865	COG2801	Transposase and inactivated derivatives
N1236_05905	COG3328	transposase activity
N1236_05930	COG3328	transposase activity
N1236_05960	COG0640	Transcriptional regulator
N1236_05965	COG0798	PFAM Bile acid sodium symporter
N1236_05975	COG0701	Predicted permease
N1236_05990	COG3328	transposase activity
N1236_06005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N1236_06015	COG1459	type II secretion system
N1236_06055	COG0740	serine-type endopeptidase activity
N1236_06065	COG1674	ftsk spoiiie
N1236_06075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N1236_06085	COG1418	mRNA catabolic process
N1236_06090	COG1692	metallophosphoesterase
N1236_06095	COG2359	stage V sporulation protein S
N1236_06115	COG0438	transferase activity, transferring glycosyl groups
N1236_06125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N1236_06145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N1236_06185	COG1702	phosphate starvation-inducible protein PhoH
N1236_06190	COG1480	7TM receptor with intracellular HD hydrolase
N1236_06195	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N1236_06200	COG0295	cytidine deaminase activity
N1236_06205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N1236_06215	COG1381	Involved in DNA repair and RecF pathway recombination
N1236_06225	COG1104	cysteine desulfurase activity
N1236_06230	COG0301	tRNA thio-modification
N1236_06235	COG2720	vancomycin resistance protein
N1236_06250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N1236_06255	COG1983	PspC domain protein
N1236_06260	COG1305	Transglutaminase-like
N1236_06270	COG0714	Associated with various cellular activities
N1236_06275	COG0039	L-malate dehydrogenase activity
N1236_06280	COG1058	Belongs to the CinA family
N1236_06280	COG1546	Belongs to the CinA family
N1236_06285	COG0728	peptidoglycan biosynthetic process
N1236_06290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N1236_06300	COG0705	Rhomboid family
N1236_06300	COG0457	Tetratricopeptide repeat
N1236_06340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N1236_06365	COG1466	dna polymerase III delta subunit
N1236_06370	COG0268	Binds directly to 16S ribosomal RNA
N1236_06390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N1236_06400	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N1236_06405	COG0154	amidase activity
N1236_06410	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N1236_06420	COG0280	phosphate acetyltransferase
N1236_06425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N1236_06435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N1236_06445	COG1160	GTP binding
N1236_06455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N1236_06460	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
N1236_06470	COG1175	transmembrane transport
N1236_06475	COG0395	ABC-type sugar transport system, permease component
N1236_06485	COG0860	N-Acetylmuramoyl-L-alanine amidase
N1236_06485	COG2247	cell wall binding repeat
N1236_06500	COG1193	negative regulation of DNA recombination
N1236_06505	COG0628	permease
N1236_06515	COG0768	penicillin binding
N1236_06520	COG0826	peptidase U32
N1236_06525	COG4122	O-methyltransferase activity
N1236_06530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N1236_06535	COG1217	gtp-binding protein TYPA
N1236_06540	COG0052	Belongs to the universal ribosomal protein uS2 family
N1236_06545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N1236_06550	COG0528	UMP kinase activity
N1236_06555	COG0233	cytoplasmic translational termination
N1236_06565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N1236_06570	COG0575	Belongs to the CDS family
N1236_06575	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N1236_06585	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N1236_06595	COG0779	Required for maturation of 30S ribosomal subunits
N1236_06600	COG0195	Participates in both transcription termination and antitermination
N1236_06605	COG2740	Nucleic-acid-binding protein implicated in transcription termination
N1236_06615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N1236_06620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N1236_06625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N1236_06630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N1236_06635	COG0196	riboflavin kinase activity
N1236_06645	COG0612	Peptidase, M16
N1236_06650	COG0612	Peptidase, M16
N1236_06655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N1236_06665	COG0772	Belongs to the SEDS family
N1236_06670	COG2001	Belongs to the MraZ family
N1236_06675	COG0275	rRNA processing
N1236_06685	COG0768	penicillin binding
N1236_06690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N1236_06695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N1236_06700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N1236_06705	COG0772	Belongs to the SEDS family
N1236_06710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N1236_06715	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N1236_06730	COG3328	transposase activity
N1236_06755	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
N1236_06765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N1236_06770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N1236_06775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N1236_06780	COG2247	cell wall binding repeat
N1236_06780	COG2385	sporulation resulting in formation of a cellular spore
N1236_06785	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N1236_06790	COG0343	queuine tRNA-ribosyltransferase activity
N1236_06795	COG1862	Preprotein translocase
N1236_06810	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N1236_06815	COG0540	Belongs to the ATCase OTCase family
N1236_06820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N1236_06835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N1236_06840	COG0543	2 iron, 2 sulfur cluster binding
N1236_06845	COG0167	dihydroorotate dehydrogenase activity
N1236_06850	COG0588	phosphoglycerate mutase activity
N1236_06870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N1236_06875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N1236_06900	COG2030	dehydratase
N1236_06905	COG0416	fatty acid biosynthetic process
N1236_06910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N1236_06915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N1236_06920	COG1028	Short-chain dehydrogenase reductase Sdr
N1236_06925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N1236_06930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N1236_06935	COG0571	ribonuclease III activity
