locus-tag	class	description
DB34_00010	COG0004	ammonium transporteR
DB34_00030	COG4974	Belongs to the 'phage' integrase family
DB34_00055	COG0494	nUDIX hydrolase
DB34_00075	COG2967	ApaG domain
DB34_00080	COG0302	gtp cyclohydrolase
DB34_00090	COG0521	Mo-molybdopterin cofactor biosynthetic process
DB34_00120	COG1566	PFAM secretion protein HlyD family protein
DB34_00155	COG3293	Transposase
DB34_00160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DB34_00165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DB34_00165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DB34_00170	COG0307	riboflavin synthase, alpha
DB34_00180	COG2857	Cytochrome c1
DB34_00180	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DB34_00185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DB34_00185	COG2857	Cytochrome c1
DB34_00190	COG0723	plastoquinol--plastocyanin reductase activity
DB34_00210	COG2252	PERMEase
DB34_00285	COG2963	transposase activity
DB34_00310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DB34_00315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DB34_00320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DB34_00325	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DB34_00335	COG3750	Belongs to the UPF0335 family
DB34_00340	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DB34_00355	COG2001	Belongs to the MraZ family
DB34_00360	COG0275	rRNA processing
DB34_00375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DB34_00385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DB34_00390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DB34_00400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DB34_00405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DB34_00410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DB34_00415	COG1181	Belongs to the D-alanine--D-alanine ligase family
DB34_00420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DB34_00425	COG0849	cell division
DB34_00440	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DB34_00445	COG0497	DNA recombination
DB34_00450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DB34_00455	COG0574	Belongs to the PEP-utilizing enzyme family
DB34_00455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DB34_00460	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DB34_00480	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DB34_00495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DB34_00500	COG1335	isochorismatase
DB34_00520	COG2132	Multicopper oxidase
DB34_00530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DB34_00540	COG0028	Belongs to the TPP enzyme family
DB34_00545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DB34_00550	COG0560	Phosphoserine phosphatase
DB34_00565	COG0513	Belongs to the DEAD box helicase family
DB34_00580	COG2988	succinylglutamate desuccinylase activity
DB34_00585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DB34_00590	COG0531	amino acid
DB34_00595	COG0113	porphobilinogen synthase activity
DB34_00600	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DB34_00605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DB34_00610	COG1381	Involved in DNA repair and RecF pathway recombination
DB34_00615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DB34_00620	COG0052	Belongs to the universal ribosomal protein uS2 family
DB34_00650	COG0587	DNA-directed DNA polymerase activity
DB34_00660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DB34_00665	COG0251	oxidation-reduction process
DB34_00690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DB34_00710	COG3161	chorismate lyase activity
DB34_00715	COG1032	radical SAM domain protein
DB34_00720	COG0105	UTP biosynthetic process
DB34_00725	COG0488	(ABC) transporter
DB34_00735	COG0745	RESPONSE REGULATOR receiver
DB34_00750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DB34_00755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DB34_00775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DB34_00790	COG0328	RNA-DNA hybrid ribonuclease activity
DB34_00795	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DB34_00800	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DB34_00850	COG1530	ribonuclease E activity
DB34_00855	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DB34_00860	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DB34_00865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DB34_00870	COG0424	maF-like protein
DB34_00880	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DB34_00980	COG0277	FAD linked oxidase domain protein
DB34_00995	COG2308	Evidence 4 Homologs of previously reported genes of
DB34_01025	COG1309	transcriptional regulator
DB34_01030	COG1252	NADH dehydrogenase
DB34_01035	COG1012	belongs to the aldehyde dehydrogenase family
DB34_01050	COG2814	Major facilitator Superfamily
DB34_01060	COG0431	NADPH-dependent FMN reductase
DB34_01070	COG0583	DNA-binding transcription factor activity
DB34_01105	COG0697	spore germination
DB34_01110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DB34_01115	COG1984	allophanate hydrolase subunit 2
DB34_01125	COG4221	oxidoreductase activity
DB34_01135	COG0439	Biotin carboxylase
DB34_01160	COG0300	oxidoreductase activity
DB34_01170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DB34_01175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DB34_01180	COG0297	glycogen (starch) synthase activity
DB34_01195	COG1028	Short-chain dehydrogenase reductase Sdr
DB34_01200	COG0028	Belongs to the TPP enzyme family
DB34_01210	COG1999	signal sequence binding
DB34_01265	COG0583	DNA-binding transcription factor activity
DB34_01295	COG4232	protein-disulfide reductase activity
DB34_01305	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DB34_01310	COG0805	protein transport
DB34_01315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DB34_01320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DB34_01325	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DB34_01335	COG0018	arginyl-trna synthetase
DB34_01340	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DB34_01345	COG0316	Belongs to the HesB IscA family
DB34_01350	COG0708	Exodeoxyribonuclease III
DB34_01355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DB34_01375	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DB34_01380	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DB34_01390	COG0535	radical SAM domain protein
DB34_01400	COG0740	serine-type endopeptidase activity
DB34_01410	COG0436	Aminotransferase
DB34_01420	COG1494	fructose-1,6-bisphosphatase
DB34_01430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DB34_01435	COG0564	pseudouridine synthase activity
DB34_01440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DB34_01445	COG1120	ATPase activity
DB34_01450	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DB34_01460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DB34_01465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DB34_01465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DB34_01485	COG1294	oxidase, subunit
DB34_01490	COG1271	oxidase subunit
DB34_01505	COG1113	amino acid transport
DB34_01515	COG4993	Dehydrogenase
DB34_01525	COG3293	Transposase
DB34_01530	COG1942	4-Oxalocrotonate Tautomerase
DB34_01540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DB34_01555	COG0493	'glutamate synthase
DB34_01575	COG1953	Uracil, thiamine, allantoin
DB34_01595	COG0284	orotidine-5'-phosphate decarboxylase activity
DB34_01605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DB34_01615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DB34_01620	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DB34_01630	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DB34_01650	COG3145	DNA-N1-methyladenine dioxygenase activity
