locus-tag	class	description
APT_00001	COG1671	Belongs to the UPF0178 family
APT_00003	COG2814	Major facilitator Superfamily
APT_00005	COG2835	tetraacyldisaccharide 4'-kinase activity
APT_00006	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APT_00014	COG0778	Nitroreductase
APT_00016	COG0456	acetyltransferase
APT_00020	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APT_00021	COG1012	belongs to the aldehyde dehydrogenase family
APT_00023	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APT_00024	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APT_00025	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APT_00026	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APT_00028	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
APT_00030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APT_00033	COG0126	phosphoglycerate kinase activity
APT_00035	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APT_00037	COG0156	8-amino-7-oxononanoate synthase activity
APT_00038	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APT_00039	COG0405	Gamma-glutamyltransferase
APT_00043	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
APT_00045	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APT_00049	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APT_00050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APT_00052	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APT_00054	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APT_00055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APT_00056	COG0539	negative regulation of cytoplasmic translation
APT_00059	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APT_00060	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APT_00061	COG1420	regulation of RNA biosynthetic process
APT_00062	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APT_00069	COG0772	Belongs to the SEDS family
APT_00070	COG0768	penicillin binding
APT_00074	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT_00075	COG1612	heme a metabolic process
APT_00077	COG2814	Major facilitator Superfamily
APT_00079	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APT_00080	COG1289	transmembrane transporter activity
APT_00082	COG1573	uracil-dna glycosylase
APT_00086	COG0670	Belongs to the BI1 family
APT_00090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APT_00093	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APT_00096	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APT_00100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APT_00105	COG1028	Short-chain dehydrogenase reductase Sdr
APT_00106	COG0586	Pfam SNARE associated Golgi protein
APT_00108	COG0281	malic enzyme
APT_00111	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APT_00112	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APT_00113	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APT_00114	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APT_00115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APT_00116	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APT_00117	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APT_00118	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APT_00121	COG1113	amino acid transport
APT_00122	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APT_00123	COG4208	sulfate ABC transporter
APT_00127	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APT_00128	COG2207	Transcriptional regulator
APT_00129	COG4303	Ethanolamine ammonia lyase large subunit
APT_00130	COG4302	ethanolamine ammonia-lyase activity
APT_00133	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT_00135	COG1538	Outer membrane efflux protein
APT_00136	COG1278	Cold shock
APT_00143	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APT_00145	COG2205	protein histidine kinase activity
APT_00145	COG0784	Response regulator, receiver
APT_00149	COG0411	ABC transporter
APT_00150	COG1137	ATPase activity
APT_00164	COG2983	Belongs to the UPF0260 family
APT_00167	COG3842	ATPase activity
APT_00172	COG1566	PFAM secretion protein HlyD family protein
APT_00176	COG1657	PFAM Prenyltransferase squalene oxidase
APT_00177	COG1233	COG1233 Phytoene dehydrogenase and related
APT_00178	COG1562	ergosterol biosynthetic process
APT_00179	COG1562	ergosterol biosynthetic process
APT_00181	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT_00183	COG0287	Prephenate dehydrogenase
APT_00185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APT_00187	COG0450	alkyl hydroperoxide reductase
APT_00188	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT_00190	COG3384	dioxygenase
APT_00191	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APT_00192	COG0488	(ABC) transporter
APT_00196	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APT_00199	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APT_00200	COG0343	queuine tRNA-ribosyltransferase activity
APT_00201	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APT_00203	COG1881	PFAM PEBP family protein
APT_00206	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APT_00209	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APT_00214	COG1877	trehalose-phosphatase activity
APT_00215	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
APT_00216	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APT_00218	COG0494	nUDIX hydrolase
APT_00219	COG0667	Aldo Keto reductase
APT_00221	COG0556	nucleotide-excision repair
APT_00223	COG0612	Peptidase, M16
APT_00230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APT_00233	COG0167	dihydroorotate dehydrogenase activity
APT_00236	COG1692	metallophosphoesterase
APT_00237	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APT_00242	COG0352	thiamine-phosphate diphosphorylase activity
APT_00247	COG1509	lysine 2,3-aminomutase activity
APT_00249	COG0024	Methionine aminopeptidase
APT_00250	COG1686	Belongs to the peptidase S11 family
APT_00251	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APT_00254	COG2326	polyphosphate kinase activity
APT_00255	COG1678	Uncharacterized ACR, COG1678
APT_00256	COG1660	Displays ATPase and GTPase activities
APT_00258	COG2205	protein histidine kinase activity
APT_00259	COG0745	RESPONSE REGULATOR receiver
APT_00260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APT_00261	COG0443	Heat shock 70 kDa protein
APT_00262	COG0484	heat shock protein binding
APT_00263	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APT_00264	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APT_00265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APT_00266	COG0138	bifunctional purine biosynthesis protein purh
APT_00269	COG0697	spore germination
APT_00271	COG0752	glycyl-tRNA synthetase alpha subunit
APT_00273	COG1396	sequence-specific DNA binding
APT_00274	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APT_00278	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APT_00280	COG0598	Magnesium transport protein CorA
APT_00281	COG0133	tryptophan synthase activity
APT_00282	COG0159	tryptophan synthase activity
APT_00283	COG1053	succinate dehydrogenase
APT_00283	COG0431	NADPH-dependent FMN reductase
APT_00283	COG3976	FMN-binding domain protein
APT_00285	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APT_00286	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APT_00287	COG0745	RESPONSE REGULATOR receiver
APT_00289	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APT_00294	COG1253	flavin adenine dinucleotide binding
APT_00295	COG0604	alcohol dehydrogenase
APT_00297	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT_00300	COG1028	Short-chain dehydrogenase reductase Sdr
APT_00301	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APT_00302	COG3956	TIGRFAM MazG family protein
APT_00304	COG0326	Molecular chaperone. Has ATPase activity
APT_00318	COG2755	lipolytic protein G-D-S-L family
APT_00318	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APT_00324	COG2079	MmgE PrpD family protein
APT_00325	COG0372	Belongs to the citrate synthase family
APT_00326	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
APT_00327	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APT_00328	COG2814	Major facilitator Superfamily
APT_00329	COG2319	Wd-40 repeat
APT_00331	COG2309	aminopeptidase activity
APT_00334	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APT_00336	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APT_00337	COG0193	aminoacyl-tRNA hydrolase activity
