locus-tag	class	description
CLOST_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLOST_0002	COG0592	DNA-directed DNA polymerase activity
CLOST_0005	COG0187	DNA topoisomerase II activity
CLOST_0006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLOST_0007	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CLOST_0010	COG1366	Belongs to the anti-sigma-factor antagonist family
CLOST_0011	COG2172	sigma factor antagonist activity
CLOST_0012	COG1191	sigma factor activity
CLOST_0013	COG2199	diguanylate cyclase activity
CLOST_0016	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLOST_0018	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLOST_0020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLOST_0021	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CLOST_0022	COG1309	transcriptional regulator
CLOST_0024	COG4187	Peptidase family M20/M25/M40
CLOST_0027	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CLOST_0030	COG0517	IMP dehydrogenase activity
CLOST_0030	COG1125	glycine betaine transport
CLOST_0032	COG0840	transmembrane signaling receptor activity
CLOST_0035	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CLOST_0037	COG1174	glycine betaine transport
CLOST_0039	COG1174	glycine betaine transport
CLOST_0041	COG0010	Belongs to the arginase family
CLOST_0042	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLOST_0043	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CLOST_0044	COG1982	Orn Lys Arg decarboxylase major
CLOST_0045	COG3457	Alanine racemase
CLOST_0047	COG1785	Belongs to the alkaline phosphatase family
CLOST_0048	COG1615	UPF0182 protein
CLOST_0050	COG1592	Rubrerythrin
CLOST_0051	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLOST_0055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLOST_0056	COG0531	amino acid
CLOST_0061	COG2226	methyltransferase
CLOST_0071	COG0590	tRNA wobble adenosine to inosine editing
CLOST_0073	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLOST_0075	COG3842	ATPase activity
CLOST_0076	COG0523	cobalamin synthesis protein
CLOST_0079	COG5012	cobalamin binding
CLOST_0080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CLOST_0085	COG0444	Belongs to the ABC transporter superfamily
CLOST_0086	COG4608	Belongs to the ABC transporter superfamily
CLOST_0087	COG0747	negative chemotaxis
CLOST_0090	COG2011	ABC-type metal ion transport system permease component
CLOST_0091	COG1464	Belongs to the NlpA lipoprotein family
CLOST_0095	COG1132	(ABC) transporter
CLOST_0096	COG0840	transmembrane signaling receptor activity
CLOST_0097	COG0488	(ABC) transporter
CLOST_0098	COG0826	peptidase U32
CLOST_0099	COG0840	transmembrane signaling receptor activity
CLOST_0100	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CLOST_0101	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CLOST_0103	COG0590	tRNA wobble adenosine to inosine editing
CLOST_0104	COG3706	GGDEF domain
CLOST_0104	COG0745	RESPONSE REGULATOR receiver
CLOST_0106	COG0475	glutathione-regulated potassium exporter activity
CLOST_0106	COG0589	response to stress
CLOST_0108	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLOST_0114	COG1741	Belongs to the pirin family
CLOST_0120	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CLOST_0124	COG2239	Acts as a magnesium transporter
CLOST_0126	COG3447	MASE1 domain protein
CLOST_0126	COG5002	protein histidine kinase activity
CLOST_0126	COG5001	Diguanylate cyclase
CLOST_0128	COG0393	Putative heavy-metal-binding
CLOST_0130	COG0784	Response regulator, receiver
CLOST_0130	COG3437	response regulator, receiver
CLOST_0131	COG2205	protein histidine kinase activity
CLOST_0131	COG0784	Response regulator, receiver
CLOST_0133	COG0488	(ABC) transporter
CLOST_0136	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLOST_0137	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLOST_0138	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CLOST_0139	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLOST_0141	COG0137	argininosuccinate synthase activity
CLOST_0143	COG2827	Endonuclease containing a URI domain
CLOST_0146	COG0840	transmembrane signaling receptor activity
CLOST_0149	COG0671	phosphoesterase, PA-phosphatase related
CLOST_0152	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLOST_0153	COG0482	sulfurtransferase activity
CLOST_0156	COG0783	Belongs to the Dps family
CLOST_0157	COG0346	lactoylglutathione lyase activity
CLOST_0159	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CLOST_0160	COG0542	response to heat
CLOST_0161	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CLOST_0163	COG4956	integral membrane protein (PIN domain superfamily)
CLOST_0167	COG0438	transferase activity, transferring glycosyl groups
CLOST_0171	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLOST_0173	COG0542	response to heat
CLOST_0176	COG0840	transmembrane signaling receptor activity
CLOST_0178	COG1705	Flagellar rod assembly protein muramidase FlgJ
CLOST_0181	COG1288	antiporter activity
CLOST_0184	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLOST_0195	COG1028	Short-chain dehydrogenase reductase Sdr
CLOST_0196	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLOST_0198	COG3246	L-lysine catabolic process to acetate
CLOST_0200	COG3290	protein histidine kinase activity
CLOST_0200	COG3829	transcription factor binding
CLOST_0204	COG0280	phosphate acetyltransferase
CLOST_0209	COG1373	ATPase (AAA superfamily
CLOST_0210	COG0739	heme binding
CLOST_0210	COG0741	lytic transglycosylase activity
CLOST_0210	COG1196	nuclear chromosome segregation
CLOST_0211	COG3876	Protein conserved in bacteria
CLOST_0213	COG1136	(ABC) transporter
CLOST_0217	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOST_0220	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLOST_0221	COG1408	metallophosphoesterase
CLOST_0222	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CLOST_0223	COG1704	LemA family
CLOST_0224	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CLOST_0225	COG1074	ATP-dependent DNA helicase activity
CLOST_0226	COG1307	EDD domain protein, DegV family
CLOST_0230	COG4948	Mandelate Racemase Muconate Lactonizing
CLOST_0231	COG1151	hydroxylamine reductase activity
CLOST_0232	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLOST_0232	COG3153	acetyltransferase
CLOST_0234	COG0840	transmembrane signaling receptor activity
CLOST_0235	COG1316	TRANSCRIPTIONal
CLOST_0237	COG2814	Major facilitator Superfamily
CLOST_0240	COG0745	RESPONSE REGULATOR receiver
CLOST_0241	COG5002	protein histidine kinase activity
CLOST_0242	COG4810	utilization protein
CLOST_0247	COG4303	Ethanolamine ammonia lyase large subunit
CLOST_0248	COG4302	ethanolamine ammonia-lyase activity
CLOST_0249	COG4816	utilization protein
CLOST_0250	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLOST_0251	COG1454	alcohol dehydrogenase
CLOST_0251	COG1012	belongs to the aldehyde dehydrogenase family
CLOST_0252	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLOST_0254	COG4869	propanediol catabolic process
CLOST_0256	COG3192	ethanolamine utilization protein
CLOST_0258	COG4820	ethanolamine utilization protein (EutJ)
CLOST_0259	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CLOST_0260	COG4656	Part of a membrane complex involved in electron transport
CLOST_0263	COG4535	Mg2 and Co2 transporter CorC
CLOST_0270	COG1122	ATPase activity
CLOST_0274	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLOST_0276	COG0543	2 iron, 2 sulfur cluster binding
CLOST_0281	COG0737	Belongs to the 5'-nucleotidase family
CLOST_0284	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLOST_0286	COG0459	protein refolding
CLOST_0287	COG1691	(AIR) carboxylase
CLOST_0288	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CLOST_0289	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLOST_0290	COG1132	(ABC) transporter
CLOST_0292	COG1132	(ABC) transporter
CLOST_0296	COG0517	IMP dehydrogenase activity
CLOST_0296	COG0516	GMP reductase activity
CLOST_0300	COG0582	viral genome integration into host DNA
CLOST_0320	COG1704	LemA family
CLOST_0323	COG1192	Involved in chromosome partitioning
CLOST_0328	COG2321	neutral zinc metallopeptidase
