locus-tag	class	description
S101447_00001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
S101447_00002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
S101447_00003	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
S101447_00004	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
S101447_00005	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
S101447_00006	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
S101447_00008	ENOG4105CP7	Triose-phosphate isomerase
S101447_00010	ENOG4105CRQ	synthase (Component I)
S101447_00011	ENOG4105DDQ	anthranilate synthase
S101447_00012	ENOG4107QYG	anthranilate phosphoribosyltransferase
S101447_00013	ENOG4105DK0	Indole-3-glycerol phosphate synthase
S101447_00014	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
S101447_00015	ENOG4108JYK	Dehydrogenase
S101447_00016	ENOG4105CPP	Dehydrogenase, E1 component
S101447_00017	ENOG4105C7S	Dehydrogenase
S101447_00018	ENOG4107QN2	dihydrolipoyl dehydrogenase
S101447_00019	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
S101447_00022	ENOG4107TH8	cina domain protein
S101447_00024	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
S101447_00025	ENOG4108ZCF	integral membrane protein
S101447_00026	ENOG4105C83	adenylosuccinate lyase
S101447_00027	ENOG4107QPR	SAICAR synthetase
S101447_00028	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
S101447_00030	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
S101447_00031	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
S101447_00035	ENOG41082FP	UPF0102 protein
S101447_00036	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
S101447_00038	ENOG4105IPI	Membrane
S101447_00039	ENOG4105KHC	sulfurtransferase
S101447_00041	ENOG4105C0P	Mg chelatase subunit ChlI
S101447_00042	ENOG4108JQ1	Dehydrogenase
S101447_00044	ENOG4105XUA	cytochrome c
S101447_00045	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
S101447_00046	ENOG4105CQC	Prephenate dehydratase
S101447_00047	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
S101447_00048	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
S101447_00049	ENOG4105VEQ	Cold shock protein
S101447_00055	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
S101447_00057	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
S101447_00058	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
S101447_00059	ENOG4105HHA	aminodeoxychorismate lyase
S101447_00063	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
S101447_00064	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
S101447_00066	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
S101447_00069	ENOG4105C11	sulfate adenylyltransferase), subunit 2
S101447_00070	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
S101447_00072	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
S101447_00073	ENOG4107RJX	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
S101447_00074	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
S101447_00076	ENOG4105DWT	malate dehydrogenase (quinone)
S101447_00077	ENOG4108Z9K	Osmotically inducible protein
S101447_00078	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
S101447_00079	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
S101447_00080	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
S101447_00083	ENOG4105F8V	Hydrolase, tatD family
S101447_00086	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
S101447_00087	ENOG4105DZ1	carboxypeptidase
S101447_00088	ENOG4105K6T	rare lipoprotein A
S101447_00089	ENOG4105CVE	Lytic murein transglycosylase
S101447_00092	ENOG4105CUB	amino acid
S101447_00093	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
S101447_00097	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
S101447_00099	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
S101447_00100	ENOG4105CUT	histidyl-tRNA synthetase
S101447_00101	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
S101447_00103	ENOG4105EA8	2-Nitropropane dioxygenase
S101447_00104	ENOG4105CFH	Aspartokinase
S101447_00105	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
S101447_00106	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
S101447_00110	ENOG4105VW4	glutaredoxin 3
S101447_00111	ENOG4105MJ2	Competence protein
S101447_00112	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
S101447_00113	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
S101447_00117	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
S101447_00119	ENOG4105M85	Bola protein
S101447_00120	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
S101447_00123	ENOG4105DY8	decarboxylase
S101447_00124	ENOG4105DHU	Bile acid
S101447_00127	ENOG4107NKQ	Flavinator of succinate dehydrogenase
S101447_00128	ENOG4105CB5	ATP-dependent DNA helicase recG
S101447_00130	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
S101447_00134	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
S101447_00136	ENOG4105W0E	50S ribosomal protein L33
S101447_00137	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
S101447_00138	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
S101447_00139	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
S101447_00141	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
S101447_00142	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
S101447_00143	ENOG4108ZAF	Molybdopterin
S101447_00144	ENOG4105M00	molybdopterin converting factor, subunit 1
S101447_00147	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
S101447_00148	ENOG4108IGT	Dipeptidase
S101447_00151	ENOG4105CFU	surface antigen
S101447_00153	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
S101447_00155	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
S101447_00156	ENOG4105C37	(CBS) domain
S101447_00157	ENOG4108R9S	DSBA oxidoreductase
S101447_00163	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
S101447_00164	ENOG4105M4E	phosphohistidine phosphatase, SixA
S101447_00167	ENOG4107SW0	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
S101447_00168	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
S101447_00169	ENOG4105EAH	synthase
S101447_00171	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
S101447_00172	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
S101447_00174	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
S101447_00175	ENOG4107QT7	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
S101447_00177	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
S101447_00178	ENOG41082FS	50S ribosomal protein L31
S101447_00180	ENOG4108ZNX	Heat shock protein
S101447_00185	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
S101447_00186	ENOG4105W5Q	DNA repair protein (RadC
S101447_00187	ENOG4105W5Q	DNA repair protein (RadC
S101447_00189	ENOG4107RQ5	Methylates ribosomal protein L11 (By similarity)
S101447_00190	ENOG4105DC7	peptidase M24
S101447_00191	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
S101447_00194	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
S101447_00200	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
S101447_00201	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
S101447_00202	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
S101447_00203	ENOG41082BR	50S ribosomal protein L35
S101447_00204	ENOG4105DEI	Mannitol dehydrogenase
S101447_00205	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
S101447_00208	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
S101447_00209	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
S101447_00210	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
S101447_00215	ENOG4105CAK	Cell division ATP-binding protein ftsE
S101447_00218	ENOG4105C4W	S-formylglutathione hydrolase
S101447_00219	ENOG4105FFC	UPF0187 protein
S101447_00220	ENOG4108VJ1	Transcriptional regulator (CarD family
S101447_00221	ENOG4105RQ9	TPR repeat-containing protein
S101447_00223	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
S101447_00224	ENOG4105CBX	hi0933 family
S101447_00226	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
S101447_00227	ENOG4107QMS	site-determining protein
S101447_00228	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
S101447_00229	ENOG4108WYP	Transcriptional regulator
S101447_00230	ENOG4105BZ1	(ABC) transporter
S101447_00234	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
S101447_00235	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
S101447_00236	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
S101447_00237	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
S101447_00238	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
S101447_00239	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
S101447_00240	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
S101447_00242	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
S101447_00243	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
S101447_00245	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
S101447_00246	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
S101447_00247	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
S101447_00248	ENOG4105C7B	Threonine dehydratase
S101447_00249	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
S101447_00251	ENOG4105CN1	protease
S101447_00253	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
S101447_00254	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
S101447_00255	ENOG4105CW7	secretion protein, HlyD family
S101447_00256	ENOG4105BZ1	(ABC) transporter
S101447_00257	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
S101447_00259	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
