locus-tag	class	description
A4S02_00045	ENOG4105D3R	alkyl hydroperoxide reductase
A4S02_00055	ENOG4108R3E	Dna-3-methyladenine glycosylase i
A4S02_00065	ENOG4105KUZ	arsenate reductase
A4S02_00070	ENOG4108UQY	Iron-storage protein
A4S02_00100	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
A4S02_00105	ENOG4108YZ9	Urea amidohydrolase subunit gamma
A4S02_00110	ENOG4105KI2	Urea amidohydrolase subunit beta
A4S02_00115	ENOG4105CQM	Urea amidohydrolase subunit alpha
A4S02_00120	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
A4S02_00125	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
A4S02_00130	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
A4S02_00145	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
A4S02_00150	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
A4S02_00175	ENOG4105C32	Amino acid ABC transporter (Permease)
A4S02_00185	ENOG4105C0Z	ABC transporter
A4S02_00190	ENOG4108IV0	ABC, transporter
A4S02_00220	ENOG4105CSA	Coproporphyrinogen iii oxidase
A4S02_00225	ENOG4105DFH	Transport of potassium into the cell (By similarity)
A4S02_00230	ENOG4105DFA	alanine racemase domain protein
A4S02_00235	ENOG4105CPQ	Dehydrogenase
A4S02_00260	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
A4S02_00265	ENOG4105E66	phosphoriboisomerase A
A4S02_00270	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
A4S02_00275	ENOG4108AZI	Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity)
A4S02_00280	ENOG4108J5G	6-phosphogluconate dehydrogenase
A4S02_00285	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
A4S02_00300	ENOG4105CIH	Imidazole acetol-phosphate transaminase
A4S02_00315	ENOG4105KK4	UPF0060 membrane protein
A4S02_00345	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
A4S02_00355	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
A4S02_00370	ENOG4105DAA	L-lactate
A4S02_00375	ENOG4105E4C	Lytic transglycosylase catalytic
A4S02_00380	ENOG4107QNK	)-transporter
A4S02_00395	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
A4S02_00400	ENOG4105C6T	cysteine synthase
A4S02_00415	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
A4S02_00430	ENOG4105MYN	Zinc uptake regulation protein
A4S02_00440	ENOG4105D5T	phosphonate abc transporter
A4S02_00445	ENOG4105FAV	ABC, transporter
A4S02_00450	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
A4S02_00455	ENOG4105CGU	Enoyl-CoA hydratase
A4S02_00475	ENOG4105DSW	Fusaric acid resistance protein
A4S02_00500	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
A4S02_00510	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
A4S02_00515	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
A4S02_00520	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
A4S02_00530	ENOG4105EFT	decarboxylase
A4S02_00535	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
A4S02_00540	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
A4S02_00550	ENOG4105F27	Major Facilitator
A4S02_00605	ENOG4105CK2	sodium dicarboxylate symporter
A4S02_00630	ENOG4105EQR	Transposase IS116 IS110 IS902
A4S02_00650	ENOG4105EXC	Acyl-transferase
A4S02_00685	ENOG4105C72	UPF0176 protein
A4S02_00840	ENOG4105K78	MarR family Transcriptional regulator
A4S02_00845	ENOG4105KPV	Transcriptional regulator
A4S02_00850	ENOG4105EMU	Dehydrogenase
A4S02_00905	ENOG4105C9K	Endothelin-converting enzyme 1
A4S02_00930	ENOG4105EQR	Transposase IS116 IS110 IS902
A4S02_00955	ENOG4105CPP	Dehydrogenase, E1 component
A4S02_00960	ENOG4108EMS	branched-chain alpha-keto acid dehydrogenase subunit E2
A4S02_00965	ENOG4105VN1	Heat shock protein
A4S02_00975	ENOG4105CEP	NADH dehydrogenase
A4S02_00985	ENOG4105CKI	cobalamin synthesis protein
A4S02_01010	ENOG4105PGM	cation diffusion facilitator family transporter
A4S02_01015	ENOG4105DZ0	fad dependent oxidoreductase
A4S02_01020	ENOG4105EV9	Alpha Beta Hydrolase
A4S02_01035	ENOG4105EPD	Oligopeptide transporter, Opt family
A4S02_01065	ENOG4105D06	uba thif-type nad fad binding protein
A4S02_01075	ENOG4105CA9	Pyruvate kinase
A4S02_01095	ENOG4105CI3	gtp-binding protein typa
A4S02_01105	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
A4S02_01115	ENOG4105CAY	ferredoxin--nadp reductase
A4S02_01140	ENOG4108YZA	Nitrogen regulatory protein pii
A4S02_01145	ENOG4105C5F	glutamine synthetase
A4S02_01195	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
A4S02_01200	ENOG4105DWV	Homoserine O-trans-acetylase
A4S02_01205	ENOG4105DWV	Homoserine O-trans-acetylase
A4S02_01210	ENOG4105C1J	atp-dependent rna helicase
A4S02_01220	ENOG4107B2H	carbonic anhydrase
A4S02_01230	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4S02_01235	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
A4S02_01240	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
A4S02_01245	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
A4S02_01250	ENOG4105C3F	Signal peptidase i
A4S02_01255	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
A4S02_01260	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
A4S02_01265	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
A4S02_01270	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
A4S02_01275	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
A4S02_01285	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
A4S02_01290	ENOG4105DZP	Membrane-associated zinc metalloprotease
A4S02_01295	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4S02_01305	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A4S02_01310	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
A4S02_01315	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A4S02_01320	ENOG4105GYT	Protein of unknown function (DUF1009)
A4S02_01325	ENOG4108UYE	Lactoylglutathione lyase
A4S02_01335	ENOG4105VG0	50S ribosomal protein l34
A4S02_01340	ENOG41087PG	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
A4S02_01345	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
A4S02_01350	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
A4S02_01355	ENOG4105CAS	nag kinase
A4S02_01360	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
A4S02_01365	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
A4S02_01375	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
A4S02_01380	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
A4S02_01390	ENOG4108ZNX	Heat shock protein
A4S02_01400	ENOG4107TNS	sigma 54 modulation protein ribosomal protein S30ea
A4S02_01410	ENOG4105QVC	MOSC domain-containing protein
A4S02_01415	ENOG4108IUZ	ABC transporter
A4S02_01430	ENOG4105C2X	Arabinose 5-phosphate isomerase
A4S02_01440	ENOG4105C2N	RNA methyltransferase TrmH family group 3
A4S02_01450	ENOG4105EMU	Dehydrogenase
A4S02_01455	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
A4S02_01460	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
A4S02_01465	ENOG4107SZR	mannose-6-phosphate isomerase
A4S02_01500	ENOG4105EGS	Mechanosensitive ion channel
A4S02_01505	ENOG4105DHJ	ABC, transporter
A4S02_01510	ENOG4105CY3	ABC transporter, permease
A4S02_01555	ENOG4105C85	amino acid
A4S02_01565	ENOG4105C26	Dehydrogenase
A4S02_01585	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
A4S02_01640	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
A4S02_01645	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
A4S02_01650	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
A4S02_01660	ENOG4105CV8	reductase
A4S02_01670	ENOG4105CQ7	ATP-dependent helicase
A4S02_01680	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
A4S02_01690	ENOG4105DBV	ornithine carbamoyltransferase
A4S02_01695	ENOG4105C8Y	Acetylornithine aminotransferase
A4S02_01715	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
A4S02_01720	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
A4S02_01725	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
A4S02_01730	ENOG4105DTN	riboflavin biosynthesis protein ribF
A4S02_01735	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
A4S02_01740	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
A4S02_01750	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
A4S02_01755	ENOG4105C8S	subunit m
A4S02_01760	ENOG4107AQZ	Membrane
A4S02_01765	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A4S02_01780	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
A4S02_01800	ENOG4105CN1	protease