DB34_01660	COG3620	sequence-specific DNA binding
DB34_01670	COG2011	ABC-type metal ion transport system permease component
DB34_01675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DB34_01685	COG0277	FAD linked oxidase domain protein
DB34_01690	COG1648	precorrin-2 dehydrogenase activity
DB34_01690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DB34_01700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DB34_01735	COG2814	Major facilitator Superfamily
DB34_01745	COG3128	pkhd-type hydroxylase
DB34_01760	COG4774	siderophore transport
DB34_01770	COG3293	Transposase
DB34_01780	COG0848	biopolymer transport protein
DB34_01800	COG1301	dicarboxylic acid transport
DB34_01835	COG2814	Major facilitator Superfamily
DB34_01845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DB34_01850	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DB34_01865	COG0778	Nitroreductase
DB34_01870	COG1492	cobalamin metabolic process
DB34_01885	COG1797	cobyrinic acid a,c-diamide synthase activity
DB34_01910	COG1289	transmembrane transporter activity
DB34_01915	COG1584	GPR1 FUN34 yaaH family protein
DB34_01920	COG1024	Enoyl-CoA hydratase
DB34_01925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DB34_01930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DB34_01935	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DB34_01945	COG0735	belongs to the Fur family
DB34_01960	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DB34_01980	COG0519	Catalyzes the synthesis of GMP from XMP
DB34_01980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DB34_01995	COG2814	Major facilitator Superfamily
DB34_02000	COG0739	heme binding
DB34_02000	COG0741	lytic transglycosylase activity
DB34_02000	COG1196	nuclear chromosome segregation
DB34_02020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DB34_02060	COG1742	UPF0060 membrane protein
DB34_02075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DB34_02090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DB34_02095	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DB34_02105	COG0363	glucosamine-6-phosphate deaminase activity
DB34_02110	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DB34_02115	COG3265	gluconokinase activity
DB34_02150	COG3158	transport of potassium into the cell
DB34_02155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DB34_02175	COG0410	ABC transporter
DB34_02180	COG0411	ABC transporter
DB34_02190	COG0559	Belongs to the binding-protein-dependent transport system permease family
DB34_02200	COG2205	protein histidine kinase activity
DB34_02200	COG2198	Histidine kinase
DB34_02200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB34_02200	COG0784	Response regulator, receiver
DB34_02205	COG0745	RESPONSE REGULATOR receiver
DB34_02245	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DB34_02250	COG0830	nickel cation binding
DB34_02255	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DB34_02260	COG0804	urea catabolic process
DB34_02265	COG0832	Belongs to the urease beta subunit family
DB34_02270	COG0831	urea catabolic process
DB34_02275	COG0829	nickel cation binding
DB34_02280	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DB34_02285	COG3961	Belongs to the TPP enzyme family
DB34_02310	COG1393	Belongs to the ArsC family
DB34_02320	COG2818	Glycosylase
DB34_02325	COG0640	Transcriptional regulator
DB34_02330	COG0450	alkyl hydroperoxide reductase
DB34_02380	COG0583	DNA-binding transcription factor activity
DB34_02390	COG2271	Major facilitator Superfamily
DB34_02395	COG3473	Maleate cis-trans isomerase
DB34_02400	COG0596	Alpha beta hydrolase
DB34_02405	COG1335	isochorismatase
DB34_02410	COG2309	aminopeptidase activity
DB34_02415	COG2010	Cytochrome c
DB34_02415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DB34_02420	COG2080	2 iron, 2 sulfur cluster binding
DB34_02425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DB34_02430	COG1846	Transcriptional regulator
DB34_02475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DB34_02485	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DB34_02505	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DB34_02505	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DB34_02510	COG0509	glycine decarboxylation via glycine cleavage system
DB34_02515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DB34_02520	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DB34_02525	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DB34_02535	COG0583	DNA-binding transcription factor activity
DB34_02545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DB34_02550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DB34_02555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DB34_02570	COG1185	polyribonucleotide nucleotidyltransferase activity
DB34_02575	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DB34_02580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DB34_02585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DB34_02590	COG1127	ABC transporter
DB34_02595	COG3008	intermembrane lipid transfer
DB34_02595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DB34_02640	COG1410	methionine synthase
DB34_02640	COG0646	methionine synthase
DB34_02655	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DB34_02665	COG3008	intermembrane lipid transfer
DB34_02670	COG2995	paraquat-inducible protein a
DB34_02680	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DB34_02685	COG0463	Glycosyl transferase, family 2
DB34_02690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DB34_02695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DB34_02700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DB34_02705	COG0356	it plays a direct role in the translocation of protons across the membrane
DB34_02715	COG0552	protein localization to endoplasmic reticulum
DB34_02720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DB34_02725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DB34_02730	COG0346	lactoylglutathione lyase activity
DB34_02740	COG0513	Belongs to the DEAD box helicase family
DB34_02755	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DB34_02760	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DB34_02775	COG0704	Plays a role in the regulation of phosphate uptake
DB34_02780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DB34_02790	COG0573	inorganic phosphate transmembrane transporter activity
DB34_02795	COG0129	dihydroxy-acid dehydratase activity
DB34_02830	COG0489	protein tyrosine kinase activity
DB34_02845	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DB34_02855	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DB34_02855	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DB34_02870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DB34_02875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DB34_02880	COG1522	sequence-specific DNA binding
DB34_02885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DB34_02890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DB34_02905	COG0779	Required for maturation of 30S ribosomal subunits
DB34_02915	COG0542	response to heat
DB34_02930	COG0765	amino acid transport
DB34_02935	COG1126	abc transporter atp-binding protein
DB34_02950	COG4133	protoheme IX ABC transporter activity
DB34_02970	COG1295	ribonuclease BN
DB34_02980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DB34_02985	COG0511	ligase activity, forming carbon-carbon bonds
DB34_02990	COG0439	Biotin carboxylase
DB34_02995	COG2814	Major facilitator Superfamily