N1236_06945	COG2359	stage V sporulation protein S
N1236_06960	COG0552	protein localization to endoplasmic reticulum
N1236_06980	COG1748	Saccharopine dehydrogenase
N1236_07000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N1236_07025	COG1496	oxidoreductase activity
N1236_07035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N1236_07040	COG0564	pseudouridine synthase activity
N1236_07055	COG1418	mRNA catabolic process
N1236_07060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N1236_07065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N1236_07070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N1236_07075	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N1236_07080	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
N1236_07095	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N1236_07100	COG0358	DNA primase activity
N1236_07105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N1236_07130	COG2384	SAM-dependent methyltransferase
N1236_07135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N1236_07145	COG3437	response regulator, receiver
N1236_07150	COG1595	DNA-templated transcription, initiation
N1236_07170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N1236_07170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N1236_07175	COG0237	dephospho-CoA kinase activity
N1236_07190	COG0697	spore germination
N1236_07195	COG3706	GGDEF domain
N1236_07200	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
N1236_07205	COG0835	chemotaxis
N1236_07210	COG0012	GTP binding
N1236_07225	COG0512	Glutamine amidotransferase of anthranilate synthase
N1236_07225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N1236_07230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N1236_07235	COG0134	indole-3-glycerol-phosphate synthase activity
N1236_07240	COG0135	phosphoribosylanthranilate isomerase activity
N1236_07290	COG1316	TRANSCRIPTIONal
N1236_07295	COG1592	Rubrerythrin
N1236_07305	COG4864	UPF0365 protein
N1236_07310	COG1030	water channel activity
N1236_07315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N1236_07320	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
N1236_07325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N1236_07330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N1236_07335	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
N1236_07345	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N1236_07350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N1236_07355	COG0006	proline dipeptidase activity
N1236_07360	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N1236_07375	COG3854	ATPases associated with a variety of cellular activities
N1236_07415	COG1302	Protein conserved in bacteria
N1236_07430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N1236_07435	COG1570	exodeoxyribonuclease VII activity
N1236_07440	COG1722	exodeoxyribonuclease VII activity
N1236_07450	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
N1236_07460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N1236_07465	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
N1236_07475	COG3291	Pkd domain containing protein
N1236_07500	COG1131	(ABC) transporter
N1236_07515	COG3706	GGDEF domain
N1236_07520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N1236_07525	COG1438	arginine binding
N1236_07530	COG0497	DNA recombination
N1236_07535	COG0750	zinc metalloprotease
N1236_07540	COG0745	RESPONSE REGULATOR receiver
N1236_07545	COG2201	protein-glutamate methylesterase activity
N1236_07550	COG0643	Histidine kinase
N1236_07550	COG2198	Histidine kinase
N1236_07555	COG0835	chemotaxis
N1236_07565	COG2201	protein-glutamate methylesterase activity
N1236_07575	COG0745	RESPONSE REGULATOR receiver
N1236_07585	COG0564	pseudouridine synthase activity
N1236_07600	COG3328	transposase activity
N1236_07605	COG5002	protein histidine kinase activity
N1236_07610	COG0745	RESPONSE REGULATOR receiver
N1236_07620	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
N1236_07620	COG2755	lipolytic protein G-D-S-L family
N1236_07625	COG0366	Alpha amylase catalytic
N1236_07630	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
N1236_07640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N1236_07645	COG1799	cell septum assembly
N1236_07655	COG2302	S4 RNA-binding domain
N1236_07660	COG3599	regulation of cell shape
N1236_07670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N1236_07685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N1236_07700	COG0840	transmembrane signaling receptor activity
N1236_07710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N1236_07715	COG2340	Cysteine-rich secretory protein family
N1236_07725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N1236_07730	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N1236_07735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N1236_07740	COG1923	regulation of RNA biosynthetic process
N1236_07745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N1236_07755	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
N1236_07760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N1236_07765	COG0228	four-way junction DNA binding
N1236_07770	COG1837	Belongs to the UPF0109 family
N1236_07775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N1236_07780	COG0336	Belongs to the RNA methyltransferase TrmD family
N1236_07785	COG0335	large ribosomal subunit rRNA binding
N1236_07805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N1236_07820	COG0792	nuclease activity
N1236_07825	COG2003	Belongs to the UPF0758 family
N1236_07860	COG3842	ATPase activity
N1236_07865	COG1176	ABC-type spermidine putrescine transport system, permease component I
N1236_07885	COG4733	cellulase activity
N1236_07890	COG3409	Peptidoglycan-binding domain 1 protein
N1236_07890	COG0793	Belongs to the peptidase S41A family
N1236_07895	COG0534	Mate efflux family protein
N1236_07905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N1236_07910	COG2188	Transcriptional regulator
N1236_07935	COG1361	Conserved repeat domain
N1236_07935	COG3266	domain, Protein
N1236_07935	COG2911	Protein conserved in bacteria
N1236_07940	COG1361	Conserved repeat domain
N1236_07940	COG2911	Protein conserved in bacteria
N1236_07940	COG3266	domain, Protein
N1236_07955	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N1236_07970	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
N1236_07975	COG4974	Belongs to the 'phage' integrase family
N1236_07985	COG1362	aminopeptidase activity
N1236_07990	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N1236_07990	COG2199	diguanylate cyclase activity