APT_00338	COG0012	GTP binding
APT_00339	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APT_00340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APT_00341	COG0799	negative regulation of ribosome biogenesis
APT_00342	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APT_00349	COG0247	lactate metabolic process
APT_00350	COG1139	Iron-sulfur cluster binding protein
APT_00352	COG0697	spore germination
APT_00353	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APT_00354	COG0717	Belongs to the dCTP deaminase family
APT_00358	COG3394	polysaccharide catabolic process
APT_00362	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APT_00363	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APT_00364	COG1253	flavin adenine dinucleotide binding
APT_00365	COG0741	lytic transglycosylase activity
APT_00366	COG1573	uracil-dna glycosylase
APT_00368	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APT_00377	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APT_00386	COG1028	Short-chain dehydrogenase reductase Sdr
APT_00389	COG0025	NhaP-type Na H and K H
APT_00391	COG4771	TonB-dependent receptor
APT_00393	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT_00394	COG1120	ATPase activity
APT_00395	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APT_00396	COG2971	BadF BadG BcrA BcrD
APT_00397	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APT_00403	COG0415	Belongs to the DNA photolyase family
APT_00404	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT_00410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APT_00425	COG1012	belongs to the aldehyde dehydrogenase family
APT_00455	COG4774	siderophore transport
APT_00476	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APT_00476	COG2755	lipolytic protein G-D-S-L family
APT_00513	COG1959	2 iron, 2 sulfur cluster binding
APT_00514	COG4221	oxidoreductase activity
APT_00515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APT_00519	COG1607	acyl-coa hydrolase
APT_00524	COG1309	transcriptional regulator
APT_00527	COG1960	acyl-CoA dehydrogenase activity
APT_00528	COG1028	Short-chain dehydrogenase reductase Sdr
APT_00533	COG1012	belongs to the aldehyde dehydrogenase family
APT_00540	COG0306	phosphate transporter
APT_00542	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APT_00543	COG0022	dehydrogenase e1 component
APT_00545	COG0071	Belongs to the small heat shock protein (HSP20) family
APT_00547	COG1252	NADH dehydrogenase
APT_00549	COG0523	cobalamin synthesis protein
APT_00551	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APT_00552	COG1230	cation diffusion facilitator family transporter
APT_00553	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
APT_00554	COG0596	Alpha beta hydrolase
APT_00557	COG1297	OPT oligopeptide transporter protein
APT_00563	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APT_00565	COG0469	pyruvate kinase activity
APT_00573	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT_00574	COG0492	ferredoxin-NADP+ reductase activity
APT_00575	COG0538	isocitrate dehydrogenase activity
APT_00581	COG4993	Dehydrogenase
APT_00584	COG0481	GTPase activity
APT_00585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT_00586	COG2813	Specifically methylates the guanine in position
APT_00586	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT_00587	COG0513	Belongs to the DEAD box helicase family
APT_00591	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APT_00592	COG1758	RNA polymerase activity
APT_00593	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APT_00594	COG0736	holo-[acyl-carrier-protein] synthase activity
APT_00595	COG0681	Belongs to the peptidase S26 family
APT_00596	COG0571	ribonuclease III activity
APT_00597	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APT_00598	COG0528	UMP kinase activity
APT_00599	COG0233	cytoplasmic translational termination
APT_00600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APT_00602	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APT_00603	COG0750	zinc metalloprotease
APT_00606	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT_00607	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APT_00608	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT_00609	COG3494	Protein of unknown function (DUF1009)
APT_00610	COG0346	lactoylglutathione lyase activity
APT_00612	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APT_00613	COG0594	ribonuclease P activity
APT_00614	COG0706	membrane insertase activity
APT_00615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APT_00616	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APT_00617	COG2171	N-acyltransferase activity
APT_00618	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT_00620	COG0101	tRNA pseudouridine synthase activity
APT_00621	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APT_00622	COG0242	peptide deformylase activity
APT_00625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APT_00627	COG3217	Mosc domain protein beta barrel domain protein
APT_00627	COG0633	Ferredoxin
APT_00628	COG1137	ATPase activity
APT_00631	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APT_00631	COG0517	IMP dehydrogenase activity
APT_00633	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APT_00635	COG4221	oxidoreductase activity
APT_00636	COG0194	GDP metabolic process
APT_00637	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APT_00637	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APT_00638	COG2942	2-epimerase
APT_00639	COG0305	Participates in initiation and elongation during chromosome replication
APT_00641	COG3264	Mechanosensitive ion channel
APT_00641	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APT_00643	COG1127	ABC transporter
APT_00644	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APT_00650	COG1113	amino acid transport
APT_00652	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APT_00652	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APT_00652	COG0506	proline dehydrogenase activity
APT_00655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APT_00661	COG2096	Adenosyltransferase
APT_00666	COG0009	L-threonylcarbamoyladenylate synthase
APT_00668	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APT_00670	COG0656	L-ascorbic acid biosynthetic process
APT_00672	COG1643	Atp-dependent helicase
APT_00674	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APT_00677	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APT_00678	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APT_00681	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APT_00682	COG0235	Class ii aldolase
APT_00683	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
APT_00684	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
APT_00685	COG0196	riboflavin kinase activity
APT_00686	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APT_00687	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APT_00689	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APT_00691	COG5006	permease, DMT superfamily
APT_00693	COG0187	DNA topoisomerase II activity
APT_00696	COG1959	2 iron, 2 sulfur cluster binding
APT_00697	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APT_00698	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APT_00698	COG2885	chlorophyll binding
APT_00700	COG0793	Belongs to the peptidase S41A family
APT_00701	COG0557	exoribonuclease II activity
APT_00702	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APT_00703	COG0758	DNA mediated transformation
APT_00704	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APT_00705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APT_00706	COG0540	Belongs to the ATCase OTCase family
APT_00707	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT_00708	COG0658	competence protein
APT_00708	COG2333	competence protein COMEC
APT_00709	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT_00710	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APT_00712	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT_00716	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APT_00728	COG3260	NADH ubiquinone oxidoreductase 20
APT_00729	COG1183	phosphatidylcholine synthase activity
APT_00730	COG0688	phosphatidylethanolamine metabolic process
APT_00731	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APT_00733	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APT_00733	COG2885	chlorophyll binding