DB34_03000	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DB34_03045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DB34_03055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DB34_03060	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DB34_03065	COG0154	amidase activity
DB34_03070	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DB34_03225	COG5265	(ABC) transporter
DB34_03230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DB34_03235	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DB34_03265	COG0495	leucyl-tRNA aminoacylation
DB34_03340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DB34_03350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DB34_03355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DB34_03360	COG0590	tRNA wobble adenosine to inosine editing
DB34_03365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DB34_03370	COG1187	pseudouridine synthase activity
DB34_03375	COG0742	ribosomal rna small subunit methyltransferase
DB34_03380	COG0629	single-stranded DNA binding
DB34_03390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DB34_03420	COG0438	transferase activity, transferring glycosyl groups
DB34_03430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DB34_03435	COG0312	modulator of DNA gyrase
DB34_03440	COG0406	alpha-ribazole phosphatase activity
DB34_03460	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DB34_03465	COG1091	dTDP-4-dehydrorhamnose reductase activity
DB34_03475	COG1674	ftsk spoiiie
DB34_03480	COG0564	pseudouridine synthase activity
DB34_03485	COG3293	Transposase
DB34_03505	COG0482	sulfurtransferase activity
DB34_03515	COG1104	cysteine desulfurase activity
DB34_03525	COG2945	thiolester hydrolase activity
DB34_03535	COG0215	cysteine-tRNA ligase activity
DB34_03545	COG0285	dihydrofolate synthase activity
DB34_03550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DB34_03565	COG2887	Belongs to the helicase family. UvrD subfamily
DB34_03570	COG0802	atpase or kinase
DB34_03575	COG0745	RESPONSE REGULATOR receiver
DB34_03580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DB34_03590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DB34_03595	COG0037	tRNA processing
DB34_03605	COG2885	chlorophyll binding
DB34_03610	COG0823	Involved in the tonB-independent uptake of proteins
DB34_03620	COG0848	biopolymer transport protein
DB34_03630	COG0824	Thioesterase
DB34_03635	COG2255	four-way junction helicase activity
DB34_03640	COG0632	four-way junction helicase activity
DB34_03645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DB34_03650	COG0217	transcriptional regulatory protein
DB34_03655	COG0653	protein targeting
DB34_03660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DB34_03665	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DB34_03675	COG0668	transmembrane transport
DB34_03730	COG3293	Transposase
DB34_03740	COG0776	regulation of translation
DB34_03760	COG0463	Glycosyl transferase, family 2
DB34_03760	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DB34_03775	COG0131	Imidazoleglycerol-phosphate dehydratase
DB34_03780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DB34_03785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DB34_03790	COG0107	imidazoleglycerol-phosphate synthase activity
DB34_03795	COG0140	phosphoribosyl-ATP diphosphatase activity
DB34_03805	COG0778	Nitroreductase
DB34_03835	COG1475	DNA binding
DB34_03840	COG1192	Involved in chromosome partitioning
DB34_03845	COG0357	Ribosomal RNA small subunit methyltransferase G
DB34_03850	COG0445	tRNA wobble uridine modification
DB34_03855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DB34_03860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DB34_03880	COG1611	Belongs to the LOG family
DB34_03885	COG2814	Major facilitator Superfamily
DB34_03900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DB34_03905	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DB34_04000	COG0582	viral genome integration into host DNA
DB34_04005	COG1671	Belongs to the UPF0178 family
DB34_04015	COG2814	Major facilitator Superfamily
DB34_04025	COG2835	tetraacyldisaccharide 4'-kinase activity
DB34_04030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DB34_04065	COG0778	Nitroreductase
DB34_04075	COG0456	acetyltransferase
DB34_04085	COG1570	exodeoxyribonuclease VII activity
DB34_04130	COG1012	belongs to the aldehyde dehydrogenase family
DB34_04140	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DB34_04145	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DB34_04150	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DB34_04155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DB34_04165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DB34_04175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DB34_04190	COG0126	phosphoglycerate kinase activity
DB34_04200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DB34_04210	COG0156	8-amino-7-oxononanoate synthase activity
DB34_04215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DB34_04220	COG0405	Gamma-glutamyltransferase
DB34_04240	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DB34_04250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DB34_04270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DB34_04275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DB34_04285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DB34_04295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DB34_04300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DB34_04310	COG0539	negative regulation of cytoplasmic translation
DB34_04325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DB34_04330	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DB34_04335	COG1420	regulation of RNA biosynthetic process
DB34_04340	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DB34_04375	COG0772	Belongs to the SEDS family
DB34_04380	COG0768	penicillin binding
DB34_04400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DB34_04405	COG1612	heme a metabolic process
DB34_04415	COG2814	Major facilitator Superfamily
DB34_04425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DB34_04430	COG1289	transmembrane transporter activity
DB34_04440	COG1573	uracil-dna glycosylase
DB34_04460	COG0670	Belongs to the BI1 family
DB34_04485	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DB34_04500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DB34_04515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DB34_04535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DB34_04555	COG1028	Short-chain dehydrogenase reductase Sdr
DB34_04560	COG0586	Pfam SNARE associated Golgi protein
DB34_04575	COG0281	malic enzyme
DB34_04605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DB34_04610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DB34_04615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DB34_04620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DB34_04625	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DB34_04630	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DB34_04635	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DB34_04640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DB34_04655	COG1113	amino acid transport
DB34_04660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DB34_04665	COG4208	sulfate ABC transporter
DB34_04685	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DB34_04690	COG2207	Transcriptional regulator
DB34_04695	COG4303	Ethanolamine ammonia lyase large subunit
DB34_04700	COG4302	ethanolamine ammonia-lyase activity
DB34_04710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DB34_04720	COG1538	Outer membrane efflux protein
DB34_04725	COG1278	Cold shock