N1236_07995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
N1236_08000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N1236_08005	COG0482	sulfurtransferase activity
N1236_08010	COG0822	iron-sulfur transferase activity
N1236_08020	COG1959	2 iron, 2 sulfur cluster binding
N1236_08035	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N1236_08040	COG0105	UTP biosynthetic process
N1236_08045	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
N1236_08050	COG0539	negative regulation of cytoplasmic translation
N1236_08050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N1236_08055	COG0204	Acyl-transferase
N1236_08080	COG2081	HI0933 family
N1236_08085	COG0406	alpha-ribazole phosphatase activity
N1236_08090	COG1737	Transcriptional regulator
N1236_08120	COG0511	ligase activity, forming carbon-carbon bonds
N1236_08130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N1236_08140	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
N1236_08145	COG0010	Belongs to the arginase family
N1236_08150	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N1236_08155	COG1187	pseudouridine synthase activity
N1236_08160	COG3874	Sporulation protein YtfJ
N1236_08175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N1236_08180	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N1236_08185	COG0180	Tryptophanyl-tRNA synthetase
N1236_08190	COG1994	Peptidase M50
N1236_08195	COG0617	tRNA 3'-terminal CCA addition
N1236_08195	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N1236_08195	COG3620	sequence-specific DNA binding
N1236_08210	COG0516	GMP reductase activity
N1236_08210	COG0517	IMP dehydrogenase activity
N1236_08220	COG1686	Belongs to the peptidase S11 family
N1236_08230	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N1236_08235	COG4974	Belongs to the 'phage' integrase family
N1236_08240	COG1300	Membrane
N1236_08250	COG0328	RNA-DNA hybrid ribonuclease activity
N1236_08255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N1236_08290	COG0697	spore germination
N1236_08295	COG0330	HflC and HflK could
N1236_08305	COG3583	domain protein
N1236_08305	COG3584	3D domain protein
N1236_08320	COG2273	Hydrolase Family 16
N1236_08325	COG4447	cellulose binding
N1236_08355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N1236_08370	COG1942	4-Oxalocrotonate Tautomerase
N1236_08400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N1236_08455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
N1236_08470	COG3949	Membrane
N1236_08490	COG2273	Hydrolase Family 16
N1236_08495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N1236_08515	COG0631	protein serine/threonine phosphatase activity
N1236_08520	COG2815	serine threonine protein kinase
N1236_08520	COG0515	serine threonine protein kinase
N1236_08570	COG5297	Belongs to the glycosyl hydrolase family 6
N1236_08580	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N1236_08585	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
N1236_08590	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
N1236_08595	COG1321	iron dependent repressor
N1236_08605	COG1918	ferrous iron import across plasma membrane
N1236_08605	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
N1236_08615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N1236_08645	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N1236_08650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N1236_08675	COG0791	NLP P60 protein
N1236_08685	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N1236_08690	COG0352	thiamine-phosphate diphosphorylase activity
N1236_08700	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N1236_08705	COG2022	thiamine diphosphate biosynthetic process
N1236_08710	COG2022	thiamine diphosphate biosynthetic process
N1236_08710	COG2104	thiamine diphosphate biosynthetic process
N1236_08715	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N1236_08735	COG2226	methyltransferase
N1236_08765	COG2204	response regulator
N1236_08775	COG1293	RNA-binding protein homologous to eukaryotic snRNP
N1236_08780	COG0436	Aminotransferase
N1236_08785	COG0778	Nitroreductase
N1236_08800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N1236_08805	COG1162	GTPase activity
N1236_08810	COG0515	serine threonine protein kinase
N1236_08810	COG2815	serine threonine protein kinase
N1236_08815	COG0631	protein serine/threonine phosphatase activity
N1236_08820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N1236_08825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N1236_08825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N1236_08830	COG2738	Putative neutral zinc metallopeptidase
N1236_08840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N1236_08845	COG0242	peptide deformylase activity
N1236_08850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N1236_08875	COG1477	protein flavinylation
N1236_08880	COG1252	NADH dehydrogenase
N1236_08900	COG0367	asparagine synthase
N1236_08905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N1236_08910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N1236_08915	COG0583	DNA-binding transcription factor activity
N1236_08925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N1236_08930	COG0326	Molecular chaperone. Has ATPase activity
N1236_08935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N1236_08940	COG1121	(ABC) transporter
N1236_08945	COG0803	Belongs to the bacterial solute-binding protein 9 family
N1236_08950	COG0735	belongs to the Fur family
N1236_08960	COG0631	protein serine/threonine phosphatase activity
N1236_08965	COG5297	Belongs to the glycosyl hydrolase family 6
N1236_08980	COG1136	(ABC) transporter
N1236_08980	COG0577	efflux transmembrane transporter activity
N1236_08985	COG1136	(ABC) transporter
N1236_08990	COG3850	Histidine kinase
N1236_08990	COG5002	protein histidine kinase activity
N1236_08995	COG0745	RESPONSE REGULATOR receiver
N1236_09000	COG4447	cellulose binding
N1236_09000	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
N1236_09010	COG2274	protein secretion by the type I secretion system
N1236_09055	COG5002	protein histidine kinase activity
N1236_09075	COG2176	DNA-directed DNA polymerase activity
N1236_09080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N1236_09090	COG2843	Capsule synthesis protein
N1236_09125	COG1191	sigma factor activity
N1236_09135	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
N1236_09140	COG1776	CheC inhibitor of MCP methylation
N1236_09145	COG0835	chemotaxis
N1236_09150	COG0643	Histidine kinase
N1236_09150	COG2198	Histidine kinase
N1236_09155	COG2201	protein-glutamate methylesterase activity