CLOST_0329	COG0693	protein deglycase activity
CLOST_0331	COG5278	phosphoserine phosphatase activity
CLOST_0331	COG0840	transmembrane signaling receptor activity
CLOST_0332	COG2252	PERMEase
CLOST_0333	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLOST_0334	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLOST_0335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLOST_0336	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLOST_0337	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLOST_0339	COG0151	Belongs to the GarS family
CLOST_0340	COG0840	transmembrane signaling receptor activity
CLOST_0341	COG3956	TIGRFAM MazG family protein
CLOST_0342	COG0776	regulation of translation
CLOST_0343	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLOST_0350	COG4196	transglutaminase domain protein
CLOST_0351	COG0793	Belongs to the peptidase S41A family
CLOST_0351	COG3409	Peptidoglycan-binding domain 1 protein
CLOST_0359	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLOST_0360	COG0367	asparagine synthase
CLOST_0362	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLOST_0364	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLOST_0365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLOST_0367	COG2089	acid synthase
CLOST_0368	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLOST_0369	COG1083	cytidylyl-transferase
CLOST_0370	COG0728	peptidoglycan biosynthetic process
CLOST_0381	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CLOST_0384	COG0443	Heat shock 70 kDa protein
CLOST_0386	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CLOST_0387	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CLOST_0395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLOST_0396	COG0531	amino acid
CLOST_0398	COG0140	phosphoribosyl-ATP diphosphatase activity
CLOST_0399	COG5001	Diguanylate cyclase
CLOST_0406	COG0840	transmembrane signaling receptor activity
CLOST_0407	COG0840	transmembrane signaling receptor activity
CLOST_0408	COG3237	CsbD-like
CLOST_0409	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CLOST_0411	COG0307	riboflavin synthase, alpha
CLOST_0412	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLOST_0412	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLOST_0413	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CLOST_0414	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLOST_0415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLOST_0417	COG0473	3-isopropylmalate dehydrogenase activity
CLOST_0418	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLOST_0420	COG1846	Transcriptional regulator
CLOST_0423	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLOST_0426	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLOST_0427	COG0509	glycine decarboxylation via glycine cleavage system
CLOST_0428	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLOST_0429	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLOST_0430	COG0436	Aminotransferase
CLOST_0431	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLOST_0432	COG2234	aminopeptidase activity
CLOST_0434	COG0019	diaminopimelate decarboxylase activity
CLOST_0443	COG0110	maltose O-acetyltransferase activity
CLOST_0444	COG0463	Glycosyl transferase, family 2
CLOST_0450	COG3103	Sh3 type 3 domain protein
CLOST_0450	COG1388	LysM domain
CLOST_0450	COG0791	NLP P60 protein
CLOST_0452	COG1136	(ABC) transporter
CLOST_0453	COG0577	efflux transmembrane transporter activity
CLOST_0455	COG1309	transcriptional regulator
CLOST_0456	COG1566	PFAM secretion protein HlyD family protein
CLOST_0460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLOST_0462	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CLOST_0463	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLOST_0464	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOST_0464	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOST_0465	COG0084	hydrolase, TatD family'
CLOST_0470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLOST_0475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLOST_0476	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLOST_0477	COG0315	cyclic pyranopterin monophosphate synthase activity
CLOST_0478	COG2244	polysaccharide biosynthetic process
CLOST_0484	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CLOST_0486	COG3426	butyrate kinase activity
CLOST_0487	COG0280	phosphate acetyltransferase
CLOST_0491	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLOST_0494	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOST_0504	COG5592	hemerythrin HHE cation binding domain
CLOST_0505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLOST_0507	COG0556	nucleotide-excision repair
CLOST_0520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CLOST_0521	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLOST_0523	COG0131	Imidazoleglycerol-phosphate dehydratase
CLOST_0524	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLOST_0528	COG0140	phosphoribosyl-ATP diphosphatase activity
CLOST_0528	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLOST_0530	COG0681	Belongs to the peptidase S26 family
CLOST_0531	COG0390	transport system, permease component
CLOST_0532	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLOST_0535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLOST_0536	COG0251	oxidation-reduction process
CLOST_0537	COG0673	inositol 2-dehydrogenase activity
CLOST_0538	COG1879	ABC-type sugar transport system periplasmic component
CLOST_0539	COG2972	Histidine kinase
CLOST_0541	COG4213	ABC transporter substrate-binding protein
CLOST_0542	COG4213	ABC transporter substrate-binding protein
CLOST_0544	COG4214	carbohydrate transport
CLOST_0546	COG1811	Na channel or pump
CLOST_0549	COG1940	carbohydrate kinase activity
CLOST_0553	COG4667	esterase of the alpha-beta hydrolase superfamily
CLOST_0555	COG0210	DNA helicase
CLOST_0556	COG1362	aminopeptidase activity
CLOST_0566	COG2268	Band 7 protein
CLOST_0567	COG2217	Heavy metal translocating P-type atpase
CLOST_0569	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLOST_0570	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOST_0573	COG1597	lipid kinase activity
CLOST_0574	COG3706	GGDEF domain
CLOST_0575	COG1741	Belongs to the pirin family
CLOST_0576	COG0534	Mate efflux family protein
CLOST_0580	COG2890	protein-(glutamine-N5) methyltransferase activity
CLOST_0581	COG0601	transmembrane transport
CLOST_0582	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOST_0583	COG0444	Belongs to the ABC transporter superfamily
CLOST_0584	COG4608	Belongs to the ABC transporter superfamily
CLOST_0585	COG4166	transmembrane transport
CLOST_0586	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CLOST_0589	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLOST_0591	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLOST_0597	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLOST_0599	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CLOST_0600	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLOST_0603	COG1653	transport
CLOST_0604	COG1301	dicarboxylic acid transport
CLOST_0605	COG1121	(ABC) transporter
CLOST_0606	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLOST_0608	COG0840	transmembrane signaling receptor activity
CLOST_0609	COG0840	transmembrane signaling receptor activity
CLOST_0610	COG0840	transmembrane signaling receptor activity
CLOST_0612	COG0573	inorganic phosphate transmembrane transporter activity
CLOST_0613	COG0581	inorganic phosphate transmembrane transporter activity
CLOST_0614	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLOST_0615	COG0704	Plays a role in the regulation of phosphate uptake
CLOST_0616	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLOST_0622	COG0525	valine-tRNA ligase activity
CLOST_0623	COG0285	dihydrofolate synthase activity
CLOST_0626	COG2226	methyltransferase
CLOST_0629	COG1473	amidohydrolase
CLOST_0636	COG0675	Transposase, IS605 OrfB family
CLOST_0637	COG2226	methyltransferase
CLOST_0639	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLOST_0640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLOST_0641	COG2390	Transcriptional regulator
