locus-tag	class	description
S101447_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S101447_00002	COG0592	DNA-directed DNA polymerase activity
S101447_00003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S101447_00004	COG0187	DNA topoisomerase II activity
S101447_00005	COG2877	3-deoxy-8-phosphooctulonate synthase activity
S101447_00006	COG0504	CTP synthase activity
S101447_00008	COG0149	triose-phosphate isomerase activity
S101447_00010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S101447_00012	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S101447_00013	COG0134	indole-3-glycerol-phosphate synthase activity
S101447_00014	COG0315	cyclic pyranopterin monophosphate synthase activity
S101447_00015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101447_00016	COG0022	dehydrogenase e1 component
S101447_00016	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101447_00017	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101447_00018	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101447_00019	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
S101447_00022	COG1546	Belongs to the CinA family
S101447_00025	COG0861	Integral membrane protein TerC family
S101447_00026	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S101447_00027	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S101447_00028	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S101447_00030	COG0047	phosphoribosylformylglycinamidine synthase activity
S101447_00031	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S101447_00032	COG0271	Belongs to the BolA IbaG family
S101447_00033	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
S101447_00035	COG0792	nuclease activity
S101447_00038	COG0628	permease
S101447_00039	COG2897	thiosulfate sulfurtransferase activity
S101447_00041	COG0606	chelatase, subunit chli
S101447_00042	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S101447_00044	COG3474	cytochrome
S101447_00045	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
S101447_00046	COG1605	Chorismate mutase
S101447_00046	COG0077	Prephenate dehydratase
S101447_00047	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S101447_00048	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S101447_00049	COG1278	Cold shock
S101447_00055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S101447_00057	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101447_00058	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S101447_00059	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S101447_00063	COG1663	tetraacyldisaccharide 4'-kinase activity
S101447_00064	COG1519	Transferase
S101447_00066	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S101447_00069	COG0175	sulfate reduction
S101447_00070	COG0175	sulfate reduction
S101447_00072	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S101447_00073	COG0602	queuosine metabolic process
S101447_00074	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S101447_00076	COG0579	oxidoreductase
S101447_00077	COG1764	response to oxidative stress
S101447_00078	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S101447_00079	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S101447_00080	COG0259	pyridoxamine-phosphate oxidase activity
S101447_00083	COG0084	hydrolase, TatD family'
S101447_00086	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S101447_00087	COG1686	Belongs to the peptidase S11 family
S101447_00089	COG2951	lytic endotransglycosylase activity
S101447_00092	COG0531	amino acid
S101447_00093	COG1968	undecaprenyl-diphosphatase activity
S101447_00097	COG2890	protein-(glutamine-N5) methyltransferase activity
S101447_00099	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S101447_00100	COG0124	histidyl-tRNA synthetase
S101447_00101	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S101447_00103	COG2070	2-Nitropropane dioxygenase
S101447_00104	COG0527	aspartate kinase activity
S101447_00105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S101447_00106	COG2706	6-phosphogluconolactonase activity
S101447_00112	COG2226	methyltransferase
S101447_00113	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S101447_00117	COG0321	lipoyl(octanoyl) transferase activity
S101447_00119	COG0271	Belongs to the BolA IbaG family
S101447_00120	COG0484	heat shock protein binding
S101447_00123	COG0076	glutamate decarboxylase activity
S101447_00126	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S101447_00127	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
S101447_00130	COG2022	thiamine diphosphate biosynthetic process
S101447_00134	COG0148	phosphopyruvate hydratase activity
S101447_00136	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S101447_00137	COG0303	'Molybdopterin
S101447_00138	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S101447_00139	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
S101447_00139	COG4106	trans-aconitate 2-methyltransferase activity
S101447_00141	COG0156	8-amino-7-oxononanoate synthase activity
S101447_00143	COG0314	molybdopterin synthase activity
S101447_00144	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
S101447_00147	COG0322	excinuclease ABC activity
S101447_00151	COG0729	surface antigen
S101447_00153	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S101447_00155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S101447_00157	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S101447_00163	COG1605	Chorismate mutase
S101447_00163	COG0287	Prephenate dehydrogenase
S101447_00164	COG2062	phosphohistidine phosphatase, SixA
S101447_00167	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S101447_00168	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S101447_00169	COG0142	geranyltranstransferase activity
S101447_00171	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101447_00172	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101447_00172	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S101447_00174	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S101447_00175	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S101447_00177	COG1970	mechanosensitive ion channel activity
S101447_00178	COG0254	rRNA binding
S101447_00180	COG0071	Belongs to the small heat shock protein (HSP20) family
S101447_00185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S101447_00186	COG2003	Belongs to the UPF0758 family
S101447_00187	COG2003	Belongs to the UPF0758 family
S101447_00189	COG2264	protein methyltransferase activity
S101447_00190	COG0006	proline dipeptidase activity
S101447_00191	COG0473	3-isopropylmalate dehydrogenase activity
S101447_00194	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S101447_00198	COG0747	negative chemotaxis
S101447_00200	COG0072	phenylalanine-tRNA ligase activity
S101447_00200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101447_00201	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S101447_00202	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S101447_00203	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S101447_00204	COG0246	Mannitol dehydrogenase
S101447_00205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S101447_00205	COG2010	Cytochrome c
S101447_00209	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S101447_00210	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S101447_00215	COG2884	Cell division ATP-binding protein ftsE
S101447_00218	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
S101447_00219	COG3781	membrane
S101447_00220	COG1329	Transcriptional regulator
S101447_00221	COG0457	Tetratricopeptide repeat
S101447_00221	COG0859	PFAM glycosyl transferase family 9
S101447_00223	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S101447_00224	COG2081	HI0933 family
S101447_00226	COG0850	regulation of cytokinetic process
S101447_00228	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
S101447_00229	COG1802	Transcriptional regulator
S101447_00230	COG1132	(ABC) transporter
S101447_00234	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
S101447_00236	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S101447_00237	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S101447_00238	COG0359	binds to the 23S rRNA
S101447_00239	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S101447_00240	COG0360	Binds together with S18 to 16S ribosomal RNA
S101447_00242	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S101447_00245	COG0505	Belongs to the CarA family
S101447_00246	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S101447_00247	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S101447_00248	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S101447_00249	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
S101447_00251	COG0793	Belongs to the peptidase S41A family
S101447_00253	COG1051	belongs to the nudix hydrolase family
S101447_00254	COG2814	Major facilitator Superfamily
S101447_00255	COG1566	PFAM secretion protein HlyD family protein
S101447_00256	COG1132	(ABC) transporter
S101447_00257	COG0617	tRNA 3'-terminal CCA addition
S101447_00259	COG0714	Associated with various cellular activities
S101447_00264	COG2189	Belongs to the N(4) N(6)-methyltransferase family
S101447_00265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S101447_00266	COG3237	CsbD-like
S101447_00267	COG0477	Major facilitator Superfamily