N1236_09170	COG1419	protein localization to endoplasmic reticulum
N1236_09175	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N1236_09180	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N1236_09185	COG1684	flagellar biosynthetic protein fliR
N1236_09190	COG1987	bacterial-type flagellum assembly
N1236_09195	COG1338	Plays a role in the flagellum-specific transport system
N1236_09205	COG2201	protein-glutamate methylesterase activity
N1236_09210	COG1776	CheC inhibitor of MCP methylation
N1236_09210	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N1236_09215	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N1236_09225	COG1582	Flagellar protein (FlbD)
N1236_09240	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
N1236_09260	COG1157	protein secretion by the type III secretion system
N1236_09265	COG1317	bacterial-type flagellum organization
N1236_09270	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N1236_09280	COG1677	Flagellar hook-basal body complex protein FliE
N1236_09285	COG1558	bacterial-type flagellum-dependent cell motility
N1236_09290	COG1815	bacterial-type flagellum-dependent cell motility
N1236_09295	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
N1236_09300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N1236_09305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N1236_09305	COG0758	DNA mediated transformation
N1236_09310	COG0708	Exodeoxyribonuclease III
N1236_09315	COG3304	Inner membrane component domain
N1236_09325	COG0606	chelatase, subunit chli
N1236_09350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N1236_09355	COG1873	PFAM PRC-barrel domain
N1236_09360	COG1191	sigma factor activity
N1236_09365	COG1191	sigma factor activity
N1236_09375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N1236_09380	COG0849	cell division
N1236_09385	COG3856	small basic protein
N1236_09390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N1236_09395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N1236_09400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N1236_09405	COG3442	glutamine amidotransferase
N1236_09410	COG4447	cellulose binding
N1236_09445	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
N1236_09485	COG1012	belongs to the aldehyde dehydrogenase family
N1236_09485	COG1454	alcohol dehydrogenase
N1236_09490	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
N1236_09495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N1236_09505	COG0612	Peptidase, M16
N1236_09510	COG1185	polyribonucleotide nucleotidyltransferase activity
N1236_09515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N1236_09530	COG3546	catalase activity
N1236_09540	COG2273	Hydrolase Family 16
N1236_09540	COG5297	Belongs to the glycosyl hydrolase family 6
N1236_09555	COG2848	UPF0210 protein
N1236_09560	COG3830	Belongs to the UPF0237 family
N1236_09585	COG4447	cellulose binding
N1236_09590	COG1191	sigma factor activity
N1236_09615	COG0393	Putative heavy-metal-binding
N1236_09620	COG1132	(ABC) transporter
N1236_09625	COG1132	(ABC) transporter
N1236_09630	COG1869	D-ribose catabolic process
N1236_09645	COG1172	Belongs to the binding-protein-dependent transport system permease family
N1236_09650	COG1129	ABC transporter
N1236_09655	COG1940	carbohydrate kinase activity
N1236_09660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N1236_09665	COG1063	alcohol dehydrogenase
N1236_09675	COG0577	efflux transmembrane transporter activity
N1236_09675	COG1136	(ABC) transporter
N1236_09685	COG3328	transposase activity
N1236_09730	COG0519	Catalyzes the synthesis of GMP from XMP
N1236_09735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N1236_09755	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
N1236_09760	COG1691	(AIR) carboxylase
N1236_09765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N1236_09780	COG3620	sequence-specific DNA binding
N1236_09790	COG0436	Aminotransferase
N1236_09795	COG1522	sequence-specific DNA binding
N1236_09805	COG3118	belongs to the thioredoxin family
N1236_09825	COG3328	transposase activity
N1236_09830	COG1379	DNA repair
N1236_09835	COG1924	4 iron, 4 sulfur cluster binding
N1236_09850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N1236_09855	COG0681	Belongs to the peptidase S26 family
N1236_09860	COG0191	fructose-bisphosphate aldolase activity
N1236_09865	COG0205	6-phosphofructokinase activity
N1236_09875	COG0039	L-malate dehydrogenase activity
N1236_09880	COG0281	malic enzyme
N1236_09905	COG2205	protein histidine kinase activity
N1236_09905	COG0784	Response regulator, receiver
N1236_09940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N1236_09965	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N1236_09970	COG2911	Protein conserved in bacteria
N1236_09970	COG1361	Conserved repeat domain
N1236_09970	COG3266	domain, Protein
N1236_10000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N1236_10000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N1236_10005	COG0525	valine-tRNA ligase activity
N1236_10015	COG1472	Belongs to the glycosyl hydrolase 3 family
N1236_10035	COG1376	ErfK ybiS ycfS ynhG family protein
N1236_10045	COG2133	pyrroloquinoline quinone binding
N1236_10045	COG5183	chlorophyll binding
N1236_10050	COG1191	sigma factor activity
N1236_10065	COG0542	response to heat
N1236_10080	COG3583	domain protein
N1236_10080	COG3584	3D domain protein
N1236_10085	COG0556	nucleotide-excision repair
N1236_10100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N1236_10105	COG0187	DNA topoisomerase II activity
N1236_10125	COG2966	Psort location CytoplasmicMembrane, score
N1236_10130	COG2340	Cysteine-rich secretory protein family
N1236_10135	COG0534	Mate efflux family protein
N1236_10140	COG0840	transmembrane signaling receptor activity
N1236_10185	COG1331	Highly conserved protein containing a thioredoxin domain
N1236_10190	COG0460	homoserine dehydrogenase
N1236_10195	COG1199	ATP-dependent helicase activity
N1236_10200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N1236_10205	COG2205	protein histidine kinase activity
N1236_10205	COG0784	Response regulator, receiver
N1236_10210	COG2205	protein histidine kinase activity
N1236_10215	COG0538	isocitrate dehydrogenase activity
N1236_10225	COG0667	Aldo Keto reductase
N1236_10230	COG0297	glycogen (starch) synthase activity
N1236_10245	COG0564	pseudouridine synthase activity
N1236_10250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N1236_10250	COG0116	Belongs to the methyltransferase superfamily
N1236_10255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N1236_10260	COG3459	Glycosyltransferase 36 associated