S101447_00264	ENOG4105CEC	DNA methylase N-4 N-6
S101447_00265	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
S101447_00267	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
S101447_00268	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
S101447_00269	ENOG4105BZS	acriflavin resistance protein
S101447_00271	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
S101447_00274	ENOG4105D7T	ABC transporter
S101447_00275	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
S101447_00277	ENOG4108ZT0	50S ribosomal protein l17
S101447_00278	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
S101447_00279	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
S101447_00280	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S101447_00281	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
S101447_00283	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
S101447_00284	ENOG41084HQ	50S ribosomal protein L30
S101447_00285	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
S101447_00286	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
S101447_00287	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
S101447_00288	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
S101447_00289	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
S101447_00290	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S101447_00291	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
S101447_00292	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
S101447_00293	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
S101447_00294	ENOG41083MP	50s ribosomal protein l29
S101447_00295	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
S101447_00296	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
S101447_00297	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
S101447_00298	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
S101447_00299	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S101447_00300	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
S101447_00301	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
S101447_00302	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
S101447_00303	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
S101447_00304	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
S101447_00305	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
S101447_00306	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
S101447_00307	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
S101447_00308	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
S101447_00309	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
S101447_00310	ENOG4108VZM	50s ribosomal protein L10
S101447_00311	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
S101447_00312	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
S101447_00313	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
S101447_00319	ENOG4105CSH	Transporter
S101447_00321	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S101447_00327	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
S101447_00335	ENOG41060IM	Heme exporter protein
S101447_00337	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
S101447_00338	ENOG4105DA4	cytochrome c-type biogenesis protein
S101447_00339	ENOG4107QX9	Thiol disulfide interChange protein
S101447_00340	ENOG4105KWW	Biogenesis protein
S101447_00344	ENOG4105DSW	Fusaric acid resistance protein
S101447_00345	ENOG4105DSW	Fusaric acid resistance protein
S101447_00350	ENOG4105FDK	ABC transporter
S101447_00354	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
S101447_00356	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
S101447_00357	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
S101447_00358	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
S101447_00359	ENOG4105DJV	ribulose-phosphate 3-epimerase
S101447_00364	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
S101447_00365	ENOG4105E2X	shikimate dehydrogenase
S101447_00368	ENOG4105CH7	arginosuccinase
S101447_00372	ENOG4105CMR	udp-glucose 4-epimerase
S101447_00373	ENOG4108CHM	Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases
S101447_00375	ENOG4105YVS	arsR family transcriptional regulator
S101447_00376	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
S101447_00377	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
S101447_00389	ENOG4105C26	Dehydrogenase
S101447_00390	ENOG4108I6A	alcohol dehydrogenase
S101447_00391	ENOG4108WUH	Transcriptional regulator, TetR family
S101447_00393	ENOG4108RCM	Nitroreductase
S101447_00398	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
S101447_00399	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
S101447_00400	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
S101447_00401	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
S101447_00404	ENOG4105CA0	peroxidase
S101447_00405	ENOG4105CEC	DNA methylase N-4 N-6
S101447_00407	ENOG4105GCF	PGAM
S101447_00408	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
S101447_00410	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
S101447_00411	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
S101447_00412	ENOG4105D6S	protein involved in catabolism of external DNA
S101447_00415	ENOG4105DK7	lysyl-tRNA synthetase
S101447_00416	ENOG4105CEV	competence damage-inducible protein
S101447_00417	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
S101447_00418	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
S101447_00420	ENOG4105D49	3-dehydroquinate synthase
S101447_00423	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
S101447_00424	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
S101447_00425	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
S101447_00426	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
S101447_00427	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
S101447_00433	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
S101447_00436	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
S101447_00439	ENOG4107QN2	dihydrolipoyl dehydrogenase
S101447_00440	ENOG4105C7S	Dehydrogenase
S101447_00442	ENOG4105D6Z	AFG1 family ATPase
S101447_00444	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
S101447_00445	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
S101447_00446	ENOG4105CXT	aspartate transcarbamylase
S101447_00447	ENOG4105CD3	dihydroorotase
S101447_00448	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
S101447_00449	ENOG4105C79	DNA protecting protein DprA
S101447_00451	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
S101447_00452	ENOG4105CN1	protease
S101447_00457	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
S101447_00460	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
S101447_00461	ENOG4107AQZ	Membrane
S101447_00462	ENOG4105C8S	subunit m
S101447_00463	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
S101447_00465	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
S101447_00466	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
S101447_00467	ENOG4105DTN	riboflavin biosynthesis protein ribF
S101447_00468	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
S101447_00469	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
S101447_00470	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
S101447_00474	ENOG4105C8Y	Acetylornithine aminotransferase
S101447_00475	ENOG4105DBV	ornithine carbamoyltransferase
S101447_00477	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
S101447_00479	ENOG4105CQ7	ATP-dependent helicase
S101447_00481	ENOG4105CV8	reductase
S101447_00483	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
S101447_00484	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
S101447_00485	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
S101447_00490	ENOG4108WBT	adenosyltransferase
S101447_00496	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
S101447_00499	ENOG4105C26	Dehydrogenase
S101447_00501	ENOG4105C85	amino acid
S101447_00507	ENOG4105CY3	ABC transporter, permease
S101447_00508	ENOG4105DHJ	ABC, transporter
S101447_00510	ENOG4105EGS	Mechanosensitive ion channel
S101447_00513	ENOG4107SZR	mannose-6-phosphate isomerase
S101447_00514	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
S101447_00515	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
S101447_00518	ENOG4105C2N	RNA methyltransferase TrmH family group 3
S101447_00520	ENOG4105C2X	Arabinose 5-phosphate isomerase
S101447_00523	ENOG4108IUZ	ABC transporter
S101447_00524	ENOG4105QVC	MOSC domain-containing protein
S101447_00526	ENOG4107TNS	sigma 54 modulation protein ribosomal protein S30ea
S101447_00528	ENOG4108ZNX	Heat shock protein
S101447_00530	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
S101447_00531	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
S101447_00533	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
S101447_00534	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
S101447_00535	ENOG4105CAS	nag kinase
S101447_00536	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
S101447_00537	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
S101447_00538	ENOG41087PG	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
S101447_00539	ENOG4105VG0	50S ribosomal protein l34
S101447_00541	ENOG4108UYE	Lactoylglutathione lyase
S101447_00542	ENOG4105GYT	Protein of unknown function (DUF1009)
S101447_00543	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
S101447_00544	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