S101447_00268	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S101447_00269	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S101447_00271	COG1538	Outer membrane efflux protein
S101447_00272	COG5487	UPF0391 membrane protein
S101447_00274	COG1116	anion transmembrane transporter activity
S101447_00275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S101447_00277	COG0203	ribosomal protein L17
S101447_00278	COG0202	RNA polymerase activity
S101447_00279	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S101447_00280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S101447_00281	COG0563	adenylate kinase activity
S101447_00283	COG0200	Binds to the 23S rRNA
S101447_00284	COG1841	ribosomal large subunit assembly
S101447_00285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S101447_00286	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S101447_00287	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S101447_00288	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S101447_00289	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S101447_00290	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S101447_00291	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S101447_00292	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S101447_00293	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S101447_00294	COG0255	Belongs to the universal ribosomal protein uL29 family
S101447_00295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S101447_00296	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S101447_00297	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S101447_00298	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S101447_00299	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S101447_00300	COG0089	rRNA binding
S101447_00301	COG0088	Forms part of the polypeptide exit tunnel
S101447_00302	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S101447_00303	COG0051	transcription antitermination factor activity, RNA binding
S101447_00304	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S101447_00305	COG0049	tRNA binding
S101447_00306	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S101447_00307	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S101447_00308	COG0085	RNA polymerase activity
S101447_00309	COG0222	ribosome binding
S101447_00310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S101447_00311	COG0081	regulation of translation
S101447_00312	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S101447_00319	COG0477	Major facilitator Superfamily
S101447_00321	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S101447_00327	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
S101447_00335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S101447_00337	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
S101447_00338	COG1138	Cytochrome C-type biogenesis protein
S101447_00339	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101447_00340	COG3088	subunit of a heme lyase
S101447_00344	COG1289	transmembrane transporter activity
S101447_00345	COG1289	transmembrane transporter activity
S101447_00350	COG1121	(ABC) transporter
S101447_00353	COG0248	Ppx GppA phosphatase
S101447_00354	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
S101447_00356	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S101447_00357	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S101447_00359	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S101447_00363	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S101447_00364	COG0237	dephospho-CoA kinase activity
S101447_00365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S101447_00368	COG0165	Argininosuccinate lyase
S101447_00370	COG0019	diaminopimelate decarboxylase activity
S101447_00372	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S101447_00373	COG3591	Belongs to the peptidase S1B family
S101447_00375	COG0640	Transcriptional regulator
S101447_00376	COG1902	pentaerythritol trinitrate reductase activity
S101447_00377	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S101447_00389	COG1012	belongs to the aldehyde dehydrogenase family
S101447_00390	COG1979	alcohol dehydrogenase
S101447_00391	COG1309	transcriptional regulator
S101447_00393	COG0778	Nitroreductase
S101447_00398	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S101447_00399	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S101447_00399	COG2857	Cytochrome c1
S101447_00400	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S101447_00400	COG2857	Cytochrome c1
S101447_00401	COG0408	coproporphyrinogen oxidase activity
S101447_00404	COG1858	cytochrome C peroxidase
S101447_00405	COG2189	Belongs to the N(4) N(6)-methyltransferase family
S101447_00407	COG0406	alpha-ribazole phosphatase activity
S101447_00408	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
S101447_00410	COG0181	hydroxymethylbilane synthase activity
S101447_00411	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S101447_00412	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
S101447_00415	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
S101447_00416	COG1546	Belongs to the CinA family
S101447_00416	COG1058	Belongs to the CinA family
S101447_00417	COG0825	malonyl-CoA metabolic process
S101447_00418	COG4974	Belongs to the 'phage' integrase family
S101447_00420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S101447_00421	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
S101447_00421	COG2885	chlorophyll binding
S101447_00423	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S101447_00424	COG0688	phosphatidylethanolamine metabolic process
S101447_00425	COG1183	phosphatidylcholine synthase activity
S101447_00426	COG3260	NADH ubiquinone oxidoreductase 20
S101447_00433	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101447_00436	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
S101447_00439	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101447_00440	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101447_00442	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
S101447_00443	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S101447_00444	COG2333	competence protein COMEC
S101447_00444	COG0658	competence protein
S101447_00445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S101447_00446	COG0540	Belongs to the ATCase OTCase family
S101447_00447	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S101447_00448	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S101447_00449	COG0758	DNA mediated transformation
S101447_00450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S101447_00451	COG0557	exoribonuclease II activity
S101447_00452	COG0793	Belongs to the peptidase S41A family
S101447_00455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
S101447_00455	COG2885	chlorophyll binding
S101447_00456	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101447_00457	COG1959	2 iron, 2 sulfur cluster binding
S101447_00460	COG0187	DNA topoisomerase II activity
S101447_00461	COG5006	permease, DMT superfamily
S101447_00463	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S101447_00465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S101447_00466	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S101447_00467	COG0196	riboflavin kinase activity
S101447_00468	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
S101447_00469	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
S101447_00470	COG0235	Class ii aldolase
S101447_00471	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S101447_00474	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S101447_00475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S101447_00477	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S101447_00479	COG1643	Atp-dependent helicase
S101447_00481	COG0656	L-ascorbic acid biosynthetic process
S101447_00483	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S101447_00485	COG0009	L-threonylcarbamoyladenylate synthase
S101447_00490	COG2096	Adenosyltransferase
S101447_00496	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S101447_00499	COG0506	proline dehydrogenase activity
S101447_00499	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
S101447_00499	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
S101447_00501	COG1113	amino acid transport
S101447_00507	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
S101447_00508	COG1127	ABC transporter
S101447_00510	COG3264	Mechanosensitive ion channel
S101447_00510	COG1196	nuclear chromosome segregation
S101447_00512	COG0305	Participates in initiation and elongation during chromosome replication
S101447_00513	COG2942	2-epimerase
S101447_00514	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S101447_00514	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
S101447_00515	COG0194	GDP metabolic process
S101447_00518	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S101447_00520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
S101447_00520	COG0517	IMP dehydrogenase activity
S101447_00523	COG1137	ATPase activity
S101447_00524	COG0633	Ferredoxin
S101447_00524	COG3217	Mosc domain protein beta barrel domain protein
S101447_00526	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S101447_00529	COG0242	peptide deformylase activity
S101447_00530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S101447_00531	COG0101	tRNA pseudouridine synthase activity