CLOST_0643	COG0126	phosphoglycerate kinase activity
CLOST_0644	COG0149	triose-phosphate isomerase activity
CLOST_0646	COG0148	phosphopyruvate hydratase activity
CLOST_0649	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLOST_0650	COG0287	Prephenate dehydrogenase
CLOST_0651	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLOST_0652	COG1605	Chorismate mutase
CLOST_0652	COG0077	Prephenate dehydratase
CLOST_0654	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLOST_0655	COG0557	exoribonuclease II activity
CLOST_0659	COG2203	Gaf domain
CLOST_0659	COG2199	diguanylate cyclase activity
CLOST_0660	COG3706	GGDEF domain
CLOST_0660	COG2203	Gaf domain
CLOST_0660	COG5001	Diguanylate cyclase
CLOST_0660	COG4251	negative regulation of phosphorylation
CLOST_0661	COG3290	protein histidine kinase activity
CLOST_0661	COG3829	transcription factor binding
CLOST_0662	COG1288	antiporter activity
CLOST_0663	COG1288	antiporter activity
CLOST_0664	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CLOST_0665	COG3300	MHYT domain
CLOST_0665	COG5001	Diguanylate cyclase
CLOST_0667	COG1307	EDD domain protein, DegV family
CLOST_0669	COG3706	GGDEF domain
CLOST_0671	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOST_0672	COG1349	DNA-binding transcription factor activity
CLOST_0673	COG0235	Class ii aldolase
CLOST_0676	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLOST_0678	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLOST_0679	COG4869	propanediol catabolic process
CLOST_0680	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CLOST_0682	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOST_0686	COG1129	ABC transporter
CLOST_0687	COG4214	carbohydrate transport
CLOST_0688	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CLOST_0689	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CLOST_0690	COG2203	Gaf domain
CLOST_0690	COG4251	negative regulation of phosphorylation
CLOST_0690	COG5001	Diguanylate cyclase
CLOST_0690	COG3706	GGDEF domain
CLOST_0693	COG0598	Magnesium transport protein CorA
CLOST_0700	COG1032	radical SAM domain protein
CLOST_0702	COG2226	methyltransferase
CLOST_0707	COG4325	translation initiation factor activity
CLOST_0709	COG1342	Belongs to the UPF0251 family
CLOST_0712	COG0312	modulator of DNA gyrase
CLOST_0715	COG2207	Transcriptional regulator
CLOST_0715	COG3708	Transcriptional regulator
CLOST_0718	COG4895	conserved protein (DUF2196)
CLOST_0722	COG2357	RelA SpoT domain protein
CLOST_0723	COG0813	purine-nucleoside phosphorylase activity
CLOST_0724	COG0322	excinuclease ABC activity
CLOST_0725	COG2161	toxin-antitoxin pair type II binding
CLOST_0728	COG3437	response regulator, receiver
CLOST_0743	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLOST_0746	COG0420	3'-5' exonuclease activity
CLOST_0747	COG0419	ATPase involved in DNA repair
CLOST_0750	COG3118	belongs to the thioredoxin family
CLOST_0751	COG3706	GGDEF domain
CLOST_0761	COG0840	transmembrane signaling receptor activity
CLOST_0763	COG0701	Predicted permease
CLOST_0764	COG0640	Transcriptional regulator
CLOST_0768	COG0798	PFAM Bile acid sodium symporter
CLOST_0769	COG3706	GGDEF domain
CLOST_0769	COG5001	Diguanylate cyclase
CLOST_0769	COG4251	negative regulation of phosphorylation
CLOST_0769	COG2203	Gaf domain
CLOST_0770	COG1609	Transcriptional regulator
CLOST_0771	COG1129	ABC transporter
CLOST_0772	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOST_0774	COG1063	alcohol dehydrogenase
CLOST_0775	COG1070	Carbohydrate kinase
CLOST_0777	COG4134	Bacterial extracellular solute-binding protein
CLOST_0778	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLOST_0780	COG3842	ATPase activity
CLOST_0783	COG0398	Pfam SNARE associated Golgi protein
CLOST_0787	COG1136	(ABC) transporter
CLOST_0790	COG1132	(ABC) transporter
CLOST_0791	COG1132	(ABC) transporter
CLOST_0801	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLOST_0802	COG0569	domain protein
CLOST_0802	COG2985	domain, Protein
CLOST_0803	COG0006	proline dipeptidase activity
CLOST_0804	COG1228	amidohydrolase
CLOST_0823	COG1982	Orn Lys Arg decarboxylase major
CLOST_0824	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLOST_0824	COG0551	DNA topoisomerase type I activity
CLOST_0827	COG2414	aldehyde ferredoxin oxidoreductase
CLOST_0830	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOST_0831	COG5001	Diguanylate cyclase
CLOST_0831	COG3300	MHYT domain
CLOST_0833	COG0275	rRNA processing
CLOST_0836	COG0303	'Molybdopterin
CLOST_0837	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CLOST_0838	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOST_0840	COG1910	domain protein
CLOST_0843	COG0653	protein targeting
CLOST_0847	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLOST_0850	COG0714	Associated with various cellular activities
CLOST_0852	COG1305	Transglutaminase-like
CLOST_0855	COG1078	dGTPase activity
CLOST_0863	COG0316	Belongs to the HesB IscA family
CLOST_0864	COG2309	aminopeptidase activity
CLOST_0865	COG1278	Cold shock
CLOST_0866	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLOST_0869	COG0745	RESPONSE REGULATOR receiver
CLOST_0870	COG5002	protein histidine kinase activity
CLOST_0870	COG3850	Histidine kinase
CLOST_0876	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CLOST_0878	COG0601	transmembrane transport
CLOST_0879	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOST_0881	COG4608	Belongs to the ABC transporter superfamily
CLOST_0882	COG3437	response regulator, receiver
CLOST_0883	COG0739	heme binding
CLOST_0885	COG3852	Histidine kinase
CLOST_0887	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CLOST_0890	COG0439	Biotin carboxylase
CLOST_0891	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLOST_0893	COG1846	Transcriptional regulator
CLOST_0894	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLOST_0895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLOST_0896	COG2070	2-Nitropropane dioxygenase
CLOST_0897	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLOST_0899	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLOST_0900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLOST_0901	COG0460	homoserine dehydrogenase
CLOST_0904	COG0248	Ppx GppA phosphatase
CLOST_0906	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CLOST_0910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLOST_0912	COG0564	pseudouridine synthase activity
CLOST_0913	COG2119	membrane
CLOST_0916	COG1242	4 iron, 4 sulfur cluster binding
CLOST_0920	COG2357	RelA SpoT domain protein
CLOST_0922	COG0205	6-phosphofructokinase activity
CLOST_0923	COG2313	pseudouridylate synthase activity
CLOST_0924	COG2223	nitrite transmembrane transporter activity
CLOST_0925	COG0789	Transcriptional regulator
CLOST_0926	COG2235	arginine
CLOST_0927	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLOST_0928	COG0549	Belongs to the carbamate kinase family
CLOST_0932	COG1802	Transcriptional regulator
CLOST_0933	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLOST_0934	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLOST_0937	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLOST_0939	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLOST_0939	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLOST_0941	COG0346	lactoylglutathione lyase activity
CLOST_0942	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CLOST_0944	COG4770	biotin carboxylase activity
CLOST_0945	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CLOST_0947	COG3191	aminopeptidase activity
CLOST_0952	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLOST_0955	COG1492	cobalamin metabolic process
CLOST_0956	COG1328	CTP reductase activity
CLOST_0962	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOST_0964	COG1288	antiporter activity
CLOST_0965	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOST_0967	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLOST_0968	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLOST_0970	COG0058	SHG alpha-glucan phosphorylase activity