N1236_10265	COG4447	cellulose binding
N1236_10265	COG4733	cellulase activity
N1236_10270	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N1236_10270	COG2199	diguanylate cyclase activity
N1236_10275	COG1686	Belongs to the peptidase S11 family
N1236_10280	COG4733	cellulase activity
N1236_10280	COG4447	cellulose binding
N1236_10290	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
N1236_10295	COG1191	sigma factor activity
N1236_10300	COG4447	cellulose binding
N1236_10305	COG0840	transmembrane signaling receptor activity
N1236_10310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N1236_10325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N1236_10335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N1236_10345	COG4447	cellulose binding
N1236_10355	COG1609	Transcriptional regulator
N1236_10370	COG0714	Associated with various cellular activities
N1236_10385	COG1690	Belongs to the RtcB family
N1236_10400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N1236_10405	COG3401	FG-GAP repeat protein
N1236_10420	COG2217	Heavy metal translocating P-type atpase
N1236_10425	COG3409	Peptidoglycan-binding domain 1 protein
N1236_10425	COG3773	Cell wall hydrolase
N1236_10445	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
N1236_10450	COG0745	RESPONSE REGULATOR receiver
N1236_10455	COG0667	Aldo Keto reductase
N1236_10465	COG0318	PFAM AMP-dependent synthetase and ligase
N1236_10470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N1236_10480	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N1236_10520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N1236_10565	COG1408	metallophosphoesterase
N1236_10570	COG0166	Belongs to the GPI family
N1236_10580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N1236_10580	COG0072	phenylalanine-tRNA ligase activity
N1236_10585	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N1236_10595	COG2723	6-phospho-beta-galactosidase activity
N1236_10605	COG2273	Hydrolase Family 16
N1236_10610	COG1609	Transcriptional regulator
N1236_10615	COG1215	transferase activity, transferring glycosyl groups
N1236_10620	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
N1236_10620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N1236_10660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N1236_10665	COG0493	'glutamate synthase
N1236_10665	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
N1236_10670	COG0069	glutamate synthase activity
N1236_10675	COG0067	glutamate synthase
N1236_10695	COG0475	glutathione-regulated potassium exporter activity
N1236_10710	COG2273	Hydrolase Family 16
N1236_10715	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
N1236_10720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N1236_10725	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N1236_10730	COG5401	PFAM Sporulation and spore germination
N1236_10735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N1236_10740	COG0860	N-Acetylmuramoyl-L-alanine amidase
N1236_10750	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N1236_10755	COG2255	four-way junction helicase activity
N1236_10760	COG0632	four-way junction helicase activity
N1236_10765	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N1236_10770	COG0137	argininosuccinate synthase activity
N1236_10775	COG0165	Argininosuccinate lyase
N1236_10795	COG1368	sulfuric ester hydrolase activity
N1236_10800	COG0493	'glutamate synthase
N1236_10800	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
N1236_10830	COG2201	protein-glutamate methylesterase activity
N1236_10835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N1236_10845	COG1534	Rna-binding protein
N1236_10855	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N1236_10860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N1236_10870	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N1236_10890	COG1470	cell adhesion involved in biofilm formation
N1236_10895	COG3906	Belongs to the UPF0473 family
N1236_10900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N1236_10905	COG0667	Aldo Keto reductase
N1236_10910	COG4472	Bacterial protein of unknown function (DUF965)
N1236_10915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N1236_10925	COG1683	Conserved Protein
N1236_10930	COG0557	exoribonuclease II activity
N1236_10945	COG0148	phosphopyruvate hydratase activity
N1236_10950	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N1236_10950	COG2199	diguanylate cyclase activity
N1236_10955	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N1236_10960	COG0149	triose-phosphate isomerase activity
N1236_10965	COG0126	phosphoglycerate kinase activity
N1236_10990	COG0318	PFAM AMP-dependent synthetase and ligase
N1236_10995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N1236_11000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N1236_11005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N1236_11060	COG1366	Belongs to the anti-sigma-factor antagonist family
N1236_11065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N1236_11070	COG1481	regulation of sporulation
N1236_11080	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N1236_11085	COG1660	Displays ATPase and GTPase activities
N1236_11090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N1236_11095	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
N1236_11100	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
N1236_11130	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N1236_11150	COG0432	Pfam Uncharacterised protein family UPF0047
N1236_11155	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N1236_11160	COG1979	alcohol dehydrogenase
N1236_11170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N1236_11180	COG0739	heme binding
N1236_11190	COG1803	Methylglyoxal synthase
N1236_11195	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
N1236_11200	COG2894	cell division
N1236_11205	COG0850	regulation of cytokinetic process
N1236_11210	COG0768	penicillin binding
N1236_11225	COG1077	Cell shape determining protein MreB Mrl
N1236_11230	COG0424	maF-like protein
N1236_11255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N1236_11260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N1236_11265	COG0835	chemotaxis
N1236_11310	COG4447	cellulose binding
N1236_11310	COG5297	Belongs to the glycosyl hydrolase family 6
N1236_11315	COG0017	Asparaginyl-tRNA synthetase
N1236_11320	COG2502	aspartate--ammonia ligase
N1236_11325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N1236_11345	COG1283	sodium-dependent phosphate transmembrane transporter activity
N1236_11355	COG1368	sulfuric ester hydrolase activity