S101447_00533	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101447_00534	COG2171	N-acyltransferase activity
S101447_00535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S101447_00536	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S101447_00537	COG0706	membrane insertase activity
S101447_00538	COG0594	ribonuclease P activity
S101447_00539	COG0230	Belongs to the bacterial ribosomal protein bL34 family
S101447_00541	COG0346	lactoylglutathione lyase activity
S101447_00542	COG3494	Protein of unknown function (DUF1009)
S101447_00543	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S101447_00544	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S101447_00545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S101447_00548	COG0750	zinc metalloprotease
S101447_00549	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S101447_00551	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S101447_00552	COG0233	cytoplasmic translational termination
S101447_00553	COG0528	UMP kinase activity
S101447_00554	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S101447_00555	COG0571	ribonuclease III activity
S101447_00556	COG0681	Belongs to the peptidase S26 family
S101447_00557	COG0736	holo-[acyl-carrier-protein] synthase activity
S101447_00558	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S101447_00559	COG1758	RNA polymerase activity
S101447_00560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S101447_00564	COG0513	Belongs to the DEAD box helicase family
S101447_00565	COG2813	Specifically methylates the guanine in position
S101447_00565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S101447_00566	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S101447_00567	COG0481	GTPase activity
S101447_00570	COG4993	Dehydrogenase
S101447_00577	COG0538	isocitrate dehydrogenase activity
S101447_00578	COG0492	ferredoxin-NADP+ reductase activity
S101447_00579	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101447_00585	COG0469	pyruvate kinase activity
S101447_00587	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S101447_00592	COG1297	OPT oligopeptide transporter protein
S101447_00595	COG0596	Alpha beta hydrolase
S101447_00596	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
S101447_00598	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S101447_00600	COG0523	cobalamin synthesis protein
S101447_00602	COG1252	NADH dehydrogenase
S101447_00604	COG0071	Belongs to the small heat shock protein (HSP20) family
S101447_00606	COG0022	dehydrogenase e1 component
S101447_00607	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101447_00609	COG0306	phosphate transporter
S101447_00618	COG1607	acyl-coa hydrolase
S101447_00621	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S101447_00622	COG4221	oxidoreductase activity
S101447_00623	COG1959	2 iron, 2 sulfur cluster binding
S101447_00686	COG4774	siderophore transport
S101447_00715	COG1012	belongs to the aldehyde dehydrogenase family
S101447_00731	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S101447_00738	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S101447_00739	COG0415	Belongs to the DNA photolyase family
S101447_00745	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S101447_00746	COG2971	BadF BadG BcrA BcrD
S101447_00747	COG3525	Glycosyl hydrolase, family 20, catalytic domain
S101447_00748	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
S101447_00749	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101447_00751	COG4771	TonB-dependent receptor
S101447_00752	COG0025	NhaP-type Na H and K H
S101447_00754	COG1028	Short-chain dehydrogenase reductase Sdr
S101447_00763	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S101447_00773	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S101447_00775	COG1573	uracil-dna glycosylase
S101447_00776	COG0741	lytic transglycosylase activity
S101447_00777	COG1253	flavin adenine dinucleotide binding
S101447_00778	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S101447_00779	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S101447_00783	COG3394	polysaccharide catabolic process
S101447_00786	COG0717	Belongs to the dCTP deaminase family
S101447_00787	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S101447_00788	COG0697	spore germination
S101447_00790	COG1139	Iron-sulfur cluster binding protein
S101447_00791	COG0247	lactate metabolic process
S101447_00798	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S101447_00799	COG0799	negative regulation of ribosome biogenesis
S101447_00800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S101447_00801	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S101447_00802	COG0012	GTP binding
S101447_00803	COG0193	aminoacyl-tRNA hydrolase activity
S101447_00804	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S101447_00806	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S101447_00809	COG2309	aminopeptidase activity
S101447_00811	COG2319	Wd-40 repeat
S101447_00812	COG2814	Major facilitator Superfamily
S101447_00813	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S101447_00814	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S101447_00815	COG0372	Belongs to the citrate synthase family
S101447_00816	COG2079	MmgE PrpD family protein
S101447_00890	COG1783	phage Terminase large subunit
S101447_00896	COG0305	Participates in initiation and elongation during chromosome replication
S101447_00908	COG1396	sequence-specific DNA binding
S101447_00925	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
S101447_00928	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S101447_00928	COG2755	lipolytic protein G-D-S-L family
S101447_00950	COG0326	Molecular chaperone. Has ATPase activity
S101447_00952	COG3956	TIGRFAM MazG family protein
S101447_00953	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S101447_00954	COG1028	Short-chain dehydrogenase reductase Sdr
S101447_00957	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S101447_00959	COG0604	alcohol dehydrogenase
S101447_00960	COG1253	flavin adenine dinucleotide binding
S101447_00965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S101447_00967	COG0745	RESPONSE REGULATOR receiver
S101447_00968	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S101447_00969	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S101447_00971	COG0431	NADPH-dependent FMN reductase
S101447_00971	COG1053	succinate dehydrogenase
S101447_00971	COG3976	FMN-binding domain protein
S101447_00972	COG0159	tryptophan synthase activity
S101447_00973	COG0133	tryptophan synthase activity
S101447_00974	COG0598	Magnesium transport protein CorA
S101447_00976	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S101447_00980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
S101447_00981	COG1396	sequence-specific DNA binding
S101447_00983	COG0752	glycyl-tRNA synthetase alpha subunit
S101447_00985	COG0697	spore germination
S101447_00988	COG0138	bifunctional purine biosynthesis protein purh
S101447_00989	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S101447_00990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S101447_00991	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S101447_00992	COG0484	heat shock protein binding
S101447_00993	COG0443	Heat shock 70 kDa protein
S101447_00995	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S101447_00996	COG0745	RESPONSE REGULATOR receiver
S101447_00997	COG2205	protein histidine kinase activity
S101447_00999	COG1660	Displays ATPase and GTPase activities
S101447_01000	COG1678	Uncharacterized ACR, COG1678
S101447_01001	COG2326	polyphosphate kinase activity
S101447_01004	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
S101447_01005	COG1686	Belongs to the peptidase S11 family
S101447_01006	COG0024	Methionine aminopeptidase
S101447_01013	COG0352	thiamine-phosphate diphosphorylase activity
S101447_01018	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S101447_01019	COG1692	metallophosphoesterase
S101447_01020	COG0494	nUDIX hydrolase
S101447_01022	COG0167	dihydroorotate dehydrogenase activity
S101447_01024	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101447_01025	COG1113	amino acid transport
S101447_01027	COG1216	Glycosyl transferase, family 2
S101447_01031	COG0612	Peptidase, M16
S101447_01033	COG0556	nucleotide-excision repair
S101447_01035	COG0667	Aldo Keto reductase
S101447_01036	COG0494	nUDIX hydrolase
S101447_01038	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S101447_01039	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
S101447_01040	COG1877	trehalose-phosphatase activity
S101447_01045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101447_01048	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S101447_01051	COG1881	PFAM PEBP family protein
S101447_01053	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S101447_01054	COG0343	queuine tRNA-ribosyltransferase activity
S101447_01055	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S101447_01057	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
S101447_01061	COG0488	(ABC) transporter
S101447_01063	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
S101447_01068	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S101447_01069	COG0450	alkyl hydroperoxide reductase
S101447_01071	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S101447_01073	COG0287	Prephenate dehydrogenase