APT_00734	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APT_00736	COG4974	Belongs to the 'phage' integrase family
APT_00737	COG0825	malonyl-CoA metabolic process
APT_00738	COG1546	Belongs to the CinA family
APT_00738	COG1058	Belongs to the CinA family
APT_00739	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
APT_00742	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APT_00743	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APT_00744	COG0181	hydroxymethylbilane synthase activity
APT_00746	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APT_00747	COG0406	alpha-ribazole phosphatase activity
APT_00749	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APT_00753	COG0408	coproporphyrinogen oxidase activity
APT_00754	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APT_00754	COG2857	Cytochrome c1
APT_00755	COG2857	Cytochrome c1
APT_00755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APT_00756	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APT_00760	COG0778	Nitroreductase
APT_00773	COG0582	viral genome integration into host DNA
APT_00803	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APT_00804	COG1902	pentaerythritol trinitrate reductase activity
APT_00805	COG0640	Transcriptional regulator
APT_00807	COG3591	Belongs to the peptidase S1B family
APT_00808	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APT_00810	COG0019	diaminopimelate decarboxylase activity
APT_00811	COG0165	Argininosuccinate lyase
APT_00814	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APT_00815	COG0237	dephospho-CoA kinase activity
APT_00816	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APT_00820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APT_00822	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APT_00823	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APT_00825	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APT_00826	COG0248	Ppx GppA phosphatase
APT_00829	COG1121	(ABC) transporter
APT_00834	COG1289	transmembrane transporter activity
APT_00835	COG1289	transmembrane transporter activity
APT_00839	COG3088	subunit of a heme lyase
APT_00840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT_00841	COG1138	Cytochrome C-type biogenesis protein
APT_00842	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
APT_00844	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APT_00852	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APT_00858	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APT_00860	COG0477	Major facilitator Superfamily
APT_00868	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APT_00869	COG0081	regulation of translation
APT_00870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APT_00871	COG0222	ribosome binding
APT_00872	COG0085	RNA polymerase activity
APT_00873	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APT_00874	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APT_00875	COG0049	tRNA binding
APT_00876	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APT_00877	COG0051	transcription antitermination factor activity, RNA binding
APT_00878	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APT_00879	COG0088	Forms part of the polypeptide exit tunnel
APT_00880	COG0089	rRNA binding
APT_00881	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APT_00882	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APT_00883	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APT_00884	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APT_00885	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APT_00886	COG0255	Belongs to the universal ribosomal protein uL29 family
APT_00887	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APT_00888	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APT_00889	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APT_00890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APT_00891	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APT_00892	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APT_00893	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APT_00894	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APT_00895	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APT_00896	COG1841	ribosomal large subunit assembly
APT_00897	COG0200	Binds to the 23S rRNA
APT_00899	COG0563	adenylate kinase activity
APT_00900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APT_00901	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APT_00902	COG0202	RNA polymerase activity
APT_00903	COG0203	ribosomal protein L17
APT_00905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT_00906	COG1116	anion transmembrane transporter activity
APT_00908	COG5487	UPF0391 membrane protein
APT_00909	COG1538	Outer membrane efflux protein
APT_00911	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT_00912	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT_00913	COG0477	Major facilitator Superfamily
APT_00914	COG3237	CsbD-like
APT_00915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APT_00916	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APT_00921	COG0714	Associated with various cellular activities
APT_00923	COG0617	tRNA 3'-terminal CCA addition
APT_00924	COG1132	(ABC) transporter
APT_00926	COG2814	Major facilitator Superfamily
APT_00927	COG1051	belongs to the nudix hydrolase family
APT_00929	COG0793	Belongs to the peptidase S41A family
APT_00931	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APT_00932	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APT_00933	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APT_00934	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APT_00935	COG0505	Belongs to the CarA family
APT_00937	COG0358	DNA primase activity
APT_00938	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT_00940	COG0360	Binds together with S18 to 16S ribosomal RNA
APT_00941	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APT_00942	COG0359	binds to the 23S rRNA
APT_00943	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APT_00944	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APT_00946	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APT_00950	COG1132	(ABC) transporter
APT_00951	COG1802	Transcriptional regulator
APT_00952	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
APT_00954	COG0850	regulation of cytokinetic process
APT_00956	COG2081	HI0933 family
APT_00957	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APT_00959	COG0859	PFAM glycosyl transferase family 9
APT_00959	COG0457	Tetratricopeptide repeat
APT_00960	COG1329	Transcriptional regulator
APT_00961	COG3781	membrane
APT_00962	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
APT_00965	COG2884	Cell division ATP-binding protein ftsE
APT_00970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APT_00971	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APT_00975	COG2010	Cytochrome c
APT_00975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APT_00976	COG0246	Mannitol dehydrogenase
APT_00977	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APT_00978	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APT_00979	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APT_00980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT_00980	COG0072	phenylalanine-tRNA ligase activity
APT_00982	COG0747	negative chemotaxis
APT_00986	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APT_00987	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APT_00989	COG0473	3-isopropylmalate dehydrogenase activity
APT_00990	COG0006	proline dipeptidase activity
APT_00991	COG2264	protein methyltransferase activity
APT_00993	COG2003	Belongs to the UPF0758 family
APT_00994	COG2003	Belongs to the UPF0758 family
APT_00995	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APT_00996	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APT_01000	COG0071	Belongs to the small heat shock protein (HSP20) family
APT_01002	COG0254	rRNA binding
APT_01004	COG1970	mechanosensitive ion channel activity
APT_01006	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT_01007	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT_01009	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APT_01009	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APT_01010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APT_01012	COG0142	geranyltranstransferase activity