S101447_00545	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
S101447_00547	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S101447_00548	ENOG4105DZP	Membrane-associated zinc metalloprotease
S101447_00549	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
S101447_00551	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
S101447_00552	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
S101447_00553	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
S101447_00554	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
S101447_00555	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
S101447_00556	ENOG4105C3F	Signal peptidase i
S101447_00557	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
S101447_00558	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
S101447_00559	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
S101447_00560	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S101447_00562	ENOG4107B2H	carbonic anhydrase
S101447_00564	ENOG4105C1J	atp-dependent rna helicase
S101447_00565	ENOG4105DWV	Homoserine O-trans-acetylase
S101447_00566	ENOG4105DWV	Homoserine O-trans-acetylase
S101447_00567	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
S101447_00570	ENOG4105DZG	Dehydrogenase
S101447_00572	ENOG4105C5F	glutamine synthetase
S101447_00573	ENOG4108YZA	Nitrogen regulatory protein pii
S101447_00578	ENOG4105CAY	ferredoxin--nadp reductase
S101447_00579	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
S101447_00581	ENOG4105CI3	gtp-binding protein typa
S101447_00585	ENOG4105CA9	Pyruvate kinase
S101447_00587	ENOG4105D06	uba thif-type nad fad binding protein
S101447_00592	ENOG4105EPD	Oligopeptide transporter, Opt family
S101447_00595	ENOG4105EV9	Alpha Beta Hydrolase
S101447_00596	ENOG4105DZ0	fad dependent oxidoreductase
S101447_00597	ENOG4105PGM	cation diffusion facilitator family transporter
S101447_00600	ENOG4105CKI	cobalamin synthesis protein
S101447_00602	ENOG4105CEP	NADH dehydrogenase
S101447_00604	ENOG4105VN1	Heat shock protein
S101447_00605	ENOG4108EMS	branched-chain alpha-keto acid dehydrogenase subunit E2
S101447_00606	ENOG4105CPP	Dehydrogenase, E1 component
S101447_00607	ENOG4107R0V	Pyruvate dehydrogenase
S101447_00609	ENOG4105CJ3	phosphate transporter
S101447_00610	ENOG4105CSR	polyphosphate kinase 2
S101447_00614	ENOG4105C9K	Endothelin-converting enzyme 1
S101447_00615	ENOG4105C9K	Endothelin-converting enzyme 1
S101447_00622	ENOG4105EMU	Dehydrogenase
S101447_00623	ENOG4105KPV	Transcriptional regulator
S101447_00634	ENOG4105EEQ	Na H antiporter
S101447_00661	ENOG4105C72	UPF0176 protein
S101447_00686	ENOG4105E0K	tonB-dependent siderophore receptor
S101447_00715	ENOG4105C26	Dehydrogenase
S101447_00725	ENOG410630Q	Methylamine utilization
S101447_00731	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
S101447_00738	ENOG4105E0X	reductase
S101447_00739	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
S101447_00745	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S101447_00746	ENOG4105RD7	BadF BadG BcrA BcrD
S101447_00747	ENOG4105E2D	ec 3.2.1.52
S101447_00748	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
S101447_00749	ENOG4105EHG	Permease protein
S101447_00751	ENOG4105D05	Receptor
S101447_00752	ENOG4105EEQ	Na H antiporter
S101447_00754	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
S101447_00763	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
S101447_00773	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
S101447_00775	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
S101447_00776	ENOG4105E4C	Lytic transglycosylase catalytic
S101447_00778	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
S101447_00779	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
S101447_00783	ENOG410901P	UPF0249 protein
S101447_00786	ENOG4105DHP	deoxycytidine triphosphate deaminase
S101447_00787	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
S101447_00790	ENOG4107QR9	Iron-sulfur cluster binding protein
S101447_00791	ENOG4107R5T	Cysteine-rich domain
S101447_00794	ENOG4105C7K	acetolactate synthase
S101447_00798	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
S101447_00800	ENOG4107WK2	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
S101447_00801	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
S101447_00802	ENOG4105C3G	gtp-binding protein
S101447_00803	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
S101447_00806	ENOG4105C9M	aspartyl-trna synthetase
S101447_00809	ENOG4105C88	aminopeptidase
S101447_00812	ENOG4105JHE	Major Facilitator Superfamily
S101447_00813	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
S101447_00814	ENOG4105CR4	methylisocitrate lyase
S101447_00815	ENOG4105BZN	citrate synthase
S101447_00816	ENOG4105DXD	2-methylcitrate dehydratase
S101447_00890	ENOG4108N0N	Phage Terminase Large Subunit
S101447_00896	ENOG4105CDU	Replicative dna helicase
S101447_00925	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
S101447_00928	ENOG4105EXC	Acyl-transferase
S101447_00950	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
S101447_00952	ENOG4105DXN	mazG family
S101447_00953	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
S101447_00954	ENOG4105F6U	Short-chain dehydrogenase reductase Sdr
S101447_00957	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
S101447_00959	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
S101447_00960	ENOG4105C37	(CBS) domain
S101447_00961	ENOG4105D6F	Phosphatase
S101447_00965	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
S101447_00966	ENOG4105BZU	Histidine kinase
S101447_00967	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
S101447_00968	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
S101447_00969	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
S101447_00971	ENOG4107EFR	Flavocytochrome c
S101447_00972	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
S101447_00973	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
S101447_00974	ENOG4107QUT	magnesium and cobalt transport protein CorA
S101447_00978	ENOG41090R7	Ferric uptake
S101447_00980	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
S101447_00981	ENOG4108WRK	Transcriptional regulator
S101447_00983	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
S101447_00984	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
S101447_00985	ENOG4105DXC	membrane
S101447_00988	ENOG4105DC1	bifunctional purine biosynthesis protein purh
S101447_00989	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
S101447_00990	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
S101447_00991	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
S101447_00992	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
S101447_00993	ENOG4105CFG	Acts as a chaperone (By similarity)
S101447_00995	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S101447_00996	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
S101447_00997	ENOG4105EB3	Histidine kinase
S101447_00999	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
S101447_01000	ENOG4108UJU	UPF0301 protein
S101447_01001	ENOG4105CSR	polyphosphate kinase 2
S101447_01004	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
S101447_01005	ENOG4105DZ1	carboxypeptidase
S101447_01006	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
S101447_01009	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
S101447_01013	ENOG4106HMZ	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
S101447_01014	ENOG4105EIE	fructose-bisphosphate aldolase
S101447_01018	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
S101447_01019	ENOG4105D48	metallophosphoesterase
S101447_01020	ENOG4105M6F	mutator MutT protein
S101447_01022	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
S101447_01024	ENOG4107SFH	ImpB mucB samB family
S101447_01025	ENOG4105C85	amino acid
S101447_01027	ENOG4108RJ9	Glycosyl transferase, family 2
S101447_01033	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
S101447_01035	ENOG4108FN7	Aldo keto reductase
S101447_01036	ENOG4107RK2	ADP-ribose diphosphatase NudE
S101447_01038	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
S101447_01045	ENOG4107RTZ	reductase
S101447_01048	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
S101447_01051	ENOG4108V1U	phospholipid-binding protein
S101447_01053	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
S101447_01054	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
S101447_01055	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
S101447_01057	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
S101447_01060	ENOG4108YYQ	gCN5-related N-acetyltransferase
S101447_01061	ENOG4105C5H	ABC transporter
S101447_01063	ENOG4105F0N	pyrophosphate phospho-hydrolase
S101447_01068	ENOG4108X7C	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
S101447_01069	ENOG4105D3R	alkyl hydroperoxide reductase
S101447_01077	ENOG4105FBD	synthase
S101447_01078	ENOG4105FE1	phytoene synthase
S101447_01080	ENOG4105EWU	Squalene--hopene cyclase
S101447_01084	ENOG4105Y49	secretion protein, HlyD family
S101447_01088	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
S101447_01091	ENOG4108ZZ3	UPF0260 protein
S101447_01098	ENOG4108I7H	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
S101447_01103	ENOG4108FN7	Aldo keto reductase
S101447_01116	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
S101447_01117	ENOG4105C0Z	ABC transporter
S101447_01121	ENOG4105BZU	Histidine kinase
S101447_01122	ENOG4105EFI	regulatoR
S101447_01123	ENOG4105DCY	Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity)