S101447_01075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101447_01077	COG1562	ergosterol biosynthetic process
S101447_01078	COG1562	ergosterol biosynthetic process
S101447_01079	COG1233	COG1233 Phytoene dehydrogenase and related
S101447_01080	COG1657	PFAM Prenyltransferase squalene oxidase
S101447_01084	COG1566	PFAM secretion protein HlyD family protein
S101447_01088	COG3842	ATPase activity
S101447_01091	COG2983	Belongs to the UPF0260 family
S101447_01098	COG4974	Belongs to the 'phage' integrase family
S101447_01103	COG0667	Aldo Keto reductase
S101447_01116	COG3842	ATPase activity
S101447_01117	COG0411	ABC transporter
S101447_01121	COG2198	Histidine kinase
S101447_01121	COG5002	protein histidine kinase activity
S101447_01121	COG0784	Response regulator, receiver
S101447_01122	COG0745	RESPONSE REGULATOR receiver
S101447_01123	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S101447_01130	COG1278	Cold shock
S101447_01131	COG1538	Outer membrane efflux protein
S101447_01133	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S101447_01135	COG4302	ethanolamine ammonia-lyase activity
S101447_01136	COG4303	Ethanolamine ammonia lyase large subunit
S101447_01137	COG2207	Transcriptional regulator
S101447_01138	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
S101447_01142	COG4208	sulfate ABC transporter
S101447_01143	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
S101447_01144	COG1113	amino acid transport
S101447_01147	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101447_01148	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
S101447_01149	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S101447_01150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S101447_01151	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S101447_01152	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S101447_01153	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S101447_01154	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S101447_01159	COG0281	malic enzyme
S101447_01161	COG0586	Pfam SNARE associated Golgi protein
S101447_01162	COG1028	Short-chain dehydrogenase reductase Sdr
S101447_01166	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S101447_01170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S101447_01173	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S101447_01176	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S101447_01181	COG0670	Belongs to the BI1 family
S101447_01185	COG1573	uracil-dna glycosylase
S101447_01187	COG1289	transmembrane transporter activity
S101447_01188	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101447_01190	COG2814	Major facilitator Superfamily
S101447_01192	COG1612	heme a metabolic process
S101447_01193	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S101447_01197	COG0768	penicillin binding
S101447_01198	COG0772	Belongs to the SEDS family
S101447_01205	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
S101447_01206	COG1420	regulation of RNA biosynthetic process
S101447_01207	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S101447_01208	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S101447_01210	COG0539	negative regulation of cytoplasmic translation
S101447_01211	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S101447_01212	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S101447_01214	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S101447_01216	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S101447_01217	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S101447_01221	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S101447_01223	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
S101447_01227	COG0405	Gamma-glutamyltransferase
S101447_01229	COG0156	8-amino-7-oxononanoate synthase activity
S101447_01231	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S101447_01233	COG0126	phosphoglycerate kinase activity
S101447_01236	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S101447_01238	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
S101447_01240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S101447_01241	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
S101447_01242	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
S101447_01243	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
S101447_01245	COG1012	belongs to the aldehyde dehydrogenase family
S101447_01246	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S101447_01251	COG0456	acetyltransferase
S101447_01253	COG0778	Nitroreductase
S101447_01260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S101447_01261	COG2835	tetraacyldisaccharide 4'-kinase activity
S101447_01263	COG2814	Major facilitator Superfamily
S101447_01265	COG1671	Belongs to the UPF0178 family
S101447_01267	COG0424	maF-like protein
S101447_01268	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S101447_01269	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S101447_01272	COG2814	Major facilitator Superfamily
S101447_01273	COG1611	Belongs to the LOG family
S101447_01277	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S101447_01278	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S101447_01279	COG0445	tRNA wobble uridine modification
S101447_01280	COG0357	Ribosomal RNA small subunit methyltransferase G
S101447_01281	COG1192	Involved in chromosome partitioning
S101447_01282	COG1475	DNA binding
S101447_01288	COG0778	Nitroreductase
S101447_01290	COG0140	phosphoribosyl-ATP diphosphatase activity
S101447_01291	COG0107	imidazoleglycerol-phosphate synthase activity
S101447_01292	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S101447_01293	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S101447_01294	COG0131	Imidazoleglycerol-phosphate dehydratase
S101447_01297	COG1215	transferase activity, transferring glycosyl groups
S101447_01301	COG0776	regulation of translation
S101447_01313	COG0668	transmembrane transport
S101447_01315	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S101447_01316	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S101447_01317	COG0653	protein targeting
S101447_01318	COG0217	transcriptional regulatory protein
S101447_01319	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
S101447_01320	COG0632	four-way junction helicase activity
S101447_01321	COG2255	four-way junction helicase activity
S101447_01322	COG0824	Thioesterase
S101447_01324	COG0848	biopolymer transport protein
S101447_01326	COG0823	Involved in the tonB-independent uptake of proteins
S101447_01327	COG2885	chlorophyll binding
S101447_01329	COG0037	tRNA processing
S101447_01330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S101447_01332	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S101447_01333	COG0745	RESPONSE REGULATOR receiver
S101447_01334	COG0802	atpase or kinase
S101447_01335	COG2887	Belongs to the helicase family. UvrD subfamily
S101447_01336	COG1074	ATP-dependent DNA helicase activity
S101447_01338	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S101447_01339	COG0285	dihydrofolate synthase activity
S101447_01341	COG0215	cysteine-tRNA ligase activity
S101447_01343	COG2945	thiolester hydrolase activity
S101447_01345	COG1104	cysteine desulfurase activity
S101447_01347	COG0482	sulfurtransferase activity
S101447_01350	COG0564	pseudouridine synthase activity
S101447_01351	COG1674	ftsk spoiiie
S101447_01353	COG1091	dTDP-4-dehydrorhamnose reductase activity
S101447_01354	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
S101447_01360	COG0312	modulator of DNA gyrase
S101447_01361	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S101447_01365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101447_01367	COG0629	single-stranded DNA binding
S101447_01368	COG0742	ribosomal rna small subunit methyltransferase
S101447_01369	COG1187	pseudouridine synthase activity
S101447_01370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
S101447_01372	COG0590	tRNA wobble adenosine to inosine editing
S101447_01374	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S101447_01376	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S101447_01381	COG1309	transcriptional regulator
S101447_01391	COG0495	leucyl-tRNA aminoacylation
S101447_01396	COG1194	a g-specific adenine glycosylase
S101447_01397	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S101447_01398	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S101447_01399	COG1132	(ABC) transporter
S101447_01401	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S101447_01402	COG0154	amidase activity
S101447_01403	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S101447_01404	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S101447_01407	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S101447_01417	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S101447_01418	COG2814	Major facilitator Superfamily
S101447_01419	COG0439	Biotin carboxylase
S101447_01420	COG0511	ligase activity, forming carbon-carbon bonds
S101447_01421	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S101447_01423	COG1295	ribonuclease BN
S101447_01427	COG4133	protoheme IX ABC transporter activity
S101447_01429	COG1126	abc transporter atp-binding protein
S101447_01430	COG0765	amino acid transport
S101447_01433	COG0542	response to heat
S101447_01435	COG0779	Required for maturation of 30S ribosomal subunits