A4S02_01805	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
A4S02_01815	ENOG4105C79	DNA protecting protein DprA
A4S02_01820	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
A4S02_01825	ENOG4105CD3	dihydroorotase
A4S02_01830	ENOG4105CXT	aspartate transcarbamylase
A4S02_01835	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
A4S02_01845	ENOG4105EQR	Transposase IS116 IS110 IS902
A4S02_01865	ENOG4105D6Z	AFG1 family ATPase
A4S02_01875	ENOG4105C7S	Dehydrogenase
A4S02_01880	ENOG4107QN2	dihydrolipoyl dehydrogenase
A4S02_01895	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
A4S02_01910	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
A4S02_01940	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A4S02_01945	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
A4S02_01950	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
A4S02_01955	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
A4S02_01960	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
A4S02_01975	ENOG4105D49	3-dehydroquinate synthase
A4S02_01985	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
A4S02_01990	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
A4S02_01995	ENOG4105CEV	competence damage-inducible protein
A4S02_02000	ENOG4105DK7	lysyl-tRNA synthetase
A4S02_02015	ENOG4105D6S	protein involved in catabolism of external DNA
A4S02_02020	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
A4S02_02025	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
A4S02_02035	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
A4S02_02050	ENOG4105CEC	DNA methylase N-4 N-6
A4S02_02055	ENOG4105CA0	peroxidase
A4S02_02070	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
A4S02_02075	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
A4S02_02080	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
A4S02_02085	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
A4S02_02105	ENOG4108RCM	Nitroreductase
A4S02_02115	ENOG4108WUH	Transcriptional regulator, TetR family
A4S02_02120	ENOG4108I6A	alcohol dehydrogenase
A4S02_02125	ENOG4105C26	Dehydrogenase
A4S02_02185	ENOG4105E5H	Transposase
A4S02_02195	ENOG41061A5	transposase
A4S02_02230	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
A4S02_02235	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
A4S02_02240	ENOG4105YVS	arsR family transcriptional regulator
A4S02_02250	ENOG4108CHM	Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases
A4S02_02255	ENOG4105CMR	udp-glucose 4-epimerase
A4S02_02270	ENOG4105CH7	arginosuccinase
A4S02_02285	ENOG4105E2X	shikimate dehydrogenase
A4S02_02290	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
A4S02_02315	ENOG4105DJV	ribulose-phosphate 3-epimerase
A4S02_02320	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
A4S02_02325	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
A4S02_02330	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
A4S02_02340	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
A4S02_02360	ENOG4105FDK	ABC transporter
A4S02_02395	ENOG4105DSW	Fusaric acid resistance protein
A4S02_02400	ENOG4105DSW	Fusaric acid resistance protein
A4S02_02420	ENOG4105KWW	Biogenesis protein
A4S02_02425	ENOG4107QX9	Thiol disulfide interChange protein
A4S02_02430	ENOG4105DA4	cytochrome c-type biogenesis protein
A4S02_02435	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
A4S02_02440	ENOG41060IM	Heme exporter protein
A4S02_02475	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
A4S02_02505	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4S02_02545	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
A4S02_02550	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
A4S02_02555	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
A4S02_02560	ENOG4108VZM	50s ribosomal protein L10
A4S02_02565	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
A4S02_02570	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
A4S02_02575	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
A4S02_02580	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
A4S02_02585	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
A4S02_02590	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
A4S02_02595	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
A4S02_02600	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
A4S02_02605	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
A4S02_02610	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
A4S02_02615	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4S02_02620	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
A4S02_02625	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
A4S02_02630	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
A4S02_02635	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
A4S02_02640	ENOG41083MP	50s ribosomal protein l29
A4S02_02645	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
A4S02_02650	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
A4S02_02655	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
A4S02_02660	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4S02_02665	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
A4S02_02670	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
A4S02_02675	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
A4S02_02680	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
A4S02_02685	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
A4S02_02690	ENOG41084HQ	50S ribosomal protein L30
A4S02_02695	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
A4S02_02705	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
A4S02_02710	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4S02_02715	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
A4S02_02720	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
A4S02_02725	ENOG4108ZT0	50S ribosomal protein l17
A4S02_02735	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
A4S02_02740	ENOG4105D7T	ABC transporter
A4S02_02760	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
A4S02_02765	ENOG4105BZS	acriflavin resistance protein
A4S02_02770	ENOG4105BZS	acriflavin resistance protein
A4S02_02775	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
A4S02_02780	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
A4S02_02790	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
A4S02_02795	ENOG4105CEC	DNA methylase N-4 N-6
A4S02_02820	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
A4S02_02830	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
A4S02_02835	ENOG4105BZ1	(ABC) transporter
A4S02_02840	ENOG4105CW7	secretion protein, HlyD family
A4S02_02845	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
A4S02_02850	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
A4S02_02860	ENOG4105CN1	protease
A4S02_02875	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
A4S02_02880	ENOG4105C7B	Threonine dehydratase
A4S02_02885	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
A4S02_02890	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
A4S02_02895	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
A4S02_02905	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
A4S02_02910	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
A4S02_02920	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
A4S02_02925	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
A4S02_02930	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
A4S02_02935	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
A4S02_02940	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
A4S02_02945	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
A4S02_02950	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
A4S02_02970	ENOG4105BZ1	(ABC) transporter
A4S02_02975	ENOG4108WYP	Transcriptional regulator
A4S02_02980	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
A4S02_02985	ENOG4107QMS	site-determining protein
A4S02_02990	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
A4S02_03000	ENOG4105CBX	hi0933 family
A4S02_03005	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
A4S02_03015	ENOG4105RQ9	TPR repeat-containing protein
A4S02_03020	ENOG4108VJ1	Transcriptional regulator (CarD family
