locus-tag	class	description
APT_00001	ENOG4108UPT	UPF0178 protein
APT_00003	ENOG4105CZQ	inner membrane transport protein YdhC
APT_00005	ENOG4105W49	UPF0434 protein
APT_00006	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
APT_00007	ENOG4105K63	Thioredoxin
APT_00014	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
APT_00016	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
APT_00020	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
APT_00021	ENOG4105C26	Dehydrogenase
APT_00023	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
APT_00024	ENOG4105W8H	transhydrogenase (subunit alpha
APT_00025	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
APT_00026	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
APT_00027	ENOG410612Q	succinate dehydrogenase (cytochrome b-556 subunit)
APT_00033	ENOG4105BZA	Phosphoglycerate kinase
APT_00037	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
APT_00039	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
APT_00042	ENOG4105F4R	Transcriptional regulator mode
APT_00043	ENOG4105DJ9	glucan biosynthesis protein
APT_00044	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
APT_00045	ENOG4105CE4	GlcNAc 6-P deacetylase
APT_00048	ENOG4107QMP	dna polymerase iii subunits gamma and tau
APT_00049	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
APT_00050	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
APT_00051	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
APT_00052	ENOG4105KRF	dihydroneopterin aldolase
APT_00054	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
APT_00055	ENOG4105CAT	Cytidine monophosphate kinase
APT_00056	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
APT_00059	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
APT_00060	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
APT_00061	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
APT_00063	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
APT_00069	ENOG4105CNI	cell division protein FtsW
APT_00070	ENOG4105CJN	penicillin-binding protein
APT_00074	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
APT_00075	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
APT_00077	ENOG4105C2C	drug resistance transporter, Bcr CflA
APT_00079	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
APT_00080	ENOG4105DSW	Fusaric acid resistance protein
APT_00082	ENOG4108RG0	uracil-dna glycosylase
APT_00086	ENOG4105HFZ	Membrane
APT_00089	ENOG4105CCU	oxidase (Subunit III)
APT_00090	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
APT_00093	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
APT_00096	ENOG4105ESV	Glycosyl transferase, family 4
APT_00098	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
APT_00100	ENOG4105CD3	dihydroorotase
APT_00101	ENOG4105DC8	reductase
APT_00102	ENOG4105DP0	ferredoxin-NADP reductase
APT_00105	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
APT_00106	ENOG4108RHM	integral membrane protein
APT_00108	ENOG4107R1I	NAD-dependent malic enzyme
APT_00111	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
APT_00112	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
APT_00113	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
APT_00114	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
APT_00115	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
APT_00116	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
APT_00117	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
APT_00121	ENOG4105C85	amino acid
APT_00122	ENOG4108IJ6	ABC transporter
APT_00123	ENOG4105ECW	sulfate abc transporter
APT_00124	ENOG4108I5D	sulfate abc transporter
APT_00127	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
APT_00128	ENOG4108R6W	Transcriptional regulator, ARAC family
APT_00129	ENOG4105CPD	ethanolamine ammonia-lyase
APT_00130	ENOG4107FQ9	ethanolamine ammonia-lyase
APT_00133	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
APT_00134	ENOG4105BZS	acriflavin resistance protein
APT_00135	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
APT_00143	ENOG4105DCY	Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity)
APT_00145	ENOG4105BZU	Histidine kinase
APT_00149	ENOG4105C0Z	ABC transporter
APT_00150	ENOG4108IUZ	ABC transporter
APT_00157	ENOG4105W1Y	Transcriptional regulator
APT_00164	ENOG4108ZZ3	UPF0260 protein
APT_00167	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
APT_00172	ENOG4105Y49	secretion protein, HlyD family
APT_00176	ENOG4105EWU	Squalene--hopene cyclase
APT_00178	ENOG4105FE1	phytoene synthase
APT_00179	ENOG4105FBD	synthase
APT_00187	ENOG4105D3R	alkyl hydroperoxide reductase
APT_00188	ENOG4108X7C	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
APT_00190	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
APT_00191	ENOG4105F0N	pyrophosphate phospho-hydrolase
APT_00192	ENOG4105C5H	ABC transporter
APT_00193	ENOG4108YYQ	gCN5-related N-acetyltransferase
APT_00196	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
APT_00199	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
APT_00200	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
APT_00201	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
APT_00203	ENOG4108V1U	phospholipid-binding protein
APT_00206	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
APT_00209	ENOG4107RTZ	reductase
APT_00214	ENOG4108K4C	ec 3.1.3.12
APT_00215	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
APT_00216	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
APT_00218	ENOG4107RK2	ADP-ribose diphosphatase NudE
APT_00219	ENOG4108FN7	Aldo keto reductase
APT_00221	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
APT_00229	ENOG4105C85	amino acid
APT_00230	ENOG4107SFH	ImpB mucB samB family
APT_00233	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
APT_00236	ENOG4105D48	metallophosphoesterase
APT_00237	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
APT_00241	ENOG4105EIE	fructose-bisphosphate aldolase
APT_00242	ENOG4106HMZ	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
APT_00246	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
APT_00247	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
APT_00249	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
APT_00250	ENOG4105DZ1	carboxypeptidase
APT_00251	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
APT_00254	ENOG4105CSR	polyphosphate kinase 2
APT_00255	ENOG4108UJU	UPF0301 protein
APT_00256	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
APT_00258	ENOG4105EB3	Histidine kinase
APT_00259	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
APT_00260	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APT_00261	ENOG4105CFG	Acts as a chaperone (By similarity)
APT_00262	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
APT_00263	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
APT_00264	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
APT_00265	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
APT_00266	ENOG4105DC1	bifunctional purine biosynthesis protein purh
APT_00269	ENOG4105DXC	membrane
APT_00270	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
APT_00271	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
APT_00273	ENOG4108WRK	Transcriptional regulator
APT_00274	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
APT_00276	ENOG41090R7	Ferric uptake
APT_00280	ENOG4107QUT	magnesium and cobalt transport protein CorA
APT_00281	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
APT_00282	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
APT_00283	ENOG4107EFR	Flavocytochrome c
APT_00285	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
APT_00286	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
APT_00287	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
APT_00288	ENOG4105BZU	Histidine kinase
APT_00289	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
APT_00293	ENOG4105D6F	Phosphatase
APT_00294	ENOG4105C37	(CBS) domain
APT_00295	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
APT_00297	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
APT_00300	ENOG4105F6U	Short-chain dehydrogenase reductase Sdr
APT_00301	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
APT_00302	ENOG4105DXN	mazG family
APT_00304	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
APT_00318	ENOG4105EXC	Acyl-transferase
APT_00324	ENOG4105DXD	2-methylcitrate dehydratase
APT_00325	ENOG4105BZN	citrate synthase
APT_00326	ENOG4105CR4	methylisocitrate lyase
APT_00327	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
APT_00328	ENOG4105JHE	Major Facilitator Superfamily