DB34_04790	COG2983	Belongs to the UPF0260 family
DB34_04805	COG3842	ATPase activity
DB34_04830	COG1566	PFAM secretion protein HlyD family protein
DB34_04850	COG1657	PFAM Prenyltransferase squalene oxidase
DB34_04855	COG1233	COG1233 Phytoene dehydrogenase and related
DB34_04860	COG1562	ergosterol biosynthetic process
DB34_04865	COG1562	ergosterol biosynthetic process
DB34_04875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DB34_04885	COG0287	Prephenate dehydrogenase
DB34_04900	COG0450	alkyl hydroperoxide reductase
DB34_04905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DB34_04925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DB34_04935	COG0488	(ABC) transporter
DB34_04955	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DB34_04965	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DB34_04970	COG0343	queuine tRNA-ribosyltransferase activity
DB34_04975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DB34_04985	COG1881	PFAM PEBP family protein
DB34_05010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DB34_05025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DB34_05055	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DB34_05060	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DB34_05075	COG0667	Aldo Keto reductase
DB34_05085	COG0556	nucleotide-excision repair
DB34_05095	COG0612	Peptidase, M16
DB34_05140	COG3547	Transposase (IS116 IS110 IS902 family)
DB34_05160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DB34_05175	COG0167	dihydroorotate dehydrogenase activity
DB34_05185	COG1051	belongs to the nudix hydrolase family
DB34_05190	COG1692	metallophosphoesterase
DB34_05195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DB34_05220	COG0352	thiamine-phosphate diphosphorylase activity
DB34_05245	COG1509	lysine 2,3-aminomutase activity
DB34_05255	COG0024	Methionine aminopeptidase
DB34_05260	COG1686	Belongs to the peptidase S11 family
DB34_05265	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DB34_05280	COG2326	polyphosphate kinase activity
DB34_05285	COG1678	Uncharacterized ACR, COG1678
DB34_05290	COG1660	Displays ATPase and GTPase activities
DB34_05300	COG2205	protein histidine kinase activity
DB34_05305	COG0745	RESPONSE REGULATOR receiver
DB34_05310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DB34_05315	COG0443	Heat shock 70 kDa protein
DB34_05320	COG0484	heat shock protein binding
DB34_05325	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DB34_05330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DB34_05335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DB34_05340	COG0138	bifunctional purine biosynthesis protein purh
DB34_05355	COG0697	spore germination
DB34_05365	COG0752	glycyl-tRNA synthetase alpha subunit
DB34_05375	COG1396	sequence-specific DNA binding
DB34_05385	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DB34_05405	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DB34_05415	COG0598	Magnesium transport protein CorA
DB34_05420	COG0133	tryptophan synthase activity
DB34_05425	COG0159	tryptophan synthase activity
DB34_05430	COG1053	succinate dehydrogenase
DB34_05430	COG0431	NADPH-dependent FMN reductase
DB34_05430	COG3976	FMN-binding domain protein
DB34_05440	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DB34_05445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DB34_05450	COG0745	RESPONSE REGULATOR receiver
DB34_05460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DB34_05485	COG1253	flavin adenine dinucleotide binding
DB34_05490	COG0604	alcohol dehydrogenase
DB34_05500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DB34_05515	COG1028	Short-chain dehydrogenase reductase Sdr
DB34_05520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DB34_05525	COG3956	TIGRFAM MazG family protein
DB34_05535	COG0326	Molecular chaperone. Has ATPase activity
DB34_05730	COG2079	MmgE PrpD family protein
DB34_05735	COG0372	Belongs to the citrate synthase family
DB34_05740	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DB34_05745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DB34_05750	COG2814	Major facilitator Superfamily
DB34_05755	COG2319	Wd-40 repeat
DB34_05765	COG2309	aminopeptidase activity
DB34_05780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DB34_05790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DB34_05795	COG0193	aminoacyl-tRNA hydrolase activity
DB34_05800	COG0012	GTP binding
DB34_05805	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DB34_05810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DB34_05815	COG0799	negative regulation of ribosome biogenesis
DB34_05820	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DB34_05855	COG0247	lactate metabolic process
DB34_05860	COG1139	Iron-sulfur cluster binding protein
DB34_05870	COG0697	spore germination
DB34_05875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DB34_05880	COG0717	Belongs to the dCTP deaminase family
DB34_05895	COG3394	polysaccharide catabolic process
DB34_05925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DB34_05930	COG1253	flavin adenine dinucleotide binding
DB34_05935	COG0741	lytic transglycosylase activity
DB34_05940	COG1573	uracil-dna glycosylase
DB34_05950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DB34_05990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DB34_06030	COG1028	Short-chain dehydrogenase reductase Sdr
DB34_06040	COG0025	NhaP-type Na H and K H
DB34_06050	COG4771	TonB-dependent receptor
DB34_06060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DB34_06065	COG1120	ATPase activity
DB34_06070	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DB34_06075	COG2971	BadF BadG BcrA BcrD
DB34_06080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DB34_06095	COG0415	Belongs to the DNA photolyase family
DB34_06100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DB34_06125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DB34_06200	COG1012	belongs to the aldehyde dehydrogenase family
DB34_06275	COG3293	Transposase
DB34_06505	COG2963	transposase activity
DB34_06515	COG4372	Transposase
DB34_06525	COG2963	transposase activity
DB34_06535	COG4372	Transposase
DB34_06645	COG4774	siderophore transport
DB34_06965	COG1959	2 iron, 2 sulfur cluster binding
DB34_06970	COG4221	oxidoreductase activity
DB34_06975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DB34_06990	COG1607	acyl-coa hydrolase
DB34_07065	COG0306	phosphate transporter
DB34_07075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DB34_07080	COG0022	dehydrogenase e1 component
DB34_07090	COG0071	Belongs to the small heat shock protein (HSP20) family
DB34_07105	COG1252	NADH dehydrogenase
DB34_07115	COG0523	cobalamin synthesis protein
DB34_07125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DB34_07135	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DB34_07140	COG0596	Alpha beta hydrolase
DB34_07155	COG1297	OPT oligopeptide transporter protein
DB34_07185	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DB34_07200	COG0469	pyruvate kinase activity
DB34_07230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DB34_07240	COG0492	ferredoxin-NADP+ reductase activity
DB34_07245	COG0538	isocitrate dehydrogenase activity
DB34_07285	COG4993	Dehydrogenase
DB34_07300	COG0481	GTPase activity
DB34_07305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DB34_07310	COG2813	Specifically methylates the guanine in position
DB34_07310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DB34_07315	COG0513	Belongs to the DEAD box helicase family
DB34_07340	COG1758	RNA polymerase activity
DB34_07345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DB34_07350	COG0736	holo-[acyl-carrier-protein] synthase activity