CLOST_0976	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CLOST_0977	COG1846	Transcriptional regulator
CLOST_0978	COG0386	Belongs to the glutathione peroxidase family
CLOST_0981	COG1797	cobyrinic acid a,c-diamide synthase activity
CLOST_0985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLOST_0988	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CLOST_0989	COG2241	protein methyltransferase activity
CLOST_0992	COG2875	Belongs to the precorrin methyltransferase family
CLOST_0996	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CLOST_0997	COG1648	precorrin-2 dehydrogenase activity
CLOST_0997	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLOST_0998	COG0181	hydroxymethylbilane synthase activity
CLOST_1000	COG0113	porphobilinogen synthase activity
CLOST_1001	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLOST_1006	COG1609	Transcriptional regulator
CLOST_1007	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLOST_1012	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CLOST_1013	COG0697	spore germination
CLOST_1015	COG0037	tRNA processing
CLOST_1018	COG0745	RESPONSE REGULATOR receiver
CLOST_1019	COG2205	protein histidine kinase activity
CLOST_1021	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CLOST_1023	COG1051	belongs to the nudix hydrolase family
CLOST_1026	COG2364	Membrane
CLOST_1027	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLOST_1030	COG3177	Filamentation induced by cAMP protein fic
CLOST_1036	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLOST_1041	COG0124	histidyl-tRNA synthetase
CLOST_1043	COG1396	sequence-specific DNA binding
CLOST_1044	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLOST_1048	COG5001	Diguanylate cyclase
CLOST_1051	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLOST_1052	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CLOST_1059	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLOST_1068	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CLOST_1072	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLOST_1075	COG1966	Carbon starvation protein
CLOST_1077	COG3279	Response regulator of the LytR AlgR family
CLOST_1078	COG3275	phosphorelay sensor kinase activity
CLOST_1080	COG2364	Membrane
CLOST_1081	COG3290	protein histidine kinase activity
CLOST_1081	COG3829	transcription factor binding
CLOST_1083	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLOST_1087	COG0483	inositol monophosphate 1-phosphatase activity
CLOST_1089	COG1659	Linocin_M18 bacteriocin protein
CLOST_1090	COG3384	dioxygenase
CLOST_1093	COG0681	Belongs to the peptidase S26 family
CLOST_1095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLOST_1098	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLOST_1099	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLOST_1100	COG2720	vancomycin resistance protein
CLOST_1103	COG0406	alpha-ribazole phosphatase activity
CLOST_1104	COG0561	phosphatase activity
CLOST_1105	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLOST_1106	COG1307	EDD domain protein, DegV family
CLOST_1109	COG3118	belongs to the thioredoxin family
CLOST_1117	COG1744	ABC transporter substrate-binding protein PnrA-like
CLOST_1123	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CLOST_1129	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CLOST_1130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CLOST_1132	COG1024	Enoyl-CoA hydratase
CLOST_1135	COG1960	acyl-CoA dehydrogenase activity
CLOST_1136	COG2086	electron transfer activity
CLOST_1137	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLOST_1139	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLOST_1140	COG0569	domain protein
CLOST_1141	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLOST_1142	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLOST_1143	COG0072	phenylalanine-tRNA ligase activity
CLOST_1143	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLOST_1144	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CLOST_1145	COG0826	peptidase U32
CLOST_1146	COG1193	negative regulation of DNA recombination
CLOST_1153	COG1032	radical SAM domain protein
CLOST_1155	COG0280	phosphate acetyltransferase
CLOST_1158	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLOST_1160	COG1151	hydroxylamine reductase activity
CLOST_1163	COG3404	Formiminotransferase-cyclodeaminase
CLOST_1166	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLOST_1179	COG0210	DNA helicase
CLOST_1187	COG0651	ATP synthesis coupled electron transport
CLOST_1190	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CLOST_1192	COG0191	fructose-bisphosphate aldolase activity
CLOST_1193	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLOST_1193	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CLOST_1194	COG1187	pseudouridine synthase activity
CLOST_1196	COG3586	endonuclease activity
CLOST_1198	COG4086	secreted protein
CLOST_1199	COG1671	Belongs to the UPF0178 family
CLOST_1201	COG3842	ATPase activity
CLOST_1202	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLOST_1203	COG1177	transmembrane transport
CLOST_1204	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CLOST_1208	COG2270	Major facilitator Superfamily
CLOST_1216	COG3842	ATPase activity
CLOST_1219	COG0531	amino acid
CLOST_1220	COG1393	Belongs to the ArsC family
CLOST_1229	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLOST_1231	COG1923	regulation of RNA biosynthetic process
CLOST_1233	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CLOST_1235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLOST_1237	COG4974	Belongs to the 'phage' integrase family
CLOST_1238	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CLOST_1243	COG0473	3-isopropylmalate dehydrogenase activity
CLOST_1244	COG0372	Belongs to the citrate synthase family
CLOST_1245	COG4974	Belongs to the 'phage' integrase family
CLOST_1248	COG0582	viral genome integration into host DNA
CLOST_1256	COG0514	ATP-dependent DNA helicase (RecQ)
CLOST_1268	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLOST_1283	COG3404	Formiminotransferase-cyclodeaminase
CLOST_1284	COG1228	amidohydrolase
CLOST_1285	COG2431	L-lysine efflux transmembrane transporter activity
CLOST_1288	COG3457	Alanine racemase
CLOST_1290	COG5012	cobalamin binding
CLOST_1292	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLOST_1294	COG3804	dihydrodipicolinate reductase
CLOST_1295	COG3829	transcription factor binding
CLOST_1300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLOST_1302	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLOST_1303	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLOST_1304	COG1490	D-aminoacyl-tRNA deacylase activity
CLOST_1305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLOST_1307	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLOST_1307	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLOST_1310	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLOST_1311	COG1862	Preprotein translocase
CLOST_1312	COG0343	queuine tRNA-ribosyltransferase activity
CLOST_1314	COG2385	sporulation resulting in formation of a cellular spore
CLOST_1314	COG2247	cell wall binding repeat
CLOST_1317	COG0632	four-way junction helicase activity
CLOST_1318	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CLOST_1319	COG0534	Mate efflux family protein
CLOST_1320	COG1846	Transcriptional regulator
CLOST_1321	COG0823	Involved in the tonB-independent uptake of proteins
CLOST_1321	COG1506	peptidase
CLOST_1321	COG4946	Tricorn protease homolog
CLOST_1323	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLOST_1325	COG1739	Uncharacterized protein family UPF0029
CLOST_1327	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLOST_1331	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLOST_1337	COG0463	Glycosyl transferase, family 2
CLOST_1340	COG0497	DNA recombination
CLOST_1341	COG1438	arginine binding
CLOST_1342	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CLOST_1343	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLOST_1344	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CLOST_1348	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLOST_1349	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLOST_1350	COG1302	Protein conserved in bacteria