S101447_01131	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
S101447_01132	ENOG4105BZS	acriflavin resistance protein
S101447_01133	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
S101447_01135	ENOG4107FQ9	ethanolamine ammonia-lyase
S101447_01136	ENOG4105CPD	ethanolamine ammonia-lyase
S101447_01137	ENOG4108R6W	Transcriptional regulator, ARAC family
S101447_01138	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
S101447_01141	ENOG4108I5D	sulfate abc transporter
S101447_01142	ENOG4105ECW	sulfate abc transporter
S101447_01143	ENOG4108IJ6	ABC transporter
S101447_01144	ENOG4105C85	amino acid
S101447_01148	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
S101447_01149	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
S101447_01150	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
S101447_01151	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
S101447_01152	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
S101447_01153	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
S101447_01154	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
S101447_01159	ENOG4107R1I	NAD-dependent malic enzyme
S101447_01161	ENOG4108RHM	integral membrane protein
S101447_01162	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
S101447_01164	ENOG4105DP0	ferredoxin-NADP reductase
S101447_01165	ENOG4105DC8	reductase
S101447_01166	ENOG4105CD3	dihydroorotase
S101447_01168	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
S101447_01170	ENOG4105ESV	Glycosyl transferase, family 4
S101447_01173	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
S101447_01176	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
S101447_01177	ENOG4105CCU	oxidase (Subunit III)
S101447_01181	ENOG4105HFZ	Membrane
S101447_01185	ENOG4108RG0	uracil-dna glycosylase
S101447_01187	ENOG4105DSW	Fusaric acid resistance protein
S101447_01188	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
S101447_01190	ENOG4105C2C	drug resistance transporter, Bcr CflA
S101447_01192	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
S101447_01193	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
S101447_01197	ENOG4105CJN	penicillin-binding protein
S101447_01198	ENOG4105CNI	cell division protein FtsW
S101447_01204	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
S101447_01206	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
S101447_01207	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
S101447_01208	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
S101447_01210	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
S101447_01211	ENOG4105CAT	Cytidine monophosphate kinase
S101447_01212	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
S101447_01214	ENOG4105KRF	dihydroneopterin aldolase
S101447_01215	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
S101447_01216	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
S101447_01217	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
S101447_01218	ENOG4107QMP	dna polymerase iii subunits gamma and tau
S101447_01221	ENOG4105CE4	GlcNAc 6-P deacetylase
S101447_01222	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
S101447_01223	ENOG4105DJ9	glucan biosynthesis protein
S101447_01224	ENOG4105F4R	Transcriptional regulator mode
S101447_01227	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
S101447_01229	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
S101447_01231	ENOG4105CV1	Transketolase (EC 2.2.1.1)
S101447_01233	ENOG4105BZA	Phosphoglycerate kinase
S101447_01239	ENOG410612Q	succinate dehydrogenase (cytochrome b-556 subunit)
S101447_01240	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
S101447_01241	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
S101447_01242	ENOG4105W8H	transhydrogenase (subunit alpha
S101447_01243	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
S101447_01245	ENOG4105C26	Dehydrogenase
S101447_01246	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
S101447_01251	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
S101447_01253	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
S101447_01259	ENOG4105K63	Thioredoxin
S101447_01260	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
S101447_01261	ENOG4105W49	UPF0434 protein
S101447_01263	ENOG4105CZQ	inner membrane transport protein YdhC
S101447_01265	ENOG4108UPT	UPF0178 protein
S101447_01267	ENOG4108UHJ	MAF-like protein
S101447_01268	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
S101447_01269	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
S101447_01270	ENOG4108YXA	Membrane
S101447_01272	ENOG4105F9N	Major Facilitator Superfamily
S101447_01273	ENOG4108URH	decarboxylase
S101447_01277	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
S101447_01278	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
S101447_01279	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
S101447_01280	ENOG4107YTN	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity)
S101447_01281	ENOG4107QJE	Chromosome Partitioning Protein
S101447_01282	ENOG4105FA0	parb-like partition protein
S101447_01286	ENOG4105M0C	cytoplasmic protein
S101447_01288	ENOG41069NU	Nitroreductase
S101447_01289	ENOG4105K59	histidine triad (HIT) protein
S101447_01290	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
S101447_01291	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
S101447_01292	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
S101447_01293	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
S101447_01294	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
S101447_01297	ENOG4108SHN	Glycosyl transferase, family 2
S101447_01301	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
S101447_01305	ENOG4105II7	pyrroline-5-carboxylate reductase
S101447_01309	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
S101447_01313	ENOG4105D8X	mechanosensitive ion channel
S101447_01315	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
S101447_01316	ENOG4105EIN	peptidylprolyl cis-trans isomerase
S101447_01317	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
S101447_01318	ENOG4105CDY	transcriptional regulatory protein
S101447_01319	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
S101447_01320	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
S101447_01321	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
S101447_01322	ENOG4107YD3	Thioesterase
S101447_01323	ENOG4105E02	MotA TolQ exbB proton channel
S101447_01324	ENOG4108ZZF	transport protein (ExbD)
S101447_01326	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
S101447_01327	ENOG4105KCK	Peptidoglycan-associated lipoprotein
S101447_01329	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
S101447_01330	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
S101447_01332	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
S101447_01333	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
S101447_01334	ENOG4108E87	P-loop hydrolase UPF0079
S101447_01336	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
S101447_01337	ENOG4105K63	Thioredoxin
S101447_01339	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
S101447_01341	ENOG4105C8N	cysteinyl-tRNA synthetase
S101447_01343	ENOG4105DHZ	alpha beta
S101447_01344	ENOG4105C3J	Cysteine desulfurase
S101447_01345	ENOG4105C3J	Cysteine desulfurase
S101447_01347	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
S101447_01351	ENOG4105CNU	cell division protein FtsK
S101447_01352	ENOG4108RT7	Glycosyl transferase, family 2
S101447_01360	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
S101447_01361	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
S101447_01365	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101447_01367	ENOG4108UUM	single-stranded DNA-binding protein
S101447_01368	ENOG4106H78	methyltransferase
S101447_01369	ENOG4105FE9	pseudouridine synthase
S101447_01370	ENOG4108Z86	Glutamine amidotransferase
S101447_01372	ENOG4108Z6B	deaminase
S101447_01374	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
S101447_01376	ENOG4105D4P	Coproporphyrinogen iii oxidase
S101447_01378	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
S101447_01379	ENOG4105TPV	
S101447_01380	ENOG4105C10	Electron transfer flavoprotein
S101447_01381	ENOG4108JGH	Tetr family transcriptional regulator
S101447_01391	ENOG4105C8T	Leucyl-tRNA synthetase
S101447_01392	ENOG4105TXM	Domain of unknown function (DUF3576)
S101447_01396	ENOG4105CEN	a g-specific adenine glycosylase
S101447_01397	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
S101447_01398	ENOG4105CSM	endonuclease III
S101447_01399	ENOG4105BZ1	(ABC) transporter
S101447_01401	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
S101447_01402	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
S101447_01403	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
S101447_01404	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
S101447_01407	ENOG4108JPW	Aminotransferase
S101447_01409	ENOG4105TW1	Carbohydrate-selective porin OprB
S101447_01412	ENOG4105TW1	Carbohydrate-selective porin OprB
S101447_01417	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
S101447_01418	ENOG4105C54	Major Facilitator superfamily
S101447_01419	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
S101447_01420	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
S101447_01421	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
S101447_01423	ENOG4107U9T	Pfam:Ribonuclease_BN
S101447_01424	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
S101447_01426	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