A4S02_03025	ENOG4105FFC	UPF0187 protein
A4S02_03030	ENOG4105C4W	S-formylglutathione hydrolase
A4S02_03045	ENOG4105CAK	Cell division ATP-binding protein ftsE
A4S02_03070	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
A4S02_03075	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
A4S02_03080	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
A4S02_03095	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
A4S02_03100	ENOG4105DEI	Mannitol dehydrogenase
A4S02_03105	ENOG41082BR	50S ribosomal protein L35
A4S02_03110	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
A4S02_03115	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
A4S02_03120	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
A4S02_03155	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
A4S02_03170	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
A4S02_03175	ENOG4105DC7	peptidase M24
A4S02_03180	ENOG4107RQ5	Methylates ribosomal protein L11 (By similarity)
A4S02_03190	ENOG4105W5Q	DNA repair protein (RadC
A4S02_03195	ENOG4105W5Q	DNA repair protein (RadC
A4S02_03200	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
A4S02_03225	ENOG4108ZNX	Heat shock protein
A4S02_03230	ENOG41082FS	50S ribosomal protein L31
A4S02_03235	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
A4S02_03245	ENOG4107QT7	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
A4S02_03250	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
A4S02_03260	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
A4S02_03265	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
A4S02_03275	ENOG4105EAH	synthase
A4S02_03280	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
A4S02_03285	ENOG4107SW0	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
A4S02_03300	ENOG4105M4E	phosphohistidine phosphatase, SixA
A4S02_03305	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
A4S02_03330	ENOG4108R9S	DSBA oxidoreductase
A4S02_03335	ENOG4105C37	(CBS) domain
A4S02_03340	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
A4S02_03350	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
A4S02_03360	ENOG4105CFU	surface antigen
A4S02_03375	ENOG4108IGT	Dipeptidase
A4S02_03380	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
A4S02_03395	ENOG4105M00	molybdopterin converting factor, subunit 1
A4S02_03400	ENOG4108ZAF	Molybdopterin
A4S02_03405	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
A4S02_03410	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
A4S02_03420	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
A4S02_03425	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
A4S02_03430	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
A4S02_03435	ENOG4105W0E	50S ribosomal protein L33
A4S02_03445	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
A4S02_03465	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
A4S02_03475	ENOG4105CB5	ATP-dependent DNA helicase recG
A4S02_03480	ENOG4107NKQ	Flavinator of succinate dehydrogenase
A4S02_03495	ENOG4105DHU	Bile acid
A4S02_03500	ENOG4105DY8	decarboxylase
A4S02_03515	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
A4S02_03520	ENOG4105M85	Bola protein
A4S02_03530	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
A4S02_03550	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
A4S02_03555	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
A4S02_03560	ENOG4105MJ2	Competence protein
A4S02_03565	ENOG4105VW4	glutaredoxin 3
A4S02_03580	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
A4S02_03585	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
A4S02_03590	ENOG4105CFH	Aspartokinase
A4S02_03595	ENOG4105EA8	2-Nitropropane dioxygenase
A4S02_03605	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
A4S02_03610	ENOG4105CUT	histidyl-tRNA synthetase
A4S02_03615	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
A4S02_03625	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
A4S02_03645	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
A4S02_03650	ENOG4105CUB	amino acid
A4S02_03665	ENOG4105CVE	Lytic murein transglycosylase
A4S02_03670	ENOG4105K6T	rare lipoprotein A
A4S02_03675	ENOG4105DZ1	carboxypeptidase
A4S02_03680	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
A4S02_03695	ENOG4105F8V	Hydrolase, tatD family
A4S02_03710	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
A4S02_03715	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
A4S02_03720	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
A4S02_03725	ENOG4108Z9K	Osmotically inducible protein
A4S02_03730	ENOG4105DWT	malate dehydrogenase (quinone)
A4S02_03740	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
A4S02_03745	ENOG4107RJX	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
A4S02_03750	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
A4S02_03760	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
A4S02_03765	ENOG4105C11	sulfate adenylyltransferase), subunit 2
A4S02_03780	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
A4S02_03790	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
A4S02_03795	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
A4S02_03815	ENOG4105HHA	aminodeoxychorismate lyase
A4S02_03820	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
A4S02_03825	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
A4S02_03835	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
A4S02_03865	ENOG4105VEQ	Cold shock protein
A4S02_03870	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
A4S02_03875	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
A4S02_03880	ENOG4105CQC	Prephenate dehydratase
A4S02_03885	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
A4S02_03890	ENOG4105XUA	cytochrome c
A4S02_03900	ENOG4108JQ1	Dehydrogenase
A4S02_03905	ENOG4105C0P	Mg chelatase subunit ChlI
A4S02_03935	ENOG4105C28	cystathionine
A4S02_03940	ENOG4105KHC	sulfurtransferase
A4S02_03945	ENOG4105IPI	Membrane
A4S02_03955	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
A4S02_03960	ENOG41082FP	UPF0102 protein
A4S02_03980	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
A4S02_03985	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
A4S02_03995	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
A4S02_04000	ENOG4107QPR	SAICAR synthetase
A4S02_04005	ENOG4105C83	adenylosuccinate lyase
A4S02_04010	ENOG4108ZCF	integral membrane protein
A4S02_04015	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
A4S02_04025	ENOG4107TH8	cina domain protein
A4S02_04040	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
A4S02_04045	ENOG4107QN2	dihydrolipoyl dehydrogenase
A4S02_04050	ENOG4105C7S	Dehydrogenase
A4S02_04055	ENOG4105CPP	Dehydrogenase, E1 component
A4S02_04060	ENOG4108JYK	Dehydrogenase
A4S02_04065	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
A4S02_04070	ENOG4105DK0	Indole-3-glycerol phosphate synthase
A4S02_04075	ENOG4107QYG	anthranilate phosphoribosyltransferase
A4S02_04080	ENOG4105DDQ	anthranilate synthase
A4S02_04085	ENOG4105CRQ	synthase (Component I)
A4S02_04095	ENOG4105CP7	Triose-phosphate isomerase
A4S02_04105	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
A4S02_04110	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
A4S02_04115	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A4S02_04120	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
A4S02_04125	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
A4S02_04130	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
A4S02_04135	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
A4S02_04140	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
A4S02_04145	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
A4S02_04150	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
A4S02_04155	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
A4S02_04160	ENOG4105F38	ABC transporter, permease
A4S02_04165	ENOG4108IY8	ABC, transporter
A4S02_04170	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
A4S02_04175	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
A4S02_04200	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
A4S02_04220	ENOG4105CHR	reductase
A4S02_04230	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
A4S02_04235	ENOG4107XZX	Involved in the transcription termination process (By similarity)