N1236_11360	COG1268	BioY protein
N1236_11365	COG0653	protein targeting
N1236_11370	COG4447	cellulose binding
N1236_11375	COG1191	sigma factor activity
N1236_11395	COG1649	PFAM Uncharacterised BCR, COG1649
N1236_11445	COG2382	esterase
N1236_11445	COG3507	Belongs to the glycosyl hydrolase 43 family
N1236_11445	COG3693	PFAM glycoside hydrolase, family 10
N1236_11450	COG4733	cellulase activity
N1236_11450	COG4447	cellulose binding
N1236_11455	COG1160	GTP binding
N1236_11465	COG4733	cellulase activity
N1236_11465	COG4447	cellulose binding
N1236_11470	COG0840	transmembrane signaling receptor activity
N1236_11475	COG0835	chemotaxis
N1236_11485	COG1151	hydroxylamine reductase activity
N1236_11505	COG4124	Belongs to the glycosyl hydrolase 26 family
N1236_11545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N1236_11550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N1236_11565	COG4106	trans-aconitate 2-methyltransferase activity
N1236_11570	COG2267	carboxylic ester hydrolase activity
N1236_11575	COG0156	8-amino-7-oxononanoate synthase activity
N1236_11580	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N1236_11585	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N1236_11610	COG3507	Belongs to the glycosyl hydrolase 43 family
N1236_11655	COG3328	transposase activity
N1236_11675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N1236_11695	COG1595	DNA-templated transcription, initiation
N1236_11705	COG4124	Belongs to the glycosyl hydrolase 26 family
N1236_11705	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
N1236_11720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N1236_11730	COG0717	Belongs to the dCTP deaminase family
N1236_11745	COG2409	Drug exporters of the RND superfamily
N1236_11755	COG0561	phosphatase activity
N1236_11775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N1236_11775	COG0426	domain, Protein
N1236_11780	COG0494	nUDIX hydrolase
N1236_11790	COG0840	transmembrane signaling receptor activity
N1236_11810	COG1695	Transcriptional regulator
N1236_11830	COG0840	transmembrane signaling receptor activity
N1236_11835	COG0004	ammonium transporteR
N1236_11840	COG1132	(ABC) transporter
N1236_11845	COG1132	(ABC) transporter
N1236_11865	COG2911	Protein conserved in bacteria
N1236_11865	COG1361	Conserved repeat domain
N1236_11865	COG3266	domain, Protein
N1236_11880	COG1393	Belongs to the ArsC family
N1236_11965	COG0577	efflux transmembrane transporter activity
N1236_11970	COG1136	(ABC) transporter
N1236_11975	COG2205	protein histidine kinase activity
N1236_11980	COG0745	RESPONSE REGULATOR receiver
N1236_12015	COG1131	(ABC) transporter
N1236_12025	COG3620	sequence-specific DNA binding
N1236_12035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N1236_12040	COG0154	amidase activity
N1236_12050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N1236_12080	COG1024	Enoyl-CoA hydratase
N1236_12085	COG4106	trans-aconitate 2-methyltransferase activity
N1236_12095	COG2140	Oxalate decarboxylase
N1236_12100	COG2140	Oxalate decarboxylase
N1236_12125	COG1464	Belongs to the NlpA lipoprotein family
N1236_12130	COG2011	ABC-type metal ion transport system permease component
N1236_12135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N1236_12145	COG0626	cystathionine gamma-synthase activity
N1236_12150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N1236_12190	COG0535	radical SAM domain protein
N1236_12195	COG2873	o-acetylhomoserine
N1236_12200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N1236_12205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N1236_12215	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
N1236_12225	COG0813	purine-nucleoside phosphorylase activity
N1236_12230	COG1744	ABC transporter substrate-binding protein PnrA-like
N1236_12235	COG1328	CTP reductase activity
N1236_12240	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N1236_12245	COG3845	ABC transporter
N1236_12250	COG4603	Belongs to the binding-protein-dependent transport system permease family
N1236_12255	COG1079	Belongs to the binding-protein-dependent transport system permease family
N1236_12260	COG0295	cytidine deaminase activity
N1236_12270	COG2207	Transcriptional regulator
N1236_12270	COG4753	response regulator
N1236_12285	COG3842	ATPase activity
N1236_12340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N1236_12365	COG0577	efflux transmembrane transporter activity
N1236_12365	COG1136	(ABC) transporter
N1236_12370	COG2770	Histidine kinase
N1236_12370	COG2205	protein histidine kinase activity
N1236_12410	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N1236_12425	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N1236_12435	COG0732	type I restriction modification DNA specificity domain
N1236_12440	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N1236_12470	COG1120	ATPase activity
N1236_12475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N1236_12480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N1236_12490	COG0739	heme binding
N1236_12510	COG0577	efflux transmembrane transporter activity
N1236_12520	COG1136	(ABC) transporter
N1236_12560	COG1592	Rubrerythrin
N1236_12570	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N1236_12575	COG1067	ATP-dependent peptidase activity
N1236_12580	COG0456	acetyltransferase
N1236_12585	COG1214	PFAM Peptidase M22, glycoprotease
N1236_12590	COG0802	atpase or kinase
N1236_12595	COG1228	amidohydrolase
N1236_12620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N1236_12625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N1236_12635	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
N1236_12640	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N1236_12650	COG1215	transferase activity, transferring glycosyl groups
N1236_12655	COG0542	response to heat
N1236_12660	COG3869	Catalyzes the specific phosphorylation of arginine residues in
N1236_12665	COG3880	PFAM UvrB UvrC protein
N1236_12690	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
N1236_12695	COG0287	Prephenate dehydrogenase
N1236_12700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N1236_12705	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
N1236_12710	COG0488	(ABC) transporter
N1236_12725	COG1122	ATPase activity
N1236_12735	COG0310	cobalt ion transport
N1236_12740	COG0860	N-Acetylmuramoyl-L-alanine amidase
N1236_12745	COG0745	RESPONSE REGULATOR receiver
N1236_12770	COG1595	DNA-templated transcription, initiation
N1236_12785	COG0829	nickel cation binding
N1236_12790	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N1236_12800	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