APT_00331	ENOG4105C88	aminopeptidase
APT_00334	ENOG4105C9M	aspartyl-trna synthetase
APT_00337	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
APT_00338	ENOG4105C3G	gtp-binding protein
APT_00339	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
APT_00340	ENOG4107WK2	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
APT_00342	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
APT_00346	ENOG4105C7K	acetolactate synthase
APT_00349	ENOG4107R5T	Cysteine-rich domain
APT_00350	ENOG4107QR9	Iron-sulfur cluster binding protein
APT_00353	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
APT_00354	ENOG4105DHP	deoxycytidine triphosphate deaminase
APT_00358	ENOG410901P	UPF0249 protein
APT_00362	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
APT_00363	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
APT_00365	ENOG4105E4C	Lytic transglycosylase catalytic
APT_00366	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
APT_00368	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
APT_00377	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
APT_00386	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
APT_00389	ENOG4105EEQ	Na H antiporter
APT_00391	ENOG4105D05	Receptor
APT_00393	ENOG4105EHG	Permease protein
APT_00394	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
APT_00395	ENOG4105E2D	ec 3.2.1.52
APT_00396	ENOG4105RD7	BadF BadG BcrA BcrD
APT_00397	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APT_00403	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
APT_00404	ENOG4105E0X	reductase
APT_00410	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
APT_00416	ENOG410630Q	Methylamine utilization
APT_00425	ENOG4105C26	Dehydrogenase
APT_00455	ENOG4105E0K	tonB-dependent siderophore receptor
APT_00476	ENOG4105EXC	Acyl-transferase
APT_00481	ENOG4105C72	UPF0176 protein
APT_00505	ENOG4105EEQ	Na H antiporter
APT_00513	ENOG4105KPV	Transcriptional regulator
APT_00514	ENOG4105EMU	Dehydrogenase
APT_00522	ENOG4105C9K	Endothelin-converting enzyme 1
APT_00524	ENOG4108W9H	Tetr family transcriptional regulator
APT_00525	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
APT_00527	ENOG4105C1G	acyl-Coa dehydrogenase
APT_00531	ENOG4105TPV	
APT_00533	ENOG4105C26	Dehydrogenase
APT_00536	ENOG4105TW1	Carbohydrate-selective porin OprB
APT_00539	ENOG4105CSR	polyphosphate kinase 2
APT_00540	ENOG4105CJ3	phosphate transporter
APT_00542	ENOG4107R0V	Pyruvate dehydrogenase
APT_00543	ENOG4105CPP	Dehydrogenase, E1 component
APT_00544	ENOG4108EMS	branched-chain alpha-keto acid dehydrogenase subunit E2
APT_00545	ENOG4105VN1	Heat shock protein
APT_00547	ENOG4105CEP	NADH dehydrogenase
APT_00549	ENOG4105CKI	cobalamin synthesis protein
APT_00552	ENOG4105PGM	cation diffusion facilitator family transporter
APT_00553	ENOG4105DZ0	fad dependent oxidoreductase
APT_00554	ENOG4105EV9	Alpha Beta Hydrolase
APT_00557	ENOG4105EPD	Oligopeptide transporter, Opt family
APT_00563	ENOG4105D06	uba thif-type nad fad binding protein
APT_00565	ENOG4105CA9	Pyruvate kinase
APT_00570	ENOG4105CI3	gtp-binding protein typa
APT_00573	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
APT_00574	ENOG4105CAY	ferredoxin--nadp reductase
APT_00578	ENOG4108YZA	Nitrogen regulatory protein pii
APT_00579	ENOG4105C5F	glutamine synthetase
APT_00581	ENOG4105DZG	Dehydrogenase
APT_00584	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
APT_00585	ENOG4105DWV	Homoserine O-trans-acetylase
APT_00586	ENOG4105DWV	Homoserine O-trans-acetylase
APT_00587	ENOG4105C1J	atp-dependent rna helicase
APT_00589	ENOG4107B2H	carbonic anhydrase
APT_00591	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APT_00592	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
APT_00593	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
APT_00594	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
APT_00595	ENOG4105C3F	Signal peptidase i
APT_00596	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
APT_00597	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
APT_00598	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
APT_00599	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
APT_00600	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
APT_00602	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
APT_00603	ENOG4105DZP	Membrane-associated zinc metalloprotease
APT_00604	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APT_00606	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
APT_00607	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
APT_00608	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
APT_00609	ENOG4105GYT	Protein of unknown function (DUF1009)
APT_00610	ENOG4108UYE	Lactoylglutathione lyase
APT_00612	ENOG4105VG0	50S ribosomal protein l34
APT_00613	ENOG41087PG	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
APT_00614	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
APT_00615	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
APT_00616	ENOG4105CAS	nag kinase
APT_00617	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
APT_00618	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
APT_00620	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
APT_00621	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
APT_00623	ENOG4108ZNX	Heat shock protein
APT_00625	ENOG4107TNS	sigma 54 modulation protein ribosomal protein S30ea
APT_00627	ENOG4105QVC	MOSC domain-containing protein
APT_00628	ENOG4108IUZ	ABC transporter
APT_00631	ENOG4105C2X	Arabinose 5-phosphate isomerase
APT_00633	ENOG4105C2N	RNA methyltransferase TrmH family group 3
APT_00635	ENOG4105EMU	Dehydrogenase
APT_00636	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
APT_00637	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
APT_00638	ENOG4107SZR	mannose-6-phosphate isomerase
APT_00641	ENOG4105EGS	Mechanosensitive ion channel
APT_00643	ENOG4105DHJ	ABC, transporter
APT_00644	ENOG4105CY3	ABC transporter, permease
APT_00650	ENOG4105C85	amino acid
APT_00652	ENOG4105C26	Dehydrogenase
APT_00655	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
APT_00661	ENOG4108WBT	adenosyltransferase
APT_00666	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
APT_00667	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
APT_00668	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
APT_00670	ENOG4105CV8	reductase
APT_00672	ENOG4105CQ7	ATP-dependent helicase
APT_00674	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
APT_00677	ENOG4105DBV	ornithine carbamoyltransferase
APT_00678	ENOG4105C8Y	Acetylornithine aminotransferase
APT_00682	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
APT_00683	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
APT_00684	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
APT_00685	ENOG4105DTN	riboflavin biosynthesis protein ribF
APT_00686	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
APT_00687	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
APT_00689	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
APT_00690	ENOG4105C8S	subunit m
APT_00691	ENOG4107AQZ	Membrane
APT_00693	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
APT_00696	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
APT_00700	ENOG4105CN1	protease
APT_00701	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
APT_00703	ENOG4105C79	DNA protecting protein DprA
APT_00704	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
APT_00705	ENOG4105CD3	dihydroorotase
APT_00706	ENOG4105CXT	aspartate transcarbamylase
APT_00707	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
APT_00708	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
APT_00710	ENOG4105D6Z	AFG1 family ATPase
APT_00712	ENOG4105C7S	Dehydrogenase
APT_00713	ENOG4107QN2	dihydrolipoyl dehydrogenase
APT_00716	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
APT_00727	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
APT_00728	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
APT_00729	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
APT_00730	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
APT_00731	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
APT_00734	ENOG4105D49	3-dehydroquinate synthase
APT_00736	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
APT_00737	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
APT_00738	ENOG4105CEV	competence damage-inducible protein
APT_00739	ENOG4105DK7	lysyl-tRNA synthetase
APT_00742	ENOG4105D6S	protein involved in catabolism of external DNA
APT_00743	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