A4S02_04240	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
A4S02_04250	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
A4S02_04255	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
A4S02_04260	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
A4S02_04265	ENOG4105E98	transcriptional regulator DeoR family
A4S02_04270	ENOG4105C9U	ATP-dependent DNA helicase RecQ
A4S02_04280	ENOG4108JJ8	(ABC) transporter
A4S02_04285	ENOG4108JJ9	ABC, transporter
A4S02_04310	ENOG41074H6	response regulator
A4S02_04315	ENOG4105C5H	ABC transporter
A4S02_04330	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
A4S02_04335	ENOG4105C44	Serine transporter
A4S02_04365	ENOG4105JAB	phenazine biosynthesis protein, phzf family
A4S02_04385	ENOG4105D7T	ABC transporter
A4S02_04405	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
A4S02_04430	ENOG4105C5R	Aminotransferase
A4S02_04455	ENOG4105C7W	Xanthine dehydrogenase
A4S02_04465	ENOG4105C2W	permease
A4S02_04470	ENOG4105VT2	5-hydroxyisourate hydrolase
A4S02_04485	ENOG4105E1J	oxidoreductase
A4S02_04495	ENOG4107QUY	Guanine deaminase
A4S02_04500	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
A4S02_04545	ENOG4105D0S	secretion protein (HlyD
A4S02_04550	ENOG4105CJ1	ABC, transporter
A4S02_04555	ENOG4105CMI	transporter
A4S02_04570	ENOG4105HMI	Membrane
A4S02_04580	ENOG4105EWU	Squalene--hopene cyclase
A4S02_04600	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
A4S02_04610	ENOG4108YZN	class I peptide chain release factor
A4S02_04645	ENOG4105E2V	Glycosyltransferase 36
A4S02_04650	ENOG4105CI2	imidazolone-5-propionate hydrolase
A4S02_04670	ENOG4105DWF	phosphomethylpyrimidine kinase
A4S02_04685	ENOG4105CNM	Receptor
A4S02_04705	ENOG4105CFG	Acts as a chaperone (By similarity)
A4S02_04715	ENOG4105BZS	acriflavin resistance protein
A4S02_04750	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
A4S02_04760	ENOG4105MRR	Transcriptional regulator (By similarity)
A4S02_04765	ENOG4105EIG	urea carboxylase-associated protein 1
A4S02_04770	ENOG4105EIG	urea carboxylase-associated protein 1
A4S02_04775	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
A4S02_04800	ENOG4105MP0	transposase
A4S02_04830	ENOG4107QSN	dihydrolipoamide acetyltransferase
A4S02_04915	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
A4S02_04965	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
A4S02_04970	ENOG4105EHG	Permease protein
A4S02_04975	ENOG4107R4I	Periplasmic binding protein
A4S02_04985	ENOG4107RGH	Aldehyde dehydrogenase
A4S02_04995	ENOG4105KST	dependent repressor
A4S02_05000	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
A4S02_05040	ENOG4105CT4	transporter
A4S02_05050	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
A4S02_05055	ENOG4105EQR	Transposase IS116 IS110 IS902
A4S02_05115	ENOG4105EEQ	Na H antiporter
A4S02_05130	ENOG4105PPN	plasmid maintenance protein, CcdB
A4S02_05135	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
A4S02_05140	ENOG4105VGJ	Virulence-associated protein
A4S02_05165	ENOG4105C59	p-type ATPase
A4S02_05170	ENOG4105CMQ	Chloride channel
A4S02_05180	ENOG4105C7H	Helicase, RecD TraA family
A4S02_05255	ENOG4107QJT	sodium dicarboxylate symporter
A4S02_05260	ENOG4105FQ6	thiopurine methyltransferase
A4S02_05265	ENOG4105E9S	glutaredoxin 2
A4S02_05270	ENOG4105IE8	Alpha-ketoglutarate permease
A4S02_05275	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
A4S02_05325	ENOG4105C9Q	fumarate hydratase class II
A4S02_05355	ENOG4105DZG	Dehydrogenase
A4S02_05410	ENOG4105EQR	Transposase IS116 IS110 IS902
A4S02_05460	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
A4S02_05485	ENOG4108UI1	Probably functions as a manganese efflux pump (By similarity)
A4S02_05495	ENOG4105E5H	Transposase
A4S02_05505	ENOG41061A5	transposase
A4S02_05510	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
A4S02_05520	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
A4S02_05525	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
A4S02_05530	ENOG4105F46	Necessary for formate dehydrogenase activity (By similarity)
A4S02_05535	ENOG4108MG3	formate dehydrogenase
A4S02_05540	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
A4S02_05545	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
A4S02_05555	ENOG4105C9X	ppx gppa phosphatase
A4S02_05560	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
A4S02_05570	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
A4S02_05575	ENOG41083BM	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
A4S02_05580	ENOG4105CTB	Polyprenyl synthetase
A4S02_05585	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
A4S02_05590	ENOG4105DX0	Hemolysin A
A4S02_05600	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
A4S02_05605	ENOG4105CDH	Citrulline--aspartate ligase
A4S02_05610	ENOG4108V1T	peptidylprolyl cis-trans isomerase
A4S02_05620	ENOG4105C31	Tryptophanyl-tRNA synthetase
A4S02_05635	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
A4S02_05650	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
A4S02_05665	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
A4S02_05750	ENOG4105NTW	Transcriptional regulator
A4S02_05815	ENOG4105D64	Mechanosensitive ion channel
A4S02_05830	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
A4S02_05835	ENOG4105C4M	(Ubiquinol oxidase) subunit I
A4S02_05845	ENOG4108JJ9	ABC, transporter
A4S02_05895	ENOG4105C5H	ABC transporter
A4S02_05910	ENOG4105EQR	Transposase IS116 IS110 IS902
A4S02_06030	ENOG4105F6U	Short-chain dehydrogenase reductase Sdr
A4S02_06040	ENOG4105CHR	reductase
A4S02_06065	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
A4S02_06090	ENOG4105EQR	Transposase IS116 IS110 IS902
A4S02_06125	ENOG4108JJA	ABC, transporter
A4S02_06140	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
A4S02_06145	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
A4S02_06150	ENOG4107TUM	Amidinotransferase
A4S02_06155	ENOG4105EVZ	LysR family transcriptional regulator
A4S02_06160	ENOG4105EAD	ABC transporter
A4S02_06165	ENOG4105CDA	abc transporter atp-binding protein
A4S02_06185	ENOG4105MP9	class II Aldolase
A4S02_06240	ENOG4107RCI	amp-dependent synthetase and ligase
A4S02_06250	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
A4S02_06265	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
A4S02_06290	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
A4S02_06295	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
A4S02_06300	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
A4S02_06320	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
A4S02_06330	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
A4S02_06340	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
A4S02_06345	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
A4S02_06350	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A4S02_06355	ENOG4105D65	subunit l
A4S02_06360	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A4S02_06365	ENOG4105DF2	NADH dehydrogenase subunit j
A4S02_06370	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A4S02_06375	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
A4S02_06405	ENOG4107QIZ	NADH dehydrogenase
A4S02_06415	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A4S02_06420	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A4S02_06425	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A4S02_06440	ENOG4105K70	DNA-binding protein
A4S02_06445	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
A4S02_06450	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
A4S02_06455	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
A4S02_06460	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
A4S02_06470	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
A4S02_06480	ENOG4105C1J	atp-dependent rna helicase
A4S02_06490	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
A4S02_06495	ENOG4105VG1	fes assembly suf system protein
A4S02_06505	ENOG4105C9B	Cysteine desulfurase
A4S02_06510	ENOG4105JRK	feS assembly protein SufD
A4S02_06530	ENOG4106BRA	Membrane
A4S02_06545	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
A4S02_06550	ENOG4105KDC	50s ribosomal protein l28
A4S02_06560	ENOG4108JJ7	ABC transporter