N1236_12805	COG0804	urea catabolic process
N1236_12810	COG0832	Belongs to the urease beta subunit family
N1236_12815	COG0831	urea catabolic process
N1236_12845	COG4753	response regulator
N1236_12845	COG2207	Transcriptional regulator
N1236_12855	COG4251	negative regulation of phosphorylation
N1236_12975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N1236_12985	COG1606	tRNA processing
N1236_12995	COG1959	2 iron, 2 sulfur cluster binding
N1236_13000	COG1959	2 iron, 2 sulfur cluster binding
N1236_13005	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
N1236_13010	COG5002	protein histidine kinase activity
N1236_13015	COG0745	RESPONSE REGULATOR receiver
N1236_13020	COG2217	Heavy metal translocating P-type atpase
N1236_13065	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N1236_13070	COG1278	Cold shock
N1236_13075	COG3695	enzyme binding
N1236_13090	COG0793	Belongs to the peptidase S41A family
N1236_13090	COG3409	Peptidoglycan-binding domain 1 protein
N1236_13100	COG2177	Part of the ABC transporter FtsEX involved in
N1236_13105	COG2884	Cell division ATP-binding protein ftsE
N1236_13110	COG3835	regulator
N1236_13115	COG3842	ATPase activity
N1236_13120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N1236_13125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N1236_13135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N1236_13140	COG0505	Belongs to the CarA family
N1236_13145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N1236_13150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N1236_13165	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
N1236_13185	COG1695	Transcriptional regulator
N1236_13190	COG1408	metallophosphoesterase
N1236_13200	COG3328	transposase activity
N1236_13205	COG1876	peptidase activity
N1236_13215	COG3328	transposase activity
N1236_13225	COG0726	polysaccharide deacetylase
N1236_13245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N1236_13245	COG0318	PFAM AMP-dependent synthetase and ligase
N1236_13245	COG0300	oxidoreductase activity
N1236_13245	COG1028	Short-chain dehydrogenase reductase Sdr
N1236_13245	COG3321	synthase
N1236_13255	COG3328	transposase activity
N1236_13300	COG5002	protein histidine kinase activity
N1236_13305	COG0745	RESPONSE REGULATOR receiver
N1236_13310	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N1236_13315	COG1982	Orn Lys Arg decarboxylase major
N1236_13320	COG1285	pathogenesis
N1236_13330	COG1695	Transcriptional regulator
N1236_13340	COG0504	CTP synthase activity
N1236_13370	COG3409	Peptidoglycan-binding domain 1 protein
N1236_13370	COG0793	Belongs to the peptidase S41A family
N1236_13385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N1236_13395	COG0018	arginyl-trna synthetase
N1236_13405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N1236_13410	COG1181	Belongs to the D-alanine--D-alanine ligase family
N1236_13415	COG2239	Acts as a magnesium transporter
N1236_13435	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N1236_13440	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
N1236_13445	COG0492	ferredoxin-NADP+ reductase activity
N1236_13460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N1236_13465	COG0785	Cytochrome C biogenesis protein
N1236_13500	COG2183	response to ionizing radiation
N1236_13525	COG2226	methyltransferase
N1236_13535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N1236_13545	COG3693	PFAM glycoside hydrolase, family 10
N1236_13545	COG3507	Belongs to the glycosyl hydrolase 43 family
N1236_13545	COG2382	esterase
N1236_13550	COG3634	alkyl hydroperoxide reductase activity
N1236_13555	COG0450	alkyl hydroperoxide reductase
N1236_13570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N1236_13800	COG0515	serine threonine protein kinase
N1236_13800	COG0457	Tetratricopeptide repeat
N1236_13805	COG2226	methyltransferase
N1236_13810	COG2226	methyltransferase
N1236_13830	COG1074	ATP-dependent DNA helicase activity
N1236_13835	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
N1236_13935	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
N1236_13955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N1236_13965	COG0697	spore germination
N1236_13980	COG0215	cysteine-tRNA ligase activity
N1236_13985	COG1045	serine acetyltransferase
N1236_14025	COG1473	amidohydrolase
N1236_14030	COG2155	Conserved Protein
N1236_14040	COG0217	transcriptional regulatory protein
N1236_14045	COG5002	protein histidine kinase activity
N1236_14055	COG1739	Uncharacterized protein family UPF0029
N1236_14060	COG0681	Belongs to the peptidase S26 family
N1236_14065	COG0494	nUDIX hydrolase
N1236_14070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N1236_14080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N1236_14085	COG0756	dUTP diphosphatase activity
N1236_14090	COG0826	peptidase U32
N1236_14095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N1236_14105	COG5297	Belongs to the glycosyl hydrolase family 6
N1236_14120	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N1236_14125	COG3583	domain protein
N1236_14125	COG3584	3D domain protein
N1236_14135	COG0084	hydrolase, TatD family'
N1236_14140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N1236_14140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N1236_14150	COG0700	Nucleoside recognition
N1236_14155	COG2715	membrane protein required for spore maturation
N1236_14160	COG2002	toxin-antitoxin pair type II binding
N1236_14165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N1236_14170	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
N1236_14180	COG1774	PSP1 C-terminal conserved region
N1236_14185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N1236_14190	COG1728	Protein conserved in bacteria
N1236_14200	COG1982	Orn Lys Arg decarboxylase major
N1236_14215	COG1136	(ABC) transporter
N1236_14230	COG5002	protein histidine kinase activity
N1236_14240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N1236_14245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N1236_14255	COG3693	PFAM glycoside hydrolase, family 10
N1236_14260	COG1191	sigma factor activity
N1236_14305	COG1175	transmembrane transport
N1236_14310	COG0714	Associated with various cellular activities
N1236_14360	COG3940	Belongs to the glycosyl hydrolase 43 family
N1236_14365	COG3940	Belongs to the glycosyl hydrolase 43 family
N1236_14380	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N1236_14385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N1236_14390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N1236_14395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N1236_14455	COG1361	Conserved repeat domain