CLOST_1351	COG0416	fatty acid biosynthetic process
CLOST_1353	COG1399	metal-binding, possibly nucleic acid-binding protein
CLOST_1354	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLOST_1356	COG0745	RESPONSE REGULATOR receiver
CLOST_1360	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CLOST_1361	COG1596	polysaccharide export
CLOST_1361	COG1555	photosystem II stabilization
CLOST_1362	COG1686	Belongs to the peptidase S11 family
CLOST_1364	COG1760	l-serine dehydratase
CLOST_1365	COG1760	l-serine dehydratase
CLOST_1366	COG0799	negative regulation of ribosome biogenesis
CLOST_1367	COG1316	TRANSCRIPTIONal
CLOST_1368	COG1713	HD superfamily hydrolase involved in NAD metabolism
CLOST_1374	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLOST_1375	COG1530	ribonuclease E activity
CLOST_1378	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLOST_1379	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CLOST_1380	COG1193	negative regulation of DNA recombination
CLOST_1382	COG1509	lysine 2,3-aminomutase activity
CLOST_1383	COG0604	alcohol dehydrogenase
CLOST_1384	COG3246	L-lysine catabolic process to acetate
CLOST_1385	COG1607	acyl-coa hydrolase
CLOST_1386	COG1803	Methylglyoxal synthase
CLOST_1387	COG0772	Belongs to the SEDS family
CLOST_1388	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CLOST_1389	COG2894	cell division
CLOST_1390	COG2894	cell division
CLOST_1391	COG0850	regulation of cytokinetic process
CLOST_1392	COG0768	penicillin binding
CLOST_1395	COG2003	Belongs to the UPF0758 family
CLOST_1396	COG0424	maF-like protein
CLOST_1397	COG2878	Part of a membrane complex involved in electron transport
CLOST_1397	COG1245	4Fe-4S binding domain
CLOST_1398	COG4657	Part of a membrane complex involved in electron transport
CLOST_1399	COG4660	Part of a membrane complex involved in electron transport
CLOST_1400	COG4659	FMN binding
CLOST_1401	COG4658	electron transport chain
CLOST_1402	COG4656	Part of a membrane complex involved in electron transport
CLOST_1403	COG0791	NLP P60 protein
CLOST_1405	COG0741	lytic transglycosylase activity
CLOST_1406	COG0237	dephospho-CoA kinase activity
CLOST_1407	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLOST_1407	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLOST_1413	COG0527	aspartate kinase activity
CLOST_1415	COG1477	protein flavinylation
CLOST_1419	COG1252	NADH dehydrogenase
CLOST_1421	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLOST_1422	COG0129	dihydroxy-acid dehydratase activity
CLOST_1423	COG0028	Belongs to the TPP enzyme family
CLOST_1424	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLOST_1425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLOST_1427	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLOST_1431	COG0463	Glycosyl transferase, family 2
CLOST_1432	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLOST_1434	COG0583	DNA-binding transcription factor activity
CLOST_1435	COG2391	methyltransferase activity
CLOST_1437	COG2391	methyltransferase activity
CLOST_1439	COG0243	molybdopterin cofactor binding
CLOST_1442	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOST_1445	COG1104	cysteine desulfurase activity
CLOST_1448	COG1924	4 iron, 4 sulfur cluster binding
CLOST_1449	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CLOST_1450	COG2081	HI0933 family
CLOST_1452	COG0287	Prephenate dehydrogenase
CLOST_1452	COG1605	Chorismate mutase
CLOST_1453	COG0849	cell division
CLOST_1454	COG0583	DNA-binding transcription factor activity
CLOST_1455	COG1362	aminopeptidase activity
CLOST_1457	COG3103	Sh3 type 3 domain protein
CLOST_1457	COG1388	LysM domain
CLOST_1457	COG0791	NLP P60 protein
CLOST_1462	COG1773	rubredoxin
CLOST_1463	COG2359	stage V sporulation protein S
CLOST_1464	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLOST_1465	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLOST_1465	COG0539	negative regulation of cytoplasmic translation
CLOST_1466	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLOST_1468	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLOST_1472	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLOST_1473	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLOST_1473	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLOST_1477	COG1187	pseudouridine synthase activity
CLOST_1478	COG1396	sequence-specific DNA binding
CLOST_1480	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLOST_1481	COG1994	Peptidase M50
CLOST_1482	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLOST_1485	COG0735	belongs to the Fur family
CLOST_1488	COG0667	Aldo Keto reductase
CLOST_1490	COG4472	Bacterial protein of unknown function (DUF965)
CLOST_1493	COG0822	iron-sulfur transferase activity
CLOST_1495	COG1959	2 iron, 2 sulfur cluster binding
CLOST_1496	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLOST_1498	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLOST_1499	COG0758	DNA mediated transformation
CLOST_1504	COG1705	Flagellar rod assembly protein muramidase FlgJ
CLOST_1516	COG3409	Peptidoglycan-binding domain 1 protein
CLOST_1516	COG5632	N-Acetylmuramoyl-L-alanine amidase
CLOST_1532	COG5484	DNA packaging
CLOST_1532	COG3728	DNA packaging
CLOST_1541	COG0629	single-stranded DNA binding
CLOST_1549	COG3935	DnaD domain protein
CLOST_1552	COG1196	nuclear chromosome segregation
CLOST_1559	COG3561	AntA/AntB antirepressor
CLOST_1568	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CLOST_1569	COG0606	chelatase, subunit chli
CLOST_1570	COG0792	nuclease activity
CLOST_1578	COG1837	Belongs to the UPF0109 family
CLOST_1579	COG0228	four-way junction DNA binding
CLOST_1580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLOST_1581	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CLOST_1582	COG0552	protein localization to endoplasmic reticulum
CLOST_1585	COG0571	ribonuclease III activity
CLOST_1588	COG0784	Response regulator, receiver
CLOST_1588	COG0835	chemotaxis
CLOST_1589	COG0756	dUTP diphosphatase activity
CLOST_1590	COG1115	amino acid carrier protein
CLOST_1591	COG1794	racemase activity, acting on amino acids and derivatives
CLOST_1595	COG0710	3-dehydroquinate dehydratase activity
CLOST_1596	COG1970	mechanosensitive ion channel activity
CLOST_1598	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLOST_1601	COG5002	protein histidine kinase activity
CLOST_1602	COG0745	RESPONSE REGULATOR receiver
CLOST_1605	COG1126	abc transporter atp-binding protein
CLOST_1606	COG0765	amino acid transport
CLOST_1607	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOST_1608	COG0572	uridine kinase
CLOST_1611	COG1131	(ABC) transporter
CLOST_1612	COG1725	Transcriptional regulator
CLOST_1613	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLOST_1614	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLOST_1618	COG0697	spore germination
CLOST_1620	COG0156	8-amino-7-oxononanoate synthase activity
CLOST_1623	COG2201	protein-glutamate methylesterase activity
CLOST_1626	COG0346	lactoylglutathione lyase activity
CLOST_1633	COG1131	(ABC) transporter
CLOST_1635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLOST_1645	COG0733	neurotransmitter:sodium symporter activity
CLOST_1648	COG0205	6-phosphofructokinase activity
CLOST_1650	COG1464	Belongs to the NlpA lipoprotein family
CLOST_1651	COG2011	ABC-type metal ion transport system permease component
CLOST_1652	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLOST_1653	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLOST_1654	COG1481	regulation of sporulation
CLOST_1656	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CLOST_1662	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLOST_1664	COG1242	4 iron, 4 sulfur cluster binding
CLOST_1665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLOST_1667	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
CLOST_1668	COG0310	cobalt ion transport
CLOST_1669	COG3443	Belongs to the bacterial solute-binding protein 9 family