APT_00744	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
APT_00746	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
APT_00747	ENOG4105GCF	PGAM
APT_00749	ENOG4105CEC	DNA methylase N-4 N-6
APT_00750	ENOG4105CA0	peroxidase
APT_00753	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
APT_00754	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
APT_00755	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
APT_00756	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
APT_00760	ENOG4108RCM	Nitroreductase
APT_00762	ENOG4107RGH	Aldehyde dehydrogenase
APT_00773	ENOG4105DFP	Integrase
APT_00803	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
APT_00804	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
APT_00805	ENOG4105YVS	arsR family transcriptional regulator
APT_00807	ENOG4108CHM	Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases
APT_00808	ENOG4105CMR	udp-glucose 4-epimerase
APT_00811	ENOG4105CH7	arginosuccinase
APT_00814	ENOG4105E2X	shikimate dehydrogenase
APT_00815	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
APT_00820	ENOG4105DJV	ribulose-phosphate 3-epimerase
APT_00821	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
APT_00822	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
APT_00823	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
APT_00825	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
APT_00829	ENOG4105FDK	ABC transporter
APT_00834	ENOG4105DSW	Fusaric acid resistance protein
APT_00835	ENOG4105DSW	Fusaric acid resistance protein
APT_00839	ENOG4105KWW	Biogenesis protein
APT_00840	ENOG4107QX9	Thiol disulfide interChange protein
APT_00841	ENOG4105DA4	cytochrome c-type biogenesis protein
APT_00842	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
APT_00844	ENOG41060IM	Heme exporter protein
APT_00852	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
APT_00858	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APT_00860	ENOG4105CSH	Transporter
APT_00867	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
APT_00868	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
APT_00869	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
APT_00870	ENOG4108VZM	50s ribosomal protein L10
APT_00871	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
APT_00872	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
APT_00873	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
APT_00874	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
APT_00875	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
APT_00876	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
APT_00877	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
APT_00878	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
APT_00879	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
APT_00880	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
APT_00881	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APT_00882	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
APT_00883	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
APT_00884	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
APT_00885	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
APT_00886	ENOG41083MP	50s ribosomal protein l29
APT_00887	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
APT_00888	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
APT_00889	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
APT_00890	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APT_00891	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
APT_00892	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
APT_00893	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
APT_00894	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
APT_00895	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
APT_00896	ENOG41084HQ	50S ribosomal protein L30
APT_00897	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
APT_00899	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
APT_00900	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APT_00901	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
APT_00902	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
APT_00903	ENOG4108ZT0	50S ribosomal protein l17
APT_00905	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
APT_00906	ENOG4105D7T	ABC transporter
APT_00909	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
APT_00911	ENOG4105BZS	acriflavin resistance protein
APT_00912	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
APT_00913	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
APT_00915	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
APT_00916	ENOG4105CEC	DNA methylase N-4 N-6
APT_00921	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
APT_00923	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
APT_00924	ENOG4105BZ1	(ABC) transporter
APT_00926	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
APT_00927	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
APT_00929	ENOG4105CN1	protease
APT_00931	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
APT_00932	ENOG4105C7B	Threonine dehydratase
APT_00933	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
APT_00934	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
APT_00935	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
APT_00937	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
APT_00938	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
APT_00940	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
APT_00941	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
APT_00942	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
APT_00943	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
APT_00944	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
APT_00945	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
APT_00946	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
APT_00950	ENOG4105BZ1	(ABC) transporter
APT_00951	ENOG4108WYP	Transcriptional regulator
APT_00952	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
APT_00953	ENOG4107QMS	site-determining protein
APT_00954	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
APT_00956	ENOG4105CBX	hi0933 family
APT_00957	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
APT_00959	ENOG4105RQ9	TPR repeat-containing protein
APT_00960	ENOG4108VJ1	Transcriptional regulator (CarD family
APT_00961	ENOG4105FFC	UPF0187 protein
APT_00962	ENOG4105C4W	S-formylglutathione hydrolase
APT_00965	ENOG4105CAK	Cell division ATP-binding protein ftsE
APT_00970	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
APT_00971	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
APT_00972	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
APT_00975	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
APT_00976	ENOG4105DEI	Mannitol dehydrogenase
APT_00977	ENOG41082BR	50S ribosomal protein L35
APT_00978	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
APT_00979	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
APT_00980	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
APT_00986	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
APT_00987	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
APT_00989	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
APT_00990	ENOG4105DC7	peptidase M24
APT_00991	ENOG4107RQ5	Methylates ribosomal protein L11 (By similarity)
APT_00993	ENOG4105W5Q	DNA repair protein (RadC
APT_00994	ENOG4105W5Q	DNA repair protein (RadC
APT_00995	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
APT_00996	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
APT_01000	ENOG4108ZNX	Heat shock protein
APT_01002	ENOG41082FS	50S ribosomal protein L31
APT_01004	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
APT_01006	ENOG4107QT7	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
APT_01007	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
APT_01009	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
APT_01010	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
APT_01012	ENOG4105EAH	synthase
APT_01013	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
APT_01014	ENOG4107SW0	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
APT_01017	ENOG4105M4E	phosphohistidine phosphatase, SixA
APT_01018	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
APT_01023	ENOG4108R9S	DSBA oxidoreductase
APT_01024	ENOG4105C37	(CBS) domain
APT_01025	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
APT_01027	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
APT_01029	ENOG4105CFU	surface antigen