A4S02_06570	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
A4S02_06575	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
A4S02_06585	ENOG4105CTD	carboxy-peptidase
A4S02_06595	ENOG4105D98	threonine synthase
A4S02_06600	ENOG4105C1V	Peptidase, M16
A4S02_06605	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
A4S02_06620	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
A4S02_06625	ENOG4105BZ9	Cytochrome C oxidase, subunit I
A4S02_06630	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
A4S02_06655	ENOG4105F7P	transcriptional regulator AsnC family
A4S02_06660	ENOG4105C3M	thioredoxin reductase
A4S02_06665	ENOG4108PZW	LysR family Transcriptional regulator
A4S02_06675	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
A4S02_06695	ENOG4105CJR	Integral membrane protein (MviN
A4S02_06710	ENOG4105WJX	transcriptional regulator MERR family
A4S02_06715	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
A4S02_06720	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
A4S02_06725	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
A4S02_06730	ENOG41082R8	50S ribosomal protein l32
A4S02_06745	ENOG4105E0F	Histidine kinase
A4S02_06750	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
A4S02_06755	ENOG41090HR	transcriptional regulator
A4S02_06765	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
A4S02_06770	ENOG4105K5G	30S ribosomal protein S21
A4S02_06775	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
A4S02_06780	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
A4S02_06785	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
A4S02_06790	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
A4S02_06795	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
A4S02_06800	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
A4S02_06805	ENOG4105K5M	30s ribosomal protein S16
A4S02_06830	ENOG4105EI2	Pseudouridine synthase
A4S02_06835	ENOG4105D1H	recombination factor protein RarA
A4S02_06855	ENOG4105D1K	glutamate--cysteine ligase
A4S02_06860	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
A4S02_06865	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
A4S02_06870	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
A4S02_06890	ENOG4107TYR	Glycosyl Transferase
A4S02_06900	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
A4S02_06905	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
A4S02_06910	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A4S02_06915	ENOG4105CHH	sulfate transporter
A4S02_06920	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
A4S02_06935	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
A4S02_06950	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
A4S02_06955	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
A4S02_06960	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
A4S02_06985	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
A4S02_07035	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
A4S02_07045	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
A4S02_07060	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
A4S02_07070	ENOG4108YZA	Nitrogen regulatory protein pii
A4S02_07075	ENOG4105D7W	serine acetyltransferase
A4S02_07080	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
A4S02_07135	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
A4S02_07140	ENOG4105ECY	inositol monophosphatase
A4S02_07145	ENOG4105DVT	helicase
A4S02_07160	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
A4S02_07165	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
A4S02_07205	ENOG41061A5	transposase
A4S02_07240	ENOG4105BZU	Histidine kinase
A4S02_07260	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
A4S02_07265	ENOG4105C25	Primosomal protein n'
A4S02_07280	ENOG4105D7V	transposase
A4S02_07295	ENOG4105M6F	mutator MutT protein
A4S02_07310	ENOG4105NWN	ApaG protein
A4S02_07315	ENOG4105EUJ	GTP cyclohydrolase i
A4S02_07325	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
A4S02_07355	ENOG4105Y49	secretion protein, HlyD family
A4S02_07385	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
A4S02_07390	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
A4S02_07395	ENOG4108R6K	riboflavin synthase, subunit alpha
A4S02_07400	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
A4S02_07405	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
A4S02_07410	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
A4S02_07415	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
A4S02_07435	ENOG4105C7N	Xanthine uracil vitamin C permease
A4S02_07535	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
A4S02_07540	ENOG4105K46	50S ribosomal protein l27
A4S02_07545	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4S02_07550	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
A4S02_07560	ENOG4105Y2X	UPF0335 protein
A4S02_07565	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
A4S02_07585	ENOG4107YUR	Cell division protein mraZ
A4S02_07590	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
A4S02_07605	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
A4S02_07615	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
A4S02_07620	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
A4S02_07630	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
A4S02_07635	ENOG4105DFU	Cell wall formation (By similarity)
A4S02_07640	ENOG4105D4A	Cell wall formation (By similarity)
A4S02_07645	ENOG4105CPF	Cell wall formation (By similarity)
A4S02_07650	ENOG4108UFP	Essential cell division protein (By similarity)
A4S02_07655	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
A4S02_07665	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A4S02_07670	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4S02_07675	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
A4S02_07680	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
A4S02_07685	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
A4S02_07690	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
A4S02_07715	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
A4S02_07730	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
A4S02_07735	ENOG4108RWI	nicotinamidase
A4S02_07755	ENOG4105E3B	Multicopper oxidase
A4S02_07765	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
A4S02_07770	ENOG4108ZP8	Acetolactate synthase small subunit
A4S02_07775	ENOG4105C7K	acetolactate synthase
A4S02_07780	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
A4S02_07785	ENOG4105EAC	phosphoserine phosphatase
A4S02_07800	ENOG4105C1J	atp-dependent rna helicase
A4S02_07820	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
A4S02_07825	ENOG4105CUB	amino acid
A4S02_07830	ENOG4105D52	delta-aminolevulinic acid dehydratase
A4S02_07855	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A4S02_07860	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
A4S02_07865	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
A4S02_07870	ENOG4105CE9	30S ribosomal protein S2
A4S02_07900	ENOG4105C0B	DNA polymerase III (alpha subunit)
A4S02_07905	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
A4S02_07910	ENOG4105M4H	endoribonuclease L-psp
A4S02_07925	ENOG4105CHM	Aminotransferase
A4S02_07930	ENOG4105CHM	Aminotransferase
A4S02_07935	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
A4S02_07970	ENOG4105EPH	radical SAM domain protein
A4S02_07975	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
A4S02_07980	ENOG4105C5H	ABC transporter
A4S02_07985	ENOG4105C02	permease
A4S02_07990	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
A4S02_07995	ENOG41062D9	Histidine kinase
A4S02_08005	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
A4S02_08010	ENOG4105C22	threonyL-tRNA synthetase
A4S02_08030	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
A4S02_08045	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
A4S02_08050	ENOG4105CUV	Homoserine Kinase
A4S02_08055	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
A4S02_08095	ENOG4105DFI	Membrane
A4S02_08100	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
A4S02_08105	ENOG4105C03	ribonuclease
A4S02_08110	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
A4S02_08115	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
A4S02_08120	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
A4S02_08125	ENOG4108Z03	MAF-like protein
A4S02_08135	ENOG4105VYE	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
A4S02_08165	ENOG4105CXG	d-lactate dehydrogenase
A4S02_08215	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
A4S02_08230	ENOG4108WUH	Transcriptional regulator, TetR family
A4S02_08235	ENOG4105CEP	NADH dehydrogenase
A4S02_08245	ENOG4105C26	Dehydrogenase
A4S02_08250	ENOG4105F27	Major Facilitator
A4S02_08260	ENOG4108YYH	Nadph-dependent fmn reductase
A4S02_08265	ENOG4105EUB	pirin domain protein
A4S02_08360	ENOG4105DZ2	Transcriptional regulator
A4S02_08395	ENOG4105EQR	Transposase IS116 IS110 IS902
A4S02_08400	ENOG4105EW9	transcriptional regulator AsnC family
A4S02_08425	ENOG4105D0D	Nitrate reductase 2, gamma subunit
A4S02_08430	ENOG4105R3A	Nitrate reductase
A4S02_08435	ENOG4108IUE	nitrate reductase beta subunit
A4S02_08440	ENOG4105CRU	nitrate reductase, alpha subunit
A4S02_08475	ENOG4107QZF	nitrite reductase NADPH large subunit
A4S02_08480	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
A4S02_08490	ENOG4105D7T	ABC transporter
A4S02_08505	ENOG4106WF9	DNA-binding transcriptional regulator TorR
A4S02_08525	ENOG4105EQR	Transposase IS116 IS110 IS902
A4S02_08540	ENOG4105KVH	Transcriptional regulator
A4S02_08545	ENOG4105CJ3	phosphate transporter
A4S02_08550	ENOG4105KPV	Transcriptional regulator
A4S02_08555	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
A4S02_08560	ENOG4105K78	MarR family Transcriptional regulator
A4S02_08590	ENOG4105EQR	Transposase IS116 IS110 IS902
A4S02_08705	ENOG4105M6F	mutator MutT protein
A4S02_08755	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
A4S02_08765	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
A4S02_08770	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
A4S02_08775	ENOG41081BE	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
A4S02_08780	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
A4S02_08785	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
A4S02_08795	ENOG4105C75	arginyL-tRNA synthetase
A4S02_08800	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
A4S02_08805	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
A4S02_08810	ENOG4105CGK	Exodeoxyribonuclease III
A4S02_08815	ENOG4106HB6	Alpha beta hydrolase
A4S02_08835	ENOG4105JIE	May be involved in the transport of PQQ or its precursor to the periplasm (By similarity)
A4S02_08840	ENOG41086XE	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity)
A4S02_08845	ENOG4105Z85	coenzyme PQQ synthesis
A4S02_08850	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
A4S02_08860	ENOG4108S10	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
A4S02_08870	ENOG4105CHM	Aminotransferase
A4S02_08875	ENOG4105D6E	homoserine dehydrogenase
A4S02_08880	ENOG4105CBT	Fructose-1,6-bisphosphatase
A4S02_08885	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
A4S02_08890	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
A4S02_08900	ENOG4105EHG	Permease protein
A4S02_08905	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
A4S02_08910	ENOG4105CNG	UPF0061 protein
A4S02_08915	ENOG4105CM2	brancheD-chain amino acid aminotransferase
A4S02_08920	ENOG4105C2M	dna polymerase I
A4S02_08935	ENOG4105CSH	Transporter
A4S02_08945	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
A4S02_08970	ENOG4105C85	amino acid
A4S02_08980	ENOG4105E5H	Transposase
A4S02_08990	ENOG41061A5	transposase
A4S02_09090	ENOG4105CAU	Arsenical resistance protein, ArsH
A4S02_09095	ENOG4105H3G	oxidoreductase
A4S02_09100	ENOG4105KVH	Transcriptional regulator
A4S02_09110	ENOG4105C26	Dehydrogenase
A4S02_09115	ENOG4107QRT	dEAD DEAH box helicase
A4S02_09140	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
A4S02_09150	ENOG4105E5H	Transposase
A4S02_09160	ENOG41061A5	transposase
A4S02_09180	ENOG4105CD3	dihydroorotase
A4S02_09200	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
A4S02_09205	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
A4S02_09215	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
A4S02_09225	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
A4S02_09230	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
A4S02_09240	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
A4S02_09270	ENOG4105CF1	Alkylated DNA repair protein
A4S02_09280	ENOG41067QW	Transcriptional regulator
A4S02_09290	ENOG4108UMI	ABC transporter, permease
A4S02_09295	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
A4S02_09300	ENOG4105D01	(LipO)protein
A4S02_09305	ENOG4105CQB	FAD linked oxidase domain protein
A4S02_09310	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
A4S02_09330	ENOG41090MY	MarR family Transcriptional regulator
A4S02_09335	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
A4S02_09340	ENOG4108VQN	4-hydroxyphenylacetate 3-monooxygenase reductase
A4S02_09345	ENOG4105MP9	class II Aldolase
A4S02_09360	ENOG4105CHR	reductase
A4S02_09370	ENOG4108Q89	anthranilate 1,2-dioxygenase large subunit
A4S02_09410	ENOG4105C26	Dehydrogenase
A4S02_09420	ENOG4105JHE	Major Facilitator Superfamily
A4S02_09440	ENOG4105EQR	Transposase IS116 IS110 IS902
A4S02_09535	ENOG4105E0K	tonB-dependent siderophore receptor
A4S02_09825	ENOG4105C26	Dehydrogenase
A4S02_09870	ENOG410630Q	Methylamine utilization
A4S02_09920	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
A4S02_09975	ENOG4105E0X	reductase
A4S02_10025	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A4S02_10030	ENOG4105RD7	BadF BadG BcrA BcrD
A4S02_10035	ENOG4105E2D	ec 3.2.1.52
A4S02_10040	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
A4S02_10045	ENOG4105EHG	Permease protein
A4S02_10055	ENOG4105D05	Receptor
A4S02_10060	ENOG4105EEQ	Na H antiporter
A4S02_10070	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
A4S02_10110	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
A4S02_10150	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
A4S02_10160	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
A4S02_10165	ENOG4105E4C	Lytic transglycosylase catalytic
A4S02_10175	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
A4S02_10180	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
A4S02_10200	ENOG410901P	UPF0249 protein
A4S02_10215	ENOG4105DHP	deoxycytidine triphosphate deaminase
A4S02_10220	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
A4S02_10235	ENOG4107QR9	Iron-sulfur cluster binding protein
A4S02_10240	ENOG4107R5T	Cysteine-rich domain
A4S02_10255	ENOG4105C7K	acetolactate synthase
A4S02_10275	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
A4S02_10285	ENOG4107WK2	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
A4S02_10290	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
A4S02_10295	ENOG4105C3G	gtp-binding protein
A4S02_10300	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
A4S02_10315	ENOG4105C9M	aspartyl-trna synthetase
A4S02_10330	ENOG4105C88	aminopeptidase
A4S02_10345	ENOG4105JHE	Major Facilitator Superfamily
A4S02_10350	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
A4S02_10355	ENOG4105CR4	methylisocitrate lyase
A4S02_10360	ENOG4105BZN	citrate synthase
A4S02_10365	ENOG4105DXD	2-methylcitrate dehydratase
A4S02_10390	ENOG4105DXN	mazG family
A4S02_10705	ENOG4105Y2X	UPF0335 protein
A4S02_10815	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
A4S02_10890	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
A4S02_10925	ENOG4105DXN	mazG family
A4S02_10930	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
A4S02_10935	ENOG4105F6U	Short-chain dehydrogenase reductase Sdr
A4S02_10950	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
A4S02_10970	ENOG4105C37	(CBS) domain
A4S02_10975	ENOG4105D6F	Phosphatase
A4S02_11000	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
A4S02_11005	ENOG4105BZU	Histidine kinase
A4S02_11010	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
A4S02_11015	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
A4S02_11020	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
A4S02_11030	ENOG4107EFR	Flavocytochrome c
A4S02_11035	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
A4S02_11040	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
A4S02_11045	ENOG4107QUT	magnesium and cobalt transport protein CorA
A4S02_11065	ENOG41090R7	Ferric uptake
A4S02_11075	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
A4S02_11080	ENOG4108WRK	Transcriptional regulator
A4S02_11090	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
A4S02_11095	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
A4S02_11100	ENOG4105DXC	membrane
A4S02_11110	ENOG4105DC1	bifunctional purine biosynthesis protein purh
A4S02_11115	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
A4S02_11120	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
A4S02_11125	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
A4S02_11130	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
A4S02_11135	ENOG4105CFG	Acts as a chaperone (By similarity)
A4S02_11140	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4S02_11145	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
A4S02_11150	ENOG4105EB3	Histidine kinase
A4S02_11160	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
A4S02_11165	ENOG4108UJU	UPF0301 protein
A4S02_11170	ENOG4105CSR	polyphosphate kinase 2
A4S02_11185	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
A4S02_11190	ENOG4105DZ1	carboxypeptidase
A4S02_11195	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
A4S02_11210	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
A4S02_11230	ENOG4106HMZ	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
A4S02_11235	ENOG4105EIE	fructose-bisphosphate aldolase
A4S02_11260	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
A4S02_11265	ENOG4105D48	metallophosphoesterase
A4S02_11285	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
A4S02_11295	ENOG4107SFH	ImpB mucB samB family
A4S02_11300	ENOG4105C85	amino acid
A4S02_11310	ENOG4108RJ9	Glycosyl transferase, family 2
A4S02_11340	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
A4S02_11350	ENOG4108FN7	Aldo keto reductase
A4S02_11355	ENOG4107RK2	ADP-ribose diphosphatase NudE
A4S02_11365	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
A4S02_11400	ENOG4107RTZ	reductase
A4S02_11415	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
A4S02_11430	ENOG4108V1U	phospholipid-binding protein
A4S02_11440	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
A4S02_11445	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
A4S02_11450	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
A4S02_11460	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
A4S02_11475	ENOG4108YYQ	gCN5-related N-acetyltransferase
A4S02_11480	ENOG4105C5H	ABC transporter
A4S02_11490	ENOG4105F0N	pyrophosphate phospho-hydrolase
A4S02_11495	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
A4S02_11510	ENOG4108X7C	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
A4S02_11515	ENOG4105D3R	alkyl hydroperoxide reductase
A4S02_11550	ENOG4105FBD	synthase
A4S02_11555	ENOG4105FE1	phytoene synthase
A4S02_11565	ENOG4105EWU	Squalene--hopene cyclase
A4S02_11585	ENOG4105Y49	secretion protein, HlyD family
A4S02_11610	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
A4S02_11625	ENOG4108ZZ3	UPF0260 protein
A4S02_11680	ENOG4105EQR	Transposase IS116 IS110 IS902
A4S02_11700	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4S02_11740	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
A4S02_11745	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
A4S02_11750	ENOG4108TGR	phosphatase
A4S02_11780	ENOG4108RT7	Glycosyl transferase, family 2
A4S02_11785	ENOG4105CNU	cell division protein FtsK
A4S02_11805	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
A4S02_11815	ENOG4105C3J	Cysteine desulfurase
A4S02_11820	ENOG4105C3J	Cysteine desulfurase
A4S02_11825	ENOG4105DHZ	alpha beta
A4S02_11830	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
A4S02_11835	ENOG4105C8N	cysteinyl-tRNA synthetase
A4S02_11845	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
A4S02_11855	ENOG4105K63	Thioredoxin
A4S02_11860	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
A4S02_11870	ENOG4108E87	P-loop hydrolase UPF0079
A4S02_11875	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
A4S02_11880	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
A4S02_11890	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
A4S02_11895	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
A4S02_11905	ENOG4105KCK	Peptidoglycan-associated lipoprotein
A4S02_11910	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
A4S02_11920	ENOG4108ZZF	transport protein (ExbD)
A4S02_11925	ENOG4105E02	MotA TolQ exbB proton channel
A4S02_11930	ENOG4107YD3	Thioesterase
A4S02_11935	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
A4S02_11940	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
A4S02_11945	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
A4S02_11950	ENOG4105CDY	transcriptional regulatory protein
A4S02_11955	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
A4S02_11960	ENOG4105EIN	peptidylprolyl cis-trans isomerase
A4S02_11965	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
A4S02_11975	ENOG4105D8X	mechanosensitive ion channel
A4S02_11990	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
A4S02_12005	ENOG4105II7	pyrroline-5-carboxylate reductase
A4S02_12025	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
A4S02_12045	ENOG4108SHN	Glycosyl transferase, family 2
A4S02_12075	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
A4S02_12080	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
A4S02_12085	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
A4S02_12090	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
A4S02_12095	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
A4S02_12100	ENOG4105K59	histidine triad (HIT) protein
A4S02_12105	ENOG41069NU	Nitroreductase
A4S02_12115	ENOG4105M0C	cytoplasmic protein
A4S02_12135	ENOG4105FA0	parb-like partition protein
A4S02_12140	ENOG4107QJE	Chromosome Partitioning Protein
A4S02_12145	ENOG4107YTN	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity)
A4S02_12150	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
A4S02_12155	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
A4S02_12160	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
A4S02_12180	ENOG4108URH	decarboxylase
A4S02_12195	ENOG4108YXA	Membrane
A4S02_12200	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
A4S02_12205	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
A4S02_12210	ENOG4108UHJ	MAF-like protein
A4S02_12220	ENOG4108UPT	UPF0178 protein
A4S02_12230	ENOG4105CZQ	inner membrane transport protein YdhC
A4S02_12240	ENOG4105W49	UPF0434 protein
A4S02_12245	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
A4S02_12250	ENOG4105K63	Thioredoxin
A4S02_12280	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
A4S02_12290	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
A4S02_12300	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
A4S02_12315	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
A4S02_12320	ENOG4105C26	Dehydrogenase
A4S02_12330	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
A4S02_12335	ENOG4105W8H	transhydrogenase (subunit alpha
A4S02_12340	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
A4S02_12345	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
A4S02_12350	ENOG410612Q	succinate dehydrogenase (cytochrome b-556 subunit)
A4S02_12380	ENOG4105BZA	Phosphoglycerate kinase
A4S02_12400	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
A4S02_12410	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
A4S02_12425	ENOG4105F4R	Transcriptional regulator mode
A4S02_12430	ENOG4105DJ9	glucan biosynthesis protein
A4S02_12435	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
A4S02_12440	ENOG4105CE4	GlcNAc 6-P deacetylase
A4S02_12460	ENOG4107QMP	dna polymerase iii subunits gamma and tau
A4S02_12465	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
A4S02_12470	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
A4S02_12475	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
A4S02_12480	ENOG4105KRF	dihydroneopterin aldolase
A4S02_12490	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
A4S02_12495	ENOG4105CAT	Cytidine monophosphate kinase
A4S02_12500	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
A4S02_12515	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