S101447_01427	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
S101447_01428	ENOG4107QM5	aconitate hydratase
S101447_01429	ENOG4105CDA	abc transporter atp-binding protein
S101447_01431	ENOG4105EXG	Transcriptional regulator
S101447_01433	ENOG4106JDQ	ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB
S101447_01435	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
S101447_01438	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
S101447_01439	ENOG4107ZGG	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
S101447_01441	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
S101447_01442	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
S101447_01444	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
S101447_01445	ENOG4107GFK	fumarate
S101447_01448	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
S101447_01451	ENOG4105D1F	ATP-binding protein
S101447_01454	ENOG4105C0H	protease
S101447_01456	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
S101447_01458	ENOG4105C01	Dihydroxy-acid dehydratase
S101447_01459	ENOG4105C8U	phosphate abc transporter
S101447_01460	ENOG4105E2Z	phosphate ABC transporter (Permease
S101447_01461	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
S101447_01465	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
S101447_01466	ENOG4108UJD	30S ribosomal protein S9
S101447_01469	ENOG4105C1J	atp-dependent rna helicase
S101447_01471	ENOG4108UYE	Lactoylglutathione lyase
S101447_01472	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
S101447_01473	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
S101447_01474	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
S101447_01476	ENOG4107PQ6	Inherit from NOG: atp synthase
S101447_01481	ENOG4105CKK	Glycosyl transferase, family 2
S101447_01482	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
S101447_01484	ENOG4105F1S	paraquat-inducible protein a
S101447_01485	ENOG4105DY2	Paraquat-inducible protein b
S101447_01487	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
S101447_01490	ENOG4105C3R	Methionine synthase
S101447_01499	ENOG4105DY2	Paraquat-inducible protein b
S101447_01500	ENOG4105DHJ	ABC, transporter
S101447_01502	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
S101447_01503	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
S101447_01504	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
S101447_01507	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
S101447_01508	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
S101447_01509	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
S101447_01511	ENOG4105EJC	lysr family transcriptional regulator
S101447_01513	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
S101447_01514	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
S101447_01515	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
S101447_01516	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
S101447_01517	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S101447_01521	ENOG4105XRQ	Xanthine dehydrogenase accessory factor
S101447_01523	ENOG4105C5X	domain protein
S101447_01532	ENOG4108VHT	MarR family transcriptional regulator
S101447_01533	ENOG4105MSY	salicylate hydroxylase
S101447_01534	ENOG4108XHQ	(2Fe-2S)-binding domain protein
S101447_01535	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
S101447_01537	ENOG4108UAU	isochorismatase
S101447_01539	ENOG4105RE0	Asp Glu hydantoin racemase
S101447_01540	ENOG4105CSP	Major Facilitator Superfamily
S101447_01551	ENOG4105D3R	alkyl hydroperoxide reductase
S101447_01552	ENOG41080HT	Transcriptional regulator, arsr family
S101447_01553	ENOG4108R3E	Dna-3-methyladenine glycosylase i
S101447_01555	ENOG4105KUZ	arsenate reductase
S101447_01556	ENOG4108UQY	Iron-storage protein
S101447_01562	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
S101447_01563	ENOG4108YZ9	Urea amidohydrolase subunit gamma
S101447_01564	ENOG4105KI2	Urea amidohydrolase subunit beta
S101447_01565	ENOG4105CQM	Urea amidohydrolase subunit alpha
S101447_01566	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
S101447_01567	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
S101447_01568	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
S101447_01571	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
S101447_01572	ENOG4105BZU	Histidine kinase
S101447_01574	ENOG4105C32	Amino acid ABC transporter (Permease)
S101447_01576	ENOG4105C0Z	ABC transporter
S101447_01577	ENOG4108IV0	ABC, transporter
S101447_01581	ENOG4105CSA	Coproporphyrinogen iii oxidase
S101447_01582	ENOG4105DFH	Transport of potassium into the cell (By similarity)
S101447_01583	ENOG4105DFA	alanine racemase domain protein
S101447_01584	ENOG4105EE1	crotonyl-CoA reductase
S101447_01585	ENOG4105CMQ	Chloride channel
S101447_01589	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
S101447_01590	ENOG4105E66	phosphoriboisomerase A
S101447_01591	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
S101447_01592	ENOG4108AZI	Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity)
S101447_01593	ENOG4108J5G	6-phosphogluconate dehydrogenase
S101447_01594	ENOG4108J5G	6-phosphogluconate dehydrogenase
S101447_01595	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
S101447_01598	ENOG4105CIH	Imidazole acetol-phosphate transaminase
S101447_01601	ENOG4105KK4	UPF0060 membrane protein
S101447_01606	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
S101447_01608	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
S101447_01611	ENOG4105DAA	L-lactate
S101447_01613	ENOG4105E4C	Lytic transglycosylase catalytic
S101447_01614	ENOG4107QNK	)-transporter
S101447_01617	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
S101447_01618	ENOG4105C6T	cysteine synthase
S101447_01621	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
S101447_01624	ENOG4105MYN	Zinc uptake regulation protein
S101447_01626	ENOG4105D5T	phosphonate abc transporter
S101447_01627	ENOG4105FAV	ABC, transporter
S101447_01629	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
S101447_01630	ENOG4105CGU	Enoyl-CoA hydratase
S101447_01631	ENOG4106HK8	GPR1 FUN34 yaaH family protein
S101447_01632	ENOG4105DSW	Fusaric acid resistance protein
S101447_01637	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
S101447_01639	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
S101447_01640	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
S101447_01641	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
S101447_01643	ENOG4105EFT	decarboxylase
S101447_01644	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
S101447_01645	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
S101447_01647	ENOG4105F27	Major Facilitator
S101447_01655	ENOG4105CK2	sodium dicarboxylate symporter
S101447_01659	ENOG4108ZZF	transport protein (ExbD)
S101447_01661	ENOG4108IU3	tonb-dependent siderophore receptor
S101447_01664	ENOG4107E2E	PKHD-type hydroxylase
S101447_01668	ENOG4105BZU	Histidine kinase
S101447_01674	ENOG4105E0K	tonB-dependent siderophore receptor
S101447_01676	ENOG4105DY8	decarboxylase
S101447_01677	ENOG4105F1Y	L-lysine 6-monooxygenase (NADPH)
S101447_01679	ENOG4107QJQ	Mate efflux family protein
S101447_01681	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
S101447_01682	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
S101447_01683	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
S101447_01684	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
S101447_01685	ENOG4105C8S	subunit m
S101447_01686	ENOG4105D65	subunit l
S101447_01688	ENOG4107UFS	subunit j
S101447_01689	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
S101447_01690	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
S101447_01691	ENOG4108IEH	NADH dehydrogenase subunit g
S101447_01692	ENOG4107QIZ	NADH dehydrogenase
S101447_01693	ENOG4105GKE	subunit e
S101447_01694	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
S101447_01696	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
S101447_01697	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
S101447_01698	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
S101447_01700	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
S101447_01701	ENOG4105CQB	FAD linked oxidase domain protein
S101447_01702	ENOG4105D01	(LipO)protein
S101447_01703	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
S101447_01704	ENOG4108UMI	ABC transporter, permease
S101447_01706	ENOG41067QW	Transcriptional regulator
S101447_01708	ENOG4105CF1	Alkylated DNA repair protein
S101447_01712	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
S101447_01714	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
S101447_01715	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
S101447_01717	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
S101447_01719	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
S101447_01720	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
S101447_01722	ENOG4105DFP	Integrase
S101447_01739	ENOG4105DHQ	Histidine kinase
S101447_01743	ENOG4105MP0	transposase
S101447_01745	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
S101447_01746	ENOG4105CD3	dihydroorotase
S101447_01749	ENOG4105BZ8	glutamate synthase
S101447_01750	ENOG4107SJI	Dehydrogenase
S101447_01751	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
S101447_01752	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
S101447_01753	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
S101447_01754	ENOG41090U3	tautomerase
S101447_01756	ENOG4105DZG	Dehydrogenase
S101447_01758	ENOG4105C85	amino acid