CLOST_1669	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLOST_1670	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CLOST_1680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLOST_1682	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CLOST_1683	COG1674	ftsk spoiiie
CLOST_1684	COG1185	polyribonucleotide nucleotidyltransferase activity
CLOST_1685	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLOST_1686	COG0196	riboflavin kinase activity
CLOST_1687	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLOST_1691	COG1358	cellular component organization or biogenesis
CLOST_1693	COG0195	Participates in both transcription termination and antitermination
CLOST_1697	COG0750	zinc metalloprotease
CLOST_1699	COG4589	Belongs to the CDS family
CLOST_1702	COG0233	cytoplasmic translational termination
CLOST_1703	COG0528	UMP kinase activity
CLOST_1709	COG1191	sigma factor activity
CLOST_1711	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CLOST_1712	COG1776	CheC inhibitor of MCP methylation
CLOST_1713	COG0835	chemotaxis
CLOST_1714	COG2198	Histidine kinase
CLOST_1714	COG0643	Histidine kinase
CLOST_1715	COG2201	protein-glutamate methylesterase activity
CLOST_1717	COG0455	bacterial-type flagellum organization
CLOST_1718	COG1419	protein localization to endoplasmic reticulum
CLOST_1719	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLOST_1720	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLOST_1721	COG1684	flagellar biosynthetic protein fliR
CLOST_1722	COG1987	bacterial-type flagellum assembly
CLOST_1723	COG1338	Plays a role in the flagellum-specific transport system
CLOST_1725	COG2201	protein-glutamate methylesterase activity
CLOST_1726	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOST_1726	COG1776	CheC inhibitor of MCP methylation
CLOST_1727	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOST_1734	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CLOST_1735	COG3144	bacterial-type flagellum assembly
CLOST_1738	COG1157	protein secretion by the type III secretion system
CLOST_1740	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLOST_1742	COG1677	Flagellar hook-basal body complex protein FliE
CLOST_1743	COG1558	bacterial-type flagellum-dependent cell motility
CLOST_1745	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CLOST_1746	COG1177	transmembrane transport
CLOST_1747	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLOST_1748	COG3842	ATPase activity
CLOST_1750	COG0116	Belongs to the methyltransferase superfamily
CLOST_1751	COG1606	tRNA processing
CLOST_1754	COG2384	SAM-dependent methyltransferase
CLOST_1755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLOST_1756	COG0358	DNA primase activity
CLOST_1757	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLOST_1758	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLOST_1760	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLOST_1763	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CLOST_1764	COG0512	Glutamine amidotransferase of anthranilate synthase
CLOST_1765	COG4492	Belongs to the UPF0735 family
CLOST_1766	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLOST_1767	COG0574	Belongs to the PEP-utilizing enzyme family
CLOST_1767	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLOST_1769	COG0517	IMP dehydrogenase activity
CLOST_1775	COG0295	cytidine deaminase activity
CLOST_1776	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CLOST_1777	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLOST_1778	COG1702	phosphate starvation-inducible protein PhoH
CLOST_1779	COG2033	superoxide reductase activity
CLOST_1780	COG1098	S1 RNA binding domain
CLOST_1783	COG4864	UPF0365 protein
CLOST_1784	COG1030	water channel activity
CLOST_1786	COG1610	YqeY-like protein
CLOST_1788	COG0537	adenosine 5'-monophosphoramidase activity
CLOST_1789	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLOST_1790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLOST_1791	COG2264	protein methyltransferase activity
CLOST_1793	COG0443	Heat shock 70 kDa protein
CLOST_1794	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLOST_1796	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLOST_1797	COG0785	Cytochrome C biogenesis protein
CLOST_1799	COG0157	Belongs to the NadC ModD family
CLOST_1801	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CLOST_1806	COG0658	competence protein
CLOST_1806	COG2333	competence protein COMEC
CLOST_1813	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLOST_1814	COG1058	Belongs to the CinA family
CLOST_1814	COG1546	Belongs to the CinA family
CLOST_1815	COG2070	2-Nitropropane dioxygenase
CLOST_1816	COG2154	pterin-4-alpha-carbinolamine dehydratase
CLOST_1821	COG2732	(Barnase) inhibitor
CLOST_1824	COG1187	pseudouridine synthase activity
CLOST_1825	COG1120	ATPase activity
CLOST_1826	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOST_1828	COG2171	N-acyltransferase activity
CLOST_1829	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLOST_1830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLOST_1831	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLOST_1832	COG5001	Diguanylate cyclase
CLOST_1832	COG3300	MHYT domain
CLOST_1835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLOST_1839	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLOST_1840	COG0742	ribosomal rna small subunit methyltransferase
CLOST_1841	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLOST_1843	COG1461	Dihydroxyacetone kinase
CLOST_1844	COG1302	Protein conserved in bacteria
CLOST_1845	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLOST_1847	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLOST_1848	COG1162	GTPase activity
CLOST_1849	COG0515	serine threonine protein kinase
CLOST_1849	COG2815	serine threonine protein kinase
CLOST_1850	COG0631	protein serine/threonine phosphatase activity
CLOST_1851	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLOST_1852	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLOST_1852	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLOST_1853	COG2738	Putative neutral zinc metallopeptidase
CLOST_1857	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLOST_1858	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLOST_1861	COG2052	Domain of unknown function (DUF370)
CLOST_1862	COG1561	YicC-like family, N-terminal region
CLOST_1863	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLOST_1865	COG1295	ribonuclease BN
CLOST_1869	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CLOST_1870	COG0564	pseudouridine synthase activity
CLOST_1873	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLOST_1876	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLOST_1877	COG3599	regulation of cell shape
CLOST_1878	COG2302	S4 RNA-binding domain
CLOST_1879	COG0762	integral membrane protein
CLOST_1880	COG1799	cell septum assembly
CLOST_1881	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLOST_1883	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLOST_1884	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CLOST_1885	COG1160	GTP binding
CLOST_1887	COG5002	protein histidine kinase activity
CLOST_1888	COG0745	RESPONSE REGULATOR receiver
CLOST_1889	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLOST_1890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CLOST_1891	COG3856	small basic protein
CLOST_1892	COG3879	Bacterial protein of unknown function (DUF881)
CLOST_1894	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CLOST_1896	COG0772	Belongs to the SEDS family
CLOST_1897	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLOST_1898	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLOST_1899	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLOST_1900	COG0768	penicillin binding
CLOST_1904	COG0612	Peptidase, M16
CLOST_1906	COG0012	GTP binding
CLOST_1910	COG0210	DNA helicase
CLOST_1912	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLOST_1913	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLOST_1913	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLOST_1913	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLOST_1913	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLOST_1914	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CLOST_1915	COG4869	propanediol catabolic process