S101447_01438	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S101447_01439	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S101447_01440	COG1522	sequence-specific DNA binding
S101447_01441	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S101447_01442	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101447_01445	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
S101447_01445	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
S101447_01448	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
S101447_01451	COG0489	protein tyrosine kinase activity
S101447_01454	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101447_01458	COG0129	dihydroxy-acid dehydratase activity
S101447_01459	COG0573	inorganic phosphate transmembrane transporter activity
S101447_01460	COG0581	inorganic phosphate transmembrane transporter activity
S101447_01461	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101447_01462	COG0704	Plays a role in the regulation of phosphate uptake
S101447_01465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S101447_01466	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S101447_01469	COG0513	Belongs to the DEAD box helicase family
S101447_01471	COG0346	lactoylglutathione lyase activity
S101447_01472	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S101447_01473	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S101447_01474	COG0552	protein localization to endoplasmic reticulum
S101447_01477	COG0356	it plays a direct role in the translocation of protons across the membrane
S101447_01478	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S101447_01479	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S101447_01480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S101447_01481	COG0463	Glycosyl transferase, family 2
S101447_01482	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S101447_01484	COG2995	paraquat-inducible protein a
S101447_01485	COG3008	intermembrane lipid transfer
S101447_01487	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S101447_01490	COG1410	methionine synthase
S101447_01490	COG0646	methionine synthase
S101447_01499	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
S101447_01499	COG3008	intermembrane lipid transfer
S101447_01500	COG1127	ABC transporter
S101447_01501	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
S101447_01502	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S101447_01503	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S101447_01504	COG1185	polyribonucleotide nucleotidyltransferase activity
S101447_01507	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S101447_01508	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S101447_01509	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S101447_01511	COG0583	DNA-binding transcription factor activity
S101447_01513	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S101447_01514	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S101447_01515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S101447_01516	COG0509	glycine decarboxylation via glycine cleavage system
S101447_01517	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S101447_01517	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S101447_01521	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
S101447_01523	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101447_01532	COG1846	Transcriptional regulator
S101447_01533	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S101447_01534	COG2080	2 iron, 2 sulfur cluster binding
S101447_01535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S101447_01535	COG2010	Cytochrome c
S101447_01536	COG2309	aminopeptidase activity
S101447_01537	COG1335	isochorismatase
S101447_01538	COG0596	Alpha beta hydrolase
S101447_01539	COG3473	Maleate cis-trans isomerase
S101447_01540	COG2271	Major facilitator Superfamily
S101447_01551	COG0450	alkyl hydroperoxide reductase
S101447_01552	COG0640	Transcriptional regulator
S101447_01553	COG2818	Glycosylase
S101447_01555	COG1393	Belongs to the ArsC family
S101447_01560	COG3961	Belongs to the TPP enzyme family
S101447_01561	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
S101447_01562	COG0829	nickel cation binding
S101447_01563	COG0831	urea catabolic process
S101447_01564	COG0832	Belongs to the urease beta subunit family
S101447_01565	COG0804	urea catabolic process
S101447_01566	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
S101447_01567	COG0830	nickel cation binding
S101447_01568	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
S101447_01571	COG0745	RESPONSE REGULATOR receiver
S101447_01572	COG0784	Response regulator, receiver
S101447_01572	COG2198	Histidine kinase
S101447_01572	COG5002	protein histidine kinase activity
S101447_01574	COG0559	Belongs to the binding-protein-dependent transport system permease family
S101447_01576	COG0411	ABC transporter
S101447_01577	COG0410	ABC transporter
S101447_01581	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S101447_01582	COG3158	transport of potassium into the cell
S101447_01589	COG3265	gluconokinase activity
S101447_01590	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
S101447_01591	COG0363	glucosamine-6-phosphate deaminase activity
S101447_01593	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S101447_01594	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S101447_01595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S101447_01598	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S101447_01601	COG1742	UPF0060 membrane protein
S101447_01608	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S101447_01613	COG1196	nuclear chromosome segregation
S101447_01613	COG0741	lytic transglycosylase activity
S101447_01613	COG0739	heme binding
S101447_01614	COG2814	Major facilitator Superfamily
S101447_01617	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S101447_01617	COG0519	Catalyzes the synthesis of GMP from XMP
S101447_01621	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S101447_01624	COG0735	belongs to the Fur family
S101447_01626	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
S101447_01627	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S101447_01629	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S101447_01630	COG1024	Enoyl-CoA hydratase
S101447_01631	COG1584	GPR1 FUN34 yaaH family protein
S101447_01632	COG1289	transmembrane transporter activity
S101447_01637	COG1797	cobyrinic acid a,c-diamide synthase activity
S101447_01640	COG1492	cobalamin metabolic process
S101447_01641	COG0778	Nitroreductase
S101447_01644	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
S101447_01645	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
S101447_01647	COG2814	Major facilitator Superfamily
S101447_01655	COG1301	dicarboxylic acid transport
S101447_01659	COG0848	biopolymer transport protein
S101447_01661	COG4774	siderophore transport
S101447_01664	COG3128	pkhd-type hydroxylase
S101447_01668	COG0004	ammonium transporteR
S101447_01670	COG0318	PFAM AMP-dependent synthetase and ligase
S101447_01674	COG4774	siderophore transport
S101447_01676	COG0076	glutamate decarboxylase activity
S101447_01677	COG3486	L-lysine 6-monooxygenase (NADPH) activity
S101447_01679	COG0534	Mate efflux family protein
S101447_01681	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S101447_01683	COG0517	IMP dehydrogenase activity
S101447_01683	COG0516	GMP reductase activity
S101447_01684	COG1007	ATP synthesis coupled electron transport
S101447_01686	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S101447_01687	COG0713	ATP synthesis coupled electron transport
S101447_01688	COG0839	Belongs to the complex I subunit 6 family
S101447_01689	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S101447_01690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
S101447_01691	COG1034	ATP synthesis coupled electron transport
S101447_01694	COG0649	NAD binding
S101447_01694	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S101447_01696	COG0649	NAD binding
S101447_01696	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S101447_01697	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S101447_01698	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S101447_01700	COG1648	precorrin-2 dehydrogenase activity
S101447_01700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S101447_01701	COG0277	FAD linked oxidase domain protein
S101447_01703	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S101447_01704	COG2011	ABC-type metal ion transport system permease component
S101447_01706	COG3620	sequence-specific DNA binding
S101447_01708	COG3145	DNA-N1-methyladenine dioxygenase activity
S101447_01712	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
S101447_01714	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
S101447_01715	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
S101447_01717	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
S101447_01719	COG0284	orotidine-5'-phosphate decarboxylase activity
S101447_01720	COG0135	phosphoribosylanthranilate isomerase activity
S101447_01722	COG0582	viral genome integration into host DNA
S101447_01731	COG3293	Transposase
S101447_01739	COG0642	Histidine kinase
S101447_01745	COG1953	Uracil, thiamine, allantoin
S101447_01749	COG0493	'glutamate synthase
S101447_01752	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101447_01754	COG1942	4-Oxalocrotonate Tautomerase
S101447_01756	COG4993	Dehydrogenase
S101447_01758	COG1113	amino acid transport
S101447_01761	COG1271	oxidase subunit
S101447_01762	COG1294	oxidase, subunit
S101447_01768	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101447_01768	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101447_01769	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101447_01770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
S101447_01771	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
S101447_01772	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101447_01773	COG0564	pseudouridine synthase activity
S101447_01774	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S101447_01776	COG1494	fructose-1,6-bisphosphatase
S101447_01778	COG0436	Aminotransferase
S101447_01780	COG0740	serine-type endopeptidase activity
S101447_01782	COG0535	radical SAM domain protein
S101447_01784	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
S101447_01785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S101447_01790	COG0708	Exodeoxyribonuclease III
S101447_01791	COG0316	Belongs to the HesB IscA family
S101447_01792	COG0232	Belongs to the dGTPase family. Type 2 subfamily
S101447_01793	COG0018	arginyl-trna synthetase
S101447_01795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S101447_01796	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S101447_01797	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S101447_01798	COG0805	protein transport
S101447_01799	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S101447_01801	COG4232	protein-disulfide reductase activity
S101447_01805	COG1289	transmembrane transporter activity
S101447_01806	COG0583	DNA-binding transcription factor activity
S101447_01807	COG0494	nUDIX hydrolase
S101447_01831	COG0741	lytic transglycosylase activity
S101447_01834	COG1733	regulation of RNA biosynthetic process
S101447_01835	COG1028	Short-chain dehydrogenase reductase Sdr
S101447_01843	COG4962	Type ii secretion system protein e
S101447_01844	COG3838	Conjugal transfer protein Trbc
S101447_01846	COG3451	type IV secretory pathway VirB4
S101447_01868	COG1999	signal sequence binding
S101447_01870	COG0028	Belongs to the TPP enzyme family
S101447_01871	COG1028	Short-chain dehydrogenase reductase Sdr
S101447_01874	COG0297	glycogen (starch) synthase activity
S101447_01875	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S101447_01876	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S101447_01878	COG0300	oxidoreductase activity
S101447_01884	COG0511	ligase activity, forming carbon-carbon bonds
S101447_01885	COG4221	oxidoreductase activity
S101447_01887	COG1984	allophanate hydrolase subunit 2
S101447_01888	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S101447_01889	COG0697	spore germination
S101447_01897	COG0583	DNA-binding transcription factor activity
S101447_01899	COG0431	NADPH-dependent FMN reductase
S101447_01901	COG2814	Major facilitator Superfamily
S101447_01902	COG1012	belongs to the aldehyde dehydrogenase family
S101447_01903	COG1252	NADH dehydrogenase
S101447_01904	COG1309	transcriptional regulator
S101447_01909	COG2308	Evidence 4 Homologs of previously reported genes of
S101447_01912	COG0277	FAD linked oxidase domain protein
S101447_01918	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
S101447_01920	COG0424	maF-like protein
S101447_01921	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S101447_01922	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S101447_01923	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S101447_01924	COG1530	ribonuclease E activity
S101447_01926	COG0697	spore germination
S101447_01934	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S101447_01935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101447_01936	COG0328	RNA-DNA hybrid ribonuclease activity
S101447_01943	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S101447_01944	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S101447_01946	COG3850	Histidine kinase
S101447_01946	COG0642	Histidine kinase
S101447_01947	COG0745	RESPONSE REGULATOR receiver
S101447_01949	COG0488	(ABC) transporter
S101447_01950	COG0105	UTP biosynthetic process
S101447_01951	COG1032	radical SAM domain protein
S101447_01952	COG3161	chorismate lyase activity
S101447_01956	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S101447_01961	COG0251	oxidation-reduction process
S101447_01962	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S101447_01963	COG0587	DNA-directed DNA polymerase activity
S101447_01968	COG0052	Belongs to the universal ribosomal protein uS2 family
S101447_01969	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S101447_01970	COG1381	Involved in DNA repair and RecF pathway recombination
S101447_01971	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S101447_01972	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
S101447_01973	COG0113	porphobilinogen synthase activity
S101447_01974	COG0531	amino acid
S101447_01975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S101447_01979	COG0513	Belongs to the DEAD box helicase family
S101447_01982	COG0560	Phosphoserine phosphatase
S101447_01982	COG3830	Belongs to the UPF0237 family
S101447_01983	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S101447_01984	COG0028	Belongs to the TPP enzyme family
S101447_01986	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S101447_01988	COG2132	Multicopper oxidase
S101447_01992	COG1335	isochorismatase
S101447_01993	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S101447_01996	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
S101447_02000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S101447_02001	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S101447_02001	COG0574	Belongs to the PEP-utilizing enzyme family
S101447_02002	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S101447_02003	COG0497	DNA recombination
S101447_02004	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S101447_02007	COG0849	cell division
S101447_02008	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S101447_02009	COG1181	Belongs to the D-alanine--D-alanine ligase family
S101447_02010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S101447_02011	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S101447_02012	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101447_02014	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S101447_02015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S101447_02017	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S101447_02020	COG0275	rRNA processing
S101447_02021	COG2001	Belongs to the MraZ family
S101447_02025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S101447_02026	COG3750	Belongs to the UPF0335 family
S101447_02028	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S101447_02029	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S101447_02030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S101447_02031	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S101447_02038	COG2252	PERMEase
S101447_02042	COG0723	plastoquinol--plastocyanin reductase activity
S101447_02043	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S101447_02043	COG2857	Cytochrome c1
S101447_02044	COG2857	Cytochrome c1
S101447_02044	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S101447_02045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S101447_02045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S101447_02046	COG0307	riboflavin synthase, alpha
S101447_02047	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S101447_02047	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S101447_02048	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S101447_02054	COG1566	PFAM secretion protein HlyD family protein
S101447_02061	COG0521	Mo-molybdopterin cofactor biosynthetic process
S101447_02063	COG0302	gtp cyclohydrolase
S101447_02064	COG2967	ApaG domain
S101447_02067	COG0494	nUDIX hydrolase
S101447_02072	COG4974	Belongs to the 'phage' integrase family
S101447_02076	COG0004	ammonium transporteR
S101447_02084	COG0459	protein refolding
S101447_02085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S101447_02086	COG0412	Dienelactone hydrolase
S101447_02087	COG1278	Cold shock
S101447_02088	COG1199	ATP-dependent helicase activity
S101447_02089	COG0483	inositol monophosphate 1-phosphatase activity
S101447_02090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S101447_02092	COG0586	Pfam SNARE associated Golgi protein
S101447_02093	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S101447_02095	COG0347	Belongs to the P(II) protein family
S101447_02096	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S101447_02099	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S101447_02101	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
S101447_02109	COG0463	Glycosyl transferase, family 2
S101447_02110	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S101447_02110	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S101447_02115	COG2204	response regulator
S101447_02116	COG1923	regulation of RNA biosynthetic process
S101447_02117	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S101447_02118	COG1051	belongs to the nudix hydrolase family
S101447_02120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S101447_02124	COG0659	secondary active sulfate transmembrane transporter activity