APT_01032	ENOG4108IGT	Dipeptidase
APT_01033	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
APT_01036	ENOG4105M00	molybdopterin converting factor, subunit 1
APT_01037	ENOG4108ZAF	Molybdopterin
APT_01038	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
APT_01039	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
APT_01041	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
APT_01042	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
APT_01043	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
APT_01044	ENOG4105W0E	50S ribosomal protein L33
APT_01046	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
APT_01050	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
APT_01052	ENOG4105CB5	ATP-dependent DNA helicase recG
APT_01053	ENOG4107NKQ	Flavinator of succinate dehydrogenase
APT_01056	ENOG4105DHU	Bile acid
APT_01057	ENOG4105DY8	decarboxylase
APT_01060	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
APT_01061	ENOG4105M85	Bola protein
APT_01063	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
APT_01066	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
APT_01067	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
APT_01068	ENOG4105MJ2	Competence protein
APT_01069	ENOG4105VW4	glutaredoxin 3
APT_01072	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
APT_01073	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
APT_01074	ENOG4105CFH	Aspartokinase
APT_01075	ENOG4105EA8	2-Nitropropane dioxygenase
APT_01077	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
APT_01078	ENOG4105CUT	histidyl-tRNA synthetase
APT_01079	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
APT_01081	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
APT_01084	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
APT_01085	ENOG4105CUB	amino acid
APT_01088	ENOG4105CVE	Lytic murein transglycosylase
APT_01089	ENOG4105K6T	rare lipoprotein A
APT_01090	ENOG4105DZ1	carboxypeptidase
APT_01091	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
APT_01094	ENOG4105F8V	Hydrolase, tatD family
APT_01097	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
APT_01098	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
APT_01099	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
APT_01100	ENOG4108Z9K	Osmotically inducible protein
APT_01101	ENOG4105DWT	malate dehydrogenase (quinone)
APT_01103	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
APT_01104	ENOG4107RJX	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
APT_01105	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
APT_01107	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
APT_01108	ENOG4105C11	sulfate adenylyltransferase), subunit 2
APT_01111	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
APT_01113	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
APT_01114	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
APT_01118	ENOG4105HHA	aminodeoxychorismate lyase
APT_01119	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
APT_01120	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
APT_01123	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
APT_01129	ENOG4105VEQ	Cold shock protein
APT_01130	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
APT_01131	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
APT_01132	ENOG4105CQC	Prephenate dehydratase
APT_01133	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
APT_01134	ENOG4105XUA	cytochrome c
APT_01136	ENOG4108JQ1	Dehydrogenase
APT_01137	ENOG4105C0P	Mg chelatase subunit ChlI
APT_01138	ENOG4105C28	cystathionine
APT_01139	ENOG4105KHC	sulfurtransferase
APT_01140	ENOG4105IPI	Membrane
APT_01142	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
APT_01143	ENOG41082FP	UPF0102 protein
APT_01147	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
APT_01148	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
APT_01150	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
APT_01151	ENOG4107QPR	SAICAR synthetase
APT_01152	ENOG4105C83	adenylosuccinate lyase
APT_01153	ENOG4108ZCF	integral membrane protein
APT_01154	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
APT_01156	ENOG4107TH8	cina domain protein
APT_01160	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
APT_01161	ENOG4107QN2	dihydrolipoyl dehydrogenase
APT_01162	ENOG4105C7S	Dehydrogenase
APT_01163	ENOG4105CPP	Dehydrogenase, E1 component
APT_01164	ENOG4108JYK	Dehydrogenase
APT_01165	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
APT_01166	ENOG4105DK0	Indole-3-glycerol phosphate synthase
APT_01167	ENOG4107QYG	anthranilate phosphoribosyltransferase
APT_01168	ENOG4105DDQ	anthranilate synthase
APT_01169	ENOG4105CRQ	synthase (Component I)
APT_01171	ENOG4105CP7	Triose-phosphate isomerase
APT_01173	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
APT_01174	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
APT_01175	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
APT_01176	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
APT_01177	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
APT_01178	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
APT_01180	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
APT_01181	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
APT_01182	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
APT_01183	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
APT_01184	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
APT_01185	ENOG4105F38	ABC transporter, permease
APT_01186	ENOG4108IY8	ABC, transporter
APT_01187	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
APT_01188	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
APT_01191	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
APT_01192	ENOG4105DFP	Integrase
APT_01207	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
APT_01225	ENOG4105CHR	reductase
APT_01227	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
APT_01228	ENOG4107XZX	Involved in the transcription termination process (By similarity)
APT_01229	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
APT_01232	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
APT_01233	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
APT_01234	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
APT_01235	ENOG4105E98	transcriptional regulator DeoR family
APT_01236	ENOG4105C9U	ATP-dependent DNA helicase RecQ
APT_01238	ENOG4108JJ8	(ABC) transporter
APT_01239	ENOG4108JJ9	ABC, transporter
APT_01244	ENOG41074H6	response regulator
APT_01245	ENOG4105C5H	ABC transporter
APT_01248	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
APT_01249	ENOG4105C44	Serine transporter
APT_01251	ENOG4105JAB	phenazine biosynthesis protein, phzf family
APT_01255	ENOG4105D7T	ABC transporter
APT_01258	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
APT_01261	ENOG4105C5R	Aminotransferase
APT_01266	ENOG4105C7W	Xanthine dehydrogenase
APT_01268	ENOG4105C2W	permease
APT_01269	ENOG4105VT2	5-hydroxyisourate hydrolase
APT_01272	ENOG4105E1J	oxidoreductase
APT_01274	ENOG4107QUY	Guanine deaminase
APT_01275	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
APT_01281	ENOG4105D0S	secretion protein (HlyD
APT_01282	ENOG4105CJ1	ABC, transporter
APT_01283	ENOG4105CMI	transporter
APT_01286	ENOG4105HMI	Membrane
APT_01288	ENOG4105EWU	Squalene--hopene cyclase
APT_01292	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
APT_01293	ENOG4105C26	Dehydrogenase
APT_01294	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
APT_01295	ENOG4105KVH	Transcriptional regulator
APT_01297	ENOG4108YZN	class I peptide chain release factor
APT_01299	ENOG4105E2V	Glycosyltransferase 36
APT_01300	ENOG4105CPN	adenine deaminase
APT_01301	ENOG4105XYF	acetyltransferase
APT_01302	ENOG4105DWF	phosphomethylpyrimidine kinase
APT_01305	ENOG4105CNM	Receptor
APT_01306	ENOG4105CQ0	ABC transporter
APT_01317	ENOG4107RGD	Major Facilitator superfamily
APT_01322	ENOG4108UIN	ybak prolyl-trna synthetase associated region
APT_01323	ENOG4105C57	major facilitator superfamily
APT_01326	ENOG4108ZZF	transport protein (ExbD)
APT_01330	ENOG4105E0K	tonB-dependent siderophore receptor
APT_01332	ENOG4108KPJ	rna polymerase sigma factor
APT_01333	ENOG4105E0K	tonB-dependent siderophore receptor
APT_01335	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
APT_01336	ENOG4108J8Z	aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein
APT_01337	ENOG4105E2Y	ABC, transporter
APT_01338	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
APT_01340	ENOG4105E2B	Taurine dioxygenase
APT_01344	ENOG4105DJB	Major Facilitator Superfamily