CLOST_1920	COG2096	Adenosyltransferase
CLOST_1921	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLOST_1923	COG0697	spore germination
CLOST_1928	COG2197	response regulator
CLOST_1929	COG4585	Histidine kinase
CLOST_1930	COG0835	chemotaxis
CLOST_1932	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLOST_1936	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLOST_1937	COG0564	pseudouridine synthase activity
CLOST_1938	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLOST_1939	COG0622	Phosphoesterase
CLOST_1942	COG4536	flavin adenine dinucleotide binding
CLOST_1944	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLOST_1950	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLOST_1951	COG0579	oxidoreductase
CLOST_1952	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLOST_1953	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLOST_1958	COG2267	carboxylic ester hydrolase activity
CLOST_1964	COG1028	Short-chain dehydrogenase reductase Sdr
CLOST_1967	COG1733	regulation of RNA biosynthetic process
CLOST_1972	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLOST_1973	COG5001	Diguanylate cyclase
CLOST_1973	COG3300	MHYT domain
CLOST_1977	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CLOST_1978	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CLOST_1979	COG0133	tryptophan synthase activity
CLOST_1981	COG0628	permease
CLOST_1982	COG0542	response to heat
CLOST_1983	COG2313	pseudouridylate synthase activity
CLOST_1984	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOST_1984	COG1522	sequence-specific DNA binding
CLOST_1985	COG1285	pathogenesis
CLOST_1987	COG0326	Molecular chaperone. Has ATPase activity
CLOST_1988	COG0159	tryptophan synthase activity
CLOST_1990	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLOST_1994	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLOST_1994	COG0512	Glutamine amidotransferase of anthranilate synthase
CLOST_1999	COG1959	2 iron, 2 sulfur cluster binding
CLOST_2002	COG1827	regulation of RNA biosynthetic process
CLOST_2007	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CLOST_2008	COG0352	thiamine-phosphate diphosphorylase activity
CLOST_2009	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CLOST_2010	COG0351	phosphomethylpyrimidine kinase
CLOST_2012	COG1363	Peptidase, m42
CLOST_2013	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLOST_2025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLOST_2026	COG0708	Exodeoxyribonuclease III
CLOST_2027	COG2221	Nitrite and sulphite reductase 4Fe-4S
CLOST_2031	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLOST_2033	COG1011	Hydrolase
CLOST_2037	COG2720	vancomycin resistance protein
CLOST_2039	COG0626	cystathionine gamma-synthase activity
CLOST_2043	COG0495	leucyl-tRNA aminoacylation
CLOST_2049	COG1937	Protein conserved in bacteria
CLOST_2050	COG2217	Heavy metal translocating P-type atpase
CLOST_2051	COG3437	response regulator, receiver
CLOST_2052	COG3706	GGDEF domain
CLOST_2053	COG0659	secondary active sulfate transmembrane transporter activity
CLOST_2062	COG0517	IMP dehydrogenase activity
CLOST_2063	COG0539	negative regulation of cytoplasmic translation
CLOST_2067	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLOST_2069	COG2964	Protein conserved in bacteria
CLOST_2070	COG2116	formate transmembrane transporter activity
CLOST_2072	COG0095	Lipoate-protein ligase
CLOST_2073	COG0628	permease
CLOST_2074	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CLOST_2078	COG0534	Mate efflux family protein
CLOST_2079	COG0534	Mate efflux family protein
CLOST_2082	COG3409	Peptidoglycan-binding domain 1 protein
CLOST_2082	COG0793	Belongs to the peptidase S41A family
CLOST_2083	COG0739	heme binding
CLOST_2084	COG2177	Part of the ABC transporter FtsEX involved in
CLOST_2085	COG2884	Cell division ATP-binding protein ftsE
CLOST_2086	COG2884	Cell division ATP-binding protein ftsE
CLOST_2087	COG0095	Lipoate-protein ligase
CLOST_2088	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CLOST_2089	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLOST_2093	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLOST_2094	COG1122	ATPase activity
CLOST_2095	COG1122	ATPase activity
CLOST_2100	COG3901	Regulator of nitric oxide reductase transcription
CLOST_2100	COG0348	domain, Protein
CLOST_2105	COG1067	ATP-dependent peptidase activity
CLOST_2106	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CLOST_2109	COG1368	sulfuric ester hydrolase activity
CLOST_2111	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLOST_2112	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLOST_2115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLOST_2116	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLOST_2117	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLOST_2118	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLOST_2125	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLOST_2126	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLOST_2128	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLOST_2129	COG0698	ribose 5-phosphate isomerase
CLOST_2131	COG0009	L-threonylcarbamoyladenylate synthase
CLOST_2133	COG2890	protein-(glutamine-N5) methyltransferase activity
CLOST_2134	COG3872	metal-dependent enzyme
CLOST_2135	COG1435	thymidine kinase activity
CLOST_2136	COG0254	rRNA binding
CLOST_2137	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLOST_2138	COG1494	fructose-1,6-bisphosphatase
CLOST_2139	COG1494	fructose-1,6-bisphosphatase
CLOST_2141	COG2002	toxin-antitoxin pair type II binding
CLOST_2143	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLOST_2144	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CLOST_2145	COG1774	PSP1 C-terminal conserved region
CLOST_2146	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLOST_2147	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLOST_2148	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CLOST_2150	COG0038	chloride channel
CLOST_2151	COG0840	transmembrane signaling receptor activity
CLOST_2158	COG1683	Conserved Protein
CLOST_2161	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLOST_2164	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLOST_2169	COG0203	ribosomal protein L17
CLOST_2173	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLOST_2176	COG0024	Methionine aminopeptidase
CLOST_2178	COG0201	protein transport
CLOST_2179	COG0200	Binds to the 23S rRNA
CLOST_2182	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLOST_2186	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLOST_2187	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLOST_2189	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLOST_2190	COG0255	Belongs to the universal ribosomal protein uL29 family
CLOST_2191	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLOST_2192	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLOST_2194	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLOST_2197	COG0088	Forms part of the polypeptide exit tunnel
CLOST_2198	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLOST_2201	COG0411	ABC transporter
CLOST_2203	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLOST_2210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLOST_2216	COG0250	Participates in transcription elongation, termination and antitermination
CLOST_2217	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CLOST_2222	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLOST_2226	COG0840	transmembrane signaling receptor activity
CLOST_2229	COG0252	asparaginase activity
CLOST_2229	COG5275	peptidyl-tyrosine sulfation
CLOST_2230	COG0252	asparaginase activity
CLOST_2230	COG5275	peptidyl-tyrosine sulfation
CLOST_2234	COG5275	peptidyl-tyrosine sulfation
CLOST_2234	COG0252	asparaginase activity
CLOST_2238	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CLOST_2239	COG0442	prolyl-tRNA aminoacylation
CLOST_2242	COG1045	serine acetyltransferase
CLOST_2243	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLOST_2245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLOST_2249	COG4608	Belongs to the ABC transporter superfamily
CLOST_2250	COG0444	Belongs to the ABC transporter superfamily
CLOST_2251	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLOST_2252	COG0601	transmembrane transport
CLOST_2260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLOST_2261	COG5002	protein histidine kinase activity
CLOST_2265	COG0513	Belongs to the DEAD box helicase family
CLOST_2266	COG1278	Cold shock
CLOST_2267	COG4172	Belongs to the ABC transporter superfamily
CLOST_2269	COG0601	transmembrane transport
CLOST_2271	COG0500	methyltransferase
CLOST_2275	COG0735	belongs to the Fur family
CLOST_2277	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CLOST_2281	COG3706	GGDEF domain
CLOST_2281	COG4251	negative regulation of phosphorylation
CLOST_2281	COG5001	Diguanylate cyclase
CLOST_2281	COG2203	Gaf domain
CLOST_2282	COG2203	Gaf domain
CLOST_2282	COG3706	GGDEF domain
CLOST_2282	COG5001	Diguanylate cyclase
CLOST_2282	COG4251	negative regulation of phosphorylation
CLOST_2285	COG3693	PFAM glycoside hydrolase, family 10
CLOST_2288	COG0488	(ABC) transporter
CLOST_2290	COG0488	(ABC) transporter
CLOST_2291	COG0778	Nitroreductase
CLOST_2292	COG2221	Nitrite and sulphite reductase 4Fe-4S
CLOST_2293	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLOST_2296	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CLOST_2298	COG0488	(ABC) transporter
CLOST_2300	COG0456	acetyltransferase
CLOST_2301	COG1214	PFAM Peptidase M22, glycoprotease
CLOST_2302	COG0802	atpase or kinase
CLOST_2304	COG2183	response to ionizing radiation
CLOST_2306	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLOST_2310	COG1307	EDD domain protein, DegV family
CLOST_2311	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CLOST_2313	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CLOST_2314	COG1394	ATPase activity, coupled to movement of substances
CLOST_2320	COG1269	ATP hydrolysis coupled proton transport
CLOST_2327	COG2197	response regulator
CLOST_2331	COG1516	flagellar protein fliS
CLOST_2332	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLOST_2336	COG0673	inositol 2-dehydrogenase activity
CLOST_2341	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLOST_2342	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLOST_2344	COG0463	Glycosyl transferase, family 2
CLOST_2345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLOST_2346	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CLOST_2347	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CLOST_2348	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLOST_2349	COG4786	Flagellar basal body rod
CLOST_2349	COG1256	bacterial-type flagellum assembly
CLOST_2355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLOST_2356	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLOST_2362	COG4786	Flagellar basal body rod
CLOST_2363	COG1077	Cell shape determining protein MreB Mrl
CLOST_2364	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLOST_2367	COG4193	domain, Protein
CLOST_2367	COG5263	repeat protein
CLOST_2368	COG2239	Acts as a magnesium transporter
CLOST_2370	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLOST_2371	COG3681	Belongs to the UPF0597 family
CLOST_2372	COG2964	Protein conserved in bacteria
CLOST_2374	COG1595	DNA-templated transcription, initiation
CLOST_2375	COG0784	Response regulator, receiver
CLOST_2375	COG3437	response regulator, receiver
CLOST_2376	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLOST_2377	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLOST_2378	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLOST_2379	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLOST_2381	COG2205	protein histidine kinase activity
CLOST_2381	COG4191	Histidine kinase
CLOST_2381	COG0745	RESPONSE REGULATOR receiver
CLOST_2383	COG5001	Diguanylate cyclase
CLOST_2383	COG4251	negative regulation of phosphorylation
CLOST_2383	COG3706	GGDEF domain
CLOST_2383	COG2203	Gaf domain
CLOST_2386	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLOST_2387	COG0628	permease
CLOST_2388	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLOST_2393	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLOST_2394	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CLOST_2395	COG0083	homoserine kinase activity
CLOST_2398	COG1268	BioY protein
CLOST_2399	COG0281	malic enzyme
CLOST_2401	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLOST_2404	COG0789	Transcriptional regulator
CLOST_2409	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CLOST_2410	COG1879	ABC-type sugar transport system periplasmic component
CLOST_2411	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLOST_2412	COG1129	ABC transporter
CLOST_2414	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLOST_2418	COG3706	GGDEF domain
CLOST_2424	COG0017	Asparaginyl-tRNA synthetase
CLOST_2425	COG2897	thiosulfate sulfurtransferase activity
CLOST_2427	COG2340	Cysteine-rich secretory protein family
CLOST_2434	COG0784	Response regulator, receiver
CLOST_2434	COG3437	response regulator, receiver
CLOST_2435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLOST_2435	COG4191	Histidine kinase
CLOST_2437	COG0840	transmembrane signaling receptor activity
CLOST_2440	COG1126	abc transporter atp-binding protein
CLOST_2455	COG2824	Alkylphosphonate utilization operon protein PhnA
CLOST_2458	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLOST_2460	COG0726	polysaccharide deacetylase
CLOST_2462	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOST_2463	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLOST_2464	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLOST_2465	COG1120	ATPase activity
CLOST_2468	COG1032	radical SAM domain protein
CLOST_2473	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CLOST_2475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CLOST_2478	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLOST_2484	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLOST_2485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLOST_2489	COG1131	(ABC) transporter
CLOST_2490	COG0789	Transcriptional regulator
CLOST_2493	COG3620	sequence-specific DNA binding
CLOST_2495	COG0577	efflux transmembrane transporter activity
CLOST_2495	COG1136	(ABC) transporter
CLOST_2497	COG2814	Major facilitator Superfamily
CLOST_2498	COG1309	transcriptional regulator
CLOST_2502	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CLOST_2507	COG0514	ATP-dependent DNA helicase (RecQ)
CLOST_2509	COG3177	Filamentation induced by cAMP protein fic
CLOST_2528	COG2003	Belongs to the UPF0758 family
CLOST_2538	COG1846	Transcriptional regulator
CLOST_2539	COG0384	phenazine biosynthesis protein PhzF
CLOST_2546	COG1475	DNA binding
CLOST_2547	COG1192	Involved in chromosome partitioning
CLOST_2548	COG1136	(ABC) transporter
CLOST_2549	COG0577	efflux transmembrane transporter activity
CLOST_2549	COG1136	(ABC) transporter
CLOST_2550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLOST_2551	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLOST_2552	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CLOST_2556	COG5002	protein histidine kinase activity
CLOST_2557	COG0745	RESPONSE REGULATOR receiver
CLOST_2560	COG2116	formate transmembrane transporter activity
CLOST_2561	COG2200	EAL domain
CLOST_2564	COG0305	Participates in initiation and elongation during chromosome replication
CLOST_2566	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CLOST_2568	COG0431	NADPH-dependent FMN reductase
CLOST_2569	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLOST_2570	COG0629	single-stranded DNA binding
CLOST_2572	COG4481	Protein conserved in bacteria
CLOST_2578	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLOST_2579	COG1475	DNA binding
CLOST_2580	COG0357	Ribosomal RNA small subunit methyltransferase G
CLOST_2582	COG1725	Transcriptional regulator
CLOST_2583	COG1131	(ABC) transporter
CLOST_2586	COG1847	R3H domain protein
CLOST_2587	COG0706	membrane insertase activity
CLOST_2590	COG0230	Belongs to the bacterial ribosomal protein bL34 family