N1236_14475	COG3328	transposase activity
N1236_14505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N1236_14520	COG1773	rubredoxin
N1236_14545	COG1408	metallophosphoesterase
N1236_14560	COG0254	rRNA binding
N1236_14565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N1236_14605	COG0038	chloride channel
N1236_14615	COG0037	tRNA processing
N1236_14625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N1236_14630	COG1295	ribonuclease BN
N1236_14635	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N1236_14640	COG0629	single-stranded DNA binding
N1236_14645	COG0360	Binds together with S18 to 16S ribosomal RNA
N1236_14655	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N1236_14660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N1236_14670	COG3693	PFAM glycoside hydrolase, family 10
N1236_14670	COG3507	Belongs to the glycosyl hydrolase 43 family
N1236_14670	COG2382	esterase
N1236_14675	COG3507	Belongs to the glycosyl hydrolase 43 family
N1236_14680	COG3693	PFAM glycoside hydrolase, family 10
N1236_14680	COG3507	Belongs to the glycosyl hydrolase 43 family
N1236_14680	COG2382	esterase
N1236_14685	COG3693	PFAM glycoside hydrolase, family 10
N1236_14685	COG2382	esterase
N1236_14685	COG3507	Belongs to the glycosyl hydrolase 43 family
N1236_14690	COG3507	Belongs to the glycosyl hydrolase 43 family
N1236_14695	COG3250	beta-galactosidase activity
N1236_14710	COG4978	Transcriptional regulator
N1236_14710	COG0789	Transcriptional regulator
N1236_14715	COG0577	efflux transmembrane transporter activity
N1236_14720	COG1136	(ABC) transporter
N1236_14725	COG5002	protein histidine kinase activity
N1236_14730	COG0745	RESPONSE REGULATOR receiver
N1236_14780	COG0302	gtp cyclohydrolase
N1236_14785	COG1181	Belongs to the D-alanine--D-alanine ligase family
N1236_14785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N1236_14790	COG4242	Belongs to the peptidase S51 family
N1236_14800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N1236_14805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N1236_14810	COG0473	3-isopropylmalate dehydrogenase activity
N1236_14815	COG0066	3-isopropylmalate dehydratase activity
N1236_14820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N1236_14825	COG2207	Transcriptional regulator
N1236_14830	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
N1236_14850	COG1516	flagellar protein fliS
N1236_14855	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N1236_14865	COG1088	dTDP-glucose 4,6-dehydratase activity
N1236_14870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N1236_14885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N1236_14900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N1236_14910	COG2089	acid synthase
N1236_14915	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
N1236_14920	COG2226	methyltransferase
N1236_14925	COG1086	Polysaccharide biosynthesis protein
N1236_14945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N1236_14950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N1236_14960	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N1236_14965	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
N1236_14975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N1236_14980	COG4786	Flagellar basal body rod
N1236_14980	COG1256	bacterial-type flagellum assembly
N1236_15005	COG1040	competence protein
N1236_15010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N1236_15020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N1236_15030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N1236_15035	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
N1236_15040	COG0037	tRNA processing
N1236_15045	COG0305	Participates in initiation and elongation during chromosome replication
N1236_15050	COG0359	binds to the 23S rRNA
N1236_15055	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
N1236_15065	COG0077	Prephenate dehydratase
N1236_15065	COG1605	Chorismate mutase
N1236_15075	COG1269	ATP hydrolysis coupled proton transport
N1236_15080	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N1236_15085	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
N1236_15100	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
N1236_15105	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
N1236_15110	COG1394	ATPase activity, coupled to movement of substances
N1236_15115	COG0488	(ABC) transporter
N1236_15155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N1236_15170	COG0765	amino acid transport
N1236_15180	COG2201	protein-glutamate methylesterase activity
N1236_15185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N1236_15195	COG0643	Histidine kinase
N1236_15195	COG2198	Histidine kinase
N1236_15200	COG0835	chemotaxis
N1236_15205	COG0582	viral genome integration into host DNA
N1236_15210	COG2207	Transcriptional regulator
N1236_15210	COG3708	Transcriptional regulator
N1236_15225	COG1131	(ABC) transporter
N1236_15245	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
N1236_15250	COG1518	maintenance of DNA repeat elements
N1236_15290	COG1968	undecaprenyl-diphosphatase activity
N1236_15295	COG0534	Mate efflux family protein
N1236_15340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N1236_15345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N1236_15350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N1236_15370	COG5002	protein histidine kinase activity
N1236_15375	COG0745	RESPONSE REGULATOR receiver
N1236_15395	COG0438	transferase activity, transferring glycosyl groups
N1236_15405	COG0438	transferase activity, transferring glycosyl groups
N1236_15435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N1236_15440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N1236_15455	COG1361	Conserved repeat domain
N1236_15465	COG3773	Cell wall hydrolase
N1236_15475	COG0517	IMP dehydrogenase activity
N1236_15490	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N1236_15495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N1236_15530	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
N1236_15535	COG4733	cellulase activity
N1236_15535	COG4447	cellulose binding
N1236_15540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N1236_15545	COG1475	DNA binding
N1236_15550	COG0357	Ribosomal RNA small subunit methyltransferase G
N1236_15560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N1236_15565	COG1847	R3H domain protein
N1236_15570	COG0706	membrane insertase activity
N1236_15575	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N1236_15585	COG0230	Belongs to the bacterial ribosomal protein bL34 family