S101447_02125	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S101447_02126	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S101447_02127	COG0354	folic acid binding
S101447_02128	COG0367	asparagine synthase
S101447_02129	COG0438	transferase activity, transferring glycosyl groups
S101447_02134	COG1160	GTP binding
S101447_02135	COG2814	Major facilitator Superfamily
S101447_02136	COG3572	ergothioneine biosynthetic process
S101447_02140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S101447_02141	COG0564	pseudouridine synthase activity
S101447_02146	COG0228	four-way junction DNA binding
S101447_02147	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S101447_02148	COG0336	Belongs to the RNA methyltransferase TrmD family
S101447_02149	COG0335	large ribosomal subunit rRNA binding
S101447_02150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S101447_02151	COG0066	3-isopropylmalate dehydratase activity
S101447_02152	COG0473	3-isopropylmalate dehydrogenase activity
S101447_02153	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S101447_02154	COG0242	peptide deformylase activity
S101447_02156	COG1846	Transcriptional regulator
S101447_02157	COG0745	RESPONSE REGULATOR receiver
S101447_02158	COG2205	protein histidine kinase activity
S101447_02161	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S101447_02162	COG0416	fatty acid biosynthetic process
S101447_02163	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101447_02164	COG0776	regulation of translation
S101447_02170	COG0776	regulation of translation
S101447_02171	COG4957	zinc ion binding
S101447_02172	COG0583	DNA-binding transcription factor activity
S101447_02173	COG0492	ferredoxin-NADP+ reductase activity
S101447_02174	COG1522	sequence-specific DNA binding
S101447_02179	COG2226	methyltransferase
S101447_02181	COG0109	protoheme IX farnesyltransferase activity
S101447_02185	COG0312	modulator of DNA gyrase
S101447_02186	COG0612	Peptidase, M16
S101447_02191	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S101447_02192	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
S101447_02194	COG5265	(ABC) transporter
S101447_02196	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S101447_02197	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S101447_02199	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
S101447_02200	COG2733	membrane
S101447_02202	COG0719	Fe-S assembly protein
S101447_02203	COG0396	ATPase activity
S101447_02204	COG0719	Fe-S assembly protein
S101447_02205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S101447_02207	COG2151	metal-sulfur cluster biosynthetic enzyme
S101447_02208	COG0316	Belongs to the HesB IscA family
S101447_02209	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S101447_02210	COG0513	Belongs to the DEAD box helicase family
S101447_02212	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
S101447_02212	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S101447_02214	COG0544	peptidyl-prolyl cis-trans isomerase activity
S101447_02215	COG0740	serine-type endopeptidase activity
S101447_02216	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S101447_02218	COG0776	regulation of translation
S101447_02221	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S101447_02222	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S101447_02223	COG0649	NAD binding
S101447_02224	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
S101447_02226	COG1034	ATP synthesis coupled electron transport
S101447_02227	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
S101447_02228	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S101447_02230	COG0713	ATP synthesis coupled electron transport
S101447_02232	COG1007	ATP synthesis coupled electron transport
S101447_02234	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S101447_02236	COG0442	prolyl-tRNA aminoacylation
S101447_02238	COG1136	(ABC) transporter
S101447_02239	COG0386	Belongs to the glutathione peroxidase family
S101447_02242	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S101447_02243	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S101447_02244	COG0546	phosphoglycolate phosphatase activity
S101447_02249	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S101447_02252	COG0156	8-amino-7-oxononanoate synthase activity
S101447_02254	COG0318	PFAM AMP-dependent synthetase and ligase
S101447_02262	COG1595	DNA-templated transcription, initiation
S101447_02264	COG4774	siderophore transport
S101447_02273	COG1126	abc transporter atp-binding protein
S101447_02277	COG1834	amidinotransferase
S101447_02278	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S101447_02280	COG1231	oxidoreductase activity
S101447_02287	COG0523	cobalamin synthesis protein
S101447_02289	COG0596	Alpha beta hydrolase
S101447_02293	COG2814	Major facilitator Superfamily
S101447_02296	COG1028	Short-chain dehydrogenase reductase Sdr
S101447_02298	COG1028	Short-chain dehydrogenase reductase Sdr
S101447_02301	COG0028	Belongs to the TPP enzyme family
S101447_02306	COG3685	Protein conserved in bacteria
S101447_02311	COG1064	alcohol dehydrogenase
S101447_02314	COG0583	DNA-binding transcription factor activity
S101447_02315	COG0488	(ABC) transporter
S101447_02322	COG2985	domain, Protein
S101447_02324	COG0252	asparaginase activity
S101447_02327	COG4774	siderophore transport
S101447_02328	COG3128	pkhd-type hydroxylase
S101447_02329	COG4988	ABC transporter
S101447_02330	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S101447_02331	COG1271	oxidase subunit
S101447_02332	COG1294	oxidase, subunit
S101447_02336	COG0668	transmembrane transport
S101447_02339	COG1032	radical SAM domain protein
S101447_02341	COG1289	transmembrane transporter activity
S101447_02342	COG1566	PFAM secretion protein HlyD family protein
S101447_02345	COG1695	Transcriptional regulator
S101447_02348	COG0477	Major facilitator Superfamily
S101447_02353	COG3511	phospholipase C
S101447_02356	COG0671	phosphoesterase, PA-phosphatase related
S101447_02357	COG2070	2-Nitropropane dioxygenase
S101447_02358	COG4608	Belongs to the ABC transporter superfamily
S101447_02364	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S101447_02364	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S101447_02367	COG0745	RESPONSE REGULATOR receiver
S101447_02370	COG0180	Tryptophanyl-tRNA synthetase
S101447_02372	COG0545	Peptidyl-prolyl cis-trans isomerase
S101447_02373	COG0137	argininosuccinate synthase activity
S101447_02374	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S101447_02376	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S101447_02377	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S101447_02378	COG0142	geranyltranstransferase activity
S101447_02379	COG1722	exodeoxyribonuclease VII activity
S101447_02380	COG0425	Belongs to the sulfur carrier protein TusA family
S101447_02381	COG1940	carbohydrate kinase activity
S101447_02382	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
S101447_02385	COG0243	molybdopterin cofactor binding
S101447_02385	COG3383	formate dehydrogenase (NAD+) activity
S101447_02386	COG0437	4 iron, 4 sulfur cluster binding
S101447_02387	COG2864	formate dehydrogenase
S101447_02388	COG3058	Necessary for formate dehydrogenase activity
S101447_02389	COG0303	'Molybdopterin
S101447_02390	COG1763	Mo-molybdopterin cofactor biosynthetic process
S101447_02392	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S101447_02394	COG1971	Probably functions as a manganese efflux pump
S101447_02396	COG0493	'glutamate synthase
S101447_02397	COG0674	pyruvate-flavodoxin oxidoreductase activity
S101447_02397	COG1013	pyruvate-flavodoxin oxidoreductase activity
S101447_02397	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
S101447_02397	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
S101447_02402	COG0628	permease
S101447_02412	COG0114	fumarate hydratase activity
S101447_02422	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
S101447_02423	COG2814	Major facilitator Superfamily
S101447_02424	COG2999	glutathione oxidoreductase activity
S101447_02425	COG0500	methyltransferase
S101447_02426	COG1301	dicarboxylic acid transport
S101447_02434	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S101447_02437	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
S101447_02439	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
S101447_02451	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
S101447_02456	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101447_02461	COG2144	transferase activity, transferring acyl groups
S101447_02464	COG2072	flavoprotein involved in K transport
S101447_02466	COG1028	Short-chain dehydrogenase reductase Sdr
S101447_02467	COG0583	DNA-binding transcription factor activity
S101447_02468	COG0679	Auxin Efflux Carrier
S101447_02469	COG0583	DNA-binding transcription factor activity
S101447_02474	COG0596	Alpha beta hydrolase
S101447_02475	COG0583	DNA-binding transcription factor activity
S101447_02480	COG0753	catalase activity
S101447_02485	COG1408	metallophosphoesterase
S101447_02486	COG1902	pentaerythritol trinitrate reductase activity
S101447_02488	COG2211	Major facilitator Superfamily
S101447_02493	COG1914	H( )-stimulated, divalent metal cation uptake system
S101447_02494	COG1321	iron dependent repressor
S101447_02498	COG4558	Periplasmic binding protein
S101447_02499	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101447_02500	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