APT_01013	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APT_01014	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APT_01017	COG2062	phosphohistidine phosphatase, SixA
APT_01018	COG1605	Chorismate mutase
APT_01018	COG0287	Prephenate dehydrogenase
APT_01023	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APT_01025	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APT_01027	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APT_01029	COG0729	surface antigen
APT_01033	COG0322	excinuclease ABC activity
APT_01036	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APT_01037	COG0314	molybdopterin synthase activity
APT_01038	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APT_01039	COG0156	8-amino-7-oxononanoate synthase activity
APT_01041	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APT_01041	COG4106	trans-aconitate 2-methyltransferase activity
APT_01042	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APT_01044	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APT_01046	COG0148	phosphopyruvate hydratase activity
APT_01050	COG2022	thiamine diphosphate biosynthetic process
APT_01053	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APT_01054	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APT_01056	COG0385	Bile acid
APT_01057	COG0076	glutamate decarboxylase activity
APT_01060	COG0484	heat shock protein binding
APT_01061	COG0271	Belongs to the BolA IbaG family
APT_01063	COG0321	lipoyl(octanoyl) transferase activity
APT_01066	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APT_01067	COG2226	methyltransferase
APT_01068	COG1040	competence protein
APT_01072	COG2706	6-phosphogluconolactonase activity
APT_01073	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT_01074	COG0527	aspartate kinase activity
APT_01075	COG2070	2-Nitropropane dioxygenase
APT_01077	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APT_01078	COG0124	histidyl-tRNA synthetase
APT_01079	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APT_01081	COG2890	protein-(glutamine-N5) methyltransferase activity
APT_01084	COG1968	undecaprenyl-diphosphatase activity
APT_01085	COG0531	amino acid
APT_01088	COG2951	lytic endotransglycosylase activity
APT_01089	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APT_01090	COG1686	Belongs to the peptidase S11 family
APT_01091	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APT_01094	COG0084	hydrolase, TatD family'
APT_01097	COG0259	pyridoxamine-phosphate oxidase activity
APT_01098	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APT_01099	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APT_01100	COG1764	response to oxidative stress
APT_01101	COG0579	oxidoreductase
APT_01103	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APT_01104	COG0602	queuosine metabolic process
APT_01105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APT_01107	COG0175	sulfate reduction
APT_01108	COG0175	sulfate reduction
APT_01111	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APT_01113	COG1519	Transferase
APT_01114	COG1663	tetraacyldisaccharide 4'-kinase activity
APT_01118	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APT_01119	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT_01120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APT_01123	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APT_01129	COG1278	Cold shock
APT_01130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APT_01131	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT_01132	COG0077	Prephenate dehydratase
APT_01132	COG1605	Chorismate mutase
APT_01133	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APT_01134	COG3474	cytochrome
APT_01136	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT_01137	COG0606	chelatase, subunit chli
APT_01138	COG0626	cystathionine gamma-synthase activity
APT_01139	COG2897	thiosulfate sulfurtransferase activity
APT_01140	COG0628	permease
APT_01143	COG0792	nuclease activity
APT_01145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APT_01146	COG0271	Belongs to the BolA IbaG family
APT_01147	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APT_01148	COG0047	phosphoribosylformylglycinamidine synthase activity
APT_01150	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APT_01151	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APT_01152	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APT_01153	COG0861	Integral membrane protein TerC family
APT_01156	COG1546	Belongs to the CinA family
APT_01160	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APT_01161	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT_01162	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT_01163	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT_01163	COG0022	dehydrogenase e1 component
APT_01164	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APT_01165	COG0315	cyclic pyranopterin monophosphate synthase activity
APT_01166	COG0134	indole-3-glycerol-phosphate synthase activity
APT_01167	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APT_01169	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APT_01171	COG0149	triose-phosphate isomerase activity
APT_01173	COG0504	CTP synthase activity
APT_01174	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APT_01175	COG0187	DNA topoisomerase II activity
APT_01176	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APT_01177	COG0592	DNA-directed DNA polymerase activity
APT_01178	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APT_01180	COG0268	Binds directly to 16S ribosomal RNA
APT_01181	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APT_01182	COG2226	methyltransferase
APT_01183	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APT_01184	COG0756	dUTP diphosphatase activity
APT_01185	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT_01186	COG1116	anion transmembrane transporter activity
APT_01187	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT_01188	COG0525	valine-tRNA ligase activity
APT_01191	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APT_01192	COG0582	viral genome integration into host DNA
APT_01225	COG1028	Short-chain dehydrogenase reductase Sdr
APT_01226	COG0456	acetyltransferase
APT_01227	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APT_01228	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT_01229	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APT_01232	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APT_01233	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APT_01235	COG1349	DNA-binding transcription factor activity
APT_01238	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APT_01239	COG4988	ABC transporter
APT_01244	COG0784	Response regulator, receiver
APT_01248	COG2824	Alkylphosphonate utilization operon protein PhnA
APT_01249	COG0814	amino acid
APT_01251	COG0384	phenazine biosynthesis protein PhzF
APT_01255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT_01255	COG1116	anion transmembrane transporter activity
APT_01261	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
APT_01266	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APT_01268	COG2233	PERMEase
APT_01269	COG2351	hydroxyisourate hydrolase activity
APT_01272	COG2072	flavoprotein involved in K transport
APT_01274	COG0402	S-adenosylhomocysteine deaminase activity
APT_01281	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT_01282	COG1129	ABC transporter
APT_01282	COG0842	Transport permease protein
APT_01283	COG0842	Transport permease protein
APT_01286	COG2855	membrane
APT_01288	COG1657	PFAM Prenyltransferase squalene oxidase
APT_01292	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APT_01293	COG1012	belongs to the aldehyde dehydrogenase family
APT_01294	COG1902	pentaerythritol trinitrate reductase activity
APT_01295	COG1733	regulation of RNA biosynthetic process
APT_01296	COG0753	catalase activity
APT_01299	COG3459	Glycosyltransferase 36 associated
APT_01306	COG4178	(ABC) transporter
APT_01322	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APT_01323	COG0477	Major facilitator Superfamily
APT_01326	COG0848	biopolymer transport protein
APT_01330	COG4774	siderophore transport
APT_01332	COG1595	DNA-templated transcription, initiation
APT_01333	COG4774	siderophore transport
APT_01335	COG1191	sigma factor activity
APT_01336	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT_01337	COG1116	anion transmembrane transporter activity