DB34_07355	COG0681	Belongs to the peptidase S26 family
DB34_07360	COG0571	ribonuclease III activity
DB34_07365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DB34_07370	COG0528	UMP kinase activity
DB34_07375	COG0233	cytoplasmic translational termination
DB34_07380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DB34_07390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DB34_07395	COG0750	zinc metalloprotease
DB34_07410	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DB34_07415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DB34_07420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DB34_07425	COG3494	Protein of unknown function (DUF1009)
DB34_07430	COG0346	lactoylglutathione lyase activity
DB34_07440	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DB34_07445	COG0594	ribonuclease P activity
DB34_07450	COG0706	membrane insertase activity
DB34_07455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DB34_07460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DB34_07465	COG2171	N-acyltransferase activity
DB34_07470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DB34_07480	COG0101	tRNA pseudouridine synthase activity
DB34_07485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DB34_07490	COG0242	peptide deformylase activity
DB34_07505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DB34_07520	COG1137	ATPase activity
DB34_07535	COG0517	IMP dehydrogenase activity
DB34_07535	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DB34_07545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DB34_07560	COG0194	GDP metabolic process
DB34_07565	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DB34_07565	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DB34_07570	COG2942	2-epimerase
DB34_07575	COG0305	Participates in initiation and elongation during chromosome replication
DB34_07585	COG3264	Mechanosensitive ion channel
DB34_07585	COG1196	nuclear chromosome segregation
DB34_07590	COG1127	ABC transporter
DB34_07595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DB34_07635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DB34_07650	COG1113	amino acid transport
DB34_07660	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DB34_07660	COG0506	proline dehydrogenase activity
DB34_07660	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DB34_07675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DB34_07705	COG2096	Adenosyltransferase
DB34_07730	COG0009	L-threonylcarbamoyladenylate synthase
DB34_07740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DB34_07750	COG0656	L-ascorbic acid biosynthetic process
DB34_07760	COG1643	Atp-dependent helicase
DB34_07770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DB34_07780	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DB34_07785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DB34_07805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DB34_07810	COG0235	Class ii aldolase
DB34_07815	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DB34_07820	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DB34_07825	COG0196	riboflavin kinase activity
DB34_07830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DB34_07835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DB34_07845	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DB34_07855	COG5006	permease, DMT superfamily
DB34_07860	COG0187	DNA topoisomerase II activity
DB34_07875	COG1959	2 iron, 2 sulfur cluster binding
DB34_07880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DB34_07885	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DB34_07885	COG2885	chlorophyll binding
DB34_07895	COG0793	Belongs to the peptidase S41A family
DB34_07900	COG0557	exoribonuclease II activity
DB34_07905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DB34_07910	COG0758	DNA mediated transformation
DB34_07915	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DB34_07920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DB34_07925	COG0540	Belongs to the ATCase OTCase family
DB34_07930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DB34_07935	COG0658	competence protein
DB34_07935	COG2333	competence protein COMEC
DB34_07940	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DB34_07945	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DB34_07955	COG0508	dehydrogenase complex catalyzes the overall conversion of
DB34_07975	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DB34_07990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DB34_08025	COG3260	NADH ubiquinone oxidoreductase 20
DB34_08030	COG1183	phosphatidylcholine synthase activity
DB34_08035	COG0688	phosphatidylethanolamine metabolic process
DB34_08040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DB34_08050	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DB34_08050	COG2885	chlorophyll binding
DB34_08055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DB34_08065	COG4974	Belongs to the 'phage' integrase family
DB34_08070	COG0825	malonyl-CoA metabolic process
DB34_08075	COG1546	Belongs to the CinA family
DB34_08075	COG1058	Belongs to the CinA family
DB34_08080	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DB34_08095	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DB34_08100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DB34_08105	COG0181	hydroxymethylbilane synthase activity
DB34_08115	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DB34_08120	COG0406	alpha-ribazole phosphatase activity
DB34_08130	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DB34_08150	COG0408	coproporphyrinogen oxidase activity
DB34_08155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DB34_08155	COG2857	Cytochrome c1
DB34_08160	COG2857	Cytochrome c1
DB34_08160	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DB34_08165	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DB34_08175	COG3293	Transposase
DB34_08195	COG0778	Nitroreductase
DB34_08255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DB34_08260	COG1902	pentaerythritol trinitrate reductase activity
DB34_08265	COG0640	Transcriptional regulator
DB34_08275	COG3591	Belongs to the peptidase S1B family
DB34_08280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DB34_08290	COG0019	diaminopimelate decarboxylase activity
DB34_08295	COG0165	Argininosuccinate lyase
DB34_08310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DB34_08315	COG0237	dephospho-CoA kinase activity
DB34_08320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DB34_08340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DB34_08350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DB34_08355	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DB34_08365	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DB34_08370	COG0248	Ppx GppA phosphatase
DB34_08385	COG1121	(ABC) transporter
DB34_08410	COG1289	transmembrane transporter activity
DB34_08415	COG1289	transmembrane transporter activity
DB34_08435	COG3088	subunit of a heme lyase
DB34_08440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DB34_08445	COG1138	Cytochrome C-type biogenesis protein
DB34_08450	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DB34_08455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DB34_08490	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DB34_08520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DB34_08535	COG3293	Transposase
DB34_08545	COG3293	Transposase
DB34_08550	COG0477	Major facilitator Superfamily
DB34_08585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DB34_08590	COG0081	regulation of translation
DB34_08595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DB34_08600	COG0222	ribosome binding