S101447_02509	COG0583	DNA-binding transcription factor activity
S101447_02514	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101447_02517	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S101447_02525	COG3665	Urea carboxylase-associated protein
S101447_02526	COG3665	Urea carboxylase-associated protein
S101447_02527	COG0864	Transcriptional regulator
S101447_02528	COG1116	anion transmembrane transporter activity
S101447_02529	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S101447_02533	COG2072	flavoprotein involved in K transport
S101447_02534	COG1012	belongs to the aldehyde dehydrogenase family
S101447_02536	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S101447_02538	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101447_02548	COG0477	Major facilitator Superfamily
S101447_02549	COG1454	alcohol dehydrogenase
S101447_02551	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
S101447_02554	COG0583	DNA-binding transcription factor activity
S101447_02555	COG2271	Major facilitator Superfamily
S101447_02559	COG2175	clavaminate synthase activity
S101447_02561	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S101447_02562	COG1116	anion transmembrane transporter activity
S101447_02563	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S101447_02564	COG1191	sigma factor activity
S101447_02568	COG1595	DNA-templated transcription, initiation
S101447_02570	COG4774	siderophore transport
S101447_02576	COG0848	biopolymer transport protein
S101447_02579	COG0477	Major facilitator Superfamily
S101447_02591	COG0443	Heat shock 70 kDa protein
S101447_02594	COG4178	(ABC) transporter
S101447_02601	COG3459	Glycosyltransferase 36 associated
S101447_02604	COG0753	catalase activity
S101447_02605	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
S101447_02609	COG1657	PFAM Prenyltransferase squalene oxidase
S101447_02611	COG2855	membrane
S101447_02612	COG0583	DNA-binding transcription factor activity
S101447_02614	COG0842	Transport permease protein
S101447_02615	COG1129	ABC transporter
S101447_02615	COG0842	Transport permease protein
S101447_02616	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S101447_02623	COG0402	S-adenosylhomocysteine deaminase activity
S101447_02625	COG2072	flavoprotein involved in K transport
S101447_02628	COG2351	hydroxyisourate hydrolase activity
S101447_02629	COG2233	PERMEase
S101447_02631	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S101447_02636	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S101447_02639	COG4206	TonB-dependent receptor
S101447_02643	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S101447_02643	COG1116	anion transmembrane transporter activity
S101447_02647	COG0384	phenazine biosynthesis protein PhzF
S101447_02649	COG0814	amino acid
S101447_02650	COG2824	Alkylphosphonate utilization operon protein PhnA
S101447_02655	COG0784	Response regulator, receiver
S101447_02660	COG4988	ABC transporter
S101447_02661	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S101447_02664	COG1349	DNA-binding transcription factor activity
S101447_02666	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S101447_02667	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S101447_02669	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S101447_02670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S101447_02671	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S101447_02672	COG0456	acetyltransferase
S101447_02673	COG4221	oxidoreductase activity
S101447_02694	COG4974	Belongs to the 'phage' integrase family
S101447_02701	COG0740	serine-type endopeptidase activity
S101447_02714	COG0582	viral genome integration into host DNA
S101447_02716	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
S101447_02719	COG0525	valine-tRNA ligase activity
S101447_02720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S101447_02722	COG1176	ABC-type spermidine putrescine transport system, permease component I
S101447_02723	COG0756	dUTP diphosphatase activity
S101447_02724	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S101447_02725	COG2226	methyltransferase
S101447_02726	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S101447_02727	COG0268	Binds directly to 16S ribosomal RNA
S101447_02729	COG0629	single-stranded DNA binding
S101447_02754	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101447_02756	COG2184	nucleotidyltransferase activity
S101447_02759	COG0210	DNA helicase
S101447_02763	COG0629	single-stranded DNA binding
S101447_02766	COG4227	nucleotidyltransferase activity
S101447_02771	COG1475	DNA binding
S101447_02773	COG1475	DNA binding
S101447_02774	COG1192	Involved in chromosome partitioning
S101447_02786	COG1028	Short-chain dehydrogenase reductase Sdr
S101447_02789	COG2814	Major facilitator Superfamily
S101447_02790	COG4977	sequence-specific DNA binding
S101447_02796	COG1999	signal sequence binding
S101447_02799	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
S101447_02801	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
S101447_02802	COG0732	type I restriction modification DNA specificity domain
S101447_02803	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
S101447_02805	COG4957	zinc ion binding
S101447_02817	COG3077	Addiction module antitoxin, RelB DinJ family
S101447_02823	COG0640	Transcriptional regulator
S101447_02824	COG3750	Belongs to the UPF0335 family
S101447_02835	COG1476	TRANSCRIPTIONal
S101447_02874	COG2337	Toxic component of a toxin-antitoxin (TA) module
S101447_02875	COG2336	PFAM SpoVT AbrB
S101447_02880	COG0629	single-stranded DNA binding
S101447_02904	COG0210	DNA helicase
S101447_02909	COG4227	nucleotidyltransferase activity
S101447_02914	COG1475	DNA binding
S101447_02916	COG2894	cell division
S101447_02919	COG3293	Transposase
S101447_02921	COG4974	Belongs to the 'phage' integrase family
S101447_02927	COG0071	Belongs to the small heat shock protein (HSP20) family
S101447_02928	COG3547	Transposase (IS116 IS110 IS902 family)
S101447_02945	COG1959	2 iron, 2 sulfur cluster binding
S101447_02946	COG1017	nitric oxide dioxygenase activity
S101447_02946	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S101447_02958	COG0604	alcohol dehydrogenase
S101447_02959	COG0640	Transcriptional regulator
S101447_02960	COG1902	pentaerythritol trinitrate reductase activity
S101447_02962	COG2207	Transcriptional regulator
S101447_02963	COG1309	transcriptional regulator
S101447_02964	COG1335	isochorismatase
S101447_02965	COG0477	Major facilitator Superfamily
S101447_02971	COG2223	nitrite transmembrane transporter activity
S101447_02974	COG2146	nitrite reductase [NAD(P)H] activity
S101447_02974	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S101447_02975	COG0243	molybdopterin cofactor binding
S101447_02977	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S101447_02977	COG1116	anion transmembrane transporter activity
S101447_02984	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S101447_02985	COG0431	NADPH-dependent FMN reductase
S101447_02990	COG2026	Addiction module toxin, RelE StbE family
S101447_02991	COG3077	Addiction module antitoxin, RelB DinJ family
S101447_02992	COG1028	Short-chain dehydrogenase reductase Sdr
S101447_02993	COG2818	Glycosylase
S101447_02996	COG2207	Transcriptional regulator
S101447_02999	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
S101447_03000	COG1116	anion transmembrane transporter activity
S101447_03001	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S101447_03002	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S101447_03002	COG1116	anion transmembrane transporter activity
S101447_03006	COG1733	regulation of RNA biosynthetic process
S101447_03007	COG1902	pentaerythritol trinitrate reductase activity
S101447_03008	COG1012	belongs to the aldehyde dehydrogenase family
S101447_03009	COG0583	DNA-binding transcription factor activity
S101447_03010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S101447_03019	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S101447_03020	COG0431	NADPH-dependent FMN reductase
S101447_03021	COG2072	flavoprotein involved in K transport
S101447_03024	COG1902	pentaerythritol trinitrate reductase activity
S101447_03025	COG0789	Transcriptional regulator
S101447_03031	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
S101447_03033	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
S101447_03034	COG0732	type I restriction modification DNA specificity domain
S101447_03035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
S101447_03043	COG4957	zinc ion binding
S101447_03048	COG2826	transposase and inactivated derivatives, IS30 family
S101447_03056	COG1570	exodeoxyribonuclease VII activity
S101447_03061	COG3077	Addiction module antitoxin, RelB DinJ family
S101447_03062	COG2026	Addiction module toxin, RelE StbE family
S101447_03066	COG0640	Transcriptional regulator
S101447_03067	COG3750	Belongs to the UPF0335 family
S101447_03078	COG1476	TRANSCRIPTIONal
S101447_03091	COG4691	Plasmid stability protein
S101447_03092	COG1487	ribonuclease activity
S101447_03093	COG1487	ribonuclease activity
S101447_03097	COG2801	Transposase and inactivated derivatives
S101447_03115	COG0776	regulation of translation
S101447_03128	COG0629	single-stranded DNA binding
S101447_03142	COG2963	transposase activity
S101447_03147	COG0604	alcohol dehydrogenase
S101447_03148	COG0640	Transcriptional regulator