APT_01338	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT_01340	COG2175	clavaminate synthase activity
APT_01344	COG2271	Major facilitator Superfamily
APT_01345	COG0583	DNA-binding transcription factor activity
APT_01350	COG1454	alcohol dehydrogenase
APT_01354	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT_01355	COG1116	anion transmembrane transporter activity
APT_01356	COG0864	Transcriptional regulator
APT_01358	COG3665	Urea carboxylase-associated protein
APT_01367	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
APT_01368	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT_01369	COG4558	Periplasmic binding protein
APT_01371	COG1321	iron dependent repressor
APT_01372	COG1914	H( )-stimulated, divalent metal cation uptake system
APT_01377	COG0596	Alpha beta hydrolase
APT_01378	COG0004	ammonium transporteR
APT_01383	COG0523	cobalamin synthesis protein
APT_01384	COG1902	pentaerythritol trinitrate reductase activity
APT_01385	COG4221	oxidoreductase activity
APT_01386	COG1917	Cupin 2, conserved barrel domain protein
APT_01386	COG4977	sequence-specific DNA binding
APT_01387	COG1408	metallophosphoesterase
APT_01389	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APT_01398	COG2211	Major facilitator Superfamily
APT_01403	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT_01406	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT_01412	COG4774	siderophore transport
APT_01415	COG0732	type I restriction modification DNA specificity domain
APT_01416	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APT_01422	COG0318	PFAM AMP-dependent synthetase and ligase
APT_01429	COG2815	serine threonine protein kinase
APT_01429	COG0515	serine threonine protein kinase
APT_01432	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APT_01438	COG0741	lytic transglycosylase activity
APT_01446	COG1301	dicarboxylic acid transport
APT_01447	COG0500	methyltransferase
APT_01448	COG2999	glutathione oxidoreductase activity
APT_01449	COG2814	Major facilitator Superfamily
APT_01451	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
APT_01461	COG0114	fumarate hydratase activity
APT_01473	COG0628	permease
APT_01478	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APT_01478	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APT_01478	COG0674	pyruvate-flavodoxin oxidoreductase activity
APT_01478	COG1013	pyruvate-flavodoxin oxidoreductase activity
APT_01479	COG0493	'glutamate synthase
APT_01482	COG1971	Probably functions as a manganese efflux pump
APT_01484	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APT_01486	COG1763	Mo-molybdopterin cofactor biosynthetic process
APT_01487	COG0303	'Molybdopterin
APT_01488	COG3058	Necessary for formate dehydrogenase activity
APT_01489	COG2864	formate dehydrogenase
APT_01490	COG0437	4 iron, 4 sulfur cluster binding
APT_01491	COG3383	formate dehydrogenase (NAD+) activity
APT_01491	COG0243	molybdopterin cofactor binding
APT_01492	COG0248	Ppx GppA phosphatase
APT_01493	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APT_01494	COG1940	carbohydrate kinase activity
APT_01495	COG0425	Belongs to the sulfur carrier protein TusA family
APT_01496	COG1722	exodeoxyribonuclease VII activity
APT_01497	COG0142	geranyltranstransferase activity
APT_01498	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APT_01499	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
APT_01501	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APT_01502	COG0137	argininosuccinate synthase activity
APT_01503	COG0545	Peptidyl-prolyl cis-trans isomerase
APT_01505	COG0180	Tryptophanyl-tRNA synthetase
APT_01507	COG0745	RESPONSE REGULATOR receiver
APT_01510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APT_01510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT_01516	COG4608	Belongs to the ABC transporter superfamily
APT_01517	COG2070	2-Nitropropane dioxygenase
APT_01518	COG0671	phosphoesterase, PA-phosphatase related
APT_01521	COG3511	phospholipase C
APT_01526	COG0477	Major facilitator Superfamily
APT_01530	COG1695	Transcriptional regulator
APT_01533	COG1566	PFAM secretion protein HlyD family protein
APT_01534	COG1289	transmembrane transporter activity
APT_01536	COG1032	radical SAM domain protein
APT_01539	COG0668	transmembrane transport
APT_01543	COG1294	oxidase, subunit
APT_01544	COG1271	oxidase subunit
APT_01545	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APT_01546	COG4988	ABC transporter
APT_01548	COG3128	pkhd-type hydroxylase
APT_01549	COG4774	siderophore transport
APT_01553	COG0252	asparaginase activity
APT_01555	COG2985	domain, Protein
APT_01557	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT_01562	COG0488	(ABC) transporter
APT_01563	COG0583	DNA-binding transcription factor activity
APT_01566	COG1064	alcohol dehydrogenase
APT_01568	COG3685	Protein conserved in bacteria
APT_01570	COG1285	pathogenesis
APT_01574	COG0028	Belongs to the TPP enzyme family
APT_01577	COG1028	Short-chain dehydrogenase reductase Sdr
APT_01579	COG1028	Short-chain dehydrogenase reductase Sdr
APT_01582	COG2814	Major facilitator Superfamily
APT_01593	COG4774	siderophore transport
APT_01599	COG0642	Histidine kinase
APT_01617	COG2211	Major facilitator Superfamily
APT_01626	COG3293	Transposase
APT_01627	COG1204	response to ionizing radiation
APT_01643	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APT_01655	COG4977	sequence-specific DNA binding
APT_01659	COG0477	Major facilitator Superfamily
APT_01671	COG2963	transposase activity
APT_01672	COG2826	transposase and inactivated derivatives, IS30 family
APT_01684	COG1570	exodeoxyribonuclease VII activity
APT_01690	COG3551	Protein conserved in bacteria
APT_01703	COG0318	PFAM AMP-dependent synthetase and ligase
APT_01705	COG0156	8-amino-7-oxononanoate synthase activity
APT_01708	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APT_01713	COG0546	phosphoglycolate phosphatase activity
APT_01714	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APT_01715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APT_01718	COG0386	Belongs to the glutathione peroxidase family
APT_01719	COG1136	(ABC) transporter
APT_01721	COG0442	prolyl-tRNA aminoacylation
APT_01723	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APT_01725	COG1007	ATP synthesis coupled electron transport
APT_01727	COG0713	ATP synthesis coupled electron transport
APT_01729	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT_01730	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APT_01731	COG1034	ATP synthesis coupled electron transport
APT_01733	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APT_01734	COG0649	NAD binding
APT_01735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT_01736	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT_01738	COG0776	regulation of translation
APT_01740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APT_01741	COG0740	serine-type endopeptidase activity
APT_01742	COG0544	peptidyl-prolyl cis-trans isomerase activity
APT_01743	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APT_01743	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APT_01745	COG0513	Belongs to the DEAD box helicase family
APT_01746	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APT_01747	COG0316	Belongs to the HesB IscA family
APT_01748	COG2151	metal-sulfur cluster biosynthetic enzyme
APT_01750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APT_01751	COG0719	Fe-S assembly protein
APT_01752	COG0396	ATPase activity
APT_01753	COG0719	Fe-S assembly protein
APT_01755	COG2733	membrane
APT_01756	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APT_01758	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APT_01759	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APT_01761	COG5265	(ABC) transporter
APT_01763	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
APT_01764	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APT_01769	COG0612	Peptidase, M16
APT_01770	COG0312	modulator of DNA gyrase
APT_01774	COG0109	protoheme IX farnesyltransferase activity
APT_01777	COG2226	methyltransferase
APT_01782	COG1522	sequence-specific DNA binding
APT_01783	COG0492	ferredoxin-NADP+ reductase activity
APT_01784	COG0583	DNA-binding transcription factor activity
APT_01786	COG0776	regulation of translation
APT_01791	COG0776	regulation of translation
APT_01792	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APT_01793	COG0416	fatty acid biosynthetic process