DB34_08605	COG0085	RNA polymerase activity
DB34_08610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DB34_08615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DB34_08620	COG0049	tRNA binding
DB34_08625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DB34_08630	COG0051	transcription antitermination factor activity, RNA binding
DB34_08635	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DB34_08640	COG0088	Forms part of the polypeptide exit tunnel
DB34_08645	COG0089	rRNA binding
DB34_08650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DB34_08655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DB34_08660	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DB34_08665	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DB34_08670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DB34_08675	COG0255	Belongs to the universal ribosomal protein uL29 family
DB34_08680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DB34_08685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DB34_08690	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DB34_08695	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DB34_08700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DB34_08705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DB34_08710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DB34_08715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DB34_08720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DB34_08725	COG1841	ribosomal large subunit assembly
DB34_08730	COG0200	Binds to the 23S rRNA
DB34_08740	COG0563	adenylate kinase activity
DB34_08745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DB34_08750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DB34_08755	COG0202	RNA polymerase activity
DB34_08760	COG0203	ribosomal protein L17
DB34_08770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DB34_08775	COG1116	anion transmembrane transporter activity
DB34_08790	COG1538	Outer membrane efflux protein
DB34_08800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DB34_08805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DB34_08810	COG0477	Major facilitator Superfamily
DB34_08815	COG3237	CsbD-like
DB34_08820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DB34_08825	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DB34_08850	COG0714	Associated with various cellular activities
DB34_08860	COG0617	tRNA 3'-terminal CCA addition
DB34_08865	COG1132	(ABC) transporter
DB34_08875	COG2814	Major facilitator Superfamily
DB34_08880	COG1051	belongs to the nudix hydrolase family
DB34_08890	COG0793	Belongs to the peptidase S41A family
DB34_08900	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DB34_08905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DB34_08910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DB34_08915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DB34_08920	COG0505	Belongs to the CarA family
DB34_08930	COG0358	DNA primase activity
DB34_08935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DB34_08945	COG0360	Binds together with S18 to 16S ribosomal RNA
DB34_08950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DB34_08955	COG0359	binds to the 23S rRNA
DB34_08960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DB34_08965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DB34_08975	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DB34_08995	COG1132	(ABC) transporter
DB34_09000	COG1802	Transcriptional regulator
DB34_09005	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DB34_09015	COG0850	regulation of cytokinetic process
DB34_09025	COG2081	HI0933 family
DB34_09030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DB34_09040	COG0457	Tetratricopeptide repeat
DB34_09040	COG0859	PFAM glycosyl transferase family 9
DB34_09045	COG1329	Transcriptional regulator
DB34_09050	COG3781	membrane
DB34_09055	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DB34_09070	COG2884	Cell division ATP-binding protein ftsE
DB34_09095	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DB34_09100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DB34_09120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DB34_09120	COG2010	Cytochrome c
DB34_09125	COG0246	Mannitol dehydrogenase
DB34_09130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DB34_09135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DB34_09140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DB34_09145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DB34_09145	COG0072	phenylalanine-tRNA ligase activity
DB34_09155	COG0747	negative chemotaxis
DB34_09175	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DB34_09190	COG0473	3-isopropylmalate dehydrogenase activity
DB34_09195	COG0006	proline dipeptidase activity
DB34_09200	COG2264	protein methyltransferase activity
DB34_09215	COG2003	Belongs to the UPF0758 family
DB34_09220	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DB34_09245	COG0071	Belongs to the small heat shock protein (HSP20) family
DB34_09250	COG0254	rRNA binding
DB34_09255	COG1970	mechanosensitive ion channel activity
DB34_09265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DB34_09270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DB34_09285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DB34_09285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DB34_09290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DB34_09300	COG0142	geranyltranstransferase activity
DB34_09305	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DB34_09310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DB34_09325	COG2062	phosphohistidine phosphatase, SixA
DB34_09330	COG1605	Chorismate mutase
DB34_09330	COG0287	Prephenate dehydrogenase
DB34_09355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DB34_09365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DB34_09375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DB34_09385	COG0729	surface antigen
DB34_09405	COG0322	excinuclease ABC activity
DB34_09420	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DB34_09425	COG0314	molybdopterin synthase activity
DB34_09430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DB34_09435	COG0156	8-amino-7-oxononanoate synthase activity
DB34_09445	COG4106	trans-aconitate 2-methyltransferase activity
DB34_09445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DB34_09450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DB34_09455	COG0303	'Molybdopterin
DB34_09460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DB34_09470	COG0148	phosphopyruvate hydratase activity
DB34_09490	COG2022	thiamine diphosphate biosynthetic process
DB34_09505	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DB34_09510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DB34_09525	COG0076	glutamate decarboxylase activity
DB34_09540	COG0484	heat shock protein binding
DB34_09545	COG0271	Belongs to the BolA IbaG family
DB34_09555	COG0321	lipoyl(octanoyl) transferase activity
DB34_09575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DB34_09580	COG2226	methyltransferase
DB34_09605	COG2706	6-phosphogluconolactonase activity
DB34_09610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DB34_09615	COG0527	aspartate kinase activity
DB34_09620	COG2070	2-Nitropropane dioxygenase
DB34_09630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DB34_09635	COG0124	histidyl-tRNA synthetase
DB34_09640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DB34_09650	COG2890	protein-(glutamine-N5) methyltransferase activity
DB34_09670	COG1968	undecaprenyl-diphosphatase activity
DB34_09675	COG0531	amino acid