APT_01345	ENOG4106NZI	LysR family Transcriptional regulator
APT_01348	ENOG4105CPN	adenine deaminase
APT_01349	ENOG4108MP6	LysR family Transcriptional regulator
APT_01350	ENOG4105C0A	alcohol dehydrogenase
APT_01352	ENOG4105C26	Dehydrogenase
APT_01354	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
APT_01356	ENOG4105MRR	Transcriptional regulator (By similarity)
APT_01358	ENOG4105EIG	urea carboxylase-associated protein 1
APT_01365	ENOG4108YNN	Heme oxygenase
APT_01367	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
APT_01368	ENOG4105EHG	Permease protein
APT_01369	ENOG4107R4I	Periplasmic binding protein
APT_01371	ENOG4105KST	dependent repressor
APT_01372	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
APT_01377	ENOG4105CPT	Alpha beta hydrolase
APT_01378	ENOG4105BZU	Histidine kinase
APT_01383	ENOG4105CKI	cobalamin synthesis protein
APT_01384	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
APT_01385	ENOG4105EMU	Dehydrogenase
APT_01386	ENOG4105E7U	AraC family transcriptional regulator
APT_01389	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
APT_01393	ENOG4108JJA	ABC, transporter
APT_01398	ENOG4105CT4	transporter
APT_01403	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
APT_01406	ENOG4105D4R	Catalyzes the desulfonation of aliphatic sulfonates (By similarity)
APT_01412	ENOG4105E0K	tonB-dependent siderophore receptor
APT_01415	ENOG41082EK	Restriction modification system DNA (Specificity
APT_01416	ENOG4105DZR	Type I site-specific deoxyribonuclease
APT_01429	ENOG4105D9P	serine threonine protein kinase
APT_01432	ENOG4105CVR	type I restriction-modification system
APT_01438	ENOG4105E4C	Lytic transglycosylase catalytic
APT_01446	ENOG4105CK2	sodium dicarboxylate symporter
APT_01447	ENOG4105FQ6	thiopurine methyltransferase
APT_01448	ENOG4105E9S	glutaredoxin 2
APT_01449	ENOG4105IE8	Alpha-ketoglutarate permease
APT_01451	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
APT_01461	ENOG4105C9Q	fumarate hydratase class II
APT_01465	ENOG4105DZG	Dehydrogenase
APT_01473	ENOG4105IPI	Membrane
APT_01479	ENOG4105BZ8	glutamate synthase
APT_01482	ENOG4108UI1	Probably functions as a manganese efflux pump (By similarity)
APT_01483	ENOG4108K3A	Glutathione S-transferase
APT_01484	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
APT_01486	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
APT_01487	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
APT_01488	ENOG4105F46	Necessary for formate dehydrogenase activity (By similarity)
APT_01489	ENOG4108MG3	formate dehydrogenase
APT_01490	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
APT_01491	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
APT_01492	ENOG4105C9X	ppx gppa phosphatase
APT_01493	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
APT_01494	ENOG4105DKQ	ROK family
APT_01495	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
APT_01496	ENOG41083BM	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
APT_01497	ENOG4105CTB	Polyprenyl synthetase
APT_01498	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
APT_01499	ENOG4105DX0	Hemolysin A
APT_01501	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
APT_01502	ENOG4105CDH	Citrulline--aspartate ligase
APT_01503	ENOG4108V1T	peptidylprolyl cis-trans isomerase
APT_01505	ENOG4105C31	Tryptophanyl-tRNA synthetase
APT_01507	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
APT_01510	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
APT_01513	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
APT_01516	ENOG4108JQ7	(ABC) transporter
APT_01517	ENOG4105EA8	2-Nitropropane dioxygenase
APT_01526	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
APT_01530	ENOG4105NTW	Transcriptional regulator
APT_01533	ENOG4105J12	Multidrug resistance protein mdtN
APT_01534	ENOG4108MI0	Resistance protein
APT_01539	ENOG4105D64	Mechanosensitive ion channel
APT_01543	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
APT_01544	ENOG4105C4M	(Ubiquinol oxidase) subunit I
APT_01545	ENOG4108JJ8	(ABC) transporter
APT_01546	ENOG4108JJ9	ABC, transporter
APT_01548	ENOG4107E2E	PKHD-type hydroxylase
APT_01549	ENOG4108ESX	Receptor
APT_01553	ENOG4105HDK	L-asparaginase
APT_01554	ENOG4105CEB	Aspartate aminotransferase
APT_01557	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
APT_01562	ENOG4105C5H	ABC transporter
APT_01563	ENOG4105DDW	LysR family Transcriptional regulator
APT_01565	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
APT_01566	ENOG4105DQ4	alcohol dehydrogenase
APT_01568	ENOG4108Z9Z	response to DNA damage stimulus
APT_01570	ENOG4108302	MgtC SapB transporter
APT_01574	ENOG4105CFN	oxalyl-CoA decarboxylase
APT_01577	ENOG4105F6U	Short-chain dehydrogenase reductase Sdr
APT_01579	ENOG4105CHR	reductase
APT_01582	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
APT_01591	ENOG4108VN5	Inherit from COG: PepSY-associated TM helix
APT_01599	ENOG4105DHQ	Histidine kinase
APT_01617	ENOG4105CT4	transporter
APT_01622	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
APT_01623	ENOG4105VGJ	Virulence-associated protein
APT_01627	ENOG4107UNZ	domain protein
APT_01638	ENOG4108Z4X	TRANSCRIPTIONal
APT_01641	ENOG4105MP0	transposase
APT_01643	ENOG4105D06	uba thif-type nad fad binding protein
APT_01648	ENOG4105MP0	transposase
APT_01659	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
APT_01665	ENOG4105MP0	transposase
APT_01672	ENOG4105F9F	transposase
APT_01676	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
APT_01684	ENOG4107SVC	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
APT_01703	ENOG4107RCI	amp-dependent synthetase and ligase
APT_01705	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
APT_01708	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
APT_01713	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
APT_01714	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
APT_01715	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
APT_01719	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
APT_01721	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
APT_01723	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
APT_01724	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
APT_01725	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
APT_01726	ENOG4105D65	subunit l
APT_01727	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
APT_01728	ENOG4105DF2	NADH dehydrogenase subunit j
APT_01729	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
APT_01730	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
APT_01732	ENOG4107QIZ	NADH dehydrogenase
APT_01733	ENOG4105GKE	subunit e
APT_01734	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
APT_01735	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
APT_01736	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
APT_01738	ENOG4105K70	DNA-binding protein
APT_01739	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
APT_01740	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
APT_01741	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
APT_01742	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
APT_01743	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
APT_01745	ENOG4105C1J	atp-dependent rna helicase
APT_01746	ENOG4107QS4	23S rRNA
APT_01747	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
APT_01748	ENOG4105VG1	fes assembly suf system protein
APT_01750	ENOG4105C9B	Cysteine desulfurase
APT_01751	ENOG4105JRK	feS assembly protein SufD
APT_01755	ENOG4106BRA	Membrane
APT_01756	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
APT_01758	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
APT_01759	ENOG4105KDC	50s ribosomal protein l28
APT_01761	ENOG4108JJ7	ABC transporter
APT_01763	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
APT_01764	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
APT_01766	ENOG4105CTD	carboxy-peptidase
APT_01768	ENOG4105D98	threonine synthase
APT_01769	ENOG4105C1V	Peptidase, M16
APT_01770	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
APT_01774	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
APT_01775	ENOG4105BZ9	Cytochrome C oxidase, subunit I
APT_01777	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
APT_01782	ENOG4105F7P	transcriptional regulator AsnC family
APT_01783	ENOG4105C3M	thioredoxin reductase
APT_01784	ENOG4108PZW	LysR family Transcriptional regulator
APT_01786	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
APT_01788	ENOG4105CJR	Integral membrane protein (MviN
APT_01790	ENOG4105WJX	transcriptional regulator MERR family
APT_01791	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
APT_01792	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
APT_01793	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
APT_01794	ENOG41082R8	50S ribosomal protein l32
APT_01797	ENOG4105E0F	Histidine kinase
APT_01798	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
APT_01799	ENOG41090HR	transcriptional regulator
APT_01801	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
APT_01802	ENOG4105K5G	30S ribosomal protein S21
APT_01803	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
APT_01804	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
APT_01805	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
APT_01806	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
APT_01807	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
APT_01808	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
APT_01809	ENOG4105K5M	30s ribosomal protein S16
APT_01814	ENOG4105EI2	Pseudouridine synthase
APT_01815	ENOG4105D1H	recombination factor protein RarA
APT_01819	ENOG4105D1K	glutamate--cysteine ligase
APT_01820	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
APT_01822	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
APT_01823	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
APT_01827	ENOG4107TYR	Glycosyl Transferase
APT_01828	ENOG4105CAQ	asparagine synthetase
APT_01829	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
APT_01830	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
APT_01831	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
APT_01832	ENOG4105CHH	sulfate transporter
APT_01833	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
APT_01836	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
APT_01839	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
APT_01840	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
APT_01841	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
APT_01846	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
APT_01853	ENOG4105CMR	udp-glucose 4-epimerase
APT_01855	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
APT_01857	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
APT_01860	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
APT_01862	ENOG4108YZA	Nitrogen regulatory protein pii
APT_01863	ENOG4105D7W	serine acetyltransferase
APT_01864	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
APT_01873	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
APT_01874	ENOG4105ECY	inositol monophosphatase
APT_01875	ENOG4105DVT	helicase
APT_01878	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
APT_01879	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
APT_01891	ENOG4105BZU	Histidine kinase
APT_01895	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
APT_01896	ENOG4105C25	Primosomal protein n'
APT_01900	ENOG4105M6F	mutator MutT protein
APT_01903	ENOG4105NWN	ApaG protein
APT_01904	ENOG4105EUJ	GTP cyclohydrolase i
APT_01906	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
APT_01913	ENOG4105Y49	secretion protein, HlyD family
APT_01919	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
APT_01920	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
APT_01921	ENOG4108R6K	riboflavin synthase, subunit alpha
APT_01924	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
APT_01925	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
APT_01926	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
APT_01930	ENOG4105C7N	Xanthine uracil vitamin C permease
APT_01935	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
APT_01936	ENOG4105K46	50S ribosomal protein l27
APT_01937	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APT_01938	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
APT_01940	ENOG4105Y2X	UPF0335 protein
APT_01941	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
APT_01945	ENOG4107YUR	Cell division protein mraZ
APT_01946	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
APT_01949	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
APT_01951	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
APT_01952	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
APT_01954	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
APT_01955	ENOG4105DFU	Cell wall formation (By similarity)
APT_01956	ENOG4105D4A	Cell wall formation (By similarity)
APT_01957	ENOG4105CPF	Cell wall formation (By similarity)
APT_01958	ENOG4108UFP	Essential cell division protein (By similarity)
APT_01959	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
APT_01961	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
APT_01962	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APT_01963	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
APT_01964	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
APT_01965	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
APT_01966	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
APT_01970	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
APT_01973	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
APT_01974	ENOG4108RWI	nicotinamidase
APT_01978	ENOG4105E3B	Multicopper oxidase
APT_01980	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
APT_01981	ENOG4108ZP8	Acetolactate synthase small subunit
APT_01982	ENOG4105C7K	acetolactate synthase
APT_01983	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
APT_01984	ENOG4105EAC	phosphoserine phosphatase
APT_01987	ENOG4105C1J	atp-dependent rna helicase
APT_01991	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
APT_01993	ENOG4105CUB	amino acid
APT_01994	ENOG4105D52	delta-aminolevulinic acid dehydratase
APT_01995	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
APT_01996	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
APT_01997	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
APT_01998	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
APT_01999	ENOG4105CE9	30S ribosomal protein S2
APT_02003	ENOG4105CRQ	synthase (Component I)
APT_02004	ENOG4105C0B	DNA polymerase III (alpha subunit)
APT_02005	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
APT_02006	ENOG4105M4H	endoribonuclease L-psp
APT_02008	ENOG4105CHM	Aminotransferase
APT_02009	ENOG4105CHM	Aminotransferase
APT_02010	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
APT_02015	ENOG4105EPH	radical SAM domain protein
APT_02016	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
APT_02017	ENOG4105C5H	ABC transporter
APT_02019	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
APT_02020	ENOG41062D9	Histidine kinase
APT_02022	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
APT_02023	ENOG4105C22	threonyL-tRNA synthetase
APT_02027	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
APT_02030	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
APT_02031	ENOG4105CUV	Homoserine Kinase
APT_02032	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
APT_02041	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
APT_02042	ENOG4105C03	ribonuclease
APT_02043	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
APT_02044	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
APT_02045	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
APT_02046	ENOG4108Z03	MAF-like protein
APT_02048	ENOG41088BU	Domain of unknown function (DUF329)
APT_02074	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
APT_02094	ENOG4105Y2X	UPF0335 protein
APT_02102	ENOG4105CXG	d-lactate dehydrogenase
APT_02107	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
APT_02110	ENOG4108WUH	Transcriptional regulator, TetR family
APT_02111	ENOG4105CEP	NADH dehydrogenase
APT_02112	ENOG4105C26	Dehydrogenase
APT_02114	ENOG4105F27	Major Facilitator
APT_02116	ENOG4108YYH	Nadph-dependent fmn reductase
APT_02117	ENOG4105EUB	pirin domain protein
APT_02118	ENOG4105CC0	LysR family Transcriptional regulator
APT_02127	ENOG4105E7W	lamb ycsf family protein
APT_02128	ENOG4107R7A	Allophanate hydrolase subunit 2
APT_02132	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
APT_02134	ENOG4105CHM	Aminotransferase
APT_02139	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
APT_02140	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
APT_02141	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
APT_02144	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
APT_02158	ENOG4105DZR	Type I site-specific deoxyribonuclease
APT_02160	ENOG4107EEY	synthase
APT_02161	ENOG4107UNZ	domain protein
APT_02169	ENOG4107RSM	transcriptional regulator
APT_02170	ENOG4105DSW	Fusaric acid resistance protein
APT_02176	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
APT_02177	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
APT_02178	ENOG41081BE	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
APT_02179	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
APT_02180	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
APT_02182	ENOG4105C75	arginyL-tRNA synthetase
APT_02183	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
APT_02184	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
APT_02185	ENOG4105CGK	Exodeoxyribonuclease III
APT_02190	ENOG4105JIE	May be involved in the transport of PQQ or its precursor to the periplasm (By similarity)
APT_02191	ENOG41086XE	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity)
APT_02192	ENOG4105Z85	coenzyme PQQ synthesis
APT_02193	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
APT_02195	ENOG4108S10	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
APT_02197	ENOG4105CHM	Aminotransferase
APT_02198	ENOG4105D6E	homoserine dehydrogenase
APT_02199	ENOG4105CBT	Fructose-1,6-bisphosphatase
APT_02200	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
APT_02201	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
APT_02203	ENOG4105EHG	Permease protein
APT_02204	ENOG4105E0A	ABC, transporter
APT_02205	ENOG4105CNG	UPF0061 protein
APT_02206	ENOG4105CM2	brancheD-chain amino acid aminotransferase
APT_02207	ENOG4105C2M	dna polymerase I
APT_02210	ENOG4105CSH	Transporter
APT_02213	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
APT_02214	ENOG4105C4M	(Ubiquinol oxidase) subunit I
APT_02217	ENOG4105C85	amino acid
APT_02219	ENOG4105DZG	Dehydrogenase
APT_02221	ENOG41090U3	tautomerase
APT_02224	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
APT_02225	ENOG4107SJI	Dehydrogenase
APT_02226	ENOG4105BZ8	glutamate synthase
APT_02229	ENOG4105CD3	dihydroorotase
APT_02230	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
APT_02232	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
APT_02233	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
APT_02235	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
APT_02237	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
APT_02238	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
APT_02240	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
APT_02244	ENOG4105CF1	Alkylated DNA repair protein
APT_02246	ENOG41067QW	Transcriptional regulator
APT_02248	ENOG4108UMI	ABC transporter, permease
APT_02249	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
APT_02250	ENOG4105D01	(LipO)protein
APT_02251	ENOG4105CQB	FAD linked oxidase domain protein
APT_02252	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
APT_02254	ENOG41090MY	MarR family Transcriptional regulator
APT_02255	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
APT_02256	ENOG4108VQN	4-hydroxyphenylacetate 3-monooxygenase reductase
APT_02257	ENOG4105MP9	class II Aldolase
APT_02262	ENOG4108Q89	anthranilate 1,2-dioxygenase large subunit
APT_02266	ENOG4105C26	Dehydrogenase
APT_02268	ENOG4105JHE	Major Facilitator Superfamily
APT_02271	ENOG4105NRK	Binding-protein-dependent transport systems, inner membrane component
APT_02272	ENOG4105D81	ABC transporter, permease
APT_02273	ENOG4107TYH	extracellular solute-binding protein family 1
APT_02274	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
APT_02275	ENOG4105C26	Dehydrogenase
APT_02278	ENOG4107E2E	PKHD-type hydroxylase
APT_02281	ENOG4108IU3	tonb-dependent siderophore receptor
APT_02283	ENOG4108ZZF	transport protein (ExbD)
APT_02289	ENOG4105CK2	sodium dicarboxylate symporter
APT_02296	ENOG4105F27	Major Facilitator
APT_02298	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
APT_02299	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
APT_02300	ENOG4105EFT	decarboxylase
APT_02302	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
APT_02303	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
APT_02304	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
APT_02306	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
APT_02312	ENOG4105DSW	Fusaric acid resistance protein
APT_02313	ENOG4106HK8	GPR1 FUN34 yaaH family protein
APT_02314	ENOG4105CGU	Enoyl-CoA hydratase
APT_02315	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
APT_02317	ENOG4105FAV	ABC, transporter
APT_02318	ENOG4105D5T	phosphonate abc transporter
APT_02320	ENOG4105MYN	Zinc uptake regulation protein
APT_02323	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
APT_02326	ENOG4105C6T	cysteine synthase
APT_02327	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
APT_02329	ENOG4107QNK	)-transporter
APT_02330	ENOG4105E4C	Lytic transglycosylase catalytic
APT_02331	ENOG4105DAA	L-lactate
APT_02334	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
APT_02336	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
APT_02341	ENOG4105KK4	UPF0060 membrane protein
APT_02344	ENOG4105CIH	Imidazole acetol-phosphate transaminase
APT_02347	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
APT_02348	ENOG4108J5G	6-phosphogluconate dehydrogenase
APT_02349	ENOG4108AZI	Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity)
APT_02350	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
APT_02351	ENOG4105E66	phosphoriboisomerase A
APT_02352	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
APT_02356	ENOG4105CMQ	Chloride channel
APT_02357	ENOG4105CPQ	Dehydrogenase
APT_02358	ENOG4105DFA	alanine racemase domain protein
APT_02359	ENOG4105DFH	Transport of potassium into the cell (By similarity)
APT_02360	ENOG4105CSA	Coproporphyrinogen iii oxidase
APT_02363	ENOG4108IV0	ABC, transporter
APT_02364	ENOG4105C0Z	ABC transporter
APT_02366	ENOG4105C32	Amino acid ABC transporter (Permease)
APT_02368	ENOG4105BZU	Histidine kinase
APT_02369	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
APT_02372	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
APT_02373	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
APT_02374	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
APT_02375	ENOG4105CQM	Urea amidohydrolase subunit alpha
APT_02376	ENOG4105KI2	Urea amidohydrolase subunit beta
APT_02377	ENOG4108YZ9	Urea amidohydrolase subunit gamma
APT_02378	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
APT_02384	ENOG4108UQY	Iron-storage protein
APT_02385	ENOG4105KUZ	arsenate reductase
APT_02387	ENOG4108R3E	Dna-3-methyladenine glycosylase i
APT_02388	ENOG41080HT	Transcriptional regulator, arsr family
APT_02389	ENOG4105D3R	alkyl hydroperoxide reductase
APT_02400	ENOG4105CSP	Major Facilitator Superfamily
APT_02401	ENOG4105RE0	Asp Glu hydantoin racemase
APT_02403	ENOG4108UAU	isochorismatase
APT_02405	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
APT_02406	ENOG4108XHQ	(2Fe-2S)-binding domain protein
APT_02407	ENOG4105MSY	salicylate hydroxylase
APT_02408	ENOG4108VHT	MarR family transcriptional regulator
APT_02412	ENOG4105C5X	domain protein
APT_02414	ENOG4105XRQ	Xanthine dehydrogenase accessory factor
APT_02418	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APT_02419	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
APT_02420	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
APT_02422	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
APT_02423	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
APT_02425	ENOG4105EXG	Transcriptional regulator
APT_02426	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
APT_02427	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
APT_02428	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
APT_02431	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
APT_02432	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
APT_02433	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
APT_02435	ENOG4105DHJ	ABC, transporter
APT_02436	ENOG4105DY2	Paraquat-inducible protein b
APT_02445	ENOG4105C3R	Methionine synthase
APT_02448	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
APT_02450	ENOG4105DY2	Paraquat-inducible protein b
APT_02451	ENOG4105F1S	paraquat-inducible protein a
APT_02452	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
APT_02453	ENOG4105CKK	Glycosyl transferase, family 2
APT_02458	ENOG4107PQ6	Inherit from NOG: atp synthase
APT_02460	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
APT_02461	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
APT_02462	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
APT_02465	ENOG4105C1J	atp-dependent rna helicase
APT_02468	ENOG4108UJD	30S ribosomal protein S9
APT_02469	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
APT_02473	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
APT_02474	ENOG4105E2Z	phosphate ABC transporter (Permease
APT_02475	ENOG4105C8U	phosphate abc transporter
APT_02476	ENOG4105C01	Dihydroxy-acid dehydratase
APT_02479	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
APT_02485	ENOG4105D1F	ATP-binding protein
APT_02488	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
APT_02490	ENOG4107GFK	fumarate
APT_02491	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
APT_02494	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
APT_02495	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
APT_02497	ENOG4107ZGG	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
APT_02498	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
APT_02501	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
APT_02503	ENOG4106JDQ	ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB
APT_02505	ENOG4105EXG	Transcriptional regulator
APT_02507	ENOG4105CDA	abc transporter atp-binding protein
APT_02508	ENOG4107QM5	aconitate hydratase
APT_02509	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
APT_02510	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
APT_02512	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
APT_02513	ENOG4107U9T	Pfam:Ribonuclease_BN
APT_02515	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
APT_02516	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
APT_02517	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
APT_02518	ENOG4105C54	Major Facilitator superfamily
APT_02519	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
APT_02524	ENOG4105TW1	Carbohydrate-selective porin OprB
APT_02527	ENOG4105TW1	Carbohydrate-selective porin OprB
APT_02529	ENOG4108JPW	Aminotransferase
APT_02531	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
APT_02532	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
APT_02533	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
APT_02534	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
APT_02535	ENOG4108JJ7	ABC transporter
APT_02536	ENOG4105CSM	endonuclease III
APT_02537	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
APT_02538	ENOG4105CEN	a g-specific adenine glycosylase
APT_02542	ENOG4105TXM	Domain of unknown function (DUF3576)
APT_02543	ENOG4105C8T	Leucyl-tRNA synthetase
APT_02549	ENOG4105C10	Electron transfer flavoprotein
APT_02550	ENOG4105TPV	
APT_02551	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
APT_02553	ENOG4105D4P	Coproporphyrinogen iii oxidase
APT_02555	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
APT_02556	ENOG4105C0H	protease
APT_02557	ENOG4108Z6B	deaminase
APT_02559	ENOG4108Z86	Glutamine amidotransferase
APT_02560	ENOG4105FE9	pseudouridine synthase
APT_02561	ENOG4106H78	methyltransferase
APT_02562	ENOG4108UUM	single-stranded DNA-binding protein
APT_02564	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APT_02569	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
APT_02571	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
APT_02572	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
APT_02573	ENOG4108TGR	phosphatase
APT_02579	ENOG4108RT7	Glycosyl transferase, family 2
APT_02580	ENOG4105CNU	cell division protein FtsK
APT_02582	ENOG4105E2K	Glycosyl transferase (Group 1
APT_02584	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
APT_02586	ENOG4105C3J	Cysteine desulfurase
APT_02587	ENOG4105C3J	Cysteine desulfurase
APT_02589	ENOG4105DHZ	alpha beta
APT_02591	ENOG4105C8N	cysteinyl-tRNA synthetase
APT_02592	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
APT_02594	ENOG4105K63	Thioredoxin
APT_02597	ENOG4108E87	P-loop hydrolase UPF0079
APT_02598	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
APT_02599	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
APT_02601	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
APT_02602	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
APT_02604	ENOG4105KCK	Peptidoglycan-associated lipoprotein
APT_02605	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
APT_02607	ENOG4108ZZF	transport protein (ExbD)
APT_02608	ENOG4105E02	MotA TolQ exbB proton channel
APT_02609	ENOG4107YD3	Thioesterase
APT_02610	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
APT_02611	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
APT_02612	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
APT_02613	ENOG4105CDY	transcriptional regulatory protein
APT_02614	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
APT_02615	ENOG4105EIN	peptidylprolyl cis-trans isomerase
APT_02616	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
APT_02618	ENOG4105D8X	mechanosensitive ion channel
APT_02622	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
APT_02626	ENOG4105II7	pyrroline-5-carboxylate reductase
APT_02629	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
APT_02633	ENOG4107S6X	Glycosyl transferase, family 2
APT_02635	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
APT_02636	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
APT_02637	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
APT_02638	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
APT_02639	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
APT_02640	ENOG4105K59	histidine triad (HIT) protein
APT_02641	ENOG41069NU	Nitroreductase
APT_02643	ENOG4105M0C	cytoplasmic protein
APT_02647	ENOG4105FA0	parb-like partition protein
APT_02648	ENOG4107QJE	Chromosome Partitioning Protein
APT_02649	ENOG4107YTN	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity)
APT_02650	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
APT_02651	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
APT_02652	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
APT_02656	ENOG4108URH	decarboxylase
APT_02659	ENOG4108YXA	Membrane
APT_02660	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
APT_02661	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
APT_02662	ENOG4108UHJ	MAF-like protein
APT_10005	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
APT_10019	ENOG4108UUM	single-stranded DNA-binding protein
APT_10023	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
APT_10041	ENOG4105N14	lysine exporter protein LysE YggA
APT_10047	ENOG4108C33	Resolvase
APT_10056	ENOG4108R8Z	these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
APT_10067	ENOG4105DQ6	Transposase
APT_10075	ENOG4105C22	threonyL-tRNA synthetase
APT_10076	ENOG4105MYN	Zinc uptake regulation protein
APT_10078	ENOG4105EUJ	GTP cyclohydrolase i
APT_10079	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
APT_10080	ENOG4105CKI	cobalamin synthesis protein
APT_10084	ENOG4105MZU	cell filamentation protein
APT_10095	ENOG4105ESI	atpase involved in dna repair
APT_10097	ENOG4108R3E	Dna-3-methyladenine glycosylase i
APT_10098	ENOG4105CF1	Alkylated DNA repair protein
APT_10101	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
APT_10104	ENOG4105EQ2	LysR family Transcriptional regulator
APT_10105	ENOG4105CPC	Aldo Keto reductase
APT_10110	ENOG4105C4W	S-formylglutathione hydrolase
APT_10116	ENOG4107DB1	DUF218 domain
APT_10124	ENOG4108Z40	Transcriptional regulator
APT_10126	ENOG4105ECQ	AraC Family Transcriptional Regulator
APT_10127	ENOG4105EMU	Dehydrogenase
APT_10134	ENOG4105MP0	transposase
APT_10137	ENOG4105DZ2	Transcriptional regulator
APT_10154	ENOG4108R8Z	these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
APT_10156	ENOG4105F7P	transcriptional regulator AsnC family
APT_10158	ENOG4106NZI	LysR family Transcriptional regulator
APT_10159	ENOG4107TT2	Auxin Efflux Carrier
APT_10160	ENOG4105CBN	LysR family transcriptional regulator
APT_10162	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
APT_10163	ENOG4105H3G	oxidoreductase
APT_10165	ENOG4108TJN	glycosyl transferase group 1
APT_10171	ENOG4107SQD	Transcriptional regulator, GntR family
APT_10173	ENOG4106NZI	LysR family Transcriptional regulator
APT_10176	ENOG4105CT4	transporter
APT_10177	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
APT_10178	ENOG4105EMU	Dehydrogenase
APT_10179	ENOG4105E7U	AraC family transcriptional regulator
APT_10187	ENOG4105F6U	Short-chain dehydrogenase reductase Sdr
APT_10189	ENOG4105CHR	reductase
APT_10192	ENOG4105C4R	Atp-dependent dna helicase
APT_10194	ENOG4107F83	nucleotidyltransferase DNA polymerase involved in DNA
APT_10195	ENOG4105C0B	DNA polymerase III (alpha subunit)
APT_10196	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
APT_10197	ENOG4108ZNX	Heat shock protein
APT_10201	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
APT_20002	ENOG4105MP0	transposase