APT_01794	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APT_01797	COG2205	protein histidine kinase activity
APT_01798	COG0745	RESPONSE REGULATOR receiver
APT_01799	COG1846	Transcriptional regulator
APT_01801	COG0242	peptide deformylase activity
APT_01802	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APT_01803	COG0473	3-isopropylmalate dehydrogenase activity
APT_01804	COG0066	3-isopropylmalate dehydratase activity
APT_01805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APT_01806	COG0335	large ribosomal subunit rRNA binding
APT_01807	COG0336	Belongs to the RNA methyltransferase TrmD family
APT_01808	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APT_01809	COG0228	four-way junction DNA binding
APT_01814	COG0564	pseudouridine synthase activity
APT_01815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APT_01819	COG3572	ergothioneine biosynthetic process
APT_01820	COG2814	Major facilitator Superfamily
APT_01822	COG1160	GTP binding
APT_01827	COG0438	transferase activity, transferring glycosyl groups
APT_01828	COG0367	asparagine synthase
APT_01830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APT_01831	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT_01832	COG0659	secondary active sulfate transmembrane transporter activity
APT_01836	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APT_01838	COG1051	belongs to the nudix hydrolase family
APT_01839	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APT_01840	COG1923	regulation of RNA biosynthetic process
APT_01841	COG2204	response regulator
APT_01846	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APT_01846	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APT_01847	COG0463	Glycosyl transferase, family 2
APT_01853	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APT_01855	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APT_01857	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APT_01860	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
APT_01862	COG0347	Belongs to the P(II) protein family
APT_01864	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT_01865	COG0586	Pfam SNARE associated Golgi protein
APT_01872	COG3547	Transposase (IS116 IS110 IS902 family)
APT_01873	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APT_01874	COG0483	inositol monophosphate 1-phosphatase activity
APT_01875	COG1199	ATP-dependent helicase activity
APT_01876	COG1278	Cold shock
APT_01877	COG0412	Dienelactone hydrolase
APT_01878	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APT_01879	COG0459	protein refolding
APT_01891	COG0004	ammonium transporteR
APT_01895	COG4974	Belongs to the 'phage' integrase family
APT_01900	COG0494	nUDIX hydrolase
APT_01903	COG2967	ApaG domain
APT_01904	COG0302	gtp cyclohydrolase
APT_01906	COG0521	Mo-molybdopterin cofactor biosynthetic process
APT_01913	COG1566	PFAM secretion protein HlyD family protein
APT_01919	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APT_01920	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APT_01920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APT_01921	COG0307	riboflavin synthase, alpha
APT_01924	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APT_01924	COG2857	Cytochrome c1
APT_01925	COG2857	Cytochrome c1
APT_01925	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APT_01926	COG0723	plastoquinol--plastocyanin reductase activity
APT_01930	COG2252	PERMEase
APT_01935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APT_01936	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APT_01937	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APT_01938	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APT_01940	COG3750	Belongs to the UPF0335 family
APT_01941	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APT_01945	COG2001	Belongs to the MraZ family
APT_01946	COG0275	rRNA processing
APT_01949	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APT_01951	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APT_01952	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APT_01954	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APT_01955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APT_01956	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APT_01957	COG1181	Belongs to the D-alanine--D-alanine ligase family
APT_01958	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APT_01959	COG0849	cell division
APT_01961	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APT_01962	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APT_01963	COG0497	DNA recombination
APT_01964	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APT_01965	COG0574	Belongs to the PEP-utilizing enzyme family
APT_01965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APT_01966	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
APT_01970	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
APT_01973	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT_01974	COG1335	isochorismatase
APT_01978	COG2132	Multicopper oxidase
APT_01980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APT_01982	COG0028	Belongs to the TPP enzyme family
APT_01983	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APT_01984	COG3830	Belongs to the UPF0237 family
APT_01984	COG0560	Phosphoserine phosphatase
APT_01987	COG0513	Belongs to the DEAD box helicase family
APT_01991	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APT_01993	COG0531	amino acid
APT_01994	COG0113	porphobilinogen synthase activity
APT_01995	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
APT_01996	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APT_01997	COG1381	Involved in DNA repair and RecF pathway recombination
APT_01998	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APT_01999	COG0052	Belongs to the universal ribosomal protein uS2 family
APT_02003	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APT_02004	COG0587	DNA-directed DNA polymerase activity
APT_02005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APT_02006	COG0251	oxidation-reduction process
APT_02010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT_02014	COG3161	chorismate lyase activity
APT_02015	COG1032	radical SAM domain protein
APT_02016	COG0105	UTP biosynthetic process
APT_02017	COG0488	(ABC) transporter
APT_02019	COG0745	RESPONSE REGULATOR receiver
APT_02020	COG0642	Histidine kinase
APT_02020	COG3850	Histidine kinase
APT_02022	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APT_02023	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APT_02027	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APT_02030	COG0328	RNA-DNA hybrid ribonuclease activity
APT_02031	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
APT_02032	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APT_02041	COG0860	N-Acetylmuramoyl-L-alanine amidase
APT_02042	COG1530	ribonuclease E activity
APT_02043	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APT_02044	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APT_02045	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APT_02046	COG0424	maF-like protein
APT_02048	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
APT_02094	COG3750	Belongs to the UPF0335 family
APT_02102	COG0277	FAD linked oxidase domain protein
APT_02105	COG2308	Evidence 4 Homologs of previously reported genes of
APT_02110	COG1309	transcriptional regulator
APT_02111	COG1252	NADH dehydrogenase
APT_02112	COG1012	belongs to the aldehyde dehydrogenase family
APT_02114	COG2814	Major facilitator Superfamily
APT_02116	COG0431	NADPH-dependent FMN reductase
APT_02118	COG0583	DNA-binding transcription factor activity
APT_02126	COG0697	spore germination
APT_02127	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
APT_02128	COG1984	allophanate hydrolase subunit 2
APT_02130	COG4221	oxidoreductase activity
APT_02137	COG0300	oxidoreductase activity
APT_02139	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APT_02140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APT_02141	COG0297	glycogen (starch) synthase activity
APT_02144	COG1028	Short-chain dehydrogenase reductase Sdr
APT_02145	COG0028	Belongs to the TPP enzyme family
APT_02147	COG1999	signal sequence binding
APT_02158	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APT_02161	COG1204	response to ionizing radiation
APT_02169	COG0583	DNA-binding transcription factor activity