A4S02_12520	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
A4S02_12525	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
A4S02_12535	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
A4S02_12565	ENOG4105CNI	cell division protein FtsW
A4S02_12570	ENOG4105CJN	penicillin-binding protein
A4S02_12590	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
A4S02_12595	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
A4S02_12605	ENOG4105C2C	drug resistance transporter, Bcr CflA
A4S02_12615	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
A4S02_12620	ENOG4105DSW	Fusaric acid resistance protein
A4S02_12630	ENOG4108RG0	uracil-dna glycosylase
A4S02_12650	ENOG4105HFZ	Membrane
A4S02_12665	ENOG4105CCU	oxidase (Subunit III)
A4S02_12670	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
A4S02_12685	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
A4S02_12700	ENOG4105ESV	Glycosyl transferase, family 4
A4S02_12710	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
A4S02_12720	ENOG4105CD3	dihydroorotase
A4S02_12725	ENOG4105DC8	reductase
A4S02_12730	ENOG4105DP0	ferredoxin-NADP reductase
A4S02_12740	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
A4S02_12745	ENOG4108RHM	integral membrane protein
A4S02_12755	ENOG4107R1I	NAD-dependent malic enzyme
A4S02_12785	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
A4S02_12790	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
A4S02_12795	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
A4S02_12800	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
A4S02_12805	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
A4S02_12810	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
A4S02_12815	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
A4S02_12835	ENOG4105C85	amino acid
A4S02_12840	ENOG4108IJ6	ABC transporter
A4S02_12845	ENOG4105ECW	sulfate abc transporter
A4S02_12850	ENOG4108I5D	sulfate abc transporter
A4S02_12865	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
A4S02_12870	ENOG4108R6W	Transcriptional regulator, ARAC family
A4S02_12875	ENOG4105CPD	ethanolamine ammonia-lyase
A4S02_12880	ENOG4107FQ9	ethanolamine ammonia-lyase
A4S02_12885	ENOG4105C85	amino acid
A4S02_12905	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
A4S02_12910	ENOG4105BZS	acriflavin resistance protein
A4S02_12915	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
A4S02_12955	ENOG4105EQR	Transposase IS116 IS110 IS902
A4S02_12985	ENOG4108UUM	single-stranded DNA-binding protein
A4S02_12990	ENOG4106H78	methyltransferase
A4S02_12995	ENOG4105FE9	pseudouridine synthase
A4S02_13000	ENOG4108Z86	Glutamine amidotransferase
A4S02_13005	ENOG4108Z6B	deaminase
A4S02_13015	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
A4S02_13025	ENOG4105D4P	Coproporphyrinogen iii oxidase
A4S02_13035	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
A4S02_13040	ENOG4105TPV	
A4S02_13045	ENOG4105C10	Electron transfer flavoprotein
A4S02_13050	ENOG4108JGH	Tetr family transcriptional regulator
A4S02_13100	ENOG4105C8T	Leucyl-tRNA synthetase
A4S02_13105	ENOG4105TXM	Domain of unknown function (DUF3576)
A4S02_13125	ENOG4105CEN	a g-specific adenine glycosylase
A4S02_13130	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
A4S02_13135	ENOG4105CSM	endonuclease III
A4S02_13140	ENOG4105BZ1	(ABC) transporter
A4S02_13150	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
A4S02_13155	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
A4S02_13160	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
A4S02_13165	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
A4S02_13185	ENOG4108JPW	Aminotransferase
A4S02_13215	ENOG4105TW1	Carbohydrate-selective porin OprB
A4S02_13240	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
A4S02_13245	ENOG4105C54	Major Facilitator superfamily
A4S02_13250	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
A4S02_13255	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
A4S02_13260	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
A4S02_13270	ENOG4107U9T	Pfam:Ribonuclease_BN
A4S02_13275	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
A4S02_13285	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
A4S02_13290	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
A4S02_13295	ENOG4107QM5	aconitate hydratase
A4S02_13300	ENOG4105CDA	abc transporter atp-binding protein
A4S02_13310	ENOG4105EXG	Transcriptional regulator
A4S02_13320	ENOG4106JDQ	ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB
A4S02_13330	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
A4S02_13345	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
A4S02_13350	ENOG4107ZGG	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
A4S02_13360	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
A4S02_13365	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
A4S02_13375	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
A4S02_13380	ENOG4107GFK	fumarate
A4S02_13395	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
A4S02_13410	ENOG4105D1F	ATP-binding protein
A4S02_13425	ENOG4105C0H	protease
A4S02_13445	ENOG4105C01	Dihydroxy-acid dehydratase
A4S02_13450	ENOG4105C8U	phosphate abc transporter
A4S02_13455	ENOG4105E2Z	phosphate ABC transporter (Permease
A4S02_13460	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
A4S02_13480	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
A4S02_13485	ENOG4108UJD	30S ribosomal protein S9
A4S02_13500	ENOG4105C1J	atp-dependent rna helicase
A4S02_13510	ENOG4108UYE	Lactoylglutathione lyase
A4S02_13515	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
A4S02_13520	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
A4S02_13525	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
A4S02_13530	ENOG4107PQ6	Inherit from NOG: atp synthase
A4S02_13555	ENOG4105CKK	Glycosyl transferase, family 2
A4S02_13560	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
A4S02_13570	ENOG4105F1S	paraquat-inducible protein a
A4S02_13575	ENOG4105DY2	Paraquat-inducible protein b
A4S02_13585	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
A4S02_13600	ENOG4105C3R	Methionine synthase
A4S02_13645	ENOG4105DY2	Paraquat-inducible protein b
A4S02_13650	ENOG4105DHJ	ABC, transporter
A4S02_13660	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
A4S02_13665	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
A4S02_13670	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
A4S02_13685	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A4S02_13690	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
A4S02_13695	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
A4S02_13705	ENOG4105EJC	lysr family transcriptional regulator
A4S02_13715	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
A4S02_13720	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
A4S02_13725	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
A4S02_13730	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
A4S02_13735	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4S02_13755	ENOG4105XRQ	Xanthine dehydrogenase accessory factor
A4S02_13765	ENOG4105C5X	domain protein
A4S02_13810	ENOG4108VHT	MarR family transcriptional regulator
A4S02_13820	ENOG4108XHQ	(2Fe-2S)-binding domain protein
A4S02_13825	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
A4S02_13835	ENOG4108UAU	isochorismatase
A4S02_13900	ENOG4105DQ6	Transposase
A4S02_13950	ENOG4105EEQ	Na H antiporter
A4S02_13965	ENOG4105CVR	type I restriction-modification system
A4S02_13975	ENOG41060A7	DNA polymerase beta domain protein region
A4S02_13980	ENOG4105EKX	Restriction modification system DNA (Specificity
A4S02_13985	ENOG4105DZR	Type I site-specific deoxyribonuclease
A4S02_14085	ENOG4105DZ2	Transcriptional regulator
A4S02_14115	ENOG4108R8Z	these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
A4S02_14160	ENOG4105DQ6	Transposase
A4S02_14260	ENOG4105DZR	Type I site-specific deoxyribonuclease
A4S02_14280	ENOG4108C33	Resolvase
A4S02_14300	ENOG4105CEC	DNA methylase N-4 N-6
A4S02_14570	ENOG41086VY	Fic/DOC family
A4S02_14615	ENOG41080HT	Transcriptional regulator, arsr family
A4S02_14640	ENOG4105VG5	Membrane
A4S02_14645	ENOG4105DUM	transcriptional regulator, lysR family