DB34_09685	COG0586	Pfam SNARE associated Golgi protein
DB34_09690	COG2951	lytic endotransglycosylase activity
DB34_09700	COG1686	Belongs to the peptidase S11 family
DB34_09705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DB34_09720	COG0084	hydrolase, TatD family'
DB34_09725	COG1234	tRNA 3'-trailer cleavage
DB34_09735	COG0259	pyridoxamine-phosphate oxidase activity
DB34_09740	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DB34_09745	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DB34_09750	COG1764	response to oxidative stress
DB34_09755	COG0579	oxidoreductase
DB34_09765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DB34_09770	COG0602	queuosine metabolic process
DB34_09775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DB34_09785	COG0175	sulfate reduction
DB34_09790	COG0175	sulfate reduction
DB34_09805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DB34_09815	COG1519	Transferase
DB34_09820	COG1663	tetraacyldisaccharide 4'-kinase activity
DB34_09840	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DB34_09845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DB34_09850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DB34_09860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DB34_09895	COG1278	Cold shock
DB34_09900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DB34_09905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DB34_09910	COG1605	Chorismate mutase
DB34_09910	COG0077	Prephenate dehydratase
DB34_09915	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DB34_09920	COG3474	cytochrome
DB34_09930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DB34_09935	COG0606	chelatase, subunit chli
DB34_09940	COG0626	cystathionine gamma-synthase activity
DB34_09945	COG2897	thiosulfate sulfurtransferase activity
DB34_09950	COG0628	permease
DB34_09965	COG0792	nuclease activity
DB34_09975	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DB34_09980	COG0271	Belongs to the BolA IbaG family
DB34_09985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DB34_09990	COG0047	phosphoribosylformylglycinamidine synthase activity
DB34_10000	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DB34_10005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DB34_10010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DB34_10015	COG0861	Integral membrane protein TerC family
DB34_10030	COG1546	Belongs to the CinA family
DB34_10045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DB34_10050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DB34_10055	COG0508	dehydrogenase complex catalyzes the overall conversion of
DB34_10060	COG0022	dehydrogenase e1 component
DB34_10060	COG0508	dehydrogenase complex catalyzes the overall conversion of
DB34_10065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DB34_10070	COG0315	cyclic pyranopterin monophosphate synthase activity
DB34_10075	COG0134	indole-3-glycerol-phosphate synthase activity
DB34_10080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DB34_10090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DB34_10100	COG0149	triose-phosphate isomerase activity
DB34_10110	COG0504	CTP synthase activity
DB34_10115	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DB34_10120	COG0187	DNA topoisomerase II activity
DB34_10125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DB34_10130	COG0592	DNA-directed DNA polymerase activity
DB34_10135	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DB34_10140	COG0268	Binds directly to 16S ribosomal RNA
DB34_10145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DB34_10150	COG2226	methyltransferase
DB34_10155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DB34_10160	COG0756	dUTP diphosphatase activity
DB34_10165	COG1176	ABC-type spermidine putrescine transport system, permease component I
DB34_10170	COG1116	anion transmembrane transporter activity
DB34_10175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DB34_10180	COG0525	valine-tRNA ligase activity
DB34_10195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DB34_10215	COG1028	Short-chain dehydrogenase reductase Sdr
DB34_10220	COG0456	acetyltransferase
DB34_10225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DB34_10230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DB34_10235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DB34_10245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DB34_10250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DB34_10260	COG1349	DNA-binding transcription factor activity
DB34_10275	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DB34_10280	COG4988	ABC transporter
DB34_10305	COG0784	Response regulator, receiver
DB34_10325	COG2824	Alkylphosphonate utilization operon protein PhnA
DB34_10330	COG0814	amino acid
DB34_10340	COG0384	phenazine biosynthesis protein PhzF
DB34_10360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DB34_10360	COG1116	anion transmembrane transporter activity
DB34_10390	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DB34_10415	COG3293	Transposase
DB34_10425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DB34_10435	COG2233	PERMEase
DB34_10440	COG2351	hydroxyisourate hydrolase activity
DB34_10455	COG2072	flavoprotein involved in K transport
DB34_10485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DB34_10490	COG1129	ABC transporter
DB34_10490	COG0842	Transport permease protein
DB34_10495	COG0842	Transport permease protein
DB34_10520	COG3293	Transposase
DB34_10530	COG2855	membrane
DB34_10540	COG1657	PFAM Prenyltransferase squalene oxidase
DB34_10560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DB34_10565	COG1012	belongs to the aldehyde dehydrogenase family
DB34_10570	COG1902	pentaerythritol trinitrate reductase activity
DB34_10575	COG1733	regulation of RNA biosynthetic process
DB34_10580	COG0753	catalase activity
DB34_10595	COG3459	Glycosyltransferase 36 associated
DB34_10675	COG3293	Transposase
DB34_10735	COG1960	acyl-CoA dehydrogenase activity
DB34_10755	COG1231	oxidoreductase activity
DB34_10810	COG0625	glutathione transferase activity
DB34_10840	COG4977	sequence-specific DNA binding
DB34_10890	COG1301	dicarboxylic acid transport
DB34_10895	COG0500	methyltransferase
DB34_10900	COG2999	glutathione oxidoreductase activity
DB34_10905	COG2814	Major facilitator Superfamily
DB34_10910	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DB34_10960	COG0114	fumarate hydratase activity
DB34_11015	COG3293	Transposase
DB34_11040	COG0628	permease
DB34_11070	COG0493	'glutamate synthase
DB34_11085	COG1971	Probably functions as a manganese efflux pump
DB34_11095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DB34_11110	COG3293	Transposase
DB34_11120	COG0303	'Molybdopterin
DB34_11125	COG3058	Necessary for formate dehydrogenase activity
DB34_11130	COG2864	formate dehydrogenase
DB34_11135	COG0437	4 iron, 4 sulfur cluster binding
DB34_11140	COG0243	molybdopterin cofactor binding
DB34_11140	COG3383	formate dehydrogenase (NAD+) activity
DB34_11150	COG0248	Ppx GppA phosphatase
DB34_11155	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DB34_11160	COG1940	carbohydrate kinase activity
DB34_11165	COG0425	Belongs to the sulfur carrier protein TusA family
DB34_11170	COG1722	exodeoxyribonuclease VII activity
DB34_11175	COG0142	geranyltranstransferase activity
DB34_11180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DB34_11185	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DB34_11195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DB34_11200	COG0137	argininosuccinate synthase activity
DB34_11205	COG0545	Peptidyl-prolyl cis-trans isomerase
DB34_11215	COG0180	Tryptophanyl-tRNA synthetase
DB34_11240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DB34_11250	COG1914	H( )-stimulated, divalent metal cation uptake system
DB34_11425	COG3293	Transposase
DB34_11525	COG1783	phage Terminase large subunit
DB34_11610	COG0629	single-stranded DNA binding
DB34_11630	COG1396	sequence-specific DNA binding
DB34_11720	COG0745	RESPONSE REGULATOR receiver
DB34_11735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DB34_11735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DB34_11765	COG4608	Belongs to the ABC transporter superfamily
DB34_11770	COG2070	2-Nitropropane dioxygenase
DB34_11775	COG0671	phosphoesterase, PA-phosphatase related
DB34_11790	COG3511	phospholipase C
DB34_11855	COG1695	Transcriptional regulator
DB34_11865	COG1566	PFAM secretion protein HlyD family protein
DB34_11870	COG1289	transmembrane transporter activity
DB34_11880	COG1032	radical SAM domain protein
DB34_11895	COG0668	transmembrane transport
DB34_11910	COG1294	oxidase, subunit
DB34_11915	COG1271	oxidase subunit
DB34_11920	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DB34_11925	COG4988	ABC transporter
DB34_11930	COG3293	Transposase
DB34_11940	COG3128	pkhd-type hydroxylase
DB34_11945	COG4774	siderophore transport
DB34_11970	COG0252	asparaginase activity
DB34_11980	COG2985	domain, Protein
DB34_12010	COG0488	(ABC) transporter
DB34_12015	COG0583	DNA-binding transcription factor activity
DB34_12050	COG3547	Transposase (IS116 IS110 IS902 family)
DB34_12065	COG1064	alcohol dehydrogenase
DB34_12080	COG2814	Major facilitator Superfamily
DB34_12090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DB34_12095	COG1834	amidinotransferase
DB34_12105	COG0765	amino acid transport
DB34_12110	COG1126	abc transporter atp-binding protein
DB34_12175	COG0318	PFAM AMP-dependent synthetase and ligase
DB34_12185	COG0156	8-amino-7-oxononanoate synthase activity
DB34_12200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DB34_12225	COG0546	phosphoglycolate phosphatase activity
DB34_12230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DB34_12235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DB34_12250	COG0386	Belongs to the glutathione peroxidase family
DB34_12255	COG1136	(ABC) transporter
DB34_12265	COG0442	prolyl-tRNA aminoacylation
DB34_12275	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DB34_12285	COG1007	ATP synthesis coupled electron transport
DB34_12295	COG0713	ATP synthesis coupled electron transport
DB34_12305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DB34_12310	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DB34_12315	COG1034	ATP synthesis coupled electron transport
DB34_12325	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DB34_12330	COG0649	NAD binding
DB34_12335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DB34_12340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DB34_12365	COG0776	regulation of translation
DB34_12375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DB34_12380	COG0740	serine-type endopeptidase activity
DB34_12385	COG0544	peptidyl-prolyl cis-trans isomerase activity
DB34_12395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DB34_12395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DB34_12405	COG0513	Belongs to the DEAD box helicase family
DB34_12410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DB34_12415	COG0316	Belongs to the HesB IscA family
DB34_12420	COG2151	metal-sulfur cluster biosynthetic enzyme
DB34_12430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DB34_12435	COG0719	Fe-S assembly protein
DB34_12440	COG0396	ATPase activity
DB34_12445	COG0719	Fe-S assembly protein
DB34_12455	COG2733	membrane
DB34_12460	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DB34_12470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DB34_12475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DB34_12485	COG5265	(ABC) transporter
DB34_12495	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DB34_12500	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DB34_12525	COG0612	Peptidase, M16
DB34_12530	COG0312	modulator of DNA gyrase
DB34_12545	COG0109	protoheme IX farnesyltransferase activity
DB34_12555	COG2226	methyltransferase
DB34_12575	COG1522	sequence-specific DNA binding
DB34_12580	COG0492	ferredoxin-NADP+ reductase activity
DB34_12585	COG0583	DNA-binding transcription factor activity
DB34_12590	COG4957	zinc ion binding
DB34_12595	COG0776	regulation of translation
DB34_12610	COG0628	permease
DB34_12625	COG0776	regulation of translation
DB34_12630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DB34_12635	COG0416	fatty acid biosynthetic process
DB34_12640	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DB34_12655	COG2205	protein histidine kinase activity
DB34_12660	COG0745	RESPONSE REGULATOR receiver
DB34_12665	COG1846	Transcriptional regulator
DB34_12675	COG0242	peptide deformylase activity
DB34_12680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DB34_12685	COG0473	3-isopropylmalate dehydrogenase activity
DB34_12690	COG0066	3-isopropylmalate dehydratase activity
DB34_12695	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DB34_12700	COG0335	large ribosomal subunit rRNA binding
DB34_12705	COG0336	Belongs to the RNA methyltransferase TrmD family
DB34_12710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DB34_12715	COG0228	four-way junction DNA binding
DB34_12740	COG0564	pseudouridine synthase activity
DB34_12745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DB34_12765	COG3572	ergothioneine biosynthetic process
DB34_12770	COG2814	Major facilitator Superfamily
DB34_12775	COG1160	GTP binding
DB34_12800	COG0438	transferase activity, transferring glycosyl groups
DB34_12815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DB34_12820	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DB34_12825	COG0659	secondary active sulfate transmembrane transporter activity
DB34_12855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DB34_12865	COG1051	belongs to the nudix hydrolase family
DB34_12870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DB34_12875	COG1923	regulation of RNA biosynthetic process
DB34_12880	COG2204	response regulator
DB34_12905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DB34_12905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DB34_12910	COG0463	Glycosyl transferase, family 2
DB34_12965	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DB34_12975	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DB34_12990	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DB34_13000	COG0347	Belongs to the P(II) protein family
DB34_13010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DB34_13015	COG0586	Pfam SNARE associated Golgi protein
DB34_13060	COG3547	Transposase (IS116 IS110 IS902 family)
DB34_13140	COG4381	Mu-like prophage protein gp46
DB34_13175	COG4386	tail sheath protein
DB34_13215	COG0616	signal peptide processing
DB34_13260	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DB34_13395	COG0582	viral genome integration into host DNA
DB34_13405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DB34_13410	COG0483	inositol monophosphate 1-phosphatase activity
DB34_13415	COG1199	ATP-dependent helicase activity
DB34_13420	COG1278	Cold shock
DB34_13425	COG0412	Dienelactone hydrolase
DB34_13430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DB34_13435	COG0459	protein refolding
DB34_13540	COG2856	Zn peptidase
DB34_13560	COG3293	Transposase
DB34_13630	COG3293	Transposase
DB34_13665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DB34_13680	COG0210	DNA helicase
DB34_13695	COG3547	Transposase (IS116 IS110 IS902 family)
DB34_13795	COG3293	Transposase