APT_02170	COG1289	transmembrane transporter activity
APT_02176	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APT_02177	COG0805	protein transport
APT_02178	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APT_02179	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APT_02180	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APT_02182	COG0018	arginyl-trna synthetase
APT_02183	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APT_02184	COG0316	Belongs to the HesB IscA family
APT_02185	COG0708	Exodeoxyribonuclease III
APT_02190	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APT_02191	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
APT_02193	COG0535	radical SAM domain protein
APT_02195	COG0740	serine-type endopeptidase activity
APT_02197	COG0436	Aminotransferase
APT_02199	COG1494	fructose-1,6-bisphosphatase
APT_02201	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APT_02202	COG0564	pseudouridine synthase activity
APT_02203	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT_02204	COG1120	ATPase activity
APT_02205	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APT_02206	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APT_02207	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APT_02207	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APT_02213	COG1294	oxidase, subunit
APT_02214	COG1271	oxidase subunit
APT_02217	COG1113	amino acid transport
APT_02219	COG4993	Dehydrogenase
APT_02221	COG1942	4-Oxalocrotonate Tautomerase
APT_02223	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT_02226	COG0493	'glutamate synthase
APT_02230	COG1953	Uracil, thiamine, allantoin
APT_02232	COG0135	phosphoribosylanthranilate isomerase activity
APT_02233	COG0284	orotidine-5'-phosphate decarboxylase activity
APT_02235	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APT_02237	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APT_02238	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APT_02240	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APT_02244	COG3145	DNA-N1-methyladenine dioxygenase activity
APT_02246	COG3620	sequence-specific DNA binding
APT_02248	COG2011	ABC-type metal ion transport system permease component
APT_02249	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APT_02251	COG0277	FAD linked oxidase domain protein
APT_02252	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APT_02252	COG1648	precorrin-2 dehydrogenase activity
APT_02254	COG1846	Transcriptional regulator
APT_02255	COG0154	amidase activity
APT_02256	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT_02257	COG0235	Class ii aldolase
APT_02260	COG1028	Short-chain dehydrogenase reductase Sdr
APT_02262	COG4638	Rieske (2fe-2S)
APT_02266	COG1012	belongs to the aldehyde dehydrogenase family
APT_02271	COG1177	transmembrane transport
APT_02272	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT_02273	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APT_02274	COG3842	ATPase activity
APT_02275	COG1012	belongs to the aldehyde dehydrogenase family
APT_02278	COG3128	pkhd-type hydroxylase
APT_02281	COG4774	siderophore transport
APT_02283	COG0848	biopolymer transport protein
APT_02289	COG1301	dicarboxylic acid transport
APT_02296	COG2814	Major facilitator Superfamily
APT_02298	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
APT_02299	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
APT_02302	COG0778	Nitroreductase
APT_02303	COG1492	cobalamin metabolic process
APT_02306	COG1797	cobyrinic acid a,c-diamide synthase activity
APT_02312	COG1289	transmembrane transporter activity
APT_02313	COG1584	GPR1 FUN34 yaaH family protein
APT_02314	COG1024	Enoyl-CoA hydratase
APT_02315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT_02317	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APT_02318	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
APT_02320	COG0735	belongs to the Fur family
APT_02323	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
APT_02327	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APT_02327	COG0519	Catalyzes the synthesis of GMP from XMP
APT_02329	COG2814	Major facilitator Superfamily
APT_02330	COG1196	nuclear chromosome segregation
APT_02330	COG0741	lytic transglycosylase activity
APT_02330	COG0739	heme binding
APT_02334	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APT_02341	COG1742	UPF0060 membrane protein
APT_02344	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APT_02347	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APT_02348	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
APT_02350	COG0363	glucosamine-6-phosphate deaminase activity
APT_02351	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APT_02352	COG3265	gluconokinase activity
APT_02357	COG1063	alcohol dehydrogenase
APT_02359	COG3158	transport of potassium into the cell
APT_02360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APT_02363	COG0410	ABC transporter
APT_02364	COG0411	ABC transporter
APT_02366	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT_02368	COG2198	Histidine kinase
APT_02368	COG2205	protein histidine kinase activity
APT_02368	COG0784	Response regulator, receiver
APT_02368	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT_02369	COG0745	RESPONSE REGULATOR receiver
APT_02372	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APT_02373	COG0830	nickel cation binding
APT_02374	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
APT_02375	COG0804	urea catabolic process
APT_02376	COG0832	Belongs to the urease beta subunit family
APT_02377	COG0831	urea catabolic process
APT_02378	COG0829	nickel cation binding
APT_02379	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
APT_02380	COG3961	Belongs to the TPP enzyme family
APT_02385	COG1393	Belongs to the ArsC family
APT_02387	COG2818	Glycosylase
APT_02388	COG0640	Transcriptional regulator
APT_02389	COG0450	alkyl hydroperoxide reductase
APT_02398	COG0583	DNA-binding transcription factor activity
APT_02400	COG2271	Major facilitator Superfamily
APT_02401	COG3473	Maleate cis-trans isomerase
APT_02402	COG0596	Alpha beta hydrolase
APT_02403	COG1335	isochorismatase
APT_02404	COG2309	aminopeptidase activity
APT_02405	COG2010	Cytochrome c
APT_02405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APT_02406	COG2080	2 iron, 2 sulfur cluster binding
APT_02407	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT_02408	COG1846	Transcriptional regulator
APT_02412	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APT_02414	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APT_02418	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APT_02418	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APT_02419	COG0509	glycine decarboxylation via glycine cleavage system
APT_02420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APT_02422	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APT_02423	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
APT_02426	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APT_02427	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APT_02428	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APT_02431	COG1185	polyribonucleotide nucleotidyltransferase activity
APT_02432	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APT_02433	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APT_02434	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APT_02435	COG1127	ABC transporter
APT_02436	COG3008	intermembrane lipid transfer
APT_02436	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APT_02445	COG0646	methionine synthase
APT_02445	COG1410	methionine synthase
APT_02448	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APT_02450	COG3008	intermembrane lipid transfer
APT_02451	COG2995	paraquat-inducible protein a
APT_02452	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APT_02453	COG0463	Glycosyl transferase, family 2
APT_02454	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APT_02455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APT_02456	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APT_02457	COG0356	it plays a direct role in the translocation of protons across the membrane
APT_02460	COG0552	protein localization to endoplasmic reticulum
APT_02461	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APT_02462	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APT_02463	COG0346	lactoylglutathione lyase activity