S101447_01761	ENOG4105C4M	(Ubiquinol oxidase) subunit I
S101447_01762	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
S101447_01765	ENOG4105CSH	Transporter
S101447_01768	ENOG4105C2M	dna polymerase I
S101447_01769	ENOG4105CM2	brancheD-chain amino acid aminotransferase
S101447_01770	ENOG4105CNG	UPF0061 protein
S101447_01771	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
S101447_01772	ENOG4105EHG	Permease protein
S101447_01774	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
S101447_01775	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
S101447_01776	ENOG4105CBT	Fructose-1,6-bisphosphatase
S101447_01777	ENOG4105D6E	homoserine dehydrogenase
S101447_01778	ENOG4105CHM	Aminotransferase
S101447_01780	ENOG4108S10	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
S101447_01782	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
S101447_01783	ENOG4105Z85	coenzyme PQQ synthesis
S101447_01784	ENOG41086XE	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity)
S101447_01785	ENOG4105JIE	May be involved in the transport of PQQ or its precursor to the periplasm (By similarity)
S101447_01789	ENOG4106HB6	Alpha beta hydrolase
S101447_01790	ENOG4105CGK	Exodeoxyribonuclease III
S101447_01791	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
S101447_01792	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
S101447_01793	ENOG4105C75	arginyL-tRNA synthetase
S101447_01795	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
S101447_01796	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
S101447_01797	ENOG41081BE	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
S101447_01798	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
S101447_01799	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
S101447_01801	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
S101447_01805	ENOG4105DSW	Fusaric acid resistance protein
S101447_01806	ENOG4107RSM	transcriptional regulator
S101447_01807	ENOG4105M6F	mutator MutT protein
S101447_01831	ENOG4105E4C	Lytic transglycosylase catalytic
S101447_01834	ENOG4105KVH	Transcriptional regulator
S101447_01835	ENOG4105CHR	reductase
S101447_01836	ENOG4105C5Q	Transcriptional regulator
S101447_01863	ENOG4105VGJ	Virulence-associated protein
S101447_01864	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
S101447_01871	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
S101447_01874	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
S101447_01875	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
S101447_01876	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
S101447_01881	ENOG4105CHM	Aminotransferase
S101447_01883	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
S101447_01884	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
S101447_01887	ENOG4107R7A	Allophanate hydrolase subunit 2
S101447_01888	ENOG4105E7W	lamb ycsf family protein
S101447_01889	ENOG4105DFI	Membrane
S101447_01897	ENOG4105CC0	LysR family Transcriptional regulator
S101447_01898	ENOG4105EUB	pirin domain protein
S101447_01899	ENOG4108YYH	Nadph-dependent fmn reductase
S101447_01901	ENOG4105F27	Major Facilitator
S101447_01902	ENOG4105C26	Dehydrogenase
S101447_01903	ENOG4105CEP	NADH dehydrogenase
S101447_01904	ENOG4108WUH	Transcriptional regulator, TetR family
S101447_01907	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
S101447_01912	ENOG4105CXG	d-lactate dehydrogenase
S101447_01918	ENOG4105VYE	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
S101447_01920	ENOG4108Z03	MAF-like protein
S101447_01921	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
S101447_01922	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
S101447_01923	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
S101447_01924	ENOG4105C03	ribonuclease
S101447_01925	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
S101447_01926	ENOG4105DFI	Membrane
S101447_01934	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
S101447_01935	ENOG4105CUV	Homoserine Kinase
S101447_01936	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
S101447_01939	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
S101447_01943	ENOG4105C22	threonyL-tRNA synthetase
S101447_01944	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
S101447_01946	ENOG41062D9	Histidine kinase
S101447_01947	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
S101447_01949	ENOG4105C5H	ABC transporter
S101447_01950	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
S101447_01951	ENOG4105EPH	radical SAM domain protein
S101447_01956	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
S101447_01957	ENOG4105CHM	Aminotransferase
S101447_01958	ENOG4105CHM	Aminotransferase
S101447_01961	ENOG4105M4H	endoribonuclease L-psp
S101447_01962	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
S101447_01963	ENOG4105C0B	DNA polymerase III (alpha subunit)
S101447_01968	ENOG4105CE9	30S ribosomal protein S2
S101447_01969	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
S101447_01970	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
S101447_01971	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
S101447_01972	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
S101447_01973	ENOG4105D52	delta-aminolevulinic acid dehydratase
S101447_01974	ENOG4105CUB	amino acid
S101447_01975	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
S101447_01979	ENOG4105C1J	atp-dependent rna helicase
S101447_01982	ENOG4105EAC	phosphoserine phosphatase
S101447_01983	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
S101447_01984	ENOG4105C7K	acetolactate synthase
S101447_01985	ENOG4108ZP8	Acetolactate synthase small subunit
S101447_01986	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
S101447_01988	ENOG4105E3B	Multicopper oxidase
S101447_01992	ENOG4108RWI	nicotinamidase
S101447_01993	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
S101447_01996	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
S101447_02000	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
S101447_02001	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
S101447_02002	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
S101447_02003	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
S101447_02004	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S101447_02005	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
S101447_02007	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
S101447_02008	ENOG4108UFP	Essential cell division protein (By similarity)
S101447_02009	ENOG4105CPF	Cell wall formation (By similarity)
S101447_02010	ENOG4105D4A	Cell wall formation (By similarity)
S101447_02011	ENOG4105DFU	Cell wall formation (By similarity)
S101447_02012	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
S101447_02014	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
S101447_02015	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
S101447_02017	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
S101447_02020	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
S101447_02021	ENOG4107YUR	Cell division protein mraZ
S101447_02025	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
S101447_02026	ENOG4105Y2X	UPF0335 protein
S101447_02028	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
S101447_02029	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S101447_02030	ENOG4105K46	50S ribosomal protein l27
S101447_02031	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
S101447_02038	ENOG4105C7N	Xanthine uracil vitamin C permease
S101447_02042	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
S101447_02043	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
S101447_02044	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
S101447_02045	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
S101447_02046	ENOG4108R6K	riboflavin synthase, subunit alpha
S101447_02047	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
S101447_02048	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
S101447_02054	ENOG4105Y49	secretion protein, HlyD family
S101447_02061	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
S101447_02063	ENOG4105EUJ	GTP cyclohydrolase i
S101447_02064	ENOG4105NWN	ApaG protein
S101447_02067	ENOG4105M6F	mutator MutT protein
S101447_02071	ENOG4105C25	Primosomal protein n'
S101447_02072	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
S101447_02076	ENOG4105BZU	Histidine kinase
S101447_02084	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
S101447_02085	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
S101447_02088	ENOG4105DVT	helicase
S101447_02089	ENOG4105ECY	inositol monophosphatase
S101447_02090	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
S101447_02093	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
S101447_02094	ENOG4105D7W	serine acetyltransferase
S101447_02095	ENOG4108YZA	Nitrogen regulatory protein pii
S101447_02096	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
S101447_02099	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
S101447_02101	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
S101447_02110	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
S101447_02115	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
S101447_02116	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
S101447_02117	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
S101447_02120	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
S101447_02123	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
S101447_02124	ENOG4105CHH	sulfate transporter
S101447_02125	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
S101447_02126	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
S101447_02127	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
S101447_02128	ENOG4105CAQ	asparagine synthetase
S101447_02129	ENOG4107TYR	Glycosyl Transferase
S101447_02133	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
S101447_02134	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
S101447_02135	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
S101447_02136	ENOG4105D1K	glutamate--cysteine ligase
S101447_02140	ENOG4105D1H	recombination factor protein RarA
S101447_02141	ENOG4105EI2	Pseudouridine synthase
S101447_02146	ENOG4105K5M	30s ribosomal protein S16
S101447_02147	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
S101447_02148	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
S101447_02149	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
S101447_02150	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
S101447_02151	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
S101447_02152	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
S101447_02153	ENOG4105K5G	30S ribosomal protein S21
S101447_02154	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
S101447_02156	ENOG41090HR	transcriptional regulator
S101447_02157	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
S101447_02158	ENOG4105E0F	Histidine kinase
S101447_02161	ENOG41082R8	50S ribosomal protein l32
S101447_02162	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
S101447_02163	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
S101447_02164	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
S101447_02165	ENOG4105WJX	transcriptional regulator MERR family
S101447_02168	ENOG4105CJR	Integral membrane protein (MviN
S101447_02170	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
S101447_02172	ENOG4108PZW	LysR family Transcriptional regulator
S101447_02173	ENOG4105C3M	thioredoxin reductase
S101447_02174	ENOG4105F7P	transcriptional regulator AsnC family
S101447_02179	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
S101447_02180	ENOG4105BZ9	Cytochrome C oxidase, subunit I
S101447_02181	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
S101447_02185	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
S101447_02186	ENOG4105C1V	Peptidase, M16
S101447_02187	ENOG4105D98	threonine synthase
S101447_02189	ENOG4105CTD	carboxy-peptidase
S101447_02191	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
S101447_02192	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
S101447_02194	ENOG4108JJ7	ABC transporter
S101447_02196	ENOG4105KDC	50s ribosomal protein l28
S101447_02197	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
S101447_02199	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
S101447_02200	ENOG4106BRA	Membrane
S101447_02204	ENOG4105JRK	feS assembly protein SufD
S101447_02205	ENOG4105C9B	Cysteine desulfurase
S101447_02207	ENOG4105VG1	fes assembly suf system protein
S101447_02208	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
S101447_02209	ENOG4107QS4	23S rRNA
S101447_02210	ENOG4105C1J	atp-dependent rna helicase
S101447_02212	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
S101447_02214	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
S101447_02215	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
S101447_02216	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
S101447_02217	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
S101447_02218	ENOG4105K70	DNA-binding protein
S101447_02221	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
S101447_02222	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
S101447_02223	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
S101447_02224	ENOG4105GKE	subunit e
S101447_02225	ENOG4107QIZ	NADH dehydrogenase
S101447_02227	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
S101447_02228	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
S101447_02229	ENOG4105DF2	NADH dehydrogenase subunit j
S101447_02230	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
S101447_02231	ENOG4105D65	subunit l
S101447_02232	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
S101447_02233	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
S101447_02234	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
S101447_02236	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
S101447_02238	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
S101447_02242	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
S101447_02243	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
S101447_02244	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
S101447_02249	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
S101447_02252	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
S101447_02254	ENOG4107RCI	amp-dependent synthetase and ligase
S101447_02262	ENOG4108KPJ	rna polymerase sigma factor
S101447_02264	ENOG4105E0K	tonB-dependent siderophore receptor
S101447_02269	ENOG4105MP9	class II Aldolase
S101447_02273	ENOG4105CDA	abc transporter atp-binding protein
S101447_02275	ENOG4105EVZ	LysR family transcriptional regulator
S101447_02277	ENOG4107TUM	Amidinotransferase
S101447_02278	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
S101447_02279	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
S101447_02283	ENOG4108JJA	ABC, transporter
S101447_02284	ENOG4108MBX	Secretion Protein
S101447_02287	ENOG4105CKI	cobalamin synthesis protein
S101447_02289	ENOG4105CPT	Alpha beta hydrolase
S101447_02293	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
S101447_02296	ENOG4105CHR	reductase
S101447_02298	ENOG4105F6U	Short-chain dehydrogenase reductase Sdr
S101447_02301	ENOG4105CFN	oxalyl-CoA decarboxylase
S101447_02306	ENOG4108Z9Z	response to DNA damage stimulus
S101447_02311	ENOG4105DQ4	alcohol dehydrogenase
S101447_02312	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
S101447_02314	ENOG4105DDW	LysR family Transcriptional regulator
S101447_02315	ENOG4105C5H	ABC transporter
S101447_02323	ENOG4105CEB	Aspartate aminotransferase
S101447_02324	ENOG4105HDK	L-asparaginase
S101447_02327	ENOG4108ESX	Receptor
S101447_02328	ENOG4107E2E	PKHD-type hydroxylase
S101447_02329	ENOG4108JJ9	ABC, transporter
S101447_02330	ENOG4108JJ8	(ABC) transporter
S101447_02331	ENOG4105C4M	(Ubiquinol oxidase) subunit I
S101447_02332	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
S101447_02336	ENOG4105D64	Mechanosensitive ion channel
S101447_02341	ENOG4108MI0	Resistance protein
S101447_02342	ENOG4105J12	Multidrug resistance protein mdtN
S101447_02345	ENOG4105NTW	Transcriptional regulator
S101447_02348	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
S101447_02357	ENOG4105EA8	2-Nitropropane dioxygenase
S101447_02361	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
S101447_02364	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
S101447_02367	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
S101447_02370	ENOG4105C31	Tryptophanyl-tRNA synthetase
S101447_02372	ENOG4108V1T	peptidylprolyl cis-trans isomerase
S101447_02373	ENOG4105CDH	Citrulline--aspartate ligase
S101447_02374	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
S101447_02376	ENOG4105DX0	Hemolysin A
S101447_02377	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
S101447_02378	ENOG4105CTB	Polyprenyl synthetase
S101447_02379	ENOG41083BM	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
S101447_02380	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
S101447_02381	ENOG4105DKQ	ROK family
S101447_02382	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
S101447_02383	ENOG4105C9X	ppx gppa phosphatase
S101447_02385	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
S101447_02386	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
S101447_02387	ENOG4108MG3	formate dehydrogenase
S101447_02388	ENOG4105F46	Necessary for formate dehydrogenase activity (By similarity)
S101447_02389	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
S101447_02390	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
S101447_02392	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
S101447_02393	ENOG4108K3A	Glutathione S-transferase
S101447_02394	ENOG4108UI1	Probably functions as a manganese efflux pump (By similarity)
S101447_02396	ENOG4105BZ8	glutamate synthase
S101447_02398	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
S101447_02402	ENOG4105IPI	Membrane
S101447_02408	ENOG4105DZG	Dehydrogenase
S101447_02412	ENOG4105C9Q	fumarate hydratase class II
S101447_02422	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
S101447_02423	ENOG4105IE8	Alpha-ketoglutarate permease
S101447_02424	ENOG4105E9S	glutaredoxin 2
S101447_02425	ENOG4105FQ6	thiopurine methyltransferase
S101447_02426	ENOG4105CK2	sodium dicarboxylate symporter
S101447_02434	ENOG4105C7H	Helicase, RecD TraA family
S101447_02437	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
S101447_02439	ENOG4105CVR	type I restriction-modification system
S101447_02446	ENOG4105J1P	transposase, IS3 IS911 family protein
S101447_02451	ENOG4105DZR	Type I site-specific deoxyribonuclease
S101447_02456	ENOG4107SQD	Transcriptional regulator, GntR family
S101447_02464	ENOG4105H3G	oxidoreductase
S101447_02465	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
S101447_02467	ENOG4105CR8	Transcriptional regulator
S101447_02468	ENOG4107TT2	Auxin Efflux Carrier
S101447_02469	ENOG4106NZI	LysR family Transcriptional regulator
S101447_02474	ENOG4105CIR	epoxide hydrolase
S101447_02475	ENOG4105ETT	transcriptional Regulator, LysR family
S101447_02480	ENOG4105CH6	catalase
S101447_02486	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
S101447_02488	ENOG4105CT4	transporter
S101447_02493	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
S101447_02494	ENOG4105KST	dependent repressor
S101447_02496	ENOG4107RGH	Aldehyde dehydrogenase
S101447_02498	ENOG4107R4I	Periplasmic binding protein
S101447_02499	ENOG4105EHG	Permease protein
S101447_02500	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
S101447_02502	ENOG4108YNN	Heme oxygenase
S101447_02504	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
S101447_02509	ENOG4106NZI	LysR family Transcriptional regulator
S101447_02514	ENOG4105D4R	Catalyzes the desulfonation of aliphatic sulfonates (By similarity)
S101447_02517	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
S101447_02525	ENOG4105EIG	urea carboxylase-associated protein 1
S101447_02526	ENOG4105EIG	urea carboxylase-associated protein 1
S101447_02527	ENOG4105MRR	Transcriptional regulator (By similarity)
S101447_02529	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
S101447_02533	ENOG4105H3G	oxidoreductase
S101447_02534	ENOG4105C26	Dehydrogenase
S101447_02536	ENOG4105ETS	cytosine purines uracil thiamine allantoin
S101447_02538	ENOG4105CWC	Acetylornithine deacetylase
S101447_02547	ENOG4105C26	Dehydrogenase
S101447_02548	ENOG4105CSH	Transporter
S101447_02549	ENOG4105C0A	alcohol dehydrogenase
S101447_02550	ENOG4108MP6	LysR family Transcriptional regulator
S101447_02554	ENOG4106NZI	LysR family Transcriptional regulator
S101447_02555	ENOG4105DJB	Major Facilitator Superfamily
S101447_02559	ENOG4105E2B	Taurine dioxygenase
S101447_02561	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
S101447_02562	ENOG4105E2Y	ABC, transporter
S101447_02563	ENOG4108J8Z	aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein
S101447_02564	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
S101447_02568	ENOG4108KPJ	rna polymerase sigma factor
S101447_02570	ENOG4105E0K	tonB-dependent siderophore receptor
S101447_02576	ENOG4108ZZF	transport protein (ExbD)
S101447_02579	ENOG4105C57	major facilitator superfamily
S101447_02591	ENOG4105CFG	Acts as a chaperone (By similarity)
S101447_02595	ENOG4105CNM	Receptor
S101447_02598	ENOG4105DWF	phosphomethylpyrimidine kinase
S101447_02599	ENOG4105XYF	acetyltransferase
S101447_02600	ENOG4105CPN	adenine deaminase
S101447_02601	ENOG4105E2V	Glycosyltransferase 36
S101447_02603	ENOG4108YZN	class I peptide chain release factor
S101447_02605	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
S101447_02609	ENOG4105EWU	Squalene--hopene cyclase
S101447_02611	ENOG4105HMI	Membrane
S101447_02614	ENOG4105CMI	transporter
S101447_02615	ENOG4105CJ1	ABC, transporter
S101447_02616	ENOG4105D0S	secretion protein (HlyD
S101447_02622	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
S101447_02623	ENOG4107QUY	Guanine deaminase
S101447_02625	ENOG4105E1J	oxidoreductase
S101447_02628	ENOG4105VT2	5-hydroxyisourate hydrolase
S101447_02629	ENOG4105C2W	permease
S101447_02631	ENOG4105C7W	Xanthine dehydrogenase
S101447_02636	ENOG4105C5R	Aminotransferase
S101447_02640	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
S101447_02643	ENOG4105D7T	ABC transporter
S101447_02647	ENOG4105JAB	phenazine biosynthesis protein, phzf family
S101447_02649	ENOG4105C44	Serine transporter
S101447_02650	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
S101447_02654	ENOG4105C5H	ABC transporter
S101447_02655	ENOG41074H6	response regulator
S101447_02660	ENOG4108JJ9	ABC, transporter
S101447_02661	ENOG4108JJ8	(ABC) transporter
S101447_02663	ENOG4105C9U	ATP-dependent DNA helicase RecQ
S101447_02664	ENOG4105E98	transcriptional regulator DeoR family
S101447_02665	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
S101447_02666	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
S101447_02667	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
S101447_02669	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
S101447_02670	ENOG4107XZX	Involved in the transcription termination process (By similarity)
S101447_02671	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
S101447_02673	ENOG4105EMU	Dehydrogenase
S101447_02694	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
S101447_02701	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
S101447_02714	ENOG4105DFP	Integrase
S101447_02716	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
S101447_02719	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
S101447_02720	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
S101447_02722	ENOG4105F38	ABC transporter, permease
S101447_02723	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
S101447_02724	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
S101447_02725	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
S101447_02726	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
S101447_02727	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
S101447_02729	ENOG4108UUM	single-stranded DNA-binding protein
S101447_02754	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
S101447_02756	ENOG4105MZU	cell filamentation protein
S101447_02759	ENOG4105C4R	Atp-dependent dna helicase
S101447_02763	ENOG4108UUM	single-stranded DNA-binding protein
S101447_02771	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
S101447_02773	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
S101447_02774	ENOG4107QJE	Chromosome Partitioning Protein
S101447_02786	ENOG4105E1F	short-chain dehydrogenase reductase
S101447_02789	ENOG4105D94	Major Facilitator Superfamily
S101447_02799	ENOG4105CVR	type I restriction-modification system
S101447_02801	ENOG41060A7	DNA polymerase beta domain protein region
S101447_02802	ENOG4105EKX	Restriction modification system DNA (Specificity
S101447_02803	ENOG4105DZR	Type I site-specific deoxyribonuclease
S101447_02808	ENOG4108R8Z	these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
S101447_02821	ENOG4105MZU	cell filamentation protein
S101447_02824	ENOG4105Y2X	UPF0335 protein
S101447_02825	ENOG4108KHN	disulfide isomerase, thiol-disulfide oxidase
S101447_02852	ENOG4107QHF	type ii secretion system protein e
S101447_02874	ENOG4105MZG	transcriptional modulator of maze toxin, mazf
S101447_02875	ENOG4106A2Z	transcriptional regulator antitoxin, MazE
S101447_02880	ENOG4108UUM	single-stranded DNA-binding protein
S101447_02904	ENOG4105C4R	Atp-dependent dna helicase
S101447_02914	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
S101447_02921	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
S101447_02927	ENOG4108ZNX	Heat shock protein
S101447_02929	ENOG4105EQR	Transposase IS116 IS110 IS902
S101447_02940	ENOG4105MP0	transposase
S101447_02946	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
S101447_02958	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
S101447_02959	ENOG4105WAB	arsR family transcriptional regulator
S101447_02960	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
S101447_02962	ENOG4105R1U	AraC Family Transcriptional Regulator
S101447_02963	ENOG4108IND	Tetr family transcriptional regulator
S101447_02964	ENOG4105D3W	isochorismatase
S101447_02965	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
S101447_02974	ENOG4107QZF	nitrite reductase NADPH large subunit
S101447_02975	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
S101447_02985	ENOG4105CAU	Arsenical resistance protein, ArsH
S101447_02986	ENOG4105MP0	transposase
S101447_02989	ENOG4105EEQ	Na H antiporter
S101447_02990	ENOG4105K4U	addiction module toxin, RelE StbE family
S101447_02992	ENOG4105CHR	reductase
S101447_02993	ENOG4108R3E	Dna-3-methyladenine glycosylase i
S101447_02996	ENOG4105CF7	AraC family transcriptional regulator
S101447_02997	ENOG4108JUA	Transcriptional regulator
S101447_02999	ENOG4108V7B	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)
S101447_03000	ENOG4105D7T	ABC transporter
S101447_03002	ENOG4105D7T	ABC transporter
S101447_03003	ENOG4107QZF	nitrite reductase NADPH large subunit
S101447_03006	ENOG4105KVH	Transcriptional regulator
S101447_03007	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
S101447_03008	ENOG4105C26	Dehydrogenase
S101447_03009	ENOG4105DZ2	Transcriptional regulator
S101447_03020	ENOG4105CAU	Arsenical resistance protein, ArsH
S101447_03021	ENOG4105H3G	oxidoreductase
S101447_03024	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
S101447_03031	ENOG4105CVR	type I restriction-modification system
S101447_03033	ENOG41060A7	DNA polymerase beta domain protein region
S101447_03034	ENOG4105EKX	Restriction modification system DNA (Specificity
S101447_03035	ENOG4105DZR	Type I site-specific deoxyribonuclease
S101447_03039	ENOG4105MP0	transposase
S101447_03048	ENOG4105F9F	transposase
S101447_03051	ENOG4105EQR	Transposase IS116 IS110 IS902
S101447_03052	ENOG4105MP0	transposase
S101447_03056	ENOG4107SVC	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
S101447_03062	ENOG4105K4U	addiction module toxin, RelE StbE family
S101447_03064	ENOG4105MZU	cell filamentation protein
S101447_03067	ENOG4105Y2X	UPF0335 protein
S101447_03068	ENOG4108KHN	disulfide isomerase, thiol-disulfide oxidase
S101447_03103	ENOG4107QHF	type ii secretion system protein e
S101447_03115	ENOG4105K70	DNA-binding protein
S101447_03128	ENOG4108UUM	single-stranded DNA-binding protein
S101447_03147	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
S101447_03148	ENOG4105WAB	arsR family transcriptional regulator