APT_02465	COG0513	Belongs to the DEAD box helicase family
APT_02468	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APT_02469	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APT_02472	COG0704	Plays a role in the regulation of phosphate uptake
APT_02473	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APT_02475	COG0573	inorganic phosphate transmembrane transporter activity
APT_02476	COG0129	dihydroxy-acid dehydratase activity
APT_02485	COG0489	protein tyrosine kinase activity
APT_02488	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
APT_02490	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
APT_02490	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APT_02494	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT_02495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APT_02496	COG1522	sequence-specific DNA binding
APT_02497	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APT_02498	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APT_02501	COG0779	Required for maturation of 30S ribosomal subunits
APT_02503	COG0542	response to heat
APT_02506	COG0765	amino acid transport
APT_02507	COG1126	abc transporter atp-binding protein
APT_02509	COG4133	protoheme IX ABC transporter activity
APT_02513	COG1295	ribonuclease BN
APT_02515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APT_02516	COG0511	ligase activity, forming carbon-carbon bonds
APT_02517	COG0439	Biotin carboxylase
APT_02518	COG2814	Major facilitator Superfamily
APT_02519	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APT_02529	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APT_02531	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APT_02532	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APT_02533	COG0154	amidase activity
APT_02534	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APT_02535	COG5265	(ABC) transporter
APT_02536	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APT_02537	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APT_02538	COG1194	a g-specific adenine glycosylase
APT_02543	COG0495	leucyl-tRNA aminoacylation
APT_02553	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APT_02555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT_02556	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT_02557	COG0590	tRNA wobble adenosine to inosine editing
APT_02559	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APT_02560	COG1187	pseudouridine synthase activity
APT_02561	COG0742	ribosomal rna small subunit methyltransferase
APT_02562	COG0629	single-stranded DNA binding
APT_02564	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APT_02569	COG0438	transferase activity, transferring glycosyl groups
APT_02571	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APT_02572	COG0312	modulator of DNA gyrase
APT_02573	COG0406	alpha-ribazole phosphatase activity
APT_02577	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
APT_02578	COG1091	dTDP-4-dehydrorhamnose reductase activity
APT_02580	COG1674	ftsk spoiiie
APT_02581	COG0564	pseudouridine synthase activity
APT_02582	COG0438	transferase activity, transferring glycosyl groups
APT_02584	COG0482	sulfurtransferase activity
APT_02586	COG1104	cysteine desulfurase activity
APT_02589	COG2945	thiolester hydrolase activity
APT_02591	COG0215	cysteine-tRNA ligase activity
APT_02592	COG0285	dihydrofolate synthase activity
APT_02593	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APT_02596	COG2887	Belongs to the helicase family. UvrD subfamily
APT_02597	COG0802	atpase or kinase
APT_02598	COG0745	RESPONSE REGULATOR receiver
APT_02599	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APT_02601	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT_02602	COG0037	tRNA processing
APT_02604	COG2885	chlorophyll binding
APT_02605	COG0823	Involved in the tonB-independent uptake of proteins
APT_02607	COG0848	biopolymer transport protein
APT_02609	COG0824	Thioesterase
APT_02610	COG2255	four-way junction helicase activity
APT_02611	COG0632	four-way junction helicase activity
APT_02612	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APT_02613	COG0217	transcriptional regulatory protein
APT_02614	COG0653	protein targeting
APT_02615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT_02616	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APT_02618	COG0668	transmembrane transport
APT_02629	COG0776	regulation of translation
APT_02633	COG1216	Glycosyl transferase, family 2
APT_02635	COG0131	Imidazoleglycerol-phosphate dehydratase
APT_02636	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APT_02637	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APT_02638	COG0107	imidazoleglycerol-phosphate synthase activity
APT_02639	COG0140	phosphoribosyl-ATP diphosphatase activity
APT_02641	COG0778	Nitroreductase
APT_02647	COG1475	DNA binding
APT_02648	COG1192	Involved in chromosome partitioning
APT_02649	COG0357	Ribosomal RNA small subunit methyltransferase G
APT_02650	COG0445	tRNA wobble uridine modification
APT_02651	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APT_02652	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APT_02656	COG1611	Belongs to the LOG family
APT_02660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT_02661	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APT_02662	COG0424	maF-like protein
APT_10003	COG2894	cell division
APT_10005	COG1475	DNA binding
APT_10019	COG0629	single-stranded DNA binding
APT_10041	COG1280	lysine exporter protein (LysE YggA)
APT_10044	COG4957	zinc ion binding
APT_10064	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APT_10067	COG2801	Transposase and inactivated derivatives
APT_10069	COG1999	signal sequence binding
APT_10075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APT_10076	COG0735	belongs to the Fur family
APT_10078	COG0302	gtp cyclohydrolase
APT_10079	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APT_10080	COG0523	cobalamin synthesis protein
APT_10081	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
APT_10082	COG0640	Transcriptional regulator
APT_10094	COG1959	2 iron, 2 sulfur cluster binding
APT_10095	COG1196	nuclear chromosome segregation
APT_10096	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APT_10097	COG2818	Glycosylase
APT_10098	COG3145	DNA-N1-methyladenine dioxygenase activity
APT_10101	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APT_10101	COG2169	Transcriptional regulator
APT_10105	COG0667	Aldo Keto reductase
APT_10106	COG0656	L-ascorbic acid biosynthetic process
APT_10108	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
APT_10110	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
APT_10114	COG1999	signal sequence binding
APT_10116	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APT_10124	COG1959	2 iron, 2 sulfur cluster binding
APT_10127	COG4221	oxidoreductase activity
APT_10130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APT_10137	COG0583	DNA-binding transcription factor activity
APT_10149	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APT_10150	COG4957	zinc ion binding
APT_10156	COG1522	sequence-specific DNA binding
APT_10157	COG1280	lysine exporter protein (LysE YggA)
APT_10158	COG0583	DNA-binding transcription factor activity
APT_10159	COG0679	Auxin Efflux Carrier
APT_10160	COG0583	DNA-binding transcription factor activity
APT_10161	COG1028	Short-chain dehydrogenase reductase Sdr
APT_10163	COG2072	flavoprotein involved in K transport
APT_10166	COG2144	transferase activity, transferring acyl groups
APT_10171	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT_10173	COG0583	DNA-binding transcription factor activity
APT_10176	COG2211	Major facilitator Superfamily
APT_10177	COG1902	pentaerythritol trinitrate reductase activity
APT_10178	COG4221	oxidoreductase activity
APT_10179	COG1917	Cupin 2, conserved barrel domain protein
APT_10179	COG4977	sequence-specific DNA binding
APT_10180	COG1408	metallophosphoesterase
APT_10187	COG1028	Short-chain dehydrogenase reductase Sdr
APT_10189	COG1028	Short-chain dehydrogenase reductase Sdr
APT_10194	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APT_10195	COG0587	DNA-directed DNA polymerase activity
APT_10196	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT_10197	COG0071	Belongs to the small heat shock protein (HSP20) family
APT_10201	COG4974	Belongs to the 'phage' integrase family
APT_20004	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs