locus_tag old_locus_tag gene Name start end strand product note type ID NCBI S101447_00001 S101447_00001 S101447_00001 1 1434 + Chromosomal replication initiator protein DnaA ATP-binding%3B Cytoplasm%3B DNA replication%3B DNA-binding%3B Nucleotide-binding%3B Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replicatio%3B it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids%3B Belongs to the DnaA family gene gene0 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00001 S101447_00002 S101447_00002 dnaN dnaN 1550 2674 + DNA-directed DNA polymerase Cytoplasm%3B DNA replication%3B DNA-directed DNA polymerase%3B Nucleotidyltransferase%3B Transferase%3B DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA%2C it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)%3B KEGG: apt:APA01_12310 DNA polymerase III subunit beta gene gene1 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00002 S101447_00003 S101447_00003 S101447_00003 2720 3868 + DNA replication and repair protein RecF ATP-binding%3B Cytoplasm%3B DNA damage%3B DNA repair%3B DNA replication%3B DNA-binding%3B Nucleotide-binding%3B SOS response%3B The RecF protein is involved in DNA metabolis%3B it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded%2C linear DNA. It also seems to bind ATP%3B Belongs to the RecF family gene gene2 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00003 S101447_00004 S101447_00004 gyrB gyrB 3959 6397 + DNA topoisomerase (ATP-hydrolyzing) ATP-binding%3B Cytoplasm%3B DNA-binding%3B Isomerase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Topoisomerase%3B DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings%3B Belongs to the type II topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: apt:APA01_12290 DNA gyrase subunit B gene gene3 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00004 S101447_00005 S101447_00005 kdsA kdsA 6513 7346 - 3-deoxy-8-phosphooctulonate synthase Cytoplasm%3B Lipopolysaccharide biosynthesis%3B Transferase%3B Belongs to the KdsA family%3B KEGG: apt:APA01_12280 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) gene gene4 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00005 S101447_00006 S101447_00006 pyrG pyrG 7343 8977 - CTP synthase (glutamine hydrolyzing) ATP-binding%3B Glutamine amidotransferase%3B Ligase%3B Nucleotide-binding%3B Pyrimidine biosynthesis%3B Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen%3B Belongs to the CTP synthase family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: sbw:TGUWTKB_3070 CTP synthase gene gene5 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00006 S101447_00007 S101447_00007 S101447_00007 9119 9463 - hypothetical protein gene gene6 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00007 S101447_00008 S101447_00008 tpiA tpiA 9490 10230 - Triose-phosphate isomerase Cytoplasm%3B Gluconeogenesis%3B Glycolysis%3B Isomerase%3B Pentose shunt%3B Belongs to the triosephosphate isomerase family%3B KEGG: apt:APA01_12250 triosephosphate isomerase (TIM) gene gene7 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00008 S101447_00009 S101447_00009 ppiD ppiD 10477 12396 + Peptidylprolyl isomerase KEGG: gxy:GLX_07620 peptidyl-prolyl cis-trans isomerase D gene gene8 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00009 S101447_00010 S101447_00010 trpE trpE 12393 13934 + Anthranilate synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Lyase%3B Magnesium%3B Metal-binding%3B Tryptophan biosynthesis%3B Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate%2C an intermediate in the biosynthesis of L-tryptophan. In the first step%2C the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that%2C along with chorismate%2C is used in the second step%2C catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG%2C TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity)%3B Belongs to the anthranilate synthase component I family%3B KEGG: apt:APA01_12230 anthranilate synthase component I gene gene9 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00010 S101447_00011 S101447_00011 pabA pabA 13993 14589 + Aminodeoxychorismate synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Folate biosynthesis%3B Glutamine amidotransferase%3B Lyase%3B Transferase%3B Tryptophan biosynthesis%3B Part of a heterodimeric complex that catalyzes the two- step biosynthesis of 4-amino-4-deoxychorismate (ADC)%2C a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step%2C a glutamine amidotransferase (PabA) generates ammonia as a substrate that%2C along with chorismate%2C is used in the second step%2C catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. Also involved in the biosynthesis of anthranilate%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: eco:b3360 para-aminobenzoate synthetase component II gene gene10 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00011 S101447_00012 S101447_00012 trpD trpD 14589 15701 + Anthranilate phosphoribosyltransferase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Glycosyltransferase%3B Magnesium%3B Metal-binding%3B Transferase%3B Tryptophan biosynthesis%3B Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)%3B Belongs to the anthranilate phosphoribosyltransferase family%3B KEGG: apt:APA01_12210 anthranilate phosphoribosyltransferase gene gene11 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00012 S101447_00013 S101447_00013 trpC trpC 15719 16585 + Indole-3-glycerol-phosphate synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Decarboxylase%3B Lyase%3B Tryptophan biosynthesis%3B Belongs to the TrpC family%3B KEGG: apt:APA01_12200 indole-3-glycerol phosphate synthase gene gene12 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00013 S101447_00014 S101447_00014 moaC moaC 16554 17063 + Cyclic pyranopterin phosphate synthase Molybdenum cofactor biosynthesis%3B Together with MoaA%2C is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z)%3B Belongs to the MoaC family%3B KEGG: apk:APA386B_2739 cyclic pyranopterin phosphate synthase gene gene13 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00014 S101447_00015 S101447_00015 pdhA pdhA 17191 18201 + Pyruvate dehydrogenase (acetyl-transferring) Carbohydrate metabolism%3B Glucose metabolism%3B Mitochondrion%3B Oxidoreductase%3B Phosphoprotein%3B Pyruvate%3B Thiamine pyrophosphate%3B Transit peptide%3B Tricarboxylic acid cycle%3B The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)%2C and thereby links the glycolytic pathway to the tricarboxylic cycle%3B KEGG: apt:APA01_12180 pyruvate dehydrogenase E1 component alpha subunit gene gene14 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00015 S101447_00016 S101447_00016 dlsT dlsT 18210 19565 + Dihydrolipoyllysine-residue succinyltransferase Acyltransferase%3B Lipoyl%3B Transferase%3B Tricarboxylic acid cycle%3B The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the 2-oxoacid dehydrogenase family%3B Contains 1 lipoyl-binding domain%3B KEGG: xcc:XCC1486 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) gene gene15 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00016 S101447_00017 S101447_00017 S101447_00017 19577 20827 + Dihydrolipoyllysine-residue succinyltransferase Acyltransferase%3B Lipoyl%3B Transferase%3B Tricarboxylic acid cycle%3B The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the 2-oxoacid dehydrogenase family%3B Contains 1 lipoyl-binding domain%3B KEGG: xcc:XCC1486 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) gene gene16 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00017 S101447_00018 S101447_00018 pdhD pdhD 20858 22270 + Dihydrolipoyl dehydrogenase Cell inner membrane%3B Cell membrane%3B Disulfide bond%3B FAD%3B Flavoprotein%3B Glycolysis%3B Membrane%3B NAD%3B Oxidoreductase%3B Redox-active center%3B Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: aci:ACIAD1020 dihydrolipoamide dehydrogenase gene gene17 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00018 S101447_00019 S101447_00019 lipA lipA 22392 23372 + Lipoyl synthase 4Fe-4S%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B S-adenosyl-L-methionine%3B Transferase%3B Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes%2C thereby converting the octanoylated domains into lipoylated derivatives%3B Belongs to the radical SAM superfamily. Lipoyl synthase family%3B KEGG: apt:APA01_12140 lipoic acid synthetase gene gene18 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00019 S101447_00020 S101447_00020 S101447_00020 23372 23860 + Coenzyme Q-binding protein COQ10 like protein%2C mitochondrial Membrane%3B Mitochondrion%3B Mitochondrion inner membrane%3B Transit peptide%3B Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity)%3B Belongs to the COQ10 family gene gene19 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00020 S101447_00021 S101447_00021 S101447_00021 24009 24434 + hypothetical protein gene gene20 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00021 S101447_00022 S101447_00022 pncC pncC 24492 25004 - Nicotinamide-nucleotide amidase Belongs to the CinA family%3B KEGG: apt:APA01_12110 nicotinamide-nucleotide amidase gene gene21 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00022 S101447_00023 S101447_00023 pgpA pgpA 25021 25497 - Phosphatidylglycerophosphatase KEGG: apt:APA01_12100 phosphatidylglycerophosphatase A gene gene22 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00023 S101447_00024 S101447_00024 S101447_00024 25499 27475 - Membrane-bound lytic murein transglycosylase Cell outer membrane%3B Cell wall biogenesis/degradation%3B Lipoprotein%3B Lyase%3B Membrane%3B Palmitate%3B Signal%3B Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division%3B Belongs to the transglycosylase Slt family%3B KEGG: apt:APA01_12090 soluble lytic murein transglycosylase%3B Glycosidases%2C i. e. enzymes hydrolyzing O- and S-glycosyl compounds gene gene23 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00024 S101447_00025 S101447_00025 S101447_00025 27534 28145 - putative membrane protein YjbE Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the TerC family gene gene24 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00025 S101447_00026 S101447_00026 purB purB 28317 29666 + Adenylosuccinate lyase Lyase%3B Purine biosynthesis%3B Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily%3B KEGG: gsb:GSUB_09390 adenylosuccinate lyase gene gene25 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00026 S101447_00027 S101447_00027 purC purC 29822 30589 + Phosphoribosylaminoimidazolesuccinocarboxamide synthase ATP-binding%3B Ligase%3B Nucleotide-binding%3B Purine biosynthesis%3B Belongs to the SAICAR synthetase family%3B KEGG: rbt:NOVO_04120 phosphoribosylaminoimidazole-succinocarboxamide synthase gene gene26 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00027 S101447_00028 S101447_00028 purL purL 30618 30860 + Phosphoribosylformylglycinamidine synthase ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Purine biosynthesis%3B Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL%3B Belongs to the PurS family%3B KEGG: rbt:NOVO_04125 phosphoribosylformylglycinamidine synthase gene gene27 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00028 S101447_00029 S101447_00029 S101447_00029 30857 31228 + hypothetical protein gene gene28 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00029 S101447_00030 S101447_00030 S101447_00030 31273 31926 + Phosphoribosylformylglycinamidine synthase ATP-binding%3B Cytoplasm%3B Glutamine amidotransferase%3B Hydrolase%3B Ligase%3B Nucleotide-binding%3B Purine biosynthesis%3B Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: bqu:BQ07490 phosphoribosylformylglycinamidine synthase%3B overlaps another CDS with the same product name gene gene29 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00030 S101447_00031 S101447_00031 S101447_00031 31923 34127 + Phosphoribosylformylglycinamidine synthase ATP-binding%3B Cytoplasm%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Purine biosynthesis%3B Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL%3B Belongs to the FGAMS family%3B KEGG: apt:APA01_12020 phosphoribosylformylglycinamidine synthase%3B overlaps another CDS with the same product name gene gene30 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00031 S101447_00032 S101447_00032 S101447_00032 34154 34384 + uncharacterized protein gene gene31 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00032 S101447_00033 S101447_00033 S101447_00033 34411 34749 + Glutaredoxin-4 2Fe-2S%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Redox-active center%3B Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters%3B Belongs to the glutaredoxin family. Monothiol subfamily%3B Contains 1 glutaredoxin domain gene gene32 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00033 S101447_00034 S101447_00034 S101447_00034 34822 35139 + hypothetical protein gene gene33 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00034 S101447_00035 S101447_00035 S101447_00035 35201 35668 - UPF0102 protein Belongs to the UPF0102 family gene gene34 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00035 S101447_00036 S101447_00036 S101447_00036 35793 37076 + Cardiolipin synthase Cell membrane%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Repeat%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Belongs to the phospholipase D family. Cardiolipin synthase subfamily%3B Contains 2 PLD phosphodiesterase domains%3B KEGG: apt:APA01_11980 cardiolipin synthase%3B Transferases for other substituted phosphate groups gene gene35 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00036 S101447_00037 S101447_00037 S101447_00037 37080 37763 - hypothetical protein gene gene36 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00037 S101447_00038 S101447_00038 S101447_00038 37760 38851 - UPF0118 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0118 (PerM) family gene gene37 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00038 S101447_00039 S101447_00039 mpsT mpsT 39014 39862 + Thiosulfate sulfurtransferase Alternative splicing%3B Mitochondrion%3B Pyruvate%3B Repeat%3B Transferase%3B Transit peptide%3B Catalyzes the transfer of a sulfur ion from a donor to cyanide or to other thiol compounds. Substrate preference is 3- mercaptopyruvate > thiosulfate. Involved in embryo and seed development%3B Contains 2 rhodanese domains%3B KEGG: rpx:Rpdx1_1737 thiosulfate/3-mercaptopyruvate sulfurtransferase gene gene38 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00039 S101447_00040 S101447_00040 metC metC 39859 41067 + Cystathionine beta-lyase Amino-acid biosynthesis%3B Cytoplasm%3B Lyase%3B Methionine biosynthesis%3B Pyridoxal phosphate%3B Belongs to the trans-sulfuration enzymes family%3B KEGG: apt:APA01_11930 cystathionine beta-lyase gene gene39 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00040 S101447_00041 S101447_00041 S101447_00041 41095 42606 - Competence protein ComM ATP-binding%3B Competence%3B Nucleotide-binding%3B Induced during competence development. Not needed for DNA uptake. May be involved in a recombination step. Belongs to the Mg-chelatase subunits D/I family. ComM subfamily gene gene40 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00041 S101447_00042 S101447_00042 serA serA 42609 43868 - Phosphoglycerate dehydrogenase Amino-acid biosynthesis%3B NAD%3B Oxidoreductase%3B Serine biosynthesis%3B Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B Contains 1 ACT domain%3B KEGG: apt:APA01_11910 D-3-phosphoglycerate dehydrogenase gene gene41 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00042 S101447_00043 S101447_00043 S101447_00043 43972 44769 - Inositol-phosphate phosphatase Amino-acid biosynthesis%3B Chloroplast%3B Histidine biosynthesis%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Plastid%3B Transit peptide%3B Phosphatase required for histidine production. Acts also on L-galactose 1-phosphate (L-Gal 1-P)%2C D-myoinositol 3-phosphate (D-Ins 3-P) and D-myoinositol 1-phosphate (D-Ins 1-P)%3B Belongs to the inositol monophosphatase family%3B KEGG: ppp:PHYPADRAFT_135827 inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase gene gene42 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00043 S101447_00044 S101447_00044 S101447_00044 44766 45284 - Cytochrome c Electron transport%3B Heme%3B Iron%3B Metal-binding%3B Methylation%3B Mitochondrion%3B Respiratory chain%3B Transport%3B Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex%2C the final protein carrier in the mitochondrial electron-transport chain. Belongs to the cytochrome c family gene gene43 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00044 S101447_00045 S101447_00045 kdsB kdsB 45393 46127 + 3-deoxy-manno-octulosonate cytidylyltransferase Cytoplasm%3B Lipopolysaccharide biosynthesis%3B Nucleotidyltransferase%3B Transferase%3B Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria%3B Belongs to the KdsB family%3B KEGG: apt:APA01_11880 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) gene gene44 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00045 S101447_00046 S101447_00046 S101447_00046 46135 47022 + Prephenate dehydratase Alternative splicing%3B Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Chloroplast%3B Lyase%3B Phenylalanine biosynthesis%3B Plastid%3B Transit peptide%3B Converts the prephenate produced from the shikimate- chorismate pathway into phenylalanine%3B Contains 1 ACT domain%3B Contains 1 prephenate dehydratase domain%3B KEGG: apt:APA01_11870 prephenate dehydratase gene gene45 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00046 S101447_00047 S101447_00047 dapA dapA 47033 47923 + 4-hydroxy-tetrahydrodipicolinate synthase Amino-acid biosynthesis%3B Cytoplasm%3B Diaminopimelate biosynthesis%3B Lyase%3B Lysine biosynthesis%3B Schiff base%3B Catalyzes the condensation of (S)-aspartate-beta- semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)%3B Belongs to the DapA family%3B KEGG: apt:APA01_11860 4-hydroxy-tetrahydrodipicolinate synthase gene gene46 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00047 S101447_00048 S101447_00048 S101447_00048 47923 48429 + SsrA-binding protein Cytoplasm%3B RNA-binding%3B Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA)%2C required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape%2C replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gen%3B the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide'%2C a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA%2C entering the A-site of stalled ribosomes%2C displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRN%3B the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation%2C which seems to be the essential function of trans- translation%3B Belongs to the SmpB family gene gene47 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00048 S101447_00049 S101447_00049 S101447_00049 48537 49214 - Cold shock protein ScoF Activator%3B Cytoplasm%3B DNA-binding%3B Stress response%3B Transcription%3B Transcription regulation%3B Contains 1 CSD (cold-shock) domain gene gene48 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00049 S101447_00050 S101447_00050 S101447_00050 49594 50655 + hypothetical protein gene gene49 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00050 S101447_00051 S101447_00051 S101447_00051 50870 51232 + hypothetical protein gene gene50 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00051 S101447_00052 S101447_00052 S101447_00052 51434 52183 + hypothetical protein gene gene51 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00052 S101447_00053 S101447_00053 S101447_00053 52201 53460 + uncharacterized protein To M. tuberculosis Rv2067c gene gene52 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00053 S101447_00054 S101447_00054 S101447_00054 53490 54005 + hypothetical protein gene gene53 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00054 S101447_00055 S101447_00055 fabD fabD 54146 55126 + [Acyl-carrier-protein] S-malonyltransferase Acyltransferase%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Transferase%3B Belongs to the FabD family%3B KEGG: tmb:Thimo_2381 (acyl-carrier-protein) S-malonyltransferase gene gene54 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00055 S101447_00056 S101447_00056 fabG fabG 55149 55892 + 3-oxoacyl-[acyl-carrier-protein] reductase Lipid metabolism%3B NAD%3B Oxidoreductase%3B Steroid metabolism%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: gdj:Gdia_3406 3-oxoacyl-(acyl-carrier protein) reductase gene gene55 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00056 S101447_00057 S101447_00057 S101447_00057 56196 56435 + Acyl carrier protein Cytoplasm%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Phosphopantetheine%3B Phosphoprotein%3B Carrier of the growing fatty acid chain in fatty acid biosynthesis%3B Contains 1 acyl carrier domain gene gene56 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00057 S101447_00058 S101447_00058 fabF fabF 56500 57810 + Beta-ketoacyl-[acyl-carrier-protein] synthase II Acyltransferase%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Transferase%3B Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP%3B Belongs to the beta-ketoacyl-ACP synthases family%3B KEGG: apt:APA01_11730 3-oxoacyl-(acyl-carrier-protein) synthase II gene gene57 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00058 S101447_00059 S101447_00059 S101447_00059 57800 58834 + UPF0755 protein Belongs to the UPF0755 family gene gene58 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00059 S101447_00060 S101447_00060 S101447_00060 58887 59735 - hypothetical protein gene gene59 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00060 S101447_00061 S101447_00061 impA impA 59827 60624 - Inositol-phosphate phosphatase Amino-acid biosynthesis%3B Histidine biosynthesis%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Catalyzes the dephosphorylation of histidinol-phosphate to histidinol%2C the direct precursor of histidine%3B Belongs to the inositol monophosphatase family%3B KEGG: apt:APA01_11700 myo-inositol-1(or 4)-monophosphatase gene gene60 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00061 S101447_00062 S101447_00062 lpxL lpxL 60748 61671 - Kdo(2)-lipid IV(A) lauroyltransferase KEGG: apt:APA01_11690 KDO2-lipid IV(A) lauroyltransferase gene gene61 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00062 S101447_00063 S101447_00063 lpxK lpxK 61668 62528 - Tetraacyldisaccharide 4'-kinase ATP-binding%3B Kinase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Nucleotide-binding%3B Transferase%3B Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1%2C4'-bis-phosphate (lipid IVA)%3B Belongs to the LpxK family%3B KEGG: paca:ID47_10190 tetraacyldisaccharide 4'-kinase gene gene62 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00063 S101447_00064 S101447_00064 kdtA kdtA 62657 64681 - Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase Glycosyltransferase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Mitochondrion%3B Transferase%3B Transit peptide%3B Involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A)%2C the tetraacyldisaccharide-1%2C4'- bisphosphate precursor of lipid A. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts%2C or may be involved in signal transduction or plant defense responses%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 30 subfamily%3B KEGG: apt:APA01_11670 3-deoxy-D-manno-octulosonic-acid transferase gene gene63 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00064 S101447_00065 S101447_00065 S101447_00065 64697 65185 - hypothetical protein gene gene64 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00065 S101447_00066 S101447_00066 cysI cysI 65172 66863 - Assimilatory sulfite reductase (NADPH) 4Fe-4S%3B Heme%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase%3B Thioether bond%3B Catalyzes the reduction of sulfite to sulfide%2C a step in the biosynthesis of sulfur-containing amino acids and cofactors%3B Belongs to the nitrite and sulfite reductase 4Fe-4S domain family%3B KEGG: apt:APA01_11650 sulfite reductase (NADPH) hemoprotein beta-component gene gene65 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00066 S101447_00067 S101447_00067 S101447_00067 66897 67238 - Assimilatory sulfite reductase (NADPH) KEGG: ppk:U875_09395 sulfite reductase (NADPH) hemoprotein beta-component gene gene66 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00067 S101447_00068 S101447_00068 S101447_00068 67430 69310 - Sulfate adenylyltransferase Cytoplasm%3B Elongation factor%3B GTP-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain%3B KEGG: apt:APA01_11630 bifunctional enzyme CysN/CysC gene gene67 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00068 S101447_00069 S101447_00069 cysD cysD 69339 70133 - Sulfate adenylyltransferase ATP-binding%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase%3B Belongs to the PAPS reductase family. CysD subfamily%3B KEGG: plu:plu0709 sulfate adenylyltransferase subunit 2 gene gene68 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00069 S101447_00070 S101447_00070 cysH cysH 70198 70962 - Phosphoadenylyl-sulfate reductase (thioredoxin) Cytoplasm%3B Oxidoreductase%3B Reduction of activated sulfate into sulfite%3B Belongs to the PAPS reductase family. CysH subfamily%3B KEGG: apt:APA01_11610 phosphoadenosine phosphosulfate reductase gene gene69 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00070 S101447_00071 S101447_00071 S101447_00071 71285 71560 - uncharacterized protein gene gene70 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00071 S101447_00072 S101447_00072 bioB bioB 71730 72740 + Biotin synthase 2Fe-2S%3B 4Fe-4S%3B Biotin biosynthesis%3B Iron%3B Iron-sulfur%3B Metal-binding%3B S-adenosyl-L-methionine%3B Transferase%3B Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism%3B Belongs to the radical SAM superfamily. Biotin synthase family%3B KEGG: apt:APA01_11590 biotin synthase gene gene71 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00072 S101447_00073 S101447_00073 S101447_00073 72744 73394 + 7-carboxy-7-deazaguanine synthase 4Fe-4S%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding%3B Queuosine biosynthesis%3B S-adenosyl-L-methionine%3B Catalyzes the conversion of 6-carboxy-5%2C6%2C7%2C8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG)%3B Belongs to the radical SAM superfamily. 7-carboxy-7- deazaguanine synthase family gene gene72 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00073 S101447_00074 S101447_00074 queC queC 73397 74137 + 7-cyano-7-deazaguanine synthase ATP-binding%3B Ligase%3B Metal-binding%3B Nucleotide-binding%3B Queuosine biosynthesis%3B Zinc%3B Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))%3B Belongs to the QueC family%3B KEGG: apt:APA01_11570 7-cyano-7-deazaguanine synthase gene gene73 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00074 S101447_00075 S101447_00075 queD queD 74130 74678 + 6-pyruvoyltetrahydropterin synthase KEGG: gdj:Gdia_3393 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase gene gene74 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00075 S101447_00076 S101447_00076 S101447_00076 74727 76226 - Malate dehydrogenase (quinone) FAD%3B Flavoprotein%3B Oxidoreductase%3B Tricarboxylic acid cycle%3B Belongs to the MQO family%3B KEGG: apt:APA01_11550 malate dehydrogenase (quinone) gene gene75 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00076 S101447_00077 S101447_00077 S101447_00077 76514 76948 + Peroxiredoxin OsmC Acetylation%3B Antioxidant%3B Cytoplasm%3B Oxidoreductase%3B Peroxidase%3B Preferentially metabolizes organic hydroperoxides over inorganic hydrogen peroxide%3B Belongs to the OsmC/Ohr family gene gene76 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00077 S101447_00078 S101447_00078 aroC aroC 76965 78035 - Chorismate synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B FAD%3B Flavoprotein%3B FMN%3B Lyase%3B NADP%3B Catalyzes the anti-1%2C4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate%2C which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system%3B Belongs to the chorismate synthase family%3B KEGG: apt:APA01_11530 chorismate synthase gene gene77 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00078 S101447_00079 S101447_00079 fabI fabI 78045 78884 - Enoyl-[acyl-carrier-protein] reductase (NADH) Cell inner membrane%3B Cell membrane%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B NAD%3B Oxidoreductase%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily%3B KEGG: apt:APA01_11520 enoyl-(acyl-carrier protein) reductase I gene gene78 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00079 S101447_00080 S101447_00080 pdxH pdxH 79073 79711 + Pyridoxal 5'-phosphate synthase Flavoprotein%3B FMN%3B Oxidoreductase%3B Pyridoxine biosynthesis%3B Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)%3B Belongs to the pyridoxamine 5'-phosphate oxidase family%3B KEGG: apt:APA01_11510 pyridoxamine 5'-phosphate oxidase gene gene79 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00080 S101447_00081 S101447_00081 S101447_00081 79766 80644 + hypothetical protein gene gene80 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00081 S101447_00082 S101447_00082 phnP phnP 80693 81487 - Phosphoribosyl 1%2C2-cyclic phosphate phosphodiesterase Acyltransferase%3B Cytoplasm%3B Transferase%3B Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate%3B In the C-terminal sectio%3B belongs to the LipB family%3B Contains 1 BPL/LPL catalytic domain%3B KEGG: apt:APA01_11490 phosphoribosyl 1%2C2-cyclic phosphate phosphodiesterase gene gene81 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00082 S101447_00083 S101447_00083 tatD tatD 81519 82328 - putative metal-dependent hydrolase Hydrolase%3B Metal-binding%3B Belongs to the TatD-type hydrolase family%3B KEGG: apt:APA01_11480 TatD DNase family protein%3B Endodeoxyribonucleases producing 5'-phosphomonoesters gene gene82 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00083 S101447_00084 S101447_00084 marS marS 82331 83869 - Methionine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B Zinc%3B Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation%3B Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily%3B KEGG: gox:GOX0016 methionyl-tRNA synthetase gene gene83 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00084 S101447_00085 S101447_00085 holB holB 83866 84828 - DNA-directed DNA polymerase DNA replication%3B DNA-directed DNA polymerase%3B Nucleotidyltransferase%3B Transferase%3B DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)%3B KEGG: apk:APA386B_2666 DNA polymerase III subunit delta' gene gene84 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00085 S101447_00086 S101447_00086 S101447_00086 84815 85447 - dTMP kinase ATP-binding%3B Kinase%3B Nucleotide biosynthesis%3B Nucleotide-binding%3B Transferase%3B Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis%3B Belongs to the thymidylate kinase family%3B KEGG: apt:APA01_11450 dTMP kinase gene gene85 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00086 S101447_00087 S101447_00087 dacC dacC 85463 86683 - Serine-type D-Ala-D-Ala carboxypeptidase Carboxypeptidase%3B Cell shape%3B Cell wall%3B Cell wall biogenesis/degradation%3B Hydrolase%3B Peptidoglycan synthesis%3B Protease%3B Secreted%3B Signal%3B Sporulation%3B Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Belongs to the peptidase S11 family%3B KEGG: apt:APA01_11440 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6) gene gene86 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00087 S101447_00088 S101447_00088 S101447_00088 86690 87556 - RlpA-like lipoprotein Cell membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Belongs to the RlpA family gene gene87 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00088 S101447_00089 S101447_00089 S101447_00089 87553 88548 - Membrane-bound lytic murein transglycosylase Cell outer membrane%3B Cell wall biogenesis/degradation%3B Lipoprotein%3B Lyase%3B Membrane%3B Palmitate%3B Signal. gene gene88 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00089 S101447_00090 S101447_00090 S101447_00090 88777 89343 + hypothetical protein gene gene89 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00090 S101447_00091 S101447_00091 S101447_00091 89340 90404 + hypothetical protein gene gene90 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00091 S101447_00092 S101447_00092 S101447_00092 90406 91932 - Cationic amino acid transporter Amino-acid transport%3B Glycoprotein%3B Membrane%3B Phosphoprotein%3B Polymorphism%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the transport of the cationic amino acids (arginine%2C lysine and ornithine). Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2. A. 3. 3) family gene gene91 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00092 S101447_00093 S101447_00093 bacA bacA 91949 92797 - Undecaprenyl-diphosphate phosphatase Antibiotic resistance%3B Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Hydrolase%3B Membrane%3B Peptidoglycan synthesis%3B Transmembrane%3B Transmembrane helix%3B Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin%3B Belongs to the UppP family%3B KEGG: apt:APA01_11380 undecaprenyl-diphosphatase gene gene92 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00093 S101447_00094 S101447_00094 S101447_00094 92872 93378 + hypothetical protein gene gene93 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00094 S101447_00095 S101447_00095 S101447_00095 93478 93552 + tRNA-Met tRNA gene94 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00095 S101447_00096 S101447_00096 S101447_00096 93734 94081 - hypothetical protein gene gene95 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00096 S101447_00097 S101447_00097 hemK hemK 94426 95304 - Peptide chain release factor N(5)-glutamine methyltransferase Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif%3B Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily%3B KEGG: apt:APA01_11340 release factor glutamine methyltransferase gene gene96 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00097 S101447_00098 S101447_00098 S101447_00098 95342 95806 + hypothetical protein gene gene97 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00098 S101447_00099 S101447_00099 S101447_00099 95803 96861 - Peptide chain release factor Cytoplasm%3B Methylation%3B Protein biosynthesis%3B Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA%3B Belongs to the prokaryotic/mitochondrial release factor family gene gene98 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00099 S101447_00100 S101447_00100 harS harS 96858 98129 - Histidine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: apt:APA01_11310 histidyl-tRNA synthetase gene gene99 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00100 S101447_00101 S101447_00101 gcpE gcpE 98233 99393 - (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin) 4Fe-4S%3B Iron%3B Iron-sulfur%3B Isoprene biosynthesis%3B Metal-binding%3B Oxidoreductase%3B Converts 2C-methyl-D-erythritol 2%2C4-cyclodiphosphate (ME-2%2C4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate%3B Belongs to the IspG family%3B KEGG: apt:APA01_11300 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase gene gene100 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00101 S101447_00102 S101447_00102 S101447_00102 99530 100804 - putative membrane protein YmfM Cell membrane%3B Coiled coil%3B Membrane%3B Transmembrane%3B Transmembrane helix. gene gene101 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00102 S101447_00103 S101447_00103 fabK fabK 100797 101882 - Enoyl-[acyl-carrier-protein] reductase (NADH) KEGG: apt:APA01_11280 enoyl-(acyl-carrier protein) reductase II gene gene102 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00103 S101447_00104 S101447_00104 lysC lysC 101872 103125 - Aspartate kinase Alternative initiation%3B Amino-acid biosynthesis%3B ATP-binding%3B Diaminopimelate biosynthesis%3B Kinase%3B Lysine biosynthesis%3B Nucleotide-binding%3B Repeat%3B Transferase%3B Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate%2C which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine%2C isoleucine and methionine%3B Belongs to the aspartokinase family%3B Contains 2 ACT domains%3B KEGG: apt:APA01_11270 aspartate kinase gene gene103 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00104 S101447_00105 S101447_00105 ubiG ubiG 103298 104038 + 2-polyprenyl-6-hydroxyphenol methylase Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Ubiquinone biosynthesis%3B O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway%3B Belongs to the methyltransferase superfamily. UbiG/COQ3 family%3B KEGG: apt:APA01_11260 2-polyprenyl-6-hydroxyphenyl methylase / 3-demethylubiquinone-9 3-methyltransferase gene gene104 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00105 S101447_00106 S101447_00106 S101447_00106 104091 105353 - 6-phosphogluconolactonase Carbohydrate metabolism%3B Glucose metabolism%3B Hydrolase%3B Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate%3B Belongs to the cycloisomerase 2 family%3B KEGG: taz:TREAZ_2399 6-phosphogluconolactonase gene gene105 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00106 S101447_00107 S101447_00107 S101447_00107 105384 105896 - hypothetical protein gene gene106 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00107 S101447_00108 S101447_00108 S101447_00108 105856 106068 - hypothetical protein gene gene107 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00108 S101447_00109 S101447_00109 S101447_00109 106028 106513 - hypothetical protein gene gene108 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00109 S101447_00110 S101447_00110 S101447_00110 106534 106800 - Glutaredoxin-3 Deoxyribonucleotide synthesis%3B Disulfide bond%3B Electron transport%3B Redox-active center%3B Transport%3B The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition%2C it is also involved in reducing some disulfides in a coupled system with glutathione reductase (By similarity)%3B Belongs to the glutaredoxin family%3B Contains 1 glutaredoxin domain gene gene109 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00110 S101447_00111 S101447_00111 S101447_00111 106850 107617 - hypothetical protein gene gene110 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00111 S101447_00112 S101447_00112 S101447_00112 107690 108565 + NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor Membrane%3B Methyltransferase%3B Mitochondrion%3B Mitochondrion inner membrane%3B Transferase%3B Transit peptide%3B Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I%2C MT-ND1) at early stages. May have methyltransferase activity (By similarity)%3B Belongs to the methyltransferase superfamily%3B KEGG: dosa:Os12t0203100-01 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 5%3B Methyltransferases gene gene111 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00112 S101447_00113 S101447_00113 moaA moaA 108578 109594 - Cyclic pyranopterin phosphate synthase 4Fe-4S%3B GTP-binding%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding%3B Molybdenum cofactor biosynthesis%3B Nucleotide-binding%3B S-adenosyl-L-methionine%3B Catalyzes%2C together with MoaC%2C the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z)%3B Belongs to the radical SAM superfamily. MoaA family%3B KEGG: apt:APA01_11190 cyclic pyranopterin phosphate synthase gene gene112 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00113 S101447_00114 S101447_00114 manB manB 109734 111143 - Phosphomannomutase Alginate biosynthesis%3B Isomerase%3B Lipopolysaccharide biosynthesis%3B Magnesium%3B Metal-binding%3B Multifunctional enzyme%3B Phosphoprotein%3B Virulence%3B Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization%2C the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production%2C an exoproduct correlated with pathogenicity. Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reaction%3B first from enzyme-phospho-Ser-108 to the substrate (generating a bisphosphorylated substrate intermediate and a dephosphorylated enzyme)%2C a 180 degree rotation of the intermediate (probably aided by movement of domain 4)%2C and subsequent transfer of phosphate back to the enzyme%3B Belongs to the phosphohexose mutase family%3B KEGG: gbe:GbCGDNIH1_0590 phosphomannomutase gene gene113 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00114 S101447_00115 S101447_00115 ugp2 ugp2 111143 112033 - UTP--glucose-1-phosphate uridylyltransferase Capsule biogenesis/degradation%3B Exopolysaccharide synthesis%3B Nucleotidyltransferase%3B Transferase%3B Belongs to the UDPGP type 2 family%3B KEGG: hni:W911_15405 UTP--glucose-1-phosphate uridylyltransferase gene gene114 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00115 S101447_00116 S101447_00116 S101447_00116 112372 112458 - tRNA-Leu tRNA gene115 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00116 S101447_00117 S101447_00117 lipB lipB 112531 113232 + Lipoyl(octanoyl) transferase Acyltransferase%3B Cytoplasm%3B Transferase%3B Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate%3B Belongs to the LipB family%3B Contains 1 BPL/LPL catalytic domain%3B KEGG: apt:APA01_11150 lipoyl(octanoyl) transferase gene gene116 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00117 S101447_00118 S101447_00118 S101447_00118 113213 113785 - hypothetical protein gene gene117 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00118 S101447_00119 S101447_00119 S101447_00119 113785 114123 - BolA-like protein Phosphoprotein%3B Secreted%3B Belongs to the BolA/IbaG family gene gene118 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00119 S101447_00120 S101447_00120 S101447_00120 114247 114795 + putative 19.0 kDa protein in cobS 5'region Contains 1 J domain gene gene119 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00120 S101447_00121 S101447_00121 cobS cobS 114884 115891 + Cobaltochelatase ATP-binding%3B Cobalamin biosynthesis%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Porphyrin biosynthesis%3B KEGG: apt:APA01_11110 cobaltochelatase CobS gene gene120 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00121 S101447_00122 S101447_00122 cobT cobT 115905 117821 + Cobaltochelatase ATP-binding%3B Cobalamin biosynthesis%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Porphyrin biosynthesis%3B Catalyzes cobalt insertion in the corrin ring. Contains 1 VWFA domain%3B KEGG: apt:APA01_11100 cobaltochelatase CobT gene gene121 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00122 S101447_00123 S101447_00123 S101447_00123 117853 119298 - Aromatic-L-amino-acid decarboxylase Decarboxylase%3B Lyase%3B Pyridoxal phosphate%3B Belongs to the group II decarboxylase family%3B KEGG: nwi:Nwi_1102 aromatic-L-amino-acid decarboxylase gene gene122 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00123 S101447_00124 S101447_00124 S101447_00124 119323 120288 - uncharacterized protein gene gene123 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00124 S101447_00125 S101447_00125 S101447_00125 120385 121305 + hypothetical protein gene gene124 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00125 S101447_00126 S101447_00126 S101447_00126 121356 124832 - Transcription-repair-coupling factor ATP-binding%3B Cytoplasm%3B DNA damage%3B DNA repair%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA%2C and recruitment of nucleotide excision repair machinery to the damaged site%3B In the N-terminal sectio%3B belongs to the UvrB family%3B In the C-terminal sectio%3B belongs to the helicase family. RecG subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: apt:APA01_11060 transcription-repair coupling factor (superfamily II helicase)%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene125 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00126 S101447_00127 S101447_00127 S101447_00127 124910 125239 - Succinate dehydrogenase assembly factor 2%2C mitochondrial Chaperone%3B Mitochondrion%3B Transit peptide%3B Plays an essential role in the assembly of succinate dehydrogenase (SDH)%2C an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain%2C and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer%3B Belongs to the SDHAF2 family gene gene126 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00127 S101447_00128 S101447_00128 recG recG 125309 127456 + DNA helicase ATP-binding%3B DNA damage%3B DNA recombination%3B DNA repair%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) (By similarity)%3B Belongs to the helicase family. RecG subfamily%3B Contains 1 helicase ATP-binding domain%3B KEGG: apt:APA01_11040 ATP-dependent DNA helicase RecG gene gene127 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00128 S101447_00129 S101447_00129 thiE thiE 127469 128074 - Thiamine phosphate synthase Magnesium%3B Metal-binding%3B Plasmid%3B Thiamine biosynthesis%3B Transferase%3B Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)%3B Belongs to the thiamine-phosphate synthase family%3B KEGG: apt:APA01_11030 thiamine-phosphate pyrophosphorylase gene gene128 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00129 S101447_00130 S101447_00130 thiG thiG 128071 128847 - Thiazole synthase Cytoplasm%3B Schiff base%3B Thiamine biosynthesis%3B Transferase%3B Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro%2C sulfur can be provided by H(2)S%3B Belongs to the ThiG family%3B KEGG: apt:APA01_11020 thiazole synthase gene gene129 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00130 S101447_00131 S101447_00131 S101447_00131 128852 129049 - hypothetical protein gene gene130 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00131 S101447_00132 S101447_00132 thiO thiO 129063 130034 - Glycine oxidase Oxidoreductase%3B Plasmid%3B Thiamine biosynthesis%3B KEGG: apt:APA01_11000 glycine oxidase gene gene131 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00132 S101447_00133 S101447_00133 S101447_00133 130136 130612 - hypothetical protein gene gene132 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00133 S101447_00134 S101447_00134 S101447_00134 130795 132075 + Phosphopyruvate hydratase Cytoplasm%3B Glycolysis%3B Lyase%3B Magnesium%3B Metal-binding%3B Secreted%3B Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis%3B Belongs to the enolase family%3B KEGG: rso:RSc1129 enolase gene gene133 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00134 S101447_00135 S101447_00135 S101447_00135 132246 132575 + hypothetical protein gene gene134 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00135 S101447_00136 S101447_00136 S101447_00136 132688 132855 - 50S ribosomal protein L33 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein L33P family gene gene135 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00136 S101447_00137 S101447_00137 moeA moeA 133000 134199 + Molybdopterin molybdotransferase Magnesium%3B Metal-binding%3B Molybdenum%3B Molybdenum cofactor biosynthesis%3B Transferase%3B Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP%3B Belongs to the MoeA family%3B KEGG: apt:APA01_10950 molybdopterin molybdotransferase gene gene136 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00137 S101447_00138 S101447_00138 lexA lexA 134286 134936 + Repressor LexA Autocatalytic cleavage%3B DNA damage%3B DNA repair%3B DNA replication%3B DNA-binding%3B Hydrolase%3B Repressor%3B SOS response%3B Transcription%3B Transcription regulation%3B Represses a number of genes involved in the response to DNA damage (SOS response)%2C including recA and lexA. In the presence of single-stranded DNA%2C RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA%2C leading to derepression of the SOS regulon and eventually DNA repair%3B Belongs to the peptidase S24 family%3B KEGG: apt:APA01_10940 repressor LexA gene gene137 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00138 S101447_00139 S101447_00139 bioD bioD 134991 136388 - Dethiobiotin synthase Biotin biosynthesis%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway%3B Belongs to the methyltransferase superfamily%3B KEGG: apt:APA01_10930 dethiobiotin synthetase gene gene138 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00139 S101447_00140 S101447_00140 bioH bioH 136385 137077 - Pimeloyl-[acyl-carrier protein] methyl ester esterase KEGG: apt:APA01_10920 pimeloyl-(acyl-carrier protein) methyl ester esterase gene gene139 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00140 S101447_00141 S101447_00141 bioF bioF 137077 138258 - 8-amino-7-oxononanoate synthase Biotin biosynthesis%3B Pyridoxal phosphate%3B Transferase%3B Catalyzes the decarboxylative condensation of pimeloyl- [acyl-carrier protein] and L-alanine to produce 8-amino-7- oxononanoate (AON)%2C [acyl-carrier protein]%2C and carbon dioxide%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily%3B KEGG: apt:APA01_10910 8-amino-7-oxononanoate synthase gene gene140 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00141 S101447_00142 S101447_00142 bioA bioA 138316 139608 + Adenosylmethionine--8-amino-7-oxononanoate transaminase 2Fe-2S%3B 4Fe-4S%3B Aminotransferase%3B Biotin biosynthesis%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Multifunctional enzyme%3B Pyridoxal phosphate%3B S-adenosyl-L-methionine%3B Transferase%3B Catalyzes two activities which are involved in the biotine biosynthesis: the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism%2C and the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7%2C8-diaminopelargonic acid (DAPA)%3B In the N-terminal sectio%3B belongs to the radical SAM superfamily. Biotin synthase family%3B In the C-terminal sectio%3B belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily%3B KEGG: apt:APA01_10900 adenosylmethionine---8-amino-7-oxononanoate aminotransferase gene gene141 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00142 S101447_00143 S101447_00143 moaE moaE 139611 140081 - Molybdopterin synthase Molybdenum cofactor biosynthesis%3B Transferase%3B Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity)%3B Belongs to the MoaE family%3B KEGG: apt:APA01_10890 molybdopterin synthase catalytic subunit gene gene142 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00143 S101447_00144 S101447_00144 S101447_00144 140087 140350 - hypothetical protein gene gene143 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00144 S101447_00145 S101447_00145 S101447_00145 140415 140942 - hypothetical protein gene gene144 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00145 S101447_00146 S101447_00146 pgsA pgsA 141128 141697 - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Cell membrane%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B This protein catalyzes the committed step to the synthesis of the acidic phospholipids%3B Belongs to the CDP-alcohol phosphatidyltransferase class-I family%3B KEGG: gox:GOX2274 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase gene gene145 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00146 S101447_00147 S101447_00147 S101447_00147 141800 143710 - UvrABC system protein Cytoplasm%3B DNA damage%3B DNA excision%3B DNA repair%3B Excision nuclease%3B SOS response%3B The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision%3B Belongs to the UvrC family%3B Contains 1 GIY-YIG domain%3B Contains 1 UVR domain gene gene146 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00147 S101447_00148 S101447_00148 dpeP dpeP 143971 145032 - Membrane dipeptidase Dipeptidase%3B Disulfide bond%3B Glycoprotein%3B Hydrolase%3B Membrane%3B Metal-binding%3B Metalloprotease%3B Protease%3B Transmembrane%3B Transmembrane helix%3B Zinc%3B Hydrolyzes a wide range of dipeptides%3B Belongs to the peptidase M19 family%3B KEGG: apt:APA01_10840 membrane dipeptidase gene gene147 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00148 S101447_00149 S101447_00149 xthA xthA 145150 145950 + Exodeoxyribonuclease III DNA damage%3B DNA repair%3B Exonuclease%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nuclease%3B Major apurinic-apyrimidinic endonuclease of E. coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease%2C 3'-phosphomonoesterase%2C 3'-repair diesterase and ribonuclease H activities. Belongs to the DNA repair enzymes AP/ExoA family%3B KEGG: eca:ECA2335 exodeoxyribonuclease III gene gene148 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00149 S101447_00150 S101447_00150 S101447_00150 146007 150236 - hypothetical protein gene gene149 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00150 S101447_00151 S101447_00151 S101447_00151 150236 152164 - hypothetical protein gene gene150 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00151 S101447_00152 S101447_00152 plsC plsC 152417 153508 + 1-acylglycerol-3-phosphate O-acyltransferase Acyltransferase%3B Cell inner membrane%3B Cell membrane%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Transferase%3B Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family%3B KEGG: apt:APA01_10790 1-acyl-sn-glycerol-3-phosphate acyltransferase gene gene151 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00152 S101447_00153 S101447_00153 miaB miaB 153713 155098 + tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase 4Fe-4S%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B S-adenosyl-L-methionine%3B Transferase%3B tRNA processing%3B Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A)%2C leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine%3B Belongs to the methylthiotransferase family. MiaB subfamily%3B Contains 1 MTTase N-terminal domain%3B Contains 1 TRAM domain%3B KEGG: apt:APA01_10780 tRNA-2-methylthio-N6-dimethylallyladenosine synthase gene gene152 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00153 S101447_00154 S101447_00154 S101447_00154 155095 156180 + PhoH-like protein ATP-binding%3B Cytoplasm%3B Nucleotide-binding%3B Belongs to the PhoH family gene gene153 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00154 S101447_00155 S101447_00155 S101447_00155 156164 156703 + Endoribonuclease YbeY Cytoplasm%3B Endonuclease%3B Hydrolase%3B Metal-binding%3B Nuclease%3B Ribosome biogenesis%3B rRNA processing%3B Zinc%3B Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA%3B Belongs to the endoribonuclease YbeY family gene gene154 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00155 S101447_00156 S101447_00156 S101447_00156 156700 157644 + DUF21 domain-containing protein CBS domain%3B Chloroplast%3B Membrane%3B Plastid%3B Repeat%3B Transit peptide%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain gene gene155 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00156 S101447_00157 S101447_00157 S101447_00157 157717 158337 + hypothetical protein gene gene156 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00157 S101447_00158 S101447_00158 S101447_00158 158377 162924 + Chromosome partition protein Smc ATP-binding%3B Coiled coil%3B Cytoplasm%3B DNA-binding%3B Nucleotide-binding%3B Required for chromosome condensation and partitioning%3B Belongs to the SMC family gene gene157 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00158 S101447_00159 S101447_00159 glpQ glpQ 162911 163669 + Glycerophosphodiester phosphodiesterase KEGG: goh:B932_1576 glycerophosphoryl diester phosphodiesterase gene gene158 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00159 S101447_00160 S101447_00160 aarC aarC 163755 165272 - Succinyl-CoA:acetate CoA-transferase Transferase%3B Utilizes succinyl-CoA to convert toxic acetate to acetyl-CoA and succinate. Required for growth on acetic acid and for resistance to high levels of acetic acid. Has also low activity with acetoacetate as substrate%3B Belongs to the acetyl-CoA hydrolase/transferase family%3B KEGG: apt:APA01_10710 succinyl-CoA:acetate CoA-transferase gene gene159 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00160 S101447_00161 S101447_00161 S101447_00161 165390 165533 - hypothetical protein gene gene160 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00161 S101447_00162 S101447_00162 S101447_00162 165580 166311 + Protein-serine/threonine phosphatase GTP-binding%3B Hydrolase%3B Nickel%3B Nucleotide-binding%3B Asymmetrically hydrolyzes Ap4p to yield AMP and ATP%3B Belongs to the PrpE family%3B KEGG: apt:APA01_10700 protein phosphatase gene gene161 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00162 S101447_00163 S101447_00163 S101447_00163 166378 166707 + Chorismate mutase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Cytoplasm%3B Isomerase%3B Multifunctional enzyme%3B NAD%3B Oxidoreductase%3B Tyrosine biosynthesis%3B Contains 1 chorismate mutase domain%3B Contains 1 prephenate/arogenate dehydrogenase domain%3B KEGG: apt:APA01_10690 chorismate mutase gene gene162 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00163 S101447_00164 S101447_00164 S101447_00164 166717 167241 + hypothetical protein gene gene163 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00164 S101447_00165 S101447_00165 gltA gltA 167394 168704 + Citrate (Si)-synthase Allosteric enzyme%3B Transferase%3B Tricarboxylic acid cycle%3B Belongs to the citrate synthase family%3B KEGG: apt:APA01_10670 citrate synthase gene gene164 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00165 S101447_00166 S101447_00166 S101447_00166 168868 169107 - hypothetical protein gene gene165 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00166 S101447_00167 S101447_00167 pyrE pyrE 169354 170109 + Orotate phosphoribosyltransferase Glycosyltransferase%3B Magnesium%3B Pyrimidine biosynthesis%3B Transferase%3B Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate%2C leading to the formation of orotidine monophosphate (OMP)%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily%3B KEGG: apt:APA01_10650 orotate phosphoribosyltransferase gene gene166 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00167 S101447_00168 S101447_00168 murI murI 170114 170962 + Glutamate racemase Cell shape%3B Cell wall biogenesis/degradation%3B Isomerase%3B Peptidoglycan synthesis%3B Provides the (R)-glutamate required for cell wall biosynthesis%3B Belongs to the aspartate/glutamate racemases family%3B KEGG: apt:APA01_10640 glutamate racemase gene gene167 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00168 S101447_00169 S101447_00169 ispB ispB 170999 172003 - All-trans-octaprenyl-diphosphate synthase Magnesium%3B Metal-binding%3B Transferase%3B Ubiquinone biosynthesis%3B catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with the allylic substrate to give solanesyl diphosphate. Could be important to determine the side chain length of ubiquinone%3B Belongs to the FPP/GGPP synthase family%3B KEGG: apt:APA01_10630 octaprenyl-diphosphate synthase gene gene168 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00169 S101447_00170 S101447_00170 yfiC yfiC 172187 172942 + tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase KEGG: apb:SAR116_2272 tRNA1Val (adenine37-N6)-methyltransferase gene gene169 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00170 S101447_00171 S101447_00171 nrdB nrdB 172948 173967 - Ribonucleoside-diphosphate reductase DNA replication%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)%3B Belongs to the ribonucleoside diphosphate reductase small chain family%3B KEGG: apt:APA01_10610 ribonucleoside-diphosphate reductase beta chain gene gene170 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00171 S101447_00172 S101447_00172 nrdA nrdA 174041 175972 - Ribonucleoside-diphosphate reductase Autocatalytic cleavage%3B Disulfide bond%3B DNA replication%3B Oxidoreductase%3B Protein splicing%3B Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)%3B Belongs to the ribonucleoside diphosphate reductase large chain family%3B Contains 1 DOD-type homing endonuclease domain%3B KEGG: apt:APA01_10600 ribonucleoside-diphosphate reductase alpha chain gene gene171 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00172 S101447_00173 S101447_00173 S101447_00173 176175 177152 - Glucose-6-phosphate 3-dehydrogenase Antibiotic biosynthesis%3B NAD%3B Oxidoreductase%3B Involved in the biosynthesis of kanosamine (3-amino-3- deoxy-D-glucose)%2C which is known to have antibiotic and antifungal properties%2C and to be a precursor of the antibiotic neotrehalosadiamine (3%2C3'-diamino-3%2C3'-dideoxy-alpha%2Cbeta- trehalose (NTD)). Catalyzes the oxidation of glucose 6-phosphate to 3-oxo-D-glucose 6-phosphate. It can only use NAD%3B Belongs to the Gfo/Idh/MocA family gene gene172 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00173 S101447_00174 S101447_00174 S101447_00174 177393 178952 + Protein translocase subunit SecD Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Translocation%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA%3B Belongs to the SecD/SecF family. SecD subfamily gene gene173 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00174 S101447_00175 S101447_00175 S101447_00175 178965 179915 + Protein translocase subunit SecF Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Translocation%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA%3B Belongs to the SecD/SecF family. SecF subfamily gene gene174 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00175 S101447_00176 S101447_00176 S101447_00176 179989 180393 - hypothetical protein gene gene175 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00176 S101447_00177 S101447_00177 S101447_00177 180478 180957 - Large-conductance mechanosensitive channel Cell inner membrane%3B Cell membrane%3B Ion channel%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell%3B Belongs to the MscL family gene gene176 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00177 S101447_00178 S101447_00178 S101447_00178 181246 181476 + 50S ribosomal protein L31 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Binds the 23S rRNA%3B Belongs to the ribosomal protein L31P family. Type A subfamily gene gene177 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00178 S101447_00179 S101447_00179 S101447_00179 181567 181662 + hypothetical protein gene gene178 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00179 S101447_00180 S101447_00180 S101447_00180 181659 182165 + Small heat shock protein HspA Stress response%3B Belongs to the small heat shock protein (HSP20) family gene gene179 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00180 S101447_00181 S101447_00181 S101447_00181 182409 183002 + hypothetical protein gene gene180 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00181 S101447_00182 S101447_00182 S101447_00182 183070 183234 - hypothetical protein gene gene181 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00182 S101447_00183 S101447_00183 S101447_00183 183474 183680 + hypothetical protein gene gene182 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00183 S101447_00184 S101447_00184 purE purE 183725 184273 + 5-(carboxyamino)imidazole ribonucleotide mutase ATP-binding%3B Decarboxylase%3B Lyase%3B Nucleotide-binding%3B Purine biosynthesis%3B In the C-terminal sectio%3B belongs to the AIR carboxylase family. Class I subfamily%3B Contains 1 ATP-grasp domain%3B KEGG: apt:APA01_10490 5-(carboxyamino)imidazole ribonucleotide mutase gene gene183 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00184 S101447_00185 S101447_00185 purK purK 184270 185451 + 5-(carboxyamino)imidazole ribonucleotide synthase ATP-binding%3B Ligase%3B Nucleotide-binding%3B Purine biosynthesis%3B Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)%3B Belongs to the PurK/PurT family%3B Contains 1 ATP-grasp domain%3B KEGG: apt:APA01_10480 5-(carboxyamino)imidazole ribonucleotide synthase gene gene184 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00185 S101447_00186 S101447_00186 S101447_00186 185474 186238 - UPF0758 protein Belongs to the UPF0758 family%3B overlaps another CDS with the same product name gene gene185 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00186 S101447_00187 S101447_00187 S101447_00187 186235 187059 - UPF0758 protein Belongs to the UPF0758 family%3B overlaps another CDS with the same product name gene gene186 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00187 S101447_00188 S101447_00188 uvrD uvrD 187105 189336 + DNA helicase ATP-binding%3B DNA replication%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replicatio%3B it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction%3B Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B Contains 1 uvrD-like helicase C-terminal domain%3B KEGG: apt:APA01_10450 DNA helicase II / ATP-dependent DNA helicase PcrA gene gene187 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00188 S101447_00189 S101447_00189 prmA prmA 189336 190256 + Ribosomal protein L11 methyltransferase Cytoplasm%3B Methyltransferase%3B Transferase%3B Methylates ribosomal protein L11%3B Belongs to the methyltransferase superfamily. PrmA family%3B KEGG: apt:APA01_10440 ribosomal protein L11 methyltransferase%3B Methyltransferases gene gene188 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00189 S101447_00190 S101447_00190 pepP pepP 190298 192079 + Xaa-Pro aminopeptidase Aminopeptidase%3B Hydrolase%3B Manganese%3B Metal-binding%3B Metalloprotease%3B Protease%3B Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides%3B Belongs to the peptidase M24B family%3B KEGG: apt:APA01_10430 Xaa-Pro aminopeptidase gene gene189 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00190 S101447_00191 S101447_00191 idh3 idh3 192177 193208 + Isocitrate dehydrogenase (NAD(+)) Magnesium%3B Manganese%3B Metal-binding%3B Mitochondrion%3B NAD%3B Oxidoreductase%3B Transit peptide%3B Tricarboxylic acid cycle%3B Performs an essential role in the oxidative function of the citric acid cycle%3B Belongs to the isocitrate and isopropylmalate dehydrogenases family%3B KEGG: apt:APA01_10420 isocitrate dehydrogenase (NAD+) gene gene190 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00191 S101447_00192 S101447_00192 S101447_00192 193308 194045 + hypothetical protein gene gene191 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00192 S101447_00193 S101447_00193 S101447_00193 194064 195611 - Peptide chain release factor Cytoplasm%3B GTP-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP%2C but not by GMP%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene192 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00193 S101447_00194 S101447_00194 S101447_00194 195711 196328 - 30S ribosomal protein S4 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit%3B With S5 and S12 plays an important role in translational accuracy%3B Belongs to the ribosomal protein S4P family%3B Contains 1 S4 RNA-binding domain gene gene193 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00194 S101447_00195 S101447_00195 S101447_00195 196601 197152 + hypothetical protein gene gene194 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00195 S101447_00196 S101447_00196 S101447_00196 197233 199833 - Na(+)/H(+) antiporter ApNhaP Antiport%3B Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Sodium%3B Sodium transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Shows also high Ca(2+)/H(+) antiporter activity at alkaline pH. Does not catalyze exchange between Li(+) and H(+)%3B Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2. A. 36) family gene gene195 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00196 S101447_00197 S101447_00197 S101447_00197 200104 200340 + hypothetical protein gene gene196 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00197 S101447_00198 S101447_00198 S101447_00198 200463 202172 + hypothetical protein gene gene197 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00198 S101447_00199 S101447_00199 S101447_00199 202271 203317 - Phosphate-binding protein PstS Periplasm%3B Phosphate transport%3B Signal%3B Transport%3B Part of the ABC transporter complex PstSACB involved in phosphate import%3B Belongs to the PstS family gene gene198 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00199 S101447_00200 S101447_00200 pheT pheT 203338 205797 - Phenylalanine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B RNA-binding%3B tRNA-binding%3B Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily%3B Contains 1 B5 domain%3B Contains 1 FDX-ACB domain%3B Contains 1 tRNA-binding domain%3B KEGG: tmb:Thimo_2823 phenylalanyl-tRNA synthetase beta chain gene gene199 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00200 S101447_00201 S101447_00201 pheS pheS 205801 206871 - Phenylalanine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily%3B KEGG: gox:GOX0262 phenylalanyl-tRNA synthetase alpha chain gene gene200 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00201 S101447_00202 S101447_00202 S101447_00202 207036 207395 - 50S ribosomal protein L20%2C chloroplastic Chloroplast%3B Plastid%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit%3B Belongs to the ribosomal protein L20P family gene gene201 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00202 S101447_00203 S101447_00203 S101447_00203 207410 207610 - 50S ribosomal protein L35 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein L35P family gene gene202 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00203 S101447_00204 S101447_00204 mtlK mtlK 207832 209304 + Mannitol 2-dehydrogenase NAD%3B Oxidoreductase%3B Belongs to the mannitol dehydrogenase family%3B KEGG: apt:APA01_10290 mannitol 2-dehydrogenase gene gene203 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00204 S101447_00205 S101447_00205 nicB nicB 209704 211032 + Nicotinate dehydrogenase (cytochrome) Aromatic hydrocarbons catabolism%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Molybdenum%3B Oxidoreductase%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation%2C the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA)%3B Contains 3 cytochrome c domains%3B KEGG: pfq:QQ39_15000 nicotinate dehydrogenase subunit B gene gene204 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00205 S101447_00206 S101447_00206 S101447_00206 211053 211529 + Isoquinoline 1-oxidoreductase 2Fe-2S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase%3B Specific towards N-containing N-heterocyclic substrates%2C including isoquinoline%2C isoquinolin-5-ol%2C phthalazine and quinazoline. Contains 1 2Fe-2S ferredoxin-type domain%3B KEGG: apt:APA01_10270 isoquinoline 1-oxidoreductase%2C alpha subunit%3B overlaps another CDS with the same product name gene gene205 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00206 S101447_00207 S101447_00207 S101447_00207 211522 213849 + Isoquinoline 1-oxidoreductase Cell inner membrane%3B Cell membrane%3B Membrane%3B Oxidoreductase%3B PQQ%3B Signal%3B KEGG: gau:GAU_3648 isoquinoline 1-oxidoreductase%2C beta subunit%3B overlaps another CDS with the same product name gene gene206 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00207 S101447_00208 S101447_00208 S101447_00208 213976 214419 - Cysteine desulfuration protein SufE Cytoplasm%3B Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS%2C by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS%2C an intermediate product of cysteine desulfuration process%3B Belongs to the SufE family gene gene207 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00208 S101447_00209 S101447_00209 S101447_00209 214419 215732 - ATP-dependent protease ATPase subunit HslU ATP-binding%3B Chaperone%3B Cytoplasm%3B Nucleotide-binding%3B Stress response%3B ATPase subunit of a proteasome-like degradation comple%3B this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis%3B Belongs to the ClpX chaperone family. HslU subfamily gene gene208 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00209 S101447_00210 S101447_00210 hslV hslV 215732 216331 - HslU--HslV peptidase Allosteric enzyme%3B Cytoplasm%3B Hydrolase%3B Metal-binding%3B Protease%3B Sodium%3B Threonine protease%3B Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery%3B Belongs to the peptidase T1B family. HslV subfamily%3B KEGG: apt:APA01_10230 ATP-dependent HslUV protease%2C peptidase subunit HslV gene gene209 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00210 S101447_00211 S101447_00211 S101447_00211 216378 218378 - Limited host range VirA protein ATP-binding%3B Cell membrane%3B Crown gall tumor%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Plasmid%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain gene gene210 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00211 S101447_00212 S101447_00212 S101447_00212 218362 220242 - Histidine kinase Cell cycle%3B Cytoplasm%3B Differentiation%3B GTP-binding%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Phosphoprotein%3B Repeat%3B Transducer%3B Transferase%3B Two-component regulatory system%3B Response regulator that is part of a signal transduction pathway controlling cell differentiation in the swarmer-to-stalked cell transition. Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP)%2C which acts as a secondary messenger. Contains 1 GGDEF domain%3B Contains 2 response regulatory domains%3B KEGG: apt:APA01_10210 two-component system%2C NtrC family%2C sensor kinase gene gene211 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00212 S101447_00213 S101447_00213 S101447_00213 220448 220843 + hypothetical protein gene gene212 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00213 S101447_00214 S101447_00214 S101447_00214 220897 221946 - Circumsporozoite protein Malaria%3B Repeat%3B Signal%3B Sporozoite%3B The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host). Belongs to the plasmodium circumsporozoite protein family%3B Contains 1 TSP type-1 domain gene gene213 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00214 S101447_00215 S101447_00215 S101447_00215 222116 222898 + Lipoprotein-releasing system ATP-binding protein LolD ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner%3B Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3. A. 1. 125) family%3B Contains 1 ABC transporter domain gene gene214 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00215 S101447_00216 S101447_00216 S101447_00216 222895 223839 + hypothetical protein gene gene215 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00216 S101447_00217 S101447_00217 S101447_00217 223818 224468 + hypothetical protein gene gene216 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00217 S101447_00218 S101447_00218 frmB frmB 224474 225340 - S-formylglutathione hydrolase Acetylation%3B Hydrolase%3B Serine esterase%3B Serine hydrolase involved in the detoxification of formaldehyde%3B Belongs to the esterase D family%3B KEGG: apt:APA01_10150 S-formylglutathione hydrolase gene gene217 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00218 S101447_00219 S101447_00219 S101447_00219 225485 226360 + UPF0187 protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0187 family gene gene218 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00219 S101447_00220 S101447_00220 S101447_00220 226471 227016 + RNA polymerase-binding transcription factor CarD Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for the stringent response to starvation%2C oxidative and genotoxic stresses as well as control of rRNA under normal growth conditions%3B Belongs to the CarD family gene gene219 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00220 S101447_00221 S101447_00221 S101447_00221 227155 228759 + Protein O-GlcNAc transferase Repeat%3B TPR repeat%3B In the C-terminal sectio%3B belongs to the protein sulfotransferase family%3B Contains 8 TPR repeats%3B KEGG: pif:PITG_17928 protein O-GlcNAc transferase gene gene220 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00221 S101447_00222 S101447_00222 S101447_00222 228846 230132 - hypothetical protein gene gene221 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00222 S101447_00223 S101447_00223 rsmI rsmI 230222 231190 + 16S rRNA (cytidine(1402)-2'-O)-methyltransferase Cytoplasm%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA%3B Belongs to the methyltransferase superfamily. RsmI family%3B KEGG: apt:APA01_10110 16S rRNA (cytidine1402-2'-O)-methyltransferase gene gene222 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00223 S101447_00224 S101447_00224 S101447_00224 231194 232408 - uncharacterized protein gene gene223 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00224 S101447_00225 S101447_00225 S101447_00225 232413 233081 - Glutathione transferase KEGG: eru:Erum2530 glutathione S-transferase gene gene224 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00225 S101447_00226 S101447_00226 S101447_00226 233266 233964 + putative septum site-determining protein MinC Cell cycle%3B Cell division%3B Septation%3B Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization%3B Belongs to the MinC family gene gene225 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00226 S101447_00227 S101447_00227 S101447_00227 234103 234918 + Septum site-determining protein MinD ATP-binding%3B Cell cycle%3B Cell division%3B Cell membrane%3B Membrane%3B Nucleotide-binding%3B Septation%3B ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings (By similarity)%3B Belongs to the ParA family. MinD subfamily gene gene226 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00227 S101447_00228 S101447_00228 S101447_00228 234915 235241 + Cell division topological specificity factor Cell cycle%3B Cell division%3B Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell%3B Belongs to the MinE family gene gene227 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00228 S101447_00229 S101447_00229 S101447_00229 235338 236057 - HTH-type transcriptional regulator McbR DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Important for biofilm formation. Represses expression of McbA by binding to its promoter region%2C which prevents colanic acid overproduction and mucoidy%3B Contains 1 HTH gntR-type DNA-binding domain gene gene228 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00229 S101447_00230 S101447_00230 S101447_00230 236057 237907 - Transport/processing ATP-binding protein ComA ATP-binding%3B Cell membrane%3B Competence%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Protease%3B Thiol protease%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Required for induction of competence. Seems to transport the competence-stimulating peptide (CSP). Belongs to the ABC transporter superfamily. Competence factor exporter (TC 3. A. 1. 112. 1) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B Contains 1 peptidase C39 domain gene gene229 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00230 S101447_00231 S101447_00231 S101447_00231 238495 240156 + hypothetical protein gene gene230 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00231 S101447_00232 S101447_00232 S101447_00232 240268 241473 + Lipopolysaccharide export system permease protein LptF Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane%3B Belongs to the LptF/LptG family gene gene231 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00232 S101447_00233 S101447_00233 S101447_00233 241490 242602 + hypothetical protein gene gene232 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00233 S101447_00234 S101447_00234 S101447_00234 242603 244936 + hypothetical protein gene gene233 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00234 S101447_00235 S101447_00235 surA surA 245018 246382 + Peptidylprolyl isomerase KEGG: apt:APA01_09980 peptidyl-prolyl cis-trans isomerase SurA gene gene234 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00235 S101447_00236 S101447_00236 ksgA ksgA 246627 247217 + 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase Cytoplasm%3B Methyltransferase%3B RNA-binding%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily%3B KEGG: apt:APA01_09970 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase gene gene235 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00236 S101447_00237 S101447_00237 S101447_00237 247224 248435 - Cyclopropane-fatty-acyl-phospholipid synthase Lipid biosynthesis%3B Lipid metabolism%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Belongs to the CFA/CMAS family%3B KEGG: apt:APA01_09960 cyclopropane-fatty-acyl-phospholipid synthase gene gene236 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00237 S101447_00238 S101447_00238 S101447_00238 248536 249141 - 50S ribosomal protein L9 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Binds to the 23S rRNA%3B Belongs to the ribosomal protein L9P family gene gene237 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00238 S101447_00239 S101447_00239 S101447_00239 249153 249428 - 30S ribosomal protein S18 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA%2C where it helps stabilize the platform of the 30S subunit%3B Belongs to the ribosomal protein S18P family gene gene238 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00239 S101447_00240 S101447_00240 S101447_00240 249435 249899 - 30S ribosomal protein S6 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Binds together with S18 to 16S ribosomal RNA%3B Belongs to the ribosomal protein S6P family gene gene239 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00240 S101447_00241 S101447_00241 S101447_00241 250066 250527 - Thiosulfate sulfurtransferase KEGG: agr:AGROH133_05485 thiosulfate/3-mercaptopyruvate sulfurtransferase gene gene240 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00241 S101447_00242 S101447_00242 S101447_00242 250637 252622 - RNA polymerase sigma factor RpoD Cytoplasm%3B DNA-binding%3B Fruiting body%3B Sigma factor%3B Sporulation%3B Transcription%3B Transcription regulation%3B Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth (By similarity). Also required for extracellular A-signal production. The A-signal is the first in a series of extracellular signals that are required for myxspore differentiation in M. xanthus. It is thought to act as a cell- density signal during early development to ensure there are enough cells present to complete fruiting-body morphogenesis. A variant at residue 598 prevents A-signal production in an unknown fashion%3B Belongs to the sigma-70 factor family. RpoD/SigA subfamily gene gene241 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00242 S101447_00243 S101447_00243 dnaG dnaG 252768 254609 - DNA primase DNA replication%3B DNA-binding%3B DNA-directed RNA polymerase%3B Magnesium%3B Metal-binding%3B Nucleotidyltransferase%3B Primosome%3B Transcription%3B Transferase%3B Zinc%3B Zinc-finger%3B RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication%3B Belongs to the DnaG primase family%3B Contains 1 Toprim domain%3B KEGG: apt:APA01_09900 DNA primase%3B Nucleotidyltransferases gene gene242 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00243 S101447_00244 S101447_00244 S101447_00244 254707 255162 - hypothetical protein gene gene243 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00244 S101447_00245 S101447_00245 carA carA 255397 256797 + Carbamoyl-phosphate synthase (glutamine-hydrolyzing) Amino-acid biosynthesis%3B Arginine biosynthesis%3B ATP-binding%3B Chloroplast%3B Glutamine amidotransferase%3B Ligase%3B Nucleotide-binding%3B Plastid%3B Pyrimidine biosynthesis%3B Belongs to the CarA family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: gxl:H845_2173 carbamoyl-phosphate synthase small subunit gene gene244 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00245 S101447_00246 S101447_00246 carB carB 256814 260068 + Carbamoyl-phosphate synthase (glutamine-hydrolyzing) Amino-acid biosynthesis%3B Arginine biosynthesis%3B ATP-binding%3B Ligase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nucleotide-binding%3B Pyrimidine biosynthesis%3B Belongs to the CarB family%3B Contains 1 ATP-grasp domain%3B KEGG: eco:b0033 carbamoyl-phosphate synthase large subunit gene gene245 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00246 S101447_00247 S101447_00247 S101447_00247 260235 260693 + Transcription elongation factor GreA DNA-binding%3B Transcription%3B Transcription regulation%3B Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through%2C resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides%3B Belongs to the GreA/GreB family gene gene246 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00247 S101447_00248 S101447_00248 ilvA ilvA 260695 261891 + Threonine ammonia-lyase Allosteric enzyme%3B Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Isoleucine biosynthesis%3B Lyase%3B Pyridoxal phosphate%3B Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate)%2C which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell%2C the second step is accelerated by RidA (By similarity)%3B Belongs to the serine/threonine dehydratase family%3B Contains 1 ACT-like domain%3B KEGG: cbw:RR42_m2239 threonine dehydratase gene gene247 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00248 S101447_00249 S101447_00249 gpmI gpmI 262051 263589 + Phosphoglycerate mutase (2%2C3-diphosphoglycerate-independent) Glycolysis%3B Isomerase%3B Manganese%3B Metal-binding%3B Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate%3B Belongs to the BPG-independent phosphoglycerate mutase family%3B KEGG: apt:APA01_09840 2%2C3-bisphosphoglycerate-independent phosphoglycerate mutase gene gene248 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00249 S101447_00250 S101447_00250 S101447_00250 263590 265056 + hypothetical protein gene gene249 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00250 S101447_00251 S101447_00251 ctpA ctpA 265235 266680 + C-terminal processing peptidase Hydrolase%3B Protease%3B Secreted%3B Serine protease%3B Signal%3B Involved in protection of the bacterium from thermal and osmotic stresses%3B Belongs to the peptidase S41A family%3B Contains 1 PDZ (DHR) domain%3B KEGG: apt:APA01_09820 carboxyl-terminal processing protease gene gene250 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00251 S101447_00252 S101447_00252 S101447_00252 266701 267792 + hypothetical protein gene gene251 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00252 S101447_00253 S101447_00253 nudH nudH 267789 268301 + RNA pyrophosphohydrolase Hydrolase%3B Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA%2C leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage%3B Belongs to the Nudix hydrolase family. RppH subfamily%3B Contains 1 nudix hydrolase domain%3B KEGG: apt:APA01_09800 putative (di)nucleoside polyphosphate hydrolase%3B In phosphorus-containing anhydrides gene gene252 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00253 S101447_00254 S101447_00254 S101447_00254 268384 269961 - Multidrug export protein Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the tripartite efflux system EmrAB-TolC%2C which confers resistance to antibiotics%3B Belongs to the major facilitator superfamily. EmrB family gene gene253 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00254 S101447_00255 S101447_00255 S101447_00255 269958 271130 - Multidrug export protein EmrA Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Coiled coil%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the tripartite efflux system EmrAB-TolC%2C which confers resistance to antibiotics such as CCCP%2C FCCP%2C 2%2C4- dinitrophenol and nalidixic acid. EmrA is a drug-binding protein that provides a physical link between EmrB and TolC%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene254 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00255 S101447_00256 S101447_00256 msbA msbA 271336 273129 - Lipid A export ATP-binding/permease protein MsbA ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Lipid transport%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation%3B Belongs to the ABC transporter superfamily. Lipid exporter (TC 3. A. 1. 106) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B KEGG: apt:APA01_09770 ATP-binding cassette%2C subfamily B%2C bacterial MsbA%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene255 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00256 S101447_00257 S101447_00257 pcnB pcnB 273187 274380 - Polynucleotide adenylyltransferase Acetylation%3B Alternative splicing%3B ATP-binding%3B Disease mutation%3B Disulfide bond%3B Magnesium%3B Mitochondrion%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Phosphoprotein%3B Polymorphism%3B RNA-binding%3B Transferase%3B Transit peptide%3B tRNA processing%3B Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules%2C using CTP and ATP as substrates. Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro)%3B Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family%3B KEGG: apt:APA01_09760 poly(A) polymerase gene gene256 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00257 S101447_00258 S101447_00258 S101447_00258 274377 274982 - hypothetical protein gene gene257 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00258 S101447_00259 S101447_00259 S101447_00259 275083 276102 + uncharacterized protein ATP-binding%3B Nucleotide-binding%3B Belongs to the MoxR family%3B KEGG: apt:APA01_09740 MoxR-like ATPase%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene258 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00259 S101447_00260 S101447_00260 S101447_00260 276108 277091 + hypothetical protein gene gene259 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00260 S101447_00261 S101447_00261 S101447_00261 277088 279874 + hypothetical protein gene gene260 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00261 S101447_00262 S101447_00262 S101447_00262 279871 282015 + hypothetical protein gene gene261 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00262 S101447_00263 S101447_00263 S101447_00263 282111 282704 + hypothetical protein gene gene262 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00263 S101447_00264 S101447_00264 ccrM ccrM 282765 283868 - Site-specific DNA-methyltransferase (adenine-specific) DNA replication%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. CcrM-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology. Essential for viability (By similarity)%3B Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: apt:APA01_09690 modification methylase gene gene263 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00264 S101447_00265 S101447_00265 rnhB rnhB 283865 284497 - Ribonuclease H Cytoplasm%3B Endonuclease%3B Hydrolase%3B Manganese%3B Metal-binding%3B Nuclease%3B Endonuclease that specifically degrades the RNA of RNA- DNA hybrids%3B Belongs to the RNase HII family%3B KEGG: apt:APA01_09680 ribonuclease HII gene gene264 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00265 S101447_00266 S101447_00266 S101447_00266 284623 284928 - hypothetical protein gene gene265 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00266 S101447_00267 S101447_00267 S101447_00267 285041 286435 + putative 4-hydroxybenzoate transporter PcaK Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the major facilitator superfamily. Aromatic acid:H(+) symporter (AAHS) (TC 2. A. 1. 15) family gene gene266 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00267 S101447_00268 S101447_00268 S101447_00268 286610 287845 + Multidrug resistance protein MdtA Cell inner membrane%3B Cell membrane%3B Membrane%3B Signal%3B Transport%3B The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene267 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00268 S101447_00269 S101447_00269 S101447_00269 287842 291033 + Efflux pump membrane transporter BepG Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B May contribute to resistance to some drugs%2C such as deoxycholate%2C sodium dodecyl sulfate and nalidixic acid%2C in the absence of BepD and BepE%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family%3B overlaps another CDS with the same product name gene gene268 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00269 S101447_00270 S101447_00270 S101447_00270 291030 294338 + Efflux pump membrane transporter BepG Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B May contribute to resistance to some drugs%2C such as deoxycholate%2C sodium dodecyl sulfate and nalidixic acid%2C in the absence of BepD and BepE%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family%3B overlaps another CDS with the same product name gene gene269 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00270 S101447_00271 S101447_00271 S101447_00271 294338 295903 + putative efflux pump outer membrane protein SepC Cell outer membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Probable outer membrane component of the SepABC efflux pump with unknown specificity. Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene270 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00271 S101447_00272 S101447_00272 S101447_00272 295989 296165 - UPF0391 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0391 family gene gene271 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00272 S101447_00273 S101447_00273 S101447_00273 296229 296462 - hypothetical protein gene gene272 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00273 S101447_00274 S101447_00274 S101447_00274 296546 297355 - Spermidine/putrescine import ATP-binding protein PotA ATP-binding%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene273 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00274 S101447_00275 S101447_00275 S101447_00275 297352 298116 - Nitrate transport permease protein NrtB Cell membrane%3B Membrane%3B Nitrate assimilation%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Probably part of a high-affinity binding-protein- dependent transport system for nitrat%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene274 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00275 S101447_00276 S101447_00276 S101447_00276 298113 299312 - hypothetical protein gene gene275 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00276 S101447_00277 S101447_00277 S101447_00277 299351 299776 - 50S ribosomal protein L17 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein L17P family gene gene276 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00277 S101447_00278 S101447_00278 rpoA rpoA 299811 300830 - DNA-directed RNA polymerase DNA-directed RNA polymerase%3B Nucleotidyltransferase%3B Transcription%3B Transferase%3B DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase alpha chain family%3B KEGG: bja:bll5376 DNA-directed RNA polymerase subunit alpha gene gene277 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00278 S101447_00279 S101447_00279 S101447_00279 300940 301332 - 30S ribosomal protein S11 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Located on the platform of the 30S subunit%2C it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome%3B Belongs to the ribosomal protein S11P family gene gene278 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00279 S101447_00280 S101447_00280 S101447_00280 301399 301776 - Cyanelle 30S ribosomal protein S13 Cyanelle%3B Plastid%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Located at the top of the head of the 30S subunit%2C it contacts several helices of the 16S rRNA%3B Belongs to the ribosomal protein S13P family gene gene279 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00280 S101447_00281 S101447_00281 S101447_00281 301890 302558 - Adenylate kinase ATP-binding%3B Cytoplasm%3B Kinase%3B Mitochondrion%3B Nucleotide-binding%3B Transferase%3B Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways%3B Belongs to the adenylate kinase family. AK2 subfamily%3B KEGG: wgl:WIGMOR_0223 adenylate kinase gene gene280 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00281 S101447_00282 S101447_00282 S101447_00282 302555 303913 - Protein translocase subunit SecY Cell membrane%3B Membrane%3B Protein transport%3B Translocation%3B Transmembrane%3B Transmembrane helix%3B Transport%3B The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7%2C and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently%3B Belongs to the SecY/SEC61-alpha family gene gene281 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00282 S101447_00283 S101447_00283 S101447_00283 304049 304537 - 50S ribosomal protein L15 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Binds to the 23S rRNA%3B Belongs to the ribosomal protein L15P family gene gene282 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00283 S101447_00284 S101447_00284 S101447_00284 304539 304724 - 50S ribosomal protein L30 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein L30P family gene gene283 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00284 S101447_00285 S101447_00285 S101447_00285 304717 305292 - 30S ribosomal protein Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B With S4 and S12 plays an important role in translational accuracy%3B Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body%3B Belongs to the ribosomal protein S5P family%3B Contains 1 S5 DRBM domain gene gene284 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00285 S101447_00286 S101447_00286 S101447_00286 305308 305670 - 50S ribosomal protein L18 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit%2C where it forms part of the central protuberance%3B Belongs to the ribosomal protein L18P family gene gene285 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00286 S101447_00287 S101447_00287 S101447_00287 305670 306203 - 50S ribosomal protein L6 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B This protein binds to the 23S rRNA%2C and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk%2C and near the tRNA binding site of the peptidyltransferase center%3B Belongs to the ribosomal protein L6P family gene gene286 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00287 S101447_00288 S101447_00288 S101447_00288 306214 306612 - 30S ribosomal protein S8 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit%3B Belongs to the ribosomal protein S8P family gene gene287 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00288 S101447_00289 S101447_00289 S101447_00289 306622 306927 - 30S ribosomal protein S14 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Binds 16S rRNA%2C required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site%3B Belongs to the ribosomal protein S14P family gene gene288 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00289 S101447_00290 S101447_00290 S101447_00290 307007 307576 - 50S ribosomal protein L5 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B tRNA-binding%3B This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit%2C where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b)%2C connecting the 2 subunit%3B this bridge is implicated in subunit movement. Contacts the P site tRN%3B the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs%3B Belongs to the ribosomal protein L5P family gene gene289 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00290 S101447_00291 S101447_00291 S101447_00291 307587 307907 - 50S ribosomal protein L24 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B One of two assembly initiator proteins%2C it binds directly to the 5'-end of the 23S rRNA%2C where it nucleates assembly of the 50S subunit%3B One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit%3B Belongs to the ribosomal protein L24P family gene gene290 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00291 S101447_00292 S101447_00292 S101447_00292 307907 308275 - 50S ribosomal protein L14 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome%3B Belongs to the ribosomal protein L14P family gene gene291 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00292 S101447_00293 S101447_00293 S101447_00293 308294 308563 - 30S ribosomal protein S17 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B One of the primary rRNA binding proteins%2C it binds specifically to the 5'-end of 16S ribosomal RNA%3B Belongs to the ribosomal protein S17P family gene gene292 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00293 S101447_00294 S101447_00294 S101447_00294 308577 308813 - 50S ribosomal protein L29 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein L29P family gene gene293 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00294 S101447_00295 S101447_00295 S101447_00295 308815 309231 - 50S ribosomal protein L16%2C chloroplastic Chloroplast%3B Plastid%3B Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein L16P family gene gene294 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00295 S101447_00296 S101447_00296 S101447_00296 309250 309927 - 30S ribosomal protein S3 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome%2C positioning it for translation%3B Belongs to the ribosomal protein S3P family%3B Contains 1 KH type-2 domain gene gene295 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00296 S101447_00297 S101447_00297 S101447_00297 309931 310341 - 50S ribosomal protein L22 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B This protein binds specifically to 23S rRN%3B its binding is stimulated by other ribosomal proteins%2C e. g. L4%2C L17%2C and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)%3B The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit%2C while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome%3B Belongs to the ribosomal protein L22P family gene gene296 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00297 S101447_00298 S101447_00298 S101447_00298 310348 310626 - 30S ribosomal protein S19%2C chloroplastic Chloroplast%3B Plastid%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA%3B Belongs to the ribosomal protein S19P family gene gene297 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00298 S101447_00299 S101447_00299 S101447_00299 310640 311470 - 50S ribosomal protein L2 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome%2C for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activit%3B this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome%3B Belongs to the ribosomal protein L2P family gene gene298 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00299 S101447_00300 S101447_00300 S101447_00300 311487 311822 - 50S ribosomal protein L23 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome%3B Belongs to the ribosomal protein L23P family gene gene299 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00300 S101447_00301 S101447_00301 S101447_00301 311819 312433 - 50S ribosomal protein L4 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B One of the primary rRNA binding proteins%2C this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome%3B Forms part of the polypeptide exit tunnel%3B Belongs to the ribosomal protein L4P family gene gene300 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00301 S101447_00302 S101447_00302 S101447_00302 312438 313121 - 50S ribosomal protein L3 Methylation%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B One of the primary rRNA binding proteins%2C it binds directly near the 3'-end of the 23S rRNA%2C where it nucleates assembly of the 50S subunit%3B Belongs to the ribosomal protein L3P family gene gene301 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00302 S101447_00303 S101447_00303 S101447_00303 313132 313440 - 30S ribosomal protein S10 Ribonucleoprotein%3B Ribosomal protein%3B Involved in the binding of tRNA to the ribosomes%3B Belongs to the ribosomal protein S10P family gene gene302 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00303 S101447_00304 S101447_00304 S101447_00304 313548 314738 - Elongation factor Tu Cytoplasm%3B Elongation factor%3B GTP-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene303 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00304 S101447_00305 S101447_00305 S101447_00305 314829 315305 - 30S ribosomal protein S7 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B tRNA-binding%3B One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center%2C probably blocks exit of the E-site tRNA%3B Belongs to the ribosomal protein S7P family gene gene304 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00305 S101447_00306 S101447_00306 S101447_00306 315320 315691 - 30S ribosomal protein S12%2C chloroplastic Chloroplast%3B Plastid%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits (By similarity)%3B Belongs to the ribosomal protein S12P family gene gene305 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00306 S101447_00307 S101447_00307 rpoC rpoC 316030 320205 - DNA-directed RNA polymerase DNA-directed RNA polymerase%3B Nucleotidyltransferase%3B Transcription%3B Transferase%3B DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase beta' chain family%3B KEGG: pae:PA4269 DNA-directed RNA polymerase subunit beta' gene gene306 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00307 S101447_00308 S101447_00308 rpoB rpoB 320299 324471 - DNA-directed RNA polymerase DNA-directed RNA polymerase%3B Nucleotidyltransferase%3B Transcription%3B Transferase%3B DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase beta chain family%3B KEGG: gox:GOX0386 DNA-directed RNA polymerase subunit beta gene gene307 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00308 S101447_00309 S101447_00309 S101447_00309 324691 325065 - 50S ribosomal protein L7/L12 Ribonucleoprotein%3B Ribosomal protein%3B Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation%3B Belongs to the ribosomal protein L7/L12P family gene gene308 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00309 S101447_00310 S101447_00310 S101447_00310 325166 325684 - 50S ribosomal protein L10 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Forms part of the ribosomal stalk%2C playing a central role in the interaction of the ribosome with GTP-bound translation factors%3B Belongs to the ribosomal protein L10P family gene gene309 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00310 S101447_00311 S101447_00311 S101447_00311 325964 326656 - 50S ribosomal protein L1 Repressor%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Translation regulation%3B tRNA-binding%3B Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome%2C and is involved in E site tRNA release%3B Protein L1 is also a translational repressor protein%2C it controls the translation of the L11 operon by binding to its mRNA%3B Belongs to the ribosomal protein L1P family gene gene310 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00311 S101447_00312 S101447_00312 S101447_00312 326663 327097 - 50S ribosomal protein L11 Methylation%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors%3B Belongs to the ribosomal protein L11P family gene gene311 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00312 S101447_00313 S101447_00313 S101447_00313 327202 328812 - Antibiotic efflux pump outer membrane protein ArpC Antibiotic resistance%3B Cell outer membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B The outer membrane component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin%2C chloramphenicol%2C erythromycin%2C novobiocin%2C streptomycin and tetracycline. Is not involved in organic solvent efflux. Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene312 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00313 S101447_00314 S101447_00314 S101447_00314 328809 330161 - Multidrug resistance protein MdtA Cell inner membrane%3B Cell membrane%3B Membrane%3B Signal%3B Transport%3B The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene313 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00314 S101447_00315 S101447_00315 S101447_00315 330158 333331 - Multidrug resistance protein MdtB Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MdtB subfamily gene gene314 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00315 S101447_00316 S101447_00316 S101447_00316 333429 334820 - Sensor kinase CusS ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Copper%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system%3B Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Activates CusR by phosphorylation (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: gox:GOX0394 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene315 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00316 S101447_00317 S101447_00317 S101447_00317 334807 335538 - Acid tolerance regulatory protein ActR DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system%3B Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two- component sensor may be involved in pH sensing and/or response (By similarity)%3B Contains 1 response regulatory domain gene gene316 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00317 S101447_00318 S101447_00318 S101447_00318 335542 336813 - DNA recombination protein RmuC like protein Coiled coil%3B DNA recombination%3B Involved in DNA recombination%3B Belongs to the RmuC family gene gene317 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00318 S101447_00319 S101447_00319 S101447_00319 337050 338333 + Alpha-ketoglutarate permease Cell inner membrane%3B Cell membrane%3B Membrane%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system)%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family gene gene318 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00319 S101447_00320 S101447_00320 S101447_00320 338532 338936 + hypothetical protein gene gene319 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00320 S101447_00321 S101447_00321 prxQ prxQ 338960 339448 - Peroxiredoxin Oxidoreductase%3B Peroxidase%3B Redox-active center%3B Belongs to the AhpC/TSA family%3B Contains 1 thioredoxin domain%3B KEGG: apt:APA01_09130 peroxiredoxin Q/BCP gene gene320 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00321 S101447_00322 S101447_00322 glnE glnE 339530 342544 - [Glutamate--ammonia-ligase] adenylyltransferase ATP-binding%3B Magnesium%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Repeat%3B Transferase%3B Adenylation and deadenylation of glutamate--ammonia ligase%3B Belongs to the GlnE family%3B KEGG: apt:APA01_09120 glutamate-ammonia-ligase adenylyltransferase gene gene321 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00322 S101447_00323 S101447_00323 S101447_00323 342646 345909 + hypothetical protein gene gene322 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00323 S101447_00324 S101447_00324 S101447_00324 345952 346503 - hypothetical protein gene gene323 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00324 S101447_00325 S101447_00325 S101447_00325 346550 347179 - hypothetical protein gene gene324 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00325 S101447_00326 S101447_00326 S101447_00326 347181 347975 - hypothetical protein gene gene325 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00326 S101447_00327 S101447_00327 S101447_00327 348090 348770 - Leucyltransferase Acyltransferase%3B Cytoplasm%3B Transferase%3B Functions in the N-end rule pathway of protein degradation where it conjugates Leu%2C Phe and%2C less efficiently%2C Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine%3B Belongs to the L/F-transferase family%3B KEGG: mcg:GL4_1734 leucyl/phenylalanyl-tRNA--protein transferase gene gene326 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00327 S101447_00328 S101447_00328 S101447_00328 348909 349883 + Gluconate 2-dehydrogenase NAD%3B Oxidoreductase%3B Active on hydroxypyruvate and glyoxylate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: gan:UMN179_01694 gluconate 2-dehydrogenase gene gene327 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00328 S101447_00329 S101447_00329 S101447_00329 349899 350075 + hypothetical protein gene gene328 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00329 S101447_00330 S101447_00330 S101447_00330 350145 350978 - hypothetical protein gene gene329 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00330 S101447_00331 S101447_00331 S101447_00331 351229 351906 + hypothetical protein gene gene330 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00331 S101447_00332 S101447_00332 S101447_00332 352017 352352 + Beta-lactamase hydrolase-like protein Hydrolase%3B Belongs to the metallo-beta-lactamase superfamily%3B KEGG: sno:Snov_0987 sulfide:quinone oxidoreductase%3B With a quinone or similar compound as acceptor gene gene331 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00332 S101447_00333 S101447_00333 S101447_00333 352461 352880 - hypothetical protein gene gene332 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00333 S101447_00334 S101447_00334 S101447_00334 352883 353176 - hypothetical protein gene gene333 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00334 S101447_00335 S101447_00335 S101447_00335 353348 354121 + Heme exporter protein Cell inner membrane%3B Cell membrane%3B Cytochrome c-type biogenesis%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes%3B Belongs to the CcmC/CycZ/HelC family gene gene334 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00335 S101447_00336 S101447_00336 S101447_00336 354118 354279 + hypothetical protein gene gene335 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00336 S101447_00337 S101447_00337 S101447_00337 354276 354806 + Cytochrome c-type bioproteinis protein CcmE Cell inner membrane%3B Cell membrane%3B Cytochrome c-type biogenesis%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Signal-anchor%3B Transmembrane%3B Transmembrane helix%3B Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH%3B Belongs to the CcmE/CycJ family gene gene336 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00337 S101447_00338 S101447_00338 S101447_00338 354844 356829 + Cytochrome c-type bioproteinis protein CcmF Cell inner membrane%3B Cell membrane%3B Cytochrome c-type biogenesis%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase (By similarity)%3B Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family gene gene337 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00338 S101447_00339 S101447_00339 S101447_00339 356826 357407 + Thiol:disulfide interchange protein DsbE like protein Cytochrome c-type biogenesis%3B Disulfide bond%3B Periplasm%3B Redox-active center%3B Signal%3B Required for disulfide bond formation in some periplasmic proteins. Also act as a disulfide oxidoreductase in cytochromes c biogenesis. The cysteines of apocytochromes c must be in the reduced state for covalent linkage between the two moieties to occur. Belongs to the thioredoxin family. DsbE subfamily%3B Contains 1 thioredoxin domain gene gene338 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00339 S101447_00340 S101447_00340 S101447_00340 357404 357895 + Cytochrome c-type bioproteinis protein CcmH Cytochrome c-type biogenesis%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Signal%3B Transmembrane%3B Transmembrane helix%3B Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. Belongs to the CcmH/CycL/Ccl2/NrfF family gene gene339 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00340 S101447_00341 S101447_00341 S101447_00341 357892 358623 + hypothetical protein gene gene340 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00341 S101447_00342 S101447_00342 S101447_00342 358653 359180 - hypothetical protein gene gene341 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00342 S101447_00343 S101447_00343 S101447_00343 359254 359628 - hypothetical protein gene gene342 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00343 S101447_00344 S101447_00344 S101447_00344 359885 362056 + putative transporter Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the aromatic acid exporter ArAE (TC 2. A. 85) family gene gene343 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00344 S101447_00345 S101447_00345 S101447_00345 362168 364372 + putative transporter YdhK Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the aromatic acid exporter ArAE (TC 2. A. 85) family gene gene344 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00345 S101447_00346 S101447_00346 S101447_00346 364384 365400 - Inward rectifier potassium channel Kirbac3.1 Ion channel%3B Ion transport%3B Membrane%3B Potassium%3B Potassium transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Voltage-gated channel%3B Inward rectifier potassium channel that mediates potassium uptake into the cell. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification may be achieved by the blockage of outward current by cytoplasmic divalent metal ions and polyamines. Complements an E. coli mutant that is defective in K(+) uptake%3B Belongs to the inward rectifier-type potassium channel (TC 1. A. 2. 1) family. KCNJ11 subfamily gene gene345 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00346 S101447_00347 S101447_00347 S101447_00347 365541 366917 - Hyaluronoglucosaminidase KEGG: bfo:BRAFLDRAFT_81185 cell migration-inducing and hyaluronan-binding protein gene gene346 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00347 S101447_00348 S101447_00348 S101447_00348 366946 367884 - hypothetical protein gene gene347 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00348 S101447_00349 S101447_00349 S101447_00349 367881 368831 - hypothetical protein gene gene348 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00349 S101447_00350 S101447_00350 S101447_00350 368831 369532 - hypothetical protein gene gene349 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00350 S101447_00351 S101447_00351 S101447_00351 369534 370430 - hypothetical protein gene gene350 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00351 S101447_00352 S101447_00352 S101447_00352 370427 372745 - Adenylate cyclase cGMP biosynthesis%3B Chemotaxis%3B GTP-binding%3B Lyase%3B Magnesium%3B Membrane%3B Metal-binding%3B Nucleotide-binding%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Synthesizes cyclic GMP (cGMP) from GTP%2C after activation by heterotrimeric or monomeric G proteins. Involved in chemotaxis. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family%3B Contains 2 guanylate cyclase domains%3B KEGG: gox:GOX2023 adenylate cyclase gene gene351 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00352 S101447_00353 S101447_00353 S101447_00353 372916 374406 - Exopolyphosphatase Hydrolase%3B Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response'%2C an adaptive process that allows bacteria to respond to amino acid starvation%2C resulting in the coordinated regulation of numerous cellular activities%3B Belongs to the GppA/Ppx family. GppA subfamily%3B KEGG: apt:APA01_08810 exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase gene gene352 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00353 S101447_00354 S101447_00354 S101447_00354 374504 376789 - Polyphosphate kinase ATP-binding%3B Kinase%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)%3B Belongs to the polyphosphate kinase family%3B KEGG: apt:APA01_08800 polyphosphate kinase gene gene353 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00354 S101447_00355 S101447_00355 S101447_00355 376950 377717 - hypothetical protein gene gene354 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00355 S101447_00356 S101447_00356 purM purM 377829 378911 + Phosphoribosylformylglycinamidine cyclo-ligase ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Purine biosynthesis%3B Belongs to the AIR synthase family%3B KEGG: apt:APA01_08780 phosphoribosylformylglycinamidine cyclo-ligase gene gene355 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00356 S101447_00357 S101447_00357 purN purN 378908 379531 + Phosphoribosylglycinamide formyltransferase Acetylation%3B ATP-binding%3B Ligase%3B Manganese%3B Metal-binding%3B Multifunctional enzyme%3B Nucleotide-binding%3B Phosphoprotein%3B Polymorphism%3B Purine biosynthesis%3B Transferase%3B In the N-terminal sectio%3B belongs to the GARS family%3B In the central sectio%3B belongs to the AIR synthase family%3B In the C-terminal sectio%3B belongs to the GART family%3B Contains 1 ATP-grasp domain%3B KEGG: apt:APA01_08770 phosphoribosylglycinamide formyltransferase 1 gene gene356 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00357 S101447_00358 S101447_00358 rsmB rsmB 379577 380899 + 16S rRNA (cytosine(967)-C(5))-methyltransferase Cytoplasm%3B Methyltransferase%3B Ribosome biogenesis%3B RNA-binding%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family%3B KEGG: apt:APA01_08760 16S rRNA (cytosine967-C5)-methyltransferase gene gene357 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00358 S101447_00359 S101447_00359 S101447_00359 380973 381650 + Ribulose-phosphate 3-epimerase Carbohydrate metabolism%3B Cobalt%3B Iron%3B Isomerase%3B Manganese%3B Metal-binding%3B Zinc%3B Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate%3B Belongs to the ribulose-phosphate 3-epimerase family%3B KEGG: apt:APA01_08750 ribulose-phosphate 3-epimerase gene gene358 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00359 S101447_00360 S101447_00360 S101447_00360 381751 383538 + hypothetical protein gene gene359 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00360 S101447_00361 S101447_00361 pglA pglA 383548 384657 + N%2CN'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1%2C3-N-acetylgalactosaminyltransferase Antibiotic biosynthesis%3B Glycosyltransferase%3B Transferase%3B Glycosyltransferase involved in the biosynthesis of butirosin by mediating conversion of 2-deoxystreptamine (2-DOS) to 2'-N-acetylparomamine using UDP-alpha-D-glucosamine as sugar donor%3B Belongs to the glycosyltransferase group 1 family%3B KEGG: cco:CCC13826_0451 N%2CN'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1%2C3-N-acetylgalactosaminyltransferase gene gene360 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00361 S101447_00362 S101447_00362 S101447_00362 384683 385180 - hypothetical protein gene gene361 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00362 S101447_00363 S101447_00363 dnaQ dnaQ 385361 386035 - DNA-directed DNA polymerase DNA replication%3B DNA-directed DNA polymerase%3B Exonuclease%3B Hydrolase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nuclease%3B Nucleotidyltransferase%3B Transferase%3B DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease (By similarity)%3B KEGG: gox:GOX1961 DNA polymerase III subunit epsilon gene gene362 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00363 S101447_00364 S101447_00364 coaE coaE 386032 386619 - Dephospho-CoA kinase ATP-binding%3B Coenzyme A biosynthesis%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A%3B Belongs to the CoaE family%3B Contains 1 DPCK (dephospho-CoA kinase) domain%3B KEGG: rpi:Rpic_3073 dephospho-CoA kinase gene gene363 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00364 S101447_00365 S101447_00365 aroE aroE 386636 387502 - Shikimate dehydrogenase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B NADP%3B Oxidoreductase%3B Involved in the biosynthesis of the chorismate%2C which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)%3B Belongs to the shikimate dehydrogenase family%3B KEGG: apt:APA01_08690 shikimate dehydrogenase gene gene364 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00365 S101447_00366 S101447_00366 S101447_00366 387499 388278 - N-formylglutamate deformylase KEGG: zmo:ZMO1181 N-formylglutamate deformylase gene gene365 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00366 S101447_00367 S101447_00367 S101447_00367 388381 388695 - hypothetical protein gene gene366 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00367 S101447_00368 S101447_00368 argH argH 388941 390389 + Argininosuccinate lyase Amino-acid biosynthesis%3B Arginine biosynthesis%3B Cytoplasm%3B Lyase%3B Belongs to the lyase 1 family. Argininosuccinate lyase subfamily%3B KEGG: apt:APA01_08650 argininosuccinate lyase gene gene367 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00368 S101447_00369 S101447_00369 S101447_00369 390394 390537 + hypothetical protein gene gene368 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00369 S101447_00370 S101447_00370 lysA lysA 390654 391997 + Diaminopimelate decarboxylase Amino-acid biosynthesis%3B Decarboxylase%3B Lyase%3B Lysine biosynthesis%3B Pyridoxal phosphate%3B Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine%3B Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily%3B KEGG: apt:APA01_08630 diaminopimelate decarboxylase gene gene369 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00370 S101447_00371 S101447_00371 S101447_00371 391994 394792 + hypothetical protein gene gene370 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00371 S101447_00372 S101447_00372 galE galE 394882 395868 + UDP-glucose 4-epimerase Carbohydrate metabolism%3B Exopolysaccharide synthesis%3B Galactose metabolism%3B Isomerase%3B NAD%3B Plasmid%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: apt:APA01_08610 UDP-glucose 4-epimerase gene gene371 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00372 S101447_00373 S101447_00373 ydgD ydgD 395858 396619 + putative serine protease YdgD Hydrolase%3B Protease%3B Serine protease%3B Signal%3B Belongs to the peptidase S1B family%3B KEGG: apt:APA01_08600 protease YdgD%3B Serine endopeptidases gene gene372 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00373 S101447_00374 S101447_00374 adhP adhP 396735 397718 + Alcohol dehydrogenase Metal-binding%3B Oxidoreductase%3B Zinc%3B Belongs to the zinc-containing alcohol dehydrogenase family%3B KEGG: apt:APA01_08590 alcohol dehydrogenase%2C propanol-preferring gene gene373 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00374 S101447_00375 S101447_00375 S101447_00375 397735 398067 - putative HTH-type transcriptional regulator YczG DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Contains 1 HTH arsR-type DNA-binding domain gene gene374 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00375 S101447_00376 S101447_00376 S101447_00376 398164 399255 + Anthraniloyl-CoA monooxygenase Detoxification%3B Flavoprotein%3B FMN%3B NADP%3B Oxidoreductase%3B Catalyzes the reduction of the double bond of an array of alpha%2Cbeta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes%3B Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily%3B KEGG: pdx:Psed_4248 anthraniloyl-CoA monooxygenase gene gene375 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00376 S101447_00377 S101447_00377 panB panB 399315 400133 - 3-methyl-2-oxobutanoate hydroxymethyltransferase Cytoplasm%3B Magnesium%3B Metal-binding%3B Pantothenate biosynthesis%3B Transferase%3B Catalyzes the reversible reaction in which hydroxymethyl group from 5%2C10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate%3B Belongs to the PanB family%3B KEGG: apt:APA01_08560 3-methyl-2-oxobutanoate hydroxymethyltransferase gene gene376 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00377 S101447_00378 S101447_00378 S101447_00378 400319 400404 + tRNA-Tyr tRNA gene377 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00378 S101447_00379 S101447_00379 S101447_00379 400801 402396 + hypothetical protein gene gene378 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00379 S101447_00380 S101447_00380 S101447_00380 402787 403422 + hypothetical protein gene gene379 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00380 S101447_00381 S101447_00381 S101447_00381 403397 403780 + hypothetical protein gene gene380 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00381 S101447_00382 S101447_00382 S101447_00382 403915 404292 - hypothetical protein gene gene381 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00382 S101447_00383 S101447_00383 S101447_00383 404340 404879 - hypothetical protein gene gene382 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00383 S101447_00384 S101447_00384 S101447_00384 405082 405381 + hypothetical protein gene gene383 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00384 S101447_00385 S101447_00385 S101447_00385 405778 406665 - hypothetical protein gene gene384 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00385 S101447_00386 S101447_00386 S101447_00386 407032 408882 + hypothetical protein gene gene385 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00386 S101447_00387 S101447_00387 S101447_00387 408884 410197 + hypothetical protein gene gene386 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00387 S101447_00388 S101447_00388 S101447_00388 410166 410534 + hypothetical protein gene gene387 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00388 S101447_00389 S101447_00389 gabD gabD 410715 412106 - Succinate-semialdehyde dehydrogenase (NAD(P)(+)) NAD%3B Oxidoreductase%3B Stress response%3B Belongs to the aldehyde dehydrogenase family%3B KEGG: ecle:ECNIH2_24840 succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase gene gene388 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00389 S101447_00390 S101447_00390 yqhD yqhD 412191 413348 - Alcohol dehydrogenase YqhD Metal-binding%3B NADP%3B Oxidoreductase%3B Zinc%3B NADP-dependent ADH activity%3B Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: pay:PAU_02906 NADP-dependent alcohol dehydrogenase%3B Acting on the CH-OH group of donors gene gene389 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00390 S101447_00391 S101447_00391 S101447_00391 413436 414029 - Transcriptional regulator AcuR DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B A transcriptional repressor for its operon. Probably binds to 2 operator sequences in the promoter%3B Contains 1 HTH tetR-type DNA-binding domain gene gene390 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00391 S101447_00392 S101447_00392 S101447_00392 414328 415224 + Ornithine cyclodeaminase NADP%3B Oxidoreductase%3B Catalyzes the reduction of Delta(1)-pyrroline-2- carboxylate (Pyr2C) to L-proline%2C using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline%3B Belongs to the ornithine cyclodeaminase/mu-crystallin family%3B KEGG: apt:APA01_08140 ornithine cyclodeaminase gene gene391 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00392 S101447_00393 S101447_00393 nfnB nfnB 415377 416027 + Major NAD(P)H-flavin oxidoreductase FAD%3B Flavoprotein%3B FMN%3B Luminescence%3B NAD%3B NADP%3B Oxidoreductase%3B Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction. Major FMN reductase. It is capable of using both NADH and NADPH as electron donors. As electron acceptor%2C FMN is the most effective%2C FAD is considerably effective%2C and riboflavin is the least effective. Belongs to the nitroreductase family%3B KEGG: apt:APA01_08130 nitroreductase / dihydropteridine reductase%3B Oxidoreductases gene gene392 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00393 S101447_00394 S101447_00394 S101447_00394 415941 416174 - hypothetical protein gene gene393 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00394 S101447_00395 S101447_00395 S101447_00395 416272 416625 + hypothetical protein gene gene394 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00395 S101447_00396 S101447_00396 S101447_00396 416636 417271 - putative membrane protein YrhP Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the rht family gene gene395 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00396 S101447_00397 S101447_00397 S101447_00397 417414 417935 - hypothetical protein gene gene396 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00397 S101447_00398 S101447_00398 mtaP mtaP 418041 418925 - S-methyl-5'-thioadenosine phosphorylase Glycosyltransferase%3B Purine salvage%3B Transferase%3B Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA%2C a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates%3B Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily%3B KEGG: apt:APA01_08090 5'-methylthioadenosine phosphorylase gene gene397 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00398 S101447_00399 S101447_00399 S101447_00399 418912 419703 - Cytochrome c1 Cell membrane%3B Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Respiratory chain%3B Signal%3B Transmembrane%3B Transmembrane helix%3B Transport. gene gene398 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00399 S101447_00400 S101447_00400 S101447_00400 419700 420923 - Cytochrome b/c1 Cell inner membrane%3B Cell membrane%3B Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex)%2C which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. c1 functions as an electron donor to cytochrome c. Belongs to the cytochrome b family%3B Contains 1 cytochrome c domain gene gene399 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00400 S101447_00401 S101447_00401 cpoX cpoX 421062 421976 + Coproporphyrinogen oxidase Cytoplasm%3B Heme biosynthesis%3B Metal-binding%3B Oxidoreductase%3B Porphyrin biosynthesis%3B Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX%3B Belongs to the aerobic coproporphyrinogen-III oxidase family%3B KEGG: apt:APA01_08060 coproporphyrinogen III oxidase gene gene400 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00401 S101447_00402 S101447_00402 S101447_00402 422014 423201 + hypothetical protein gene gene401 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00402 S101447_00403 S101447_00403 S101447_00403 423181 423813 - hypothetical protein gene gene402 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00403 S101447_00404 S101447_00404 S101447_00404 423949 425376 - Cytochrome-c peroxidase Electron transport%3B Heme%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Peroxidase%3B Transport%3B KEGG: apt:APA01_08030 cytochrome c peroxidase gene gene403 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00404 S101447_00405 S101447_00405 S101447_00405 425511 426269 - Site-specific DNA-methyltransferase (adenine-specific) Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Methylates the second adenine of the NsiI recognition sequence (5'-ATGCAT-3')%3B Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: apt:APA01_08020 site-specific DNA-methyltransferase (adenine-specific) gene gene404 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00405 S101447_00406 S101447_00406 S101447_00406 426365 427045 - hypothetical protein gene gene405 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00406 S101447_00407 S101447_00407 gpmB gpmB 427206 427724 + Phosphoglycerate mutase (2%2C3-diphosphoglycerate-independent) KEGG: ica:Intca_3324 probable phosphoglycerate mutase gene gene406 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00407 S101447_00408 S101447_00408 S101447_00408 427851 428348 + Protein-export protein SecB Chaperone%3B Cytoplasm%3B Protein transport%3B Translocation%3B Transport%3B One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins%2C maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA%3B Belongs to the SecB family gene gene407 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00408 S101447_00409 S101447_00409 hemD hemD 428411 429139 - Uroporphyrinogen-III synthase KEGG: apt:APA01_07980 uroporphyrinogen-III synthase gene gene408 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00409 S101447_00410 S101447_00410 hemC hemC 429149 430222 - Hydroxymethylbilane synthase Chlorophyll biosynthesis%3B Chloroplast%3B Phosphoprotein%3B Plastid%3B Porphyrin biosynthesis%3B Transferase%3B Transit peptide%3B Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps%3B Belongs to the HMBS family%3B KEGG: apt:APA01_07970 hydroxymethylbilane synthase gene gene409 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00410 S101447_00411 S101447_00411 kae1 kae1 430368 431474 + N(6)-L-threonylcarbamoyladenine synthase Acyltransferase%3B Cytoplasm%3B Iron%3B Metal-binding%3B Transferase%3B tRNA processing%3B Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37%2C together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction%3B Belongs to the KAE1 / TsaD family%3B KEGG: apt:APA01_07960 N6-L-threonylcarbamoyladenine synthase gene gene410 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00411 S101447_00412 S101447_00412 rlmJ rlmJ 431471 432292 + 23S rRNA (adenine(2030)-N(6))-methyltransferase Methyltransferase%3B RNA-binding%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Specifically methylates the adenine in position 2030 of 23S rRNA. Nascent 23S rRNA seems to be the natural substrate. Appears to be not necessary for ribosome assembly. Seems to be required for the utilization of extracellular DNA as the sole source of carbon and energy%3B Belongs to the RlmJ family%3B KEGG: eco:b3499 23S rRNA (adenine2030-N6)-methyltransferase gene gene411 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00412 S101447_00413 S101447_00413 S101447_00413 432307 433044 - UPF0056 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0056 (MarC) family gene gene412 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00413 S101447_00414 S101447_00414 S101447_00414 433102 435189 - uncharacterized protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B To E. coli YbhN gene gene413 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00414 S101447_00415 S101447_00415 lysK lysK 435210 436835 - Lysine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: apt:APA01_07920 lysyl-tRNA synthetase%2C class I gene gene414 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00415 S101447_00416 S101447_00416 S101447_00416 436994 437749 + Nicotinamide-nucleotide amidase Alternative splicing%3B ATP-binding%3B FAD%3B Flavoprotein%3B FMN%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase%3B Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme%3B In the N-terminal sectio%3B belongs to the MoaB/Mog family%3B In the C-terminal sectio%3B belongs to the PAPS reductase family. FAD1 subfamily%3B KEGG: scu:SCE1572_47505 nicotinamide-nucleotide amidase gene gene415 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00416 S101447_00417 S101447_00417 accA accA 437806 438762 - Acetyl-CoA carboxylase ATP-binding%3B Cytoplasm%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Ligase%3B Lipid biosynthesis%3B Lipid metabolism%3B Nucleotide-binding%3B Component of the acetyl coenzyme A carboxylase (ACC) complex. First%2C biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA%3B Belongs to the AccA family%3B KEGG: gdj:Gdia_0400 acetyl-CoA carboxylase carboxyl transferase subunit alpha gene gene416 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00417 S101447_00418 S101447_00418 S101447_00418 438837 439757 - Tyrosine recombinase XerD Cell cycle%3B Cell division%3B Chromosome partition%3B Cytoplasm%3B DNA integration%3B DNA recombination%3B DNA-binding%3B Site-specific tyrosine recombinase%2C which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids%3B Belongs to the 'phage' integrase family. XerD subfamily gene gene417 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00418 S101447_00419 S101447_00419 S101447_00419 439761 440099 - Vegetative cell wall protein gp1 Glycoprotein%3B Repeat%3B Signal. gene gene418 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00419 S101447_00420 S101447_00420 S101447_00420 440162 441895 + Shikimate kinase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Belongs to the shikimate kinase family%3B KEGG: apt:APA01_07870 shikimate kinase / 3-dehydroquinate synthase gene gene419 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00420 S101447_00421 S101447_00421 S101447_00421 442240 443367 + Outer membrane protein Cell outer membrane%3B Lipoprotein%3B Membrane%3B Signal%3B Growth enhancer%3B Contains 1 OmpA-like domain gene gene420 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00421 S101447_00422 S101447_00422 S101447_00422 443467 443970 + hypothetical protein gene gene421 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00422 S101447_00423 S101447_00423 aarS aarS 444107 446788 + Alanine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B RNA-binding%3B tRNA-binding%3B Zinc%3B Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: apk:APA386B_2290 alanyl-tRNA synthetase gene gene422 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00423 S101447_00424 S101447_00424 pisD pisD 446870 447559 + Phosphatidylserine decarboxylase Decarboxylase%3B Lipid biosynthesis%3B Lipid metabolism%3B Lyase%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Pyruvate%3B Zymogen%3B Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily%3B KEGG: apt:APA01_07830 phosphatidylserine decarboxylase gene gene423 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00424 S101447_00425 S101447_00425 cho1 cho1 447572 448477 + CDP-diacylglycerol--serine O-phosphatidyltransferase Cell membrane%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Belongs to the CDP-alcohol phosphatidyltransferase class-I family%3B KEGG: apt:APA01_07820 CDP-diacylglycerol---serine O-phosphatidyltransferase gene gene424 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00425 S101447_00426 S101447_00426 mbhJ mbhJ 448466 448963 - Ferredoxin hydrogenase 4Fe-4S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase%3B Belongs to the complex I 20 kDa subunit family%3B KEGG: mhu:Mhun_2588 membrane-bound hydrogenase subunit mbhJ gene gene425 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00426 S101447_00427 S101447_00427 S101447_00427 448999 450495 - NADH-quinone oxidoreductase subunit D Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transport%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I 49 kDa subunit family gene gene426 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00427 S101447_00428 S101447_00428 S101447_00428 450497 451630 - hypothetical protein gene gene427 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00428 S101447_00429 S101447_00429 S101447_00429 451627 452217 - hypothetical protein gene gene428 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00429 S101447_00430 S101447_00430 S101447_00430 452214 453230 - hypothetical protein gene gene429 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00430 S101447_00431 S101447_00431 S101447_00431 453227 454960 - hypothetical protein gene gene430 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00431 S101447_00432 S101447_00432 S101447_00432 454985 455758 - ATP synthase subunits region ORF gene gene431 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00432 S101447_00433 S101447_00433 gloB gloB 455841 456566 + Hydroxyacylglutathione hydrolase Hydrolase%3B Metal-binding%3B Zinc%3B Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid%3B Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family%3B KEGG: zmo:ZMO0759 hydroxyacylglutathione hydrolase gene gene432 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00433 S101447_00434 S101447_00434 S101447_00434 456572 457654 - hypothetical protein gene gene433 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00434 S101447_00435 S101447_00435 S101447_00435 457994 458704 - 1-acylglycerol-3-phosphate O-acyltransferase Acyltransferase%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position. This enzyme shows a preference for medium-chain-length fatty acyl-coenzyme a substrates. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family%3B KEGG: rbt:NOVO_01020 1-acyl-sn-glycerol-3-phosphate acyltransferase gene gene434 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00435 S101447_00436 S101447_00436 ahcY ahcY 458886 460175 + Adenosylhomocysteinase Cytoplasm%3B Hydrolase%3B NAD%3B One-carbon metabolism%3B Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reaction%3B therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Belongs to the adenosylhomocysteinase family%3B KEGG: mbs:MRBBS_3099 adenosylhomocysteinase gene gene435 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00436 S101447_00437 S101447_00437 S101447_00437 460441 460836 + hypothetical protein gene gene436 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00437 S101447_00438 S101447_00438 S101447_00438 460986 462020 - hypothetical protein gene gene437 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00438 S101447_00439 S101447_00439 S101447_00439 462086 463807 - Dihydrolipoyllysine-residue succinyltransferase Acyltransferase%3B Lipoyl%3B Transferase%3B Tricarboxylic acid cycle%3B The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B Belongs to the 2-oxoacid dehydrogenase family%3B Contains 1 lipoyl-binding domain%3B KEGG: hin:HI1661 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) gene gene438 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00439 S101447_00440 S101447_00440 S101447_00440 463888 465129 - Dihydrolipoyllysine-residue succinyltransferase Acyltransferase%3B Lipoyl%3B Transferase%3B Tricarboxylic acid cycle%3B The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B Belongs to the 2-oxoacid dehydrogenase family%3B Contains 1 lipoyl-binding domain%3B KEGG: hin:HI1661 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) gene gene439 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00440 S101447_00441 S101447_00441 ogdH ogdH 465239 468112 - Oxoglutarate dehydrogenase (succinyl-transferring) Glycolysis%3B Oxidoreductase%3B Thiamine pyrophosphate%3B The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)%3B Belongs to the alpha-ketoglutarate dehydrogenase family%3B KEGG: apt:APA01_07660 2-oxoglutarate dehydrogenase E1 component gene gene440 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00441 S101447_00442 S101447_00442 S101447_00442 468322 469671 - Cell division protein ZapE ATP-binding%3B Cell cycle%3B Cell division%3B Cytoplasm%3B Hydrolase%3B Nucleotide-binding%3B Reduces the stability of FtsZ polymers in the presence of ATP%3B Belongs to the AFG1 ATPase family. ZapE subfamily gene gene441 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00442 S101447_00443 S101447_00443 pcaC pcaC 469689 470027 + 4-carboxymuconolactone decarboxylase KEGG: lsa:LSA1776 4-carboxymuconolactone decarboxylase gene gene442 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00443 S101447_00444 S101447_00444 S101447_00444 470040 472238 - hypothetical protein gene gene443 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00444 S101447_00445 S101447_00445 earS earS 472277 473683 + Glutamate--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B Zinc%3B Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: lpn:lpg1911 glutamyl-tRNA synthetase gene gene444 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00445 S101447_00446 S101447_00446 pyrB pyrB 473676 474617 + Aspartate carbamoyltransferase Pyrimidine biosynthesis%3B Transferase%3B Belongs to the ATCase/OTCase family%3B KEGG: apt:APA01_07610 aspartate carbamoyltransferase catalytic subunit gene gene445 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00446 S101447_00447 S101447_00447 ura4 ura4 474614 475906 + Dihydroorotase Hydrolase%3B Metal-binding%3B Pyrimidine biosynthesis%3B Zinc%3B Belongs to the DHOase family. Type 2 subfamily%3B KEGG: apt:APA01_07600 dihydroorotase gene gene446 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00447 S101447_00448 S101447_00448 plsY plsY 475906 476547 + Glycerol-3-phosphate 1-O-acyltransferase Cell inner membrane%3B Cell membrane%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor%2C but not acyl-CoA or acyl-ACP%3B Belongs to the PlsY family%3B KEGG: apt:APA01_07590 glycerol-3-phosphate acyltransferase PlsY gene gene447 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00448 S101447_00449 S101447_00449 S101447_00449 476578 477816 + Protein smf Belongs to the smf family gene gene448 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00449 S101447_00450 S101447_00450 topA topA 477846 480539 + DNA topoisomerase DNA-binding%3B Isomerase%3B Magnesium%3B Metal-binding%3B Repeat%3B Topoisomerase%3B Zinc%3B Zinc-finger%3B Releases the supercoiling and torsional tension of DNA%2C which is introduced during the DNA replication and transcription%2C by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme%2C resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand%2C thus removing DNA supercoils. Finally%2C in the religation step%2C the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone%3B Belongs to the type IA topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: pman:OU5_P0423 DNA topoisomerase I gene gene449 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00450 S101447_00451 S101447_00451 vacB vacB 480546 482576 + Ribonuclease Cytoplasm%3B Exonuclease%3B Hydrolase%3B Nuclease%3B RNA-binding%3B 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs%3B Belongs to the RNR ribonuclease family. RNase R subfamily%3B KEGG: apt:APA01_07520 ribonuclease R%3B Acting on ester bonds gene gene450 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00451 S101447_00452 S101447_00452 S101447_00452 482566 484281 + C-terminal processing peptidase Hydrolase%3B Protease%3B Secreted%3B Serine protease%3B Signal%3B Involved in protection of the bacterium from thermal and osmotic stresses%3B Belongs to the peptidase S41A family%3B Contains 1 PDZ (DHR) domain%3B KEGG: apk:APA386B_2259 carboxyl-terminal processing protease gene gene451 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00452 S101447_00453 S101447_00453 guaA guaA 484292 484633 + GMP synthase (glutamine-hydrolyzing) KEGG: rpm:RSPPHO_02775 GMP synthase (glutamine-hydrolysing) gene gene452 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00453 S101447_00454 S101447_00454 S101447_00454 484549 484764 - hypothetical protein gene gene453 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00454 S101447_00455 S101447_00455 S101447_00455 484835 485998 + Outer membrane protein Cell outer membrane%3B Lipoprotein%3B Membrane%3B Signal%3B Growth enhancer%3B Contains 1 OmpA-like domain gene gene454 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00455 S101447_00456 S101447_00456 cysK cysK 486102 487088 - Cysteine synthase Amino-acid biosynthesis%3B CBS domain%3B Cysteine biosynthesis%3B Lyase%3B Phosphoprotein%3B Pyridoxal phosphate%3B Belongs to the cysteine synthase/cystathionine beta- synthase family%3B Contains 1 CBS domain%3B KEGG: apt:APA01_07480 cysteine synthase A gene gene455 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00456 S101447_00457 S101447_00457 S101447_00457 487243 487692 + Putative HTH-type transcriptional regulator DNA-binding%3B Contains 1 HTH rrf2-type DNA-binding domain gene gene456 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00457 S101447_00458 S101447_00458 S101447_00458 487816 488343 - hypothetical protein gene gene457 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00458 S101447_00459 S101447_00459 S101447_00459 488732 489256 + hypothetical protein gene gene458 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00459 S101447_00460 S101447_00460 parE parE 489362 491401 + DNA gyrase subunit B%2C novobiocin-sensitive Antibiotic resistance%3B ATP-binding%3B Cytoplasm%3B DNA-binding%3B Isomerase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Topoisomerase%3B DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings%3B Belongs to the type II topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: apt:APA01_07440 topoisomerase IV subunit B%3B Other isomerases gene gene459 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00460 S101447_00461 S101447_00461 S101447_00461 491471 492397 + Threonine/homoserine exporter RhtA Amino-acid transport%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the efflux of threonine and homoserine%3B Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2. A. 7. 3) family%3B Contains 2 EamA domains gene gene460 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00461 S101447_00462 S101447_00462 nuoM nuoM 492422 493939 - NADH:ubiquinone reductase (H(+)-translocating) Electron transport%3B Membrane%3B Mitochondrion%3B NAD%3B Oxidoreductase%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone%3B Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)%3B Belongs to the complex I subunit 4 family%3B KEGG: gxy:GLX_12600 NADH-quinone oxidoreductase subunit M gene gene461 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00462 S101447_00463 S101447_00463 S101447_00463 494058 495998 - DNA mismatch repair protein MutL DNA damage%3B DNA repair%3B This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker'%2C a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex%3B Belongs to the DNA mismatch repair MutL/HexB family gene gene462 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00463 S101447_00464 S101447_00464 S101447_00464 496016 496546 - hypothetical protein gene gene463 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00464 S101447_00465 S101447_00465 lspA lspA 496594 497109 - Signal peptidase II Aspartyl protease%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Protease%3B Transmembrane%3B Transmembrane helix%3B This protein specifically catalyzes the removal of signal peptides from prolipoproteins%3B Belongs to the peptidase A8 family%3B KEGG: apt:APA01_07390 signal peptidase II gene gene464 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00465 S101447_00466 S101447_00466 iarS iarS 497106 500021 - Isoleucine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B Zinc%3B Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine%2C to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)%3B Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily%3B KEGG: apt:APA01_07380 isoleucyl-tRNA synthetase gene gene465 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00466 S101447_00467 S101447_00467 ribF ribF 500194 501141 - Riboflavin kinase ATP-binding%3B FAD%3B Flavoprotein%3B FMN%3B Kinase%3B Multifunctional enzyme%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase%3B Belongs to the RibF family%3B KEGG: apt:APA01_07370 riboflavin kinase / FMN adenylyltransferase gene gene466 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00467 S101447_00468 S101447_00468 mtnC mtnC 501146 501850 - Acireductone synthase Amino-acid biosynthesis%3B Cytoplasm%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Methionine biosynthesis%3B Nucleus%3B Bifunctional enzyme that catalyzes the enolization of 2%2C3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)%2C which is then dephosphorylated to form the acireductone 1%2C2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)%3B Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family%3B KEGG: apt:APA01_07360 enolase-phosphatase E1 gene gene467 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00468 S101447_00469 S101447_00469 mtnD mtnD 501862 502407 - Acireductone dioxygenase (Ni(2+)-requiring) Amino-acid biosynthesis%3B Dioxygenase%3B Iron%3B Metal-binding%3B Methionine biosynthesis%3B Nickel%3B Oxidoreductase%3B Catalyzes 2 different reactions between oxygene and the acireductone 1%2C2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB)%2C the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate%2C carbon monoxide and formate%2C and does not lie on the methionine recycle pathway%3B Belongs to the acireductone dioxygenase (ARD) family%3B KEGG: acx:Achr_22760 1%2C2-dihydroxy-3-keto-5-methylthiopentene dioxygenase gene gene468 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00469 S101447_00470 S101447_00470 mtnB mtnB 502404 503027 - Methylthioribulose 1-phosphate dehydratase Amino-acid biosynthesis%3B Lyase%3B Metal-binding%3B Methionine biosynthesis%3B Zinc%3B Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2%2C3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)%3B Belongs to the aldolase class II family. MtnB subfamily%3B KEGG: apt:APA01_07340 methylthioribulose-1-phosphate dehydratase gene gene469 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00470 S101447_00471 S101447_00471 S101447_00471 503061 503318 - Sec-independent protein translocase protein TatA Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Translocation%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system%3B Belongs to the TatA/E family gene gene470 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00471 S101447_00472 S101447_00472 S101447_00472 503447 503905 - hypothetical protein gene gene471 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00472 S101447_00473 S101447_00473 S101447_00473 503902 504564 - hypothetical protein gene gene472 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00473 S101447_00474 S101447_00474 argD argD 504764 506011 + Acetylornithine transaminase Amino-acid biosynthesis%3B Aminotransferase%3B Arginine biosynthesis%3B Cytoplasm%3B Pyridoxal phosphate%3B Transferase%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily%3B KEGG: apt:APA01_07300 acetylornithine/N-succinyldiaminopimelate aminotransferase gene gene473 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00474 S101447_00475 S101447_00475 argF argF 506023 507009 + Ornithine carbamoyltransferase Arginine metabolism%3B Cytoplasm%3B Transferase%3B Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline%3B Belongs to the ATCase/OTCase family%3B KEGG: apt:APA01_07290 ornithine carbamoyltransferase gene gene474 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00475 S101447_00476 S101447_00476 S101447_00476 507014 507331 + hypothetical protein gene gene475 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00476 S101447_00477 S101447_00477 S101447_00477 507455 508405 + 33 kDa chaperonin Chaperone%3B Cytoplasm%3B Disulfide bond%3B Redox-active center%3B Stress response%3B Zinc%3B Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress%3B Belongs to the HSP33 family gene gene476 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00477 S101447_00478 S101447_00478 S101447_00478 508541 509485 + hypothetical protein gene gene477 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00478 S101447_00479 S101447_00479 hrpB hrpB 509585 512152 + RNA helicase ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Belongs to the DEAD box helicase family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: apt:APA01_07250 ATP-dependent helicase HrpB gene gene478 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00479 S101447_00480 S101447_00480 degP degP 512291 513409 + Peptidase Do Hydrolase%3B Periplasm%3B Protease%3B Signal%3B A putative protease%2C its function overlaps that of the related putative proteases HhoB and HtrA%3B Belongs to the peptidase S1C family%3B Contains 1 PDZ (DHR) domain%3B KEGG: gxl:H845_2517 serine protease Do gene gene479 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00480 S101447_00481 S101447_00481 akr1 akr1 513426 514280 - Aldehyde reductase KEGG: reh:H16_A3186 aldehyde reductase gene gene480 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00481 S101447_00482 S101447_00482 holC holC 514387 514833 + DNA-directed DNA polymerase KEGG: gbe:GbCGDNIH1_2203 DNA polymerase III subunit chi gene gene481 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00482 S101447_00483 S101447_00483 carP carP 514895 516379 - Leucyl aminopeptidase Aminopeptidase%3B Cytoplasm%3B Hydrolase%3B Manganese%3B Metal-binding%3B Protease%3B Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides%3B Belongs to the peptidase M17 family%3B KEGG: apt:APA01_07210 leucyl aminopeptidase gene gene482 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00483 S101447_00484 S101447_00484 cysQ cysQ 516487 517293 + 3'(2')%2C5'-bisphosphate nucleotidase Cell inner membrane%3B Cell membrane%3B Cytoplasm%3B Hydrolase%3B Magnesium%3B Membrane%3B Metal-binding%3B Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) (By similarity)%3B Belongs to the inositol monophosphatase family%3B KEGG: apt:APA01_07200 3'(2')%2C 5'-bisphosphate nucleotidase gene gene483 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00484 S101447_00485 S101447_00485 tsaC tsaC 517383 518399 + L-threonylcarbamoyladenylate synthase ATP-binding%3B Cytoplasm%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase%3B tRNA processing%3B Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity). Probably catalyzes the conversion of L-threonine%2C HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate%2C with the release of diphosphate. Shows ATP hydrolysis activity in vitro%2C producing AMP%3B Belongs to the SUA5 family%3B Contains 1 YrdC-like domain%3B KEGG: apt:APA01_07190 L-threonylcarbamoyladenylate synthase gene gene484 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00485 S101447_00486 S101447_00486 S101447_00486 518386 518949 + hypothetical protein gene gene485 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00486 S101447_00487 S101447_00487 glcD glcD 518998 520434 + (S)-2-hydroxy-acid oxidase FAD%3B Flavoprotein%3B Mitochondrion%3B Oxidoreductase%3B Transit peptide%3B Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate. May be involved in the catabolism of propionyl-CoA derived from beta-oxidation. Involved in degradation of lysine for the supply of carbon and electrons to the ETF/ETFQO complex during dark-induced sugar starvation%3B Belongs to the FAD-binding oxidoreductase/transferase type 4 family%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: ppk:U875_03890 glycolate oxidase gene gene486 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00487 S101447_00488 S101447_00488 S101447_00488 520523 520990 - hypothetical protein gene gene487 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00488 S101447_00489 S101447_00489 S101447_00489 521024 521680 - hypothetical protein gene gene488 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00489 S101447_00490 S101447_00490 mmaB mmaB 521956 522522 - Cob(I)yrinic acid a%2Cc-diamide adenosyltransferase ATP-binding%3B Cobalamin biosynthesis%3B Cytoplasm%3B Nucleotide-binding%3B Porphyrin biosynthesis%3B Transferase%3B Belongs to the Cob(I)alamin adenosyltransferase family%3B KEGG: pmy:Pmen_0935 cob(I)alamin adenosyltransferase gene gene489 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00490 S101447_00491 S101447_00491 S101447_00491 522593 523051 + hypothetical protein gene gene490 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00491 S101447_00492 S101447_00492 rlmM rlmM 523048 524022 + 23S rRNA (cytidine(2498)-2'-O)-methyltransferase Cytoplasm%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily%3B KEGG: apt:APA01_07120 23S rRNA (cytidine2498-2'-O)-methyltransferase gene gene491 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00492 S101447_00493 S101447_00493 S101447_00493 524081 524368 - hypothetical protein gene gene492 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00493 S101447_00494 S101447_00494 S101447_00494 524378 524992 - hypothetical protein gene gene493 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00494 S101447_00495 S101447_00495 S101447_00495 525050 525313 + hypothetical protein gene gene494 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00495 S101447_00496 S101447_00496 acsS acsS 525351 527273 - Acetate--CoA ligase Acetylation%3B ATP-binding%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Catalyzes the conversion of acetate into acetyl-CoA (AcCoA)%2C an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction%2C AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction%2C it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA%2C forming the product AcCoA%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: apt:APA01_07080 acetyl-CoA synthetase gene gene495 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00496 S101447_00497 S101447_00497 S101447_00497 527490 527924 - hypothetical protein gene gene496 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00497 S101447_00498 S101447_00498 S101447_00498 528466 529179 + putative HTH-type transcriptional regulator DNA-binding%3B Transcription%3B Transcription regulation%3B Contains 1 HTH gntR-type DNA-binding domain gene gene497 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00498 S101447_00499 S101447_00499 putA putA 529379 533014 + Proline dehydrogenase DNA-binding%3B FAD%3B Flavoprotein%3B Multifunctional enzyme%3B NAD%3B Oxidoreductase%3B Proline metabolism%3B Repressor%3B Transcription%3B Transcription regulation%3B Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon%3B In the N-terminal sectio%3B belongs to the proline dehydrogenase family%3B In the C-terminal sectio%3B belongs to the aldehyde dehydrogenase family%3B KEGG: apt:APA01_07050 RHH-type transcriptional regulator%2C proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase gene gene498 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00499 S101447_00500 S101447_00500 S101447_00500 533220 533903 + hypothetical protein gene gene499 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00500 S101447_00501 S101447_00501 S101447_00501 533933 535303 - putative GABA permease Amino-acid transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the degradation of beta-alanine%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2. A. 3. 1) family gene gene500 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00501 S101447_00502 S101447_00502 S101447_00502 535373 536968 - hypothetical protein gene gene501 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00502 S101447_00503 S101447_00503 S101447_00503 537724 537996 - hypothetical protein gene gene502 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00503 S101447_00504 S101447_00504 S101447_00504 538338 538411 - tRNA-Gly tRNA gene503 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00504 S101447_00505 S101447_00505 S101447_00505 538466 539857 - DNA repair protein RadA ATP-binding%3B DNA damage%3B DNA repair%3B DNA-binding%3B Metal-binding%3B Nucleotide-binding%3B Zinc%3B Zinc-finger%3B May play a role in the repair of endogenous alkylation damage. Belongs to the RecA family. RadA subfamily gene gene504 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00505 S101447_00506 S101447_00506 S101447_00506 539941 540972 - hypothetical protein gene gene505 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00506 S101447_00507 S101447_00507 S101447_00507 541179 541964 + putative ABC transporter permease protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Could be part of an ABC transporter complex%3B Belongs to the MlaE permease family gene gene506 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00507 S101447_00508 S101447_00508 S101447_00508 541973 542749 + Spermidine/putrescine import ATP-binding protein PotA ATP-binding%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene507 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00508 S101447_00509 S101447_00509 S101447_00509 542838 542987 + hypothetical protein gene gene508 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00509 S101447_00510 S101447_00510 S101447_00510 543217 545634 + Miniconductance mechanosensitive channel MscM Cell inner membrane%3B Cell membrane%3B Ion channel%3B Ion transport%3B Membrane%3B Signal%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Gates spontaneously in response to increased membrane tension%3B Belongs to the MscS (TC 1. A. 23) family gene gene509 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00510 S101447_00511 S101447_00511 S101447_00511 545698 546486 - hypothetical protein gene gene510 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00511 S101447_00512 S101447_00512 dnaB dnaB 546665 548167 - DNA helicase ATP-binding%3B Autocatalytic cleavage%3B DNA replication%3B DNA-binding%3B Endonuclease%3B Helicase%3B Hydrolase%3B Intron homing%3B Nuclease%3B Nucleotide-binding%3B Primosome%3B Protein splicing%3B Repeat%3B Participates in initiation and elongation during chromosome replicatio%3B it exhibits DNA-dependent ATPase activity%3B The intein is an endonuclease%3B Belongs to the helicase family. DnaB subfamily%3B Contains 1 DOD-type homing endonuclease domain%3B Contains 1 SF4 helicase domain%3B KEGG: apt:APA01_06910 replicative DNA helicase gene gene511 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00512 S101447_00513 S101447_00513 manA manA 548240 549424 - Mannose-6-phosphate isomerase Isomerase%3B Belongs to the N-acylglucosamine 2-epimerase family%3B KEGG: apt:APA01_06900 mannose-6-phosphate isomerase gene gene512 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00513 S101447_00514 S101447_00514 gmhC gmhC 549421 550854 - D-glycero-beta-D-manno-heptose-7-phosphate kinase ATP-binding%3B Carbohydrate metabolism%3B Kinase%3B Multifunctional enzyme%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase%3B Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1%2C7-bisphosphate%3B Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate%2C yielding ADP-D-glycero-beta-D-manno- heptose%3B In the N-terminal sectio%3B belongs to the carbohydrate kinase PfkB family%3B In the C-terminal sectio%3B belongs to the cytidylyltransferase family%3B KEGG: apt:APA01_06890 D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase gene gene513 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00514 S101447_00515 S101447_00515 S101447_00515 550860 551513 - Guanylate kinase ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Essential for recycling GMP and indirectly%2C cGMP%3B Belongs to the guanylate kinase family%3B Contains 1 guanylate kinase-like domain%3B KEGG: apt:APA01_06880 guanylate kinase gene gene514 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00515 S101447_00516 S101447_00516 idnO idnO 551613 552431 + Gluconate 5-dehydrogenase Acetylation%3B Alternative splicing%3B NAD%3B Oxidoreductase%3B Phosphoprotein%3B Secreted%3B Signal%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: rsl:RPSI07_mp0631 gluconate 5-dehydrogenase gene gene515 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00516 S101447_00517 S101447_00517 S101447_00517 552504 553856 + Putative purine-cytosine permease YxlA Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the purine-cytosine permease (2. A. 39) family gene gene516 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00517 S101447_00518 S101447_00518 rlmB rlmB 553790 554632 - 23S rRNA (guanosine(2251)-2'-O)-methyltransferase Cytoplasm%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Specifically methylates the ribose of guanosine 2251 in 23S rRNA%3B Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily%3B KEGG: apt:APA01_06850 23S rRNA (guanosine2251-2'-O)-methyltransferase gene gene517 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00518 S101447_00519 S101447_00519 S101447_00519 554837 555490 + Ribonuclease D DNA damage%3B DNA repair%3B DNA replication%3B DNA-binding%3B DNA-directed DNA polymerase%3B Nucleotidyltransferase%3B Transferase%3B Belongs to the DNA polymerase type-A family%3B Contains 1 3'-5' exonuclease domain%3B KEGG: apt:APA01_06840 ribonuclease D gene gene518 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00519 S101447_00520 S101447_00520 kdsD kdsD 555537 556550 + Arabinose-5-phosphate isomerase CBS domain%3B Isomerase%3B Repeat%3B Belongs to the SIS family. GutQ/KpsF subfamily%3B Contains 2 CBS domains%3B Contains 1 SIS domain%3B KEGG: apt:APA01_06830 arabinose-5-phosphate isomerase gene gene519 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00520 S101447_00521 S101447_00521 S101447_00521 556547 557284 + hypothetical protein gene gene520 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00521 S101447_00522 S101447_00522 S101447_00522 557286 558392 + hypothetical protein gene gene521 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00522 S101447_00523 S101447_00523 lptB lptB 558395 559216 + Lipopolysaccharide export system ATP-binding protein LptB ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Cytoplasm%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1. B. 42) family%3B Contains 1 ABC transporter domain%3B KEGG: apt:APA01_06800 lipopolysaccharide export system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene522 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00523 S101447_00524 S101447_00524 S101447_00524 559213 560061 - uncharacterized protein Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 MOSC domain gene gene523 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00524 S101447_00525 S101447_00525 S101447_00525 560096 560398 - hypothetical protein gene gene524 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00525 S101447_00526 S101447_00526 S101447_00526 560746 561366 + uncharacterized protein Belongs to the ribosomal protein S30Ae family gene gene525 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00526 S101447_00527 S101447_00527 S101447_00527 561456 561722 - hypothetical protein gene gene526 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00527 S101447_00528 S101447_00528 S101447_00528 561741 562250 - Small heat shock protein HspB Stress response%3B Belongs to the small heat shock protein (HSP20) family gene gene527 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00528 S101447_00529 S101447_00529 S101447_00529 562396 563049 + Peptide deformylase Hydrolase%3B Iron%3B Metal-binding%3B Protein biosynthesis%3B Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions%3B Belongs to the polypeptide deformylase family%3B KEGG: apk:APA386B_2176 peptide deformylase gene gene528 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00529 S101447_00530 S101447_00530 S101447_00530 563069 564007 + Methionyl-tRNA formyltransferase Protein biosynthesis%3B Transferase%3B Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP%3B Belongs to the Fmt family%3B KEGG: eco:b3288 methionyl-tRNA formyltransferase gene gene529 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00530 S101447_00531 S101447_00531 truA truA 564004 564792 + tRNA pseudouridine(38-40) synthase Isomerase%3B tRNA processing%3B Formation of pseudouridine at positions 38%2C 39 and 40 in the anticodon stem and loop of transfer RNAs%3B Belongs to the tRNA pseudouridine synthase TruA family%3B KEGG: apt:APA01_06720 tRNA pseudouridine38-40 synthase gene gene530 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00531 S101447_00532 S101447_00532 S101447_00532 564817 565440 - hypothetical protein gene gene531 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00532 S101447_00533 S101447_00533 dapE dapE 565437 566612 - Succinyl-diaminopimelate desuccinylase Amino-acid biosynthesis%3B Cobalt%3B Diaminopimelate biosynthesis%3B Hydrolase%3B Lysine biosynthesis%3B Metal-binding%3B Zinc%3B Catalyzes the hydrolysis of N-succinyl-L%2CL- diaminopimelic acid (SDAP)%2C forming succinate and LL-2%2C6- diaminoheptanedioate (DAP)%2C an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid%2C an essential component of bacterial cell walls%3B Belongs to the peptidase M20A family. DapE subfamily%3B KEGG: apt:APA01_06700 succinyl-diaminopimelate desuccinylase gene gene532 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00533 S101447_00534 S101447_00534 dapD dapD 566650 567498 - 2%2C3%2C4%2C5-tetrahydropyridine-2%2C6-dicarboxylate N-succinyltransferase Acyltransferase%3B Amino-acid biosynthesis%3B Cytoplasm%3B Diaminopimelate biosynthesis%3B Lysine biosynthesis%3B Repeat%3B Transferase%3B Belongs to the transferase hexapeptide repeat family%3B KEGG: apt:APA01_06690 2%2C3%2C4%2C5-tetrahydropyridine-2-carboxylate N-succinyltransferase gene gene533 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00534 S101447_00535 S101447_00535 argB argB 567634 568551 - Acetylglutamate kinase Amino-acid biosynthesis%3B Arginine biosynthesis%3B ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Belongs to the acetylglutamate kinase family%3B KEGG: apt:APA01_06680 acetylglutamate kinase gene gene534 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00535 S101447_00536 S101447_00536 S101447_00536 568583 569266 - putative GTP-binding protein EngB Cell cycle%3B Cell division%3B GTP-binding%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Septation%3B Necessary for normal cell division and for the maintenance of normal septation%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngB GTPase family%3B Contains 1 EngB-type G (guanine nucleotide-binding) domain gene gene535 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00536 S101447_00537 S101447_00537 S101447_00537 569263 571014 - Membrane protein insertase YidC Cell inner membrane%3B Cell membrane%3B Chaperone%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex%2C as well as at least some lipoproteins. Aids folding of multispanning membrane proteins%3B Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily gene gene536 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00537 S101447_00538 S101447_00538 rnpA rnpA 571137 571517 - Ribonuclease P Endonuclease%3B Hydrolase%3B Nuclease%3B RNA-binding%3B tRNA processing%3B RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4. 5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme%3B Belongs to the RnpA family%3B KEGG: apt:APA01_06650 ribonuclease P protein component gene gene537 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00538 S101447_00539 S101447_00539 S101447_00539 571541 571675 - 50S ribosomal protein L34 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein L34P family gene gene538 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00539 S101447_00540 S101447_00540 S101447_00540 571839 572222 + hypothetical protein gene gene539 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00540 S101447_00541 S101447_00541 glo1 glo1 572230 572622 - Lactoylglutathione lyase Lyase%3B Metal-binding%3B Repeat%3B Zinc%3B Catalyzes the conversion of hemimercaptal%2C formed from methylglyoxal and glutathione%2C to S-lactoylglutathione%3B Belongs to the glyoxalase I family%3B KEGG: gox:GOX1824 lactoylglutathione lyase gene gene540 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00541 S101447_00542 S101447_00542 S101447_00542 572647 573504 - hypothetical protein gene gene541 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00542 S101447_00543 S101447_00543 lpxA lpxA 573501 574358 - Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase Acyltransferase%3B Cytoplasm%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Repeat%3B Transferase%3B Involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the transferase hexapeptide repeat family. LpxA subfamily%3B KEGG: apt:APA01_06600 UDP-N-acetylglucosamine acyltransferase gene gene542 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00543 S101447_00544 S101447_00544 fabZ fabZ 574492 575001 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Cytoplasm%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Lyase%3B Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs%3B Belongs to the thioester dehydratase family. FabZ subfamily%3B KEGG: apk:APA386B_2160 3-hydroxyacyl-(acyl-carrier-protein) dehydratase gene gene543 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00544 S101447_00545 S101447_00545 lpxD lpxD 575016 576101 - UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase Acyltransferase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Repeat%3B Transferase%3B Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the transferase hexapeptide repeat family. LpxD subfamily%3B KEGG: apt:APA01_06580 UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase gene gene544 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00545 S101447_00546 S101447_00546 S101447_00546 576104 576973 - hypothetical protein gene gene545 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00546 S101447_00547 S101447_00547 S101447_00547 576981 579485 - Outer membrane protein assembly factor BamA Cell outer membrane%3B Membrane%3B Repeat%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Part of the outer membrane protein assembly complex%2C which is involved in assembly and insertion of beta-barrel proteins into the outer membrane%3B Belongs to the BamA family%3B Contains 5 POTRA domains gene gene546 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00547 S101447_00548 S101447_00548 rseP rseP 579571 580680 - Putative zinc metalloprotease Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Metal-binding%3B Metalloprotease%3B Protease%3B Transmembrane%3B Transmembrane helix%3B Zinc%3B Belongs to the peptidase M50B family%3B Contains 1 PDZ (DHR) domain%3B KEGG: apt:APA01_06550 regulator of sigma E protease%3B Metalloendopeptidases gene gene547 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00548 S101447_00549 S101447_00549 S101447_00549 580715 581872 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase Isoprene biosynthesis%3B Metal-binding%3B NADP%3B Oxidoreductase%3B Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)%3B Belongs to the DXR family%3B KEGG: serr:Ser39006_1608 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene gene548 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00549 S101447_00550 S101447_00550 cds1 cds1 581949 582785 - Phosphatidate cytidylyltransferase Cell inner membrane%3B Cell membrane%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Nucleotidyltransferase%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Belongs to the CDS family%3B KEGG: apt:APA01_06530 phosphatidate cytidylyltransferase gene gene549 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00550 S101447_00551 S101447_00551 uppS uppS 582782 583522 - Ditrans%2Cpolycis-undecaprenyl-diphosphate synthase ((2E%2C6E)-farnesyl-diphosphate specific) Magnesium%3B Metal-binding%3B Transferase%3B Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z%2C6Z%2C10Z%2C14Z%2C18Z%2C22Z%2C26Z%2C30E%2C34E%2C38E)-undecaprenyl diphosphate (tritrans%2Cheptacis-UPP). It is probably the precursor of glycosyl carrier lipids%3B Belongs to the UPP synthase family%3B KEGG: apt:APA01_06520 undecaprenyl diphosphate synthase gene gene550 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00551 S101447_00552 S101447_00552 S101447_00552 583585 584148 - Ribosome-recycling factor Cytoplasm%3B Protein biosynthesis%3B Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another%3B Belongs to the RRF family gene gene551 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00552 S101447_00553 S101447_00553 pyrH pyrH 584255 584992 - UMP kinase ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Pyrimidine biosynthesis%3B Transferase%3B Catalyzes the reversible phosphorylation of UMP to UDP%3B Belongs to the UMP kinase family%3B KEGG: apt:APA01_06500 uridylate kinase gene gene552 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00553 S101447_00554 S101447_00554 S101447_00554 585106 586008 - GTPase Era Cell inner membrane%3B Cell membrane%3B Cytoplasm%3B GTP-binding%3B Membrane%3B Nucleotide-binding%3B Ribosome biogenesis%3B RNA-binding%3B rRNA-binding%3B An essential GTPase that binds both GDP and GTP%2C with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Era GTPase family%3B Contains 1 Era-type G (guanine nucleotide-binding) domain%3B Contains 1 KH type-2 domain gene gene553 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00554 S101447_00555 S101447_00555 rnt1 rnt1 586015 586749 - Ribonuclease III Cytoplasm%3B Endonuclease%3B Hydrolase%3B Magnesium%3B Metal-binding%3B mRNA processing%3B Nuclease%3B RNA-binding%3B rRNA processing%3B rRNA-binding%3B tRNA processing%3B Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs%2C and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism%3B Contains 1 DRBM (double-stranded RNA-binding) domain%3B Contains 1 RNase III domain%3B KEGG: apk:APA386B_2149 ribonuclease III gene gene554 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00555 S101447_00556 S101447_00556 lepB lepB 586746 587552 - Signal peptidase I Cell membrane%3B Hydrolase%3B Membrane%3B Protease%3B Transmembrane%3B Transmembrane helix%3B Belongs to the peptidase S26 family%3B KEGG: apt:APA01_06470 signal peptidase I gene gene555 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00556 S101447_00557 S101447_00557 acpS acpS 587641 588048 - Holo-[acyl-carrier-protein] synthase Cytoplasm%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Magnesium%3B Metal-binding%3B Transferase%3B Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein%3B Belongs to the P-Pant transferase superfamily. AcpS family%3B KEGG: apt:APA01_06460 holo-(acyl-carrier protein) synthase gene gene556 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00557 S101447_00558 S101447_00558 relA relA 588045 590348 - GTP diphosphokinase ATP-binding%3B GTP-binding%3B Kinase%3B Nucleotide-binding%3B Transferase%3B In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. It also has (p)ppGpp-degrading activities. Belongs to the RelA/SpoT family%3B Contains 1 ACT domain%3B Contains 1 HD domain%3B KEGG: apt:APA01_06450 GTP pyrophosphokinase gene gene557 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00558 S101447_00559 S101447_00559 rpoZ rpoZ 590423 590794 - DNA-directed RNA polymerase DNA-directed RNA polymerase%3B Nucleotidyltransferase%3B Transcription%3B Transferase%3B Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits%3B Belongs to the RNA polymerase subunit omega family%3B KEGG: hik:HifGL_001422 DNA-directed RNA polymerase subunit omega gene gene558 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00559 S101447_00560 S101447_00560 folK folK 590885 591397 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase ATP-binding%3B Folate biosynthesis%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Belongs to the HPPK family%3B KEGG: apt:APA01_06430 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase gene gene559 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00560 S101447_00561 S101447_00561 S101447_00561 591555 592178 + hypothetical protein gene gene560 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00561 S101447_00562 S101447_00562 cynT cynT 592340 593026 + Carbonate dehydratase Lyase%3B Metal-binding%3B Zinc%3B Belongs to the beta-class carbonic anhydrase family%3B KEGG: bid:Bind_0612 carbonic anhydrase gene gene561 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00562 S101447_00563 S101447_00563 S101447_00563 593250 593924 + hypothetical protein gene gene562 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00563 S101447_00564 S101447_00564 rhlE rhlE 594000 595337 - RNA helicase ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Nucleus%3B Ribosome biogenesis%3B RNA-binding%3B rRNA processing%3B ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0%2C A1 and A2 sites. Required for vegetative growth (By similarity)%3B Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: apt:APA01_06390 ATP-dependent RNA helicase RhlE gene gene563 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00564 S101447_00565 S101447_00565 metX metX 595794 596399 - Homoserine O-acetyltransferase KEGG: tas:TASI_1417 homoserine O-acetyltransferase%3B overlaps another CDS with the same product name gene gene564 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00565 S101447_00566 S101447_00566 S101447_00566 596399 597574 - Homoserine O-acetyltransferase Acyltransferase%3B Amino-acid biosynthesis%3B Cytoplasm%3B Methionine biosynthesis%3B Transferase%3B Involved in the methionine biosynthesis. Catalyzes the transfer of the acetyl group from acetyl-CoA to the hydroxyl group of L-homoserine to yield O-acetyl-L-homoserine%3B Belongs to the AB hydrolase superfamily. HTA family%3B KEGG: apt:APA01_06370 homoserine O-acetyltransferase%3B overlaps another CDS with the same product name gene gene565 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00566 S101447_00567 S101447_00567 S101447_00567 597701 599506 - Elongation factor Cell inner membrane%3B Cell membrane%3B GTP-binding%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Protein biosynthesis%3B Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction%2C by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex%2C thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene566 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00567 S101447_00568 S101447_00568 S101447_00568 599632 600276 - hypothetical protein gene gene567 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00568 S101447_00569 S101447_00569 S101447_00569 600273 600554 - hypothetical protein gene gene568 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00569 S101447_00570 S101447_00570 S101447_00570 600636 603050 - Quinoprotein glucose dehydrogenase (PQQ%2C quinone) Cell inner membrane%3B Cell membrane%3B Membrane%3B Oxidoreductase%3B PQQ%3B Signal%3B Transmembrane%3B Transmembrane helix%3B Belongs to the bacterial PQQ dehydrogenase family%3B KEGG: apt:APA01_06330 quinoprotein glucose dehydrogenase gene gene569 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00570 S101447_00571 S101447_00571 S101447_00571 603255 604355 - hypothetical protein gene gene570 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00571 S101447_00572 S101447_00572 glnA glnA 604439 605884 - Glutamate--ammonia ligase ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Phosphoprotein%3B Belongs to the glutamine synthetase family%3B KEGG: apt:APA01_06310 glutamine synthetase gene gene571 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00572 S101447_00573 S101447_00573 S101447_00573 605990 606328 - Nitrogen regulatory protein P-II Nucleotide-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B In nitrogen-limiting conditions%2C when the ratio of Gln to 2-ketoglutarate decreases%2C P-II is uridylylated to P-II-UMP. P- II-UMP allows the deadenylation of glutamine synthetase (GS)%2C thus activating the enzyme. Conversely%2C in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate%2C the transcriptional activator of glnA. When P-II is uridylylated to P- II-UMP%2C these events are reversed (By similarity)%3B Belongs to the P(II) protein family gene gene572 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00573 S101447_00574 S101447_00574 dapC dapC 606568 607743 + Succinyldiaminopimelate transaminase Aminotransferase%3B Cytoplasm%3B Pyridoxal phosphate%3B Transferase%3B Shows aminotransferase activity with methionine and histidine as substrates%2C and to a lesser extent also with phenylalanine%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: crd:CRES_0728 N-succinyldiaminopimelate aminotransferase gene gene573 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00574 S101447_00575 S101447_00575 S101447_00575 607816 607891 + tRNA-His tRNA gene574 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00575 S101447_00576 S101447_00576 S101447_00576 608159 610276 - hypothetical protein gene gene575 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00576 S101447_00577 S101447_00577 idh1 idh1 610661 611881 + Isocitrate dehydrogenase (NADP(+)) Glyoxylate bypass%3B Magnesium%3B Manganese%3B Metal-binding%3B Mitochondrion%3B NADP%3B Oxidoreductase%3B Transit peptide%3B Tricarboxylic acid cycle%3B Belongs to the isocitrate and isopropylmalate dehydrogenases family%3B KEGG: rpa:RPA3834 isocitrate dehydrogenase gene gene576 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00577 S101447_00578 S101447_00578 trxB trxB 612046 613062 + Thioredoxin-disulfide reductase FAD%3B Flavoprotein%3B NADP%3B Oxidoreductase%3B Belongs to the ferredoxin--NADP reductase type 2 family%3B KEGG: apt:APA01_06240 thioredoxin reductase (NADPH) gene gene577 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00578 S101447_00579 S101447_00579 dadA dadA 613260 614516 + D-arginine dehydrogenase FAD%3B Flavoprotein%3B Oxidoreductase%3B Oxidative deamination of D-amino acids%3B Belongs to the DadA oxidoreductase family%3B KEGG: dda:Dd703_1813 D-amino-acid dehydrogenase gene gene578 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00579 S101447_00580 S101447_00580 S101447_00580 614774 615082 - hypothetical protein gene gene579 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00580 S101447_00581 S101447_00581 S101447_00581 615441 617258 - Elongation factor Cytoplasm%3B Elongation factor%3B GTP-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step%2C the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites%2C respectively. Catalyzes the coordinated movement of the two tRNA molecules%2C the mRNA and conformational changes in the ribosome (By similarity)%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene580 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00581 S101447_00582 S101447_00582 S101447_00582 617508 617900 + hypothetical protein gene gene581 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00582 S101447_00583 S101447_00583 S101447_00583 617965 619119 + putative MFS-type transporter YfkF Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the major facilitator superfamily gene gene582 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00583 S101447_00584 S101447_00584 S101447_00584 619134 620348 - Gluconolactonase KEGG: apt:APA01_06170 gluconolactonase gene gene583 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00584 S101447_00585 S101447_00585 S101447_00585 620493 621953 - Pyruvate kinase ATP-binding%3B Glycolysis%3B Kinase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Potassium%3B Pyruvate%3B Transferase%3B Belongs to the pyruvate kinase family%3B KEGG: apt:APA01_06160 pyruvate kinase gene gene584 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00585 S101447_00586 S101447_00586 S101447_00586 621986 623002 - hypothetical protein gene gene585 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00586 S101447_00587 S101447_00587 S101447_00587 623282 624094 - Adenylyltransferase and sulfurtransferase MOCS3-1 ATP-binding%3B Cytoplasm%3B Metal-binding%3B Molybdenum cofactor biosynthesis%3B Multifunctional enzyme%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B tRNA processing%3B Zinc%3B Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys)%2C tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP)%2C then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently%2C a transient disulfide bond is formed. Does not use thiosulfate as sulfur dono%3B NFS1 probably acting as a sulfur donor for thiocarboxylation reactions%3B In the N-terminal sectio%3B belongs to the HesA/MoeB/ThiF family. UBA4 subfamily%3B Contains 1 rhodanese domain gene gene586 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00587 S101447_00588 S101447_00588 S101447_00588 624288 624899 + hypothetical protein gene gene587 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00588 S101447_00589 S101447_00589 S101447_00589 625025 625255 - hypothetical protein gene gene588 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00589 S101447_00590 S101447_00590 S101447_00590 625332 625988 + hypothetical protein gene gene589 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00590 S101447_00591 S101447_00591 S101447_00591 626235 628097 + hypothetical protein gene gene590 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00591 S101447_00592 S101447_00592 S101447_00592 628276 630246 + Putative oligopeptide transporter Cell membrane%3B Membrane%3B Peptide transport%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the oligopeptide OPT transporter family gene gene591 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00592 S101447_00593 S101447_00593 S101447_00593 630254 632602 - hypothetical protein gene gene592 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00593 S101447_00594 S101447_00594 S101447_00594 632663 633478 - hypothetical protein gene gene593 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00594 S101447_00595 S101447_00595 ybfF ybfF 633730 634527 + Esterase Hydrolase%3B Serine esterase%3B Displays esterase activity toward palmitoyl-CoA%2C malonyl-CoA and pNP-butyrate%3B Belongs to the DmpD/TodF/XylF esterase family%3B KEGG: enc:ECL_03029 esterase%3B Acting on ester bonds gene gene594 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00595 S101447_00596 S101447_00596 S101447_00596 634559 636217 - uncharacterized protein gene gene595 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00596 S101447_00597 S101447_00597 S101447_00597 636435 637595 + Metal tolerance protein Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Vacuole%3B Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis%3B Belongs to the cation diffusion facilitator (CDF) transporter (TC 2. A. 4) family. SLC30A subfamily gene gene596 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00597 S101447_00598 S101447_00598 S101447_00598 637656 638621 + putative transporter Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the cation diffusion facilitator (CDF) transporter (TC 2. A. 4) family gene gene597 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00598 S101447_00599 S101447_00599 S101447_00599 638745 640139 + H(+)/Cl(-) exchange transporter ClcA Antiport%3B Cell inner membrane%3B Cell membrane%3B Chloride%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation%2C as part of the extreme acid resistance (XAR) response%3B Belongs to the chloride channel (TC 2. A. 49) family. ClcA subfamily gene gene598 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00599 S101447_00600 S101447_00600 S101447_00600 640227 641231 + Protein CobW ATP-binding%3B Cobalamin biosynthesis%3B Nucleotide-binding%3B Porphyrin biosynthesis%3B Might be involved in cobalt reduction leading to cobalt(I) corrinoids. Belongs to the SIMIBI class G3E GTPase family. CobW subfamily%3B Contains 1 cobW C-terminal domain gene gene599 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00600 S101447_00601 S101447_00601 S101447_00601 641228 642283 + hypothetical protein gene gene600 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00601 S101447_00602 S101447_00602 S101447_00602 642418 643701 + NADH dehydrogenase Cell membrane%3B Electron transport%3B FAD%3B Flavoprotein%3B Membrane%3B NAD%3B Oxidoreductase%3B Transport%3B Ubiquinone%3B Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation. Belongs to the NADH dehydrogenase family%3B KEGG: gxy:GLX_02910 NADH dehydrogenase gene gene601 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00602 S101447_00603 S101447_00603 S101447_00603 643954 644130 - hypothetical protein gene gene602 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00603 S101447_00604 S101447_00604 S101447_00604 644172 644657 - 17.1 kDa class II heat shock protein Cytoplasm%3B Stress response%3B Belongs to the small heat shock protein (HSP20) family gene gene603 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00604 S101447_00605 S101447_00605 dlaT dlaT 644929 646095 - Dihydrolipoyllysine-residue acetyltransferase Acetoin catabolism%3B Acyltransferase%3B Lipoyl%3B Transferase%3B Belongs to the 2-oxoacid dehydrogenase family%3B Contains 1 lipoyl-binding domain%3B KEGG: apt:APA01_05960 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) gene gene604 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00605 S101447_00606 S101447_00606 pdhB pdhB 646099 647127 - Pyruvate dehydrogenase (acetyl-transferring) Acetoin catabolism%3B Oxidoreductase%3B Catalyzes the 2%2C6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde%3B KEGG: bph:Bphy_7509 pyruvate dehydrogenase E1 component beta subunit gene gene605 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00606 S101447_00607 S101447_00607 S101447_00607 647175 648146 - Pyruvate dehydrogenase (acetyl-transferring) Acetoin catabolism%3B Oxidoreductase%3B Thiamine pyrophosphate%3B KEGG: apt:APA01_05940 pyruvate dehydrogenase E1 component alpha subunit gene gene606 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00607 S101447_00608 S101447_00608 S101447_00608 648409 648633 + hypothetical protein gene gene607 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00608 S101447_00609 S101447_00609 S101447_00609 648704 650317 + putative low-affinity inorganic phosphate transporter Cell membrane%3B Membrane%3B Phosphate transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Low-affinity inorganic phosphate transport%3B Belongs to the inorganic phosphate transporter (PiT) (TC 2. A. 20) family. Pit subfamily gene gene608 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00609 S101447_00610 S101447_00610 S101447_00610 650374 651291 + Polyphosphate kinase KEGG: ret:RHE_PC00203 polyphosphate kinase gene gene609 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00610 S101447_00611 S101447_00611 S101447_00611 651748 653463 + hypothetical protein gene gene610 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00611 S101447_00612 S101447_00612 S101447_00612 653545 654132 - hypothetical protein gene gene611 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00612 S101447_00613 S101447_00613 S101447_00613 654276 656732 - hypothetical protein gene gene612 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00613 S101447_00614 S101447_00614 pepO pepO 656974 658971 + Endothelin-converting enzyme Cell membrane%3B Disulfide bond%3B Glycoprotein%3B Hydrolase%3B Membrane%3B Metal-binding%3B Metalloprotease%3B Phosphoprotein%3B Protease%3B Signal-anchor%3B Transmembrane%3B Transmembrane helix%3B Zinc%3B Converts big endothelin-1 to endothelin-1. Belongs to the peptidase M13 family%3B KEGG: apt:APA01_05620 putative endopeptidase%3B Metalloendopeptidases gene gene613 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00614 S101447_00615 S101447_00615 S101447_00615 658974 659072 + hypothetical protein gene gene614 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00615 S101447_00616 S101447_00616 S101447_00616 659251 660402 + hypothetical protein gene gene615 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00616 S101447_00617 S101447_00617 S101447_00617 660513 662204 - hypothetical protein gene gene616 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00617 S101447_00618 S101447_00618 yciA yciA 662510 662950 + putative acyl-CoA thioester hydrolase Hydrolase%3B Belongs to the acyl coenzyme A hydrolase family%3B Contains 1 HotDog ACOT-type domain%3B KEGG: apt:APA01_05590 acyl-CoA thioesterase YciA%3B Thiolester hydrolases gene gene617 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00618 S101447_00619 S101447_00619 S101447_00619 663183 664007 + hypothetical protein gene gene618 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00619 S101447_00620 S101447_00620 S101447_00620 664077 664460 + Lactoylglutathione lyase KEGG: zmo:ZMO1721 lactoylglutathione lyase gene gene619 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00620 S101447_00621 S101447_00621 S101447_00621 664587 665021 - Putative fluoride ion transporter CrcB Cell inner membrane%3B Cell membrane%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Important for reducing fluoride concentration in the cell%2C thus reducing its toxicity%3B Belongs to the CrcB (TC 9. B. 71) family gene gene620 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00621 S101447_00622 S101447_00622 ydfG ydfG 665031 665801 - Sulfoacetaldehyde reductase NADP%3B Oxidoreductase%3B Catalyzes the formation of isethionate from 2- sulfoacetaldehyde in the deaminative pathway of taurine. Constitutively expressed enzyme that only mediates a small part of the activity observed in taurine-grown cells%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: apk:APA386B_2052 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase gene gene621 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00622 S101447_00623 S101447_00623 S101447_00623 665946 666455 - Protein aau3 2Fe-2S%3B DNA-binding%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Required for growth utilizing PHB cycle intermediates. Contains 1 HTH rrf2-type DNA-binding domain gene gene622 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00623 S101447_00624 S101447_00624 S101447_00624 666536 666766 + DNA-3-methyladenine glycosylase II To M. tuberculosis Rv3073c%3B KEGG: btp:D805_0940 DNA-3-methyladenine glycosylase gene gene623 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00624 S101447_00625 S101447_00625 S101447_00625 666879 667013 - hypothetical protein gene gene624 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00625 S101447_00626 S101447_00626 purU purU 667336 668181 + Formyltetrahydrofolate deformylase Hydrolase%3B One-carbon metabolism%3B Purine biosynthesis%3B Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)%3B Belongs to the PurU family%3B Contains 1 ACT domain%3B KEGG: apt:APA01_05510 formyltetrahydrofolate deformylase gene gene625 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00626 S101447_00627 S101447_00627 S101447_00627 668297 668617 - Transcription termination factor Rho ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B RNA-binding%3B Transcription%3B Transcription regulation%3B Transcription termination%3B Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA%2C activation of Rho's RNA-dependent ATPase activity%2C and release of the mRNA from the DNA template. Belongs to the Rho family gene gene626 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00627 S101447_00628 S101447_00628 S101447_00628 668868 669428 + hypothetical protein gene gene627 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00628 S101447_00629 S101447_00629 S101447_00629 669548 670111 - hypothetical protein gene gene628 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00629 S101447_00630 S101447_00630 S101447_00630 670111 670992 - hypothetical protein gene gene629 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00630 S101447_00631 S101447_00631 S101447_00631 671460 671795 - hypothetical protein gene gene630 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00631 S101447_00632 S101447_00632 S101447_00632 672206 673111 - hypothetical protein gene gene631 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00632 S101447_00633 S101447_00633 S101447_00633 673132 674703 - hypothetical protein gene gene632 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00633 S101447_00634 S101447_00634 S101447_00634 674710 675972 - Na(+)/H(+) antiporter ApNhaP Antiport%3B Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Sodium%3B Sodium transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Shows also high Ca(2+)/H(+) antiporter activity at alkaline pH. Does not catalyze exchange between Li(+) and H(+)%3B Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2. A. 36) family gene gene633 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00634 S101447_00635 S101447_00635 S101447_00635 676045 676491 - hypothetical protein gene gene634 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00635 S101447_00636 S101447_00636 S101447_00636 676614 677183 - hypothetical protein gene gene635 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00636 S101447_00637 S101447_00637 S101447_00637 677190 678287 - hypothetical protein gene gene636 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00637 S101447_00638 S101447_00638 S101447_00638 678295 678873 - hypothetical protein gene gene637 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00638 S101447_00639 S101447_00639 S101447_00639 678873 680108 - hypothetical protein gene gene638 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00639 S101447_00640 S101447_00640 S101447_00640 680095 680448 - hypothetical protein gene gene639 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00640 S101447_00641 S101447_00641 S101447_00641 680460 680837 - hypothetical protein gene gene640 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00641 S101447_00642 S101447_00642 S101447_00642 680795 681148 - hypothetical protein gene gene641 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00642 S101447_00643 S101447_00643 S101447_00643 681145 682071 - hypothetical protein gene gene642 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00643 S101447_00644 S101447_00644 S101447_00644 682068 682388 - hypothetical protein gene gene643 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00644 S101447_00645 S101447_00645 S101447_00645 682385 683098 - hypothetical protein gene gene644 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00645 S101447_00646 S101447_00646 S101447_00646 683134 683934 - hypothetical protein gene gene645 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00646 S101447_00647 S101447_00647 S101447_00647 683877 684146 - hypothetical protein gene gene646 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00647 S101447_00648 S101447_00648 S101447_00648 684131 684292 - hypothetical protein gene gene647 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00648 S101447_00649 S101447_00649 S101447_00649 684316 684771 - hypothetical protein gene gene648 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00649 S101447_00650 S101447_00650 S101447_00650 684810 685247 - hypothetical protein gene gene649 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00650 S101447_00651 S101447_00651 S101447_00651 685250 686404 - hypothetical protein gene gene650 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00651 S101447_00652 S101447_00652 S101447_00652 686423 686995 - hypothetical protein gene gene651 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00652 S101447_00653 S101447_00653 S101447_00653 686956 687336 - hypothetical protein gene gene652 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00653 S101447_00654 S101447_00654 S101447_00654 687327 687824 - hypothetical protein gene gene653 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00654 S101447_00655 S101447_00655 S101447_00655 687870 688187 - hypothetical protein gene gene654 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00655 S101447_00656 S101447_00656 S101447_00656 688237 689274 - hypothetical protein gene gene655 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00656 S101447_00657 S101447_00657 S101447_00657 689274 689774 - hypothetical protein gene gene656 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00657 S101447_00658 S101447_00658 S101447_00658 689812 690345 - hypothetical protein gene gene657 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00658 S101447_00659 S101447_00659 S101447_00659 690533 690838 - hypothetical protein gene gene658 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00659 S101447_00660 S101447_00660 S101447_00660 690835 692118 - hypothetical protein gene gene659 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00660 S101447_00661 S101447_00661 S101447_00661 692459 693511 + UPF0176 protein Belongs to the UPF0176 family%3B Contains 1 rhodanese domain gene gene660 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00661 S101447_00662 S101447_00662 S101447_00662 693508 694962 - hypothetical protein gene gene661 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00662 S101447_00663 S101447_00663 S101447_00663 694996 695178 - hypothetical protein gene gene662 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00663 S101447_00664 S101447_00664 S101447_00664 695165 695707 - hypothetical protein gene gene663 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00664 S101447_00665 S101447_00665 S101447_00665 695909 696514 + hypothetical protein gene gene664 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00665 S101447_00666 S101447_00666 S101447_00666 696511 698697 - Putative O-acetyltransferase Acyltransferase%3B Cell membrane%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Belongs to the acyltransferase 3 family%3B KEGG: bra:BRADO5159 null%3B Transferring groups other than amino-acyl groups gene gene665 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00666 S101447_00667 S101447_00667 bchR bchR 699128 700471 + putative methyltransferase 4Fe-4S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Belongs to the methyltransferase superfamily%3B Contains 1 B12-binding domain%3B KEGG: pvi:Cvib_1051 bacteriochlorophyll C12 methyltransferase%3B Methyltransferases gene gene666 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00667 S101447_00668 S101447_00668 S101447_00668 701031 702185 + hypothetical protein gene gene667 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00668 S101447_00669 S101447_00669 S101447_00669 702265 702819 - Putative DNA-invertase from lambdoid prophage Qin DNA integration%3B DNA invertase%3B DNA recombination%3B DNA-binding%3B Belongs to the site-specific recombinase resolvase family%3B Contains 1 resolvase/invertase-type recombinase catalytic domain gene gene668 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00669 S101447_00670 S101447_00670 S101447_00670 703139 704896 + hypothetical protein gene gene669 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00670 S101447_00671 S101447_00671 S101447_00671 704993 705532 - hypothetical protein gene gene670 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00671 S101447_00672 S101447_00672 S101447_00672 705576 706223 - hypothetical protein gene gene671 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00672 S101447_00673 S101447_00673 S101447_00673 706224 707063 - hypothetical protein gene gene672 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00673 S101447_00674 S101447_00674 S101447_00674 707063 707590 - hypothetical protein gene gene673 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00674 S101447_00675 S101447_00675 S101447_00675 708274 708681 + hypothetical protein gene gene674 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00675 S101447_00676 S101447_00676 S101447_00676 708898 710895 + hypothetical protein gene gene675 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00676 S101447_00677 S101447_00677 S101447_00677 710938 711156 - hypothetical protein gene gene676 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00677 S101447_00678 S101447_00678 S101447_00678 711267 711920 - Leucine efflux protein Amino-acid transport%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Exporter of leucine%3B Belongs to the rht family gene gene677 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00678 S101447_00679 S101447_00679 S101447_00679 712143 713591 + hypothetical protein gene gene678 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00679 S101447_00680 S101447_00680 S101447_00680 713723 714007 + hypothetical protein gene gene679 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00680 S101447_00681 S101447_00681 S101447_00681 714051 714485 - hypothetical protein gene gene680 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00681 S101447_00682 S101447_00682 S101447_00682 714511 714831 - hypothetical protein gene gene681 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00682 S101447_00683 S101447_00683 S101447_00683 715014 715331 + hypothetical protein gene gene682 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00683 S101447_00684 S101447_00684 S101447_00684 715423 716673 + D-amino-acid oxidase KEGG: aje:HCAG_00881 D-amino-acid oxidase gene gene683 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00684 S101447_00685 S101447_00685 S101447_00685 716678 717169 + hypothetical protein gene gene684 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00685 S101447_00686 S101447_00686 S101447_00686 717291 719507 - Ferrichrysobactin receptor Cell outer membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Involved in the initial step of iron uptake by binding chrysobactin%2C an iron chelatin siderophore that allows the bacteria to extract iron from the environment. Belongs to the TonB-dependent receptor family gene gene685 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00686 S101447_00687 S101447_00687 S101447_00687 719933 720622 - hypothetical protein gene gene686 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00687 S101447_00688 S101447_00688 S101447_00688 720686 721063 - hypothetical protein gene gene687 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00688 S101447_00689 S101447_00689 S101447_00689 721070 721732 - hypothetical protein gene gene688 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00689 S101447_00690 S101447_00690 S101447_00690 721954 723351 - hypothetical protein gene gene689 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00690 S101447_00691 S101447_00691 S101447_00691 723742 724566 + hypothetical protein gene gene690 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00691 S101447_00692 S101447_00692 S101447_00692 724754 725284 + hypothetical protein gene gene691 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00692 S101447_00693 S101447_00693 S101447_00693 725397 725786 - hypothetical protein gene gene692 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00693 S101447_00694 S101447_00694 S101447_00694 725942 726334 - hypothetical protein gene gene693 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00694 S101447_00695 S101447_00695 S101447_00695 726428 727375 - Dihydrolipoyllysine-residue acetyltransferase Alternative splicing%3B Calcium%3B Cytoplasm%3B RNA editing%3B Sensory transduction%3B Vision%3B Plays important roles in both rhabdomere development and in photoreceptor cell survival. Might function as a calcium- sequestering 'sponge' to regulate the amount of free cytoplasmic calcium. It binds 0. 3 mole of Ca(2+) per mole of protein%3B KEGG: ssan:NX02_20525 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) gene gene694 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00695 S101447_00696 S101447_00696 S101447_00696 727619 728068 + hypothetical protein gene gene695 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00696 S101447_00697 S101447_00697 S101447_00697 728337 729140 + hypothetical protein gene gene696 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00697 S101447_00698 S101447_00698 S101447_00698 729206 729394 - hypothetical protein gene gene697 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00698 S101447_00699 S101447_00699 S101447_00699 729562 729837 + hypothetical protein gene gene698 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00699 S101447_00700 S101447_00700 S101447_00700 729939 730337 - hypothetical protein gene gene699 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00700 S101447_00701 S101447_00701 S101447_00701 730391 730753 - uncharacterized protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the YggT family gene gene700 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00701 S101447_00702 S101447_00702 S101447_00702 730823 730898 + tRNA-Ala tRNA gene701 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00702 S101447_00703 S101447_00703 S101447_00703 731354 733069 + hypothetical protein gene gene702 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00703 S101447_00704 S101447_00704 S101447_00704 733185 733550 - hypothetical protein gene gene703 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00704 S101447_00705 S101447_00705 S101447_00705 733763 734134 + hypothetical protein gene gene704 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00705 S101447_00706 S101447_00706 S101447_00706 734450 735721 + hypothetical protein gene gene705 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00706 S101447_00707 S101447_00707 S101447_00707 735802 737481 - hypothetical protein gene gene706 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00707 S101447_00708 S101447_00708 S101447_00708 737885 738112 + hypothetical protein gene gene707 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00708 S101447_00709 S101447_00709 S101447_00709 738127 739224 - 2-polyprenyl-6-hydroxyphenol methylase KEGG: oat:OAN307_c35270 2-polyprenyl-6-hydroxyphenyl methylase / 3-demethylubiquinone-9 3-methyltransferase gene gene708 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00709 S101447_00710 S101447_00710 S101447_00710 739332 739640 + hypothetical protein gene gene709 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00710 S101447_00711 S101447_00711 S101447_00711 739873 740406 + hypothetical protein gene gene710 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00711 S101447_00712 S101447_00712 S101447_00712 740513 740974 + Isoquinoline 1-oxidoreductase 2Fe-2S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase%3B Specific towards N-containing N-heterocyclic substrates%2C including isoquinoline%2C isoquinolin-5-ol%2C phthalazine and quinazoline. Contains 1 2Fe-2S ferredoxin-type domain%3B KEGG: pfn:HZ99_13870 isoquinoline 1-oxidoreductase%2C alpha subunit%3B overlaps another CDS with the same product name gene gene711 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00712 S101447_00713 S101447_00713 S101447_00713 740971 743163 + Isoquinoline 1-oxidoreductase Oxidoreductase%3B KEGG: apt:APA01_04660 isoquinoline 1-oxidoreductase%2C beta subunit%3B overlaps another CDS with the same product name gene gene712 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00713 S101447_00714 S101447_00714 S101447_00714 743168 744472 + Nicotinate dehydrogenase (cytochrome) Cell membrane%3B Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Pyrrolidone carboxylic acid%3B Repeat%3B Signal%3B Transport%3B Dehydration of primary alcohols (exception: methanol). Contains 3 cytochrome c domains%3B KEGG: pfs:PFLU_2803 nicotinate dehydrogenase subunit B gene gene713 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00714 S101447_00715 S101447_00715 aldA aldA 744588 746036 - Lactaldehyde dehydrogenase Acetylation%3B Mitochondrion%3B NAD%3B Oxidoreductase%3B Transit peptide%3B ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids%2C biogenic amines%2C neurotransmitters%2C and lipid peroxidation. In the cornea%2C this enzyme may help in the absorption of the damaging UV-B%2C as well as in the detoxification of the UV-induced peroxidic aldehydes. Belongs to the aldehyde dehydrogenase family%3B KEGG: apt:APA01_04640 lactaldehyde dehydrogenase / glycolaldehyde dehydrogenase gene gene714 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00715 S101447_00716 S101447_00716 S101447_00716 746142 746399 - hypothetical protein gene gene715 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00716 S101447_00717 S101447_00717 S101447_00717 746400 747008 - putative HTH-type transcriptional regulator YneJ DNA-binding%3B Transcription%3B Transcription regulation%3B Contains 1 HTH lysR-type DNA-binding domain gene gene716 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00717 S101447_00718 S101447_00718 dkgA dkgA 747015 747851 - 2%2C5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming) Ascorbate biosynthesis%3B Cytoplasm%3B NADP%3B Oxidoreductase%3B Catalyzes the reduction of 2%2C5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 25DKGR-B has higher catalytic efficiency than 25DKGR-A%3B Belongs to the aldo/keto reductase family%3B KEGG: actn:L083_7354 2%2C5-diketo-D-gluconate reductase A gene gene717 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00718 S101447_00719 S101447_00719 S101447_00719 747996 748748 - hypothetical protein gene gene718 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00719 S101447_00720 S101447_00720 S101447_00720 748876 749466 - Methylamine utilization protein MauD Membrane%3B Transmembrane%3B Transmembrane helix%3B May be specifically involved in the processing%2C transport%2C and/or maturation of the MADH beta-subunit. Contains 1 thioredoxin domain gene gene719 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00720 S101447_00721 S101447_00721 S101447_00721 749515 750876 - hypothetical protein gene gene720 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00721 S101447_00722 S101447_00722 S101447_00722 751004 751513 - hypothetical protein gene gene721 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00722 S101447_00723 S101447_00723 mauA mauA 751516 752103 - Methylamine dehydrogenase (amicyanin) Disulfide bond%3B Electron transport%3B Oxidoreductase%3B Periplasm%3B Signal%3B Transport%3B TTQ%3B Methylamine dehydrogenase carries out the oxidation of methylamine. Electrons are passed from methylamine dehydrogenase to amicyanin. Belongs to the aromatic amine dehydrogenase light chain family%3B KEGG: apt:APA01_04570 methylamine dehydrogenase light chain gene gene722 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00723 S101447_00724 S101447_00724 S101447_00724 752090 752695 - Methylamine utilization protein MauD Membrane%3B Transmembrane%3B Transmembrane helix%3B May be specifically involved in the processing%2C transport%2C and/or maturation of the MADH beta-subunit. Contains 1 thioredoxin domain gene gene723 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00724 S101447_00725 S101447_00725 S101447_00725 752692 753234 - Methylamine utilization protein MauE Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix. gene gene724 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00725 S101447_00726 S101447_00726 mauB mauB 753231 754436 - Methylamine dehydrogenase (amicyanin) Electron transport%3B Oxidoreductase%3B Periplasm%3B Signal%3B Transport%3B Methylamine dehydrogenase carries out the oxidation of methylamine. Electrons are passed from methylamine dehydrogenase to amicyanin. Belongs to the aromatic amine dehydrogenase heavy chain family%3B KEGG: apt:APA01_04540 methylamine dehydrogenase heavy chain gene gene725 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00726 S101447_00727 S101447_00727 S101447_00727 754589 755500 - RuBisCO operon transcriptional regulator Activator%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Trans-acting transcriptional regulator of RuBisCO genes (rbcAB) expression. Contains 1 HTH lysR-type DNA-binding domain gene gene726 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00727 S101447_00728 S101447_00728 S101447_00728 755563 756099 + hypothetical protein gene gene727 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00728 S101447_00729 S101447_00729 S101447_00729 756173 757627 - hypothetical protein gene gene728 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00729 S101447_00730 S101447_00730 S101447_00730 757883 758197 + hypothetical protein gene gene729 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00730 S101447_00731 S101447_00731 gpsA gpsA 758264 759235 + Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) Cytoplasm%3B Lipid biosynthesis%3B Lipid metabolism%3B NAD%3B Oxidoreductase%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family%3B KEGG: apt:APA01_04490 glycerol-3-phosphate dehydrogenase (NAD(P)+) gene gene730 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00731 S101447_00732 S101447_00732 S101447_00732 759392 759925 + DNA protection during starvation protein Cytoplasm%3B DNA condensation%3B DNA-binding%3B Iron%3B Iron storage%3B Metal-binding%3B Oxidoreductase%3B During stationary phase%2C binds the chromosome non- specifically%2C forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral%2C which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions%2C which prevents hydroxyl radical production by the Fenton reaction%3B Belongs to the Dps family gene gene731 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00732 S101447_00733 S101447_00733 S101447_00733 760337 762238 + hypothetical protein gene gene732 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00733 S101447_00734 S101447_00734 S101447_00734 762320 763150 - hypothetical protein gene gene733 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00734 S101447_00735 S101447_00735 asdA asdA 763241 764857 - Aspartate 4-decarboxylase Amino-acid biosynthesis%3B Aminotransferase%3B Decarboxylase%3B Lyase%3B Pyridoxal phosphate%3B Transferase%3B Bifunctional enzyme that has both L-aspartate decarboxylase and transaminase activity%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: apt:APA01_04430 aspartate 4-decarboxylase gene gene734 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00735 S101447_00736 S101447_00736 S101447_00736 764974 766137 - UPF0118 membrane protein YueF Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0118 (PerM) family gene gene735 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00736 S101447_00737 S101447_00737 S101447_00737 766379 766840 - hypothetical protein gene gene736 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00737 S101447_00738 S101447_00738 msrB msrB 766848 767315 - Peptide-methionine (R)-S-oxide reductase Metal-binding%3B Oxidoreductase%3B Zinc%3B Belongs to the MsrB Met sulfoxide reductase family%3B KEGG: apt:APA01_04400 peptide-methionine (R)-S-oxide reductase gene gene737 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00738 S101447_00739 S101447_00739 phrB phrB 767484 768905 + Deoxyribodipyrimidine photo-lyase Chromophore%3B DNA damage%3B DNA repair%3B DNA-binding%3B FAD%3B Flavoprotein%3B Lyase%3B Nucleotide-binding%3B Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration)%2C which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. Belongs to the DNA photolyase class-1 family%3B Contains 1 photolyase/cryptochrome alpha/beta domain%3B KEGG: apk:APA386B_1923 deoxyribodipyrimidine photo-lyase gene gene738 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00739 S101447_00740 S101447_00740 S101447_00740 768975 770666 - hypothetical protein gene gene739 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00740 S101447_00741 S101447_00741 S101447_00741 770874 771959 + hypothetical protein gene gene740 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00741 S101447_00742 S101447_00742 S101447_00742 772162 774993 - Antigen 43 Cell outer membrane%3B Membrane%3B Periplasm%3B Secreted%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Controls colony form variation and autoaggregation. May function as an adhesin%3B Contains 1 autotransporter (TC 1. B. 12) domain gene gene741 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00742 S101447_00743 S101447_00743 S101447_00743 774993 776279 - Glycosyltransferase TibC Glycosyltransferase%3B Transferase%3B Glycosylates the TibA adhesin%3B KEGG: gox:GOX0897 null%3B Hexosyltransferases gene gene742 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00743 S101447_00744 S101447_00744 S101447_00744 776729 778195 + Sodium/iodide cotransporter Congenital hypothyroidism%3B Disease mutation%3B Glycoprotein%3B Ion transport%3B Membrane%3B Phosphoprotein%3B Polymorphism%3B Sodium%3B Sodium transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Mediates iodide uptake in the thyroid gland. Belongs to the sodium:solute symporter (SSF) (TC 2. A. 21) family gene gene743 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00744 S101447_00745 S101447_00745 murQ murQ 778216 779148 + N-acetylmuramic acid 6-phosphate etherase Carbohydrate metabolism%3B Lyase%3B Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate%2C producing GlcNAc 6- phosphate and D-lactate%3B Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily%3B Contains 1 SIS domain%3B KEGG: apt:APA01_04290 N-acetylmuramic acid 6-phosphate etherase gene gene744 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00745 S101447_00746 S101447_00746 nagK nagK 779148 780134 + N-acetylglucosamine kinase ATP-binding%3B Kinase%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Converts endogenous N-acetylglucosamine (GlcNAc)%2C a major component of complex carbohydrates%2C from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity (By similarity)%3B Belongs to the eukaryotic-type N-acetylglucosamine kinase family%3B KEGG: gox:GOX1475 N-acetylglucosamine kinase gene gene745 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00746 S101447_00747 S101447_00747 S101447_00747 780131 782377 + Beta-N-acetylhexosaminidase Carbohydrate metabolism%3B Chitin degradation%3B Glycosidase%3B Hydrolase%3B Periplasm%3B Polysaccharide degradation%3B Hydrolyzes rapidly p-nitrophenyl-N-acetyl-beta-D- glucosaminide (PNP-beta-GlcNAc) and 4-methylumbelliferyl-beta- GlcNAc%2C and slightly active on p-nitrophenyl-beta-GalNAc. Hydrolyzes aryl-N-acetyl-beta-D-glucosaminide (aryl-beta-GlcNAc)%2C aryl-beta-GalNAc and chitin oligosaccharides. This enzyme is not processive%2C i. e. when it hydrolyzes (GlcNAc)n%2C both products%2C (Glc-NAc)n-1 and the terminal GlcNAc%2C are released before the enzyme attacks a second molecule of (GlcNAc)n or (GlcNAc)n-1. Belongs to the glycosyl hydrolase 20 family%3B KEGG: apt:APA01_04270 hexosaminidase gene gene746 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00747 S101447_00748 S101447_00748 S101447_00748 782424 783185 - putative iron export ATP-binding protein FetA ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex FetAB%2C which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene747 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00748 S101447_00749 S101447_00749 S101447_00749 783179 784192 - Vitamin B12 import system permease protein BtuC Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily gene gene748 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00749 S101447_00750 S101447_00750 S101447_00750 784189 785100 - hypothetical protein gene gene749 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00750 S101447_00751 S101447_00751 S101447_00751 785100 787271 - Vitamin B12 transporter BtuB Calcium%3B Cell outer membrane%3B Ion transport%3B Membrane%3B Metal-binding%3B Porin%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB%3B Belongs to the TonB-dependent receptor family. BtuB (TC 1. B. 14. 3. 1) subfamily gene gene750 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00751 S101447_00752 S101447_00752 S101447_00752 787693 789405 - Sodium%2C potassium%2C lithium and rubidium/H(+) antiporter Cell membrane%3B Ion transport%3B Lithium%3B Membrane%3B Potassium%3B Potassium transport%3B Sodium%3B Sodium transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Transporter involved in the efflux of sodium%2C potassium%2C lithium and rubidium%3B Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2. A. 36) family. Nhak (TC 2. A. 36. 3. 2) subfamily gene gene751 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00752 S101447_00753 S101447_00753 S101447_00753 789471 790394 - HTH-type transcriptional regulator PtxR Activator%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Transcriptional activator of the toxA (exotoxin) and regA genes. Contains 1 HTH lysR-type DNA-binding domain gene gene752 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00753 S101447_00754 S101447_00754 S101447_00754 790551 791324 + putative oxidoreductase Oxidoreductase%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: gox:GOX0716 null%3B With NAD(+) or NADP(+) as acceptor gene gene753 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00754 S101447_00755 S101447_00755 S101447_00755 791544 793793 + hypothetical protein gene gene754 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00755 S101447_00756 S101447_00756 S101447_00756 793923 794435 + hypothetical protein gene gene755 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00756 S101447_00757 S101447_00757 S101447_00757 794540 795076 - hypothetical protein gene gene756 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00757 S101447_00758 S101447_00758 S101447_00758 795102 795260 - hypothetical protein gene gene757 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00758 S101447_00759 S101447_00759 S101447_00759 795495 795923 + hypothetical protein gene gene758 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00759 S101447_00760 S101447_00760 S101447_00760 796118 796537 + hypothetical protein gene gene759 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00760 S101447_00761 S101447_00761 S101447_00761 796681 798120 + hypothetical protein gene gene760 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00761 S101447_00762 S101447_00762 S101447_00762 798124 798726 - Phosphoglycerate mutase (2%2C3-diphosphoglycerate-independent) Carbohydrate metabolism%3B Cytoplasm%3B Hydrolase%3B Nucleus%3B Oxidoreductase%3B Ribosome biogenesis%3B Sedoheptulose 1%2C7-bisphosphatase involved in riboneogenesis. Dephosphorylates sedoheptulose 1%2C7-bisphosphate (SBP)%2C which is converted via the non-oxidative pentose phosphate pathway to ribose-5-phosphate. Has a fructose 1%2C6-bisphosphatase activity in vitro%2C but this is probably not biologically relevant%2C since deletion does not affect fructose 1%2C6-biphosphate (FBP) levels%3B Belongs to the phosphoglycerate mutase family. SHB17 subfamily%3B KEGG: apt:APA01_04130 probable phosphoglycerate mutase gene gene761 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00762 S101447_00763 S101447_00763 prpS prpS 798739 799671 - Ribose-phosphate diphosphokinase ATP-binding%3B Cytoplasm%3B Kinase%3B Magnesium%3B Metal-binding%3B Nucleotide biosynthesis%3B Nucleotide-binding%3B Transferase%3B Involved in the biosynthesis of ribose 1%2C5-bisphosphate. Catalyzes the transfer of pyrophosphoryl group from ATP to ribose- 5-phosphate to yield phosphoribosyl diphosphate (PRPP) and AMP%3B Belongs to the ribose-phosphate pyrophosphokinase family%3B KEGG: sfu:Sfum_3652 ribose-phosphate pyrophosphokinase gene gene762 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00763 S101447_00764 S101447_00764 S101447_00764 799652 799759 - hypothetical protein gene gene763 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00764 S101447_00765 S101447_00765 S101447_00765 799756 799878 - hypothetical protein gene gene764 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00765 S101447_00766 S101447_00766 S101447_00766 799906 800826 + O-antigen export system permease protein RfbD Cell inner membrane%3B Cell membrane%3B Membrane%3B Polysaccharide transport%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B May form an ATP-driven O-antigen export apparatus%2C in association with RfbE. Belongs to the ABC-2 integral membrane protein family%3B Contains 1 ABC transmembrane type-2 domain gene gene765 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00766 S101447_00767 S101447_00767 S101447_00767 800832 801638 + Multidrug resistance-associated protein Alternative splicing%3B ATP-binding%3B Cell membrane%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Polymorphism%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport%3B ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion%3B Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3. A. 1. 208) subfamily%3B Contains 2 ABC transmembrane type-1 domains%3B Contains 2 ABC transporter domains gene gene766 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00767 S101447_00768 S101447_00768 S101447_00768 801783 803279 + Multidrug export protein MepA Antibiotic resistance%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Multidrug resistance efflux protein%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family. MepA subfamily gene gene767 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00768 S101447_00769 S101447_00769 S101447_00769 803272 803481 + hypothetical protein gene gene768 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00769 S101447_00770 S101447_00770 bcrC bcrC 803495 804073 + Undecaprenyl-diphosphate phosphatase KEGG: slp:Slip_1721 undecaprenyl-diphosphatase gene gene769 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00770 S101447_00771 S101447_00771 butA butA 804208 805215 + Putative ketoacyl reductase Antibiotic biosynthesis%3B NADP%3B Oxidoreductase%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: pwa:Pecwa_0303 meso-butanediol dehydrogenase / (S%2CS)-butanediol dehydrogenase / diacetyl reductase%3B With NAD(+) or NADP(+) as acceptor gene gene770 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00771 S101447_00772 S101447_00772 S101447_00772 805418 805813 - hypothetical protein gene gene771 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00772 S101447_00773 S101447_00773 ispE ispE 805903 806808 - 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase ATP-binding%3B Isoprene biosynthesis%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol%3B Belongs to the GHMP kinase family. IspE subfamily%3B KEGG: apt:APA01_04030 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase gene gene772 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00773 S101447_00774 S101447_00774 S101447_00774 806805 808667 - Protein O-GlcNAc transferase Repeat%3B TPR repeat%3B Contains 5 TPR repeats%3B KEGG: pxy:105389785 protein O-GlcNAc transferase gene gene773 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00774 S101447_00775 S101447_00775 S101447_00775 808827 809678 + DNA-directed DNA polymerase KEGG: apt:APA01_04010 DNA polymerase bacteriophage-type gene gene774 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00775 S101447_00776 S101447_00776 S101447_00776 809903 811864 + hypothetical protein gene gene775 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00776 S101447_00777 S101447_00777 S101447_00777 812008 813306 - UPF0053 protein CBS domain%3B Cell membrane%3B Membrane%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain gene gene776 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00777 S101447_00778 S101447_00778 S101447_00778 813551 814762 - Cyclic pyranopterin phosphate synthase KEGG: fjo:Fjoh_4636 cyclic pyranopterin phosphate synthase gene gene777 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00778 S101447_00779 S101447_00779 S101447_00779 815186 817213 + 1-deoxy-D-xylulose-5-phosphate synthase Isoprene biosynthesis%3B Magnesium%3B Metal-binding%3B Thiamine biosynthesis%3B Thiamine pyrophosphate%3B Transferase%3B Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)%3B Belongs to the transketolase family. DXPS subfamily%3B KEGG: apt:APA01_03970 1-deoxy-D-xylulose-5-phosphate synthase gene gene778 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00779 S101447_00780 S101447_00780 S101447_00780 817217 817870 + hypothetical protein gene gene779 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00780 S101447_00781 S101447_00781 ugcG ugcG 817947 819116 + Ceramide glucosyltransferase Developmental protein%3B Glycosyltransferase%3B Golgi apparatus%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B Sphingolipid metabolism%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Catalyzes the first glycosylation step in glycosphingolipid biosynthesis%2C the transfer of glucose to ceramide. Glycosphingolipids are required for convergence extension movements during early development%3B Belongs to the glycosyltransferase 2 family%3B KEGG: apt:APA01_03950 ceramide glucosyltransferase gene gene780 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00781 S101447_00782 S101447_00782 acsF acsF 819249 820679 + Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase 4Fe-4S%3B Bacteriochlorophyll biosynthesis%3B Chlorophyll biosynthesis%3B Cobalamin%3B Cobalt%3B Iron%3B Iron-sulfur%3B Metal-binding%3B NADP%3B Oxidoreductase%3B Photosynthesis%3B S-adenosyl-L-methionine%3B Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis in anaerobic conditions. Mediates the cyclase reaction%2C which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)%3B Belongs to the BchE family%3B Contains 1 B12-binding domain%3B KEGG: bur:Bcep18194_A4283 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase gene gene781 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00782 S101447_00783 S101447_00783 chbG chbG 820779 821666 + Chitin disaccharide deacetylase Carbohydrate metabolism%3B Chitin degradation%3B Cytoplasm%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Polysaccharide degradation%3B Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer%2C the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho- beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P%2C the inducer of ChbR and the substrate of ChbF%3B Belongs to the YdjC deacetylase family. ChbG subfamily%3B KEGG: eco:b1733 chitin disaccharide deacetylase gene gene782 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00783 S101447_00784 S101447_00784 S101447_00784 822039 823760 + hypothetical protein gene gene783 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00784 S101447_00785 S101447_00785 S101447_00785 823867 824097 + hypothetical protein gene gene784 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00785 S101447_00786 S101447_00786 S101447_00786 824088 824642 + dCTP deaminase Hydrolase%3B Nucleotide metabolism%3B Belongs to the dCTP deaminase family%3B KEGG: gox:GOX0851 dCTP deaminase gene gene785 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00786 S101447_00787 S101447_00787 murA murA 824651 825913 + UDP-N-acetylglucosamine 1-carboxyvinyltransferase Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Peptidoglycan synthesis%3B Pyruvate%3B Transferase%3B Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine%3B Belongs to the EPSP synthase family. MurA subfamily%3B KEGG: psi:S70_14125 UDP-N-acetylglucosamine 1-carboxyvinyltransferase gene gene786 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00787 S101447_00788 S101447_00788 S101447_00788 825980 826984 - uncharacterized protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix. gene gene787 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00788 S101447_00789 S101447_00789 S101447_00789 827180 827770 - hypothetical protein gene gene788 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00789 S101447_00790 S101447_00790 S101447_00790 827767 829170 - Lactate utilization protein 4Fe-4S%3B Electron transport%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Repeat%3B Transport%3B Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate%3B Belongs to the LutB/YkgF family%3B Contains 2 4Fe-4S ferredoxin-type domains%3B overlaps another CDS with the same product name gene gene789 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00790 S101447_00791 S101447_00791 S101447_00791 829167 829910 - Lactate utilization protein Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source%3B Belongs to the LutA/YkgE family%3B overlaps another CDS with the same product name gene gene790 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00791 S101447_00792 S101447_00792 mdlC mdlC 829942 831636 - Benzoylformate decarboxylase Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B FAD%3B Flavoprotein%3B Magnesium%3B Metal-binding%3B Thiamine pyrophosphate%3B Transferase%3B Belongs to the TPP enzyme family%3B KEGG: apt:APA01_03830 benzoylformate decarboxylase gene gene791 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00792 S101447_00793 S101447_00793 S101447_00793 831636 831842 - hypothetical protein gene gene792 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00793 S101447_00794 S101447_00794 ilvB ilvB 831966 833654 - Acetolactate synthase Acetoin biosynthesis%3B FAD%3B Flavoprotein%3B Magnesium%3B Metal-binding%3B Thiamine pyrophosphate%3B Transferase%3B Belongs to the TPP enzyme family%3B KEGG: apt:APA01_03810 acetolactate synthase I/II/III large subunit gene gene793 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00794 S101447_00795 S101447_00795 alsD alsD 833736 834518 - Acetolactate decarboxylase Acetoin biosynthesis%3B Decarboxylase%3B Lyase%3B Converts acetolactate into acetoin%3B Belongs to the alpha-acetolactate decarboxylase family%3B KEGG: apt:APA01_03800 acetolactate decarboxylase gene gene794 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00795 S101447_00796 S101447_00796 S101447_00796 834621 835580 + HTH-type transcriptional regulator BenM Activator%3B Aromatic hydrocarbons catabolism%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Positive regulator of the ben and cat genes for benzoate degradation. BenM is necessary for ben gene expression but not for expression of the cat genes%2C which can be regulated by CatM. Binds to the inducers cis%2Ccis-muconate and benzoate. Contains 1 HTH lysR-type DNA-binding domain gene gene795 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00796 S101447_00797 S101447_00797 S101447_00797 835586 836464 - Thiosulfate sulfurtransferase Acetylation%3B Alternative splicing%3B Cell junction%3B Cytoplasm%3B Disulfide bond%3B Mitochondrion%3B Phosphoprotein%3B Redox-active center%3B Repeat%3B Synapse%3B Synaptosome%3B Transferase%3B Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT)%2C contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain%2C retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator%2C signaling molecule%2C smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions (By similarity)%3B Contains 2 rhodanese domains%3B KEGG: apt:APA01_03780 thiosulfate/3-mercaptopyruvate sulfurtransferase gene gene796 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00797 S101447_00798 S101447_00798 rlmH rlmH 836576 837031 - 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase Cytoplasm%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA%3B Belongs to the RNA methyltransferase RlmH family%3B KEGG: gox:GOX1150 23S rRNA (pseudouridine1915-N3)-methyltransferase gene gene797 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00798 S101447_00799 S101447_00799 S101447_00799 837087 837548 - Ribosomal silencing factor RsfS Cytoplasm%3B Repressor%3B Translation regulation%3B Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN)%2C blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes%2C thus repressing translation%3B Belongs to the Iojap/RsfS family gene gene798 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00799 S101447_00800 S101447_00800 nadD nadD 837644 838363 - Nicotinate-nucleotide adenylyltransferase ATP-binding%3B NAD%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Pyridine nucleotide biosynthesis%3B Transferase%3B Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)%3B Belongs to the NadD family%3B KEGG: apt:APA01_03750 nicotinate-nucleotide adenylyltransferase gene gene799 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00800 S101447_00801 S101447_00801 proA proA 838375 839700 - Glutamate-5-semialdehyde dehydrogenase Amino-acid biosynthesis%3B Cytoplasm%3B NADP%3B Oxidoreductase%3B Proline biosynthesis%3B Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate%3B Belongs to the gamma-glutamyl phosphate reductase family%3B KEGG: apt:APA01_03740 glutamate-5-semialdehyde dehydrogenase gene gene800 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00801 S101447_00802 S101447_00802 S101447_00802 839790 840884 - Ribosome-binding ATPase ATP-binding%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily%3B Contains 1 OBG-type G (guanine nucleotide-binding) domain gene gene801 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00802 S101447_00803 S101447_00803 pth1 pth1 840884 841465 - Aminoacyl-tRNA hydrolase Cytoplasm%3B Hydrolase%3B The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis%3B Belongs to the PTH family%3B KEGG: dao:Desac_1282 peptidyl-tRNA hydrolase%2C PTH1 family gene gene802 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00803 S101447_00804 S101447_00804 S101447_00804 841562 842179 - 50S ribosomal protein L25 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance%3B Belongs to the ribosomal protein L25P family. CTC subfamily gene gene803 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00804 S101447_00805 S101447_00805 ltaE ltaE 842340 843407 + L-threonine aldolase Lyase%3B Pyridoxal phosphate%3B Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde%3B Belongs to the threonine aldolase family%3B KEGG: apt:APA01_03700 threonine aldolase gene gene804 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00805 S101447_00806 S101447_00806 darS darS 843529 845316 + Aspartate--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn)%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: hoe:IMCC20628_02395 aspartyl-tRNA synthetase gene gene805 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00806 S101447_00807 S101447_00807 S101447_00807 845413 846429 + hypothetical protein gene gene806 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00807 S101447_00808 S101447_00808 S101447_00808 846494 847042 - hypothetical protein gene gene807 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00808 S101447_00809 S101447_00809 S101447_00809 847039 848331 - Aminopeptidase Aminopeptidase%3B Cobalt%3B Hydrolase%3B Metal-binding%3B Metalloprotease%3B Protease%3B Zinc%3B Metal-dependent exopeptidase%3B Belongs to the peptidase M29 family%3B KEGG: apt:APA01_03660 aminopeptidase%3B Aminopeptidases gene gene808 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00809 S101447_00810 S101447_00810 S101447_00810 848482 849048 - hypothetical protein gene gene809 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00810 S101447_00811 S101447_00811 S101447_00811 849145 850293 - putative thylakoid lumen protein Signal%3B Thylakoid. gene gene810 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00811 S101447_00812 S101447_00812 S101447_00812 850335 851597 - Putative metabolite transport protein YncC Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family gene gene811 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00812 S101447_00813 S101447_00813 S101447_00813 851825 853813 - Acetate--CoA ligase Acetylation%3B ATP-binding%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Catalyzes the conversion of acetate into acetyl-CoA (AcCoA)%2C an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction%2C AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction%2C it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA%2C forming the product AcCoA%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: apt:APA01_03620 acetyl-CoA synthetase gene gene812 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00813 S101447_00814 S101447_00814 S101447_00814 853869 854801 - Carboxyvinyl-carboxyphosphonate phosphorylmutase Lyase%3B Magnesium%3B Metal-binding%3B Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R%2C3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate%3B Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family%3B KEGG: apt:APA01_03610 carboxyvinyl-carboxyphosphonate phosphorylmutase gene gene813 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00814 S101447_00815 S101447_00815 prpC prpC 854798 855964 - 2-methylcitrate synthase Transferase%3B Tricarboxylic acid cycle%3B Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield (2S%2C3S)-2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl- CoA but with a lower efficiency%3B Belongs to the citrate synthase family%3B KEGG: apt:APA01_03600 2-methylcitrate synthase gene gene814 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00815 S101447_00816 S101447_00816 prpD prpD 855997 857559 - 2-methylcitrate dehydratase Lyase%3B Tricarboxylic acid cycle%3B Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the stereospecific dehydration of (2S%2C3S)-2- methylcitrate (2-MC) to yield the cis isomer of 2-methyl-aconitate (PubMed:16689789). Could also catalyze the dehydration of citrate and the hydration of cis-aconitate (By similarity)%3B Belongs to the PrpD family%3B KEGG: apt:APA01_03590 2-methylcitrate dehydratase gene gene815 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00816 S101447_00817 S101447_00817 S101447_00817 857600 859105 + Propionyl-CoA carboxylase regulator DNA-binding%3B Transcription%3B Transcription regulation%3B Transcriptional regulator that controls propionyl-CoA assimilation through the methylmalonyl-CoA pathway via regulation of pccB expression%3B Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family%3B Contains 1 HTH cro/C1-type DNA-binding domain gene gene816 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00817 S101447_00818 S101447_00818 S101447_00818 859394 860074 - hypothetical protein gene gene817 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00818 S101447_00819 S101447_00819 S101447_00819 860224 860571 + hypothetical protein gene gene818 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00819 S101447_00820 S101447_00820 S101447_00820 860963 861085 - hypothetical protein gene gene819 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00820 S101447_00821 S101447_00821 S101447_00821 861082 861867 - hypothetical protein gene gene820 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00821 S101447_00822 S101447_00822 S101447_00822 861854 862252 - hypothetical protein gene gene821 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00822 S101447_00823 S101447_00823 S101447_00823 862252 862842 - hypothetical protein gene gene822 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00823 S101447_00824 S101447_00824 S101447_00824 862896 863261 - hypothetical protein gene gene823 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00824 S101447_00825 S101447_00825 S101447_00825 863254 863427 - hypothetical protein gene gene824 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00825 S101447_00826 S101447_00826 S101447_00826 863495 863926 - hypothetical protein gene gene825 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00826 S101447_00827 S101447_00827 S101447_00827 863923 864429 - hypothetical protein gene gene826 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00827 S101447_00828 S101447_00828 S101447_00828 864529 865338 + hypothetical protein gene gene827 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00828 S101447_00829 S101447_00829 S101447_00829 865358 866065 - hypothetical protein gene gene828 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00829 S101447_00830 S101447_00830 S101447_00830 866104 868734 - hypothetical protein gene gene829 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00830 S101447_00831 S101447_00831 S101447_00831 868798 868968 - hypothetical protein gene gene830 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00831 S101447_00832 S101447_00832 S101447_00832 868968 870248 - Epstein-Barr nuclear antigen Activator%3B DNA-binding%3B Host nucleus%3B Host-virus interaction%3B Inhibition of host adaptive immune response by virus%3B Inhibition of host NF-kappa-B by virus%3B Inhibition of host proteasome antigen processing by virus%3B Transcription%3B Transcription regulation%3B Viral immunoevasion%3B Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase%2C the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication%2C oriP. Additionally%2C it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally%2C it can counteract the stabilization of host p53/TP53 by host USP7%2C thereby decreasing apoptosis and increasing host cell survival%3B Belongs to the herpesviridae EBNA1 family gene gene831 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00832 S101447_00833 S101447_00833 S101447_00833 870248 870859 - hypothetical protein gene gene832 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00833 S101447_00834 S101447_00834 S101447_00834 870859 872004 - hypothetical protein gene gene833 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00834 S101447_00835 S101447_00835 S101447_00835 872015 872374 - hypothetical protein gene gene834 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00835 S101447_00836 S101447_00836 S101447_00836 872371 873021 - hypothetical protein gene gene835 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00836 S101447_00837 S101447_00837 S101447_00837 873014 874210 - hypothetical protein gene gene836 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00837 S101447_00838 S101447_00838 S101447_00838 874207 874416 - hypothetical protein gene gene837 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00838 S101447_00839 S101447_00839 S101447_00839 874417 875340 - hypothetical protein gene gene838 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00839 S101447_00840 S101447_00840 S101447_00840 875437 875703 - hypothetical protein gene gene839 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00840 S101447_00841 S101447_00841 S101447_00841 875937 876728 - hypothetical protein gene gene840 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00841 S101447_00842 S101447_00842 S101447_00842 876838 877059 - hypothetical protein gene gene841 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00842 S101447_00843 S101447_00843 S101447_00843 877125 877925 - DNA-directed DNA polymerase KEGG: mag:amb1930 DNA polymerase bacteriophage-type gene gene842 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00843 S101447_00844 S101447_00844 S101447_00844 878010 878207 + hypothetical protein gene gene843 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00844 S101447_00845 S101447_00845 S101447_00845 878276 878902 + hypothetical protein gene gene844 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00845 S101447_00846 S101447_00846 S101447_00846 879309 879515 + hypothetical protein gene gene845 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00846 S101447_00847 S101447_00847 S101447_00847 879475 879915 + hypothetical protein gene gene846 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00847 S101447_00848 S101447_00848 S101447_00848 879973 880302 + Non-specific serine/threonine protein kinase KEGG: mjd:JDM601_1345 serine/threonine protein kinase%2C bacterial gene gene847 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00848 S101447_00849 S101447_00849 S101447_00849 880319 881458 - hypothetical protein gene gene848 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00849 S101447_00850 S101447_00850 S101447_00850 881518 883839 - hypothetical protein gene gene849 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00850 S101447_00851 S101447_00851 S101447_00851 883983 884987 + hypothetical protein gene gene850 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00851 S101447_00852 S101447_00852 S101447_00852 885160 885666 - hypothetical protein gene gene851 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00852 S101447_00853 S101447_00853 S101447_00853 885835 886158 - hypothetical protein gene gene852 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00853 S101447_00854 S101447_00854 S101447_00854 886155 886586 - hypothetical protein gene gene853 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00854 S101447_00855 S101447_00855 S101447_00855 886590 888074 - hypothetical protein gene gene854 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00855 S101447_00856 S101447_00856 S101447_00856 888074 888280 - hypothetical protein gene gene855 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00856 S101447_00857 S101447_00857 S101447_00857 888295 889341 - hypothetical protein gene gene856 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00857 S101447_00858 S101447_00858 S101447_00858 889341 890027 - hypothetical protein gene gene857 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00858 S101447_00859 S101447_00859 S101447_00859 890027 890215 - hypothetical protein gene gene858 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00859 S101447_00860 S101447_00860 S101447_00860 890215 890424 - hypothetical protein gene gene859 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00860 S101447_00861 S101447_00861 S101447_00861 890384 890773 - hypothetical protein gene gene860 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00861 S101447_00862 S101447_00862 S101447_00862 890780 891169 - hypothetical protein gene gene861 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00862 S101447_00863 S101447_00863 S101447_00863 891169 891390 - hypothetical protein gene gene862 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00863 S101447_00864 S101447_00864 S101447_00864 891390 892502 - hypothetical protein gene gene863 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00864 S101447_00865 S101447_00865 S101447_00865 892537 893742 - Putative lambdoid prophage Rac integrase DNA integration%3B DNA recombination%3B Viral genome integration%3B Virus entry into host cell%3B Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase%2C integrase is also necessary for excision of the prophage from the host genome (By similarity)%3B Belongs to the 'phage' integrase family gene gene864 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00865 S101447_00866 S101447_00866 S101447_00866 893748 894041 - hypothetical protein gene gene865 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00866 S101447_00867 S101447_00867 S101447_00867 894038 894298 - hypothetical protein gene gene866 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00867 S101447_00868 S101447_00868 S101447_00868 894295 894561 - hypothetical protein gene gene867 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00868 S101447_00869 S101447_00869 S101447_00869 894558 894797 - hypothetical protein gene gene868 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00869 S101447_00870 S101447_00870 S101447_00870 894797 895003 - hypothetical protein gene gene869 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00870 S101447_00871 S101447_00871 S101447_00871 895000 895179 - hypothetical protein gene gene870 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00871 S101447_00872 S101447_00872 S101447_00872 895350 895547 + hypothetical protein gene gene871 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00872 S101447_00873 S101447_00873 S101447_00873 895652 896149 + hypothetical protein gene gene872 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00873 S101447_00874 S101447_00874 S101447_00874 896198 897541 - hypothetical protein gene gene873 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00874 S101447_00875 S101447_00875 S101447_00875 897529 898041 - hypothetical protein gene gene874 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00875 S101447_00876 S101447_00876 S101447_00876 898038 898313 - hypothetical protein gene gene875 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00876 S101447_00877 S101447_00877 S101447_00877 898383 900470 - hypothetical protein gene gene876 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00877 S101447_00878 S101447_00878 S101447_00878 900476 900937 - hypothetical protein gene gene877 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00878 S101447_00879 S101447_00879 S101447_00879 901115 901546 - hypothetical protein gene gene878 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00879 S101447_00880 S101447_00880 S101447_00880 901543 901746 - hypothetical protein gene gene879 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00880 S101447_00881 S101447_00881 S101447_00881 901788 902216 - hypothetical protein gene gene880 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00881 S101447_00882 S101447_00882 S101447_00882 902228 902884 - hypothetical protein gene gene881 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00882 S101447_00883 S101447_00883 S101447_00883 902920 903348 - hypothetical protein gene gene882 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00883 S101447_00884 S101447_00884 S101447_00884 903653 904861 - hypothetical protein gene gene883 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00884 S101447_00885 S101447_00885 S101447_00885 904858 905499 - hypothetical protein gene gene884 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00885 S101447_00886 S101447_00886 S101447_00886 905637 905891 - hypothetical protein gene gene885 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00886 S101447_00887 S101447_00887 S101447_00887 905985 906320 - hypothetical protein gene gene886 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00887 S101447_00888 S101447_00888 S101447_00888 906401 907045 - hypothetical protein gene gene887 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00888 S101447_00889 S101447_00889 S101447_00889 907093 908610 - hypothetical protein gene gene888 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00889 S101447_00890 S101447_00890 S101447_00890 908610 910109 - uncharacterized protein gene gene889 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00890 S101447_00891 S101447_00891 S101447_00891 910090 910563 - hypothetical protein gene gene890 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00891 S101447_00892 S101447_00892 S101447_00892 910708 911013 - hypothetical protein gene gene891 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00892 S101447_00893 S101447_00893 S101447_00893 911109 911666 - hypothetical protein gene gene892 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00893 S101447_00894 S101447_00894 S101447_00894 912099 912299 - hypothetical protein gene gene893 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00894 S101447_00895 S101447_00895 S101447_00895 912277 912513 - hypothetical protein gene gene894 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00895 S101447_00896 S101447_00896 S101447_00896 912622 914121 - DNA helicase ATP-binding%3B DNA replication%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Primosome%3B Participates in initiation and elongation during chromosome replicatio%3B it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding%2C DNA binding%2C and interaction with DnaC protein%2C primase%2C and other prepriming proteins%3B Belongs to the helicase family. DnaB subfamily%3B Contains 1 SF4 helicase domain%3B KEGG: cua:CU7111_1904 replicative DNA helicase gene gene895 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00896 S101447_00897 S101447_00897 S101447_00897 914118 915011 - hypothetical protein gene gene896 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00897 S101447_00898 S101447_00898 S101447_00898 915011 915238 - hypothetical protein gene gene897 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00898 S101447_00899 S101447_00899 S101447_00899 915245 915967 - hypothetical protein gene gene898 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00899 S101447_00900 S101447_00900 S101447_00900 915922 916344 - hypothetical protein gene gene899 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00900 S101447_00901 S101447_00901 S101447_00901 916341 916544 - hypothetical protein gene gene900 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00901 S101447_00902 S101447_00902 S101447_00902 916548 916820 - UPF0335 protein Plasmid%3B Belongs to the UPF0335 family gene gene901 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00902 S101447_00903 S101447_00903 S101447_00903 916820 917053 - hypothetical protein gene gene902 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00903 S101447_00904 S101447_00904 S101447_00904 917112 917501 - hypothetical protein gene gene903 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00904 S101447_00905 S101447_00905 S101447_00905 917600 917839 + hypothetical protein gene gene904 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00905 S101447_00906 S101447_00906 S101447_00906 917841 918221 - hypothetical protein gene gene905 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00906 S101447_00907 S101447_00907 S101447_00907 918221 918673 - hypothetical protein gene gene906 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00907 S101447_00908 S101447_00908 S101447_00908 918976 919350 + Repressor LexA DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Repressor of PBSX. Binds to four sites close to its own gene. Necessary for the maintenance of the lysogenic state%3B Contains 1 HTH cro/C1-type DNA-binding domain%3B KEGG: ddh:Desde_3216 repressor LexA gene gene907 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00908 S101447_00909 S101447_00909 S101447_00909 919475 920404 + hypothetical protein gene gene908 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00909 S101447_00910 S101447_00910 S101447_00910 920541 920654 + hypothetical protein gene gene909 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00910 S101447_00911 S101447_00911 S101447_00911 920852 921565 + hypothetical protein gene gene910 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00911 S101447_00912 S101447_00912 S101447_00912 921577 921810 + hypothetical protein gene gene911 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00912 S101447_00913 S101447_00913 S101447_00913 921889 922209 + hypothetical protein gene gene912 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00913 S101447_00914 S101447_00914 S101447_00914 922206 922400 + hypothetical protein gene gene913 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00914 S101447_00915 S101447_00915 S101447_00915 922400 923158 + hypothetical protein gene gene914 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00915 S101447_00916 S101447_00916 S101447_00916 923155 923781 + hypothetical protein gene gene915 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00916 S101447_00917 S101447_00917 S101447_00917 923778 924368 + DNA-directed DNA polymerase KEGG: xau:Xaut_3681 DNA polymerase III subunit epsilon gene gene916 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00917 S101447_00918 S101447_00918 S101447_00918 924365 924667 + hypothetical protein gene gene917 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00918 S101447_00919 S101447_00919 S101447_00919 924664 925041 + hypothetical protein gene gene918 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00919 S101447_00920 S101447_00920 S101447_00920 925041 925283 + hypothetical protein gene gene919 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00920 S101447_00921 S101447_00921 S101447_00921 925276 925680 + hypothetical protein gene gene920 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00921 S101447_00922 S101447_00922 S101447_00922 925677 926186 + hypothetical protein gene gene921 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00922 S101447_00923 S101447_00923 S101447_00923 926183 926602 + hypothetical protein gene gene922 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00923 S101447_00924 S101447_00924 S101447_00924 926595 926825 + hypothetical protein gene gene923 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00924 S101447_00925 S101447_00925 S101447_00925 926822 927862 + hypothetical protein gene gene924 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00925 S101447_00926 S101447_00926 S101447_00926 928033 928818 - hypothetical protein gene gene925 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00926 S101447_00927 S101447_00927 S101447_00927 928963 929355 + hypothetical protein gene gene926 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00927 S101447_00928 S101447_00928 S101447_00928 929647 930747 + hypothetical protein gene gene927 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00928 S101447_00929 S101447_00929 S101447_00929 930810 931022 - hypothetical protein gene gene928 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00929 S101447_00930 S101447_00930 S101447_00930 931155 932012 - hypothetical protein gene gene929 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00930 S101447_00931 S101447_00931 S101447_00931 932228 932953 + hypothetical protein gene gene930 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00931 S101447_00932 S101447_00932 S101447_00932 933176 933298 - hypothetical protein gene gene931 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00932 S101447_00933 S101447_00933 S101447_00933 933295 933495 - hypothetical protein gene gene932 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00933 S101447_00934 S101447_00934 S101447_00934 933498 933878 - hypothetical protein gene gene933 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00934 S101447_00935 S101447_00935 S101447_00935 933875 934243 - hypothetical protein gene gene934 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00935 S101447_00936 S101447_00936 S101447_00936 934236 934400 - hypothetical protein gene gene935 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00936 S101447_00937 S101447_00937 S101447_00937 934400 934831 - hypothetical protein gene gene936 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00937 S101447_00938 S101447_00938 S101447_00938 934828 935334 - hypothetical protein gene gene937 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00938 S101447_00939 S101447_00939 S101447_00939 935386 936807 - hypothetical protein gene gene938 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00939 S101447_00940 S101447_00940 S101447_00940 936767 937177 - hypothetical protein gene gene939 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00940 S101447_00941 S101447_00941 S101447_00941 937177 937509 - hypothetical protein gene gene940 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00941 S101447_00942 S101447_00942 S101447_00942 937496 938215 - hypothetical protein gene gene941 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00942 S101447_00943 S101447_00943 S101447_00943 938222 938947 - hypothetical protein gene gene942 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00943 S101447_00944 S101447_00944 S101447_00944 939346 939486 + hypothetical protein gene gene943 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00944 S101447_00945 S101447_00945 S101447_00945 939517 939735 + hypothetical protein gene gene944 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00945 S101447_00946 S101447_00946 S101447_00946 939854 941524 - hypothetical protein gene gene945 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00946 S101447_00947 S101447_00947 S101447_00947 941718 942323 + resolvase DNA integration%3B DNA recombination%3B DNA-binding%3B Plasmid%3B Transposable element%3B Resolvase catalyzes the resolution (a site-specific recombination) of the cointegrated replicon to yield the final transposition products. Belongs to the site-specific recombinase resolvase family%3B Contains 1 resolvase/invertase-type recombinase catalytic domain gene gene946 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00947 S101447_00948 S101447_00948 S101447_00948 942705 942779 - tRNA-Val tRNA gene947 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00948 S101447_00949 S101447_00949 S101447_00949 942848 943774 + N-formylglutamate deformylase KEGG: gdj:Gdia_3369 N-formylglutamate deformylase gene gene948 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00949 S101447_00950 S101447_00950 S101447_00950 943880 945757 + Chaperone protein HtpG ATP-binding%3B Chaperone%3B Cytoplasm%3B Nucleotide-binding%3B Stress response%3B Molecular chaperone. Has ATPase activity%3B Belongs to the heat shock protein 90 family gene gene949 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00950 S101447_00951 S101447_00951 S101447_00951 946016 946543 + hypothetical protein gene gene950 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00951 S101447_00952 S101447_00952 mazG mazG 946619 947524 - ATP diphosphatase ATP-binding%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazE-MazF toxin-antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation%2C thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs%2C which are substrates for (p)ppGpp synthesis by RelA (By similarity)%3B Belongs to the nucleoside triphosphate pyrophosphohydrolase family%3B KEGG: apt:APA01_03320 ATP diphosphatase gene gene951 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00952 S101447_00953 S101447_00953 argC argC 947669 948589 + N-acetyl-gamma-glutamyl-phosphate reductase Amino-acid biosynthesis%3B Arginine biosynthesis%3B Cytoplasm%3B NADP%3B Oxidoreductase%3B Belongs to the NAGSA dehydrogenase family. Type 2 subfamily%3B KEGG: apt:APA01_03310 N-acetyl-gamma-glutamyl-phosphate reductase gene gene952 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00953 S101447_00954 S101447_00954 S101447_00954 948627 949358 + 3-oxoacyl-[acyl-carrier-protein] reductase NADP%3B Oxidoreductase%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: eec:EcWSU1_01122 3-oxoacyl-(acyl-carrier protein) reductase gene gene953 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00954 S101447_00955 S101447_00955 S101447_00955 949458 950852 - hypothetical protein gene gene954 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00955 S101447_00956 S101447_00956 S101447_00956 951135 951395 + hypothetical protein gene gene955 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00956 S101447_00957 S101447_00957 S101447_00957 951490 952794 + Microcin H47 secretion protein MchE Bacteriocin transport%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Probably involved%2C in conjunction with MchF%2C in the secretion of microcin H47. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene956 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00957 S101447_00958 S101447_00958 S101447_00958 952794 954950 + Colicin V secretion/processing ATP-binding protein CvaB ATP-binding%3B Bacteriocin transport%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Plasmid%3B Protease%3B Protein transport%3B Thiol protease%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved%2C in conjunction with CvaA%2C in the secretion of colicin V. Belongs to the ABC transporter superfamily. Colicin V exporter (TC 3. A. 1. 110. 2) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B Contains 1 peptidase C39 domain gene gene957 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00958 S101447_00959 S101447_00959 S101447_00959 954966 955982 - Alcohol dehydrogenase Cytoplasm%3B NADP%3B Oxidoreductase%3B Catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA. Is essential for growth with 3-hydroxypropanoate as a sole carbon source. Restores acrylate resistance when expressed in the E. coli strain K12 acuI deletion%3B Belongs to the zinc-containing alcohol dehydrogenase family. Acrylyl-CoA reductase subfamily%3B KEGG: azo:azo3317 alcohol dehydrogenase gene gene958 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00959 S101447_00960 S101447_00960 S101447_00960 956187 957494 + UPF0053 inner membrane protein CBS domain%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain gene gene959 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00960 S101447_00961 S101447_00961 appA appA 957491 958786 + 4-phytase Disulfide bond%3B Hydrolase%3B Multifunctional enzyme%3B Periplasm%3B Signal%3B Belongs to the histidine acid phosphatase family%3B KEGG: apt:APA01_03230 4-phytase / acid phosphatase gene gene960 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00961 S101447_00962 S101447_00962 S101447_00962 958836 959687 - hypothetical protein gene gene961 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00962 S101447_00963 S101447_00963 S101447_00963 959923 960366 + hypothetical protein gene gene962 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00963 S101447_00964 S101447_00964 S101447_00964 960471 962132 - hypothetical protein gene gene963 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00964 S101447_00965 S101447_00965 S101447_00965 962304 963326 - Phosphate-binding protein PstS Periplasm%3B Phosphate transport%3B Signal%3B Transport%3B Part of the ABC transporter complex PstSACB involved in phosphate import%3B Belongs to the PstS family gene gene964 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00965 S101447_00966 S101447_00966 phoR phoR 963412 964719 - Histidine kinase ATP-binding%3B Cell membrane%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphate transport%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Two-component regulatory system%3B Member of the two-component regulatory system PhoP/PhoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoP in response to environmental signals. Contains 1 histidine kinase domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: apt:APA01_03180 two-component system%2C OmpR family%2C phosphate regulon sensor histidine kinase PhoR gene gene965 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00966 S101447_00967 S101447_00967 S101447_00967 964739 965428 - Protein PilH Phosphoprotein%3B Two-component regulatory system%3B May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). Contains 1 response regulatory domain gene gene966 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00967 S101447_00968 S101447_00968 purA purA 965651 966940 - Adenylosuccinate synthase Cytoplasm%3B GTP-binding%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Purine biosynthesis%3B Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP%3B Belongs to the adenylosuccinate synthetase family%3B KEGG: ccr:CC_3103 adenylosuccinate synthase gene gene967 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00968 S101447_00969 S101447_00969 S101447_00969 967006 968190 - ATP phosphoribosyltransferase regulatory subunit Amino-acid biosynthesis%3B Cytoplasm%3B Histidine biosynthesis%3B Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine%3B Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily gene gene968 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00969 S101447_00970 S101447_00970 S101447_00970 968243 969721 - hypothetical protein gene gene969 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00970 S101447_00971 S101447_00971 S101447_00971 969718 970977 - uncharacterized protein gene gene970 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00971 S101447_00972 S101447_00972 trpA trpA 971011 971844 - Tryptophan synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Lyase%3B Tryptophan biosynthesis%3B The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate%3B Belongs to the TrpA family%3B KEGG: aci:ACIAD0642 tryptophan synthase alpha chain%3B overlaps another CDS with the same product name gene gene971 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00972 S101447_00973 S101447_00973 trpB trpB 971841 973085 - Tryptophan synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Lyase%3B Pyridoxal phosphate%3B Tryptophan biosynthesis%3B The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine%3B Belongs to the TrpB family%3B KEGG: apt:APA01_03110 tryptophan synthase beta chain%3B overlaps another CDS with the same product name gene gene972 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00973 S101447_00974 S101447_00974 S101447_00974 973360 974538 + Magnesium transport protein Cell inner membrane%3B Cell membrane%3B Ion transport%3B Magnesium%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Mediates influx of magnesium ions%3B Belongs to the CorA metal ion transporter (MIT) (TC 1. A. 35) family gene gene973 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00974 S101447_00975 S101447_00975 S101447_00975 974540 975073 + hypothetical protein gene gene974 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00975 S101447_00976 S101447_00976 S101447_00976 975308 976606 + Transcription termination factor ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B RNA-binding%3B Transcription%3B Transcription regulation%3B Transcription termination%3B Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA%2C activation of Rho's RNA-dependent ATPase activity%2C and release of the mRNA from the DNA template%3B Belongs to the Rho family gene gene975 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00976 S101447_00977 S101447_00977 S101447_00977 976668 976961 - hypothetical protein gene gene976 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00977 S101447_00978 S101447_00978 S101447_00978 977127 977609 + Ferric uptake regulation protein Cytoplasm%3B DNA-binding%3B Iron%3B Metal-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Zinc%3B Acts as a global negative controlling element%2C employing Fe(2+) as a cofactor to bind the operator of the repressed genes%3B Belongs to the Fur family gene gene977 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00978 S101447_00979 S101447_00979 S101447_00979 977606 978454 + hypothetical protein gene gene978 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00979 S101447_00980 S101447_00980 S101447_00980 978519 980165 + Apolipoprotein N-acyltransferase Acyltransferase%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Transfers the fatty acyl group on membrane lipoproteins%3B Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily%3B Contains 1 CN hydrolase domain%3B KEGG: apt:APA01_03040 apolipoprotein N-acyltransferase%3B Transferring groups other than amino-acyl groups gene gene979 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00980 S101447_00981 S101447_00981 S101447_00981 980330 980824 + putative transcriptional regulator in ATPase CF(0) region DNA-binding%3B Transcription%3B Transcription regulation%3B Contains 1 HTH cro/C1-type DNA-binding domain gene gene980 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00981 S101447_00982 S101447_00982 S101447_00982 980866 981690 - Epstein-Barr nuclear antigen Activator%3B DNA-binding%3B Host nucleus%3B Host-virus interaction%3B Inhibition of host adaptive immune response by virus%3B Inhibition of host NF-kappa-B by virus%3B Inhibition of host proteasome antigen processing by virus%3B Transcription%3B Transcription regulation%3B Viral immunoevasion%3B Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase%2C the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication%2C oriP. Additionally%2C it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally%2C it can counteract the stabilization of host p53/TP53 by host USP7%2C thereby decreasing apoptosis and increasing host cell survival (By similarity)%3B Belongs to the herpesviridae EBNA1 family gene gene981 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00982 S101447_00983 S101447_00983 glyQ glyQ 981766 982812 + Glycine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: apt:APA01_03010 glycyl-tRNA synthetase alpha chain gene gene982 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00983 S101447_00984 S101447_00984 glyS glyS 982817 984877 + Glycine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: pla:Plav_0728 glycyl-tRNA synthetase beta chain gene gene983 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00984 S101447_00985 S101447_00985 S101447_00985 985100 986059 + Inner membrane protein YtfF Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Contains 1 EamA domain gene gene984 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00985 S101447_00986 S101447_00986 S101447_00986 986069 986239 - UPF0391 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0391 family gene gene985 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00986 S101447_00987 S101447_00987 S101447_00987 986372 987130 - hypothetical protein gene gene986 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00987 S101447_00988 S101447_00988 purH purH 987252 988829 - Phosphoribosylaminoimidazolecarboxamide formyltransferase Hydrolase%3B Multifunctional enzyme%3B Purine biosynthesis%3B Transferase%3B Belongs to the PurH family%3B KEGG: apt:APA01_02950 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase gene gene987 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00988 S101447_00989 S101447_00989 trmB trmB 988928 989665 - tRNA (guanine(46)-N(7))-methyltransferase Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B tRNA processing%3B Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family%3B KEGG: apt:APA01_02940 tRNA (guanine-N7-)-methyltransferase gene gene988 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00989 S101447_00990 S101447_00990 metK metK 989684 990871 - Methionine adenosyltransferase ATP-binding%3B Cobalt%3B Cytoplasm%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B One-carbon metabolism%3B Potassium%3B Transferase%3B Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps%2C AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme%3B Belongs to the AdoMet synthase family%3B KEGG: apt:APA01_02930 S-adenosylmethionine synthetase gene gene989 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00990 S101447_00991 S101447_00991 dapB dapB 991060 991839 - 4-hydroxy-tetrahydrodipicolinate reductase Amino-acid biosynthesis%3B Cytoplasm%3B Diaminopimelate biosynthesis%3B Lysine biosynthesis%3B NAD%3B NADP%3B Oxidoreductase%3B Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate%3B Belongs to the DapB family%3B KEGG: gxy:GLX_18190 4-hydroxy-tetrahydrodipicolinate reductase gene gene990 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00991 S101447_00992 S101447_00992 S101447_00992 991846 992988 - Chaperone protein DnaJ Chaperone%3B Cytoplasm%3B DNA replication%3B Metal-binding%3B Repeat%3B Stress response%3B Zinc%3B Zinc-finger%3B Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins%2C also in an autonomous%2C DnaK-independent fashion. Unfolded proteins bind initially to Dna%3B upon interaction with the DnaJ-bound protein%2C DnaK hydrolyzes its bound ATP%2C resulting in the formation of a stable complex. GrpE releases ADP from Dna%3B ATP binding to DnaK triggers the release of the substrate protein%2C thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ%2C DnaK and GrpE are required for fully efficient folding. Also involved%2C together with DnaK and GrpE%2C in the DNA replication of plasmids through activation of initiation proteins%3B Belongs to the DnaJ family%3B Contains 1 CR-type zinc finger%3B Contains 1 J domain gene gene991 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00992 S101447_00993 S101447_00993 S101447_00993 993144 995048 - Chaperone protein DnaK ATP-binding%3B Chaperone%3B Nucleotide-binding%3B Phosphoprotein%3B Stress response%3B Acts as a chaperone%3B Belongs to the heat shock protein 70 family gene gene992 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00993 S101447_00994 S101447_00994 S101447_00994 995111 995239 - hypothetical protein gene gene993 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00994 S101447_00995 S101447_00995 S101447_00995 995255 995887 - Protein GrpE Chaperone%3B Cytoplasm%3B Stress response%3B Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins%2C in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to Dna%3B upon interaction with the DnaJ-bound protein%2C DnaK hydrolyzes its bound ATP%2C resulting in the formation of a stable complex. GrpE releases ADP from Dna%3B ATP binding to DnaK triggers the release of the substrate protein%2C thus completing the reaction cycle. Several rounds of ATP- dependent interactions between DnaJ%2C DnaK and GrpE are required for fully efficient folding%3B Belongs to the GrpE family gene gene994 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00995 S101447_00996 S101447_00996 S101447_00996 996045 996758 + Transcriptional regulatory protein ChvI Cytoplasm%3B DNA-binding%3B Exopolysaccharide synthesis%3B Magnesium%3B Metal-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system%3B Member of a two-component regulatory system ChvG(ExoS)/ChvI involved in regulating the production of succinoglycan. Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene995 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00996 S101447_00997 S101447_00997 chvG chvG 996768 998570 + Histidine kinase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system%3B Member of a two-component regulatory system ChvG/ChvI. Activates ChvI by phosphorylation (Potential)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: apt:APA01_02870 two-component system%2C OmpR family%2C sensor histidine kinase ChvG gene gene996 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00997 S101447_00998 S101447_00998 S101447_00998 998591 998989 - hypothetical protein gene gene997 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00998 S101447_00999 S101447_00999 S101447_00999 999254 1000234 + Nucleotide-binding protein ATP-binding%3B GTP-binding%3B Nucleotide-binding%3B Displays ATPase and GTPase activities%3B Belongs to the RapZ-like family gene gene998 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_00999 S101447_01000 S101447_01000 S101447_01000 1000260 1000868 - UPF0301 protein Belongs to the UPF0301 (AlgH) family gene gene999 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01000 S101447_01001 S101447_01001 S101447_01001 1000983 1001900 + Polyphosphate kinase KEGG: bma:BMA0166 polyphosphate kinase gene gene1000 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01001 S101447_01002 S101447_01002 S101447_01002 1001907 1002410 + hypothetical protein gene gene1001 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01002 S101447_01003 S101447_01003 S101447_01003 1002501 1004846 - ClpA like protein ATP-binding%3B Chaperone%3B Nucleotide-binding%3B Repeat%3B Belongs to the ClpA/ClpB family gene gene1002 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01003 S101447_01004 S101447_01004 S101447_01004 1005013 1005390 - ATP-dependent Clp protease adapter protein ClpS Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation%3B Belongs to the ClpS family gene gene1003 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01004 S101447_01005 S101447_01005 S101447_01005 1005705 1006853 + Serine-type D-Ala-D-Ala carboxypeptidase Carboxypeptidase%3B Cell shape%3B Cell wall biogenesis/degradation%3B Hydrolase%3B Peptidoglycan synthesis%3B Protease%3B Secreted%3B Signal%3B Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Belongs to the peptidase S11 family%3B KEGG: apt:APA01_02790 D-alanyl-D-alanine carboxypeptidase gene gene1004 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01005 S101447_01006 S101447_01006 S101447_01006 1006978 1007778 + Methionyl aminopeptidase Aminopeptidase%3B Hydrolase%3B Metal-binding%3B Protease%3B Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-%2C Cys%2C Gly%2C Pro%2C Ser%2C Thr%2C or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed%3B Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily%3B KEGG: apt:APA01_02780 methionyl aminopeptidase gene gene1005 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01006 S101447_01007 S101447_01007 S101447_01007 1007785 1009605 + Gamma-glutamyltransferase Acyltransferase%3B Antibiotic resistance%3B Hydrolase%3B Transferase%3B Zymogen%3B Besides the cephalosporin acylase I activity which converts GL-7ACA into 7-AC%3B this enzyme displays some gamma glutamyltranspeptidase activity. Belongs to the gamma-glutamyltransferase family%3B KEGG: apt:APA01_02770 gamma-glutamyltranspeptidase / glutathione hydrolase gene gene1006 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01007 S101447_01008 S101447_01008 kamA kamA 1009608 1010657 - Lysine 2%2C3-aminomutase 4Fe-4S%3B Iron%3B Iron-sulfur%3B Isomerase%3B Metal-binding%3B Pyridoxal phosphate%3B S-adenosyl-L-methionine%3B With EpmA is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. EpmB appears to act before EpmA. Displays lysine 2%2C3-aminomutase activity%2C producing (R)-beta-lysine from (S)-alpha-lysine (L-lysine) (By similarity)%3B Belongs to the radical SAM superfamily. KamA family%3B KEGG: apt:APA01_02760 lysine 2%2C3-aminomutase gene gene1007 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01008 S101447_01009 S101447_01009 poxA poxA 1010678 1011703 + Lysine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: apt:APA01_02750 lysyl-tRNA synthetase%2C class II gene gene1008 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01009 S101447_01010 S101447_01010 S101447_01010 1011795 1012205 + hypothetical protein gene gene1009 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01010 S101447_01011 S101447_01011 S101447_01011 1012279 1013253 + hypothetical protein gene gene1010 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01011 S101447_01012 S101447_01012 S101447_01012 1013354 1013803 - hypothetical protein gene gene1011 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01012 S101447_01013 S101447_01013 S101447_01013 1013941 1014513 - Thiamine phosphate synthase Magnesium%3B Metal-binding%3B Thiamine biosynthesis%3B Transferase%3B Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)%3B Belongs to the thiamine-phosphate synthase family%3B KEGG: ptp:RCA23_c12830 thiamine-phosphate pyrophosphorylase gene gene1012 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01013 S101447_01014 S101447_01014 fbaB fbaB 1014558 1015472 - Fructose-bisphosphate aldolase Cytoplasm%3B Glycolysis%3B Lyase%3B Schiff base%3B Belongs to the DeoC/FbaB aldolase family. FbaB subfamily%3B KEGG: zmo:ZMO0179 fructose-bisphosphate aldolase%2C class I gene gene1013 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01014 S101447_01015 S101447_01015 S101447_01015 1015469 1015918 - hypothetical protein gene gene1014 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01015 S101447_01016 S101447_01016 S101447_01016 1016070 1016357 + hypothetical protein gene gene1015 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01016 S101447_01017 S101447_01017 S101447_01017 1016364 1016732 + hypothetical protein gene gene1016 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01017 S101447_01018 S101447_01018 S101447_01018 1016854 1017441 + 5-formyltetrahydrofolate cyclo-ligase KEGG: apt:APA01_02560 5-formyltetrahydrofolate cyclo-ligase gene gene1017 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01018 S101447_01019 S101447_01019 S101447_01019 1017466 1018281 + uncharacterized protein gene gene1018 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01019 S101447_01020 S101447_01020 mutT mutT 1018309 1018728 - 8-oxo-dGTP diphosphatase Hydrolase%3B Contains 1 nudix hydrolase domain%3B KEGG: rrd:RradSPS_1263 8-oxo-dGTP diphosphatase gene gene1019 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01020 S101447_01021 S101447_01021 S101447_01021 1018725 1019603 - hypothetical protein gene gene1020 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01021 S101447_01022 S101447_01022 pyrD pyrD 1019600 1020673 - Dihydroorotate dehydrogenase (quinone) Cell membrane%3B Flavoprotein%3B FMN%3B Membrane%3B Oxidoreductase%3B Pyrimidine biosynthesis%3B Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor%3B Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily%3B KEGG: apt:APA01_02520 dihydroorotate dehydrogenase gene gene1021 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01022 S101447_01023 S101447_01023 S101447_01023 1020851 1021468 + hypothetical protein gene gene1022 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01023 S101447_01024 S101447_01024 dpo4 dpo4 1021721 1022800 + DNA-directed DNA polymerase Cytoplasm%3B DNA damage%3B DNA repair%3B DNA replication%3B DNA-binding%3B DNA-directed DNA polymerase%3B Magnesium%3B Metal-binding%3B Mutator protein%3B Nucleotidyltransferase%3B Transferase%3B Poorly processive%2C error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks%2C which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis%2C in conjunction with the beta clamp from PolIII%3B Belongs to the DNA polymerase type-Y family%3B Contains 1 umuC domain%3B KEGG: apt:APA01_02490 DNA polymerase IV gene gene1023 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01024 S101447_01025 S101447_01025 S101447_01025 1023059 1024531 + L-asparagine permease Amino-acid transport%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2. A. 3. 1) family gene gene1024 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01025 S101447_01026 S101447_01026 S101447_01026 1024572 1025642 + hypothetical protein gene gene1025 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01026 S101447_01027 S101447_01027 S101447_01027 1025718 1026488 - hypothetical protein gene gene1026 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01027 S101447_01028 S101447_01028 fcbD fcbD 1026485 1028035 - Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase KEGG: fbl:Fbal_0446 chondroitin synthase gene gene1027 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01028 S101447_01029 S101447_01029 S101447_01029 1028366 1030216 + hypothetical protein gene gene1028 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01029 S101447_01030 S101447_01030 S101447_01030 1030299 1030781 - Serralysin KEGG: ead:OV14_a0788 serralysin gene gene1029 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01030 S101447_01031 S101447_01031 pqqL pqqL 1031012 1033756 - putative zinc protease Hydrolase%3B Metal-binding%3B Metalloprotease%3B Protease%3B Zinc%3B Belongs to the peptidase M16 family%3B KEGG: apt:APA01_02420 zinc protease%3B Metalloendopeptidases gene gene1030 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01031 S101447_01032 S101447_01032 S101447_01032 1033800 1034465 - hypothetical protein gene gene1031 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01032 S101447_01033 S101447_01033 S101447_01033 1034682 1036928 - UvrABC system protein ATP-binding%3B Cytoplasm%3B DNA damage%3B DNA excision%3B DNA repair%3B Excision nuclease%3B Nucleotide-binding%3B SOS response%3B The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site%2C the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix%2C facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found%2C the DNA wraps around the other UvrB subunit that will check the other stand for damage%3B Belongs to the UvrB family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B Contains 1 UVR domain gene gene1032 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01033 S101447_01034 S101447_01034 S101447_01034 1036997 1037449 - hypothetical protein gene gene1033 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01034 S101447_01035 S101447_01035 S101447_01035 1037561 1038544 - General stress protein NADP%3B Oxidoreductase%3B Stress response%3B Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily%3B KEGG: gox:GOX1462 null%3B With NAD(+) or NADP(+) as acceptor gene gene1034 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01035 S101447_01036 S101447_01036 S101447_01036 1038713 1039174 + 8-oxo-dGTP diphosphatase KEGG: fve:101310598 8-oxo-dGTP diphosphatase gene gene1035 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01036 S101447_01037 S101447_01037 S101447_01037 1039190 1042126 - hypothetical protein gene gene1036 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01037 S101447_01038 S101447_01038 S101447_01038 1042254 1042769 - hypothetical protein gene gene1037 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01038 S101447_01039 S101447_01039 otsA otsA 1042766 1044112 - Alpha%2Calpha-trehalose-phosphate synthase (UDP-forming) Glycosyltransferase%3B Transferase%3B Catalyzes the transfer of glucose from UDP-glucose to glucose-6-phosphate to form alpha%2Calpha-1%2C1 trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor (By similarity)%3B Belongs to the glycosyltransferase 20 family%3B KEGG: eco:b1896 trehalose 6-phosphate synthase gene gene1038 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01039 S101447_01040 S101447_01040 otsB otsB 1044116 1044859 - Trehalose-phosphatase Carbohydrate metabolism%3B Glycosyltransferase%3B Transferase%3B Synthesizes trehalose 6-phosphate%2C the precursor for the production of trehalose%2C the main carbohydrate storage reserve of the dormant spore. Trehalose accumulates in both prestalk and prespore cells and then is rapidly metabolized during terminal differentiation of stalk cells%2C while being stored in spores%2C where it serves as the principal energy and carbon source for germination%3B In the N-terminal sectio%3B belongs to the glycosyltransferase 20 family%3B In the C-terminal sectio%3B belongs to the trehalose phosphatase family%3B KEGG: apt:APA01_02330 trehalose 6-phosphate phosphatase gene gene1039 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01040 S101447_01041 S101447_01041 S101447_01041 1045044 1045631 - hypothetical protein gene gene1040 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01041 S101447_01042 S101447_01042 S101447_01042 1045628 1045849 - hypothetical protein gene gene1041 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01042 S101447_01043 S101447_01043 S101447_01043 1045900 1046445 - hypothetical protein gene gene1042 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01043 S101447_01044 S101447_01044 S101447_01044 1046494 1046862 - hypothetical protein gene gene1043 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01044 S101447_01045 S101447_01045 S101447_01045 1047110 1048627 + Ribonucleoside-diphosphate reductase Cobalamin%3B Cobalt%3B Disulfide bond%3B DNA synthesis%3B Nucleotide-binding%3B Oxidoreductase%3B Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen (By similarity)%3B Belongs to the ribonucleoside diphosphate reductase class-2 family%3B KEGG: txi:TH3_07670 ribonucleoside-diphosphate reductase alpha chain gene gene1044 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01045 S101447_01046 S101447_01046 wrbA wrbA 1048707 1049168 + NAD(P)H dehydrogenase (quinone) Cytoplasm%3B KEGG: myr:MYRA21_1134 NAD(P)H dehydrogenase (quinone) gene gene1045 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01046 S101447_01047 S101447_01047 S101447_01047 1049188 1050336 + hypothetical protein gene gene1046 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01047 S101447_01048 S101447_01048 folD folD 1050455 1051369 + Methylenetetrahydrofolate dehydrogenase (NADP(+)) Amino-acid biosynthesis%3B Histidine biosynthesis%3B Hydrolase%3B Methionine biosynthesis%3B Multifunctional enzyme%3B NADP%3B One-carbon metabolism%3B Oxidoreductase%3B Purine biosynthesis%3B Catalyzes the oxidation of 5%2C10- methylenetetrahydrofolate to 5%2C10-methenyltetrahydrofolate and then the hydrolysis of 5%2C10-methenyltetrahydrofolate to 10- formyltetrahydrofolate%3B Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family%3B KEGG: apt:APA01_02250 methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase gene gene1047 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01048 S101447_01049 S101447_01049 metF metF 1051366 1052115 + Methylenetetrahydrofolate reductase (NAD(P)H) KEGG: apt:APA01_02240 methylenetetrahydrofolate reductase (NADPH) gene gene1048 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01049 S101447_01050 S101447_01050 S101447_01050 1052176 1054278 + hypothetical protein gene gene1049 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01050 S101447_01051 S101447_01051 S101447_01051 1054344 1054841 - UPF0098 protein YbhB Cytoplasm%3B Belongs to the UPF0098 family gene gene1050 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01051 S101447_01052 S101447_01052 S101447_01052 1054861 1055073 - hypothetical protein gene gene1051 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01052 S101447_01053 S101447_01053 queA queA 1055243 1056325 + S-adenosylmethionine:tRNA ribosyltransferase-isomerase Cytoplasm%3B Queuosine biosynthesis%3B S-adenosyl-L-methionine%3B Transferase%3B Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)%3B Belongs to the QueA family%3B KEGG: apt:APA01_02200 S-adenosylmethionine:tRNA ribosyltransferase-isomerase gene gene1052 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01053 S101447_01054 S101447_01054 S101447_01054 1056322 1057482 + tRNA-guanine(34) transglycosylase Glycosyltransferase%3B Metal-binding%3B Queuosine biosynthesis%3B Transferase%3B tRNA processing%3B Zinc%3B Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp%2C -Asn%2C -His and -Tyr). After this exchange%2C a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine%2C resulting in the hypermodified nucleoside queuosine (Q) (7-(((4%2C5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)%3B Belongs to the queuine tRNA-ribosyltransferase family%3B KEGG: apt:APA01_02190 queuine tRNA-ribosyltransferase gene gene1053 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01054 S101447_01055 S101447_01055 queG queG 1057495 1058595 + Epoxyqueuosine reductase 4Fe-4S%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase%3B Queuosine biosynthesis%3B tRNA processing%3B Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q)%2C which is a hypermodified base found in the wobble positions of tRNA(Asp)%2C tRNA(Asn)%2C tRNA(His) and tRNA(Tyr)%3B Belongs to the QueG family%3B Contains 1 4Fe-4S ferredoxin-type domain%3B KEGG: tkm:TK90_0490 epoxyqueuosine reductase gene gene1054 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01055 S101447_01056 S101447_01056 S101447_01056 1058592 1058837 + hypothetical protein gene gene1055 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01056 S101447_01057 S101447_01057 S101447_01057 1058917 1059744 + DnaJ-like protein DjlA Cell inner membrane%3B Cell membrane%3B Chaperone%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon%2C involved in the synthesis of a colanic acid polysaccharide capsule%2C possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host%3B Contains 1 J domain gene gene1056 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01057 S101447_01058 S101447_01058 S101447_01058 1059989 1060837 + putative phospholipid-binding lipoprotein MlaA Cell outer membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane%3B Belongs to the MlaA family gene gene1057 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01058 S101447_01059 S101447_01059 S101447_01059 1060865 1061491 + hypothetical protein gene gene1058 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01059 S101447_01060 S101447_01060 S101447_01060 1061549 1062052 - hypothetical protein gene gene1059 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01060 S101447_01061 S101447_01061 ugpC ugpC 1062175 1063854 - Glycerol-3-phosphate-transporting ATPase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Sugar transport%3B Transport%3B Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. sn- glycerol-3-phosphate importer (TC 3. A. 1. 1. 3) family%3B Contains 1 ABC transporter domain%3B KEGG: rpd:RPD_0183 sn-glycerol 3-phosphate transport system ATP-binding protein gene gene1060 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01061 S101447_01062 S101447_01062 S101447_01062 1063934 1064007 - tRNA-Met tRNA gene1061 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01062 S101447_01063 S101447_01063 S101447_01063 1064164 1064691 + Inorganic diphosphatase Cytoplasm%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Belongs to the PPase family%3B KEGG: gox:GOX0757 inorganic pyrophosphatase gene gene1062 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01063 S101447_01064 S101447_01064 dopA dopA 1064850 1065665 + 4%2C5-DOPA dioxygenase extradiol Cytoplasm%3B Dioxygenase%3B Metal-binding%3B Oxidoreductase%3B Zinc%3B In vitro%2C opens the cyclic ring of dihydroxy- phenylalanine (DOPA) between carbons 4 and 5%2C thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown%3B Belongs to the DODA-type extradiol aromatic ring- opening dioxygenase family%3B KEGG: smo:SELMODRAFT_123722 4%2C5-DOPA dioxygenase extradiol%3B With incorporation of two atoms of oxygen gene gene1063 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01064 S101447_01065 S101447_01065 S101447_01065 1065742 1066077 + hypothetical protein gene gene1064 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01065 S101447_01066 S101447_01066 S101447_01066 1066600 1067208 + UPF0312 protein Periplasm%3B Signal%3B Belongs to the UPF0312 family. Type 1 subfamily gene gene1065 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01066 S101447_01067 S101447_01067 S101447_01067 1067358 1067434 + tRNA-Asp tRNA gene1066 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01067 S101447_01068 S101447_01068 S101447_01068 1067534 1068061 - Alkyl hydroperoxide reductase AhpD Antioxidant%3B Disulfide bond%3B Oxidoreductase%3B Peroxidase%3B Redox-active center%3B Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity%3B Belongs to the AhpD family gene gene1067 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01068 S101447_01069 S101447_01069 prdX prdX 1068264 1068806 - Peroxiredoxin Acetylation%3B Antioxidant%3B Disulfide bond%3B Mitochondrion%3B Oxidoreductase%3B Peroxidase%3B Phosphoprotein%3B Redox-active center%3B Transit peptide%3B Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Belongs to the AhpC/TSA family%3B Contains 1 thioredoxin domain%3B KEGG: gxy:GLX_20820 peroxiredoxin (alkyl hydroperoxide reductase subunit C) gene gene1068 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01069 S101447_01070 S101447_01070 S101447_01070 1068987 1069949 + HTH-type transcriptional regulator EstR DNA-binding%3B Transcription%3B Transcription regulation%3B Transcriptional regulator of the esterase operon. Contains 1 HTH lysR-type DNA-binding domain gene gene1069 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01070 S101447_01071 S101447_01071 S101447_01071 1070058 1070183 + 50S ribosomal protein L36 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein L36P family gene gene1070 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01071 S101447_01072 S101447_01072 S101447_01072 1070188 1070877 + TPR repeat-containing protein Repeat%3B Signal%3B TPR repeat%3B Contains 3 TPR repeats gene gene1071 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01072 S101447_01073 S101447_01073 tyrC tyrC 1070893 1071774 - Arogenate dehydrogenase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B NAD%3B Oxidoreductase%3B Tyrosine biosynthesis%3B Is competent to function as either prephenate dehydrogenase or as arogenate dehydrogenase. Contains 1 prephenate/arogenate dehydrogenase domain%3B KEGG: goh:B932_2751 cyclohexadieny/prephenate dehydrogenase gene gene1072 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01073 S101447_01074 S101447_01074 S101447_01074 1071782 1072873 - hypothetical protein gene gene1073 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01074 S101447_01075 S101447_01075 S101447_01075 1073067 1074062 + Dihydrokaempferol 4-reductase Flavonoid biosynthesis%3B NADP%3B Oxidoreductase%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily%3B KEGG: apt:APA01_02000 dihydroflavonol-4-reductase gene gene1074 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01075 S101447_01076 S101447_01076 S101447_01076 1074073 1075269 + hypothetical protein gene gene1075 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01076 S101447_01077 S101447_01077 S101447_01077 1075383 1076243 + Squalene synthase Isoprene biosynthesis%3B Plasmid%3B Probably part of the operon y4aABCD involved in the synthesis of an isoprenoid compound. Belongs to the phytoene/squalene synthase family%3B KEGG: gbe:GbCGDNIH1_1980 farnesyl-diphosphate farnesyltransferase gene gene1076 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01077 S101447_01078 S101447_01078 crtB crtB 1076321 1077220 + 15-cis-phytoene synthase Carotenoid biosynthesis%3B Isoprene biosynthesis%3B Multifunctional enzyme%3B Plasmid%3B Transferase%3B Catalyzes the reaction from prephytoene diphosphate to phytoene. Probably part of an operon y4aABCD involved in the synthesis of an isoprenoid compound. Belongs to the phytoene/squalene synthase family%3B KEGG: apt:APA01_01970 phytoene synthase gene gene1077 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01078 S101447_01079 S101447_01079 crtQ crtQ 1077242 1078540 + 9%2C9'-di-cis-zeta-carotene desaturase FAD%3B Flavoprotein%3B Isoprene biosynthesis%3B Oxidoreductase%3B Plasmid%3B Possible flavoprotein oxidoreductase. Probably part of an operon y4aABCD involved in the synthesis of an isoprenoid compound. To phytoene dehydrogenase and to amine oxidase%3B KEGG: aba:Acid345_1747 zeta-carotene desaturase gene gene1078 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01079 S101447_01080 S101447_01080 S101447_01080 1078608 1080578 + Squalene--hopene cyclase Cell membrane%3B Isomerase%3B Lyase%3B Membrane%3B Repeat%3B Catalyzes the cyclization of squalene into hopene. Belongs to the terpene cyclase/mutase family%3B Contains 4 PFTB repeats%3B KEGG: apt:APA01_01950 squalene-hopene/tetraprenyl-beta-curcumene cyclase gene gene1079 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01080 S101447_01081 S101447_01081 mtnN mtnN 1080583 1081293 + Adenosylhomocysteine nucleosidase KEGG: gbe:GbCGDNIH1_2407 adenosylhomocysteine nucleosidase gene gene1080 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01081 S101447_01082 S101447_01082 S101447_01082 1081301 1081519 - hypothetical protein gene gene1081 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01082 S101447_01083 S101447_01083 S101447_01083 1081605 1083122 - Cation efflux system protein CusC Cell outer membrane%3B Ion transport%3B Lipoprotein%3B Membrane%3B Palmitate%3B Porin%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver (By similarity)%3B Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene1082 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01083 S101447_01084 S101447_01084 S101447_01084 1083144 1084055 - p-hydroxybenzoic acid efflux pump subunit AaeA Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Forms an efflux pump with AaeB%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene1083 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01084 S101447_01085 S101447_01085 S101447_01085 1084299 1084793 - Transcriptional regulator SlyA Activator%3B DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Transcription regulator that can specifically activate or repress expression of target genes%3B Belongs to the SlyA family%3B Contains 1 HTH marR-type DNA-binding domain gene gene1084 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01085 S101447_01086 S101447_01086 S101447_01086 1084927 1085352 - hypothetical protein gene gene1085 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01086 S101447_01087 S101447_01087 S101447_01087 1085392 1085694 - hypothetical protein gene gene1086 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01087 S101447_01088 S101447_01088 modC modC 1085768 1086883 + Molybdate-transporting ATPase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Nucleotide-binding%3B Transport%3B Most probably involved%2C with PEB1%2C in a binding-protein- dependent transport system for an amino acid. Probably responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B KEGG: mey:TM49_15680 molybdate transport system ATP-binding protein gene gene1087 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01088 S101447_01089 S101447_01089 S101447_01089 1086919 1088028 + hypothetical protein gene gene1088 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01089 S101447_01090 S101447_01090 S101447_01090 1088010 1088447 + hypothetical protein gene gene1089 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01090 S101447_01091 S101447_01091 S101447_01091 1088444 1088899 + UPF0260 protein Belongs to the UPF0260 family gene gene1090 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01091 S101447_01092 S101447_01092 S101447_01092 1088965 1089642 + hypothetical protein gene gene1091 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01092 S101447_01093 S101447_01093 S101447_01093 1089714 1089800 + tRNA-Leu tRNA gene1092 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01093 S101447_01094 S101447_01094 S101447_01094 1089890 1091263 + hypothetical protein gene gene1093 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01094 S101447_01095 S101447_01095 S101447_01095 1091502 1096814 + hypothetical protein gene gene1094 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01095 S101447_01096 S101447_01096 S101447_01096 1096943 1097341 - Protein kinase doc ATP-binding%3B DNA-binding%3B Kinase%3B Nucleotide-binding%3B Repressor%3B Toxin%3B Transcription%3B Transcription regulation%3B Transferase%3B Translation regulation%3B Toxic component of a toxin-antitoxin (TA) module. Phosphorylates EF-Tu on 'Thr-383' in vitr%3B can use ATP or GTP. Also dephosphorylates in the presence of ADP or GDP. Can only phosphorylate before the ternary aminoacyl-tRNA EF-Tu-GTP complex is forme%3B interaction with cognate antitoxin phd prevents phosphorylation and dephosphorylation of EF-Tu. Overexpression results in inhibition of growth in liquid cultures and a decrease in colony formation by inhibiting translation%2C stabilizing mRNA and polysome%3B these effects are overcome by concomitant expression of antitoxin phd. Binds 70S ribosomes and the 30S ribosomal subunits%2C the binding site is the same as for the antibiotic hygromycin B. Bacteriophage P1 lysogenizes bacteria as a low-copy number plasmi%3B doc and phd proteins function in unison to stabilize plasmid number by inducing a lethal response to P1 plasmid prophage loss. Overexpression of doc can induce the mRNA interferase activity of host RelE in vivo. Antitoxin phd binds to its own promoter repressing its expressio%3B toxin doc acts as a corepressor or derepressor depending on the ratio%2C repressing or inducing expression. Contains 1 fido domain gene gene1095 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01096 S101447_01097 S101447_01097 S101447_01097 1097341 1097568 - hypothetical protein gene gene1096 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01097 S101447_01098 S101447_01098 S101447_01098 1097908 1099536 + hypothetical protein gene gene1097 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01098 S101447_01099 S101447_01099 S101447_01099 1100046 1100843 + hypothetical protein gene gene1098 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01099 S101447_01100 S101447_01100 S101447_01100 1100853 1101368 - hypothetical protein gene gene1099 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01100 S101447_01101 S101447_01101 S101447_01101 1101412 1101507 + hypothetical protein gene gene1100 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01101 S101447_01102 S101447_01102 S101447_01102 1101582 1101677 + hypothetical protein gene gene1101 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01102 S101447_01103 S101447_01103 S101447_01103 1101655 1102662 + L-galactose 1-dehydrogenase Auxin signaling pathway%3B NADP%3B Oxidoreductase%3B Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily%3B KEGG: gmx:100809400 L-galactose dehydrogenase gene gene1102 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01103 S101447_01104 S101447_01104 S101447_01104 1102845 1103057 - hypothetical protein gene gene1103 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01104 S101447_01105 S101447_01105 S101447_01105 1103069 1103338 - hypothetical protein gene gene1104 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01105 S101447_01106 S101447_01106 S101447_01106 1103607 1103990 - hypothetical protein gene gene1105 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01106 S101447_01107 S101447_01107 S101447_01107 1103962 1104297 - hypothetical protein gene gene1106 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01107 S101447_01108 S101447_01108 S101447_01108 1104335 1104925 - hypothetical protein gene gene1107 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01108 S101447_01109 S101447_01109 S101447_01109 1105384 1105818 - hypothetical protein gene gene1108 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01109 S101447_01110 S101447_01110 S101447_01110 1105854 1106066 + hypothetical protein gene gene1109 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01110 S101447_01111 S101447_01111 S101447_01111 1105984 1106418 - hypothetical protein gene gene1110 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01111 S101447_01112 S101447_01112 S101447_01112 1106454 1106666 + hypothetical protein gene gene1111 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01112 S101447_01113 S101447_01113 S101447_01113 1106584 1107018 - hypothetical protein gene gene1112 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01113 S101447_01114 S101447_01114 S101447_01114 1107054 1107230 + hypothetical protein gene gene1113 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01114 S101447_01115 S101447_01115 S101447_01115 1107468 1107761 - putative HTH-type transcriptional regulator DNA-binding%3B Transcription%3B Transcription regulation%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene1114 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01115 S101447_01116 S101447_01116 S101447_01116 1108402 1109145 - Aliphatic sulfonates import ATP-binding protein SsuB ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3. A. 1. 17. 2) family%3B Contains 1 ABC transporter domain gene gene1115 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01116 S101447_01117 S101447_01117 S101447_01117 1109135 1109881 - Monosaccharide-transporting ATPase ATP-binding%3B Cell membrane%3B Hydrolase%3B Ion transport%3B Membrane%3B Nucleotide-binding%3B Transport%3B Zinc%3B Zinc transport%3B Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Zinc importer (TC 3. A. 1. 15. 5) family%3B Contains 1 ABC transporter domain%3B KEGG: pam:PANA_1790 simple sugar transport system ATP-binding protein gene gene1116 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01117 S101447_01118 S101447_01118 S101447_01118 1109893 1111008 - hypothetical protein gene gene1117 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01118 S101447_01119 S101447_01119 S101447_01119 1111019 1111945 - High-affinity branched-chain amino acid transport system permease protein BraD Amino-acid transport%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Component of the high affinity leucine%2C isoleucine%2C valine%2C transport system (LIV-I)%2C which is operative without Na(+) and is specific for alanine and threonine%2C in addition to branched-chain amino acids. Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily gene gene1118 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01119 S101447_01120 S101447_01120 S101447_01120 1112000 1113265 - Aliphatic amidase expression-regulating protein Kinase%3B Repressor%3B Transferase. gene gene1119 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01120 S101447_01121 S101447_01121 S101447_01121 1113476 1116820 + Sensor histidine kinase AruS ATP-binding%3B Cell membrane%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system%3B Member of the two-component regulatory system AruS/AruR%2C which is involved in the regulation of the arginine transaminase (ATA) pathway in response to exogeneous L-arginine. Probably functions as a sensor kinase that phosphorylates AruR%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 response regulatory domain%3B KEGG: aci:ACIAD2501 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene1120 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01121 S101447_01122 S101447_01122 rcsC rcsC 1116817 1117716 + Histidine kinase ATP-binding%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Receptor%3B Repeat%3B Transducer%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system%3B Acts in a signal transduction pathway that regulates the slug versus culmination choice. Believed to be the first component of a phosphorelay that couples the sensing of ammonia to the modulation of PKA activity and hence activates culmination and spore germination. Ammonium transporters amtA and amtC are thought to respectively activate and inhibit dhkC phosphorelay. This protein probably undergoes an ATP-dependent autophosphorylation at conserved His residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain%3B Contains 1 histidine kinase domain%3B Contains 2 response regulatory domains%3B KEGG: yen:YE1396 two-component system%2C NarL family%2C capsular synthesis sensor histidine kinase RcsC gene gene1121 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01122 S101447_01123 S101447_01123 S101447_01123 1117769 1118776 - Formamidase Hydrolase%3B Is an aliphatic amidase with a restricted substrate specificity%2C as it only hydrolyzes formamide%3B Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family%3B Contains 1 CN hydrolase domain%3B KEGG: plu:plu3213 formamidase gene gene1122 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01123 S101447_01124 S101447_01124 S101447_01124 1119198 1120400 + hypothetical protein gene gene1123 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01124 S101447_01125 S101447_01125 S101447_01125 1120466 1120909 + hypothetical protein gene gene1124 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01125 S101447_01126 S101447_01126 S101447_01126 1121631 1122902 + Glycosyltransferase TibC Glycosyltransferase%3B Transferase%3B Glycosylates the TibA adhesin%3B KEGG: gox:GOX0897 null%3B Hexosyltransferases gene gene1125 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01126 S101447_01127 S101447_01127 S101447_01127 1122908 1126060 + Adhesin/invasin TibA autotransporter Cell adhesion%3B Cell outer membrane%3B Glycoprotein%3B Membrane%3B Periplasm%3B Repeat%3B Secreted%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Virulence%3B Mediates both adhesion to and invasion of human intestine epithelial cells. Also mediates bacterial cell aggregation via intercellular TibA-TibA interaction. Enhances biofilm formation%3B Contains 1 autotransporter (TC 1. B. 12) domain gene gene1126 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01127 S101447_01128 S101447_01128 S101447_01128 1126345 1128699 + Ferrichrome receptor FcuA Cell outer membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Receptor for the hydroxamate siderophore%2C ferrichrome. Binds also to most other ferrichrome derivatives except enantio ferrichrome and ferric rhodotorulate. Belongs to the TonB-dependent receptor family gene gene1127 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01128 S101447_01129 S101447_01129 S101447_01129 1128747 1129664 + hypothetical protein gene gene1128 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01129 S101447_01130 S101447_01130 S101447_01130 1129959 1130165 + Cold shock-like protein 7.0 Activator%3B Cytoplasm%3B DNA-binding%3B Stress response%3B Transcription%3B Transcription regulation%3B Contains 1 CSD (cold-shock) domain gene gene1129 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01130 S101447_01131 S101447_01131 S101447_01131 1130245 1131729 - Outer membrane protein OprM Antibiotic resistance%3B Cell outer membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over- expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pum%3B the antibiotics exported are those exported by the intact MexCD pump%2C showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the MexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane. The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP)%2C showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter. Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene1130 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01131 S101447_01132 S101447_01132 S101447_01132 1131734 1134889 - Antibiotic efflux pump membrane transporter ArpB Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B The inner membrane transporter component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin%2C chloramphenicol%2C erythromycin%2C novobiocin%2C streptomycin and tetracycline. Is not involved in organic solvent efflux. Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene1131 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01132 S101447_01133 S101447_01133 S101447_01133 1134895 1136085 - Multidrug export protein AcrE Cell inner membrane%3B Cell membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Transport%3B Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene1132 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01133 S101447_01134 S101447_01134 S101447_01134 1136585 1137937 - putative transporter Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Probable amino-acid or metabolite transport protein. Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene1133 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01134 S101447_01135 S101447_01135 eutC eutC 1137970 1138755 - Ethanolamine ammonia-lyase Cobalamin%3B Cobalt%3B Lyase%3B Belongs to the EutC family%3B KEGG: apt:APA01_01380 ethanolamine ammonia-lyase small subunit%3B overlaps another CDS with the same product name gene gene1134 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01135 S101447_01136 S101447_01136 eutB eutB 1138752 1140140 - Ethanolamine ammonia-lyase Cobalt%3B Lyase%3B KEGG: apt:APA01_01370 ethanolamine ammonia-lyase large subunit%3B overlaps another CDS with the same product name gene gene1135 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01136 S101447_01137 S101447_01137 S101447_01137 1140326 1141378 + Ornithine utilization regulator Activator%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Probably activates the ArgJ gene that encodes ornithine acetyltransferase. Binds to its own promoter-operator region. Probably binds ornithine. Contains 1 HTH araC/xylS-type DNA-binding domain gene gene1136 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01137 S101447_01138 S101447_01138 S101447_01138 1141408 1142442 - Thiosulfate-binding protein Periplasm%3B Signal%3B Sulfate transport%3B Transport%3B Part of the ABC transporter complex CysAWTP (TC 3. A. 1. 6. 1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport. Belongs to the prokaryotic sulfate-binding protein family gene gene1137 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01138 S101447_01139 S101447_01139 S101447_01139 1142469 1144139 - hypothetical protein gene gene1138 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01139 S101447_01140 S101447_01140 S101447_01140 1144359 1144568 - hypothetical protein gene gene1139 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01140 S101447_01141 S101447_01141 S101447_01141 1145119 1145958 + Sulfate transport system permease protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Sulfate transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the ABC transporter complex CysAWTP (TC 3. A. 1. 6. 1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain%3B overlaps another CDS with the same product name gene gene1140 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01141 S101447_01142 S101447_01142 S101447_01142 1145955 1146773 + Sulfate transport system permease protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Sulfate transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the ABC transporter complex CysAWTP (TC 3. A. 1. 6. 1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain%3B overlaps another CDS with the same product name gene gene1141 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01142 S101447_01143 S101447_01143 cysA cysA 1146770 1147807 + Sulfate-transporting ATPase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B KEGG: apt:APA01_01280 sulfate transport system ATP-binding protein gene gene1142 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01143 S101447_01144 S101447_01144 S101447_01144 1147978 1149459 + L-asparagine permease Amino-acid transport%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2. A. 3. 1) family gene gene1143 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01144 S101447_01145 S101447_01145 S101447_01145 1149607 1150212 + hypothetical protein gene gene1144 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01145 S101447_01146 S101447_01146 S101447_01146 1150297 1150806 - hypothetical protein gene gene1145 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01146 S101447_01147 S101447_01147 S101447_01147 1151201 1152199 + Adenosine kinase Kinase%3B Transferase%3B Belongs to the carbohydrate kinase PfkB family%3B KEGG: bra:BRADO0031 adenosine kinase gene gene1146 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01147 S101447_01148 S101447_01148 S101447_01148 1152229 1153437 - Ribonuclease D Cytoplasm%3B Exonuclease%3B Hydrolase%3B Nuclease%3B tRNA processing%3B Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides%3B Belongs to the RNase D family%3B Contains 1 3'-5' exonuclease domain%3B Contains 1 HRDC domain%3B KEGG: apt:APA01_01230 ribonuclease D gene gene1147 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01148 S101447_01149 S101447_01149 queF queF 1153557 1154027 + PreQ(1) synthase Cytoplasm%3B NADP%3B Oxidoreductase%3B Queuosine biosynthesis%3B Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)%3B Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily%3B KEGG: sgg:SGGBAA2069_c12860 7-cyano-7-deazaguanine reductase gene gene1148 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01149 S101447_01150 S101447_01150 S101447_01150 1154085 1154495 - ATP synthase epsilon chain ATP synthesis%3B Cell inner membrane%3B Cell membrane%3B CF(1)%3B Hydrogen ion transport%3B Ion transport%3B Membrane%3B Transport%3B Produces ATP from ADP in the presence of a proton gradient across the membrane%3B Belongs to the ATPase epsilon chain family gene gene1149 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01150 S101447_01151 S101447_01151 atpD atpD 1154523 1155995 - H(+)-transporting two-sector ATPase ATP synthesis%3B ATP-binding%3B Cell inner membrane%3B Cell membrane%3B CF(1)%3B Hydrogen ion transport%3B Hydrolase%3B Ion transport%3B Membrane%3B Nucleotide-binding%3B Transport%3B Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: apt:APA01_01200 F-type H+-transporting ATPase subunit beta gene gene1150 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01151 S101447_01152 S101447_01152 S101447_01152 1156027 1156917 - ATP synthase gamma chain ATP synthesis%3B Cell inner membrane%3B Cell membrane%3B CF(1)%3B Hydrogen ion transport%3B Ion transport%3B Membrane%3B Transport%3B Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex%3B Belongs to the ATPase gamma chain family gene gene1151 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01152 S101447_01153 S101447_01153 atpA atpA 1156935 1158470 - H(+)-transporting two-sector ATPase ATP synthesis%3B ATP-binding%3B CF(1)%3B Hydrogen ion transport%3B Hydrolase%3B Ion transport%3B Membrane%3B Nucleotide-binding%3B Thylakoid%3B Transport%3B Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: hfe:HFELIS_14640 F-type H+-transporting ATPase subunit alpha gene gene1152 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01153 S101447_01154 S101447_01154 S101447_01154 1158470 1159054 - ATP synthase subunit O%2C mitochondrial ATP synthesis%3B Hydrogen ion transport%3B Ion transport%3B Membrane%3B Mitochondrion%3B Mitochondrion inner membrane%3B Transit peptide%3B Transport%3B Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains%2C F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk%2C which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Belongs to the ATPase delta chain family gene gene1153 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01154 S101447_01155 S101447_01155 S101447_01155 1159379 1159452 - tRNA-Gly tRNA gene1154 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01155 S101447_01156 S101447_01156 S101447_01156 1159677 1159753 + tRNA-Trp tRNA gene1155 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01156 S101447_01157 S101447_01157 S101447_01157 1159897 1160091 + hypothetical protein gene gene1156 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01157 S101447_01158 S101447_01158 S101447_01158 1160096 1160626 + Transcription termination/antitermination protein NusG Transcription%3B Transcription antitermination%3B Transcription regulation%3B Transcription termination%3B Participates in transcription elongation%2C termination and antitermination. In the absence of Rho%2C increases the rate of transcription elongation by the RNA polymerase (RNAP)%2C probably by partially suppressing pausing. In the presence of Rho%2C modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination%3B Belongs to the NusG family%3B Contains 1 KOW domain gene gene1157 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01158 S101447_01159 S101447_01159 maeB maeB 1160775 1162409 + Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Metal-binding%3B NAD%3B Oxidoreductase%3B Belongs to the malic enzymes family%3B KEGG: apt:APA01_01110 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) gene gene1158 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01159 S101447_01160 S101447_01160 apeH apeH 1162464 1164491 - Acylaminoacyl-peptidase Aminopeptidase%3B Hydrolase%3B Protease%3B Serine protease%3B Signal%3B Exopeptidase that catalyzes the removal of dipeptide units (NH2-P2-P1- or -P1'-P2'-COOH) from the free amino or carboxy termini. Prefers substrates composed of bulky%2C hydrophobic amino acids at P1 and P1' positions. Has endopeptidase activity on N- terminally blocked peptide derivatives which contain aromatic amino acid residue at the P1 position. Exopeptidase activity is much higher than its endopeptidase activity%3B Belongs to the peptidase S9 family%3B KEGG: gka:GK0961 acylaminoacyl-peptidase gene gene1159 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01160 S101447_01161 S101447_01161 S101447_01161 1164680 1165264 + putative membrane protein YkoX Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the DedA family gene gene1160 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01161 S101447_01162 S101447_01162 S101447_01162 1165261 1166211 + Tropinone reductase I Oxidoreductase%3B Signal%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: psu:Psesu_2758 tropinone reductase I gene gene1161 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01162 S101447_01163 S101447_01163 suv3 suv3 1166267 1168615 - RNA helicase ATP-binding%3B Helicase%3B Hydrolase%3B Mitochondrion%3B Nucleotide-binding%3B Nucleus%3B Transit peptide%3B ATPase and DNA/RNA helicase able to unwind DNA/DNA%2C DNA/RNA and RNA/RNA duplexes in the 5'-3' direction%3B Belongs to the helicase family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: apt:APA01_01070 ATP-dependent RNA helicase SUPV3L1/SUV3 gene gene1162 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01163 S101447_01164 S101447_01164 S101447_01164 1168934 1169830 + Ferredoxin--NADP(+) reductase FAD%3B Flavoprotein%3B NADP%3B Oxidoreductase%3B Belongs to the ferredoxin--NADP reductase type 1 family%3B Contains 1 FAD-binding FR-type domain%3B KEGG: apt:APA01_01060 ferredoxin--NADP+ reductase gene gene1163 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01164 S101447_01165 S101447_01165 sthA sthA 1169891 1171288 + NAD(P)(+) transhydrogenase (Si-specific) Cytoplasm%3B Disulfide bond%3B FAD%3B Flavoprotein%3B Glycolysis%3B NAD%3B Oxidoreductase%3B Redox-active center%3B Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: ftu:FTT_0684c NAD(P) transhydrogenase gene gene1164 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01165 S101447_01166 S101447_01166 S101447_01166 1171295 1172659 + Dihydroorotase Hydrolase%3B Metal-binding%3B Pyrimidine biosynthesis%3B Zinc%3B Belongs to the DHOase family. Type 2 subfamily%3B KEGG: apt:APA01_01040 dihydroorotase gene gene1165 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01166 S101447_01167 S101447_01167 S101447_01167 1172754 1173218 - hypothetical protein gene gene1166 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01167 S101447_01168 S101447_01168 wbpE wbpE 1173235 1174371 - UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase Antibiotic biosynthesis%3B Pyridoxal phosphate%3B Transferase%3B Involved in the biosynthesis of dTDP-alpha-D-desosamine%2C a sugar found in several bacterial macrolide antibiotics. Catalyzes the reversible transfer of the amino group from L- glutamate to the C-3 position of dTDP-3-keto-4%2C6-deoxyglucose to yield dTDP-3-amino-3%2C4%2C6-trideoxyglucose%3B Belongs to the degT/dnrJ/eryC1 family%3B KEGG: prw:PsycPRwf_0245 UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase gene gene1167 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01168 S101447_01169 S101447_01169 S101447_01169 1174368 1176398 - Capsular polysaccharide biosynthesis protein CapD Capsule biogenesis/degradation%3B Cell membrane%3B Exopolysaccharide synthesis%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Required for the biosynthesis of type 1 capsular polysaccharide. Belongs to the polysaccharide synthase family gene gene1168 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01169 S101447_01170 S101447_01170 wecA wecA 1176464 1177489 + UDP-N-acetylglucosamine--undecaprenyl-phosphateN-acetylglucosaminephosphotransferase Cell membrane%3B Cell wall biogenesis/degradation%3B Glycosyltransferase%3B Magnesium%3B Manganese%3B Membrane%3B Teichoic acid biosynthesis%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Catalyzes the formation of undecaprenyl-PP-N- acetylglucosamine. Involved in the synthesis of anionic cell-wall polymers as it mediates the initiation of the linkage unit formation that appears to be common to the two types of teichoic acids attached to the peptidoglycan of B. subtili%3B may also be involved in teichuronic acid biosynthesis (Probable)%3B Belongs to the glycosyltransferase 4 family%3B KEGG: gbh:GbCGDNIH2_0162 UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase gene gene1169 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01170 S101447_01171 S101447_01171 S101447_01171 1177499 1177945 - hypothetical protein gene gene1170 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01171 S101447_01172 S101447_01172 S101447_01172 1178088 1178504 - hypothetical protein gene gene1171 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01172 S101447_01173 S101447_01173 S101447_01173 1178660 1180096 - Leucyl aminopeptidase Aminopeptidase%3B Cytoplasm%3B Hydrolase%3B Manganese%3B Metal-binding%3B Protease%3B Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)%3B Belongs to the peptidase M17 family%3B KEGG: apt:APA01_00970 leucyl aminopeptidase gene gene1172 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01173 S101447_01174 S101447_01174 S101447_01174 1180208 1182796 + RNA helicase ATP-binding%3B Glycoprotein%3B Helicase%3B Hydrolase%3B Mitochondrion%3B Mitochondrion nucleoid%3B Nucleotide-binding%3B Nucleus%3B Transit peptide%3B Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex%2C that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase%2C able to unwind double-stranded (ds) DNA and RNA%2C and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondri%3B regulates the stability of mature mRNAs%2C the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates%3B Belongs to the helicase family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: apk:APA386B_1584 ATP-dependent RNA helicase SUPV3L1/SUV3 gene gene1173 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01174 S101447_01175 S101447_01175 S101447_01175 1182967 1183299 + Ferredoxin-1 3Fe-4S%3B 4Fe-4S%3B Electron transport%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Repeat%3B Transport%3B Contains 2 4Fe-4S ferredoxin-type domains gene gene1174 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01175 S101447_01176 S101447_01176 S101447_01176 1183558 1183890 - Cytochrome bo(3) ubiquinol oxidase subunit Cell inner membrane%3B Cell membrane%3B Electron transport%3B Membrane%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E. coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer%2C pumping 2 protons/electron (By similarity)%3B Belongs to the cytochrome c oxidase bacterial subunit 4 family%3B overlaps another CDS with the same product name gene gene1175 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01176 S101447_01177 S101447_01177 cyoC cyoC 1183890 1184495 - Cytochrome bo(3) ubiquinol oxidase subunit Cell membrane%3B Electron transport%3B Membrane%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E. coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer%2C pumping 2 protons/electron (By similarity)%3B Belongs to the cytochrome c oxidase subunit 3 family%3B KEGG: apt:APA01_00920 cytochrome o ubiquinol oxidase subunit III%3B With oxygen as acceptor%3B overlaps another CDS with the same product name gene gene1176 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01177 S101447_01178 S101447_01178 cyoB cyoB 1184497 1186488 - Cytochrome bo(3) ubiquinol oxidase subunit Cell inner membrane%3B Cell membrane%3B Copper%3B Electron transport%3B Heme%3B Hydrogen ion transport%3B Ion transport%3B Iron%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E. coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer%2C pumping 2 protons/electron (By similarity)%3B Belongs to the heme-copper respiratory oxidase family%3B KEGG: pae:PA1318 cytochrome o ubiquinol oxidase subunit I%3B With oxygen as acceptor gene gene1177 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01178 S101447_01179 S101447_01179 cyoA cyoA 1186494 1187420 - Ubiquinol oxidase subunit Cell membrane%3B Electron transport%3B Lipoprotein%3B Membrane%3B Oxidoreductase%3B Palmitate%3B Respiratory chain%3B Signal%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the cytochrome c oxidase subunit 2 family%3B KEGG: apt:APA01_00900 cytochrome o ubiquinol oxidase subunit II%3B With oxygen as acceptor gene gene1178 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01179 S101447_01180 S101447_01180 S101447_01180 1187848 1188015 - hypothetical protein gene gene1179 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01180 S101447_01181 S101447_01181 S101447_01181 1188032 1188808 - uncharacterized protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the BI1 family gene gene1180 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01181 S101447_01182 S101447_01182 S101447_01182 1188998 1189561 + hypothetical protein gene gene1181 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01182 S101447_01183 S101447_01183 exaA exaA 1189770 1191998 + Alcohol dehydrogenase (cytochrome c) Calcium%3B Disulfide bond%3B Heme%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Periplasm%3B PQQ%3B Signal%3B Catalyzes the oxidation of primary alcohols including methanol. Belongs to the bacterial PQQ dehydrogenase family%3B Contains 1 cytochrome c domain%3B KEGG: apt:APA01_00870 alcohol dehydrogenase (cytochrome c) gene gene1182 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01183 S101447_01184 S101447_01184 S101447_01184 1192051 1193469 + Nicotinate dehydrogenase (cytochrome) Cell membrane%3B Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Repeat%3B Signal%3B Transport%3B Dehydration of primary alcohols (exception: methanol). Contains 3 cytochrome c domains%3B KEGG: bju:BJ6T_60370 nicotinate dehydrogenase subunit B gene gene1183 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01184 S101447_01185 S101447_01185 S101447_01185 1193601 1194242 + uncharacterized protein gene gene1184 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01185 S101447_01186 S101447_01186 ttuD ttuD 1194249 1195547 - Hydroxypyruvate reductase NADP%3B Oxidoreductase%3B Plasmid%3B KEGG: apt:APA01_00840 hydroxypyruvate reductase gene gene1185 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01186 S101447_01187 S101447_01187 S101447_01187 1195608 1197833 - putative transporter Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the aromatic acid exporter ArAE (TC 2. A. 85) family gene gene1186 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01187 S101447_01188 S101447_01188 aprT aprT 1197987 1198520 - Adenine phosphoribosyltransferase Cytoplasm%3B Glycosyltransferase%3B Purine salvage%3B Transferase%3B Catalyzes a salvage reaction resulting in the formation of AMP%2C that is energically less costly than de novo synthesis%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family%3B KEGG: apt:APA01_00820 adenine phosphoribosyltransferase gene gene1187 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01188 S101447_01189 S101447_01189 cckA cckA 1198682 1200925 - Histidine kinase ATP-binding%3B Chromophore%3B Flavoprotein%3B FMN%3B Kinase%3B Nucleotide-binding%3B Phosphoprotein%3B Photoreceptor protein%3B Receptor%3B Sensory transduction%3B Transferase%3B Virulence%3B Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light%3B Contains 1 histidine kinase domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B Contains 1 response regulatory domain%3B KEGG: msc:BN69_0891 two-component system%2C cell cycle sensor histidine kinase and response regulator CckA gene gene1188 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01189 S101447_01190 S101447_01190 S101447_01190 1201029 1202291 - Bicyclomycin resistance protein Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase%3B Belongs to the major facilitator superfamily. Bcr/CmlA family gene gene1189 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01190 S101447_01191 S101447_01191 S101447_01191 1202452 1203144 - hypothetical protein gene gene1190 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01191 S101447_01192 S101447_01192 S101447_01192 1203216 1204295 + Heme A synthase Cell membrane%3B Heme biosynthesis%3B Membrane%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group%3B Belongs to the COX15/CtaA family. Type 2 subfamily gene gene1191 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01192 S101447_01193 S101447_01193 leuA leuA 1204591 1206180 + 2-isopropylmalate synthase Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Leucine biosynthesis%3B Transferase%3B Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)%3B Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily%3B KEGG: apt:APA01_00770 2-isopropylmalate synthase gene gene1192 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01193 S101447_01194 S101447_01194 S101447_01194 1206385 1207431 + MreB-like protein Belongs to the FtsA/MreB family gene gene1193 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01194 S101447_01195 S101447_01195 S101447_01195 1207527 1208441 + Cell shape-determining protein MreC Cell inner membrane%3B Cell membrane%3B Cell shape%3B Coiled coil%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Involved in formation and maintenance of cell shape%3B Belongs to the MreC family gene gene1194 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01195 S101447_01196 S101447_01196 S101447_01196 1208446 1209009 + hypothetical protein gene gene1195 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01196 S101447_01197 S101447_01197 S101447_01197 1209029 1210957 + Penicillin-binding protein Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Membrane%3B Multifunctional enzyme%3B Peptidoglycan synthesis%3B Transmembrane%3B Transmembrane helix%3B Cell wall formatio%3B PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates (By similarity)%3B Belongs to the transpeptidase family gene gene1196 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01197 S101447_01198 S101447_01198 S101447_01198 1210954 1212120 + Rod shape-determining protein RodA Cell inner membrane%3B Cell membrane%3B Cell shape%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Required for the maintenance of the rod cell shape. Required for the expression of the enzymatic activity of the penicillin-binding protein 2 (PBP2) (By similarity)%3B Belongs to the SEDS family. RodA subfamily gene gene1197 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01198 S101447_01199 S101447_01199 S101447_01199 1212208 1213437 - hypothetical protein gene gene1198 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01199 S101447_01200 S101447_01200 S101447_01200 1213450 1213890 - Biopolymer transport protein exbD1 Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates%3B Belongs to the ExbD/TolR family gene gene1199 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01200 S101447_01201 S101447_01201 S101447_01201 1213945 1214364 - Biopolymer transport protein ExbD Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates%3B Belongs to the ExbD/TolR family gene gene1200 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01201 S101447_01202 S101447_01202 S101447_01202 1214394 1215371 - Translation initiation factor IF-2 Cytoplasm%3B GTP-binding%3B Initiation factor%3B Nucleotide-binding%3B Protein biosynthesis%3B One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene1201 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01202 S101447_01203 S101447_01203 S101447_01203 1215480 1216199 - Protein enabled like protein Actin-binding%3B Alternative splicing%3B Cell junction%3B Cell projection%3B Coiled coil%3B Cytoplasm%3B Cytoskeleton%3B Developmental protein%3B Differentiation%3B Neurogenesis%3B Phosphoprotein%3B Repeat%3B SH3-binding%3B Synapse%3B Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation%3B Belongs to the Ena/VASP family%3B Contains 1 WH1 domain gene gene1202 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01203 S101447_01204 S101447_01204 S101447_01204 1216572 1217543 - Peptide chain release factor Cytoplasm%3B Methylation%3B Protein biosynthesis%3B Ribosomal frameshifting%3B Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA%3B Belongs to the prokaryotic/mitochondrial release factor family gene gene1203 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01204 S101447_01205 S101447_01205 mrcA mrcA 1217761 1220514 - Penicillin-binding protein 1A Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Glycosyltransferase%3B Hydrolase%3B Membrane%3B Multifunctional enzyme%3B Peptidoglycan synthesis%3B Signal-anchor%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity)%3B In the N-terminal sectio%3B belongs to the glycosyltransferase 51 family%3B In the C-terminal sectio%3B belongs to the transpeptidase family%3B KEGG: apt:APA01_00650 penicillin-binding protein 1A%3B Hexosyltransferases gene gene1204 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01205 S101447_01206 S101447_01206 S101447_01206 1220611 1221684 - Heat-inducible transcription repressor HrcA Repressor%3B Stress response%3B Transcription%3B Transcription regulation%3B Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons%3B Belongs to the HrcA family gene gene1205 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01206 S101447_01207 S101447_01207 S101447_01207 1221812 1222546 + tRNA nucleotidyltransferase Nucleotidyltransferase%3B Transferase%3B tRNA processing%3B Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates%3B Belongs to the RNase PH family%3B KEGG: mmt:Metme_4371 ribonuclease PH gene gene1206 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01207 S101447_01208 S101447_01208 rdgB rdgB 1222543 1223142 + XTP/dITP diphosphatase Hydrolase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nucleotide metabolism%3B Nucleotide-binding%3B Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool%2C thus preventing their incorporation into DNA and avoiding chromosomal lesions%3B Belongs to the HAM1 NTPase family%3B KEGG: apt:APA01_00620 XTP/dITP diphosphohydrolase gene gene1207 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01208 S101447_01209 S101447_01209 S101447_01209 1223151 1224401 - hypothetical protein gene gene1208 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01209 S101447_01210 S101447_01210 S101447_01210 1224605 1226323 - 30S ribosomal protein S1 Repeat%3B Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B Binds mRN%3B thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)%3B Belongs to the ribosomal protein S1P family%3B Contains 6 S1 motif domains gene gene1209 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01210 S101447_01211 S101447_01211 S101447_01211 1226608 1227261 - UMP/CMP kinase ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Belongs to the cytidylate kinase family. Type 1 subfamily%3B KEGG: apt:APA01_00590 cytidylate kinase gene gene1210 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01211 S101447_01212 S101447_01212 aroA aroA 1227258 1228607 - 3-phosphoshikimate 1-carboxyvinyltransferase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Cytoplasm%3B Transferase%3B Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate%3B Belongs to the EPSP synthase family%3B KEGG: apt:APA01_00580 3-phosphoshikimate 1-carboxyvinyltransferase gene gene1211 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01212 S101447_01213 S101447_01213 S101447_01213 1228851 1229186 + hypothetical protein gene gene1212 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01213 S101447_01214 S101447_01214 folB folB 1229260 1229661 - Dihydroneopterin aldolase KEGG: apt:APA01_00560 dihydroneopterin aldolase gene gene1213 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01214 S101447_01215 S101447_01215 S101447_01215 1229665 1230465 - 3-oxoacyl-[acyl-carrier-protein] reductase Oxidoreductase%3B Stress response%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: eae:EAE_19740 3-oxoacyl-(acyl-carrier protein) reductase gene gene1214 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01215 S101447_01216 S101447_01216 S101447_01216 1230486 1231082 - Recombination protein RecR DNA damage%3B DNA recombination%3B DNA repair%3B Metal-binding%3B Zinc%3B Zinc-finger%3B May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO%3B Belongs to the RecR family%3B Contains 1 Toprim domain gene gene1215 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01216 S101447_01217 S101447_01217 S101447_01217 1231114 1231437 - Nucleoid-associated protein Cytoplasm%3B DNA-binding%3B Binds to DNA and alters its conformation. May be involved in regulation of gene expression%2C nucleoid organization and DNA protection%3B Belongs to the YbaB/EbfC family gene gene1216 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01217 S101447_01218 S101447_01218 dnaX dnaX 1231537 1233531 - DNA-directed DNA polymerase ATP-binding%3B DNA replication%3B DNA-directed DNA polymerase%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase%3B DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. Belongs to the DnaX/STICHEL family%3B KEGG: apt:APA01_00520 DNA polymerase III subunit gamma/tau gene gene1217 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01218 S101447_01219 S101447_01219 S101447_01219 1233730 1234272 + hypothetical protein gene gene1218 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01219 S101447_01220 S101447_01220 S101447_01220 1234306 1235571 + Beta-N-acetylhexosaminidase Cell inner membrane%3B Cell membrane%3B Membrane%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Intake of glucose and galactose%3B Belongs to the major facilitator superfamily. FHS transporter (TC 2. A. 1. 7) family%3B KEGG: gdj:Gdia_1396 hexosaminidase gene gene1219 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01220 S101447_01221 S101447_01221 nagA nagA 1235584 1236687 + N-acetylglucosamine-6-phosphate deacetylase Carbohydrate metabolism%3B Hydrolase%3B Belongs to the NagA family%3B KEGG: apt:APA01_00490 N-acetylglucosamine-6-phosphate deacetylase gene gene1220 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01221 S101447_01222 S101447_01222 mdoH mdoH 1236737 1238869 - Glucans biosynthesis glucosyltransferase Cell inner membrane%3B Cell membrane%3B Glycosyltransferase%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)%3B Belongs to the glycosyltransferase 2 family. OpgH subfamily%3B KEGG: apt:APA01_00480 membrane glycosyltransferase%3B Hexosyltransferases gene gene1221 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01222 S101447_01223 S101447_01223 S101447_01223 1238872 1240416 - Glucans biosynthesis protein Periplasm%3B Signal%3B Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)%3B Belongs to the OpgD/OpgG family gene gene1222 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01223 S101447_01224 S101447_01224 S101447_01224 1240483 1240848 - Molybdenum transport protein ModE Molybdenum%3B Repeat%3B Transport%3B Involved in the transport of molybdenum into the cell. May have a role in the early intracellular capture or metabolism of molybdenum. Belongs to the ModE family gene gene1223 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01224 S101447_01225 S101447_01225 S101447_01225 1240918 1241430 + hypothetical protein gene gene1224 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01225 S101447_01226 S101447_01226 S101447_01226 1241437 1242471 - Protein RecA ATP-binding%3B Cytoplasm%3B DNA damage%3B DNA recombination%3B DNA repair%3B DNA-binding%3B Nucleotide-binding%3B SOS response%3B It interacts with LexA causing its activation and leading to its autocatalytic cleavage%3B Belongs to the RecA family gene gene1225 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01226 S101447_01227 S101447_01227 S101447_01227 1242724 1244178 - Gamma-glutamyltransferase Acyltransferase%3B Glutathione biosynthesis%3B Hydrolase%3B Protease%3B Secreted%3B Signal%3B Transferase%3B Zymogen%3B Belongs to the gamma-glutamyltransferase family%3B KEGG: apt:APA01_00430 gamma-glutamyltranspeptidase / glutathione hydrolase gene gene1226 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01227 S101447_01228 S101447_01228 dsbC dsbC 1244226 1245104 + Protein disulfide-isomerase KEGG: geb:GM18_1370 thiol:disulfide interchange protein DsbC gene gene1227 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01228 S101447_01229 S101447_01229 alaS alaS 1245157 1246422 - 5-aminolevulinate synthase Acyltransferase%3B Heme biosynthesis%3B Mitochondrion%3B Pyridoxal phosphate%3B Transferase%3B Transit peptide%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: apt:APA01_00410 5-aminolevulinate synthase gene gene1228 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01229 S101447_01230 S101447_01230 S101447_01230 1246525 1247001 - hypothetical protein gene gene1229 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01230 S101447_01231 S101447_01231 tktA tktA 1247159 1249090 + Transketolase Calcium%3B Calvin cycle%3B Magnesium%3B Metal-binding%3B Thiamine pyrophosphate%3B Transferase%3B Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor%2C via a covalent intermediate with the cofactor thiamine pyrophosphate%3B Belongs to the transketolase family%3B KEGG: apt:APA01_00390 transketolase gene gene1230 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01231 S101447_01232 S101447_01232 gapA gapA 1249143 1250165 + Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Calvin cycle%3B Chloroplast%3B NADP%3B Oxidoreductase%3B Plastid%3B Transit peptide%3B Belongs to the glyceraldehyde-3-phosphate dehydrogenase family%3B KEGG: xfa:XF0457 glyceraldehyde 3-phosphate dehydrogenase gene gene1231 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01232 S101447_01233 S101447_01233 S101447_01233 1250165 1251388 + Phosphoglycerate kinase ATP-binding%3B Cytoplasm%3B Glycolysis%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Belongs to the phosphoglycerate kinase family%3B KEGG: apt:APA01_00370 phosphoglycerate kinase gene gene1232 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01233 S101447_01234 S101447_01234 S101447_01234 1251478 1252371 - putative transporter YdfC Cell membrane%3B Membrane%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the EamA transporter family%3B Contains 2 EamA domains gene gene1233 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01234 S101447_01235 S101447_01235 S101447_01235 1252433 1253095 - hypothetical protein gene gene1234 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01235 S101447_01236 S101447_01236 sdhB sdhB 1253273 1254055 - Succinate dehydrogenase (quinone) 2Fe-2S%3B 3Fe-4S%3B 4Fe-4S%3B Electron transport%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase%3B Transport%3B Tricarboxylic acid cycle%3B Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 4Fe-4S ferredoxin-type domain%3B KEGG: bhe:BH15770 succinate dehydrogenase / fumarate reductase%2C iron-sulfur subunit gene gene1235 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01236 S101447_01237 S101447_01237 sdhA sdhA 1254092 1255903 - Succinate dehydrogenase (quinone) Electron transport%3B FAD%3B Flavoprotein%3B Membrane%3B Mitochondrion%3B Mitochondrion inner membrane%3B Oxidoreductase%3B Transit peptide%3B Transport%3B Tricarboxylic acid cycle%3B Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)%3B Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily%3B KEGG: apt:APA01_00330 succinate dehydrogenase / fumarate reductase%2C flavoprotein subunit gene gene1236 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01237 S101447_01238 S101447_01238 S101447_01238 1256021 1256434 - hypothetical protein gene gene1237 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01238 S101447_01239 S101447_01239 S101447_01239 1256436 1256909 - Succinate dehydrogenase cytochrome b556 subunit Cell inner membrane%3B Cell membrane%3B Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Tricarboxylic acid cycle%3B Membrane-anchoring subunit of succinate dehydrogenase (SDH)%3B Belongs to the cytochrome b560 family gene gene1238 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01239 S101447_01240 S101447_01240 S101447_01240 1257046 1258068 - Aspartate-semialdehyde dehydrogenase Amino-acid biosynthesis%3B Diaminopimelate biosynthesis%3B Lysine biosynthesis%3B Methionine biosynthesis%3B NADP%3B Oxidoreductase%3B Threonine biosynthesis%3B Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate%3B Belongs to the aspartate-semialdehyde dehydrogenase family%3B KEGG: ecn:Ecaj_0944 aspartate-semialdehyde dehydrogenase gene gene1239 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01240 S101447_01241 S101447_01241 pntA pntA 1258417 1259625 + NAD(P)(+) transhydrogenase (Re/Si-specific) NAD%3B NADP%3B Nucleotide-binding%3B Oxidoreductase%3B The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane%3B Belongs to the AlaDH/PNT family%3B KEGG: apk:APA386B_1510 NAD(P) transhydrogenase subunit alpha%3B overlaps another CDS with the same product name gene gene1240 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01241 S101447_01242 S101447_01242 S101447_01242 1259622 1259948 + NAD(P)(+) transhydrogenase (Re/Si-specific) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B NADP%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane%3B KEGG: apt:APA01_00270 NAD(P) transhydrogenase subunit alpha%3B overlaps another CDS with the same product name gene gene1241 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01242 S101447_01243 S101447_01243 pntB pntB 1259949 1261364 + NAD(P)(+) transhydrogenase (Re/Si-specific) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B NADP%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane%3B Belongs to the PNT beta subunit family%3B KEGG: apt:APA01_00260 NAD(P) transhydrogenase subunit beta gene gene1242 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01243 S101447_01244 S101447_01244 S101447_01244 1261440 1262468 + Alcohol dehydrogenase Metal-binding%3B NAD%3B Oxidoreductase%3B Zinc%3B Catalytically different from common alcohol dehydrogenases. Effective in oxidizing ethanol%2C other primary alcohols and benzylalcohol only in the presence of p-nitroso-N%2CN- dimethylaniline (NDMA) as an electron acceptor. NADH acts as a cofactor here instead as a coenzyme%3B Belongs to the zinc-containing alcohol dehydrogenase family%3B KEGG: gdj:Gdia_0720 alcohol dehydrogenase%2C propanol-preferring gene gene1243 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01244 S101447_01245 S101447_01245 S101447_01245 1262508 1263899 + Succinate-semialdehyde dehydrogenase (NAD(P)(+)) NADP%3B Oxidoreductase%3B Catalyzes the NADP(+) dependent oxidation of succinate semialdehyde to succinate%3B Belongs to the aldehyde dehydrogenase family%3B KEGG: ecle:ECNIH2_24840 succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase gene gene1244 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01245 S101447_01246 S101447_01246 serC serC 1263982 1265157 - Phosphoserine transaminase Amino-acid biosynthesis%3B Aminotransferase%3B Cytoplasm%3B Pyridoxal phosphate%3B Pyridoxine biosynthesis%3B Serine biosynthesis%3B Transferase%3B Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily%3B KEGG: apt:APA01_00230 phosphoserine aminotransferase gene gene1245 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01246 S101447_01247 S101447_01247 S101447_01247 1265190 1265276 - tRNA-Leu tRNA gene1246 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01247 S101447_01248 S101447_01248 S101447_01248 1265329 1265673 - hypothetical protein gene gene1247 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01248 S101447_01249 S101447_01249 xseA xseA 1265771 1267225 - Exodeoxyribonuclease VII Cytoplasm%3B Exonuclease%3B Hydrolase%3B Nuclease%3B Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides%2C which are then degraded further into small acid-soluble oligonucleotides%3B Belongs to the XseA family%3B KEGG: apt:APA01_00200 exodeoxyribonuclease VII large subunit gene gene1248 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01249 S101447_01250 S101447_01250 purD purD 1267292 1268560 + Phosphoribosylamine--glycine ligase ATP-binding%3B Ligase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nucleotide-binding%3B Purine biosynthesis%3B Belongs to the GARS family%3B Contains 1 ATP-grasp domain%3B KEGG: plu:plu0494 phosphoribosylamine--glycine ligase gene gene1249 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01250 S101447_01251 S101447_01251 rimI rimI 1268612 1269070 - Ribosomal-protein-alanine N-acetyltransferase Acyltransferase%3B Cytoplasm%3B Nucleus%3B Transferase%3B Catalytic component of the NatC N-terminal acetyltransferase%3B Belongs to the acetyltransferase family. MAK3 subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: gox:GOX0774 ribosomal-protein-alanine N-acetyltransferase gene gene1250 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01251 S101447_01252 S101447_01252 S101447_01252 1269067 1269759 - hypothetical protein gene gene1251 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01252 S101447_01253 S101447_01253 rutE rutE 1269756 1270340 - Putative NADH dehydrogenase/NAD(P)H nitroreductase Flavoprotein%3B FMN%3B NAD%3B NADP%3B Oxidoreductase%3B Belongs to the nitroreductase family. HadB/RutE subfamily%3B KEGG: pnu:Pnuc_0932 3-hydroxypropanoate dehydrogenase%3B With NAD(+) or NADP(+) as acceptor gene gene1252 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01253 S101447_01254 S101447_01254 S101447_01254 1270451 1271011 - NifU-like protein Belongs to the NifU family gene gene1253 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01254 S101447_01255 S101447_01255 S101447_01255 1271239 1272471 - uncharacterized protein Cytoplasm%3B Nucleus. gene gene1254 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01255 S101447_01256 S101447_01256 S101447_01256 1272553 1273821 - hypothetical protein gene gene1255 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01256 S101447_01257 S101447_01257 S101447_01257 1273959 1274798 - Creatininase KEGG: apt:APA01_00120 creatinine amidohydrolase gene gene1256 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01257 S101447_01258 S101447_01258 S101447_01258 1274798 1277662 - UvrABC system protein ATP-binding%3B Cytoplasm%3B DNA damage%3B DNA excision%3B DNA repair%3B DNA-binding%3B Excision nuclease%3B Metal-binding%3B Nucleotide-binding%3B Repeat%3B SOS response%3B Zinc%3B Zinc-finger%3B The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB%2C the UvrA molecules dissociate%3B Belongs to the ABC transporter superfamily. UvrA family%3B Contains 2 ABC transporter domains gene gene1257 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01258 S101447_01259 S101447_01259 S101447_01259 1277901 1278860 + uncharacterized protein Contains 1 thioredoxin domain gene gene1258 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01259 S101447_01260 S101447_01260 S101447_01260 1278875 1279579 + Lon protease ATP-binding%3B Cytoplasm%3B Hydrolase%3B Nucleotide-binding%3B Protease%3B Serine protease%3B Stress response%3B ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Binds to DNA in a double-stranded%2C site-specific manner%3B Belongs to the peptidase S16 family%3B Contains 1 Lon domain gene gene1259 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01260 S101447_01261 S101447_01261 S101447_01261 1279606 1279791 + UPF0434 protein Belongs to the UPF0434 family gene gene1260 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01261 S101447_01262 S101447_01262 S101447_01262 1279834 1280208 + hypothetical protein gene gene1261 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01262 S101447_01263 S101447_01263 S101447_01263 1280233 1281480 - Multidrug resistance protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Multidrug resistance pump that participates in a low energy shock adaptive response. Belongs to the major facilitator superfamily gene gene1262 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01263 S101447_01264 S101447_01264 S101447_01264 1281617 1282144 - hypothetical protein gene gene1263 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01264 S101447_01265 S101447_01265 S101447_01265 1282383 1282862 + UPF0178 protein Belongs to the UPF0178 family gene gene1264 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01265 S101447_01266 S101447_01266 S101447_01266 1282992 1283067 - tRNA-Ala tRNA gene1265 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01266 S101447_01267 S101447_01267 S101447_01267 1283157 1283771 - Maf-like protein Cytoplasm%3B Belongs to the maf family gene gene1266 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01267 S101447_01268 S101447_01268 hemE hemE 1284159 1285238 + Uroporphyrinogen decarboxylase Cytoplasm%3B Decarboxylase%3B Lyase%3B Porphyrin biosynthesis%3B Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III%3B Belongs to the uroporphyrinogen decarboxylase family%3B KEGG: apt:APA01_26790 uroporphyrinogen decarboxylase gene gene1267 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01268 S101447_01269 S101447_01269 S101447_01269 1285238 1285936 + Phosphoglycolate phosphatase Hydrolase%3B Magnesium%3B Manganese%3B Metal-binding%3B Catalyzes strongly the dephosphorylation of 6- phosphogluconate (6P-Glu) and slightly the dephosphorylation of dihydroxyacetone phosphate (DHAP) and phosphoenolpyruvate (PEP). Also hydrolyzes both purines (GMP and IMP) and pyrimidines as secondary substrates%3B Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family%3B KEGG: svo:SVI_2553 phosphoglycolate phosphatase gene gene1268 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01269 S101447_01270 S101447_01270 S101447_01270 1285936 1286391 + UPF0093 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0093 family gene gene1269 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01270 S101447_01271 S101447_01271 nudF nudF 1286426 1287001 - ADP-ribose diphosphatase KEGG: gox:GOX0843 ADP-ribose pyrophosphatase gene gene1270 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01271 S101447_01272 S101447_01272 S101447_01272 1287098 1288315 + UPF0226 protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0226 family gene gene1271 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01272 S101447_01273 S101447_01273 S101447_01273 1288379 1288963 + putative cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG4 Cytokinin biosynthesis%3B Hydrolase%3B Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms (By similarity)%3B Belongs to the LOG family gene gene1272 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01273 S101447_01274 S101447_01274 S101447_01274 1289042 1289118 + tRNA-Pro tRNA gene1273 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01274 S101447_01275 S101447_01275 S101447_01275 1289238 1289681 - hypothetical protein gene gene1274 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01275 S101447_01276 S101447_01276 S101447_01276 1290015 1290410 + hypothetical protein gene gene1275 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01276 S101447_01277 S101447_01277 mgmT mgmT 1290675 1291139 - Methylated-DNA--[protein]-cysteine S-methyltransferase Cytoplasm%3B DNA damage%3B DNA repair%3B Methyltransferase%3B Transferase%3B Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated%3B Belongs to the MGMT family%3B KEGG: gox:GOX1069 methylated-DNA-(protein)-cysteine S-methyltransferase gene gene1276 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01277 S101447_01278 S101447_01278 mnmE mnmE 1291311 1292633 + tRNA modification GTPase MnmE Cytoplasm%3B GTP-binding%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Potassium%3B tRNA processing%3B Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs%2C forming tRNA- cmnm(5)s(2)U34%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. TrmE GTPase family%3B Contains 1 TrmE-type G (guanine nucleotide-binding) domain%3B KEGG: apt:APA01_26680 tRNA modification GTPase%3B Acting on acid anhydrides gene gene1277 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01278 S101447_01279 S101447_01279 S101447_01279 1292655 1294535 + tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG Cytoplasm%3B FAD%3B Flavoprotein%3B NAD%3B tRNA processing%3B NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs%2C forming tRNA-cmnm(5)s(2)U34%3B Belongs to the MnmG family gene gene1278 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01279 S101447_01280 S101447_01280 gidB gidB 1294519 1295115 + 16S rRNA (guanine(527)-N(7))-methyltransferase Cytoplasm%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Specifically methylates the N7 position of guanine in position 527 of 16S rRNA%3B Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family%3B KEGG: apt:APA01_26660 16S rRNA (guanine527-N7)-methyltransferase gene gene1279 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01280 S101447_01281 S101447_01281 S101447_01281 1295108 1295905 + Chromosome partitioning protein ParA ATP-binding%3B Chromosome partition%3B Nucleotide-binding%3B Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Belongs to the ParA family gene gene1280 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01281 S101447_01282 S101447_01282 S101447_01282 1295902 1296825 + putative chromosome-partitioning protein ParB Chromosome partition%3B DNA-binding%3B Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity)%3B Belongs to the ParB family gene gene1281 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01282 S101447_01283 S101447_01283 S101447_01283 1296894 1296969 + tRNA-Lys tRNA gene1282 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01283 S101447_01284 S101447_01284 S101447_01284 1297233 1297928 + Glutathione transferase Cytoplasm%3B Phosphoprotein%3B Transferase%3B May have a role in the detoxification of various heavy metals%3B Belongs to the GST superfamily%3B Contains 1 GST C-terminal domain%3B Contains 1 GST N-terminal domain%3B KEGG: sty:STY4465 glutathione S-transferase gene gene1283 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01284 S101447_01285 S101447_01285 S101447_01285 1298596 1299147 + hypothetical protein gene gene1284 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01285 S101447_01286 S101447_01286 recD recD 1299198 1299614 + Exodeoxyribonuclease V KEGG: rum:CK1_26900 exodeoxyribonuclease V alpha subunit gene gene1285 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01286 S101447_01287 S101447_01287 S101447_01287 1299634 1300818 - uncharacterized protein FAD%3B Flavoprotein%3B Monooxygenase%3B Oxidoreductase%3B Belongs to the UbiH/COQ6 family%3B KEGG: aap:NT05HA_2283 2-octaprenylphenol hydroxylase%3B With NADH or NADPH as one donor%2C and incorporation of one atom of oxygen gene gene1286 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01287 S101447_01288 S101447_01288 S101447_01288 1300815 1301411 - Putative NAD(P)H nitroreductase Flavoprotein%3B FMN%3B NAD%3B NADP%3B Oxidoreductase%3B Belongs to the nitroreductase family gene gene1287 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01288 S101447_01289 S101447_01289 S101447_01289 1301445 1301819 - putative 13.2 kDa HIT-like protein in hisE 3'region Contains 1 HIT domain gene gene1288 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01289 S101447_01290 S101447_01290 hisE hisE 1301826 1302260 - Phosphoribosyl-ATP diphosphatase Amino-acid biosynthesis%3B ATP-binding%3B Cytoplasm%3B Histidine biosynthesis%3B Hydrolase%3B Multifunctional enzyme%3B Nucleotide-binding%3B In the N-terminal sectio%3B belongs to the PRA-CH family%3B In the C-terminal sectio%3B belongs to the PRA-PH family%3B KEGG: apt:APA01_26560 phosphoribosyl-ATP pyrophosphohydrolase gene gene1289 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01290 S101447_01291 S101447_01291 hisF hisF 1302269 1303045 - Putative imidazole glycerol phosphate synthase subunit hisF2 Amino-acid biosynthesis%3B Cytoplasm%3B Histidine biosynthesis%3B Lyase%3B IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)%3B Belongs to the HisA/HisF family%3B KEGG: vvy:VV0319 cyclase%3B Oxo-acid-lyases gene gene1290 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01291 S101447_01292 S101447_01292 hisA hisA 1303045 1304370 - 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamideisomerase Acyltransferase%3B Transferase%3B Contains 1 N-acetyltransferase domain%3B KEGG: apt:APA01_26540 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase gene gene1291 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01292 S101447_01293 S101447_01293 hisH hisH 1304370 1305026 - Imidazole glycerol phosphate synthase subunit HisH Amino-acid biosynthesis%3B Cytoplasm%3B Glutamine amidotransferase%3B Histidine biosynthesis%3B Transferase%3B IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: apt:APA01_26530 glutamine amidotransferase%3B Pentosyltransferases gene gene1292 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01293 S101447_01294 S101447_01294 hisB hisB 1305173 1305769 - Imidazoleglycerol-phosphate dehydratase Amino-acid biosynthesis%3B Cytoplasm%3B Histidine biosynthesis%3B Lyase%3B Belongs to the imidazoleglycerol-phosphate dehydratase family%3B KEGG: apt:APA01_26520 imidazoleglycerol-phosphate dehydratase gene gene1293 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01294 S101447_01295 S101447_01295 qns1 qns1 1305845 1307890 - NAD(+) synthase (glutamine-hydrolyzing) ATP-binding%3B Ligase%3B NAD%3B Nucleotide-binding%3B Can use both glutamine or ammonia as a nitrogen source%3B In the C-terminal sectio%3B belongs to the NAD synthetase family%3B Contains 1 CN hydrolase domain%3B KEGG: apk:APA386B_1457 NAD+ synthase (glutamine-hydrolysing) gene gene1294 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01295 S101447_01296 S101447_01296 S101447_01296 1308075 1308149 + tRNA-Gly tRNA gene1295 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01296 S101447_01297 S101447_01297 S101447_01297 1308292 1311489 - hypothetical protein gene gene1296 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01297 S101447_01298 S101447_01298 S101447_01298 1311808 1313229 + hypothetical protein gene gene1297 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01298 S101447_01299 S101447_01299 S101447_01299 1313360 1316179 + hypothetical protein gene gene1298 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01299 S101447_01300 S101447_01300 S101447_01300 1316176 1317135 - hypothetical protein gene gene1299 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01300 S101447_01301 S101447_01301 S101447_01301 1317247 1317516 + DNA-binding protein HU like protein Cell wall%3B DNA condensation%3B DNA-binding%3B Repeat%3B Secreted%3B Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it%2C and thus to prevent its denaturation under extreme environmental conditions%3B Belongs to the bacterial histone-like protein family gene gene1300 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01301 S101447_01302 S101447_01302 S101447_01302 1317590 1318831 - Macrolide efflux protein A Antibiotic resistance%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides but not to 16-membered macrolides%2C lincosamides or analogs of streptogramin B. May function as an efflux pump to regulate intracellular macrolide levels (By similarity)%3B Belongs to the major facilitator superfamily. MefA (TC 2. A. 1. 21. 1) family gene gene1301 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01302 S101447_01303 S101447_01303 S101447_01303 1319117 1319191 - tRNA-Gln tRNA gene1302 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01303 S101447_01304 S101447_01304 S101447_01304 1319281 1319922 - hypothetical protein gene gene1303 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01304 S101447_01305 S101447_01305 proC proC 1319980 1320801 - Pyrroline-5-carboxylate reductase Amino-acid biosynthesis%3B Cytoplasm%3B NADP%3B Oxidoreductase%3B Proline biosynthesis%3B Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline%3B Belongs to the pyrroline-5-carboxylate reductase family%3B KEGG: apt:APA01_26410 pyrroline-5-carboxylate reductase gene gene1304 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01305 S101447_01306 S101447_01306 S101447_01306 1320801 1321301 - hypothetical protein gene gene1305 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01306 S101447_01307 S101447_01307 S101447_01307 1321357 1321659 - hypothetical protein gene gene1306 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01307 S101447_01308 S101447_01308 S101447_01308 1321940 1322110 + hypothetical protein gene gene1307 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01308 S101447_01309 S101447_01309 S101447_01309 1322107 1323024 + Chaperone protein DnaJ Chaperone%3B Cytoplasm%3B DNA replication%3B Metal-binding%3B Repeat%3B Stress response%3B Zinc%3B Zinc-finger%3B Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins%2C also in an autonomous%2C DnaK-independent fashion. Unfolded proteins bind initially to Dna%3B upon interaction with the DnaJ-bound protein%2C DnaK hydrolyzes its bound ATP%2C resulting in the formation of a stable complex. GrpE releases ADP from Dna%3B ATP binding to DnaK triggers the release of the substrate protein%2C thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ%2C DnaK and GrpE are required for fully efficient folding. Also involved%2C together with DnaK and GrpE%2C in the DNA replication of plasmids through activation of initiation proteins%3B Belongs to the DnaJ family%3B Contains 1 CR-type zinc finger%3B Contains 1 J domain gene gene1308 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01309 S101447_01310 S101447_01310 S101447_01310 1323088 1323504 - hypothetical protein gene gene1309 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01310 S101447_01311 S101447_01311 S101447_01311 1323671 1323835 + hypothetical protein gene gene1310 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01311 S101447_01312 S101447_01312 S101447_01312 1323865 1324617 - hypothetical protein gene gene1311 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01312 S101447_01313 S101447_01313 S101447_01313 1324610 1327141 - Large-conductance mechanosensitive channel MscMJLR Cell membrane%3B Ion channel%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Large-conductance mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Selective for cations. Rectifies with voltage%3B Belongs to the MscS (TC 1. A. 23) family gene gene1312 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01313 S101447_01314 S101447_01314 S101447_01314 1327288 1327917 - hypothetical protein gene gene1313 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01314 S101447_01315 S101447_01315 argJ argJ 1327978 1329225 - Glutamate N-acetyltransferase Acyltransferase%3B Amino-acid biosynthesis%3B Arginine biosynthesis%3B Autocatalytic cleavage%3B Cytoplasm%3B Multifunctional enzyme%3B Transferase%3B Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor%2C and of ornithine by transacetylation between N(2)-acetylornithine and glutamate%3B Belongs to the ArgJ family%3B KEGG: apt:APA01_26310 glutamate N-acetyltransferase / amino-acid N-acetyltransferase gene gene1314 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01315 S101447_01316 S101447_01316 ppiC ppiC 1329301 1330245 - Peptidylprolyl isomerase Cell outer membrane%3B Isomerase%3B Membrane%3B Rotamase%3B Signal%3B Belongs to the PpiC/parvulin rotamase family%3B Contains 1 PpiC domain%3B KEGG: apt:APA01_26300 peptidyl-prolyl cis-trans isomerase C gene gene1315 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01316 S101447_01317 S101447_01317 S101447_01317 1330448 1333174 + Protein translocase subunit SecA ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Cytoplasm%3B Membrane%3B Metal-binding%3B Nucleotide-binding%3B Protein transport%3B Translocation%3B Transport%3B Zinc%3B Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane%2C serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane%3B Belongs to the SecA family gene gene1316 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01317 S101447_01318 S101447_01318 S101447_01318 1333214 1333963 + putative transcriptional regulatory protein Cytoplasm%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Belongs to the TACO1 family gene gene1317 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01318 S101447_01319 S101447_01319 ruvC ruvC 1333970 1334476 + Crossover junction endodeoxyribonuclease DNA damage%3B DNA recombination%3B DNA repair%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nuclease%3B Nuclease that resolves Holliday junction intermediates in genetic recombination%3B Belongs to the RuvC family%3B KEGG: apac:S7S_06300 crossover junction endodeoxyribonuclease RuvC gene gene1318 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01319 S101447_01320 S101447_01320 ruvA ruvA 1334473 1335081 + DNA helicase ATP-binding%3B DNA damage%3B DNA recombination%3B DNA repair%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B SOS response%3B RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates%2C in the presence of DNA%2C the weak ATPase activity of RuvB%3B Belongs to the RuvA family%3B KEGG: apt:APA01_26260 holliday junction DNA helicase RuvA%3B overlaps another CDS with the same product name gene gene1319 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01320 S101447_01321 S101447_01321 ruvB ruvB 1335078 1336154 + DNA helicase ATP-binding%3B DNA damage%3B DNA recombination%3B DNA repair%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B SOS response%3B RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing%3B Belongs to the RuvB family%3B KEGG: apt:APA01_26250 holliday junction DNA helicase RuvB%3B overlaps another CDS with the same product name gene gene1320 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01321 S101447_01322 S101447_01322 ybgC ybgC 1336151 1336564 + Acyl-CoA thioester hydrolase Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Lipid metabolism%3B Membrane%3B Thioesterase that appears to be involved in phospholipid metabolism. Some specific acyl-ACPs could be physiological substrates. Displays acyl-CoA thioesterase activity on malonyl-CoA in vitro%2C catalyzing the hydrolysis of the thioester bond (By similarity)%3B Belongs to the 4-hydroxybenzoyl-CoA thioesterase family%3B KEGG: apt:APA01_26240 acyl-CoA thioester hydrolase%3B Thiolester hydrolases gene gene1321 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01322 S101447_01323 S101447_01323 S101447_01323 1336684 1337403 + Biopolymer transport protein Bacteriocin transport%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity)%3B Belongs to the ExbB/TolQ family gene gene1322 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01323 S101447_01324 S101447_01324 S101447_01324 1337407 1337838 + Protein TolR Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-independent uptake of proteins%3B Belongs to the ExbD/TolR family gene gene1323 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01324 S101447_01325 S101447_01325 S101447_01325 1337870 1338877 + RE1-silencing transcription factor Alternative splicing%3B Metal-binding%3B Nucleus%3B Phosphoprotein%3B Repeat%3B Repressor%3B Transcription%3B Transcription regulation%3B Zinc%3B Zinc-finger%3B Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors%2C mSin3 and CoREST%2C which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones%2C thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (By similarity)%3B Contains 9 C2H2-type zinc fingers gene gene1324 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01325 S101447_01326 S101447_01326 S101447_01326 1338901 1340265 + Protein TolB Periplasm%3B Protein transport%3B Signal%3B Transport%3B Involved in the TonB-independent uptake of proteins%3B Belongs to the TolB family gene gene1325 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01326 S101447_01327 S101447_01327 S101447_01327 1340589 1341071 + Outer membrane lipoprotein Omp16 like protein Cell outer membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Belongs to the OmpA family. Pal subfamily%3B Contains 1 OmpA-like domain gene gene1326 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01327 S101447_01328 S101447_01328 S101447_01328 1341213 1341953 + hypothetical protein gene gene1327 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01328 S101447_01329 S101447_01329 tilS tilS 1341962 1343269 + tRNA(Ile)-lysidine synthetase ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B tRNA processing%3B Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU%2C in an ATP-dependent manner. Cytidine is converted to lysidine%2C thus changing the amino acid specificity of the tRNA from methionine to isoleucine%3B Belongs to the tRNA(Ile)-lysidine synthase family%3B KEGG: apt:APA01_26170 tRNA(Ile)-lysidine synthase gene gene1328 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01329 S101447_01330 S101447_01330 ftsH ftsH 1343407 1345344 + ATP-dependent zinc metalloprotease FtsH ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Metal-binding%3B Metalloprotease%3B Nucleotide-binding%3B Protease%3B Transmembrane%3B Transmembrane helix%3B Zinc%3B Acts as a processive%2C ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins%3B In the central sectio%3B belongs to the AAA ATPase family%3B In the C-terminal sectio%3B belongs to the peptidase M41 family%3B KEGG: caq:IM40_06400 cell division protease FtsH%3B Metalloendopeptidases gene gene1329 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01330 S101447_01331 S101447_01331 folP folP 1345385 1346455 + Dihydropteroate synthase Folate biosynthesis%3B Magnesium%3B Metal-binding%3B Transferase%3B Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7%2C8-dihydropterin diphosphate (DHPt-PP) to form 7%2C8-dihydropteroate (H2Pte)%2C the immediate precursor of folate derivatives%3B Belongs to the DHPS family%3B Contains 1 pterin-binding domain%3B KEGG: apt:APA01_26150 dihydropteroate synthase gene gene1330 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01331 S101447_01332 S101447_01332 glmM glmM 1346589 1347947 + Phosphoglucosamine mutase Isomerase%3B Magnesium%3B Metal-binding%3B Phosphoprotein%3B Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate%3B Belongs to the phosphohexose mutase family%3B KEGG: apt:APA01_26140 phosphoglucosamine mutase gene gene1331 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01332 S101447_01333 S101447_01333 S101447_01333 1348115 1348897 - Transcriptional regulatory protein Activator%3B Antibiotic resistance%3B Cytoplasm%3B DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system%3B Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd%2C ais%2C arnBCADTEF and eptA-basRS loci%2C all involved in resistance to polymyxin (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1332 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01333 S101447_01334 S101447_01334 S101447_01334 1349260 1349745 + tRNA threonylcarbamoyladenosine biosynthesis protein TsaE ATP-binding%3B Cytoplasm%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B tRNA processing%3B Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37%2C together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway%2C possibly in regulating the core enzymatic function of TsaD (By similarity)%3B Belongs to the TsaE family gene gene1333 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01334 S101447_01335 S101447_01335 S101447_01335 1349742 1352831 + uncharacterized protein KEGG: gdj:Gdia_1296 ATP-dependent helicase/nuclease subunit B%3B Acting on ester bonds gene gene1334 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01335 S101447_01336 S101447_01336 addA addA 1352828 1356403 + ATP-dependent helicase/nuclease subunit ATP-binding%3B DNA damage%3B DNA repair%3B DNA-binding%3B Exonuclease%3B Helicase%3B Hydrolase%3B Nuclease%3B Nucleotide-binding%3B The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent%2C dual-direction single-stranded exonuclease%3B this subunit has the helicase and 3' -> 5' nuclease activities%3B Belongs to the helicase family. AddA subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B Contains 1 uvrD-like helicase C-terminal domain%3B KEGG: apt:APA01_26100 ATP-dependent helicase/nuclease subunit A%3B Acting on ester bonds gene gene1335 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01336 S101447_01337 S101447_01337 S101447_01337 1356531 1356857 + Thioredoxin Disulfide bond%3B Electron transport%3B Redox-active center%3B Transport%3B Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Belongs to the thioredoxin family%3B Contains 1 thioredoxin domain gene gene1336 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01337 S101447_01338 S101447_01338 accD accD 1357041 1357946 + Acetyl-CoA carboxylase ATP-binding%3B Cytoplasm%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Ligase%3B Lipid biosynthesis%3B Lipid metabolism%3B Metal-binding%3B Nucleotide-binding%3B Zinc%3B Zinc-finger%3B Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA%3B Belongs to the AccD/PCCB family%3B KEGG: caq:IM40_04300 acetyl-CoA carboxylase carboxyl transferase subunit beta gene gene1337 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01338 S101447_01339 S101447_01339 folC folC 1357954 1359291 + Dihydrofolate synthase ATP-binding%3B Folate biosynthesis%3B Ligase%3B Magnesium%3B Metal-binding%3B Multifunctional enzyme%3B Nucleotide-binding%3B Transferase%3B Can complement an H. volcanii mutant strain that is thymidine auxotroph because it lacks the two dihydrofolate reductase genes encoded by hdrA and hdrB%3B In the N-terminal sectio%3B belongs to the folylpolyglutamate synthase family%3B In the C-terminal sectio%3B belongs to the DHPS family%3B Contains 1 pterin-binding domain%3B KEGG: apk:APA386B_1413 dihydrofolate synthase / folylpolyglutamate synthase gene gene1338 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01339 S101447_01340 S101447_01340 S101447_01340 1359337 1359411 - tRNA-Thr tRNA gene1339 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01340 S101447_01341 S101447_01341 carS carS 1359484 1360917 + Cysteine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B Zinc%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: apt:APA01_26050 cysteinyl-tRNA synthetase gene gene1340 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01341 S101447_01342 S101447_01342 lasT lasT 1360914 1361684 + tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ Cytoplasm%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B tRNA processing%3B Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA%3B Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family%3B KEGG: gbe:GbCGDNIH1_1137 tRNA/rRNA methyltransferase%3B Methyltransferases gene gene1341 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01342 S101447_01343 S101447_01343 S101447_01343 1361753 1362418 - uncharacterized protein gene gene1342 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01343 S101447_01344 S101447_01344 iscS iscS 1362893 1364050 + Cysteine desulfurase Iron%3B Iron-sulfur%3B Metal-binding%3B Pyridoxal phosphate%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily%3B KEGG: apt:APA01_26020 cysteine desulfurase gene gene1343 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01344 S101447_01345 S101447_01345 S101447_01345 1364058 1365221 + Cysteine desulfurase 2Fe-2S%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Pyridoxal phosphate%3B Transferase%3B Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly%2C tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU%2C an Fe-S scaffold assembly protein%2C as well as other S acceptor proteins%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily%3B KEGG: apt:APA01_26010 cysteine desulfurase gene gene1344 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01345 S101447_01346 S101447_01346 S101447_01346 1365299 1365613 + Adrenodoxin-like protein%2C mitochondrial 2Fe-2S%3B Electron transport%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Mitochondrion%3B Transit peptide%3B Transport%3B Belongs to the adrenodoxin/putidaredoxin family%3B Contains 1 2Fe-2S ferredoxin-type domain gene gene1345 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01346 S101447_01347 S101447_01347 mnmA mnmA 1365641 1366723 + tRNA-specific 2-thiouridylase MnmA ATP-binding%3B Cytoplasm%3B Disulfide bond%3B Nucleotide-binding%3B RNA-binding%3B Transferase%3B tRNA processing%3B tRNA-binding%3B Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA%2C leading to the formation of s(2)U34%3B Belongs to the MnmA/TRMU family%3B KEGG: ade:Adeh_1482 tRNA-specific 2-thiouridylase%3B Sulfurtransferases gene gene1346 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01347 S101447_01348 S101447_01348 S101447_01348 1366748 1367419 + Glutathione transferase KEGG: gdj:Gdia_0613 glutathione S-transferase gene gene1347 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01348 S101447_01349 S101447_01349 S101447_01349 1367476 1368570 + hypothetical protein gene gene1348 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01349 S101447_01350 S101447_01350 rluA rluA 1368592 1369194 - tRNA pseudouridine(32) synthase Isomerase%3B Belongs to the pseudouridine synthase RluA family%3B KEGG: gbe:GbCGDNIH1_0100 tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase gene gene1349 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01350 S101447_01351 S101447_01351 S101447_01351 1369266 1371881 - DNA translocase FtsK ATP-binding%3B Cell cycle%3B Cell division%3B Cell inner membrane%3B Cell membrane%3B Chromosome partition%3B DNA-binding%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site%2C which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites%2C where FtsK interacts with the Xer recombinase%2C allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates%2C but translocation stops specifically at XerCD-dif site%2C thereby preventing removal of XerC and XerD from dif (By similarity)%3B Belongs to the FtsK/SpoIIIE/SftA family%3B Contains 1 FtsK domain gene gene1350 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01351 S101447_01352 S101447_01352 S101447_01352 1372149 1373096 - hypothetical protein gene gene1351 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01352 S101447_01353 S101447_01353 rfbD rfbD 1373205 1374110 - dTDP-4-dehydrorhamnose reductase Lipopolysaccharide biosynthesis%3B NADP%3B Oxidoreductase%3B Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose%3B Belongs to the dTDP-4-dehydrorhamnose reductase family%3B KEGG: apt:APA01_25930 dTDP-4-dehydrorhamnose reductase gene gene1352 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01353 S101447_01354 S101447_01354 rfbC rfbC 1374113 1374685 - dTDP-4-dehydrorhamnose 3%2C5-epimerase Isomerase%3B Lipopolysaccharide biosynthesis%3B Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose%2C forming dTDP-6-deoxy-L-lyxo-4- hexulose%3B Belongs to the dTDP-4-dehydrorhamnose 3%2C5-epimerase family%3B KEGG: apt:APA01_25920 dTDP-4-dehydrorhamnose 3%2C5-epimerase gene gene1353 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01354 S101447_01355 S101447_01355 rfbA rfbA 1374734 1375645 - Glucose-1-phosphate thymidylyltransferase Antibiotic biosynthesis%3B Magnesium%3B Metal-binding%3B Nucleotidyltransferase%3B Transferase%3B Catalyzes the formation of dTDP-glucose%2C from dTTP and glucose 1-phosphate in the novobiocin biosynthesis pathway%2C an aminocoumarin family antibiotic that targets bacterial DNA gyrases. Belongs to the glucose-1-phosphate thymidylyltransferase family%3B KEGG: apt:APA01_25910 glucose-1-phosphate thymidylyltransferase gene gene1354 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01355 S101447_01356 S101447_01356 rfbB rfbB 1375642 1376700 - dTDP-glucose 4%2C6-dehydratase Lyase%3B NAD%3B Lyase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1. 75 M instead of 3. 4 M). Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg%2C consisting of a sulfated hexose%2C 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily%3B KEGG: eco:b2041 dTDP-glucose 4%2C6-dehydratase gene gene1355 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01356 S101447_01357 S101447_01357 S101447_01357 1376902 1379049 + hypothetical protein gene gene1356 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01357 S101447_01358 S101447_01358 cobC cobC 1379068 1379562 + Adenosylcobalamin/alpha-ribazole phosphatase KEGG: rpm:RSPPHO_01551 alpha-ribazole phosphatase%3B overlaps another CDS with the same product name gene gene1357 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01358 S101447_01359 S101447_01359 S101447_01359 1379559 1379798 + Adenosylcobalamin/alpha-ribazole phosphatase KEGG: rce:RC1_2369 alpha-ribazole phosphatase%3B overlaps another CDS with the same product name gene gene1358 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01359 S101447_01360 S101447_01360 S101447_01360 1379924 1381381 + Metalloprotease TldD like protein Hydrolase%3B Metalloprotease%3B Protease%3B Probable metalloprotease%3B Belongs to the peptidase U62 family gene gene1359 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01360 S101447_01361 S101447_01361 yarS yarS 1381531 1382769 + Tyrosine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B RNA-binding%3B Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)%3B Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily%3B Contains 1 S4 RNA-binding domain%3B KEGG: baci:B1NLA3E_17400 tyrosyl-tRNA synthetase gene gene1360 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01361 S101447_01362 S101447_01362 S101447_01362 1382791 1383198 + Heterogeneous nuclear ribonucleoprotein A0 Acetylation%3B Isopeptide bond%3B Methylation%3B Nucleus%3B Phosphoprotein%3B Repeat%3B Ribonucleoprotein%3B RNA-binding%3B Ubl conjugation%3B mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post- transcriptional regulation of cytokines mRNAs%3B Contains 2 RRM (RNA recognition motif) domains gene gene1361 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01362 S101447_01363 S101447_01363 lpcC lpcC 1383324 1384415 + Lipopolysaccharide core biosynthesis mannosyltransferase LpcC Glycosyltransferase%3B Lipopolysaccharide biosynthesis%3B Transferase%3B Acts at transfer of mannose group to a 3-deoxy-D-mono octulonic acid (KDO) via an alpha-1%2C5 linkage. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: mes:Meso_2117 mannosyltransferase%3B Hexosyltransferases gene gene1362 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01363 S101447_01364 S101447_01364 S101447_01364 1384525 1384599 - tRNA-Thr tRNA gene1363 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01364 S101447_01365 S101447_01365 S101447_01365 1384671 1385084 - RNA polymerase-binding transcription factor DksA Cytoplasm%3B Metal-binding%3B Zinc%3B Zinc-finger%3B Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters%3B Belongs to the DksA family%3B Contains 1 dksA C4-type zinc finger gene gene1364 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01365 S101447_01366 S101447_01366 S101447_01366 1385300 1386574 - hypothetical protein gene gene1365 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01366 S101447_01367 S101447_01367 S101447_01367 1386636 1387193 - Single-stranded DNA-binding protein DNA damage%3B DNA recombination%3B DNA repair%3B DNA replication%3B DNA-binding%3B Plays an important role in DNA replication%2C recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism%3B Contains 1 SSB domain gene gene1366 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01367 S101447_01368 S101447_01368 rsmD rsmD 1387271 1387855 - 16S rRNA (guanine(966)-N(2))-methyltransferase Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle%3B Belongs to the methyltransferase superfamily. RsmD family%3B KEGG: apt:APA01_25710 16S rRNA (guanine966-N2)-methyltransferase gene gene1367 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01368 S101447_01369 S101447_01369 rluB rluB 1387855 1388631 - 23S rRNA pseudouridine(2605) synthase Isomerase%3B RNA-binding%3B rRNA processing%3B Responsible for synthesis of pseudouridine from uracil- 2633 in 23S ribosomal RNA. Belongs to the pseudouridine synthase RsuA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: bqu:BQ02470 23S rRNA pseudouridine2605 synthase gene gene1368 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01369 S101447_01370 S101447_01370 S101447_01370 1388628 1389359 - Putative glutamine amidotransferase-like protein Glutamine amidotransferase%3B Transferase%3B Contains 1 glutamine amidotransferase type-1 domain%3B Contains 1 RPE1 insert domain gene gene1369 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01370 S101447_01371 S101447_01371 S101447_01371 1389483 1389635 - hypothetical protein gene gene1370 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01371 S101447_01372 S101447_01372 codA codA 1389857 1390312 + Cytosine deaminase Hydrolase%3B Metal-binding%3B tRNA processing%3B Zinc%3B Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)%3B Belongs to the cytidine and deoxycytidylate deaminase family%3B Contains 1 CMP/dCMP-type deaminase domain%3B KEGG: psu:Psesu_0267 cytosine deaminase gene gene1371 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01372 S101447_01373 S101447_01373 S101447_01373 1390488 1392056 + Peptidase Do Hydrolase%3B Periplasm%3B Protease%3B Repeat%3B Serine protease%3B Signal%3B Stress response%3B Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions%3B Belongs to the peptidase S1C family%3B Contains 2 PDZ (DHR) domains%3B KEGG: apt:APA01_25660 serine protease Do gene gene1372 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01373 S101447_01374 S101447_01374 S101447_01374 1392125 1392943 - Nitrogen fixation regulation protein FixK Activator%3B DNA-binding%3B Nitrogen fixation%3B Transcription%3B Transcription regulation%3B B. FixK may bind DNA at the FNR consensus binding site. Contains 1 cyclic nucleotide-binding domain%3B Contains 1 HTH crp-type DNA-binding domain gene gene1373 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01374 S101447_01375 S101447_01375 S101447_01375 1393222 1394055 + hypothetical protein gene gene1374 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01375 S101447_01376 S101447_01376 hemN hemN 1394064 1395449 + Coproporphyrinogen dehydrogenase 4Fe-4S%3B Bacteriochlorophyll biosynthesis%3B Chlorophyll biosynthesis%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase%3B Porphyrin biosynthesis%3B S-adenosyl-L-methionine%3B Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX. Dedicated to bacteriochlorophyll biosynthesis. Belongs to the anaerobic coproporphyrinogen-III oxidase family%3B KEGG: apt:APA01_25630 oxygen-independent coproporphyrinogen III oxidase gene gene1375 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01376 S101447_01377 S101447_01377 S101447_01377 1395586 1396263 + hypothetical protein gene gene1376 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01377 S101447_01378 S101447_01378 S101447_01378 1396376 1398013 + Electron-transferring-flavoprotein dehydrogenase 4Fe-4S%3B Electron transport%3B FAD%3B Flavoprotein%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B Mitochondrion%3B Mitochondrion inner membrane%3B Oxidoreductase%3B Transit peptide%3B Transport%3B Ubiquinone%3B Accepts electrons from ETF and reduces ubiquinone. May act downstream of IVD and D2HGDH in the degradation of phytol or chlorophyll during dark-induced senescence and sugar starvation%3B Belongs to the ETF-QO/FixC family%3B Contains 1 4Fe-4S ferredoxin-type domain%3B KEGG: apt:APA01_25610 electron-transferring-flavoprotein dehydrogenase gene gene1377 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01378 S101447_01379 S101447_01379 S101447_01379 1398077 1398826 + Electron transfer flavoprotein subunit beta%2C mitochondrial Alternative splicing%3B Electron transport%3B FAD%3B Flavoprotein%3B Mitochondrion%3B Transit peptide%3B Transport%3B The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases%2C including five acyl- CoA dehydrogenases%2C glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Involved in leucine catabolism and in phytol degradation%3B Belongs to the ETF beta-subunit/FixA family gene gene1378 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01379 S101447_01380 S101447_01380 S101447_01380 1398829 1399755 + Electron transfer flavoprotein subunit alpha Electron transport%3B FAD%3B Flavoprotein%3B Transport%3B The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity)%3B Belongs to the ETF alpha-subunit/FixB family gene gene1379 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01380 S101447_01381 S101447_01381 S101447_01381 1399831 1400472 - HTH-type transcriptional repressor AcnR DNA-binding%3B Magnesium%3B Metal-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B AcnR negatively controls the expression of the aconitase gene acn%3B Contains 1 HTH tetR-type DNA-binding domain gene gene1380 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01381 S101447_01382 S101447_01382 S101447_01382 1400610 1402145 + Nodulation protein Cell membrane%3B Lipoprotein%3B Membrane%3B Nodulation%3B Palmitate%3B Plasmid%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene1381 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01382 S101447_01383 S101447_01383 S101447_01383 1402559 1404046 + 16S ribosomal RNA rRNA gene1382 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01383 S101447_01384 S101447_01384 S101447_01384 1404262 1404338 + tRNA-Ile tRNA gene1383 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01384 S101447_01385 S101447_01385 S101447_01385 1404363 1404438 + tRNA-Ala tRNA gene1384 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01385 S101447_01386 S101447_01386 S101447_01386 1404770 1407512 + 23S ribosomal RNA rRNA gene1385 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01386 S101447_01387 S101447_01387 S101447_01387 1407621 1407736 + 5S ribosomal RNA rRNA gene1386 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01387 S101447_01388 S101447_01388 S101447_01388 1407792 1407868 + tRNA-Met tRNA gene1387 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01388 S101447_01389 S101447_01389 holA holA 1408347 1409360 - DNA-directed DNA polymerase KEGG: apt:APA01_25500 DNA polymerase III subunit delta gene gene1388 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01389 S101447_01390 S101447_01390 S101447_01390 1409376 1410071 - hypothetical protein gene gene1389 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01390 S101447_01391 S101447_01391 larS larS 1410071 1412689 - Leucine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: apt:APA01_25480 leucyl-tRNA synthetase gene gene1390 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01391 S101447_01392 S101447_01392 S101447_01392 1412749 1413285 - uncharacterized protein Membrane%3B Transmembrane%3B Transmembrane helix. gene gene1391 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01392 S101447_01393 S101447_01393 S101447_01393 1413525 1414619 - hypothetical protein gene gene1392 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01393 S101447_01394 S101447_01394 S101447_01394 1414691 1414912 - hypothetical protein gene gene1393 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01394 S101447_01395 S101447_01395 S101447_01395 1415098 1415634 - hypothetical protein gene gene1394 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01395 S101447_01396 S101447_01396 mutY mutY 1415765 1416718 + A/G-specific adenine glycosylase 4Fe-4S%3B DNA damage%3B DNA repair%3B Glycosidase%3B Hydrolase%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Adenine glycosylase active on G-A and C-A mispairs%3B Belongs to the Nth/MutY family%3B KEGG: buc:BU552 A/G-specific adenine glycosylase%3B Hydrolyzing N-glycosyl compounds gene gene1395 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01396 S101447_01397 S101447_01397 hemH hemH 1416721 1417749 + Protoporphyrin ferrochelatase Cytoplasm%3B Heme biosynthesis%3B Iron%3B Lyase%3B Metal-binding%3B Porphyrin biosynthesis%3B Catalyzes the ferrous insertion into protoporphyrin IX%3B Belongs to the ferrochelatase family%3B KEGG: apt:APA01_25420 ferrochelatase gene gene1396 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01397 S101447_01398 S101447_01398 S101447_01398 1417788 1418597 - DNA-(apurinic or apyrimidinic site) lyase 4Fe-4S%3B DNA damage%3B DNA repair%3B DNA-binding%3B Glycosidase%3B Hydrolase%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding%3B DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond%2C leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination%2C leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate%3B Belongs to the Nth/MutY family%3B Contains 1 HhH domain%3B KEGG: apt:APA01_25410 endonuclease III gene gene1397 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01398 S101447_01399 S101447_01399 S101447_01399 1418666 1420507 + Iron-sulfur clusters transporter atm1%2C mitochondrial ATP-binding%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Mitochondrion%3B Mitochondrion inner membrane%3B Nucleotide-binding%3B Transit peptide%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound. Also has an indirect role in vacuolar function where it is required for fluid-phase endocytosis%3B Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3. A. 1. 210) subfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene1398 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01399 S101447_01400 S101447_01400 S101447_01400 1420563 1420655 - tRNA-Ser tRNA gene1399 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01400 S101447_01401 S101447_01401 gatB gatB 1420759 1422213 - Asparaginyl-tRNA synthase (glutamine-hydrolyzing) ATP-binding%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)%3B Belongs to the GatB/GatE family. GatB subfamily%3B KEGG: gdj:Gdia_3373 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B%3B overlaps another CDS with the same product name gene gene1400 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01401 S101447_01402 S101447_01402 gatA gatA 1422210 1423697 - Asparaginyl-tRNA synthase (glutamine-hydrolyzing) ATP-binding%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)%3B Belongs to the amidase family. GatA subfamily%3B KEGG: apt:APA01_25370 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A%3B overlaps another CDS with the same product name gene gene1401 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01402 S101447_01403 S101447_01403 gatC gatC 1423697 1423984 - Asparaginyl-tRNA synthase (glutamine-hydrolyzing) ATP-binding%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)%3B Belongs to the GatC family%3B KEGG: apt:APA01_25360 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C%3B overlaps another CDS with the same product name gene gene1402 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01403 S101447_01404 S101447_01404 ruvX ruvX 1424065 1424529 + Putative pre-16S rRNA nuclease Cytoplasm%3B Hydrolase%3B Nuclease%3B Ribosome biogenesis%3B Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA%3B Belongs to the YqgF nuclease family%3B KEGG: apt:APA01_25350 putative holliday junction resolvase%3B Acting on ester bonds gene gene1403 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01404 S101447_01405 S101447_01405 S101447_01405 1424632 1425189 + hypothetical protein gene gene1404 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01405 S101447_01406 S101447_01406 S101447_01406 1425280 1425387 - hypothetical protein gene gene1405 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01406 S101447_01407 S101447_01407 gabT gabT 1425562 1426848 - 4-aminobutyrate--2-oxoglutarate transaminase Aminotransferase%3B Pyridoxal phosphate%3B Transferase%3B Catalyzes the transfer of the amino group from gamma- aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semialdehyde (SSA)%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: eco:b2662 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase gene gene1406 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01407 S101447_01408 S101447_01408 S101447_01408 1427006 1427956 - hypothetical protein gene gene1407 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01408 S101447_01409 S101447_01409 S101447_01409 1428498 1430006 + hypothetical protein gene gene1408 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01409 S101447_01410 S101447_01410 S101447_01410 1430152 1430370 + hypothetical protein gene gene1409 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01410 S101447_01411 S101447_01411 S101447_01411 1430394 1431128 + hypothetical protein gene gene1410 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01411 S101447_01412 S101447_01412 S101447_01412 1431314 1432894 - hypothetical protein gene gene1411 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01412 S101447_01413 S101447_01413 S101447_01413 1433059 1433580 - UPF0423 protein Signal%3B Belongs to the UPF0423 family gene gene1412 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01413 S101447_01414 S101447_01414 S101447_01414 1433644 1434465 - uncharacterized protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9. A. 10. 1) family gene gene1413 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01414 S101447_01415 S101447_01415 S101447_01415 1434469 1434813 - uncharacterized protein Membrane%3B Transmembrane%3B Transmembrane helix. gene gene1414 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01415 S101447_01416 S101447_01416 S101447_01416 1434903 1435433 + hypothetical protein gene gene1415 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01416 S101447_01417 S101447_01417 thiC thiC 1435509 1437386 - Phosphomethylpyrimidine synthase 4Fe-4S%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding%3B S-adenosyl-L-methionine%3B Thiamine biosynthesis%3B Zinc%3B Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction%3B Belongs to the ThiC family%3B KEGG: apt:APA01_25230 phosphomethylpyrimidine synthase gene gene1416 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01417 S101447_01418 S101447_01418 S101447_01418 1437795 1439282 + Solute carrier family 2%2C facilitated glucose transporter member Cytoplasm%3B Glycoprotein%3B Membrane%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Facilitative glucose transporter%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family. Glucose transporter subfamily gene gene1417 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01418 S101447_01419 S101447_01419 S101447_01419 1439382 1440725 - Urea carboxylase ATP-binding%3B Biotin%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Ligase%3B Lipid biosynthesis%3B Lipid metabolism%3B Nucleotide-binding%3B This protein is a component of the acetyl coenzyme A carboxylase comple%3B first%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA%3B Contains 1 ATP-grasp domain%3B Contains 1 biotin carboxylation domain%3B KEGG: eas:Entas_1995 urea carboxylase gene gene1418 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01419 S101447_01420 S101447_01420 S101447_01420 1440725 1441198 - Biotin carboxyl carrier protein of acetyl-CoA carboxylase Biotin%3B Chloroplast%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Plastid%3B This protein is a component of the acetyl coenzyme A carboxylase comple%3B first%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA%3B Contains 1 biotinyl-binding domain gene gene1419 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01420 S101447_01421 S101447_01421 aroQ aroQ 1441198 1441671 - 3-dehydroquinate dehydratase Lyase%3B Quinate metabolism%3B Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway%3B Belongs to the type-II 3-dehydroquinase family%3B KEGG: apt:APA01_25190 3-dehydroquinate dehydratase II gene gene1420 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01421 S101447_01422 S101447_01422 S101447_01422 1441911 1442504 + RlpA-like lipoprotein Cell membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Belongs to the RlpA family gene gene1421 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01422 S101447_01423 S101447_01423 S101447_01423 1442603 1443583 - Putative ribonuclease-like protein YfkH Cell membrane%3B Exonuclease%3B Hydrolase%3B Membrane%3B Nuclease%3B Transmembrane%3B Transmembrane helix. gene gene1422 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01423 S101447_01424 S101447_01424 odc1 odc1 1444040 1445170 + Ornithine decarboxylase Decarboxylase%3B Lyase%3B Polyamine biosynthesis%3B Putrescine biosynthesis%3B Pyridoxal phosphate%3B Spermidine biosynthesis%3B Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency. Belongs to the Orn/Lys/Arg decarboxylase class-II family%3B KEGG: pla:Plav_3234 ornithine decarboxylase gene gene1423 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01424 S101447_01425 S101447_01425 S101447_01425 1445286 1446005 + hypothetical protein gene gene1424 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01425 S101447_01426 S101447_01426 S101447_01426 1446074 1446742 - Heme exporter protein Cell inner membrane%3B Cell membrane%3B Cytochrome c-type biogenesis%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. Belongs to the CcmB/CycW/HelB family gene gene1425 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01426 S101447_01427 S101447_01427 ccmA ccmA 1446739 1447296 - Heme-transporting ATPase ATP-binding%3B Cytochrome c-type biogenesis%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochrome%3B once thought to export heme%2C this seems not to be the case%2C but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily. ABCI family%3B Contains 1 ABC transporter domain%3B KEGG: eco:b2201 heme exporter protein A gene gene1426 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01427 S101447_01428 S101447_01428 acnA acnA 1447677 1450370 + Aconitate hydratase 4Fe-4S%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding%3B RNA-binding%3B Tricarboxylic acid cycle%3B Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2- methyl-cis-aconitate to yield (2R%2C3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein%3B Belongs to the aconitase/IPM isomerase family%3B KEGG: apt:APA01_25120 aconitate hydratase gene gene1427 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01428 S101447_01429 S101447_01429 pstB pstB 1450435 1451196 + Phosphate-transporting ATPase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Phosphate transport%3B Transport%3B Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphate importer (TC 3. A. 1. 7) family%3B Contains 1 ABC transporter domain%3B KEGG: dal:Dalk_1430 phosphate transport system ATP-binding protein gene gene1428 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01429 S101447_01430 S101447_01430 S101447_01430 1451193 1452752 + putative histidine-binding protein Amino-acid transport%3B Cell membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Transport%3B Involved in histidine transport%3B Belongs to the bacterial solute-binding protein 3 family gene gene1429 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01430 S101447_01431 S101447_01431 S101447_01431 1452928 1453878 + HTH-type transcriptional activator AllS Activator%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Positive regulator essential for the expression of AllD operon. Binds to the AllD promoter (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1430 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01431 S101447_01432 S101447_01432 S101447_01432 1453918 1454886 - hypothetical protein gene gene1431 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01432 S101447_01433 S101447_01433 S101447_01433 1454930 1456213 - ClpA like protein ATP-binding%3B Chaperone%3B Nucleotide-binding%3B Repeat%3B Belongs to the ClpA/ClpB family gene gene1432 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01433 S101447_01434 S101447_01434 S101447_01434 1456210 1456806 - hypothetical protein gene gene1433 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01434 S101447_01435 S101447_01435 S101447_01435 1457040 1457645 + Ribosome maturation factor RimP Cytoplasm%3B Ribosome biogenesis%3B Required for maturation of 30S ribosomal subunits%3B Belongs to the RimP family gene gene1434 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01435 S101447_01436 S101447_01436 S101447_01436 1457676 1459220 + Transcription termination/antitermination protein NusA Cytoplasm%3B RNA-binding%3B Transcription%3B Transcription antitermination%3B Transcription regulation%3B Transcription termination%3B Participates in both transcription termination and antitermination%3B Belongs to the NusA family%3B Contains 1 KH domain%3B Contains 1 S1 motif domain gene gene1435 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01436 S101447_01437 S101447_01437 S101447_01437 1459234 1459884 + hypothetical protein gene gene1436 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01437 S101447_01438 S101447_01438 S101447_01438 1459881 1462550 + Translation initiation factor IF-2 Cytoplasm%3B GTP-binding%3B Initiation factor%3B Nucleotide-binding%3B Protein biosynthesis%3B One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene1437 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01438 S101447_01439 S101447_01439 S101447_01439 1462547 1463011 + Ribosome-binding factor Cytoplasm%3B rRNA processing%3B Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA%3B Belongs to the RbfA family gene gene1438 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01439 S101447_01440 S101447_01440 S101447_01440 1463016 1463468 - putative HTH-type transcriptional regulator YezC DNA-binding%3B Transcription%3B Transcription regulation%3B Contains 1 HTH asnC-type DNA-binding domain gene gene1439 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01440 S101447_01441 S101447_01441 S101447_01441 1463636 1464742 + Alanine racemase Isomerase%3B Pyridoxal phosphate%3B Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA%3B Belongs to the alanine racemase family%3B KEGG: goh:B932_0941 alanine racemase gene gene1440 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01441 S101447_01442 S101447_01442 S101447_01442 1464773 1466032 + D-arginine dehydrogenase FAD%3B Flavoprotein%3B Oxidoreductase%3B Catalyzes the oxidative deamination of D-amino acids. Has very broad substrate specificit%3B all the D-amino acids tested can be used as the substrate except D-Glu and D-Gln. Participates in the utilization of several D-amino acids as the sole source of nitrogen%2C i. e. D-alanine%2C D-histidine%2C D-phenylalanine%2C D-serine%2C D-threonine%2C and D-valine%3B Belongs to the DadA oxidoreductase family%3B KEGG: eco:b1189 D-amino-acid dehydrogenase gene gene1441 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01442 S101447_01443 S101447_01443 S101447_01443 1466283 1467815 + hypothetical protein gene gene1442 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01443 S101447_01444 S101447_01444 S101447_01444 1467864 1468256 - Lactoylglutathione lyase Belongs to the glyoxalase I family%3B KEGG: zmo:ZMO0030 lactoylglutathione lyase gene gene1443 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01444 S101447_01445 S101447_01445 fumA fumA 1468316 1469968 - Fumarate hydratase 4Fe-4S%3B Iron%3B Iron-sulfur%3B Isomerase%3B Lyase%3B Metal-binding%3B Tricarboxylic acid cycle%3B Catalyzes the reversible hydration of fumarate to (S)- malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80%25 of the fumarase activity when the bacteria grow aerobically. To a lesser extent%2C also displays D-tartrate dehydratase activity in vitro%2C but is not able to convert (R)-malate%2C L-tartrate or meso- tartrate. Can also catalyze the isomerization of enol- to keto- oxaloacetate%3B Belongs to the class-I fumarase family%3B KEGG: apt:APA01_24940 fumarate hydratase%2C class I gene gene1444 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01445 S101447_01446 S101447_01446 S101447_01446 1470015 1470551 - hypothetical protein gene gene1445 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01446 S101447_01447 S101447_01447 S101447_01447 1470693 1470995 + hypothetical protein gene gene1446 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01447 S101447_01448 S101447_01448 thyX thyX 1471165 1472073 + Thymidylate synthase (FAD) FAD%3B Flavoprotein%3B Methyltransferase%3B NADP%3B Nucleotide biosynthesis%3B Transferase%3B Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate%3B Belongs to the thymidylate synthase ThyX family%3B Contains 1 thyX (flavin-dependent thymidylate synthase) domain%3B KEGG: acr:Acry_0045 thymidylate synthase (FAD) gene gene1447 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01448 S101447_01449 S101447_01449 S101447_01449 1472096 1472374 + hypothetical protein gene gene1448 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01449 S101447_01450 S101447_01450 S101447_01450 1472511 1472780 + hypothetical protein gene gene1449 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01450 S101447_01451 S101447_01451 S101447_01451 1472855 1473970 - Iron-sulfur cluster carrier protein ATP-binding%3B Hydrolase%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Nucleotide-binding%3B Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP%3B Belongs to the Mrp/NBP35 ATP-binding proteins family gene gene1450 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01451 S101447_01452 S101447_01452 S101447_01452 1474129 1475340 + hypothetical protein gene gene1451 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01452 S101447_01453 S101447_01453 S101447_01453 1475512 1475694 + hypothetical protein gene gene1452 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01453 S101447_01454 S101447_01454 S101447_01454 1475982 1477505 + Peptidase Do Hydrolase%3B Periplasm%3B Protease%3B Repeat%3B Serine protease%3B Signal%3B Stress response%3B Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions%3B Belongs to the peptidase S1C family%3B Contains 2 PDZ (DHR) domains%3B KEGG: apt:APA01_24860 serine protease Do gene gene1453 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01454 S101447_01455 S101447_01455 S101447_01455 1477506 1478534 + hypothetical protein gene gene1454 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01455 S101447_01456 S101447_01456 cryZ cryZ 1478649 1479632 + NADPH:quinone reductase Cytoplasm%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Zinc%3B Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent%3B Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily%3B KEGG: apt:APA01_24830 NADPH2:quinone reductase gene gene1455 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01456 S101447_01457 S101447_01457 S101447_01457 1480077 1480802 + hypothetical protein gene gene1456 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01457 S101447_01458 S101447_01458 ilvD ilvD 1480930 1482798 - Dihydroxy-acid dehydratase 4Fe-4S%3B Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding%3B Belongs to the IlvD/Edd family%3B KEGG: scl:sce5328 dihydroxy-acid dehydratase gene gene1457 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01458 S101447_01459 S101447_01459 S101447_01459 1483063 1484046 + Phosphate transport system permease protein PstC Cell inner membrane%3B Cell membrane%3B Membrane%3B Phosphate transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of a binding-protein-dependent transport system for phosphat%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1458 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01459 S101447_01460 S101447_01460 S101447_01460 1484049 1484924 + putative ABC transporter permease protein YqgI Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the binding-protein-dependent transport system YqgGHIJK. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1459 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01460 S101447_01461 S101447_01461 S101447_01461 1484921 1485751 + Phosphate-transporting ATPase Amino-acid transport%3B ATP-binding%3B Cell membrane%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of a binding-protein-dependent transport system for glutamate%2C glutamine%2C aspartate%2C asparagine. Probably responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B KEGG: apt:APA01_24770 phosphate transport system ATP-binding protein gene gene1460 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01461 S101447_01462 S101447_01462 S101447_01462 1485769 1486485 + uncharacterized protein Cytoplasm%3B Not know%3B probably involved in phosphate transport and/or metabolism%3B Belongs to the PhoU family gene gene1461 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01462 S101447_01463 S101447_01463 S101447_01463 1486513 1487385 - NADH:ubiquinone reductase (H(+)-translocating) KEGG: gbc:GbCGDNIH3_0964 NADH dehydrogenase gene gene1462 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01463 S101447_01464 S101447_01464 S101447_01464 1487385 1488716 - hypothetical protein gene gene1463 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01464 S101447_01465 S101447_01465 S101447_01465 1488923 1489399 + 50S ribosomal protein L13 Ribonucleoprotein%3B Ribosomal protein%3B This protein is one of the early assembly proteins of the 50S ribosomal subunit%2C although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly%3B Belongs to the ribosomal protein L13P family gene gene1464 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01465 S101447_01466 S101447_01466 S101447_01466 1489405 1489893 + 30S ribosomal protein S9 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein S9P family gene gene1465 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01466 S101447_01467 S101447_01467 S101447_01467 1489961 1491541 - hypothetical protein gene gene1466 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01467 S101447_01468 S101447_01468 S101447_01468 1491711 1492211 + hypothetical protein gene gene1467 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01468 S101447_01469 S101447_01469 deaD deaD 1492273 1494033 - RNA helicase ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B RNA-binding%3B Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: apt:APA01_24690 ATP-dependent RNA helicase DeaD gene gene1468 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01469 S101447_01470 S101447_01470 S101447_01470 1494155 1496029 - hypothetical protein gene gene1469 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01470 S101447_01471 S101447_01471 S101447_01471 1496255 1496656 + Lactoylglutathione lyase KEGG: ete:ETEE_3600 lactoylglutathione lyase gene gene1470 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01471 S101447_01472 S101447_01472 dapF dapF 1496762 1497574 + Diaminopimelate epimerase Amino-acid biosynthesis%3B Cytoplasm%3B Disulfide bond%3B Isomerase%3B Lysine biosynthesis%3B Catalyzes the stereoinversion of LL-2%2C6- diaminoheptanedioate (L%2CL-DAP) to meso-diaminoheptanedioate (meso- DAP)%2C a precursor of L-lysine and an essential component of the bacterial peptidoglycan%3B Belongs to the diaminopimelate epimerase family%3B KEGG: apt:APA01_24660 diaminopimelate epimerase gene gene1471 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01472 S101447_01473 S101447_01473 mtaB mtaB 1497571 1498815 + tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase 4Fe-4S%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B S-adenosyl-L-methionine%3B Transferase%3B tRNA processing%3B Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A)%2C leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine%3B Belongs to the methylthiotransferase family. MtaB subfamily%3B Contains 1 MTTase N-terminal domain%3B KEGG: gxy:GLX_24610 threonylcarbamoyladenosine tRNA methylthiotransferase MtaB gene gene1472 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01473 S101447_01474 S101447_01474 S101447_01474 1498817 1499746 + Signal recognition particle receptor FtsY Cell inner membrane%3B Cell membrane%3B Cytoplasm%3B GTP-binding%3B Membrane%3B Nucleotide-binding%3B Receptor%3B Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane%2C the hydrolysis of GTP by both Ffh and FtsY%2C and the dissociation of the SRP-FtsY complex into the individual components%3B Belongs to the GTP-binding SRP family. FtsY subfamily gene gene1473 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01474 S101447_01475 S101447_01475 S101447_01475 1499763 1499873 + hypothetical protein gene gene1474 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01475 S101447_01476 S101447_01476 S101447_01476 1499866 1500168 + ATP synthase protein Cell membrane%3B CF(0)%3B Hydrogen ion transport%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex. Belongs to the bacterial AtpI family gene gene1475 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01476 S101447_01477 S101447_01477 S101447_01477 1500224 1500973 + ATP synthase subunit ATP synthesis%3B Cell inner membrane%3B Cell membrane%3B CF(0)%3B Hydrogen ion transport%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Key component of the proton channe%3B it plays a direct role in the translocation of protons across the membrane%3B Belongs to the ATPase A chain family gene gene1476 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01477 S101447_01478 S101447_01478 S101447_01478 1501029 1501253 + ATP synthase subunit ATP synthesis%3B Cell inner membrane%3B Cell membrane%3B CF(0)%3B Hydrogen ion transport%3B Ion transport%3B Lipid-binding%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B Key component of the F(0) channe%3B it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits%3B Belongs to the ATPase C chain family gene gene1477 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01478 S101447_01479 S101447_01479 S101447_01479 1501285 1501884 + ATP synthase subunit b ATP synthesis%3B Cell inner membrane%3B Cell membrane%3B CF(0)%3B Hydrogen ion transport%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B Component of the F(0) channel%2C it forms part of the peripheral stalk%2C linking F(1) to F(0)%3B Belongs to the ATPase B chain family gene gene1478 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01479 S101447_01480 S101447_01480 S101447_01480 1501908 1502411 + ATP synthase subunit b ATP synthesis%3B Cell inner membrane%3B Cell membrane%3B CF(0)%3B Hydrogen ion transport%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B Component of the F(0) channel%2C it forms part of the peripheral stalk%2C linking F(1) to F(0)%3B Belongs to the ATPase B chain family gene gene1479 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01480 S101447_01481 S101447_01481 dpm1 dpm1 1502438 1503211 + Dolichyl-phosphate beta-D-mannosyltransferase Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Glycosyltransferase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Lipopolysaccharide biosynthesis%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides%3B Belongs to the glycosyltransferase 2 family%3B KEGG: apt:APA01_24580 dolichol-phosphate mannosyltransferase gene gene1480 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01481 S101447_01482 S101447_01482 S101447_01482 1503205 1504896 + hypothetical protein gene gene1481 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01482 S101447_01483 S101447_01483 S101447_01483 1504982 1505054 - tRNA-Thr tRNA gene1482 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01483 S101447_01484 S101447_01484 S101447_01484 1505232 1506695 + Inner membrane protein YebS Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the PqiA family gene gene1483 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01484 S101447_01485 S101447_01485 S101447_01485 1506665 1508401 + Paraquat-inducible protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the PqiB family gene gene1484 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01485 S101447_01486 S101447_01486 S101447_01486 1508406 1509104 + hypothetical protein gene gene1485 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01486 S101447_01487 S101447_01487 purF purF 1509187 1510674 - Amidophosphoribosyltransferase Glutamine amidotransferase%3B Glycosyltransferase%3B Magnesium%3B Metal-binding%3B Purine biosynthesis%3B Transferase%3B Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine%3B In the C-terminal sectio%3B belongs to the purine/pyrimidine phosphoribosyltransferase family%3B Contains 1 glutamine amidotransferase type-2 domain%3B KEGG: apt:APA01_24520 amidophosphoribosyltransferase gene gene1486 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01487 S101447_01488 S101447_01488 S101447_01488 1510721 1511245 - hypothetical protein gene gene1487 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01488 S101447_01489 S101447_01489 S101447_01489 1511297 1511647 - Phosphoribosyl-ATP diphosphatase KEGG: gxl:H845_2953 phosphoribosyl-ATP pyrophosphohydrolase gene gene1488 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01489 S101447_01490 S101447_01490 metH metH 1511669 1515175 - Methionine synthase Amino-acid biosynthesis%3B Cobalamin%3B Cobalt%3B Metal-binding%3B Methionine biosynthesis%3B Methyltransferase%3B Repeat%3B S-adenosyl-L-methionine%3B Transferase%3B Zinc%3B Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine%2C yielding enzyme-bound cob(I)alamin and methionine. Subsequently%2C remethylates the cofactor using methyltetrahydrofolate (By similarity)%3B Belongs to the vitamin-B12 dependent methionine synthase family%3B Contains 1 AdoMet activation domain%3B Contains 1 B12-binding domain%3B Contains 1 B12-binding N-terminal domain%3B Contains 1 Hcy-binding domain%3B Contains 1 pterin-binding domain%3B KEGG: apt:APA01_24490 5-methyltetrahydrofolate--homocysteine methyltransferase gene gene1489 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01490 S101447_01491 S101447_01491 S101447_01491 1515265 1515657 + hypothetical protein gene gene1490 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01491 S101447_01492 S101447_01492 S101447_01492 1515840 1518095 + Alpha-hemolysin translocation ATP-binding protein HlyB ATP-binding%3B Cell membrane%3B Cytolysis%3B Hemolysis%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the export of hemolysin A. Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3. A. 1. 109) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B Contains 1 peptidase C39 domain gene gene1491 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01492 S101447_01493 S101447_01493 S101447_01493 1518100 1519566 + Hemolysin secretion protein D%2C chromosomal Cell inner membrane%3B Cell membrane%3B Cytolysis%3B Hemolysis%3B Membrane%3B Signal-anchor%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the transport of hemolysin A. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene1492 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01493 S101447_01494 S101447_01494 S101447_01494 1519614 1521386 + Secretory immunoglobulin A-binding protein EsiB Magnesium%3B Metal-binding%3B Repeat%3B Signal%3B Virulence%3B Upon host (human neutrophil) infection interferes with productive FCAR signaling%2C inhibiting secreted IgA (SIgA) effector functions and probably avoiding neutrophil activation. Inhibits the SIgA-mediated oxidative burst by neutrophils%2C decreases generation of ROS (reactive oxygen species) by neutrophils and reduces chemotaxis by neutrophils%2C all of which are SIgA effector functions used to stimulate the immune response. Does not block SIgA-binding to its receptor (FCAR) on neutrophils%2C but it decreases SIgA-stimulated phosphorylation of cytoplasmic proteins%2C including phospholipase C-gamma and MAP kinases%2C all actions that may be advantageous to the pathogen%3B Contains 11 Sel1-like repeats gene gene1493 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01494 S101447_01495 S101447_01495 S101447_01495 1521459 1524539 + hypothetical protein gene gene1494 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01495 S101447_01496 S101447_01496 S101447_01496 1524609 1525754 + hypothetical protein gene gene1495 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01496 S101447_01497 S101447_01497 S101447_01497 1525833 1527278 + hypothetical protein gene gene1496 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01497 S101447_01498 S101447_01498 S101447_01498 1527344 1527934 - hypothetical protein gene gene1497 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01498 S101447_01499 S101447_01499 S101447_01499 1527931 1528887 - hypothetical protein gene gene1498 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01499 S101447_01500 S101447_01500 S101447_01500 1528893 1529678 - Monosaccharide-transporting ATPase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Phosphate transport%3B Transport%3B Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphate importer (TC 3. A. 1. 7) family%3B Contains 1 ABC transporter domain%3B KEGG: vfu:vfu_A00397 simple sugar transport system ATP-binding protein gene gene1499 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01500 S101447_01501 S101447_01501 S101447_01501 1529678 1530835 - Protein TRIGALACTOSYLDIACYLGLYCEROL 1%2C chloroplastic Chloroplast%3B Lipid transport%3B Membrane%3B Plastid%3B Plastid inner membrane%3B Transit peptide%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Required during embryogenesis. Permease involved in lipid transfer from the endoplasmic reticulum (ER) to plastids%2C and necessary for thylakoids formation%3B Belongs to the MlaE permease family gene gene1500 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01501 S101447_01502 S101447_01502 truB truB 1531138 1532055 + tRNA pseudouridine(55) synthase Isomerase%3B tRNA processing%3B Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs%3B Belongs to the pseudouridine synthase TruB family. Type 1 subfamily%3B KEGG: cja:CJA_0438 tRNA pseudouridine55 synthase gene gene1501 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01502 S101447_01503 S101447_01503 S101447_01503 1532087 1532356 + 30S ribosomal protein S15 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA%3B Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome%3B Belongs to the ribosomal protein S15P family gene gene1502 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01503 S101447_01504 S101447_01504 S101447_01504 1532634 1534784 + Polyribonucleotide nucleotidyltransferase Cytoplasm%3B Magnesium%3B Metal-binding%3B Nucleotidyltransferase%3B RNA-binding%3B Transferase%3B Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction%3B Belongs to the polyribonucleotide nucleotidyltransferase family%3B Contains 1 KH domain%3B Contains 1 S1 motif domain%3B KEGG: gox:GOX1586 polyribonucleotide nucleotidyltransferase gene gene1503 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01504 S101447_01505 S101447_01505 S101447_01505 1534844 1536262 + hypothetical protein gene gene1504 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01505 S101447_01506 S101447_01506 S101447_01506 1536350 1536535 - hypothetical protein gene gene1505 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01506 S101447_01507 S101447_01507 gyrA gyrA 1536802 1539495 + DNA topoisomerase (ATP-hydrolyzing) ATP-binding%3B Cytoplasm%3B DNA-binding%3B Isomerase%3B Nucleotide-binding%3B Topoisomerase%3B DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings%3B Belongs to the topoisomerase GyrA/ParC subunit family%3B KEGG: rso:RSc0901 DNA gyrase subunit A gene gene1506 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01507 S101447_01508 S101447_01508 coaD coaD 1539492 1540031 + Pantetheine-phosphate adenylyltransferase ATP-binding%3B Coenzyme A biosynthesis%3B Cytoplasm%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase%3B Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine%2C yielding dephospho-CoA (dPCoA) and pyrophosphate%3B Belongs to the bacterial CoaD family%3B KEGG: apt:APA01_24310 pantetheine-phosphate adenylyltransferase gene gene1507 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01508 S101447_01509 S101447_01509 ppiB ppiB 1540073 1540564 + Peptidylprolyl isomerase Chaperone%3B Cyclosporin%3B Isomerase%3B Nucleus%3B Repeat%3B Rotamase%3B WD repeat%3B PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Histone remodeling factor involved in chromatin- based gene silencing. Reinforces H3K27 methylation. Involved in fundamental processes of chromatin assembly and histone modification by mediating the targeting of FAS1 and LHP1 on the chromatin. Required for the formation and development of leaves%2C for normal phyllotaxy and for the formation%2C maintenance and activity of root and shoot apical meristems%3B Belongs to the cyclophilin-type PPIase family%3B Contains 1 PPIase cyclophilin-type domain%3B Contains 4 WD repeats%3B KEGG: gbm:Gbem_1339 peptidyl-prolyl cis-trans isomerase B (cyclophilin B) gene gene1508 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01509 S101447_01510 S101447_01510 S101447_01510 1540753 1540828 + tRNA-Lys tRNA gene1509 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01510 S101447_01511 S101447_01511 S101447_01511 1540881 1541798 - putative HTH-type transcriptional regulator in ibpB-leuC intergenic region DNA-binding%3B Transcription%3B Transcription regulation%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1510 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01511 S101447_01512 S101447_01512 S101447_01512 1541899 1544289 + hypothetical protein gene gene1511 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01512 S101447_01513 S101447_01513 speD speD 1544345 1544911 + Adenosylmethionine decarboxylase Autocatalytic cleavage%3B Decarboxylase%3B Lyase%3B Polyamine biosynthesis%3B Pyruvate%3B S-adenosyl-L-methionine%3B Schiff base%3B Spermidine biosynthesis%3B Zymogen%3B Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet)%2C the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine%3B Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily%3B KEGG: acr:Acry_2192 S-adenosylmethionine decarboxylase gene gene1512 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01513 S101447_01514 S101447_01514 speE speE 1544985 1545893 + Spermidine synthase Cytoplasm%3B Polyamine biosynthesis%3B Spermidine biosynthesis%3B Transferase%3B Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1%2C4-diaminobutane) to yield spermidine%3B Belongs to the spermidine/spermine synthase family%3B Contains 1 PABS (polyamine biosynthesis) domain%3B KEGG: apk:APA386B_1228 spermidine synthase gene gene1513 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01514 S101447_01515 S101447_01515 gcvT gcvT 1546191 1547327 + Aminomethyltransferase Aminotransferase%3B Mitochondrion%3B Transferase%3B Transit peptide%3B The glycine decarboxylase (GDC) or glycine cleavage system catalyzes the degradation of glycine%3B Belongs to the GcvT family%3B KEGG: apt:APA01_24240 aminomethyltransferase gene gene1514 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01515 S101447_01516 S101447_01516 S101447_01516 1547373 1547738 + Glycine cleavage system H protein Lipoyl%3B The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein%3B Belongs to the GcvH family%3B Contains 1 lipoyl-binding domain gene gene1515 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01516 S101447_01517 S101447_01517 gldC gldC 1547803 1550721 + Glycine dehydrogenase (aminomethyl-transferring) Oxidoreductase%3B Pyridoxal phosphate%3B The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofacto%3B CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein%3B Belongs to the GcvP family%3B KEGG: apt:APA01_24220 glycine dehydrogenase gene gene1516 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01517 S101447_01518 S101447_01518 S101447_01518 1550888 1551637 - hypothetical protein gene gene1517 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01518 S101447_01519 S101447_01519 ridA ridA 1551955 1552305 - 2-iminobutanoate/2-iminopropanoate deaminase Belongs to the RutC family%3B KEGG: syp:SYNPCC7002_A0617 2-iminobutanoate/2-iminopropanoate deaminase gene gene1518 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01519 S101447_01520 S101447_01520 mocA mocA 1552394 1552930 - Molybdenum cofactor cytidylyltransferase KEGG: apt:APA01_24190 molybdenum cofactor cytidylyltransferase gene gene1519 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01520 S101447_01521 S101447_01521 S101447_01521 1553038 1554129 - uncharacterized protein gene gene1520 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01521 S101447_01522 S101447_01522 S101447_01522 1554254 1554667 + hypothetical protein gene gene1521 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01522 S101447_01523 S101447_01523 S101447_01523 1554782 1555453 + Hydroxyacylglutathione hydrolase Hydrolase%3B Metal-binding%3B Zinc%3B Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family%3B KEGG: pha:PSHAa1401 hydroxyacylglutathione hydrolase gene gene1522 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01523 S101447_01524 S101447_01524 S101447_01524 1555477 1555980 + hypothetical protein gene gene1523 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01524 S101447_01525 S101447_01525 S101447_01525 1556066 1557040 + UDP-glucuronate 4-epimerase Carbohydrate metabolism%3B Golgi apparatus%3B Isomerase%3B Membrane%3B NAD%3B Transmembrane%3B Transmembrane helix%3B Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: pmr:PMI1489 UDP-glucuronate 4-epimerase gene gene1524 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01525 S101447_01526 S101447_01526 S101447_01526 1557448 1558935 + 16S ribosomal RNA rRNA gene1525 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01526 S101447_01527 S101447_01527 S101447_01527 1559151 1559227 + tRNA-Ile tRNA gene1526 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01527 S101447_01528 S101447_01528 S101447_01528 1559252 1559327 + tRNA-Ala tRNA gene1527 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01528 S101447_01529 S101447_01529 S101447_01529 1559659 1562401 + 23S ribosomal RNA rRNA gene1528 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01529 S101447_01530 S101447_01530 S101447_01530 1562510 1562625 + 5S ribosomal RNA rRNA gene1529 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01530 S101447_01531 S101447_01531 S101447_01531 1562681 1562757 + tRNA-Met tRNA gene1530 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01531 S101447_01532 S101447_01532 S101447_01532 1563201 1563653 + HTH-type transcriptional repressor NicR Aromatic hydrocarbons catabolism%3B DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Transcriptional repressor for the nicCDEFTP and nicXR operons%2C encoding the lower aerobic nicotinate degradation pathway. Acts under non-induced conditions: repression of the nicCDEFTP and nicXR operons becomes alleviated in presence of 6- hydroxynicotinate (6HNA)%3B Contains 1 HTH marR-type DNA-binding domain gene gene1531 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01532 S101447_01533 S101447_01533 nicC nicC 1563960 1565084 + 6-hydroxynicotinate 3-monooxygenase Aromatic hydrocarbons catabolism%3B FAD%3B Flavoprotein%3B Monooxygenase%3B NAD%3B NADP%3B Oxidoreductase%3B Catalyzes the NAD- or NADP-dependent conversion of 3- hydroxybenzoate to gentisate. The affinity of the enzyme toward NAD is twice as high as for NADP. Belongs to the 3-hydroxybenzoate 6-hydroxylase family%3B KEGG: goy:GLS_c14190 6-hydroxynicotinate 3-monooxygenase gene gene1532 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01533 S101447_01534 S101447_01534 nicA nicA 1565108 1565590 + Nicotinate dehydrogenase (cytochrome) 2Fe-2S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase%3B Specific towards N-containing N-heterocyclic substrates%2C including isoquinoline%2C isoquinolin-5-ol%2C phthalazine and quinazoline. Contains 1 2Fe-2S ferredoxin-type domain%3B KEGG: apt:APA01_23780 nicotinate dehydrogenase subunit A%3B overlaps another CDS with the same product name gene gene1533 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01534 S101447_01535 S101447_01535 S101447_01535 1565587 1569159 + Nicotinate dehydrogenase (cytochrome) Aromatic hydrocarbons catabolism%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Molybdenum%3B Oxidoreductase%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Subunit of the two-component enzyme NicAB that mediates nicotinate hydroxylation%2C the first step in the aerobic nicotinate degradation pathway. Mediates conversion of nicotinate into 6- hydroxynicotinate (6HNA)%3B Contains 3 cytochrome c domains%3B KEGG: apt:APA01_23770 nicotinate dehydrogenase subunit B%3B overlaps another CDS with the same product name gene gene1534 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01535 S101447_01536 S101447_01536 nicX nicX 1569227 1570264 + 2%2C5-dihydroxypyridine 5%2C6-dioxygenase Aromatic hydrocarbons catabolism%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Catalyzes the dioxygenolytic ring cleavage of 2%2C5- dihydroxypyridine between carbons 5 and 6 generating N- formylmaleamate in the aerobic nicotinate degradation pathway%3B KEGG: ppu:PP_3945 2%2C5-dihydroxypyridine 5%2C6-dioxygenase gene gene1535 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01536 S101447_01537 S101447_01537 nicF nicF 1570264 1570896 + Maleamate amidohydrolase Aromatic hydrocarbons catabolism%3B Hydrolase%3B Maleamate amidase that transforms maleamate into maleate and ammonia in the aerobic nicotinate degradation pathway%3B Belongs to the isochorismatase family%3B KEGG: goy:GLS_c14240 maleamate amidohydrolase gene gene1536 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01537 S101447_01538 S101447_01538 nicD nicD 1570918 1571712 + N-formylmaleamate deformylase Aromatic hydrocarbons catabolism%3B Hydrolase%3B Deformylase that catalyzes the conversion of N- formylmaleamic acid to maleamate in the aerobic nicotinate degradation pathway%3B KEGG: apt:APA01_23740 N-formylmaleamate deformylase gene gene1537 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01538 S101447_01539 S101447_01539 nicE nicE 1571807 1572559 + Maleate isomerase Aromatic hydrocarbons catabolism%3B Isomerase%3B Catalyzes the conversion of maleate to fumarate in the aerobic nicotinate degradation pathway%3B Belongs to the aspartate/glutamate racemases family. Maleate isomerase subfamily%3B KEGG: ppg:PputGB1_3577 maleate isomerase gene gene1538 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01539 S101447_01540 S101447_01540 S101447_01540 1572969 1574276 + Putative metabolite transport protein NicT Aromatic hydrocarbons catabolism%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Probable transporter%2C possibly involved in the aerobic nicotinate degradation pathway%3B Belongs to the major facilitator superfamily gene gene1539 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01540 S101447_01541 S101447_01541 S101447_01541 1574399 1575985 + hypothetical protein gene gene1540 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01541 S101447_01542 S101447_01542 S101447_01542 1576075 1576998 - HTH-type transcriptional regulator YidZ DNA-binding%3B Transcription%3B Transcription regulation%3B Involved in anaerobic NO protection%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1541 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01542 S101447_01543 S101447_01543 S101447_01543 1577119 1578756 + putative MFS-type transporter YcnB Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the major facilitator superfamily. EmrB family gene gene1542 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01543 S101447_01544 S101447_01544 S101447_01544 1578772 1579848 + Multidrug resistance protein MdtN Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Signal-anchor%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Could be involved in resistance to puromycin%2C acriflavine and tetraphenylarsonium chloride%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene1543 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01544 S101447_01545 S101447_01545 S101447_01545 1579817 1581376 + Cation efflux system protein CusC Cell outer membrane%3B Ion transport%3B Lipoprotein%3B Membrane%3B Palmitate%3B Porin%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver (By similarity)%3B Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene1544 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01545 S101447_01546 S101447_01546 S101447_01546 1581386 1582120 + Putative quercetin 2%2C3-dioxygenase Dioxygenase%3B Metal-binding%3B Oxidoreductase%3B Putative quercetin 2%2C3-dioxygenase%3B Belongs to the pirin family gene gene1545 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01546 S101447_01547 S101447_01547 arsC arsC 1582226 1582573 - Arsenate reductase (glutaredoxin) Arsenical resistance%3B Oxidoreductase%3B Plasmid%3B Transposable element%3B Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance (By similarity)%3B Belongs to the ArsC family%3B KEGG: pes:SOPEG_3771 arsenate reductase gene gene1546 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01547 S101447_01548 S101447_01548 S101447_01548 1582654 1584345 + Sulfate transporter 3.1 Membrane%3B Stress response%3B Sulfate transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B H(+)/sulfate cotransporter that may play a role in the regulation of sulfate assimilation. Belongs to the SLC26A/SulP transporter (TC 2. A. 53) family%3B Contains 1 STAS domain gene gene1547 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01548 S101447_01549 S101447_01549 S101447_01549 1584349 1585125 - UPF0721 transmembrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0721 family gene gene1548 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01549 S101447_01550 S101447_01550 S101447_01550 1585154 1586080 - Beta-lactamase hydrolase-like protein Hydrolase%3B Belongs to the metallo-beta-lactamase superfamily gene gene1549 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01550 S101447_01551 S101447_01551 S101447_01551 1586169 1586849 + Peroxiredoxin Antioxidant%3B Cytoplasm%3B Oxidoreductase%3B Redox-active center%3B Protects cells against oxidative stress. Can reduce hydrogen peroxide and/or alkyl hydroperoxides using dithiothreitol as an electron donor (in vitro) (By similarity)%3B Belongs to the AhpC/TSA family. TDXH subfamily%3B Contains 1 thioredoxin domain%3B KEGG: apt:APA01_23580 peroxiredoxin (alkyl hydroperoxide reductase subunit C) gene gene1550 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01551 S101447_01552 S101447_01552 S101447_01552 1586854 1587285 + Biofilm growth-associated repressor DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Represses an operon that comprises itself%2C XF_0764%2C XF_0765%2C XF_0766 and blh. Binds to a palindromic AT-rich sequence spanning the -10 region of the blh promoter and blocks transcription of the operon%3B Contains 1 HTH arsR-type DNA-binding domain gene gene1551 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01552 S101447_01553 S101447_01553 S101447_01553 1587300 1587863 + DNA-3-methyladenine glycosylase I ATP-binding%3B Glutamine amidotransferase%3B GMP biosynthesis%3B Ligase%3B Nucleotide-binding%3B Purine biosynthesis%3B Repeat%3B Catalyzes the synthesis of GMP from XMP%3B Contains 1 glutamine amidotransferase type-1 domain%3B Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain%3B Contains 3 N-acetyltransferase domains%3B KEGG: apt:APA01_23560 DNA-3-methyladenine glycosylase I gene gene1552 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01553 S101447_01554 S101447_01554 S101447_01554 1587934 1588380 + hypothetical protein gene gene1553 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01554 S101447_01555 S101447_01555 S101447_01555 1588407 1588769 + Arsenate reductase (glutaredoxin) Belongs to the ArsC family%3B KEGG: ppu:PP_1531 arsenate reductase gene gene1554 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01555 S101447_01556 S101447_01556 S101447_01556 1588819 1589304 - Ferroxidase Heme%3B Iron%3B Iron storage%3B Metal-binding%3B Oxidoreductase%3B Iron-storage protein%2C whose ferroxidase center binds Fe(2+) ions%2C oxidizes them by dioxygen to Fe(3+)%2C and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex%3B Belongs to the bacterioferritin family%3B Contains 1 ferritin-like diiron domain%3B KEGG: apt:APA01_23530 bacterioferritin gene gene1555 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01556 S101447_01557 S101447_01557 S101447_01557 1589491 1590516 - hypothetical protein gene gene1556 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01557 S101447_01558 S101447_01558 S101447_01558 1590513 1592477 - hypothetical protein gene gene1557 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01558 S101447_01559 S101447_01559 S101447_01559 1592643 1593188 + hypothetical protein gene gene1558 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01559 S101447_01560 S101447_01560 ipdC ipdC 1593510 1595186 + Indolepyruvate decarboxylase Decarboxylase%3B Lyase%3B Magnesium%3B Metal-binding%3B Phosphoprotein%3B Thiamine pyrophosphate%3B Belongs to the TPP enzyme family%3B KEGG: apt:APA01_23490 indolepyruvate decarboxylase gene gene1559 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01560 S101447_01561 S101447_01561 S101447_01561 1595254 1596288 - High-affinity nickel transport protein Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Nickel%3B Nickel transport%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B High-affinity nickel transporter responsible for nickel uptake. Necessary for high levels of activity of hydrogenase and urease. Does not transport cobalt%3B Belongs to the NiCoT transporter (TC 2. A. 52) family gene gene1560 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01561 S101447_01562 S101447_01562 S101447_01562 1596478 1597299 + Urease accessory protein UreD Chaperone%3B Cytoplasm%3B Nickel insertion%3B Required for maturation of urease via the functional incorporation of the urease nickel metallocenter%3B Belongs to the UreD family gene gene1561 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01562 S101447_01563 S101447_01563 ureA ureA 1597328 1597630 + Urease Cytoplasm%3B Hydrolase%3B In the N-terminal sectio%3B belongs to the urease gamma subunit family%3B In the C-terminal sectio%3B belongs to the urease beta subunit family%3B KEGG: ece:Z1143 urease subunit gamma%3B overlaps another CDS with the same product name gene gene1562 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01563 S101447_01564 S101447_01564 ureB ureB 1597614 1597958 + Urease Cytoplasm%3B Hydrolase%3B Belongs to the urease beta subunit family%3B KEGG: apk:APA386B_1182 urease subunit beta%3B overlaps another CDS with the same product name gene gene1563 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01564 S101447_01565 S101447_01565 ureC ureC 1597955 1599661 + Urease Cytoplasm%3B Hydrolase%3B Metal-binding%3B Nickel%3B Belongs to the urease family%3B Contains 1 urease domain%3B KEGG: apt:APA01_23440 urease subunit alpha%3B overlaps another CDS with the same product name gene gene1564 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01565 S101447_01566 S101447_01566 S101447_01566 1599661 1600146 + Urease accessory protein UreE Chaperone%3B Cytoplasm%3B Nickel%3B Nickel insertion%3B Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly%3B Belongs to the UreE family gene gene1565 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01566 S101447_01567 S101447_01567 S101447_01567 1600112 1600654 + Urease accessory protein UreF Chaperone%3B Cytoplasm%3B Nickel insertion%3B Required for maturation of urease via the functional incorporation of the urease nickel metallocenter%3B Belongs to the UreF family gene gene1566 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01567 S101447_01568 S101447_01568 S101447_01568 1600818 1601432 + Urease accessory protein UreG Chaperone%3B Cytoplasm%3B GTP-binding%3B Nickel insertion%3B Nucleotide-binding%3B Virulence%3B Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis%2C probably effectuated by UreG%3B Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral%3B Belongs to the SIMIBI class G3E GTPase family. UreG subfamily gene gene1567 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01568 S101447_01569 S101447_01569 S101447_01569 1601701 1602906 + hypothetical protein gene gene1568 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01569 S101447_01570 S101447_01570 S101447_01570 1602975 1603406 + hypothetical protein gene gene1569 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01570 S101447_01571 S101447_01571 S101447_01571 1603439 1604326 - Polar-differentiation response regulator DivK Cytoplasm%3B DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system%3B Essential protein that is involved in the control of cell division%2C probably through the regulation of ctrA. Its phosphorylation status is regulated by PdhS (By similarity)%3B Contains 1 response regulatory domain gene gene1570 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01571 S101447_01572 S101447_01572 S101447_01572 1604323 1607640 - Histidine protein kinase DivJ ATP-binding%3B Cell cycle%3B Cell division%3B Cell membrane%3B Differentiation%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system%3B Kinase required for the regulation of cell division and differentiation. Is part of a signal transduction pathway%2C activating PleD by phosphorylation. Contains 1 histidine kinase domain%3B KEGG: aci:ACIAD2501 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene1571 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01572 S101447_01573 S101447_01573 S101447_01573 1607780 1609120 + Aliphatic amidase expression-regulating protein Kinase%3B Repressor%3B Transferase. gene gene1572 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01573 S101447_01574 S101447_01574 S101447_01574 1609113 1610717 + High-affinity branched-chain amino acid transport system permease protein Amino-acid transport%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily%3B overlaps another CDS with the same product name gene gene1573 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01574 S101447_01575 S101447_01575 S101447_01575 1610714 1611853 + High-affinity branched-chain amino acid transport system permease protein Amino-acid transport%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane. Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily%3B overlaps another CDS with the same product name gene gene1574 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01575 S101447_01576 S101447_01576 S101447_01576 1611850 1612590 + Spermidine/putrescine import ATP-binding protein ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene1575 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01576 S101447_01577 S101447_01577 S101447_01577 1612629 1613324 + Hemin import ATP-binding protein HmuV ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3. A. 1. 14. 5) family%3B Contains 1 ABC transporter domain gene gene1576 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01577 S101447_01578 S101447_01578 S101447_01578 1613556 1613631 - tRNA-Glu tRNA gene1577 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01578 S101447_01579 S101447_01579 S101447_01579 1613807 1614163 + hypothetical protein gene gene1578 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01579 S101447_01580 S101447_01580 S101447_01580 1614172 1614606 - hypothetical protein gene gene1579 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01580 S101447_01581 S101447_01581 S101447_01581 1614651 1615805 - Coproporphyrinogen dehydrogenase 4Fe-4S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Mitochondrion%3B Oxidoreductase%3B Porphyrin biosynthesis%3B S-adenosyl-L-methionine%3B Transit peptide%3B May be involved in porphyrin cofactor biosynthesis%3B Belongs to the anaerobic coproporphyrinogen-III oxidase family%3B KEGG: apt:APA01_23250 oxygen-independent coproporphyrinogen III oxidase gene gene1580 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01581 S101447_01582 S101447_01582 S101447_01582 1615810 1617792 - putative potassium transport system protein kup Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Potassium%3B Potassium transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Transport of potassium into the cell%3B Belongs to the HAK/KUP transporter (TC 2. A. 72) family gene gene1581 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01582 S101447_01583 S101447_01583 S101447_01583 1617906 1618604 - UPF0001 protein Pyridoxal phosphate%3B Perhaps involved in proline biosynthesis. Belongs to the UPF0001 family gene gene1582 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01583 S101447_01584 S101447_01584 S101447_01584 1618749 1619780 - NADPH:quinone reductase Acetylation%3B Alternative splicing%3B NADP%3B Oxidoreductase%3B Polymorphism%3B May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity%2C with a preference for 1%2C2-beta-naphthoquinone over 1%2C4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro)%3B Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily%3B KEGG: rme:Rmet_0197 NADPH2:quinone reductase gene gene1583 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01584 S101447_01585 S101447_01585 S101447_01585 1619903 1621669 - Putative chloride channel protein ClcB-like Cell inner membrane%3B Cell membrane%3B Chloride%3B Chloride channel%3B Ion channel%3B Ion transport%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Voltage-gated channel%3B Belongs to the chloride channel (TC 2. A. 49) family. ClcB subfamily gene gene1584 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01585 S101447_01586 S101447_01586 S101447_01586 1621754 1622776 - hypothetical protein gene gene1585 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01586 S101447_01587 S101447_01587 S101447_01587 1622874 1623086 + hypothetical protein gene gene1586 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01587 S101447_01588 S101447_01588 S101447_01588 1623108 1623335 - hypothetical protein gene gene1587 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01588 S101447_01589 S101447_01589 gntK gntK 1623355 1623939 - Gluconokinase ATP-binding%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Belongs to the gluconokinase GntK/GntV family%3B KEGG: apt:APA01_23170 gluconokinase gene gene1588 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01589 S101447_01590 S101447_01590 rpiA rpiA 1623950 1624663 - Ribose-5-phosphate isomerase Isomerase%3B Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate%3B Belongs to the ribose 5-phosphate isomerase family%3B KEGG: apt:APA01_23160 ribose 5-phosphate isomerase A gene gene1589 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01590 S101447_01591 S101447_01591 pglS pglS 1624680 1625426 - 6-phosphogluconolactonase Hydrolase%3B Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily%3B KEGG: apt:APA01_23150 6-phosphogluconolactonase gene gene1590 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01591 S101447_01592 S101447_01592 S101447_01592 1625423 1626313 - Putative phosphatase Hydrolase%3B Magnesium%3B Metal-binding%3B Belongs to the HAD-like hydrolase superfamily. Cof family gene gene1591 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01592 S101447_01593 S101447_01593 gntZ gntZ 1626351 1627139 - Phosphogluconate dehydrogenase (NADP(+)-dependent%2C decarboxylating) Gluconate utilization%3B NAD%3B Oxidoreductase%3B Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2)%2C with concomitant reduction of NAD to NADH%3B Belongs to the 6-phosphogluconate dehydrogenase family%3B KEGG: fau:Fraau_2216 6-phosphogluconate dehydrogenase%3B overlaps another CDS with the same product name gene gene1592 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01593 S101447_01594 S101447_01594 S101447_01594 1627103 1627348 - Phosphogluconate dehydrogenase (NADP(+)-dependent%2C decarboxylating) Gluconate utilization%3B NAD%3B Oxidoreductase%3B Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2)%2C with concomitant reduction of NAD to NADH%3B Belongs to the 6-phosphogluconate dehydrogenase family%3B KEGG: pam:PANA_4019 6-phosphogluconate dehydrogenase%3B overlaps another CDS with the same product name gene gene1593 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01594 S101447_01595 S101447_01595 S101447_01595 1627370 1630225 - Transaldolase Cytoplasm%3B Pentose shunt%3B Schiff base%3B Transferase%3B Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway%3B Belongs to the transaldolase family. Type 2 subfamily%3B KEGG: apt:APA01_23120 transaldolase / glucose-6-phosphate isomerase gene gene1594 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01595 S101447_01596 S101447_01596 S101447_01596 1630310 1632412 - Transketolase Calcium%3B DNA recombination%3B Magnesium%3B Metal-binding%3B Thiamine pyrophosphate%3B Transferase%3B Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor%2C via a covalent intermediate with the cofactor thiamine pyrophosphate%3B Belongs to the transketolase family%3B KEGG: apt:APA01_23110 transketolase gene gene1595 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01596 S101447_01597 S101447_01597 S101447_01597 1632752 1633324 + Ankyrin-1 Alternative promoter usage%3B Alternative splicing%3B ANK repeat%3B Cytoplasm%3B Cytoskeleton%3B Disease mutation%3B Elliptocytosis%3B Hereditary hemolytic anemia%3B Hydroxylation%3B Lipoprotein%3B Membrane%3B Phosphoprotein%3B Polymorphism%3B Repeat%3B Sarcoplasmic reticulum%3B Attaches integral membrane proteins to cytoskeletal element%3B binds to the erythrocyte membrane protein band 4. 2%2C to Na-K ATPase%2C to the lymphocyte membrane protein GP85%2C and to the cytoskeletal proteins fodrin%2C tubulin%2C vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protei%3B they retain most or all of these binding functions%3B Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils%3B Contains 23 ANK repeats%3B Contains 1 death domain%3B Contains 2 ZU5 domains gene gene1596 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01597 S101447_01598 S101447_01598 hisC hisC 1633422 1634492 + Histidinol-phosphate transaminase Amino-acid biosynthesis%3B Aminotransferase%3B Histidine biosynthesis%3B Pyridoxal phosphate%3B Transferase%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily%3B KEGG: mad:HP15_2427 histidinol-phosphate aminotransferase gene gene1597 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01598 S101447_01599 S101447_01599 S101447_01599 1634669 1634956 + hypothetical protein gene gene1598 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01599 S101447_01600 S101447_01600 S101447_01600 1635103 1636164 + Zinc transport protein ZntB Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Zinc%3B Mediates efflux of zinc ions%3B Belongs to the CorA metal ion transporter (MIT) (TC 1. A. 35) family gene gene1599 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01600 S101447_01601 S101447_01601 S101447_01601 1636168 1636515 - UPF0060 membrane protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0060 family gene gene1600 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01601 S101447_01602 S101447_01602 S101447_01602 1636519 1637376 - Methionine import ATP-binding protein MetN Amino-acid transport%3B ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Methionine importer (TC 3. A. 1. 24) family%3B Contains 1 ABC transporter domain gene gene1601 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01602 S101447_01603 S101447_01603 S101447_01603 1637373 1638236 - O-antigen export system permease protein RfbD Cell inner membrane%3B Cell membrane%3B Membrane%3B Polysaccharide transport%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B May form an ATP-driven O-antigen export apparatus%2C in association with RfbE. Belongs to the ABC-2 integral membrane protein family%3B Contains 1 ABC transmembrane type-2 domain gene gene1602 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01603 S101447_01604 S101447_01604 S101447_01604 1638426 1639790 + hypothetical protein gene gene1603 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01604 S101447_01605 S101447_01605 S101447_01605 1639849 1640856 - hypothetical protein gene gene1604 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01605 S101447_01606 S101447_01606 S101447_01606 1640853 1641638 - Laccase domain protein Belongs to the LACC1 family gene gene1605 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01606 S101447_01607 S101447_01607 S101447_01607 1641635 1642618 - NADH dehydrogenase (ubiquinone) complex I%2C assembly factor Mitochondrion%3B Transit peptide%3B Involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Cells lacking midA have lower levels of ATP and no glycogen. May have methyltransferase activity%3B Belongs to the NDUFAF7 family gene gene1606 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01607 S101447_01608 S101447_01608 umpA umpA 1642672 1643511 - Prolipoprotein diacylglyceryl transferase Cell inner membrane%3B Cell membrane%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins%3B Belongs to the Lgt family%3B KEGG: gdj:Gdia_1093 phosphatidylglycerol:prolipoprotein diacylglycerol transferase%3B Transferases gene gene1607 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01608 S101447_01609 S101447_01609 gmhD gmhD 1643536 1644516 - ADP-glyceromanno-heptose 6-epimerase Carbohydrate metabolism%3B Isomerase%3B NADP%3B Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily%3B KEGG: xau:Xaut_3772 ADP-L-glycero-D-manno-heptose 6-epimerase gene gene1608 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01609 S101447_01610 S101447_01610 S101447_01610 1644666 1644968 + hypothetical protein gene gene1609 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01610 S101447_01611 S101447_01611 S101447_01611 1645054 1646646 - L-lactate permease Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B May play a role in L-lactate transport. Belongs to the lactate permease family gene gene1610 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01611 S101447_01612 S101447_01612 S101447_01612 1646879 1647079 + hypothetical protein gene gene1611 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01612 S101447_01613 S101447_01613 S101447_01613 1647163 1648167 + hypothetical protein gene gene1612 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01613 S101447_01614 S101447_01614 S101447_01614 1648247 1649647 + Arabinose-proton symporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Sugar transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system)%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family gene gene1613 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01614 S101447_01615 S101447_01615 S101447_01615 1649759 1649835 - tRNA-Arg tRNA gene1614 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01615 S101447_01616 S101447_01616 S101447_01616 1649908 1650360 - hypothetical protein gene gene1615 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01616 S101447_01617 S101447_01617 S101447_01617 1650580 1652181 + GMP synthase (glutamine-hydrolyzing) ATP-binding%3B Glutamine amidotransferase%3B GMP biosynthesis%3B Ligase%3B Nucleotide-binding%3B Purine biosynthesis%3B Catalyzes the synthesis of GMP from XMP%3B Contains 1 glutamine amidotransferase type-1 domain%3B Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain%3B KEGG: apt:APA01_22710 GMP synthase (glutamine-hydrolysing) gene gene1616 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01617 S101447_01618 S101447_01618 S101447_01618 1652254 1653294 - Cysteine synthase Amino-acid biosynthesis%3B CBS domain%3B Cysteine biosynthesis%3B Lyase%3B Pyridoxal phosphate%3B Repeat%3B Belongs to the cysteine synthase/cystathionine beta- synthase family%3B Contains 2 CBS domains%3B KEGG: apt:APA01_22700 cysteine synthase A gene gene1617 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01618 S101447_01619 S101447_01619 S101447_01619 1653398 1654321 - hypothetical protein gene gene1618 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01619 S101447_01620 S101447_01620 ybaK ybaK 1654467 1654982 - Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK Cytoplasm%3B Lyase%3B Protein biosynthesis%3B Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity. May compensate for the lack of Cys-tRNA(Pro) editing by ProRS. Is also able to deacylate Cys-tRNA(Cys)%2C and displays weak deacylase activity in vitro against Gly-tRNA(Gly)%2C as well as%2C at higher concentrations%2C some other correctly charged tRNAs. Unlike some of its orthologs it is not able to remove the amino acid moiety from incorrectly charged Ala-tRNA(Pro)%3B Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily%3B KEGG: apk:APA386B_1127 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase%3B Carboxylic ester hydrolases gene gene1619 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01620 S101447_01621 S101447_01621 mtnA mtnA 1655101 1656198 - S-methyl-5-thioribose-1-phosphate isomerase Amino-acid biosynthesis%3B Isomerase%3B Methionine biosynthesis%3B Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)%3B Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily%3B KEGG: gox:GOX1605 methylthioribose-1-phosphate isomerase gene gene1620 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01621 S101447_01622 S101447_01622 ppdK ppdK 1656517 1657236 + Pyruvate%2C phosphate dikinase Chromosome%3B DNA-binding%3B Nucleus%3B Repeat%3B Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. Belongs to the histone H1/H5 family%3B Contains 1 H15 (linker histone H1/H5 globular) domain%3B KEGG: rpx:Rpdx1_1216 pyruvate%2C orthophosphate dikinase gene gene1621 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01622 S101447_01623 S101447_01623 S101447_01623 1657474 1658016 - hypothetical protein gene gene1622 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01623 S101447_01624 S101447_01624 S101447_01624 1658049 1658459 - Zinc uptake regulation protein DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Zinc%3B Acts as a negative controlling element%2C employing Zn(2+) as a cofactor to bind the operator of the repressed genes (znuACB). Belongs to the Fur family gene gene1623 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01624 S101447_01625 S101447_01625 S101447_01625 1658710 1659612 + hypothetical protein gene gene1624 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01625 S101447_01626 S101447_01626 S101447_01626 1659612 1660418 + Nod factor export ATP-binding protein ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nodulation%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors)%2C the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide)%2C a modified beta-1%2C4-linked N-acetylglucosamine oligosaccharide. This subunit is responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Lipooligosaccharide exporter (TC 3. A. 1. 102) family%3B Contains 1 ABC transporter domain gene gene1625 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01626 S101447_01627 S101447_01627 S101447_01627 1660419 1661213 + putative metal transport system membrane protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of an ATP-driven transport system TP_0034/TP_0035/TP_0036 for a metal. Belongs to the ABC-3 integral membrane protein family gene gene1626 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01627 S101447_01628 S101447_01628 S101447_01628 1661233 1661382 - hypothetical protein gene gene1627 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01628 S101447_01629 S101447_01629 rutF rutF 1661415 1661918 - FMN reductase (NADH) RutF Flavoprotein%3B FMN%3B NAD%3B Oxidoreductase%3B Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway%3B Belongs to the non-flavoprotein flavin reductase family. RutF subfamily%3B KEGG: apt:APA01_22600 flavin reductase%3B With NAD(+) or NADP(+) as acceptor gene gene1628 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01629 S101447_01630 S101447_01630 paaF paaF 1661984 1663003 + Enoyl-CoA hydratase Alternative splicing%3B Hydrolase%3B Mitochondrion%3B Transit peptide%3B Belongs to the enoyl-CoA hydratase/isomerase family%3B KEGG: apk:APA386B_1117 enoyl-CoA hydratase gene gene1629 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01630 S101447_01631 S101447_01631 S101447_01631 1663062 1663685 - Succinate-acetate/proton symporter SatP Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Uptake of acetate and succinate. Transport is energetically dependent on the protonmotive force (By similarity)%3B Belongs to the acetate uptake transporter (AceTr) (TC 2. A. 96) family gene gene1630 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01631 S101447_01632 S101447_01632 S101447_01632 1663822 1666077 - putative transporter YdhK Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the aromatic acid exporter ArAE (TC 2. A. 85) family gene gene1631 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01632 S101447_01633 S101447_01633 S101447_01633 1666067 1666534 - Transcriptional regulator SlyA Activator%3B DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Transcription regulator that can specifically activate or repress expression of target genes%3B Belongs to the SlyA family%3B Contains 1 HTH marR-type DNA-binding domain gene gene1632 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01633 S101447_01634 S101447_01634 S101447_01634 1667158 1667586 + hypothetical protein gene gene1633 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01634 S101447_01635 S101447_01635 S101447_01635 1667583 1668635 + 47 kDa protein ATP-binding%3B Nucleotide-binding%3B The presence of P47K is critical for the expression of the nitrile hydratase genes. May stabilize or activate the nitrile hydratase proteins. Belongs to the SIMIBI class G3E GTPase family. CobW subfamily%3B Contains 1 cobW C-terminal domain gene gene1634 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01635 S101447_01636 S101447_01636 cobN cobN 1668655 1672119 + Cobaltochelatase ATP-binding%3B Cobalamin biosynthesis%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Porphyrin biosynthesis%3B Catalyzes cobalt insertion in the corrin ring. Belongs to the CobN family%3B KEGG: apt:APA01_22520 cobaltochelatase CobN gene gene1635 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01636 S101447_01637 S101447_01637 S101447_01637 1672116 1673477 + Hydrogenobyrinic acid a%2Cc-diamide synthase (glutamine-hydrolyzing) ATP-binding%3B Cobalamin biosynthesis%3B Glutamine amidotransferase%3B Ligase%3B Magnesium%3B Nucleotide-binding%3B Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate%2C using either L-glutamine or ammonia as the nitrogen source%3B Belongs to the CobB/CbiA family%3B Contains 1 GATase cobBQ-type domain%3B KEGG: apt:APA01_22510 cobyrinic acid a%2Cc-diamide synthase gene gene1636 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01637 S101447_01638 S101447_01638 S101447_01638 1673588 1674202 + Adenosylcobalamin/alpha-ribazole phosphatase KEGG: apt:APA01_22500 alpha-ribazole phosphatase gene gene1637 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01638 S101447_01639 S101447_01639 cobA cobA 1674199 1674825 + Cob(I)yrinic acid a%2Cc-diamide adenosyltransferase ATP-binding%3B Cobalamin biosynthesis%3B Cytoplasm%3B Manganese%3B Nucleotide-binding%3B Porphyrin biosynthesis%3B Transferase%3B Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity)%3B Belongs to the Cob(I)alamin adenosyltransferase family%3B KEGG: mch:Mchl_5722 cob(I)alamin adenosyltransferase gene gene1638 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01639 S101447_01640 S101447_01640 cobQ cobQ 1674822 1676360 + Adenosylcobyric acid synthase (glutamine-hydrolyzing) Cobalamin biosynthesis%3B Glutamine amidotransferase%3B Catalyzes amidations at positions B%2C D%2C E%2C and G on adenosylcobyrinic A%2CC-diamide. NH(2) groups are provided by glutamine%2C and one molecule of ATP is hydrogenolyzed for each amidation%3B Belongs to the CobB/CobQ family. CobQ subfamily%3B Contains 1 GATase cobBQ-type domain%3B KEGG: xcc:XCC3061 adenosylcobyric acid synthase gene gene1639 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01640 S101447_01641 S101447_01641 bluB bluB 1676375 1677013 - 5%2C6-dimethylbenzimidazole synthase Cobalamin biosynthesis%3B Flavoprotein%3B FMN%3B NAD%3B NADP%3B Nucleotide-binding%3B Oxidoreductase%3B Involved in the biosynthesis of cobalamin (vitamin B12)%3B Belongs to the BluB family%3B KEGG: apt:APA01_22470 5%2C6-dimethylbenzimidazole synthase gene gene1640 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01641 S101447_01642 S101447_01642 cbiB cbiB 1677010 1677957 - Adenosylcobinamide-phosphate synthase Cell membrane%3B Cobalamin biosynthesis%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group%3B Belongs to the CobD/CbiB family%3B KEGG: apt:APA01_22450 adenosylcobinamide-phosphate synthase gene gene1641 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01642 S101447_01643 S101447_01643 S101447_01643 1677998 1679116 + Threonine-phosphate decarboxylase Cobalamin biosynthesis%3B Cytoplasm%3B Lyase%3B Pyridoxal phosphate%3B Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate%2C the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family gene gene1642 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01643 S101447_01644 S101447_01644 S101447_01644 1679113 1679943 - Adenosylcobinamide-GDP ribazoletransferase Cell inner membrane%3B Cell membrane%3B Cobalamin biosynthesis%3B Magnesium%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate%3B Belongs to the CobS family%3B KEGG: apt:APA01_22440 adenosylcobinamide-GDP ribazoletransferase gene gene1643 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01644 S101447_01645 S101447_01645 cobU cobU 1679940 1680989 - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Cobalamin biosynthesis%3B Glycosyltransferase%3B Transferase%3B Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5%2C6- dimethylbenzimidazole (DMB)%3B Belongs to the CobT family%3B KEGG: apt:APA01_22430 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase gene gene1644 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01645 S101447_01646 S101447_01646 cobP cobP 1681051 1681605 + Adenosylcobinamide kinase ATP-binding%3B Cobalamin biosynthesis%3B GTP-binding%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. Belongs to the CobU/CobP family%3B KEGG: apt:APA01_22420 adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase gene gene1645 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01646 S101447_01647 S101447_01647 S101447_01647 1681620 1682816 - putative sugar efflux transporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites%3B Belongs to the major facilitator superfamily. SotB (TC 2. A. 1. 2) family gene gene1646 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01647 S101447_01648 S101447_01648 S101447_01648 1683016 1684470 + Succinate-semialdehyde dehydrogenase (NAD(P)(+)) Metal-binding%3B NAD%3B NADP%3B Oxidation%3B Oxidoreductase%3B Potassium%3B Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid%3B Belongs to the aldehyde dehydrogenase family%3B KEGG: apt:APA01_22400 succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase gene gene1647 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01648 S101447_01649 S101447_01649 S101447_01649 1684575 1685894 - D-sorbitol dehydrogenase (acceptor) Cell membrane%3B Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Pyrrolidone carboxylic acid%3B Repeat%3B Signal%3B Transport%3B Dehydration of primary alcohols (exception: methanol). Contains 3 cytochrome c domains%3B KEGG: bpm:BURPS1710b_A2590 D-sorbitol dehydrogenase (acceptor)%3B overlaps another CDS with the same product name gene gene1648 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01649 S101447_01650 S101447_01650 S101447_01650 1685887 1687524 - D-sorbitol dehydrogenase (acceptor) Cell membrane%3B FAD%3B Flavoprotein%3B Membrane%3B Oxidoreductase%3B Catalytic subunit of fructose dehydrogenase%2C an enzyme that catalyzes the oxidation of D-fructose to produce 5-keto-D- fructose%3B Belongs to the GMC oxidoreductase family%3B KEGG: gox:GOX2096 D-sorbitol dehydrogenase (acceptor)%3B overlaps another CDS with the same product name gene gene1649 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01650 S101447_01651 S101447_01651 S101447_01651 1687546 1688169 - D-sorbitol dehydrogenase (acceptor) KEGG: gox:GOX2097 D-sorbitol dehydrogenase (acceptor) gene gene1650 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01651 S101447_01652 S101447_01652 S101447_01652 1688333 1688797 - hypothetical protein gene gene1651 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01652 S101447_01653 S101447_01653 S101447_01653 1688843 1689085 + hypothetical protein gene gene1652 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01653 S101447_01654 S101447_01654 S101447_01654 1689155 1690747 - hypothetical protein gene gene1653 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01654 S101447_01655 S101447_01655 S101447_01655 1691116 1692462 - C4-dicarboxylate transport protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Sugar transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Responsible for the transport of dicarboxylates such as succinate%2C fumarate%2C and malate from the periplasm across the membrane%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene1654 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01655 S101447_01656 S101447_01656 vanA vanA 1692820 1693875 - Vanillate monooxygenase 2Fe-2S%3B Chlorophyll biosynthesis%3B Chloroplast%3B Coiled coil%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B NADP%3B Oxidoreductase%3B Plastid%3B Plastid inner membrane%3B Thylakoid%3B Transit peptide%3B Catalyzes a two-step oxygenase reaction involved in the synthesis of chlorophyll b. Acts specifically on the non- esterified chlorophyllide a and not on chlorophyll a. Contains 1 Rieske domain%3B KEGG: apt:APA01_22330 vanillate O-demethylase monooxygenase subunit gene gene1655 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01656 S101447_01657 S101447_01657 S101447_01657 1693996 1694910 + HTH-type transcriptional regulator BudR DNA-binding%3B Transcription%3B Transcription regulation%3B Regulator of the budABC operon for 2%2C3-butanediol synthesis%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1656 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01657 S101447_01658 S101447_01658 S101447_01658 1694974 1695834 - Nascent polypeptide-associated complex subunit alpha%2C muscle-specific form Acetylation%3B Activator%3B Alternative splicing%3B Cytoplasm%3B DNA-binding%3B Nucleus%3B Phosphoprotein%3B Polymorphism%3B Repeat%3B Transcription%3B Transcription regulation%3B Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity)%3B Contains 1 NAC-A/B (NAC-alpha/beta) domain%3B Contains 1 UBA domain gene gene1657 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01658 S101447_01659 S101447_01659 S101447_01659 1695831 1696280 - Protein TolR Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-independent uptake of proteins%3B Belongs to the ExbD/TolR family gene gene1658 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01659 S101447_01660 S101447_01660 S101447_01660 1696286 1697038 - Biopolymer transport protein Bacteriocin transport%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity)%3B Belongs to the ExbB/TolQ family gene gene1659 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01660 S101447_01661 S101447_01661 S101447_01661 1697516 1699825 + Catecholate siderophore receptor Fiu Cell outer membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Involved in the active transport across the outer membrane of iron complexed with catecholate siderophores such as dihydroxybenzoylserine and dihydroxybenzoate. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. Can also transport catechol-substituted cephalosporins. Receptor for microcins M%2C H47 and E492 (By similarity)%3B Belongs to the TonB-dependent receptor family gene gene1660 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01661 S101447_01662 S101447_01662 S101447_01662 1699885 1700607 + uncharacterized protein To E. coli YbeT gene gene1661 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01662 S101447_01663 S101447_01663 S101447_01663 1700659 1701189 + hypothetical protein gene gene1662 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01663 S101447_01664 S101447_01664 S101447_01664 1701205 1701888 + PKHD-type hydroxylase Dioxygenase%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Vitamin C%3B Contains 1 Fe2OG dioxygenase domain%3B KEGG: xsa:SB85_19330 PKHD-type hydroxylase%3B With 2-oxoglutarate as one donor%2C and incorporation of one atom each of oxygen into both donors gene gene1663 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01664 S101447_01665 S101447_01665 S101447_01665 1702080 1703090 - HTH-type transcriptional regulator VirS DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Virulence%3B Regulates the expression of the mymA operon%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene1664 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01665 S101447_01666 S101447_01666 aoc3 aoc3 1703309 1705261 + Primary-amine oxidase Copper%3B Metal-binding%3B Oxidoreductase%3B TPQ%3B The exact function of MaoXI is not known. Belongs to the copper/topaquinone oxidase family%3B KEGG: apk:APA386B_241 primary-amine oxidase gene gene1665 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01666 S101447_01667 S101447_01667 S101447_01667 1705327 1705581 + hypothetical protein gene gene1666 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01667 S101447_01668 S101447_01668 S101447_01668 1705627 1706928 + Ammonia channel Ammonia transport%3B Cell membrane%3B Membrane%3B Signal%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the uptake of ammonia. Belongs to the ammonia transporter channel (TC 1. A. 11. 2) family gene gene1667 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01668 S101447_01669 S101447_01669 S101447_01669 1707393 1710173 + AIDA-I autotransporter Autocatalytic cleavage%3B Cell adhesion%3B Cell outer membrane%3B Glycoprotein%3B Membrane%3B Periplasm%3B Plasmid%3B Secreted%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Virulence%3B Potent bacterial adhesin that mediates bacterial attachment to a broad variety of human and other mammalian cells. AIDA possesses additional virulence properties%2C as it is capable of mediating bacterial autoaggregation via intercellular self- recognition and it is a highly efficient initiator of biofilm formation%3B Contains 1 autotransporter (TC 1. B. 12) domain gene gene1668 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01669 S101447_01670 S101447_01670 acsL acsL 1710261 1711727 + Long-chain-fatty-acid--CoA ligase KEGG: sri:SELR_09730 long-chain acyl-CoA synthetase gene gene1669 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01670 S101447_01671 S101447_01671 S101447_01671 1711764 1718063 + Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsB Fatty acid metabolism%3B Lipid metabolism%3B Multifunctional enzyme%3B NADP%3B Oxidoreductase%3B Phosphopantetheine%3B Phosphoprotein%3B Repeat%3B Transferase%3B Involved in the elongation of either C22-24 fatty acids or p-hydroxyphenylalkanoic acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol and phenolphthiocerol derivatives%2C respectively%3B Contains 1 acyl carrier domain gene gene1670 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01671 S101447_01672 S101447_01672 S101447_01672 1718066 1719856 + Long-chain-fatty-acid--AMP ligase FadD32 ATP-binding%3B Fatty acid metabolism%3B Ligase%3B Lipid metabolism%3B Nucleotide-binding%3B Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP)%2C which are then transferred to the multifunctional polyketide synthase (PKS) for further chain extension%3B Belongs to the ATP-dependent AMP-binding enzyme family gene gene1671 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01672 S101447_01673 S101447_01673 S101447_01673 1719856 1721016 + Glycosyltransferase TibC Glycosyltransferase%3B Transferase%3B Glycosylates the TibA adhesin%3B KEGG: gox:GOX0999 null%3B Hexosyltransferases gene gene1672 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01673 S101447_01674 S101447_01674 S101447_01674 1721265 1723508 - Ferrichrome-iron receptor Cell outer membrane%3B Disulfide bond%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B This receptor binds the ferrichrome-iron ligand. It interacts with the TonB protein%2C which is responsible for energy coupling of the ferrichrome-promoted iron transport system. Acts as a receptor for bacteriophage T5 as well as T1%2C phi80 and colicin M. Binding of T5 triggers the opening of a high conductance ion channel. Can also transport the antibiotic albomycin%3B Belongs to the TonB-dependent receptor family gene gene1673 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01674 S101447_01675 S101447_01675 S101447_01675 1723545 1724267 - hypothetical protein gene gene1674 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01675 S101447_01676 S101447_01676 S101447_01676 1724525 1726078 + Diaminobutyrate decarboxylase Decarboxylase%3B Lyase%3B Plasmid%3B Pyridoxal phosphate%3B Belongs to the group II decarboxylase family%3B KEGG: stre:GZL_06725 L-2%2C4-diaminobutyrate decarboxylase gene gene1675 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01676 S101447_01677 S101447_01677 iucD iucD 1726075 1727406 + L-lysine N(6)-monooxygenase (NADPH) FAD%3B Flavoprotein%3B NADP%3B Oxidoreductase%3B Plasmid%3B Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family%3B KEGG: son:SO_3030 lysine N6-hydroxylase gene gene1676 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01677 S101447_01678 S101447_01678 iucB iucB 1727469 1729853 + N(6)-hydroxylysine O-acetyltransferase Plasmid%3B Belongs to the IucB family%3B KEGG: spoi:IMCC21906_00380 acetyl CoA:N6-hydroxylysine acetyl transferase gene gene1677 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01678 S101447_01679 S101447_01679 S101447_01679 1729964 1731256 + putative multidrug resistance protein YoeA Antiport%3B Cell membrane%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene1678 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01679 S101447_01680 S101447_01680 S101447_01680 1731408 1734572 + Multidrug resistance protein MdtC Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MdtC subfamily gene gene1679 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01680 S101447_01681 S101447_01681 S101447_01681 1734565 1735737 + Multidrug resistance protein MdtE Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Transport%3B Part of the tripartite efflux system MdtEF-TolC%2C which confers resistance to various compounds%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene1680 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01681 S101447_01682 S101447_01682 S101447_01682 1735727 1737145 + putative efflux pump outer membrane protein SepC Cell outer membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Probable outer membrane component of the SepABC efflux pump with unknown specificity. Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene1681 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01682 S101447_01683 S101447_01683 guaB guaB 1737331 1737831 - IMP dehydrogenase CBS domain%3B Disulfide bond%3B Metal-binding%3B Repeat%3B Secreted%3B Zinc%3B Unlike some other CBS-domain containing proteins does not seem to bind AMP%3B Contains 2 CBS domains%3B KEGG: bma:BMAA1350 IMP dehydrogenase gene gene1682 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01683 S101447_01684 S101447_01684 nuoN nuoN 1737877 1739337 - NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 2 family%3B KEGG: gxl:H845_1102 NADH-quinone oxidoreductase subunit N%3B overlaps another CDS with the same product name gene gene1683 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01684 S101447_01685 S101447_01685 S101447_01685 1739334 1740851 - NADH:ubiquinone reductase (H(+)-translocating) Cell membrane%3B Electron transport%3B Membrane%3B Methanogenesis%3B Methanol utilization%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2)%2C via FAD and iron-sulfur (Fe-S) centers%2C to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred%2C two hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient. It also catalyzes the oxidation of F(420)H(2) with quinones such as 2%2C3- dimethyl-1%2C4-naphthoquinone%2C 2-methyl-1%2C4-naphthoquinone and tetramethyl-p-benzoquinone%3B Belongs to the complex I subunit 4 family%3B KEGG: gxl:H845_1104 NADH-quinone oxidoreductase subunit M%3B overlaps another CDS with the same product name gene gene1684 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01685 S101447_01686 S101447_01686 nuoL nuoL 1740848 1742815 - NADH:ubiquinone reductase (H(+)-translocating) Chloroplast%3B Membrane%3B NAD%3B NADP%3B Oxidoreductase%3B Plastid%3B Plastoquinone%3B Quinone%3B Thylakoid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B NDH shuttles electrons from NAD(P)H:plastoquinone%2C via FMN and iron-sulfur (Fe-S) centers%2C to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation%2C and thus conserves the redox energy in a proton gradient (By similarity)%3B Belongs to the complex I subunit 5 family%3B KEGG: goh:B932_1864 NADH-quinone oxidoreductase subunit L%3B overlaps another CDS with the same product name gene gene1685 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01686 S101447_01687 S101447_01687 nuoK nuoK 1742820 1743131 - NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Transport%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 4L family%3B KEGG: gxl:H845_1106 NADH-quinone oxidoreductase subunit K gene gene1686 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01687 S101447_01688 S101447_01688 nuoJ nuoJ 1743133 1743633 - NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient (By similarity)%3B Belongs to the complex I subunit 6 family%3B KEGG: gxl:H845_1107 NADH-quinone oxidoreductase subunit J gene gene1687 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01688 S101447_01689 S101447_01689 nuoI nuoI 1743639 1744151 - NADH:ubiquinone reductase (H(+)-translocating) 4Fe-4S%3B Cell inner membrane%3B Cell membrane%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Quinone%3B Repeat%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I 23 kDa subunit family%3B Contains 2 4Fe-4S ferredoxin-type domains%3B KEGG: nmu:Nmul_A1020 NADH-quinone oxidoreductase subunit I gene gene1688 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01689 S101447_01690 S101447_01690 nuoH nuoH 1744177 1745133 - NADH:ubiquinone reductase (H(+)-translocating) Electron transport%3B Membrane%3B Mitochondrion%3B Mitochondrion inner membrane%3B NAD%3B Oxidoreductase%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone%3B Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)%3B Belongs to the complex I subunit 1 family%3B KEGG: gxl:H845_1110 NADH-quinone oxidoreductase subunit H%3B overlaps another CDS with the same product name gene gene1689 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01690 S101447_01691 S101447_01691 nuoG nuoG 1745130 1747865 - NADH:ubiquinone reductase (H(+)-translocating) 2Fe-2S%3B 4Fe-4S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Quinone%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient (By similarity)%3B Belongs to the complex I 75 kDa subunit family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 4Fe-4S Mo/W bis-MGD-type domain%3B KEGG: gxl:H845_1111 NADH-quinone oxidoreductase subunit G%3B overlaps another CDS with the same product name gene gene1690 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01691 S101447_01692 S101447_01692 nuoF nuoF 1747862 1749169 - NADH:ubiquinone reductase (H(+)-translocating) 4Fe-4S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B NADP%3B Oxidoreductase%3B Repeat%3B Catalyzes the reduction of NADP in the presence of molecular H2 to yield NADPH%3B Belongs to the complex I 51 kDa subunit family%3B Contains 2 4Fe-4S ferredoxin-type domains%3B KEGG: gxl:H845_1112 NADH-quinone oxidoreductase subunit F%3B overlaps another CDS with the same product name gene gene1691 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01692 S101447_01693 S101447_01693 nuoE nuoE 1749166 1749657 - NADH:ubiquinone reductase (H(+)-translocating) 2Fe-2S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Quinone%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient (By similarity)%3B Belongs to the complex I 24 kDa subunit family%3B KEGG: swd:Swoo_2863 NADH-quinone oxidoreductase subunit E%3B overlaps another CDS with the same product name gene gene1692 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01693 S101447_01694 S101447_01694 S101447_01694 1749644 1750600 - NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B Multifunctional enzyme%3B NAD%3B Oxidoreductase%3B Quinone%3B Transport%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B In the N-terminal sectio%3B belongs to the complex I 30 kDa subunit family%3B In the C-terminal sectio%3B belongs to the complex I 49 kDa subunit family%3B KEGG: swd:Swoo_2862 NADH-quinone oxidoreductase subunit C/D%3B overlaps another CDS with the same product name gene gene1693 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01694 S101447_01695 S101447_01695 S101447_01695 1751017 1751352 - hypothetical protein gene gene1694 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01695 S101447_01696 S101447_01696 S101447_01696 1751429 1752259 - NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B Multifunctional enzyme%3B NAD%3B Oxidoreductase%3B Quinone%3B Transport%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B In the N-terminal sectio%3B belongs to the complex I 30 kDa subunit family%3B In the C-terminal sectio%3B belongs to the complex I 49 kDa subunit family%3B KEGG: gxl:H845_1114 NADH-quinone oxidoreductase subunit C/D gene gene1695 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01696 S101447_01697 S101447_01697 nuoB nuoB 1752265 1752900 - NADH:ubiquinone reductase (H(+)-translocating) 4Fe-4S%3B Cell inner membrane%3B Cell membrane%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Quinone%3B Transport%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I 20 kDa subunit family%3B KEGG: gxl:H845_1115 NADH-quinone oxidoreductase subunit B%3B overlaps another CDS with the same product name gene gene1696 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01697 S101447_01698 S101447_01698 nuoA nuoA 1752897 1753205 - NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 3 family%3B KEGG: gxl:H845_1116 NADH-quinone oxidoreductase subunit A%3B overlaps another CDS with the same product name gene gene1697 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01698 S101447_01699 S101447_01699 S101447_01699 1754008 1754083 - tRNA-Glu tRNA gene1698 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01699 S101447_01700 S101447_01700 cysG cysG 1754458 1755861 + Uroporphyrinogen-III C-methyltransferase Cobalamin biosynthesis%3B Lyase%3B Methyltransferase%3B Multifunctional enzyme%3B NAD%3B Oxidoreductase%3B Phosphoprotein%3B Porphyrin biosynthesis%3B S-adenosyl-L-methionine%3B Transferase%3B Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally%2C it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme%3B In the N-terminal sectio%3B belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family%3B In the C-terminal sectio%3B belongs to the precorrin methyltransferase family%3B KEGG: apt:APA01_21940 uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase gene gene1699 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01700 S101447_01701 S101447_01701 ldhD ldhD 1755951 1757378 + D-lactate dehydrogenase (cytochrome) FAD%3B Flavoprotein%3B Mitochondrion%3B Oxidoreductase%3B Transit peptide%3B Zinc%3B Catalyzes the stereospecific oxidation of D-lactate to pyruvate. Belongs to the FAD-binding oxidoreductase/transferase type 4 family%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: apt:APA01_21930 D-lactate dehydrogenase (cytochrome) gene gene1700 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01701 S101447_01702 S101447_01702 S101447_01702 1757477 1758289 + putative D-methionine-binding lipoprotein MetQ Amino-acid transport%3B Cell membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Transport%3B This protein is a component of a D-methionine permease%2C a binding protein-dependent%2C ATP-driven transport system%3B Belongs to the NlpA lipoprotein family gene gene1701 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01702 S101447_01703 S101447_01703 S101447_01703 1758286 1759269 + Fe(3+) ions import ATP-binding protein FbpC ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3. A. 1. 10) family%3B Contains 1 ABC transporter domain gene gene1702 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01703 S101447_01704 S101447_01704 S101447_01704 1759250 1759924 + putative D-methionine transport system permease protein MetI Amino-acid transport%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the binding-protein-dependent transport system for D-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1703 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01704 S101447_01705 S101447_01705 yhb1 yhb1 1759978 1761192 - Nitric oxide dioxygenase Detoxification%3B FAD%3B Flavoprotein%3B Heme%3B Iron%3B Metal-binding%3B NAD%3B NADP%3B Oxidoreductase%3B Oxygen transport%3B Transport%3B Is involved in NO detoxification in an aerobic process%2C termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate%2C which protects the bacterium from various noxious nitrogen compounds. Therefore%2C plays a central role in the inducible response to nitrosative stress%3B Belongs to the globin family. Two-domain flavohemoproteins subfamily%3B In the C-terminal sectio%3B belongs to the flavoprotein pyridine nucleotide cytochrome reductase family%3B Contains 1 FAD-binding FR-type domain%3B KEGG: apt:APA01_21890 nitric oxide dioxygenase gene gene1704 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01705 S101447_01706 S101447_01706 S101447_01706 1761563 1761931 + hypothetical protein gene gene1705 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01706 S101447_01707 S101447_01707 cwlA cwlA 1762034 1763194 - N-acetylmuramoyl-L-alanine amidase Signal%3B Belongs to the UPF0214 family%3B KEGG: pat:Patl_4160 N-acetylmuramoyl-L-alanine amidase gene gene1706 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01707 S101447_01708 S101447_01708 alkB alkB 1763240 1763908 - DNA oxidative demethylase Dioxygenase%3B DNA damage%3B DNA repair%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine%2C and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen%2C alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents)%2C but not to MMNG and MNU (SN1 agents)%3B Belongs to the alkB family%3B Contains 1 Fe2OG dioxygenase domain%3B KEGG: apt:APA01_21860 alkylated DNA repair protein (DNA oxidative demethylase) gene gene1707 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01708 S101447_01709 S101447_01709 S101447_01709 1764018 1764404 + hypothetical protein gene gene1708 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01709 S101447_01710 S101447_01710 S101447_01710 1764476 1766023 - putative symporter YodF Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the sodium:solute symporter (SSF) (TC 2. A. 21) family gene gene1709 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01710 S101447_01711 S101447_01711 S101447_01711 1766282 1766773 - hypothetical protein gene gene1710 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01711 S101447_01712 S101447_01712 anmK anmK 1766806 1767951 - Anhydro-N-acetylmuramic acid kinase ATP-binding%3B Carbohydrate metabolism%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Catalyzes the specific phosphorylation of 1%2C6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1%2C6-anhydro ring%2C generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein%2C and thus plays a role in cell wall recycling%3B Belongs to the anhydro-N-acetylmuramic acid kinase family%3B KEGG: apk:APA386B_1039 anhydro-N-acetylmuramic acid kinase gene gene1711 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01712 S101447_01713 S101447_01713 S101447_01713 1767956 1768312 - hypothetical protein gene gene1712 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01713 S101447_01714 S101447_01714 pdxJ pdxJ 1768314 1769036 - Pyridoxine 5'-phosphate synthase Cytoplasm%3B Pyridoxine biosynthesis%3B Transferase%3B Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate%3B Belongs to the PNP synthase family%3B KEGG: apt:APA01_21790 pyridoxine 5-phosphate synthase gene gene1713 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01714 S101447_01715 S101447_01715 pdxA pdxA 1769033 1770004 - 4-hydroxythreonine-4-phosphate dehydrogenase Cobalt%3B Cytoplasm%3B Magnesium%3B Metal-binding%3B NAD%3B NADP%3B Oxidoreductase%3B Pyridoxine biosynthesis%3B Zinc%3B Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)%3B Belongs to the PdxA family%3B KEGG: apt:APA01_21780 4-hydroxythreonine-4-phosphate dehydrogenase gene gene1714 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01715 S101447_01716 S101447_01716 S101447_01716 1770052 1770714 - hypothetical protein gene gene1715 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01716 S101447_01717 S101447_01717 S101447_01717 1770769 1771263 - Protein-export protein SecB Chaperone%3B Cytoplasm%3B Protein transport%3B Translocation%3B Transport%3B One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins%2C maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA%3B Belongs to the SecB family gene gene1716 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01717 S101447_01718 S101447_01718 S101447_01718 1771597 1771866 + hypothetical protein gene gene1717 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01718 S101447_01719 S101447_01719 pyrF pyrF 1771859 1772572 + Orotidine-5'-phosphate decarboxylase Decarboxylase%3B Lyase%3B Pyrimidine biosynthesis%3B Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)%3B Belongs to the OMP decarboxylase family. Type 1 subfamily%3B KEGG: apt:APA01_21740 orotidine-5'-phosphate decarboxylase gene gene1718 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01719 S101447_01720 S101447_01720 trpF trpF 1772588 1773241 + Phosphoribosylanthranilate isomerase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Isomerase%3B Tryptophan biosynthesis%3B Belongs to the TrpF family%3B KEGG: adn:Alide_3146 phosphoribosylanthranilate isomerase gene gene1719 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01720 S101447_01721 S101447_01721 S101447_01721 1773313 1773403 + tRNA-Ser tRNA gene1720 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01721 S101447_01722 S101447_01722 alaA alaA 1773559 1774767 + Valine--pyruvate transaminase DNA integration%3B DNA recombination%3B Viral genome integration%3B Virus entry into host cell%3B Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase%2C integrase is also necessary for excision of the prophage from the host genome. Belongs to the 'phage' integrase family%3B KEGG: lhk:LHK_02491 alanine-synthesizing transaminase gene gene1721 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01722 S101447_01723 S101447_01723 S101447_01723 1774877 1775065 - hypothetical protein gene gene1722 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01723 S101447_01724 S101447_01724 S101447_01724 1775803 1776528 - hypothetical protein gene gene1723 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01724 S101447_01725 S101447_01725 S101447_01725 1776525 1777304 - hypothetical protein gene gene1724 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01725 S101447_01726 S101447_01726 S101447_01726 1777488 1778027 - hypothetical protein gene gene1725 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01726 S101447_01727 S101447_01727 S101447_01727 1778053 1778421 - hypothetical protein gene gene1726 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01727 S101447_01728 S101447_01728 S101447_01728 1778541 1779347 + hypothetical protein gene gene1727 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01728 S101447_01729 S101447_01729 S101447_01729 1779344 1779442 + hypothetical protein gene gene1728 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01729 S101447_01730 S101447_01730 S101447_01730 1779442 1779582 + hypothetical protein gene gene1729 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01730 S101447_01731 S101447_01731 S101447_01731 1779614 1779985 + uncharacterized protein Plasmid%3B Transposable element%3B Transposition%3B To transposase of insertion sequence IS6501 gene gene1730 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01731 S101447_01732 S101447_01732 S101447_01732 1780298 1780765 - Non-specific serine/threonine protein kinase KEGG: cch:Cag_1363 serine/threonine protein kinase%2C bacterial gene gene1731 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01732 S101447_01733 S101447_01733 S101447_01733 1780861 1781214 - Non-specific serine/threonine protein kinase KEGG: cch:Cag_1363 serine/threonine protein kinase%2C bacterial gene gene1732 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01733 S101447_01734 S101447_01734 S101447_01734 1781954 1782424 + hypothetical protein gene gene1733 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01734 S101447_01735 S101447_01735 S101447_01735 1782443 1783678 + hypothetical protein gene gene1734 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01735 S101447_01736 S101447_01736 S101447_01736 1783627 1784829 + hypothetical protein gene gene1735 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01736 S101447_01737 S101447_01737 S101447_01737 1784829 1787903 + Cation efflux system protein CusA Cell inner membrane%3B Cell membrane%3B Copper%3B Copper transport%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of a cation efflux system that mediates resistance to copper and silver%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene1736 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01737 S101447_01738 S101447_01738 S101447_01738 1787903 1788574 + Transcriptional regulatory protein Activator%3B Antibiotic resistance%3B Cytoplasm%3B DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system%3B Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd%2C ais%2C arnBCADTEF and eptA-basRS loci%2C all involved in resistance to polymyxin (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1737 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01738 S101447_01739 S101447_01739 S101447_01739 1788571 1789923 + Histidine kinase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system%3B Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation%3B Contains 1 histidine kinase domain%3B KEGG: apt:APA01_15910 two-component system%2C OmpR family%2C sensor kinase gene gene1738 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01739 S101447_01740 S101447_01740 S101447_01740 1789948 1790067 + hypothetical protein gene gene1739 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01740 S101447_01741 S101447_01741 S101447_01741 1790057 1790761 + Fe(2+)/Mn(2+) transporter pcl1 Endoplasmic reticulum%3B Golgi apparatus%3B Membrane%3B Phosphoprotein%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Vacuole%3B Has a role in both calcium and manganese homeostasis. Involved in the transfer of iron and Mn(2+) from the cytosol to the vacuole for storage of these metals (By similarity)%3B Belongs to the CCC1 family gene gene1740 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01741 S101447_01742 S101447_01742 S101447_01742 1791108 1791974 - Transposase for insertion sequence element IS3411 DNA recombination%3B DNA-binding%3B Transposable element%3B Transposition%3B Involved in the transposition of the insertion sequence. Contains 1 integrase catalytic domain gene gene1741 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01742 S101447_01743 S101447_01743 S101447_01743 1792005 1792328 - Insertion element IS629 uncharacterized 12 kDa protein Transposable element%3B Belongs to the transposase 8 family gene gene1742 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01743 S101447_01744 S101447_01744 S101447_01744 1792853 1793503 + HTH-type transcriptional regulator RutR DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX) (By similarity)%3B Contains 1 HTH tetR-type DNA-binding domain gene gene1743 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01744 S101447_01745 S101447_01745 S101447_01745 1793454 1794911 - Purine-uracil permease NCS1 Chloroplast%3B Membrane%3B Plastid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Nucleobase-proton symporter that facilitates the uptake of nucleobases in the cells. Can transport adenine%2C guanine and uracil (PubMed:22616996%2C PubMed:22474184%2C PubMed:24621654). Contributes to uracil import into plastids for plastidic uracil salvage which is essential for plant growth and development (PubMed:22474184)%3B Belongs to the purine-cytosine permease (2. A. 39) family gene gene1744 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01745 S101447_01746 S101447_01746 dpyS dpyS 1795040 1796440 + Dihydropyrimidinase Hydrolase%3B Metal-binding%3B Zinc%3B Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins%2C to produce N-carbamoyl-D-amino acids%3B Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily%3B KEGG: gxy:GLX_03800 dihydropyrimidinase gene gene1745 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01746 S101447_01747 S101447_01747 S101447_01747 1796437 1797447 - hypothetical protein gene gene1746 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01747 S101447_01748 S101447_01748 S101447_01748 1797668 1800085 + hypothetical protein gene gene1747 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01748 S101447_01749 S101447_01749 gltD gltD 1800198 1801541 + Glutamate synthase (NADPH) NAD%3B Oxidoreductase%3B Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5%2C6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5%2C6- dihydrothymine (DHT) (By similarity)%3B Belongs to the NADH dehydrogenase family%3B KEGG: apt:APA01_21620 glutamate synthase (NADPH/NADH) small chain gene gene1748 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01749 S101447_01750 S101447_01750 preA preA 1801557 1802825 + Dihydrouracil dehydrogenase (NAD(+)) 4Fe-4S%3B FAD%3B Flavoprotein%3B FMN%3B Iron%3B Iron-sulfur%3B Metal-binding%3B NADP%3B Nucleotide-binding%3B Oxidoreductase%3B Repeat%3B Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (By similarity)%3B Belongs to the dihydropyrimidine dehydrogenase family%3B Contains 3 4Fe-4S ferredoxin-type domains%3B KEGG: bbt:BBta_6035 dihydropyrimidine dehydrogenase (NAD+) subunit PreA gene gene1749 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01750 S101447_01751 S101447_01751 S101447_01751 1802861 1804123 + N-carbamoyl-L-amino-acid hydrolase Amino-acid biosynthesis%3B Hydrolase%3B Plasmid%3B Converts N-carbamyl-L-amino acids to L-amino acids. Belongs to the peptidase M20 family%3B KEGG: apt:APA01_21600 N-carbamoyl-L-amino-acid hydrolase gene gene1750 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01751 S101447_01752 S101447_01752 S101447_01752 1804177 1805592 - putative HTH-type transcriptional regulator YdcR Aminotransferase%3B DNA-binding%3B Pyridoxal phosphate%3B Transcription%3B Transcription regulation%3B Transferase%3B In the C-terminal sectio%3B belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B Contains 1 HTH gntR-type DNA-binding domain gene gene1751 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01752 S101447_01753 S101447_01753 S101447_01753 1805727 1807076 + Beta-alanine--pyruvate transaminase Aminotransferase%3B Biotin biosynthesis%3B Cytoplasm%3B Pyridoxal phosphate%3B S-adenosyl-L-methionine%3B Transferase%3B Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7%2C8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily%3B KEGG: apt:APA01_21580 beta-alanine--pyruvate transaminase gene gene1752 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01753 S101447_01754 S101447_01754 praC praC 1807117 1807506 + 2-hydroxymuconate tautomerase Isomerase%3B Putative target of GltR. Belongs to the 4-oxalocrotonate tautomerase family%3B KEGG: mav:MAV_2790 4-oxalocrotonate tautomerase gene gene1753 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01754 S101447_01755 S101447_01755 S101447_01755 1807858 1810545 + AIDA-I autotransporter Autocatalytic cleavage%3B Cell adhesion%3B Cell outer membrane%3B Glycoprotein%3B Membrane%3B Periplasm%3B Plasmid%3B Secreted%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Virulence%3B Potent bacterial adhesin that mediates bacterial attachment to a broad variety of human and other mammalian cells. AIDA possesses additional virulence properties%2C as it is capable of mediating bacterial autoaggregation via intercellular self- recognition and it is a highly efficient initiator of biofilm formation%3B Contains 1 autotransporter (TC 1. B. 12) domain gene gene1754 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01755 S101447_01756 S101447_01756 quiA quiA 1811268 1813706 + Quinate dehydrogenase (quinone) Cell membrane%3B Membrane%3B Oxidoreductase%3B PQQ%3B Quinate metabolism%3B Transmembrane%3B Transmembrane helix%3B Can act either on quinate or on shikimate. Belongs to the bacterial PQQ dehydrogenase family%3B KEGG: apt:APA01_21550 quinate dehydrogenase (quinone) gene gene1755 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01756 S101447_01757 S101447_01757 S101447_01757 1813808 1814800 - hypothetical protein gene gene1756 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01757 S101447_01758 S101447_01758 S101447_01758 1814800 1816398 - L-asparagine permease Amino-acid transport%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2. A. 3. 1) family gene gene1757 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01758 S101447_01759 S101447_01759 S101447_01759 1816723 1817517 - Linocin-M18 Antibiotic%3B Antimicrobial%3B Bacteriocin%3B Hydrolase%3B Protease%3B Secreted%3B Bacteriocin that has antimicrobial activity against a wide range of Gram-positive bacteria%2C including L. monocytogenes%2C B. cereus and S. aureus. May have a protease activity. Belongs to the peptidase U56 family gene gene1758 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01759 S101447_01760 S101447_01760 S101447_01760 1817519 1818658 - putative deferrochelatase/peroxidase YfeX Cytoplasm%3B Heme%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Peroxidase%3B Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact%3B Belongs to the DyP-type peroxidase family gene gene1759 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01760 S101447_01761 S101447_01761 cydA cydA 1818885 1820318 + Cytochrome bd ubiquinol oxidase subunit Cell membrane%3B Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the cytochrome ubiquinol oxidase subunit 1 family%3B KEGG: apt:APA01_21500 cytochrome d ubiquinol oxidase subunit I%3B With oxygen as acceptor gene gene1760 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01761 S101447_01762 S101447_01762 cydB cydB 1820324 1821340 + Cytochrome bd-II ubiquinol oxidase subunit Cell inner membrane%3B Cell membrane%3B Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B Transport%3B A terminal oxidase that catalyzes quinol-dependent%2C Na(+)-independent oxygen uptake. Prefers menadiol over other quinols although ubiquinol was not tested (PubMed:8626304). Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O%2C transferring 1 proton/electron%3B Belongs to the cytochrome ubiquinol oxidase subunit 2 family%3B KEGG: xac:XAC3736 cytochrome d ubiquinol oxidase subunit II%3B With oxygen as acceptor gene gene1761 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01762 S101447_01763 S101447_01763 S101447_01763 1821327 1821476 + hypothetical protein gene gene1762 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01763 S101447_01764 S101447_01764 S101447_01764 1821537 1821869 - hypothetical protein gene gene1763 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01764 S101447_01765 S101447_01765 S101447_01765 1822224 1823684 + Osmoprotectant uptake system Cell inner membrane%3B Cell membrane%3B Membrane%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in uptake and accumulation of various osmoprotectants. Allows the uptake of glycine betaine%2C proline%2C ectoine%2C and pipecolic acid. Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family gene gene1764 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01765 S101447_01766 S101447_01766 S101447_01766 1823765 1824511 - hypothetical protein gene gene1765 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01766 S101447_01767 S101447_01767 S101447_01767 1824607 1825227 - hypothetical protein gene gene1766 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01767 S101447_01768 S101447_01768 dpo1 dpo1 1825232 1828033 - DNA-directed DNA polymerase DNA damage%3B DNA repair%3B DNA replication%3B DNA-binding%3B DNA-directed DNA polymerase%3B Exonuclease%3B Hydrolase%3B Nuclease%3B Nucleotidyltransferase%3B Transferase%3B In addition to polymerase activity%2C this DNA polymerase 5' to 3' exonuclease activity%3B Belongs to the DNA polymerase type-A family%3B Contains 1 5'-3' exonuclease domain%3B KEGG: csa:Csal_0548 DNA polymerase I gene gene1767 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01768 S101447_01769 S101447_01769 ilvE ilvE 1828221 1829321 - Branched-chain-amino-acid transaminase Amino-acid biosynthesis%3B Aminotransferase%3B Branched-chain amino acid biosynthesis%3B Pyridoxal phosphate%3B Transferase%3B Acts on leucine%2C isoleucine and valine%3B Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: apt:APA01_21420 branched-chain amino acid aminotransferase gene gene1768 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01769 S101447_01770 S101447_01770 S101447_01770 1829602 1831065 + UPF0061 protein Belongs to the UPF0061 (SELO) family gene gene1769 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01770 S101447_01771 S101447_01771 S101447_01771 1831086 1831898 - Iron-chelate-transporting ATPase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3. A. 1. 14. 5) family%3B Contains 1 ABC transporter domain%3B KEGG: apt:APA01_21400 iron complex transport system ATP-binding protein gene gene1770 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01771 S101447_01772 S101447_01772 S101447_01772 1831895 1833013 - Vitamin B12 import system permease protein BtuC Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily gene gene1771 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01772 S101447_01773 S101447_01773 rluD rluD 1833061 1834074 + 23S rRNA pseudouridine(1911/1915/1917) synthase Isomerase%3B RNA-binding%3B rRNA processing%3B Responsible for synthesis of pseudouridine from uracil at positions 1911%2C 1915 and 1917 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RluA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: apt:APA01_21380 23S rRNA pseudouridine1911/1915/1917 synthase gene gene1772 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01773 S101447_01774 S101447_01774 S101447_01774 1834393 1835283 + RNA polymerase sigma factor RpoH Cytoplasm%3B DNA-binding%3B Sigma factor%3B Stress response%3B Transcription%3B Transcription regulation%3B Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes%3B Belongs to the sigma-70 factor family. RpoH subfamily gene gene1773 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01774 S101447_01775 S101447_01775 recJ recJ 1835377 1837209 - Single-stranded-DNA-specific exonuclease RecJ Coiled coil%3B DNA-binding%3B Exonuclease%3B Hydrolase%3B Nuclease%3B Putative single-stranded-DNA-specific exonuclease (By similarity). RecA thread formation during DNA double-strand break repair requires RecJ or AadAB%3B Belongs to the RecJ family%3B Contains 1 OB DNA-binding domain%3B KEGG: apt:APA01_21360 single-stranded-DNA-specific exonuclease%3B Acting on ester bonds gene gene1774 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01775 S101447_01776 S101447_01776 S101447_01776 1837226 1838224 - Fructose-bisphosphatase Carbohydrate metabolism%3B Cytoplasm%3B Hydrolase%3B Magnesium%3B Manganese%3B Metal-binding%3B Catalyzes the hydrolysis of fructose 1%2C6-bisphosphate to fructose 6-phosphate. Is essential for growth on gluconeogenic carbon sources. Also displays a low activity toward glucose 6- phosphate%2C and fructose 6-phosphate%2C glycerol 3-phosphate%2C ribulose 1%2C5-bisphosphate and myo-inositol-monophosphate are not significant substrates%3B Belongs to the FBPase class 2 family%3B KEGG: apt:APA01_21350 fructose-1%2C6-bisphosphatase II / sedoheptulose-1%2C7-bisphosphatase gene gene1775 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01776 S101447_01777 S101447_01777 S101447_01777 1838278 1839591 - Homoserine dehydrogenase Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Isoleucine biosynthesis%3B Methionine biosynthesis%3B NADP%3B Oxidoreductase%3B Threonine biosynthesis%3B Belongs to the homoserine dehydrogenase family%3B Contains 1 ACT domain%3B KEGG: apt:APA01_21340 homoserine dehydrogenase gene gene1776 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01777 S101447_01778 S101447_01778 alaC alaC 1839588 1840820 - Putative aminotransferase AatC Aminotransferase%3B Cytoplasm%3B Pyridoxal phosphate%3B Transferase%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: mec:Q7C_1342 alanine-synthesizing transaminase%3B Transaminases gene gene1777 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01778 S101447_01779 S101447_01779 S101447_01779 1840958 1842043 - hypothetical protein gene gene1778 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01779 S101447_01780 S101447_01780 clpP clpP 1842177 1842857 + Endopeptidase Clp Cytoplasm%3B Hydrolase%3B Protease%3B Serine protease%3B Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins%3B Belongs to the peptidase S14 family%3B KEGG: apt:APA01_21310 ATP-dependent Clp protease%2C protease subunit gene gene1779 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01780 S101447_01781 S101447_01781 S101447_01781 1842996 1844009 + hypothetical protein gene gene1780 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01781 S101447_01782 S101447_01782 S101447_01782 1844079 1845173 - Coenzyme PQQ synthesis protein 4Fe-4S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B PQQ biosynthesis%3B S-adenosyl-L-methionine%3B Belongs to the radical SAM superfamily. PqqE family%3B overlaps another CDS with the same product name gene gene1781 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01782 S101447_01783 S101447_01783 S101447_01783 1845170 1845469 - Coenzyme PQQ synthesis protein Plasmid%3B PQQ biosynthesis%3B Belongs to the PqqD family%3B overlaps another CDS with the same product name gene gene1782 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01783 S101447_01784 S101447_01784 pqqC pqqC 1845466 1846206 - Pyrroloquinoline-quinone synthase Oxidoreductase%3B PQQ biosynthesis%3B Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4%2C5-dioxo-4%2C5%2C6%2C7%2C8%2C9-hexahydroquinoline- 7%2C9-dicarboxylic-acid to PQQ%3B Belongs to the PqqC family%3B KEGG: fau:Fraau_0285 pyrroloquinoline-quinone synthase gene gene1783 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01784 S101447_01785 S101447_01785 S101447_01785 1846203 1847114 - Coenzyme PQQ synthesis protein B PQQ biosynthesis%3B Transport%3B May be involved in the transport of PQQ or its precursor to the periplasm%3B Belongs to the PqqB family gene gene1784 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01785 S101447_01786 S101447_01786 S101447_01786 1847627 1848952 + Inner membrane protein YghQ Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix. gene gene1785 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01786 S101447_01787 S101447_01787 S101447_01787 1848945 1849982 + hypothetical protein gene gene1786 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01787 S101447_01788 S101447_01788 S101447_01788 1850104 1851144 + hypothetical protein gene gene1787 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01788 S101447_01789 S101447_01789 pcaD pcaD 1851269 1852087 + 3-oxoadipate enol-lactonase Acetoin catabolism%3B Acyltransferase%3B Lipoyl%3B Transferase%3B Dihydrolipoamide acetyltransferase involved in acetoin catabolism. Contains 1 lipoyl-binding domain%3B KEGG: bxe:Bxe_B0595 3-oxoadipate enol-lactonase gene gene1788 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01789 S101447_01790 S101447_01790 S101447_01790 1852148 1852933 - Exodeoxyribonuclease III DNA damage%3B DNA repair%3B Exonuclease%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nuclease%3B Major apurinic-apyrimidinic endonuclease of E. coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease%2C 3'-phosphomonoesterase%2C 3'-repair diesterase and ribonuclease H activities. Belongs to the DNA repair enzymes AP/ExoA family%3B KEGG: xfa:XF1933 exodeoxyribonuclease III gene gene1789 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01790 S101447_01791 S101447_01791 S101447_01791 1852930 1853298 - uncharacterized protein Belongs to the HesB/IscA family gene gene1790 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01791 S101447_01792 S101447_01792 S101447_01792 1853482 1854642 + dGTPase Hydrolase%3B Belongs to the dGTPase family. Type 2 subfamily%3B KEGG: apt:APA01_21190 dGTPase gene gene1791 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01792 S101447_01793 S101447_01793 rarS rarS 1854690 1856489 + Arginine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: apt:APA01_21180 arginyl-tRNA synthetase gene gene1792 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01793 S101447_01794 S101447_01794 S101447_01794 1856489 1857466 + Serine-type D-Ala-D-Ala carboxypeptidase KEGG: rtr:RTCIAT899_CH04520 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6) gene gene1793 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01794 S101447_01795 S101447_01795 S101447_01795 1857487 1858404 + Segregation and condensation protein Cell cycle%3B Cell division%3B Chromosome partition%3B Cytoplasm%3B Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves%3B Belongs to the ScpA family gene gene1794 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01795 S101447_01796 S101447_01796 S101447_01796 1858401 1859267 + Segregation and condensation protein B like protein Cell cycle%3B Cell division%3B Chromosome partition%3B Cytoplasm%3B May participate in chromosomal partitioning during cell division%3B Belongs to the ScpB family gene gene1795 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01796 S101447_01797 S101447_01797 S101447_01797 1859340 1860008 + Sec-independent protein translocase protein TatB Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Translocation%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC%2C TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation%3B Belongs to the TatB family gene gene1796 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01797 S101447_01798 S101447_01798 S101447_01798 1860005 1860835 + Sec-independent protein translocase protein TatC Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Translocation%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB%2C TatC is part of a receptor directly interacting with Tat signal peptides%3B Belongs to the TatC family gene gene1797 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01798 S101447_01799 S101447_01799 sarS sarS 1860839 1862107 + Serine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine%2C to form the misacylated tRNA L-seryl-tRNA(Sec)%2C which will be further converted into selenocysteinyl-tRNA(Sec)%3B Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily%3B KEGG: mej:Q7A_569 seryl-tRNA synthetase gene gene1798 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01799 S101447_01800 S101447_01800 S101447_01800 1862126 1862464 + Quaternary ammonium compound-resistance protein QacC Cell membrane%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds and ethidium bromide. Belongs to the small multidrug resistance (SMR) protein family gene gene1799 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01800 S101447_01801 S101447_01801 dsbD dsbD 1862461 1864638 - Protein-disulfide reductase KEGG: apt:APA01_21100 thiol:disulfide interchange protein DsbD gene gene1800 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01801 S101447_01802 S101447_01802 S101447_01802 1864747 1864962 - hypothetical protein gene gene1801 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01802 S101447_01803 S101447_01803 mglL mglL 1865140 1866141 + Acylglycerol lipase KEGG: rru:Rru_A0068 acylglycerol lipase gene gene1802 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01803 S101447_01804 S101447_01804 S101447_01804 1866261 1866337 + tRNA-Arg tRNA gene1803 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01804 S101447_01805 S101447_01805 S101447_01805 1866660 1868495 - putative transporter Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the aromatic acid exporter ArAE (TC 2. A. 85) family gene gene1804 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01805 S101447_01806 S101447_01806 S101447_01806 1868617 1869513 - HTH-type transcriptional regulator EstR DNA-binding%3B Transcription%3B Transcription regulation%3B Transcriptional regulator of the esterase operon. Contains 1 HTH lysR-type DNA-binding domain gene gene1805 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01806 S101447_01807 S101447_01807 S101447_01807 1869539 1869958 - 8-oxo-dGTP diphosphatase KEGG: aci:ACIAD3237 8-oxo-dGTP diphosphatase gene gene1806 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01807 S101447_01808 S101447_01808 S101447_01808 1870510 1871997 + 16S ribosomal RNA rRNA gene1807 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01808 S101447_01809 S101447_01809 S101447_01809 1872213 1872289 + tRNA-Ile tRNA gene1808 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01809 S101447_01810 S101447_01810 S101447_01810 1872314 1872389 + tRNA-Ala tRNA gene1809 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01810 S101447_01811 S101447_01811 S101447_01811 1872721 1875462 + 23S ribosomal RNA rRNA gene1810 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01811 S101447_01812 S101447_01812 S101447_01812 1875571 1875686 + 5S ribosomal RNA rRNA gene1811 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01812 S101447_01813 S101447_01813 S101447_01813 1875742 1875818 + tRNA-Met tRNA gene1812 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01813 S101447_01814 S101447_01814 S101447_01814 1876180 1876686 + hypothetical protein gene gene1813 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01814 S101447_01815 S101447_01815 S101447_01815 1876807 1877292 + hypothetical protein gene gene1814 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01815 S101447_01816 S101447_01816 S101447_01816 1877500 1877880 - hypothetical protein gene gene1815 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01816 S101447_01817 S101447_01817 S101447_01817 1877870 1878193 - hypothetical protein gene gene1816 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01817 S101447_01818 S101447_01818 S101447_01818 1878294 1878503 - hypothetical protein gene gene1817 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01818 S101447_01819 S101447_01819 S101447_01819 1878632 1878910 + hypothetical protein gene gene1818 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01819 S101447_01820 S101447_01820 S101447_01820 1878779 1879081 - hypothetical protein gene gene1819 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01820 S101447_01821 S101447_01821 S101447_01821 1879451 1880131 + Site-specific DNA-methyltransferase (adenine-specific) Methyltransferase%3B Plasmid%3B Transferase%3B Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: goh:B932_1748 site-specific DNA-methyltransferase (adenine-specific) gene gene1820 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01821 S101447_01822 S101447_01822 S101447_01822 1880526 1881224 + hypothetical protein gene gene1821 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01822 S101447_01823 S101447_01823 S101447_01823 1881558 1882727 + hypothetical protein gene gene1822 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01823 S101447_01824 S101447_01824 S101447_01824 1883188 1883964 - hypothetical protein gene gene1823 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01824 S101447_01825 S101447_01825 S101447_01825 1884271 1884540 + hypothetical protein gene gene1824 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01825 S101447_01826 S101447_01826 S101447_01826 1884517 1884996 - hypothetical protein gene gene1825 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01826 S101447_01827 S101447_01827 S101447_01827 1885057 1885659 + hypothetical protein gene gene1826 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01827 S101447_01828 S101447_01828 S101447_01828 1885656 1886171 + hypothetical protein gene gene1827 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01828 S101447_01829 S101447_01829 S101447_01829 1886168 1886773 + hypothetical protein gene gene1828 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01829 S101447_01830 S101447_01830 S101447_01830 1886757 1887092 + hypothetical protein gene gene1829 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01830 S101447_01831 S101447_01831 S101447_01831 1887096 1887749 + hypothetical protein gene gene1830 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01831 S101447_01832 S101447_01832 S101447_01832 1887746 1887991 + hypothetical protein gene gene1831 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01832 S101447_01833 S101447_01833 sul1 sul1 1887988 1890039 + Dihydropteroate synthase KEGG: send:DT104_38581 dihydropteroate synthase type 1 gene gene1832 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01833 S101447_01834 S101447_01834 S101447_01834 1890264 1890644 - HTH-type transcriptional activator HxlR Activator%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Positive regulator of hxlAB expression. Contains 1 HTH hxlR-type DNA-binding domain gene gene1833 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01834 S101447_01835 S101447_01835 S101447_01835 1890688 1891500 + 3-oxoacyl-[acyl-carrier-protein] reductase Oxidoreductase%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: kpk:A593_20530 3-oxoacyl-(acyl-carrier protein) reductase gene gene1834 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01835 S101447_01836 S101447_01836 S101447_01836 1891542 1892279 + Hca operon transcriptional activator HcaR Activator%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. Contains 1 HTH lysR-type DNA-binding domain gene gene1835 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01836 S101447_01837 S101447_01837 S101447_01837 1892279 1892572 + hypothetical protein gene gene1836 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01837 S101447_01838 S101447_01838 S101447_01838 1892792 1893016 - hypothetical protein gene gene1837 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01838 S101447_01839 S101447_01839 S101447_01839 1893066 1893383 - hypothetical protein gene gene1838 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01839 S101447_01840 S101447_01840 S101447_01840 1893456 1893752 + hypothetical protein gene gene1839 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01840 S101447_01841 S101447_01841 S101447_01841 1893870 1895858 + Conjugal transfer protein TraG Cell inner membrane%3B Cell membrane%3B Conjugation%3B DNA-binding%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Required for conjugative transfer of plasmid RP4. Binds tightly and specifically to the relaxase TraI. Can also bind to DNA without sequence specificity. May form a pore-like structure that could serve as a channel for DNA transfer. Belongs to the VirD4/TraG family gene gene1840 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01841 S101447_01842 S101447_01842 S101447_01842 1895885 1896304 + hypothetical protein gene gene1841 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01842 S101447_01843 S101447_01843 S101447_01843 1896477 1897481 + Conjugal transfer protein TrbB ATP-binding%3B Conjugation%3B Cytoplasm%3B Nucleotide-binding%3B Plasmid%3B Transport%3B Belongs to the GSP E family gene gene1842 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01843 S101447_01844 S101447_01844 S101447_01844 1897478 1897846 + Conjugal transfer protein TrbC Cell membrane%3B Conjugation%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Belongs to the TrbC family gene gene1843 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01844 S101447_01845 S101447_01845 S101447_01845 1897846 1898121 + hypothetical protein gene gene1844 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01845 S101447_01846 S101447_01846 S101447_01846 1898135 1900576 + putative conjugal transfer protein TrbE part Conjugation%3B Plasmid%3B Belongs to the TrbE/VirB4 family gene gene1845 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01846 S101447_01847 S101447_01847 S101447_01847 1900573 1901307 + hypothetical protein gene gene1846 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01847 S101447_01848 S101447_01848 S101447_01848 1901313 1902728 + Epstein-Barr nuclear antigen Activator%3B DNA-binding%3B Host nucleus%3B Host-virus interaction%3B Inhibition of host adaptive immune response by virus%3B Inhibition of host NF-kappa-B by virus%3B Inhibition of host proteasome antigen processing by virus%3B Transcription%3B Transcription regulation%3B Viral immunoevasion%3B Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase%2C the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication%2C oriP. Additionally%2C it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally%2C it can counteract the stabilization of host p53/TP53 by host USP7%2C thereby decreasing apoptosis and increasing host cell survival (By similarity)%3B Belongs to the herpesviridae EBNA1 family gene gene1847 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01848 S101447_01849 S101447_01849 S101447_01849 1902734 1903417 + hypothetical protein gene gene1848 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01849 S101447_01850 S101447_01850 S101447_01850 1903414 1904415 + Conjugal transfer protein TrbG Conjugation%3B Plasmid%3B Signal%3B Belongs to the TrbG/VirB9 family gene gene1849 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01850 S101447_01851 S101447_01851 S101447_01851 1904412 1905611 + Conjugal transfer protein TrbI Conjugation%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Belongs to the TrbI/VirB10 family gene gene1850 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01851 S101447_01852 S101447_01852 S101447_01852 1905608 1905847 + hypothetical protein gene gene1851 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01852 S101447_01853 S101447_01853 S101447_01853 1906062 1907780 + Site-specific DNA-methyltransferase (adenine-specific) Methyltransferase%3B Plasmid%3B Restriction system%3B S-adenosyl-L-methionine%3B Transferase%3B This methylase recognizes the double-stranded sequence CTCGAG%2C causes specific methylation on A-5 on both strands%2C and protects the DNA from cleavage by the PaeR7I endonuclease%3B Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: ccc:G157_07120 adenine-specific DNA-methyltransferase gene gene1852 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01853 S101447_01854 S101447_01854 S101447_01854 1907780 1908526 + Type II site-specific deoxyribonuclease Endonuclease%3B Hydrolase%3B Nuclease%3B Restriction system%3B Recognizes the double-stranded sequence CTCGAG and cleaves after C-1. Belongs to the type II restriction enzyme XhoI family%3B KEGG: vei:Veis_0524 type II restriction enzyme gene gene1853 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01854 S101447_01855 S101447_01855 S101447_01855 1908536 1909858 + hypothetical protein gene gene1854 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01855 S101447_01856 S101447_01856 S101447_01856 1909855 1912038 + putative helicase ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Plasmid%3B Belongs to the HerA family gene gene1855 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01856 S101447_01857 S101447_01857 S101447_01857 1912212 1912340 - hypothetical protein gene gene1856 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01857 S101447_01858 S101447_01858 S101447_01858 1912462 1913844 - hypothetical protein gene gene1857 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01858 S101447_01859 S101447_01859 S101447_01859 1914540 1914725 - hypothetical protein gene gene1858 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01859 S101447_01860 S101447_01860 S101447_01860 1915594 1916193 + hypothetical protein gene gene1859 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01860 S101447_01861 S101447_01861 S101447_01861 1916543 1918072 + hypothetical protein gene gene1860 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01861 S101447_01862 S101447_01862 S101447_01862 1918110 1918535 - uncharacterized protein Plasmid. gene gene1861 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01862 S101447_01863 S101447_01863 S101447_01863 1918583 1918939 + Antitoxin VapB DNA-binding%3B Plasmid%3B Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in E. coli neutralizes the effect of cognate toxin VapC. The VapB/VapC complex probably regulates transcription of its own promoter%3B Belongs to the VapB family%3B Contains 1 SpoVT-AbrB domain gene gene1862 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01863 S101447_01864 S101447_01864 mvpA mvpA 1918940 1919350 + Ribonuclease VapC2 Hydrolase%3B Magnesium%3B Metal-binding%3B Nuclease%3B Toxin%3B Toxic component of a toxin-antitoxin (TA) module. An RNase. Its cognate antitoxin is VapB2 (By similarity)%3B Belongs to the PINc/VapC protein family%3B Contains 1 PINc domain%3B KEGG: eoj:ECO26_3520 tRNA(fMet)-specific endonuclease VapC%3B Acting on ester bonds gene gene1863 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01864 S101447_01865 S101447_01865 S101447_01865 1919834 1922440 + hypothetical protein gene gene1864 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01865 S101447_01866 S101447_01866 S101447_01866 1922562 1922951 + hypothetical protein gene gene1865 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01866 S101447_01867 S101447_01867 S101447_01867 1923024 1925330 + hypothetical protein gene gene1866 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01867 S101447_01868 S101447_01868 S101447_01868 1925349 1925954 - Protein SCO1 like protein%2C mitochondrial Chaperone%3B Copper%3B Metal-binding%3B Mitochondrion%3B Transit peptide%3B Thought to play a role in cellular copper homeostasis%2C mitochondrial redox signaling or insertion of copper into the active site of COX%3B Belongs to the SCO1/2 family gene gene1867 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01868 S101447_01869 S101447_01869 mhpA mhpA 1926193 1927662 + 3-(3-hydroxy-phenyl)propanoic acid hydroxylase Aromatic hydrocarbons catabolism%3B FAD%3B Flavoprotein%3B Monooxygenase%3B NADP%3B Oxidoreductase%3B Dechlorination of pentachlorophenol to tetrachlorohydroquinone. Removes also hydrogen and nitro%2C amino%2C and cyano groups from benzene ring at the para position in relation to the hydroxyl of phenol%3B Belongs to the PheA/TfdB FAD monooxygenase family%3B KEGG: bxe:Bxe_B1226 3-(3-hydroxy-phenyl)propionate hydroxylase gene gene1868 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01869 S101447_01870 S101447_01870 poxB poxB 1927844 1929631 + Pyruvate dehydrogenase (quinone) FAD%3B Flavoprotein%3B Magnesium%3B Metal-binding%3B Oxidoreductase%3B Thiamine pyrophosphate%3B Important for the aerobic growth. Decarboxylates pyruvate in four steps. The energy released is partially stored in acetyl phosphate. Belongs to the TPP enzyme family%3B KEGG: bra:BRADO6324 pyruvate dehydrogenase (quinone) gene gene1869 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01870 S101447_01871 S101447_01871 S101447_01871 1929702 1930556 - putative oxidoreductase YhxD Oxidoreductase%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: ctu:CTU_22800 null%3B Oxidoreductases gene gene1870 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01871 S101447_01872 S101447_01872 S101447_01872 1930638 1930940 - hypothetical protein gene gene1871 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01872 S101447_01873 S101447_01873 treX treX 1931075 1933195 - Glycogen debranching enzyme Carbohydrate metabolism%3B Glycogen metabolism%3B Glycosidase%3B Hydrolase%3B Hydrolyzes the alpha-1%2C6-glucosidic linkages in glycogen which has first been partially depolymerized by phosphorylase. Shows only very little activity with native glycogen%3B Belongs to the glycosyl hydrolase 13 family%3B KEGG: apt:APA01_20830 glycogen operon protein%3B Glycosidases%2C i. e. enzymes hydrolyzing O- and S-glycosyl compounds gene gene1872 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01873 S101447_01874 S101447_01874 glgA glgA 1933425 1935053 + Starch synthase Glycogen biosynthesis%3B Glycosyltransferase%3B Transferase%3B Synthesizes alpha-1%2C4-glucan chains using ADP-glucose%3B Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily%3B KEGG: apt:APA01_20820 starch synthase gene gene1873 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01874 S101447_01875 S101447_01875 glgB glgB 1935102 1937330 + 1%2C4-alpha-glucan branching enzyme Carbohydrate metabolism%3B Glycogen biosynthesis%3B Glycogen metabolism%3B Glycosyltransferase%3B Transferase%3B Catalyzes the formation of the alpha-1%2C6-glucosidic linkages in glycogen by scission of a 1%2C4-alpha-linked oligosaccharide from growing alpha-1%2C4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1%2C6 position%3B Belongs to the glycosyl hydrolase 13 family. GlgB subfamily%3B KEGG: apt:APA01_20810 1%2C4-alpha-glucan branching enzyme gene gene1874 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01875 S101447_01876 S101447_01876 treZ treZ 1937363 1939120 + 4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase Carbohydrate metabolism%3B Cytoplasm%3B Glycosidase%3B Hydrolase%3B Belongs to the glycosyl hydrolase 13 family%3B KEGG: apt:APA01_20800 maltooligosyltrehalose trehalohydrolase gene gene1875 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01876 S101447_01877 S101447_01877 treY treY 1939117 1941744 + (1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase Isomerase%3B Catalyzes the conversion of maltooligosaccharide into the non-reducing saccharide%2C maltooligosyl trehalose (alpha- maltooligosyl alpha-D-glucoside) by intramolecular transglycosylation. Belongs to the glycosyl hydrolase 13 family%3B KEGG: pfl:PFL_2884 (1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase gene gene1876 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01877 S101447_01878 S101447_01878 S101447_01878 1941853 1942698 + 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase NAD%3B Oxidoreductase%3B Catalyzes the reduction of 2%2C5-diketo-3-deoxygluconate (DKII or 4%2C6-dihydroxy-2%2C5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: gox:GOX1538 null%3B With NAD(+) or NADP(+) as acceptor gene gene1877 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01878 S101447_01879 S101447_01879 S101447_01879 1942800 1944158 - Asparaginyl-tRNA synthase (glutamine-hydrolyzing) Hydrolase%3B Plasmid%3B Hydrolyzes biuret to allophanate and NH(3)%3B Belongs to the amidase family%3B KEGG: apt:APA01_20770 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A gene gene1878 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01879 S101447_01880 S101447_01880 S101447_01880 1944317 1945258 - putative hydrogen peroxide-inducible protein activator Activator%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Required for the induction the katG gene for catalase. Involved in the response to hydrogen peroxide (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1879 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01880 S101447_01881 S101447_01881 aspB aspB 1945611 1946813 + Aspartate transaminase Aminotransferase%3B Cytoplasm%3B Pyridoxal phosphate%3B Transferase%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: gxl:H845_1427 aspartate aminotransferase gene gene1880 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01881 S101447_01882 S101447_01882 S101447_01882 1946909 1947373 - hypothetical protein gene gene1881 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01882 S101447_01883 S101447_01883 accC accC 1947342 1948739 - Acetyl-CoA carboxylase ATP-binding%3B Biotin%3B Ligase%3B Magnesium%3B Nucleotide-binding%3B Contains 1 ATP-grasp domain%3B Contains 1 biotin carboxylation domain%3B KEGG: apt:APA01_20730 acetyl-CoA carboxylase%2C biotin carboxylase subunit gene gene1882 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01883 S101447_01884 S101447_01884 S101447_01884 1948736 1949185 - Biotin carboxyl carrier protein of acetyl-CoA carboxylase Biotin%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B This protein is a component of the acetyl coenzyme A carboxylase comple%3B first%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA%3B Contains 1 biotinyl-binding domain gene gene1883 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01884 S101447_01885 S101447_01885 S101447_01885 1949198 1949950 - putative short-chain type dehydrogenase/reductase Oxidoreductase%3B Plasmid%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: pst:PSPTO_2916 null%3B Oxidoreductases gene gene1884 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01885 S101447_01886 S101447_01886 S101447_01886 1950280 1950981 + uncharacterized protein To H. influenzae HI_1731%3B To B. subtilis YcsJ and yeast urea amidolyase (DUR1%2C2) gene gene1885 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01886 S101447_01887 S101447_01887 S101447_01887 1950978 1951979 + Allophanate hydrolase Sporulation%3B Counteracts the inhibitory action of KipI on sporulation. May bind to KipI%2C preventing its function as an inhibitor of kinase A%3B KEGG: hne:HNE_2123 allophanate hydrolase gene gene1886 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01887 S101447_01888 S101447_01888 S101447_01888 1951976 1952737 + UPF0271 protein Belongs to the UPF0271 (lamB) family gene gene1887 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01888 S101447_01889 S101447_01889 S101447_01889 1952856 1953734 + S-adenosylmethionine uptake transporter Amino-acid transport%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Transports S-adenosylmethionine%3B Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2. A. 7. 3) family%3B Contains 2 EamA domains gene gene1888 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01889 S101447_01890 S101447_01890 S101447_01890 1953905 1955125 + putative galactarate transporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Uptake of D-galactarate%3B Belongs to the major facilitator superfamily. Phthalate permease family gene gene1889 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01890 S101447_01891 S101447_01891 S101447_01891 1955375 1957846 + hypothetical protein gene gene1890 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01891 S101447_01892 S101447_01892 S101447_01892 1957950 1958708 + Proline-rich extensin-like protein EPR1 Cell wall%3B Cell wall biogenesis/degradation%3B Repeat%3B Secreted%3B Signal%3B May have a specific role in modifying the cell-wall structure%2C specifically during seed germination%2C thus facilitating radicle protrusion%3B Belongs to the extensin family gene gene1891 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01892 S101447_01893 S101447_01893 S101447_01893 1958817 1959794 + hypothetical protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-independent uptake of proteins%3B Belongs to the ExbB/TolQ family gene gene1892 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01893 S101447_01894 S101447_01894 S101447_01894 1959824 1960243 + Biopolymer transport protein ExbD Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates%3B Belongs to the ExbD/TolR family gene gene1893 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01894 S101447_01895 S101447_01895 S101447_01895 1960298 1960738 + Biopolymer transport protein exbD1 Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates%3B Belongs to the ExbD/TolR family gene gene1894 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01895 S101447_01896 S101447_01896 S101447_01896 1960815 1960976 - hypothetical protein gene gene1895 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01896 S101447_01897 S101447_01897 S101447_01897 1961238 1962164 - HTH-type transcriptional activator AaeR Activator%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Activates transcription of the aaeXAB operon%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1896 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01897 S101447_01898 S101447_01898 S101447_01898 1962285 1963154 + Putative quercetin 2%2C3-dioxygenase Dioxygenase%3B Metal-binding%3B Oxidoreductase%3B Putative quercetin 2%2C3-dioxygenase%3B Belongs to the pirin family gene gene1897 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01898 S101447_01899 S101447_01899 frdA frdA 1963254 1963835 + Fumarate reductase (quinol) Flavoprotein%3B FMN%3B NAD%3B Oxidoreductase%3B Involved in the protection against chromate toxicity. Catalyzes the transfer of three electrons to Cr(6+) producing Cr(3+) and one electron to molecular oxygen without producing the toxic Cr(5+) species and only producing a minimal amount of reactive oxygen species (ROS) (By similarity)%3B Belongs to the SsuE family%3B KEGG: cama:F384_13015 fumarate reductase flavoprotein subunit gene gene1898 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01899 S101447_01900 S101447_01900 S101447_01900 1964000 1964401 + putative 15.0 kDa protein in dhaT-dhaS intergenic region Belongs to the GlcG family gene gene1899 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01900 S101447_01901 S101447_01901 S101447_01901 1964426 1965661 + putative MFS-type transporter YbcL Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the major facilitator superfamily gene gene1900 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01901 S101447_01902 S101447_01902 S101447_01902 1966115 1967506 + Succinate-semialdehyde dehydrogenase (NAD(P)(+)) NADP%3B Oxidoreductase%3B Catalyzes the NADP(+) dependent oxidation of succinate semialdehyde to succinate%3B Belongs to the aldehyde dehydrogenase family%3B KEGG: ecle:ECNIH2_24840 succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase gene gene1901 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01902 S101447_01903 S101447_01903 S101447_01903 1967686 1968978 + NADH dehydrogenase Cell membrane%3B Electron transport%3B FAD%3B Flavoprotein%3B Membrane%3B NAD%3B Oxidoreductase%3B Transport%3B Ubiquinone%3B Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation (By similarity)%3B Belongs to the NADH dehydrogenase family%3B KEGG: goy:GLS_c05650 NADH dehydrogenase gene gene1902 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01903 S101447_01904 S101447_01904 S101447_01904 1968950 1969582 - Transcriptional regulator AcuR DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B A transcriptional repressor for its operon. Probably binds to 2 operator sequences in the promoter%3B Contains 1 HTH tetR-type DNA-binding domain gene gene1903 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01904 S101447_01905 S101447_01905 S101447_01905 1969838 1970722 + 8-oxo-dGTP diphosphatase KEGG: vap:Vapar_6281 8-oxo-dGTP diphosphatase gene gene1904 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01905 S101447_01906 S101447_01906 nadA nadA 1970803 1971783 + Quinolinate synthase 4Fe-4S%3B Cytoplasm%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Plasmid%3B Pyridine nucleotide biosynthesis%3B Transferase%3B Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate%3B Belongs to the quinolinate synthase A family. Type 2 subfamily%3B KEGG: apt:APA01_20500 quinolinate synthase gene gene1905 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01906 S101447_01907 S101447_01907 nadC nadC 1971810 1972667 + Nicotinate-nucleotide diphosphorylase (carboxylating) Chloroplast%3B Glycosyltransferase%3B Plastid%3B Pyridine nucleotide biosynthesis%3B Transferase%3B Transit peptide%3B Involved in the catabolism of quinolinic acid (QA)%3B Belongs to the NadC/ModD family%3B KEGG: apt:APA01_20490 nicotinate-nucleotide pyrophosphorylase (carboxylating) gene gene1906 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01907 S101447_01908 S101447_01908 S101447_01908 1972714 1973721 - hypothetical protein gene gene1907 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01908 S101447_01909 S101447_01909 S101447_01909 1973718 1975196 - uncharacterized protein To M. tuberculosis RV2411c%3B KEGG: ams:AMIS_65960 carboxylate-amine ligase%3B Forming carbon-nitrogen bonds gene gene1908 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01909 S101447_01910 S101447_01910 S101447_01910 1975444 1976280 + hypothetical protein gene gene1909 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01910 S101447_01911 S101447_01911 S101447_01911 1976277 1977353 + uncharacterized protein gene gene1910 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01911 S101447_01912 S101447_01912 S101447_01912 1977463 1979178 - D-lactate dehydrogenase Cell membrane%3B FAD%3B Flavoprotein%3B Membrane%3B NAD%3B Oxidoreductase%3B First component of the membrane-bound D-lactate oxidase%2C which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids. Contains 1 FAD-binding PCMH-type domain%3B KEGG: apt:APA01_20440 D-lactate dehydrogenase gene gene1911 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01912 S101447_01913 S101447_01913 S101447_01913 1979434 1980885 + Aldehyde dehydrogenase (NAD(+)) NAD%3B Oxidoreductase%3B Belongs to the aldehyde dehydrogenase family%3B KEGG: apt:APA01_20430 aldehyde dehydrogenase (NAD+) gene gene1912 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01913 S101447_01914 S101447_01914 S101447_01914 1981078 1981839 + 3(or 17)-beta-hydroxysteroid dehydrogenase Aromatic hydrocarbons catabolism%3B NAD%3B Oxidoreductase%3B Catalyzes the degradation of 2%2C5-dichloro-2%2C5- cyclohexadiene-1%2C4-diol (2%2C5-DDOL) into 2%2C5-dichlorohydroquinone (2%2C5-DCHQ). LinX appears not to be involved in gamma-HCH degradation pathway. Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: bur:Bcep18194_B1514 3(or 17)beta-hydroxysteroid dehydrogenase gene gene1913 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01914 S101447_01915 S101447_01915 S101447_01915 1981888 1982106 + hypothetical protein gene gene1914 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01915 S101447_01916 S101447_01916 S101447_01916 1982176 1982646 - Cytochrome c-552 Electron transport%3B Heme%3B Iron%3B Metal-binding%3B Pyrrolidone carboxylic acid%3B Signal%3B Transport. gene gene1915 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01916 S101447_01917 S101447_01917 S101447_01917 1983040 1983115 - tRNA-Phe tRNA gene1916 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01917 S101447_01918 S101447_01918 S101447_01918 1983171 1983356 - DNA gyrase inhibitor YacG Metal-binding%3B Zinc%3B Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB%2C which probably disrupts DNA binding by the gyrase%3B Belongs to the DNA gyrase inhibitor YacG family gene gene1917 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01918 S101447_01919 S101447_01919 S101447_01919 1983353 1984438 - hypothetical protein gene gene1918 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01919 S101447_01920 S101447_01920 S101447_01920 1984435 1985067 - Maf-like protein Cytoplasm%3B Belongs to the maf family gene gene1919 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01920 S101447_01921 S101447_01921 S101447_01921 1985072 1985290 - Translation initiation factor IF-1 Cytoplasm%3B Initiation factor%3B Protein biosynthesis%3B RNA-binding%3B rRNA-binding%3B One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection%2C yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1%2C IF-2 and IF-3 are released leaving the mature 70S translation initation complex%3B Belongs to the IF-1 family%3B Contains 1 S1-like domain gene gene1920 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01921 S101447_01922 S101447_01922 hisD hisD 1985365 1986678 - Histidinol dehydrogenase Amino-acid biosynthesis%3B Histidine biosynthesis%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Zinc%3B Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine%3B Belongs to the histidinol dehydrogenase family%3B KEGG: tni:TVNIR_2626 histidinol dehydrogenase gene gene1921 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01922 S101447_01923 S101447_01923 hisG hisG 1986693 1987424 - ATP phosphoribosyltransferase Amino-acid biosynthesis%3B ATP-binding%3B Cytoplasm%3B Glycosyltransferase%3B Histidine biosynthesis%3B Nucleotide-binding%3B Transferase%3B Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity%3B Belongs to the ATP phosphoribosyltransferase family. Short subfamily%3B KEGG: apt:APA01_19880 ATP phosphoribosyltransferase gene gene1922 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01923 S101447_01924 S101447_01924 S101447_01924 1987600 1990446 - Ribonuclease E Cell inner membrane%3B Cell membrane%3B Cytoplasm%3B Endonuclease%3B Hydrolase%3B Magnesium%3B Membrane%3B Metal-binding%3B Nuclease%3B RNA-binding%3B rRNA processing%3B tRNA processing%3B Zinc%3B Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs%3B Belongs to the RNase E/G family. RNase E subfamily%3B Contains 1 S1 motif domain%3B KEGG: pgb:H744_2c2625 ribonuclease E gene gene1923 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01924 S101447_01925 S101447_01925 amiA amiA 1990938 1991837 + N-acetylmuramoyl-L-alanine amidase Cell wall biogenesis/degradation%3B Hydrolase%3B Periplasm%3B Signal%3B Cell-wall hydrolase involved in septum cleavage during cell division%3B Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family%3B KEGG: apt:APA01_19860 N-acetylmuramoyl-L-alanine amidase gene gene1924 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01925 S101447_01926 S101447_01926 S101447_01926 1991801 1992739 - hypothetical protein gene gene1925 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01926 S101447_01927 S101447_01927 S101447_01927 1992880 1992966 - tRNA-Leu tRNA gene1926 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01927 S101447_01928 S101447_01928 S101447_01928 1993148 1994101 + NADH:ubiquinone reductase (H(+)-translocating) Electron transport%3B FAD%3B Flavoprotein%3B Mitochondrion%3B Respiratory chain%3B Transit peptide%3B Transport%3B Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I)%2C that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I NDUFA9 subunit family%3B KEGG: apt:APA01_19830 NADH dehydrogenase gene gene1927 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01928 S101447_01929 S101447_01929 S101447_01929 1994296 1995744 + Glutamate synthase (NADPH) 4Fe-4S%3B Amino-acid biosynthesis%3B Glutamate biosynthesis%3B Iron%3B Iron-sulfur%3B Metal-binding%3B NADP%3B Oxidoreductase%3B Contains 1 4Fe-4S ferredoxin-type domain%3B KEGG: apb:SAR116_1241 glutamate synthase (NADPH/NADH) small chain%3B overlaps another CDS with the same product name gene gene1928 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01929 S101447_01930 S101447_01930 gltB gltB 1995744 2000300 + Glutamate synthase (NADPH) 3Fe-4S%3B Amino-acid biosynthesis%3B FAD%3B Flavoprotein%3B FMN%3B Glutamate biosynthesis%3B Glutamine amidotransferase%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Oxidoreductase%3B Belongs to the glutamate synthase family%3B Contains 1 glutamine amidotransferase type-2 domain%3B KEGG: apt:APA01_19810 glutamate synthase (NADPH/NADH) large chain%3B overlaps another CDS with the same product name gene gene1929 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01930 S101447_01931 S101447_01931 pepF pepF 2000449 2002299 + Oligoendopeptidase F%2C plasmid Hydrolase%3B Metal-binding%3B Metalloprotease%3B Plasmid%3B Protease%3B Zinc%3B Hydrolyzes peptides containing between 7 and 17 amino acids with a rather wide specificity. Belongs to the peptidase M3B family%3B KEGG: apt:APA01_19800 oligoendopeptidase F%3B Metalloendopeptidases gene gene1930 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01931 S101447_01932 S101447_01932 S101447_01932 2002302 2003666 + uncharacterized protein Belongs to the protein kinase superfamily. ADCK protein kinase family gene gene1931 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01932 S101447_01933 S101447_01933 S101447_01933 2003726 2004316 - hypothetical protein gene gene1932 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01933 S101447_01934 S101447_01934 ispH ispH 2004553 2005554 + 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3Fe-4S%3B Iron%3B Iron-sulfur%3B Isoprene biosynthesis%3B Metal-binding%3B NADP%3B Oxidoreductase%3B Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)%3B Belongs to the IspH family%3B KEGG: apt:APA01_19770 4-hydroxy-3-methylbut-2-enyl diphosphate reductase gene gene1933 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01934 S101447_01935 S101447_01935 S101447_01935 2005564 2006538 + Homoserine kinase Amino-acid biosynthesis%3B ATP-binding%3B Kinase%3B Nucleotide-binding%3B Threonine biosynthesis%3B Transferase%3B Belongs to the pseudomonas-type ThrB family%3B KEGG: mej:Q7A_2478 homoserine kinase type II gene gene1934 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01935 S101447_01936 S101447_01936 rnhA rnhA 2006522 2007016 + Ribonuclease H Cytoplasm%3B Endonuclease%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nuclease%3B Endonuclease that specifically degrades the RNA of RNA- DNA hybrids%3B Belongs to the RNase H family%3B Contains 1 RNase H domain%3B KEGG: apt:APA01_19750 ribonuclease HI gene gene1935 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01936 S101447_01937 S101447_01937 S101447_01937 2007048 2008565 + hypothetical protein gene gene1936 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01937 S101447_01938 S101447_01938 S101447_01938 2008577 2009602 - Vegetative cell wall protein gp1 Glycoprotein%3B Repeat%3B Signal. gene gene1937 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01938 S101447_01939 S101447_01939 ppnK ppnK 2009599 2010414 - NAD(+) kinase ATP-binding%3B Cytoplasm%3B Kinase%3B NAD%3B NADP%3B Nucleotide-binding%3B Transferase%3B Involved in the regulation of the intracellular balance of NAD and NADP%2C and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP%3B Belongs to the NAD kinase family%3B KEGG: apt:APA01_19720 NAD+ kinase gene gene1938 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01939 S101447_01940 S101447_01940 mshA mshA 2010464 2011693 - D-inositol-3-phosphate glycosyltransferase KEGG: cmd:B841_02050 D-inositol-3-phosphate glycosyltransferase gene gene1939 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01940 S101447_01941 S101447_01941 S101447_01941 2011812 2012645 + hypothetical protein gene gene1940 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01941 S101447_01942 S101447_01942 S101447_01942 2012642 2013598 + Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase KEGG: hor:Hore_18890 3-deoxy-D-manno-octulosonic-acid transferase gene gene1941 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01942 S101447_01943 S101447_01943 tarS tarS 2013644 2015575 + Threonine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Metal-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B Zinc%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: par:Psyc_2098 threonyl-tRNA synthetase gene gene1942 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01943 S101447_01944 S101447_01944 S101447_01944 2015778 2016266 + Translation initiation factor IF-3 Cytoplasm%3B Initiation factor%3B Protein biosynthesis%3B IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits%2C thus enhancing the availability of 30S subunits on which protein synthesis initiation begins%3B Belongs to the IF-3 family gene gene1943 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01944 S101447_01945 S101447_01945 S101447_01945 2016336 2017046 - hypothetical protein gene gene1944 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01945 S101447_01946 S101447_01946 S101447_01946 2017245 2018126 - Sensor protein CopS ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Copper%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Plasmid%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system%3B Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon copABCD. Specifically recognizes or transduces a signal only in response to copper. This would lead to phosphorylation of CopR in the cytoplasm. CopS/CopR may also regulate chromosomally encoded genes. May also be involved in basic copper metabolism. Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: hne:HNE_1311 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene1945 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01946 S101447_01947 S101447_01947 S101447_01947 2018209 2018886 - Transcriptional regulatory protein CusR Activator%3B Copper%3B Cytoplasm%3B DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system%3B Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions%2C and probably silver ions (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1946 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01947 S101447_01948 S101447_01948 S101447_01948 2018962 2020086 - UPF0118 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0118 (PerM) family gene gene1947 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01948 S101447_01949 S101447_01949 S101447_01949 2020272 2022161 - putative ABC transporter ATP-binding protein ATP-binding%3B Nucleotide-binding%3B Repeat%3B Transport%3B Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily%3B Contains 2 ABC transporter domains gene gene1948 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01949 S101447_01950 S101447_01950 S101447_01950 2022297 2022719 + Nucleoside-diphosphate kinase ATP-binding%3B Cytoplasm%3B Kinase%3B Magnesium%3B Metal-binding%3B Nucleotide metabolism%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism%2C using a phosphorylated active-site intermediate%3B Belongs to the NDK family%3B KEGG: bfl:Bfl533 nucleoside-diphosphate kinase gene gene1949 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01950 S101447_01951 S101447_01951 S101447_01951 2022979 2024538 + Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase Iron%3B Iron-sulfur%3B Metal-binding%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Required for methylation of hopanoids at the C-3 position%3B Belongs to the radical SAM superfamily%3B Contains 1 B12-binding domain%3B KEGG: fra:Francci3_2496 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase gene gene1950 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01951 S101447_01952 S101447_01952 S101447_01952 2024562 2025209 - uncharacterized protein Plasmid%3B Signal. gene gene1951 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01952 S101447_01953 S101447_01953 S101447_01953 2025358 2025570 + Copper-exporting P-type ATPase ATP-binding%3B Cell membrane%3B Copper%3B Copper transport%3B Hydrolase%3B Ion transport%3B Magnesium%3B Membrane%3B Metal-binding%3B Nucleotide-binding%3B Phosphoprotein%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in copper export%3B Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily%3B Contains 2 HMA domains gene gene1952 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01953 S101447_01954 S101447_01954 S101447_01954 2025744 2026043 + hypothetical protein gene gene1953 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01954 S101447_01955 S101447_01955 S101447_01955 2026058 2026621 - hypothetical protein gene gene1954 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01955 S101447_01956 S101447_01956 gluQ gluQ 2026814 2027725 + Glutamate--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: apt:APA01_19550 glutamyl-Q tRNA(Asp) synthetase%3B Ligases forming aminoacyl-tRNA and related compounds gene gene1955 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01956 S101447_01957 S101447_01957 S101447_01957 2027734 2029092 + Aspartate transaminase Aminotransferase%3B Cytoplasm%3B Pyridoxal phosphate%3B Transferase%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: apt:APA01_19540 aspartate aminotransferase gene gene1956 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01957 S101447_01958 S101447_01958 S101447_01958 2029096 2030301 + Aspartate transaminase Aminotransferase%3B Cytoplasm%3B Pyridoxal phosphate%3B Transferase%3B Involved in symbiotic nitrogen fixation%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: apt:APA01_19530 aspartate aminotransferase gene gene1957 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01958 S101447_01959 S101447_01959 S101447_01959 2030349 2031383 - hypothetical protein gene gene1958 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01959 S101447_01960 S101447_01960 S101447_01960 2031505 2031580 + tRNA-Asn tRNA gene1959 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01960 S101447_01961 S101447_01961 S101447_01961 2031692 2032048 - 2-iminobutanoate/2-iminopropanoate deaminase Belongs to the RutC family%3B KEGG: wvi:Weevi_1446 2-iminobutanoate/2-iminopropanoate deaminase gene gene1960 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01961 S101447_01962 S101447_01962 panC panC 2032098 2032937 - Pantoate--beta-alanine ligase (AMP-forming) ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Pantothenate biosynthesis%3B Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate%3B Belongs to the pantothenate synthetase family%3B KEGG: apt:APA01_19480 pantoate--beta-alanine ligase gene gene1961 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01962 S101447_01963 S101447_01963 dnaE dnaE 2033139 2036558 + DNA-directed DNA polymerase Cytoplasm%3B DNA replication%3B DNA-directed DNA polymerase%3B Nucleotidyltransferase%3B Transferase%3B DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity)%3B Belongs to the DNA polymerase type-C family. DnaE subfamily%3B KEGG: apt:APA01_19490 DNA polymerase III subunit alpha gene gene1962 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01963 S101447_01964 S101447_01964 pabB pabB 2036561 2037946 + Aminodeoxychorismate synthase Antibiotic biosynthesis%3B Folate biosynthesis%3B Glutamine amidotransferase%3B Multifunctional enzyme%3B Transferase%3B Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. In the C-terminal sectio%3B belongs to the anthranilate synthase component I family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: gxl:H845_3180 para-aminobenzoate synthetase component I gene gene1963 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01964 S101447_01965 S101447_01965 S101447_01965 2037943 2038743 + D-amino-acid transaminase Amino-acid biosynthesis%3B Aminotransferase%3B Branched-chain amino acid biosynthesis%3B Pyridoxal phosphate%3B Transferase%3B Acts on leucine%2C isoleucine and valine%3B Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: pat:Patl_4024 D-alanine transaminase gene gene1964 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01965 S101447_01966 S101447_01966 S101447_01966 2038815 2039210 + hypothetical protein gene gene1965 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01966 S101447_01967 S101447_01967 S101447_01967 2039520 2040647 + Benzene 1%2C2-dioxygenase subunit alpha 2Fe-2S%3B Aromatic hydrocarbons catabolism%3B Dioxygenase%3B Iron%3B Iron-sulfur%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Plasmid%3B Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family%3B Contains 1 Rieske domain%3B KEGG: bxe:Bxe_B0203 null%3B Acting on paired donors%2C with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O(2) gene gene1966 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01967 S101447_01968 S101447_01968 S101447_01968 2040813 2041619 + 30S ribosomal protein S2 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein S2P family gene gene1967 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01968 S101447_01969 S101447_01969 S101447_01969 2041754 2042659 + Elongation factor Ts Cytoplasm%3B Elongation factor%3B Protein biosynthesis%3B Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA. EF- Tu. GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)%3B Belongs to the EF-Ts family gene gene1968 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01969 S101447_01970 S101447_01970 S101447_01970 2042675 2043466 + DNA repair protein RecO DNA damage%3B DNA recombination%3B DNA repair%3B Involved in DNA repair and RecF pathway recombination%3B Belongs to the RecO family gene gene1969 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01970 S101447_01971 S101447_01971 parC parC 2043545 2045749 + DNA gyrase subunit ATP-binding%3B Cytoplasm%3B DNA-binding%3B Isomerase%3B Nucleotide-binding%3B Topoisomerase%3B DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings%3B Belongs to the topoisomerase GyrA/ParC subunit family%3B KEGG: apt:APA01_19400 topoisomerase IV subunit A%3B Other isomerases gene gene1970 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01971 S101447_01972 S101447_01972 ate1 ate1 2045760 2046533 - Arginyltransferase Acyltransferase%3B Cytoplasm%3B Transferase%3B May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate%3B Belongs to the R-transferase family%3B KEGG: apt:APA01_19390 arginine-tRNA-protein transferase gene gene1971 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01972 S101447_01973 S101447_01973 hemB hemB 2046608 2047612 - Porphobilinogen synthase Heme biosynthesis%3B Lyase%3B Magnesium%3B Metal-binding%3B Porphyrin biosynthesis%3B Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit%2C each at a distinct site%2C and catalyzes their condensation to form porphobilinogen (By similarity)%3B Belongs to the ALAD family%3B KEGG: apt:APA01_19380 porphobilinogen synthase gene gene1972 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01973 S101447_01974 S101447_01974 S101447_01974 2047730 2049211 - Cationic amino acid transporter 2%2C vacuolar Amino-acid transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Vacuole%3B Permease involved in the transport of the cationic amino acids%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2. A. 3. 3) family gene gene1973 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01974 S101447_01975 S101447_01975 glyA glyA 2049391 2050683 + Glycine hydroxymethyltransferase Amino-acid biosynthesis%3B Cytoplasm%3B One-carbon metabolism%3B Pyridoxal phosphate%3B Transferase%3B Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines%2C thymidylate%2C methionine%2C and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids%2C producing glycine and aldehydes%2C via a retro-aldol mechanism%3B Belongs to the SHMT family%3B KEGG: apt:APA01_19360 glycine hydroxymethyltransferase gene gene1974 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01975 S101447_01976 S101447_01976 S101447_01976 2050729 2051781 - hypothetical protein gene gene1975 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01976 S101447_01977 S101447_01977 S101447_01977 2051946 2053154 + hypothetical protein gene gene1976 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01977 S101447_01978 S101447_01978 S101447_01978 2053170 2054279 + hypothetical protein gene gene1977 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01978 S101447_01979 S101447_01979 S101447_01979 2054230 2055432 - RNA helicase ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Nucleus%3B Ribosome biogenesis%3B RNA-binding%3B rRNA processing%3B ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs%3B Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: apk:APA386B_841 ATP-dependent RNA helicase RhlE gene gene1978 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01979 S101447_01980 S101447_01980 S101447_01980 2055562 2056593 + Mitochondrial fission protein ELM1 Membrane%3B Mitochondrion%3B Mitochondrion outer membrane%3B Plant-specific factor involved in mitochondria fission. Is required for the correct localization of DRP3A from the cytosol to mitochondrial fission sites. Does not seem to be required for peroxisomal division gene gene1979 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01980 S101447_01981 S101447_01981 S101447_01981 2056617 2056811 - hypothetical protein gene gene1980 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01981 S101447_01982 S101447_01982 serB serB 2056848 2057738 - Phosphoserine phosphatase Amino-acid biosynthesis%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Serine biosynthesis%3B Belongs to the SerB family%3B KEGG: apt:APA01_19290 phosphoserine phosphatase gene gene1981 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01982 S101447_01983 S101447_01983 miaA miaA 2057769 2058782 + tRNA dimethylallyltransferase ATP-binding%3B Magnesium%3B Nucleotide-binding%3B Transferase%3B tRNA processing%3B Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine%2C leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)%3B Belongs to the IPP transferase family%3B KEGG: apt:APA01_19280 tRNA dimethylallyltransferase gene gene1982 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01983 S101447_01984 S101447_01984 S101447_01984 2058797 2060647 + Acetolactate synthase Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B FAD%3B Flavoprotein%3B Magnesium%3B Metal-binding%3B Thiamine pyrophosphate%3B Transferase%3B Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine%2C isoleucine%2C and valine. Also involved in condensing pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate (By similarity)%3B Belongs to the TPP enzyme family%3B KEGG: apt:APA01_19270 acetolactate synthase I/II/III large subunit gene gene1983 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01984 S101447_01985 S101447_01985 ilvH ilvH 2060714 2061232 + Acetolactate synthase Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Transferase%3B Belongs to the acetolactate synthase small subunit family%3B Contains 1 ACT domain%3B KEGG: apt:APA01_19260 acetolactate synthase I/III small subunit gene gene1984 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01985 S101447_01986 S101447_01986 ilvC ilvC 2061286 2062311 + Ketol-acid reductoisomerase (NADP(+)) Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B NADP%3B Oxidoreductase%3B Belongs to the ketol-acid reductoisomerase family%3B KEGG: palk:PSAKL28_07650 ketol-acid reductoisomerase gene gene1985 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01986 S101447_01987 S101447_01987 S101447_01987 2062395 2063390 - Copper resistance protein Cell outer membrane%3B Copper%3B Membrane%3B Plasmid%3B Signal. gene gene1986 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01987 S101447_01988 S101447_01988 S101447_01988 2063387 2065102 - Laccase Copper%3B Metal-binding%3B Oxidoreductase%3B Periplasm%3B Repeat%3B Signal%3B Could be involved in copper resistance. May have oxidase activity (By similarity)%3B Belongs to the multicopper oxidase family. CopA subfamily%3B KEGG: aly:ARALYDRAFT_486975 laccase gene gene1987 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01988 S101447_01989 S101447_01989 S101447_01989 2065197 2065580 + hypothetical protein gene gene1988 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01989 S101447_01990 S101447_01990 copA copA 2065726 2068098 + Cu(+) exporting ATPase ATP-binding%3B Cell membrane%3B Copper%3B Copper transport%3B Hydrolase%3B Ion transport%3B Magnesium%3B Membrane%3B Metal-binding%3B Nucleotide-binding%3B Phosphoprotein%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in copper export%3B Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily%3B Contains 2 HMA domains%3B KEGG: gox:GOX0662 Cu+-exporting ATPase gene gene1989 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01990 S101447_01991 S101447_01991 S101447_01991 2068104 2069408 - hypothetical protein gene gene1990 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01991 S101447_01992 S101447_01992 pncA pncA 2069442 2070071 - Nicotinamidase Cytoplasm%3B Hydrolase%3B Metal-binding%3B Nucleus%3B Peroxisome%3B Pyridine nucleotide biosynthesis%3B Zinc%3B Catalyzes the deamidation of nicotinamide%2C an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide%2C an inhibitor of SIR2%2C during times of stress. Acts also on nicotinyl hydroxamate%3B Belongs to the PncA family%3B KEGG: apt:APA01_19190 nicotinamidase/pyrazinamidase%3B Nicotinamidase gene gene1991 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01992 S101447_01993 S101447_01993 S101447_01993 2070084 2071412 - Glutamate--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: kci:CKCE_0469 glutamyl-tRNA synthetase gene gene1992 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01993 S101447_01994 S101447_01994 S101447_01994 2071469 2071888 - hypothetical protein gene gene1993 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01994 S101447_01995 S101447_01995 pncB pncB 2071885 2073084 - Nicotinate phosphoribosyltransferase KEGG: apt:APA01_19160 nicotinate phosphoribosyltransferase gene gene1994 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01995 S101447_01996 S101447_01996 aroF aroF 2073213 2074592 - 3-deoxy-7-phosphoheptulonate synthase Amino-acid biosynthesis%3B Aromatic amino acid biosynthesis%3B Transferase%3B Belongs to the class-II DAHP synthase family%3B KEGG: apt:APA01_19150 3-deoxy-7-phosphoheptulonate synthase gene gene1995 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01996 S101447_01997 S101447_01997 S101447_01997 2074884 2075288 + hypothetical protein gene gene1996 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01997 S101447_01998 S101447_01998 thyA thyA 2075285 2075884 - Thymidylate synthase Belongs to the IMPACT family%3B KEGG: psp:PSPPH_4623 thymidylate synthase gene gene1997 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01998 S101447_01999 S101447_01999 S101447_01999 2076132 2076515 + hypothetical protein gene gene1998 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_01999 S101447_02000 S101447_02000 S101447_02000 2076567 2077391 - Putative pyruvate%2C phosphate dikinase regulatory protein Kinase%3B Nucleotide-binding%3B Serine/threonine-protein kinase%3B Transferase%3B Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate%2C phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation%3B Belongs to the pyruvate%2C phosphate/water dikinase regulatory protein family. PDRP subfamily gene gene1999 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02000 S101447_02001 S101447_02001 S101447_02001 2077442 2080063 - Pyruvate%2C phosphate dikinase Acetylation%3B Alternative promoter usage%3B ATP-binding%3B Chloroplast%3B Cytoplasm%3B Kinase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Phosphoprotein%3B Photosynthesis%3B Plastid%3B Transferase%3B Transit peptide%3B Formation of phosphoenolpyruvate%2C which is the primary acceptor of CO(2) in C4 and some Crassulacean acid metabolism plants%3B Belongs to the PEP-utilizing enzyme family%3B KEGG: ftu:FTT_0250 pyruvate%2C orthophosphate dikinase gene gene2000 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02001 S101447_02002 S101447_02002 ligA ligA 2080341 2082428 - DNA ligase (NAD(+)) DNA damage%3B DNA repair%3B DNA replication%3B Ligase%3B Magnesium%3B Manganese%3B Metal-binding%3B NAD%3B Zinc%3B DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA%3B Belongs to the NAD-dependent DNA ligase family. LigA subfamily%3B Contains 1 BRCT domain%3B KEGG: apk:APA386B_813 DNA ligase (NAD+) gene gene2001 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02002 S101447_02003 S101447_02003 S101447_02003 2082421 2084154 - DNA repair protein RecN ATP-binding%3B DNA damage%3B DNA repair%3B Nucleotide-binding%3B May be involved in recombinational repair of damaged DNA%3B Belongs to the RecN family gene gene2002 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02003 S101447_02004 S101447_02004 S101447_02004 2084312 2085349 - Outer membrane protein assembly factor BamD Cell outer membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Repeat%3B Signal%3B TPR repeat%3B Part of the outer membrane protein assembly complex%2C which is involved in assembly and insertion of beta-barrel proteins into the outer membrane%3B Belongs to the BamD family%3B Contains 3 TPR repeats gene gene2003 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02004 S101447_02005 S101447_02005 lpxC lpxC 2085446 2086426 - UDP-3-O-acyl-N-acetylglucosamine deacetylase Hydrolase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the LpxC family%3B KEGG: apt:APA01_19060 UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase gene gene2004 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02005 S101447_02006 S101447_02006 S101447_02006 2086580 2088097 - Mitochondrial division protein fszB GTP-binding%3B Mitochondrion%3B Nucleotide-binding%3B Probably involved in mitochondrion division process. Binds to and hydrolyzes GTP (By similarity)%3B Belongs to the FtsZ family gene gene2005 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02006 S101447_02007 S101447_02007 S101447_02007 2088184 2089620 - Cell division protein FtsA Cell cycle%3B Cell division%3B Cell inner membrane%3B Cell membrane%3B Cell shape%3B Membrane%3B Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring%3B Belongs to the FtsA/MreB family gene gene2006 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02007 S101447_02008 S101447_02008 S101447_02008 2089613 2090575 - Cell division protein FtsQ Cell cycle%3B Cell division%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Essential cell division protein%3B Belongs to the FtsQ/DivIB family. FtsQ subfamily%3B Contains 1 POTRA domain gene gene2007 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02008 S101447_02009 S101447_02009 S101447_02009 2090572 2091510 - D-alanine--D-alanine ligase ATP-binding%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Ligase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nucleotide-binding%3B Peptidoglycan synthesis%3B Cell wall formation%3B Belongs to the D-alanine--D-alanine ligase family%3B Contains 1 ATP-grasp domain%3B KEGG: apt:APA01_19020 D-alanine-D-alanine ligase gene gene2008 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02009 S101447_02010 S101447_02010 murB murB 2091507 2092451 - UDP-N-acetylmuramate dehydrogenase Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B FAD%3B Flavoprotein%3B NADP%3B Oxidoreductase%3B Peptidoglycan synthesis%3B Cell wall formation%3B Belongs to the MurB family%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: apt:APA01_19010 UDP-N-acetylmuramate dehydrogenase gene gene2009 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02010 S101447_02011 S101447_02011 murC murC 2092448 2093881 - UDP-N-acetylmuramate--L-alanine ligase ATP-binding%3B Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Peptidoglycan synthesis%3B Cell wall formation%3B Belongs to the MurCDEF family%3B KEGG: gbe:GbCGDNIH1_0428 UDP-N-acetylmuramate--alanine ligase gene gene2010 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02011 S101447_02012 S101447_02012 murG murG 2093878 2095026 - Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase Cell cycle%3B Cell division%3B Cell inner membrane%3B Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Glycosyltransferase%3B Membrane%3B Peptidoglycan synthesis%3B Transferase%3B Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)%3B Belongs to the glycosyltransferase 28 family. MurG subfamily%3B KEGG: apt:APA01_18990 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase gene gene2011 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02012 S101447_02013 S101447_02013 S101447_02013 2095023 2096186 - Putative lipid II flippase FtsW Cell cycle%3B Cell division%3B Cell inner membrane%3B Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Membrane%3B Peptidoglycan synthesis%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Essential cell division protein. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane (By similarity)%3B Belongs to the SEDS family. FtsW subfamily gene gene2012 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02013 S101447_02014 S101447_02014 murD murD 2096194 2097609 - UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase ATP-binding%3B Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Peptidoglycan synthesis%3B Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)%3B Belongs to the MurCDEF family%3B KEGG: apt:APA01_18970 UDP-N-acetylmuramoylalanine--D-glutamate ligase gene gene2013 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02014 S101447_02015 S101447_02015 mraY mraY 2097606 2098700 - Phospho-N-acetylmuramoyl-pentapeptide-transferase Cell cycle%3B Cell division%3B Cell inner membrane%3B Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Membrane%3B Peptidoglycan synthesis%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan%3B Belongs to the glycosyltransferase 4 family. MraY subfamily%3B KEGG: apt:APA01_18960 phospho-N-acetylmuramoyl-pentapeptide-transferase gene gene2014 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02015 S101447_02016 S101447_02016 murF murF 2098700 2100085 - UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase ATP-binding%3B Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Ligase%3B Magnesium%3B Nucleotide-binding%3B Peptidoglycan synthesis%3B Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan%3B Belongs to the MurCDEF family. MurE subfamily%3B KEGG: apt:APA01_18950 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase gene gene2015 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02016 S101447_02017 S101447_02017 murE murE 2100082 2101551 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase ATP-binding%3B Cell cycle%3B Cell division%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Ligase%3B Magnesium%3B Nucleotide-binding%3B Peptidoglycan synthesis%3B Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan%3B Belongs to the MurCDEF family. MurE subfamily%3B KEGG: apt:APA01_18940 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase gene gene2016 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02017 S101447_02018 S101447_02018 S101447_02018 2101548 2103566 - Peptidoglycan synthase ftsI like protein Cell cycle%3B Cell division%3B Cell shape%3B Chloroplast%3B Glycosyltransferase%3B Membrane%3B Peptidoglycan synthesis%3B Plastid%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates (Potential)%3B Belongs to the transpeptidase family gene gene2017 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02018 S101447_02019 S101447_02019 S101447_02019 2103599 2104588 - hypothetical protein gene gene2018 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02019 S101447_02020 S101447_02020 mraW mraW 2104593 2105600 - 16S rRNA (cytosine(1402)-N(4))-methyltransferase Cytoplasm%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA%3B Belongs to the methyltransferase superfamily. RsmH family%3B KEGG: apt:APA01_18910 16S rRNA (cytosine1402-N4)-methyltransferase gene gene2019 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02020 S101447_02021 S101447_02021 S101447_02021 2105597 2106235 - Transcriptional regulator MraZ Cytoplasm%3B DNA-binding%3B Repeat%3B Transcription%3B Transcription regulation%3B Belongs to the MraZ family%3B Contains 2 SpoVT-AbrB domains gene gene2020 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02021 S101447_02022 S101447_02022 S101447_02022 2106454 2106798 + hypothetical protein gene gene2021 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02022 S101447_02023 S101447_02023 S101447_02023 2106865 2107917 + Putative acetyl-hydrolase LipR Hydrolase%3B Signal%3B Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH%3B Belongs to the 'GDXG' lipolytic enzyme family%3B KEGG: apt:APA01_18890 acetyl esterase%3B Carboxylic ester hydrolases gene gene2022 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02023 S101447_02024 S101447_02024 S101447_02024 2107933 2108379 - hypothetical protein gene gene2023 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02024 S101447_02025 S101447_02025 g6pD g6pD 2108376 2109848 - Glucose-6-phosphate dehydrogenase (NADP(+)) Carbohydrate metabolism%3B Glucose metabolism%3B NADP%3B Oxidoreductase%3B Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone%3B Belongs to the glucose-6-phosphate dehydrogenase family%3B KEGG: apt:APA01_18870 glucose-6-phosphate 1-dehydrogenase gene gene2024 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02025 S101447_02026 S101447_02026 S101447_02026 2110106 2110378 + UPF0335 protein Plasmid%3B Belongs to the UPF0335 family gene gene2025 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02026 S101447_02027 S101447_02027 S101447_02027 2110402 2111055 + hypothetical protein gene gene2026 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02027 S101447_02028 S101447_02028 proB proB 2111061 2112188 - Glutamate 5-kinase Amino-acid biosynthesis%3B ATP-binding%3B Cytoplasm%3B Kinase%3B Nucleotide-binding%3B Proline biosynthesis%3B Transferase%3B Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate%3B Belongs to the glutamate 5-kinase family%3B Contains 1 PUA domain%3B KEGG: apt:APA01_18840 glutamate 5-kinase gene gene2027 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02028 S101447_02029 S101447_02029 S101447_02029 2112243 2113262 - GTPase Obg Cytoplasm%3B GTP-binding%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B An essential GTPase which binds GTP%2C GDP and possibly (p)ppGpp with moderate affinity%2C with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle%2C stress response%2C ribosome biogenesis and in those bacteria that undergo differentiation%2C in morphogenesis control%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family%3B Contains 1 OBG-type G (guanine nucleotide-binding) domain gene gene2028 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02029 S101447_02030 S101447_02030 S101447_02030 2113371 2113640 - 50S ribosomal protein L27 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein L27P family gene gene2029 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02030 S101447_02031 S101447_02031 S101447_02031 2113689 2114003 - 50S ribosomal protein L21 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B This protein binds to 23S rRNA in the presence of protein L20%3B Belongs to the ribosomal protein L21P family gene gene2030 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02031 S101447_02032 S101447_02032 S101447_02032 2114224 2114313 + tRNA-Ser tRNA gene2031 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02032 S101447_02033 S101447_02033 S101447_02033 2114857 2118561 + AIDA-I autotransporter Autocatalytic cleavage%3B Cell adhesion%3B Cell outer membrane%3B Glycoprotein%3B Membrane%3B Periplasm%3B Plasmid%3B Secreted%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Virulence%3B Potent bacterial adhesin that mediates bacterial attachment to a broad variety of human and other mammalian cells. AIDA possesses additional virulence properties%2C as it is capable of mediating bacterial autoaggregation via intercellular self- recognition and it is a highly efficient initiator of biofilm formation%3B Contains 1 autotransporter (TC 1. B. 12) domain gene gene2032 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02033 S101447_02034 S101447_02034 S101447_02034 2118831 2119754 + Arylacetamide deacetylase-like Alternative splicing%3B Hydrolase%3B Polymorphism%3B Belongs to the 'GDXG' lipolytic enzyme family%3B KEGG: mxa:MXAN_0700 acetyl esterase%3B Carboxylic ester hydrolases gene gene2033 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02034 S101447_02035 S101447_02035 S101447_02035 2119844 2120179 + hypothetical protein gene gene2034 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02035 S101447_02036 S101447_02036 S101447_02036 2120688 2121392 - hypothetical protein gene gene2035 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02036 S101447_02037 S101447_02037 S101447_02037 2121495 2121737 - hypothetical protein gene gene2036 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02037 S101447_02038 S101447_02038 S101447_02038 2121961 2123319 + Adenine permease AdeP Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B High-affinity transporter for adenine%3B Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2. A. 1. 40) subfamily gene gene2037 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02038 S101447_02039 S101447_02039 S101447_02039 2123367 2124683 - hypothetical protein gene gene2038 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02039 S101447_02040 S101447_02040 S101447_02040 2124812 2125399 - hypothetical protein gene gene2039 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02040 S101447_02041 S101447_02041 S101447_02041 2125442 2125993 - NAD(P)H dehydrogenase (quinone) Flavoprotein%3B FMN%3B NAD%3B NADP%3B Nucleotide-binding%3B Oxidoreductase%3B Belongs to the WrbA family%3B Contains 1 flavodoxin-like domain%3B KEGG: lfa:LFA_3541 NAD(P)H dehydrogenase (quinone) gene gene2040 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02041 S101447_02042 S101447_02042 rip1 rip1 2126177 2126815 - Quinol--cytochrome-c reductase 2Fe-2S%3B Cell membrane%3B Disulfide bond%3B Electron transport%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex)%2C which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. Contains 1 Rieske domain%3B KEGG: apt:APA01_18610 ubiquinol-cytochrome c reductase iron-sulfur subunit gene gene2041 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02042 S101447_02043 S101447_02043 S101447_02043 2126834 2127607 - Cytochrome c1-1%2C heme protein%2C mitochondrial Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Mitochondrion%3B Mitochondrion inner membrane%3B Respiratory chain%3B Transit peptide%3B Transmembrane%3B Transmembrane helix%3B Transport%3B This is the heme-containing component of the cytochrome b-c1 complex%2C which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain. Belongs to the cytochrome c family%3B Contains 1 cytochrome c domain gene gene2042 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02043 S101447_02044 S101447_02044 S101447_02044 2127607 2128848 - Cytochrome b/c1 Cell inner membrane%3B Cell membrane%3B Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex)%2C which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. c1 functions as an electron donor to cytochrome c. Belongs to the cytochrome b family%3B Contains 1 cytochrome c domain gene gene2043 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02044 S101447_02045 S101447_02045 ribD ribD 2129535 2130554 + Diaminohydroxyphosphoribosylaminopyrimidine deaminase Hydrolase%3B Metal-binding%3B Multifunctional enzyme%3B NADP%3B Oxidoreductase%3B Riboflavin biosynthesis%3B Zinc%3B Converts 2%2C5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2%2C4(1h%2C3h)- pyrimidinedione 5'-phosphate. In the N-terminal sectio%3B belongs to the cytidine and deoxycytidylate deaminase family%3B In the C-terminal sectio%3B belongs to the HTP reductase family%3B Contains 1 CMP/dCMP-type deaminase domain%3B KEGG: apt:APA01_18580 diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase gene gene2044 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02045 S101447_02046 S101447_02046 ribE ribE 2130536 2131138 + Riboflavin synthase Repeat%3B Riboflavin biosynthesis%3B Transferase%3B Catalyzes the dismutation of two molecules of 6%2C7- dimethyl-8-ribityllumazine%2C resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil%3B Contains 2 lumazine-binding repeats%3B KEGG: apk:APA386B_772 riboflavin synthase gene gene2045 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02046 S101447_02047 S101447_02047 S101447_02047 2131123 2132466 + 3%2C4-dihydroxy-2-butanone-4-phosphate synthase Lyase%3B Magnesium%3B Manganese%3B Metal-binding%3B Riboflavin biosynthesis%3B Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3%2C4-dihydroxy-2-butanone 4-phosphate%3B Belongs to the DHBP synthase family%3B KEGG: apk:APA386B_771 3%2C4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II gene gene2046 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02047 S101447_02048 S101447_02048 ribH ribH 2132504 2132989 + 6%2C7-dimethyl-8-ribityllumazine synthase Riboflavin biosynthesis%3B Transferase%3B Catalyzes the formation of 6%2C7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3%2C4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin%3B Belongs to the DMRL synthase family%3B KEGG: apt:APA01_18550 6%2C7-dimethyl-8-ribityllumazine synthase gene gene2047 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02048 S101447_02049 S101447_02049 S101447_02049 2133060 2134070 + hypothetical protein gene gene2048 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02049 S101447_02050 S101447_02050 S101447_02050 2134185 2136779 + hypothetical protein gene gene2049 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02050 S101447_02051 S101447_02051 S101447_02051 2136882 2138141 - Sulfide:quinone oxidoreductase%2C mitochondrial Acetylation%3B FAD%3B Flavoprotein%3B Mitochondrion%3B Oxidoreductase%3B Phosphoprotein%3B Polymorphism%3B Quinone%3B Transit peptide%3B Catalyzes the oxidation of hydrogen sulfide with the help of a quinone%2C such as ubiquinone%2C giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron accepto%3B can use sulfite%2C sulfide or cyanide (in vitro)%3B Belongs to the SQRD family%3B KEGG: apt:APA01_18520 sulfide:quinone oxidoreductase%3B With a quinone or similar compound as acceptor gene gene2050 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02051 S101447_02052 S101447_02052 S101447_02052 2138243 2138479 - hypothetical protein gene gene2051 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02052 S101447_02053 S101447_02053 S101447_02053 2138581 2139345 - hypothetical protein gene gene2052 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02053 S101447_02054 S101447_02054 S101447_02054 2139387 2140349 - uncharacterized protein Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene2053 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02054 S101447_02055 S101447_02055 S101447_02055 2140365 2140565 - hypothetical protein gene gene2054 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02055 S101447_02056 S101447_02056 S101447_02056 2140567 2142651 - putative transporter Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the aromatic acid exporter ArAE (TC 2. A. 85) family gene gene2055 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02056 S101447_02057 S101447_02057 S101447_02057 2142887 2143012 + hypothetical protein gene gene2056 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02057 S101447_02058 S101447_02058 S101447_02058 2142966 2144114 + hypothetical protein gene gene2057 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02058 S101447_02059 S101447_02059 S101447_02059 2144111 2146816 + putative abhydrolase domain-containing protein Acetylation%3B Coiled coil%3B Hydrolase%3B Belongs to the AB hydrolase superfamily gene gene2058 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02059 S101447_02060 S101447_02060 S101447_02060 2146800 2148266 - Porin Cell outer membrane%3B Ion transport%3B Membrane%3B Porin%3B Signal%3B Sugar transport%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Substrate-selective channel for a variety of different sugars. Could potentially facilitate the diffusion of diverse compounds%2C dependent on the presence of a hydroxyl group%2C but is presumably restricted to carbohydrates. Involved in the transport of glucose%2C mannitol%2C fructose and glycerol (sugars able to support the growth of P. aeruginosa). Facilitates glucose diffusion across the outer membrane. Belongs to the OprB family gene gene2059 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02060 S101447_02061 S101447_02061 S101447_02061 2148483 2149037 + Molybdenum cofactor biosynthesis protein GTP-binding%3B Molybdenum cofactor biosynthesis%3B Nucleotide-binding%3B May be involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT%2C but has no MPT adenylyl transferase activity%3B Belongs to the MoaB/Mog family gene gene2060 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02061 S101447_02062 S101447_02062 pfpI pfpI 2149030 2149608 + Protein DJ-1 like protein Lyase%3B Oxidation%3B Repeat%3B Stress response%3B Possesses glyoxalase I activity. Catalyzes the conversion of hemimercaptal%2C formed from methylglyoxal and glutathione%2C to S-lactoylglutathione. May be involved in oxidative stress response%3B Belongs to the peptidase C56 family%3B Contains 2 PfpI endopeptidase domains%3B KEGG: apt:APA01_18420 protease I%3B Glycosylases gene gene2061 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02062 S101447_02063 S101447_02063 gch1 gch1 2149666 2150277 - GTP cyclohydrolase I GTP-binding%3B Hydrolase%3B Metal-binding%3B Nucleotide-binding%3B One-carbon metabolism%3B Zinc%3B Belongs to the GTP cyclohydrolase I family%3B KEGG: apt:APA01_18410 GTP cyclohydrolase I gene gene2062 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02063 S101447_02064 S101447_02064 S101447_02064 2150317 2150787 - Protein ApaG Contains 1 apaG domain gene gene2063 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02064 S101447_02065 S101447_02065 metZ metZ 2150907 2152115 - O-succinylhomoserine sulfhydrylase Amino-acid biosynthesis%3B Methionine biosynthesis%3B Pyridoxal phosphate%3B Transferase%3B Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide%3B Belongs to the trans-sulfuration enzymes family%3B KEGG: apt:APA01_18390 O-succinylhomoserine sulfhydrylase%3B Transferring alkyl or aryl groups%2C other than methyl groups gene gene2064 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02065 S101447_02066 S101447_02066 algA algA 2152436 2153899 + Mannose-1-phosphate guanylyltransferase Exopolysaccharide synthesis%3B GTP-binding%3B Isomerase%3B Lipopolysaccharide biosynthesis%3B Multifunctional enzyme%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase%3B Involved in xanthan production. Belongs to the mannose-6-phosphate isomerase type 2 family%3B KEGG: apt:APA01_18380 mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase gene gene2065 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02066 S101447_02067 S101447_02067 S101447_02067 2153945 2154937 - 8-oxo-dGTP diphosphatase Hydrolase%3B Magnesium%3B Manganese%3B Hydrolase with a preference for pyrimidine substrates. Has high activity with 5-methyl-dCTP%2C and much lower activity with CTP%2C dCTP%2C 5-hydroxy-dCTP%2C 2-hydroxy-dATP and 8-hydroxy-dGTP%3B Belongs to the Nudix hydrolase family%3B Contains 1 nudix hydrolase domain%3B KEGG: apk:APA386B_751 8-oxo-dGTP diphosphatase gene gene2066 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02067 S101447_02068 S101447_02068 S101447_02068 2154930 2156048 - Chlorophyllide a oxygenase%2C chloroplastic 2Fe-2S%3B Alternative splicing%3B Chlorophyll biosynthesis%3B Chloroplast%3B Coiled coil%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B NADP%3B Oxidoreductase%3B Plastid%3B Thylakoid%3B Transit peptide%3B Catalyzes a two-step oxygenase reaction involved in the synthesis of chlorophyll b. Acts specifically on the non- esterified chlorophyllide a and not on chlorophyll a%3B Contains 1 Rieske domain%3B KEGG: bxe:Bxe_B0203 null%3B Acting on paired donors%2C with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O(2) gene gene2067 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02068 S101447_02069 S101447_02069 S101447_02069 2156164 2157033 - hypothetical protein gene gene2068 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02069 S101447_02070 S101447_02070 S101447_02070 2157183 2157545 + UPF0092 membrane protein YrbF Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0092 family gene gene2069 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02070 S101447_02071 S101447_02071 priA priA 2157573 2159843 - Primosomal protein N' ATP-binding%3B DNA replication%3B DNA-binding%3B Helicase%3B Hydrolase%3B Metal-binding%3B Nucleotide-binding%3B Primosome%3B Zinc%3B Zinc-finger%3B Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex%2C via its helicase activity%2C and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA%3B Belongs to the helicase family. PriA subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: apt:APA01_18330 primosomal protein N' (replication factor Y) (superfamily II helicase)%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene2070 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02071 S101447_02072 S101447_02072 S101447_02072 2159927 2160874 + Tyrosine recombinase XerC Cell cycle%3B Cell division%3B Chromosome partition%3B Cytoplasm%3B DNA integration%3B DNA recombination%3B DNA-binding%3B Site-specific tyrosine recombinase%2C which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids%3B Belongs to the 'phage' integrase family. XerC subfamily gene gene2071 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02072 S101447_02073 S101447_02073 S101447_02073 2160906 2161868 + Prolyl aminopeptidase Aminopeptidase%3B Cytoplasm%3B Hydrolase%3B Protease%3B Specifically catalyzes the removal of N-terminal proline residues from peptides%3B Belongs to the peptidase S33 family%3B KEGG: apt:APA01_18310 proline iminopeptidase gene gene2072 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02073 S101447_02074 S101447_02074 S101447_02074 2161865 2162800 + hypothetical protein gene gene2073 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02074 S101447_02075 S101447_02075 S101447_02075 2162850 2163314 - hypothetical protein gene gene2074 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02075 S101447_02076 S101447_02076 S101447_02076 2163510 2164883 - Ammonia channel Ammonia transport%3B Cell membrane%3B Membrane%3B Signal%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the uptake of ammonia. Belongs to the ammonia transporter channel (TC 1. A. 11. 2) family gene gene2075 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02076 S101447_02077 S101447_02077 S101447_02077 2165372 2167105 + hypothetical protein gene gene2076 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02077 S101447_02078 S101447_02078 S101447_02078 2167366 2168754 + hypothetical protein gene gene2077 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02078 S101447_02079 S101447_02079 S101447_02079 2169035 2171020 + hypothetical protein gene gene2078 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02079 S101447_02080 S101447_02080 S101447_02080 2171094 2172464 - hypothetical protein gene gene2079 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02080 S101447_02081 S101447_02081 S101447_02081 2172780 2174339 + hypothetical protein gene gene2080 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02081 S101447_02082 S101447_02082 S101447_02082 2174428 2176659 - hypothetical protein gene gene2081 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02082 S101447_02083 S101447_02083 S101447_02083 2176703 2178901 - hypothetical protein gene gene2082 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02083 S101447_02084 S101447_02084 S101447_02084 2179073 2180713 - 60 kDa chaperonin ATP-binding%3B Chaperone%3B Cytoplasm%3B Nucleotide-binding%3B Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions%3B Belongs to the chaperonin (HSP60) family gene gene2083 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02084 S101447_02085 S101447_02085 S101447_02085 2180768 2181061 - 10 kDa chaperonin Chaperone%3B Cytoplasm%3B Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter%3B Belongs to the GroES chaperonin family gene gene2084 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02085 S101447_02086 S101447_02086 S101447_02086 2181273 2181941 + Carboxymethylenebutenolidase Hydrolase%3B Belongs to the dienelactone hydrolase family%3B KEGG: apt:APA01_17850 carboxymethylenebutenolidase gene gene2085 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02086 S101447_02087 S101447_02087 S101447_02087 2182085 2182288 + Cold shock-like protein 7.0 Activator%3B Cytoplasm%3B DNA-binding%3B Stress response%3B Transcription%3B Transcription regulation%3B Contains 1 CSD (cold-shock) domain gene gene2086 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02087 S101447_02088 S101447_02088 dinG dinG 2182307 2185264 - DNA helicase ATP-binding%3B DNA damage%3B DNA recombination%3B DNA repair%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Probable helicase involved in DNA repair and perhaps also replication%3B Belongs to the helicase family. DinG subfamily%3B Contains 1 exonuclease domain%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: apt:APA01_17830 ATP-dependent DNA helicase DinG gene gene2087 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02088 S101447_02089 S101447_02089 S101447_02089 2185397 2186233 - Inositol-phosphate phosphatase Hydrolase%3B Magnesium%3B Metal-binding%3B Belongs to the inositol monophosphatase family%3B KEGG: apk:APA386B_722 myo-inositol-1(or 4)-monophosphatase gene gene2088 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02089 S101447_02090 S101447_02090 S101447_02090 2186273 2186839 - Elongation factor Cytoplasm%3B Elongation factor%3B Protein biosynthesis%3B Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA%2C thus increasing their reactivity as acceptors for peptidyl transferase%3B Belongs to the elongation factor P family gene gene2089 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02090 S101447_02091 S101447_02091 S101447_02091 2186999 2187088 + tRNA-Ser tRNA gene2090 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02091 S101447_02092 S101447_02092 S101447_02092 2187637 2188212 - putative membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the DedA family gene gene2091 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02092 S101447_02093 S101447_02093 S101447_02093 2188568 2189818 + uncharacterized protein FAD%3B Flavoprotein%3B Monooxygenase%3B Oxidoreductase%3B Belongs to the UbiH/COQ6 family%3B KEGG: apt:APA01_17730 2-octaprenyl-6-methoxyphenol hydroxylase%3B With NADH or NADPH as one donor%2C and incorporation of one atom of oxygen gene gene2092 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02093 S101447_02094 S101447_02094 cysE cysE 2189822 2190691 + Serine O-acetyltransferase Acyltransferase%3B Amino-acid biosynthesis%3B Cysteine biosynthesis%3B Cytoplasm%3B Repeat%3B Transferase%3B Belongs to the transferase hexapeptide repeat family%3B KEGG: apt:APA01_17720 serine O-acetyltransferase gene gene2093 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02094 S101447_02095 S101447_02095 S101447_02095 2190776 2191114 - Nitrogen regulatory protein P-II Nucleotide-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B In nitrogen-limiting conditions%2C when the ratio of Gln to 2-ketoglutarate decreases%2C P-II is uridylylated to P-II-UMP. P- II-UMP allows the deadenylation of glutamine synthetase (GS)%2C thus activating the enzyme. Conversely%2C in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate%2C the transcriptional activator of glnA. When P-II is uridylylated to P- II-UMP%2C these events are reversed (By similarity)%3B Belongs to the P(II) protein family gene gene2094 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02095 S101447_02096 S101447_02096 ugdH ugdH 2191356 2192735 + UDP-glucose 6-dehydrogenase Cell wall biogenesis/degradation%3B Cytoplasm%3B NAD%3B Oxidoreductase%3B Phosphoprotein%3B Stress response%3B Catalyzes the conversion of UDP-glucose into UDP- glucuronate%2C one of the precursors of teichuronic acid. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family%3B KEGG: apt:APA01_17690 UDPglucose 6-dehydrogenase gene gene2095 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02096 S101447_02097 S101447_02097 S101447_02097 2192874 2193119 + hypothetical protein gene gene2096 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02097 S101447_02098 S101447_02098 S101447_02098 2193218 2193469 - hypothetical protein gene gene2097 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02098 S101447_02099 S101447_02099 uprT uprT 2193509 2194159 - Uracil phosphoribosyltransferase Allosteric enzyme%3B Glycosyltransferase%3B GTP-binding%3B Magnesium%3B Nucleotide-binding%3B Transferase%3B Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate%3B Belongs to the UPRTase family%3B KEGG: apt:APA01_17660 uracil phosphoribosyltransferase gene gene2098 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02099 S101447_02100 S101447_02100 S101447_02100 2194262 2195647 + hypothetical protein gene gene2099 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02100 S101447_02101 S101447_02101 S101447_02101 2195707 2196192 + Xanthine phosphoribosyltransferase Cell inner membrane%3B Cell membrane%3B Glycosyltransferase%3B Magnesium%3B Membrane%3B Metal-binding%3B Purine salvage%3B Transferase%3B Acts on guanine%2C xanthine and to a lesser extent hypoxanthine%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily%3B KEGG: apt:APA01_17640 xanthine phosphoribosyltransferase gene gene2100 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02101 S101447_02102 S101447_02102 S101447_02102 2196251 2196327 + tRNA-Pro tRNA gene2101 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02102 S101447_02103 S101447_02103 S101447_02103 2196351 2196656 + hypothetical protein gene gene2102 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02103 S101447_02104 S101447_02104 S101447_02104 2196693 2196769 + tRNA-Arg tRNA gene2103 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02104 S101447_02105 S101447_02105 S101447_02105 2196803 2198623 + Galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1%2C5/1%2C6-galactofuranosyltransferase KEGG: rmu:RMDY18_06860 galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1%2C5/1%2C6-galactofuranosyltransferase gene gene2104 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02105 S101447_02106 S101447_02106 S101447_02106 2198771 2199922 + UDP-galactopyranose mutase FAD%3B Flavoprotein%3B Isomerase%3B Lipopolysaccharide biosynthesis%3B Signal%3B Involved in the biosynthesis of the galactose-containing O-side-chain polysaccharide backbone structure of D-galactan I which is a key component of lipopolysaccharide (LPS). Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF) which is the biosynthetic precursor of galactofuranosyl residues%3B Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family%3B KEGG: zmm:Zmob_0545 UDP-galactopyranose mutase gene gene2105 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02106 S101447_02107 S101447_02107 S101447_02107 2200078 2202252 + hypothetical protein gene gene2106 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02107 S101447_02108 S101447_02108 S101447_02108 2202330 2204156 - hypothetical protein gene gene2107 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02108 S101447_02109 S101447_02109 S101447_02109 2204435 2205403 + Dolichyl-phosphate beta-D-mannosyltransferase Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Glycosyltransferase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Lipopolysaccharide biosynthesis%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides%3B Belongs to the glycosyltransferase 2 family%3B KEGG: glp:Glo7428_0278 dolichol-phosphate mannosyltransferase gene gene2108 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02109 S101447_02110 S101447_02110 S101447_02110 2205471 2206625 + 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Isoprene biosynthesis%3B Lyase%3B Metal-binding%3B Multifunctional enzyme%3B Nucleotidyltransferase%3B Transferase%3B Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD)%2C and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2%2C4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)%3B In the N-terminal sectio%3B belongs to the IspD family%3B In the C-terminal sectio%3B belongs to the IspF family%3B KEGG: gxy:GLX_24870 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase / 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase gene gene2109 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02110 S101447_02111 S101447_02111 dusB dusB 2206711 2207781 + putative tRNA-dihydrouridine synthase Flavoprotein%3B FMN%3B NADP%3B Oxidoreductase%3B RNA-binding%3B tRNA processing%3B tRNA-binding%3B Catalyzes the synthesis of 5%2C6-dihydrouridine (D)%2C a modified base found in the D-loop of most tRNAs%2C via the reduction of the C5-C6 double bond in target uridines%3B Belongs to the Dus family%3B KEGG: apk:APA386B_684 tRNA-dihydrouridine synthase B%3B Oxidoreductases gene gene2110 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02111 S101447_02112 S101447_02112 glnL glnL 2207778 2208887 + Histidine kinase ATP-binding%3B Kinase%3B Nitrogen fixation%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Two-component regulatory system%3B NtrB acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of NtrC. In nitrogen limitation NtrB activates NtrC by phosphorylating it%2C while in nitrogen excess NtrC is dephosphorylated and consequently inactivated by NtrB. Contains 1 histidine kinase domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: apt:APA01_17520 two-component system%2C NtrC family%2C nitrogen regulation sensor histidine kinase GlnL gene gene2111 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02112 S101447_02113 S101447_02113 S101447_02113 2208944 2210386 + Transcriptional regulatory protein PrrA Cytoplasm%3B DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system%3B Member of the two-component regulatory system PrrB/PrrA. Involved specifically in early intracellular multiplication of Mycobacterium (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2112 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02113 S101447_02114 S101447_02114 ntrY ntrY 2210396 2212660 + Histidine kinase ATP-binding%3B Cell membrane%3B Kinase%3B Membrane%3B Nitrogen fixation%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system%3B Member of the two-component regulatory system NtrY/NtrX involved in nitrogen level control. Probably activates NtrX by phosphorylation. Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: apt:APA01_17500 two-component system%2C NtrC family%2C nitrogen regulation sensor histidine kinase NtrY gene gene2113 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02114 S101447_02115 S101447_02115 S101447_02115 2212650 2214041 + Nitrogen assimilation regulatory protein NtrX Activator%3B ATP-binding%3B DNA-binding%3B Nitrogen fixation%3B Nucleotide-binding%3B Phosphoprotein%3B Repressor%3B Transcription%3B Transcription regulation%3B Two-component regulatory system%3B Member of the two-component regulatory system NtrY/NtrX involved in the activation of nitrogen assimilatory genes such as GlnA. NtrX is probably phosphorylated by NtrY and interacts with sigma-54. Contains 1 response regulatory domain%3B Contains 1 sigma-54 factor interaction domain gene gene2114 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02115 S101447_02116 S101447_02116 S101447_02116 2214118 2214402 + RNA-binding protein Hfq RNA-binding%3B Stress response%3B RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress%2C environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs%3B Belongs to the Hfq family gene gene2115 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02116 S101447_02117 S101447_02117 S101447_02117 2214383 2215702 + GTPase HflX Cytoplasm%3B GTP-binding%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family%3B Contains 1 Hflx-type G (guanine nucleotide-binding) domain gene gene2116 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02117 S101447_02118 S101447_02118 S101447_02118 2215762 2216394 - ADP-ribose diphosphatase Hydrolase%3B Magnesium%3B Manganese%3B Metal-binding%3B Probably mediates the hydrolysis of some nucleoside diphosphate derivatives%3B Belongs to the Nudix hydrolase family%3B Contains 1 nudix hydrolase domain%3B KEGG: bcl:ABC0282 ADP-ribose pyrophosphatase gene gene2117 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02118 S101447_02119 S101447_02119 S101447_02119 2216483 2219098 - Chaperone protein ClpB ATP-binding%3B Chaperone%3B Coiled coil%3B Cytoplasm%3B Nucleotide-binding%3B Repeat%3B Stress response%3B Part of a stress-induced multi-chaperone system%2C it is involved in the recovery of the cell from heat-induced damage%2C in cooperation with DnaK%2C DnaJ and GrpE. Acts before DnaK%2C in the processing of protein aggregates. Protein binding stimulates the ATPase activit%3B ATP hydrolysis unfolds the denatured protein aggregates%2C which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates%2C contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity)%3B Belongs to the ClpA/ClpB family gene gene2118 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02119 S101447_02120 S101447_02120 sod2 sod2 2219355 2219963 - Superoxide dismutase Iron%3B Metal-binding%3B Oxidoreductase%3B Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family%3B KEGG: mey:TM49_09935 superoxide dismutase%2C Fe-Mn family gene gene2119 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02120 S101447_02121 S101447_02121 S101447_02121 2220158 2221012 + 15-cis-phytoene synthase KEGG: apt:APA01_17430 phytoene synthase gene gene2120 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02121 S101447_02122 S101447_02122 S101447_02122 2220961 2221836 - 3-hydroxyisobutyrate dehydrogenase%2C mitochondrial Acetylation%3B Branched-chain amino acid catabolism%3B Mitochondrion%3B NAD%3B Oxidoreductase%3B Transit peptide%3B Belongs to the 3-hydroxyisobutyrate dehydrogenase family%3B KEGG: gox:GOX1801 null%3B With NAD(+) or NADP(+) as acceptor gene gene2121 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02122 S101447_02123 S101447_02123 S101447_02123 2222062 2222682 + Sulfoxide reductase heme-binding subunit YedZ Cell inner membrane%3B Cell membrane%3B Electron transport%3B Flavoprotein%3B FMN%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY%3B Belongs to the YedZ family gene gene2122 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02123 S101447_02124 S101447_02124 S101447_02124 2222749 2224206 - Putative sulfate transporter YbaR Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the SLC26A/SulP transporter (TC 2. A. 53) family%3B Contains 1 STAS domain gene gene2123 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02124 S101447_02125 S101447_02125 lpxB lpxB 2224391 2225578 + Lipid-A-disaccharide synthase Glycosyltransferase%3B Lipid A biosynthesis%3B Lipid biosynthesis%3B Lipid metabolism%3B Transferase%3B Condensation of UDP-2%2C3-diacylglucosamine and 2%2C3- diacylglucosamine-1-phosphate to form lipid A disaccharide%2C a precursor of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the LpxB family%3B KEGG: apt:APA01_17390 lipid-A-disaccharide synthase gene gene2124 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02125 S101447_02126 S101447_02126 hisI hisI 2225585 2226004 - Phosphoribosyl-AMP cyclohydrolase Amino-acid biosynthesis%3B ATP-binding%3B Chloroplast%3B Histidine biosynthesis%3B Hydrolase%3B Multifunctional enzyme%3B Nucleotide-binding%3B Plastid%3B Transit peptide%3B In the N-terminal sectio%3B belongs to the PRA-CH family%3B In the C-terminal sectio%3B belongs to the PRA-PH family%3B KEGG: apt:APA01_17380 phosphoribosyl-AMP cyclohydrolase gene gene2125 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02126 S101447_02127 S101447_02127 S101447_02127 2226001 2226876 - Putative transferase CAF17%2C mitochondrial Mitochondrion%3B Transferase%3B Transit peptide%3B Belongs to the GcvT family. CAF17 subfamily gene gene2126 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02127 S101447_02128 S101447_02128 asnB asnB 2226960 2228720 - Asparagine synthase (glutamine-hydrolyzing) Amino-acid biosynthesis%3B Asparagine biosynthesis%3B ATP-binding%3B Glutamine amidotransferase%3B Ligase%3B Nucleotide-binding%3B Belongs to the asparagine synthetase family%3B Contains 1 glutamine amidotransferase type-2 domain%3B KEGG: apt:APA01_17360 asparagine synthase (glutamine-hydrolysing) gene gene2127 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02128 S101447_02129 S101447_02129 epsD epsD 2228721 2229782 - Lipopolysaccharide core biosynthesis glycosyltransferase LpsD Glycosyltransferase%3B Lipopolysaccharide biosynthesis%3B Transferase%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: psab:PSAB_04170 glycosyltransferase EpsD%3B Glycosyltransferases gene gene2128 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02129 S101447_02130 S101447_02130 S101447_02130 2229779 2230744 - ADP-heptose--LPS heptosyltransferase Glycosyltransferase%3B Lipopolysaccharide biosynthesis%3B Transferase%3B Belongs to the glycosyltransferase 9 family gene gene2129 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02130 S101447_02131 S101447_02131 S101447_02131 2230834 2231229 + hypothetical protein gene gene2130 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02131 S101447_02132 S101447_02132 S101447_02132 2231386 2232081 + hypothetical protein gene gene2131 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02132 S101447_02133 S101447_02133 S101447_02133 2232086 2233483 + Outer membrane protein assembly factor BamB Cell outer membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Part of the outer membrane protein assembly complex%2C which is involved in assembly and insertion of beta-barrel proteins into the outer membrane%3B Belongs to the BamB family gene gene2132 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02133 S101447_02134 S101447_02134 S101447_02134 2233476 2234915 + GTPase Der GTP-binding%3B Nucleotide-binding%3B Repeat%3B Ribosome biogenesis%3B GTPase that plays an essential role in the late steps of ribosome biogenesis%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngA (Der) GTPase family%3B Contains 2 EngA-type G (guanine nucleotide-binding) domains%3B Contains 1 KH-like domain gene gene2133 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02134 S101447_02135 S101447_02135 S101447_02135 2235197 2236588 + Antiseptic resistance protein Antibiotic resistance%3B Cell membrane%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes%2C quaternary ammonium salts and diamidines%3B Belongs to the major facilitator superfamily gene gene2134 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02135 S101447_02136 S101447_02136 gshA gshA 2236625 2238034 - Glutamate--cysteine ligase ATP-binding%3B Chloroplast%3B Disulfide bond%3B Glutathione biosynthesis%3B Ligase%3B Nucleotide-binding%3B Plastid%3B Transit peptide%3B Belongs to the carboxylate-amine ligase family. Glutamate--cysteine ligase type 2 subfamily%3B KEGG: gox:GOX1977 glutamate--cysteine ligase gene gene2135 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02136 S101447_02137 S101447_02137 rsmE rsmE 2238103 2238876 - 16S rRNA (uracil(1498)-N(3))-methyltransferase Cytoplasm%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)%3B Belongs to the RNA methyltransferase RsmE family%3B KEGG: apt:APA01_17260 16S rRNA (uracil1498-N3)-methyltransferase gene gene2136 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02137 S101447_02138 S101447_02138 ubiA ubiA 2238985 2239902 + 4-hydroxybenzoate polyprenyltransferase Alternative splicing%3B Isoprene biosynthesis%3B Membrane%3B Mitochondrion%3B Mitochondrion inner membrane%3B Transferase%3B Transit peptide%3B Transmembrane%3B Transmembrane helix%3B Ubiquinone biosynthesis%3B Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis%2C which is the condensation of the polyisoprenoid side chain with PHB%2C generating the first membrane-bound Q intermediate. Required for embryo development%3B Belongs to the UbiA prenyltransferase family%3B KEGG: apt:APA01_17250 4-hydroxybenzoate polyprenyltransferase gene gene2137 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02138 S101447_02139 S101447_02139 S101447_02139 2239909 2240604 + hypothetical protein gene gene2138 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02139 S101447_02140 S101447_02140 S101447_02140 2240710 2242071 + putative AAA domain-containing protein YrvN ATP-binding%3B Nucleotide-binding%3B Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily gene gene2139 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02140 S101447_02141 S101447_02141 rluC rluC 2242088 2243074 + 23S rRNA pseudouridine(955/2504/2580) synthase Isomerase%3B RNA-binding%3B rRNA processing%3B Responsible for synthesis of pseudouridine from uracil at positions 955%2C 2504 and 2580 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RluA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: apt:APA01_17220 23S rRNA pseudouridine955/2504/2580 synthase gene gene2140 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02141 S101447_02142 S101447_02142 S101447_02142 2243107 2245260 + hypothetical protein gene gene2141 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02142 S101447_02143 S101447_02143 S101447_02143 2245257 2246024 + ATP synthase mitochondrial F1 complex assembly factor Chaperone%3B Disease mutation%3B Mitochondrion%3B Transit peptide%3B May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase)%3B Belongs to the ATP12 family gene gene2142 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02143 S101447_02144 S101447_02144 S101447_02144 2246128 2246643 + hypothetical protein gene gene2143 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02144 S101447_02145 S101447_02145 S101447_02145 2246718 2248163 + Signal recognition particle protein Cytoplasm%3B GTP-binding%3B Nucleotide-binding%3B Ribonucleoprotein%3B RNA-binding%3B Signal recognition particle%3B Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY%3B Belongs to the GTP-binding SRP family. SRP54 subfamily gene gene2144 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02145 S101447_02146 S101447_02146 S101447_02146 2248226 2248579 + 30S ribosomal protein S16 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein S16P family gene gene2145 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02146 S101447_02147 S101447_02147 S101447_02147 2248594 2249136 + Ribosome maturation factor RimM Chaperone%3B Cytoplasm%3B Ribosome biogenesis%3B An accessory protein needed during the final step in the assembly of 30S ribosomal subunit%2C possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes%3B Belongs to the RimM family%3B Contains 1 PRC barrel domain gene gene2146 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02147 S101447_02148 S101447_02148 trmD trmD 2249133 2249885 + tRNA (guanine(37)-N(1))-methyltransferase Cytoplasm%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B tRNA processing%3B Specifically methylates guanosine-37 in various tRNAs%3B Belongs to the RNA methyltransferase TrmD family%3B KEGG: avi:Avi_4208 tRNA (guanine37-N1)-methyltransferase gene gene2147 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02148 S101447_02149 S101447_02149 S101447_02149 2249900 2250283 + 50S ribosomal protein L19 Ribonucleoprotein%3B Ribosomal protein%3B This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site%3B Belongs to the ribosomal protein L19P family gene gene2148 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02149 S101447_02150 S101447_02150 leuC leuC 2250437 2251840 + 3-isopropylmalate dehydratase 4Fe-4S%3B Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Iron%3B Iron-sulfur%3B Leucine biosynthesis%3B Lyase%3B Metal-binding%3B Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate%2C via the formation of 2-isopropylmaleate. Belongs to the aconitase/IPM isomerase family%3B KEGG: son:SO_4234 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit%3B overlaps another CDS with the same product name gene gene2149 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02150 S101447_02151 S101447_02151 leuD leuD 2251840 2252463 + 3-isopropylmalate dehydratase 4Fe-4S%3B Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Iron%3B Iron-sulfur%3B Leucine biosynthesis%3B Lyase%3B Metal-binding%3B Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate%2C via the formation of 2-isopropylmaleate. Belongs to the aconitase/IPM isomerase family%3B KEGG: msu:MS0334 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit%3B overlaps another CDS with the same product name gene gene2150 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02151 S101447_02152 S101447_02152 leuB leuB 2252482 2253603 + 3-isopropylmalate dehydrogenase Amino-acid biosynthesis%3B Branched-chain amino acid biosynthesis%3B Cytoplasm%3B Leucine biosynthesis%3B Magnesium%3B Manganese%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate%3B Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily%3B KEGG: apt:APA01_17110 3-isopropylmalate dehydrogenase gene gene2151 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02152 S101447_02153 S101447_02153 S101447_02153 2253754 2253957 - 30S ribosomal protein S21 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein S21P family gene gene2152 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02153 S101447_02154 S101447_02154 S101447_02154 2254171 2254695 + Peptide deformylase Hydrolase%3B Iron%3B Metal-binding%3B Protein biosynthesis%3B Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions%3B Belongs to the polypeptide deformylase family%3B KEGG: apt:APA01_17090 peptide deformylase gene gene2153 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02154 S101447_02155 S101447_02155 S101447_02155 2254705 2255358 + hypothetical protein gene gene2154 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02155 S101447_02156 S101447_02156 S101447_02156 2255387 2255908 + HTH-type transcriptional regulator PetP DNA-binding%3B Transcription%3B Transcription regulation%3B Necessary for photosynthetic and respiratory growth. Contains 1 HTH marR-type DNA-binding domain gene gene2155 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02156 S101447_02157 S101447_02157 S101447_02157 2255898 2256620 + Transcriptional regulatory protein AfsQ1 Cytoplasm%3B DNA-binding%3B Phosphoprotein%3B Transcription%3B Transcription regulation%3B Two-component regulatory system%3B Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism. Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2156 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02157 S101447_02158 S101447_02158 envZ envZ 2256697 2258013 + Histidine kinase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Kinase%3B Membrane%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Two-component regulatory system%3B Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals. Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: gox:GOX0120 two-component system%2C OmpR family%2C osmolarity sensor histidine kinase EnvZ gene gene2157 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02158 S101447_02159 S101447_02159 S101447_02159 2258026 2258589 - hypothetical protein gene gene2158 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02159 S101447_02160 S101447_02160 S101447_02160 2258836 2259390 + hypothetical protein gene gene2159 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02160 S101447_02161 S101447_02161 S101447_02161 2259555 2259758 + 50S ribosomal protein L32 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein L32P family gene gene2160 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02161 S101447_02162 S101447_02162 plsX plsX 2259846 2260952 + Glycerol-3-phosphate 1-O-acyltransferase Cytoplasm%3B Lipid biosynthesis%3B Lipid metabolism%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B Transferase%3B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor%2C but not acyl-CoA%3B Belongs to the PlsX family%3B KEGG: apt:APA01_17010 glycerol-3-phosphate acyltransferase PlsX gene gene2161 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02162 S101447_02163 S101447_02163 fabH fabH 2261017 2261997 + Beta-ketoacyl-[acyl-carrier-protein] synthase III Acyltransferase%3B Cytoplasm%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Multifunctional enzyme%3B Transferase%3B Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids%3B Belongs to the FabH family%3B KEGG: apt:APA01_17000 3-oxoacyl-(acyl-carrier-protein) synthase III gene gene2162 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02163 S101447_02164 S101447_02164 S101447_02164 2262070 2262390 + DNA-binding protein HU DNA condensation%3B DNA-binding%3B Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it%2C and thus to prevent its denaturation under extreme environmental conditions. Belongs to the bacterial histone-like protein family gene gene2163 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02164 S101447_02165 S101447_02165 ubp8 ubp8 2262383 2263321 + Ubiquitinyl hydrolase 1 DNA-binding%3B Transcription%3B Transcription regulation%3B Contains 1 HTH merR-type DNA-binding domain%3B KEGG: ocu:100358556 ubiquitin carboxyl-terminal hydrolase 22/27/51 gene gene2164 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02165 S101447_02166 S101447_02166 S101447_02166 2263386 2263459 + tRNA-Pro tRNA gene2165 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02166 S101447_02167 S101447_02167 S101447_02167 2263503 2264624 - UPF0118 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0118 (PerM) family gene gene2166 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02167 S101447_02168 S101447_02168 S101447_02168 2264850 2266400 + Putative lipid II flippase MurJ Cell inner membrane%3B Cell membrane%3B Cell shape%3B Cell wall biogenesis/degradation%3B Membrane%3B Peptidoglycan synthesis%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane (By similarity)%3B Belongs to the MurJ/MviN family gene gene2167 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02168 S101447_02169 S101447_02169 S101447_02169 2266428 2267690 + DNA-directed DNA polymerase KEGG: apt:APA01_16940 DNA polymerase bacteriophage-type gene gene2168 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02169 S101447_02170 S101447_02170 S101447_02170 2267682 2268128 - Integration host factor subunit alpha DNA recombination%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Translation regulation%3B This protein is one of the two subunits of integration host factor%2C a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control%3B Belongs to the bacterial histone-like protein family gene gene2169 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02170 S101447_02171 S101447_02171 S101447_02171 2268145 2268609 - Putative MucR family transcriptional regulatory protein DNA-binding%3B Plasmid%3B Transcription%3B Transcription regulation%3B Belongs to the ros/MucR family gene gene2170 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02171 S101447_02172 S101447_02172 S101447_02172 2269111 2269992 - HTH-type transcriptional regulator TcbR Activator%3B Aromatic hydrocarbons catabolism%3B DNA-binding%3B Plasmid%3B Transcription%3B Transcription regulation%3B Involved in regulation of chlorinated catechol metabolism. Transcriptional activator of the tcbCDEF chlorocatechol oxidative operon. May bind 2-chloromuconate as an inducer. Contains 1 HTH lysR-type DNA-binding domain gene gene2171 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02172 S101447_02173 S101447_02173 S101447_02173 2270109 2271056 - Thioredoxin-disulfide reductase Disulfide bond%3B FAD%3B Flavoprotein%3B NAD%3B NADP%3B Oxidoreductase%3B Redox-active center%3B Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: apt:APA01_16900 thioredoxin reductase (NADPH) gene gene2172 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02173 S101447_02174 S101447_02174 S101447_02174 2271238 2271753 + Bkd operon transcriptional regulator Activator%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Positive regulator of the bkd operon for branched-chain keto acid dehydrogenase complex%3B Contains 1 HTH asnC-type DNA-binding domain gene gene2173 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02174 S101447_02175 S101447_02175 S101447_02175 2271750 2272871 + Dolichyl-phosphate beta-D-mannosyltransferase Endoplasmic reticulum%3B Glycosyltransferase%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation%2C glycosyl phosphatidylinositol membrane anchoring%2C and O- mannosylation of proteins. Belongs to the glycosyltransferase 2 family%3B KEGG: apt:APA01_16880 dolichol-phosphate mannosyltransferase gene gene2174 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02175 S101447_02176 S101447_02176 S101447_02176 2272907 2274364 + Dolichyl-phosphate beta-D-mannosyltransferase KEGG: nit:NAL212_0674 dolichol-phosphate mannosyltransferase gene gene2175 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02176 S101447_02177 S101447_02177 gshB gshB 2274464 2275459 + Glutathione synthase ATP-binding%3B Glutathione biosynthesis%3B Ligase%3B Magnesium%3B Manganese%3B Metal-binding%3B Nucleotide-binding%3B Belongs to the prokaryotic GSH synthase family%3B Contains 1 ATP-grasp domain%3B KEGG: apt:APA01_16860 glutathione synthase gene gene2176 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02177 S101447_02178 S101447_02178 S101447_02178 2275463 2275645 - hypothetical protein gene gene2177 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02178 S101447_02179 S101447_02179 pmtA pmtA 2275755 2276492 + Phosphatidylethanolamine N-methyltransferase Lipid biosynthesis%3B Lipid metabolism%3B Methyltransferase%3B Phospholipid biosynthesis%3B Phospholipid metabolism%3B S-adenosyl-L-methionine%3B Transferase%3B KEGG: apt:APA01_16840 phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase gene gene2178 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02179 S101447_02180 S101447_02180 coxA coxA 2276649 2277905 + Cytochrome-c oxidase Copper%3B Electron transport%3B Heme%3B Iron%3B Lipoprotein%3B Membrane%3B Metal-binding%3B Mitochondrion%3B Mitochondrion inner membrane%3B Myristate%3B Oxidoreductase%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. Belongs to the heme-copper respiratory oxidase family%3B KEGG: ccr:CC_3406 cytochrome c oxidase subunit I gene gene2179 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02180 S101447_02181 S101447_02181 cyoE cyoE 2277902 2278870 + Protoheme IX farnesyltransferase Cell inner membrane%3B Cell membrane%3B Heme biosynthesis%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group%3B Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily%3B KEGG: apt:APA01_16820 protoheme IX farnesyltransferase%3B Transferring alkyl or aryl groups%2C other than methyl groups gene gene2180 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02181 S101447_02182 S101447_02182 S101447_02182 2278861 2279010 + hypothetical protein gene gene2181 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02182 S101447_02183 S101447_02183 S101447_02183 2279075 2279266 - hypothetical protein gene gene2182 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02183 S101447_02184 S101447_02184 S101447_02184 2279356 2280327 - hypothetical protein gene gene2183 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02184 S101447_02185 S101447_02185 S101447_02185 2280354 2281694 - Metalloprotease PmbA like protein Cytoplasm%3B Hydrolase%3B Metalloprotease%3B Protease%3B Probable metalloprotease%3B Belongs to the peptidase U62 family gene gene2184 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02185 S101447_02186 S101447_02186 S101447_02186 2281691 2282956 - Mitochondrial-processing peptidase subunit beta Hydrolase%3B Metal-binding%3B Metalloprotease%3B Mitochondrion%3B Protease%3B Transit peptide%3B Zinc%3B Cleaves presequences (transit peptides) from mitochondrial protein precursors. Belongs to the peptidase M16 family%3B KEGG: dds:Ddes_1070 zinc protease%3B Metalloendopeptidases gene gene2185 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02186 S101447_02187 S101447_02187 thrC thrC 2283023 2284423 - Threonine synthase Amino-acid biosynthesis%3B Lyase%3B Pyridoxal phosphate%3B Threonine biosynthesis%3B Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine%3B Belongs to the threonine synthase family%3B KEGG: pae:PA3735 threonine synthase gene gene2186 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02187 S101447_02188 S101447_02188 S101447_02188 2284490 2285641 - hypothetical protein gene gene2187 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02188 S101447_02189 S101447_02189 S101447_02189 2285788 2287197 - Carboxypeptidase Taq Carboxypeptidase%3B Hydrolase%3B Metal-binding%3B Metalloprotease%3B Protease%3B Zinc%3B Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus%2C including neutral%2C aromatic%2C polar and basic residues. Has lower activity with substrates ending with His or Trp%3B Belongs to the peptidase M32 family%3B KEGG: apt:APA01_16750 carboxypeptidase Taq gene gene2188 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02189 S101447_02190 S101447_02190 S101447_02190 2287292 2289256 + Protein O-GlcNAc transferase Glycoprotein%3B Membrane%3B Repeat%3B TPR repeat%3B Transmembrane%3B Transmembrane helix%3B Belongs to the TMTC family%3B Contains 10 TPR repeats%3B KEGG: bvg:104889767 protein O-GlcNAc transferase gene gene2189 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02190 S101447_02191 S101447_02191 S101447_02191 2289297 2291951 + DNA mismatch repair protein MutS ATP-binding%3B DNA damage%3B DNA repair%3B DNA-binding%3B Nucleotide-binding%3B This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity%3B Belongs to the DNA mismatch repair MutS family gene gene2190 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02191 S101447_02192 S101447_02192 glnD glnD 2291957 2294947 + [Protein-PII] uridylyltransferase Hydrolase%3B Magnesium%3B Multifunctional enzyme%3B Nucleotidyltransferase%3B Repeat%3B Transferase%3B Under low glutamine levels%2C catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi%2C while under higher glutamine levels%2C GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus%2C controls uridylylation state and activity of the PII proteins%2C and plays an important role in the regulation of nitrogen assimilation and metabolism%3B Belongs to the GlnD family%3B Contains 2 ACT domains%3B Contains 1 HD domain%3B KEGG: apt:APA01_16720 (protein-PII) uridylyltransferase gene gene2191 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02192 S101447_02193 S101447_02193 thiN thiN 2294952 2295824 - Thiamine diphosphokinase Alternative splicing%3B Chloroplast%3B Hydrolase%3B Magnesium%3B Manganese%3B Metal-binding%3B Plastid%3B Transit peptide%3B Probably mediates the hydrolysis of some nucleoside diphosphate derivatives%3B Belongs to the Nudix hydrolase family%3B Contains 1 nudix hydrolase domain%3B KEGG: gox:GOX0109 thiamine pyrophosphokinase gene gene2192 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02193 S101447_02194 S101447_02194 S101447_02194 2295934 2297757 + ATM1-type heavy metal exporter ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Mercuric resistance%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Mediates the ATP-dependent export of glutathione- conjugated substrates%2C such as heavy metal-glutathione conjugates. ATP hydrolysis is stimulated by glutathione binding. Protects cells against toxic heavy metal ions%2C such as silver and mercury ions. May also mediate the transport of glutathione-conjugated aromatic hydrocarbons%2C such as dinitrobenzene%3B Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3. A. 1. 210) subfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene2193 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02194 S101447_02195 S101447_02195 S101447_02195 2297854 2298147 + hypothetical protein gene gene2194 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02195 S101447_02196 S101447_02196 S101447_02196 2298265 2298570 + 50S ribosomal protein L28 Ribonucleoprotein%3B Ribosomal protein%3B Belongs to the ribosomal protein L28P family gene gene2195 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02196 S101447_02197 S101447_02197 S101447_02197 2298800 2300887 + Elongation factor Cytoplasm%3B Elongation factor%3B GTP-binding%3B Nucleotide-binding%3B Protein biosynthesis%3B Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step%2C the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites%2C respectively. Catalyzes the coordinated movement of the two tRNA molecules%2C the mRNA and conformational changes in the ribosome%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene2196 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02197 S101447_02198 S101447_02198 S101447_02198 2301068 2302060 + Non-heme bromoperoxidase BPO-A2 Antibiotic biosynthesis%3B Oxidoreductase%3B Peroxidase%3B Plasmid%3B May be a chlorinating enzyme involved in 7- chlorotetracycline biosynthesis. Belongs to the bacterial non-heme bromo- and chloro- peroxidases family%3B KEGG: aau:AAur_0584 peroxiredoxin%3B Peroxidases gene gene2197 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02198 S101447_02199 S101447_02199 S101447_02199 2302109 2304907 - Phosphoenolpyruvate carboxylase KEGG: apt:APA01_16650 phosphoenolpyruvate carboxylase gene gene2198 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02199 S101447_02200 S101447_02200 S101447_02200 2305078 2306376 + uncharacterized protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix. gene gene2199 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02200 S101447_02201 S101447_02201 S101447_02201 2306500 2306964 + Putative HTH-type transcriptional regulator DNA-binding%3B Contains 1 HTH rrf2-type DNA-binding domain gene gene2200 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02201 S101447_02202 S101447_02202 S101447_02202 2306968 2308458 + UPF0051 protein Belongs to the UPF0051 (ycf24) family gene gene2201 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02202 S101447_02203 S101447_02203 S101447_02203 2308472 2309242 + Vegetative protein 296 ATP-binding%3B Nucleotide-binding%3B Transport%3B Belongs to the ABC transporter superfamily. Ycf16 family%3B Contains 1 ABC transporter domain gene gene2202 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02203 S101447_02204 S101447_02204 S101447_02204 2309239 2310522 + Protein ABCI7%2C chloroplastic Chloroplast%3B Plastid%3B Transit peptide. gene gene2203 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02204 S101447_02205 S101447_02205 sufS sufS 2310522 2311769 + Cysteine desulfurase Pyridoxal phosphate%3B Transferase%3B Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine%2C L-cystine%2C L-selenocysteine%2C and L- selenocystine to produce L-alanine%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily%3B KEGG: apt:APA01_16590 cysteine desulfurase / selenocysteine lyase gene gene2204 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02205 S101447_02206 S101447_02206 S101447_02206 2311766 2312218 + hypothetical protein gene gene2205 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02206 S101447_02207 S101447_02207 S101447_02207 2312205 2312693 + uncharacterized protein gene gene2206 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02207 S101447_02208 S101447_02208 S101447_02208 2312720 2313088 + Iron-binding protein IscA Iron%3B Metal-binding%3B Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed%2C suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS%2C L-cysteine and the thioredoxin reductase system TrxA/TrxB%3B Belongs to the HesB/IscA family gene gene2207 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02208 S101447_02209 S101447_02209 rumA rumA 2313042 2314340 - 23S rRNA (uracil(1939)-C(5))-methyltransferase 4Fe-4S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily%3B Contains 1 TRAM domain%3B KEGG: apt:APA01_16550 23S rRNA (uracil1939-C5)-methyltransferase gene gene2208 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02209 S101447_02210 S101447_02210 S101447_02210 2314349 2316262 - Ribonuclease E ATP-binding%3B Cytoplasm%3B Helicase%3B Hydrolase%3B mRNA processing%3B mRNA splicing%3B Nucleotide-binding%3B Nucleus%3B Probable ATP-binding RNA helicase which may be involved in pre-mRNA splicing%3B Belongs to the DEAD box helicase family. DDX20 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: cna:AB433_07985 ribonuclease E gene gene2209 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02210 S101447_02211 S101447_02211 S101447_02211 2316443 2316898 - hypothetical protein gene gene2210 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02211 S101447_02212 S101447_02212 S101447_02212 2317057 2318532 + ADP-dependent NAD(P)H-hydrate dehydratase Isomerase%3B Metal-binding%3B NAD%3B NADP%3B Nucleotide-binding%3B Potassium%3B Catalyzes the epimerization of the S- and R-forms of NAD(P)HX%2C a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX%3B Belongs to the NnrE/AIBP family%3B Contains 1 YjeF N-terminal domain%3B KEGG: mew:MSWAN_2193 ADP-dependent NAD(P)H-hydrate dehydratase gene gene2211 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02212 S101447_02213 S101447_02213 S101447_02213 2318572 2318656 + tRNA-Leu tRNA gene2212 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02213 S101447_02214 S101447_02214 S101447_02214 2318746 2320080 + Trigger factor Cell cycle%3B Cell division%3B Chaperone%3B Cytoplasm%3B Isomerase%3B Rotamase%3B Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase%3B Belongs to the FKBP-type PPIase family. Tig subfamily%3B Contains 1 PPIase FKBP-type domain gene gene2213 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02214 S101447_02215 S101447_02215 S101447_02215 2320264 2320917 + Endopeptidase Clp Cytoplasm%3B Hydrolase%3B Protease%3B Serine protease%3B Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins%3B Belongs to the peptidase S14 family%3B KEGG: bid:Bind_2184 ATP-dependent Clp protease%2C protease subunit gene gene2214 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02215 S101447_02216 S101447_02216 S101447_02216 2321038 2322303 + ATP-dependent Clp protease ATP-binding subunit ClpX ATP-binding%3B Chaperone%3B Metal-binding%3B Nucleotide-binding%3B Zinc%3B Zinc-finger%3B ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP%3B Belongs to the ClpX chaperone family gene gene2215 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02216 S101447_02217 S101447_02217 S101447_02217 2322502 2325027 + Endopeptidase La ATP-binding%3B Cytoplasm%3B Hydrolase%3B Nucleotide-binding%3B Protease%3B Serine protease%3B Stress response%3B ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Binds to DNA in a double-stranded%2C site-specific manner%3B Belongs to the peptidase S16 family%3B Contains 1 Lon domain%3B KEGG: apt:APA01_16470 ATP-dependent Lon protease gene gene2216 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02217 S101447_02218 S101447_02218 S101447_02218 2325173 2325460 + DNA-binding protein HRL18 DNA condensation%3B DNA-binding%3B Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it%2C and thus to prevent its denaturation under extreme environmental conditions. Belongs to the bacterial histone-like protein family gene gene2217 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02218 S101447_02219 S101447_02219 S101447_02219 2325548 2325622 + tRNA-Val tRNA gene2218 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02219 S101447_02220 S101447_02220 S101447_02220 2325852 2326217 + NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 3 family%3B KEGG: neu:NE1777 NADH-quinone oxidoreductase subunit A gene gene2219 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02220 S101447_02221 S101447_02221 S101447_02221 2326236 2326796 + NADH:ubiquinone reductase (H(+)-translocating) 4Fe-4S%3B Cell inner membrane%3B Cell membrane%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Quinone%3B Transport%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient (By similarity)%3B Belongs to the complex I 20 kDa subunit family%3B KEGG: apt:APA01_16420 NADH-quinone oxidoreductase subunit B%3B overlaps another CDS with the same product name gene gene2220 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02221 S101447_02222 S101447_02222 nuoC nuoC 2326789 2327448 + NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transport%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I 30 kDa subunit family%3B KEGG: apt:APA01_16410 NADH-quinone oxidoreductase subunit C%3B overlaps another CDS with the same product name gene gene2221 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02222 S101447_02223 S101447_02223 nuoD nuoD 2327448 2328728 + NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transport%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I 49 kDa subunit family%3B KEGG: apt:APA01_16400 NADH-quinone oxidoreductase subunit D%3B overlaps another CDS with the same product name gene gene2222 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02223 S101447_02224 S101447_02224 S101447_02224 2328725 2329366 + NADH:ubiquinone reductase (H(+)-translocating) 2Fe-2S%3B Electron transport%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B Mitochondrion%3B Mitochondrion inner membrane%3B NAD%3B Oxidoreductase%3B Respiratory chain%3B Transit peptide%3B Transport%3B Ubiquinone%3B Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)%3B Belongs to the complex I 24 kDa subunit family%3B KEGG: apt:APA01_16390 NADH-quinone oxidoreductase subunit E%3B overlaps another CDS with the same product name gene gene2223 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02224 S101447_02225 S101447_02225 S101447_02225 2329378 2330706 + NADH:ubiquinone reductase (H(+)-translocating) 4Fe-4S%3B Electron transport%3B Flavoprotein%3B FMN%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B Mitochondrion%3B Mitochondrion inner membrane%3B NAD%3B Oxidoreductase%3B Respiratory chain%3B Transit peptide%3B Transport%3B Ubiquinone%3B Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)%3B Belongs to the complex I 51 kDa subunit family%3B KEGG: eru:Erum4810 NADH-quinone oxidoreductase subunit F gene gene2224 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02225 S101447_02226 S101447_02226 S101447_02226 2330712 2332790 + NADH:ubiquinone reductase (H(+)-translocating) 2Fe-2S%3B 4Fe-4S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Quinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient (By similarity)%3B Belongs to the complex I 75 kDa subunit family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 4Fe-4S Mo/W bis-MGD-type domain%3B KEGG: rpr:RP797 NADH-quinone oxidoreductase subunit G gene gene2225 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02226 S101447_02227 S101447_02227 S101447_02227 2332796 2333824 + NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone%3B Belongs to the complex I subunit 1 family%3B KEGG: gxy:GLX_08700 NADH-quinone oxidoreductase subunit H%3B overlaps another CDS with the same product name gene gene2226 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02227 S101447_02228 S101447_02228 S101447_02228 2333824 2334312 + NADH:ubiquinone reductase (H(+)-translocating) 4Fe-4S%3B Cell inner membrane%3B Cell membrane%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Quinone%3B Repeat%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I 23 kDa subunit family%3B Contains 2 4Fe-4S ferredoxin-type domains%3B KEGG: apt:APA01_16350 NADH-quinone oxidoreductase subunit I%3B overlaps another CDS with the same product name gene gene2227 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02228 S101447_02229 S101447_02229 S101447_02229 2334349 2335062 + NADH:ubiquinone reductase (H(+)-translocating) Chloroplast%3B Membrane%3B NAD%3B NADP%3B Oxidoreductase%3B Plastid%3B Plastoquinone%3B Quinone%3B Thylakoid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B NDH shuttles electrons from NAD(P)H:plastoquinone%2C via FMN and iron-sulfur (Fe-S) centers%2C to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation%2C and thus conserves the redox energy in a proton gradient (By similarity)%3B Belongs to the complex I subunit 6 family%3B KEGG: mmr:Mmar10_1364 NADH-quinone oxidoreductase subunit J%3B overlaps another CDS with the same product name gene gene2228 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02229 S101447_02230 S101447_02230 S101447_02230 2335059 2335382 + NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 4L family%3B KEGG: apt:APA01_16330 NADH-quinone oxidoreductase subunit K%3B overlaps another CDS with the same product name gene gene2229 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02230 S101447_02231 S101447_02231 S101447_02231 2335389 2337329 + NADH:ubiquinone reductase (H(+)-translocating) Electron transport%3B Membrane%3B Mitochondrion%3B Mitochondrion inner membrane%3B NAD%3B Oxidoreductase%3B Respiratory chain%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone%3B Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)%3B Belongs to the complex I subunit 5 family%3B KEGG: apt:APA01_16320 NADH-quinone oxidoreductase subunit L gene gene2230 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02231 S101447_02232 S101447_02232 S101447_02232 2337402 2338844 + NADH:ubiquinone reductase (H(+)-translocating) Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Oxidoreductase%3B Quinone%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Ubiquinone%3B NDH-1 shuttles electrons from NADH%2C via FMN and iron- sulfur (Fe-S) centers%2C to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred%2C four hydrogen ions are translocated across the cytoplasmic membrane)%2C and thus conserves the redox energy in a proton gradient%3B Belongs to the complex I subunit 2 family%3B KEGG: apt:APA01_16310 NADH-quinone oxidoreductase subunit N gene gene2231 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02232 S101447_02233 S101447_02233 birA birA 2338841 2339584 + Biotin--[acetyl-CoA-carboxylase] ligase KEGG: apt:APA01_16300 BirA family transcriptional regulator%2C biotin operon repressor / biotin-(acetyl-CoA-carboxylase) ligase gene gene2232 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02233 S101447_02234 S101447_02234 coaX coaX 2339589 2340398 + Pantothenate kinase ATP-binding%3B Coenzyme A biosynthesis%3B Cytoplasm%3B Kinase%3B Metal-binding%3B Nucleotide-binding%3B Potassium%3B Transferase%3B Catalyzes the phosphorylation of pantothenate (Pan)%2C the first step in CoA biosynthesis%3B Belongs to the type III pantothenate kinase family%3B KEGG: gox:GOX0081 type III pantothenate kinase gene gene2233 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02234 S101447_02235 S101447_02235 S101447_02235 2340408 2342051 + Ribonuclease J2 Cytoplasm%3B Endonuclease%3B Exonuclease%3B Hydrolase%3B Metal-binding%3B Nuclease%3B RNA-binding%3B rRNA processing%3B Zinc%3B Endonucleolytically cleaves the 5'-leader sequence of certain mRNAs. Endonuclease digestion by the RNase J1/J2 complex occurs at a different site and in some cases more efficiently than J1 or J2 alone. The exonuclease activity of the J1/J2 complex is highly processive on substrates longer than 5 nucleotides%2C on shorter substrates is distributive. Plays a role in mRNA maturation and stability. Appears to have a limited effect on 16S rRNA maturation%2C despite its similarity to RNase J1. This subunit alone has very poor 5'-3' exonuclease activity%3B Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily%3B KEGG: apt:APA01_16280 ribonuclease J%3B Acting on ester bonds gene gene2234 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02235 S101447_02236 S101447_02236 parS parS 2342198 2343514 + Proline--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine%2C to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS%3B Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily%3B KEGG: tin:Tint_0517 prolyl-tRNA synthetase gene gene2235 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02236 S101447_02237 S101447_02237 S101447_02237 2343520 2344767 + Lipoprotein-releasing system transmembrane protein LolC Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity)%3B Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily gene gene2236 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02237 S101447_02238 S101447_02238 lolD lolD 2344760 2345482 + Macrolide export ATP-binding/permease protein MacB Antibiotic resistance%3B ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD)%2C which form a pore in the inner membrane%2C and an ATP-binding domain (NBD)%2C which is responsible for energy generation. Confers resistance against macrolides%3B Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3. A. 1. 122) family%3B Contains 1 ABC transporter domain%3B KEGG: apk:APA386B_550 lipoprotein-releasing system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene2237 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02238 S101447_02239 S101447_02239 S101447_02239 2345486 2345974 - Glutathione peroxidase Oxidoreductase%3B Periplasm%3B Peroxidase%3B Signal%3B Belongs to the glutathione peroxidase family%3B KEGG: apt:APA01_16240 glutathione peroxidase gene gene2238 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02239 S101447_02240 S101447_02240 S101447_02240 2346250 2347047 + HTH-type transcriptional repressor AllR DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region (By similarity)%3B Contains 1 HTH iclR-type DNA-binding domain%3B Contains 1 iclR-ED (iclR effector binding) domain gene gene2239 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02240 S101447_02241 S101447_02241 S101447_02241 2347069 2347902 + hypothetical protein gene gene2240 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02241 S101447_02242 S101447_02242 glmS glmS 2347945 2349768 - Glutamine--fructose-6-phosphate transaminase (isomerizing) Aminotransferase%3B Cytoplasm%3B Glutamine amidotransferase%3B Repeat%3B Transferase%3B Catalyzes the first step in hexosamine metabolism%2C converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source%3B Contains 1 glutamine amidotransferase type-2 domain%3B Contains 2 SIS domains%3B KEGG: gox:GOX0007 glucosamine--fructose-6-phosphate aminotransferase (isomerizing) gene gene2241 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02242 S101447_02243 S101447_02243 glmU glmU 2349768 2351144 - UDP-N-acetylglucosamine diphosphorylase Acyltransferase%3B Cell shape%3B Cell wall biogenesis/degradation%3B Cytoplasm%3B Magnesium%3B Metal-binding%3B Multifunctional enzyme%3B Nucleotidyltransferase%3B Peptidoglycan synthesis%3B Repeat%3B Transferase%3B Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P)%2C which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate)%2C a reaction catalyzed by the N-terminal domain%3B In the N-terminal sectio%3B belongs to the N- acetylglucosamine-1-phosphate uridyltransferase family%3B In the C-terminal sectio%3B belongs to the transferase hexapeptide repeat family%3B KEGG: apt:APA01_16150 bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase gene gene2242 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02243 S101447_02244 S101447_02244 S101447_02244 2351227 2351925 + Phosphoglycolate phosphatase Carbohydrate metabolism%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends%2C a major class of DNA lesions induced by oxidative stress%3B Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family%3B KEGG: apt:APA01_16140 phosphoglycolate phosphatase gene gene2243 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02244 S101447_02245 S101447_02245 S101447_02245 2351939 2352745 - hypothetical protein gene gene2244 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02245 S101447_02246 S101447_02246 S101447_02246 2352742 2353527 - hypothetical protein gene gene2245 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02246 S101447_02247 S101447_02247 S101447_02247 2353524 2354618 - hypothetical protein gene gene2246 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02247 S101447_02248 S101447_02248 S101447_02248 2354615 2355850 - hypothetical protein gene gene2247 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02248 S101447_02249 S101447_02249 S101447_02249 2355811 2356569 - hypothetical protein gene gene2248 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02249 S101447_02250 S101447_02250 S101447_02250 2356857 2357837 + hypothetical protein gene gene2249 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02250 S101447_02251 S101447_02251 S101447_02251 2357862 2358815 + hypothetical protein gene gene2250 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02251 S101447_02252 S101447_02252 S101447_02252 2358821 2360035 - 8-amino-7-oxononanoate synthase Biotin biosynthesis%3B Pyridoxal phosphate%3B Transferase%3B Catalyzes the decarboxylative condensation of pimeloyl- [acyl-carrier protein] and L-alanine to produce 8-amino-7- oxononanoate (AON)%2C [acyl-carrier protein]%2C and carbon dioxide%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily%3B KEGG: apt:APA01_16060 8-amino-7-oxononanoate synthase gene gene2251 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02252 S101447_02253 S101447_02253 S101447_02253 2360042 2360293 - hypothetical protein gene gene2252 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02253 S101447_02254 S101447_02254 S101447_02254 2360426 2362192 - Long-chain-fatty-acid--AMP ligase FadD26 Fatty acid metabolism%3B Ligase%3B Lipid metabolism%3B Catalyzes the activation of long-chain fatty acids (C22- 24 fatty acids) as acyl-adenylates (acyl-AMP)%2C which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension. Involved in the biosynthesis of phthiocerol dimycocerosate (DIM A) and phthiodiolone dimycocerosate (DIM B)%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: apt:APA01_16040 fatty-acyl-CoA synthase%3B Acid--thiol ligases gene gene2253 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02254 S101447_02255 S101447_02255 S101447_02255 2362192 2363322 - hypothetical protein gene gene2254 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02255 S101447_02256 S101447_02256 S101447_02256 2363892 2365379 + 16S ribosomal RNA rRNA gene2255 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02256 S101447_02257 S101447_02257 S101447_02257 2365595 2365671 + tRNA-Ile tRNA gene2256 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02257 S101447_02258 S101447_02258 S101447_02258 2365696 2365771 + tRNA-Ala tRNA gene2257 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02258 S101447_02259 S101447_02259 S101447_02259 2366103 2368845 + 23S ribosomal RNA rRNA gene2258 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02259 S101447_02260 S101447_02260 S101447_02260 2368954 2369069 + 5S ribosomal RNA rRNA gene2259 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02260 S101447_02261 S101447_02261 S101447_02261 2369125 2369201 + tRNA-Met tRNA gene2260 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02261 S101447_02262 S101447_02262 S101447_02262 2369475 2369972 + hypothetical protein gene gene2261 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02262 S101447_02263 S101447_02263 S101447_02263 2370088 2371110 + hypothetical protein gene gene2262 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02263 S101447_02264 S101447_02264 S101447_02264 2371287 2373839 + Ferripyoverdine receptor Cell outer membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Receptor for the siderophore ferripyoverdine. Belongs to the TonB-dependent receptor family gene gene2263 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02264 S101447_02265 S101447_02265 S101447_02265 2373979 2374185 + hypothetical protein gene gene2264 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02265 S101447_02266 S101447_02266 S101447_02266 2374429 2375145 - Transposase InsF for insertion sequence IS3A DNA recombination%3B DNA-binding%3B Transposable element%3B Transposition%3B Involved in the transposition of the insertion sequence IS3. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene2265 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02266 S101447_02267 S101447_02267 S101447_02267 2375445 2375567 - hypothetical protein gene gene2266 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02267 S101447_02268 S101447_02268 S101447_02268 2375677 2376048 + hypothetical protein gene gene2267 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02268 S101447_02269 S101447_02269 S101447_02269 2376357 2377094 - Meiotically up-regulated 14 protein Cytoplasm%3B Meiosis%3B Nucleus%3B Has a role in meiosis gene gene2268 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02269 S101447_02270 S101447_02270 S101447_02270 2377134 2378180 - Gibberellin 2-beta-dioxygenase Alternative splicing%3B Dioxygenase%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Catalyzes the 2-beta-hydroxylation of gibberellins (GA) precursors%2C rendering them unable to be converted to active GAs. Hydroxylates the C20-GA GA12 and GA53%2C but is not active on C19- GAs%2C like GA1%2C GA4%2C GA9 and GA20%3B Belongs to the iron/ascorbate-dependent oxidoreductase family. GA2OX subfamily%3B Contains 1 Fe2OG dioxygenase domain%3B KEGG: aly:ARALYDRAFT_658002 gibberellin 2-oxidase gene gene2269 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02270 S101447_02271 S101447_02271 S101447_02271 2378180 2379046 - hypothetical protein gene gene2270 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02271 S101447_02272 S101447_02272 S101447_02272 2379076 2381349 - hypothetical protein gene gene2271 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02272 S101447_02273 S101447_02273 S101447_02273 2381496 2382248 - Phosphate-transporting ATPase ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3. A. 1. 17. 2) family%3B Contains 1 ABC transporter domain%3B KEGG: ebi:EbC_45760 phosphate transport system ATP-binding protein gene gene2272 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02273 S101447_02274 S101447_02274 S101447_02274 2382238 2383815 - Putative glutamine transport system permease protein GlnP Amino-acid transport%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the binding-protein-dependent transport system for glutamin%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2273 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02274 S101447_02275 S101447_02275 S101447_02275 2383815 2384768 - HTH-type transcriptional activator BauR Activator%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Involved in the degradation of beta-alanine. BauR activates the transcription of the bauABCD operon%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2274 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02275 S101447_02276 S101447_02276 S101447_02276 2384878 2385003 + hypothetical protein gene gene2275 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02276 S101447_02277 S101447_02277 S101447_02277 2385085 2385948 + uncharacterized protein Hydrolase%3B Belongs to the DDAH family gene gene2276 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02277 S101447_02278 S101447_02278 ghrA ghrA 2385983 2386927 + Glyoxylate reductase (NADP(+)) NAD%3B NADP%3B Oxidoreductase%3B Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2- hydroxycarboxylic acids. Can use both NADPH or NADH as reductant%2C displaying a marked preference for NADPH over NADH. Shows a broad substrate specificity%2C although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms%3B Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: gxl:H845_837 glyoxylate/hydroxypyruvate reductase A gene gene2277 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02278 S101447_02279 S101447_02279 S101447_02279 2386963 2388207 + N-carbamoyl-L-amino-acid hydrolase Hydrolase%3B Metal-binding%3B Purine metabolism%3B Zinc%3B Involved in the anaerobic utilization of allantoin. Converts allantoate to (S)-ureidoglycolate and ammonia%3B Belongs to the peptidase M20 family%3B KEGG: dac:Daci_2865 N-carbamoyl-L-amino-acid hydrolase gene gene2278 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02279 S101447_02280 S101447_02280 aofH aofH 2388352 2389953 + Monoamine oxidase KEGG: rce:RC1_3921 monoamine oxidase gene gene2279 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02280 S101447_02281 S101447_02281 S101447_02281 2389953 2390372 + hypothetical protein gene gene2280 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02281 S101447_02282 S101447_02282 S101447_02282 2390789 2390896 - hypothetical protein gene gene2281 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02282 S101447_02283 S101447_02283 S101447_02283 2390990 2393119 - Colicin V secretion/processing ATP-binding protein CvaB ATP-binding%3B Bacteriocin transport%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Plasmid%3B Protease%3B Protein transport%3B Thiol protease%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved%2C in conjunction with CvaA%2C in the secretion of colicin V. Belongs to the ABC transporter superfamily. Colicin V exporter (TC 3. A. 1. 110. 2) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B Contains 1 peptidase C39 domain gene gene2282 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02283 S101447_02284 S101447_02284 S101447_02284 2393116 2394423 - Colicin V secretion protein CvaA Alternative initiation%3B Bacteriocin transport%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Plasmid%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved%2C in conjunction with CvaB%2C in the secretion of colicin V. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene2283 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02284 S101447_02285 S101447_02285 S101447_02285 2394493 2394771 - hypothetical protein gene gene2284 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02285 S101447_02286 S101447_02286 S101447_02286 2394933 2396426 + hypothetical protein gene gene2285 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02286 S101447_02287 S101447_02287 S101447_02287 2396711 2397943 + COBW domain-containing protein ATP-binding%3B Coiled coil%3B Nucleotide-binding%3B Belongs to the SIMIBI class G3E GTPase family. CobW subfamily%3B Contains 1 cobW C-terminal domain gene gene2286 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02287 S101447_02288 S101447_02288 S101447_02288 2397936 2398268 + hypothetical protein gene gene2287 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02288 S101447_02289 S101447_02289 S101447_02289 2398351 2399382 - Prolyl aminopeptidase Aromatic hydrocarbons catabolism%3B Hydrolase%3B Plasmid%3B Serine esterase%3B Catalyzes the conversion of 2-hydroxymuconate semialdehyde to 2-hydroxypent-2%2C4-dienoate. Belongs to the DmpD/TodF/XylF esterase family%3B KEGG: bra:BRADO4325 proline iminopeptidase gene gene2288 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02289 S101447_02290 S101447_02290 S101447_02290 2399379 2400524 - hypothetical protein gene gene2289 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02290 S101447_02291 S101447_02291 S101447_02291 2401299 2401652 + hypothetical protein gene gene2290 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02291 S101447_02292 S101447_02292 S101447_02292 2401867 2402307 + hypothetical protein gene gene2291 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02292 S101447_02293 S101447_02293 S101447_02293 2402575 2403945 - putative transporter YebQ Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the major facilitator superfamily. TCR/Tet family gene gene2292 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02293 S101447_02294 S101447_02294 S101447_02294 2404201 2404593 - hypothetical protein gene gene2293 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02294 S101447_02295 S101447_02295 S101447_02295 2404746 2405186 - hypothetical protein gene gene2294 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02295 S101447_02296 S101447_02296 kduD kduD 2405216 2405977 - 2-deoxy-D-gluconate 3-dehydrogenase Oxidoreductase%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: dfe:Dfer_2838 2-deoxy-D-gluconate 3-dehydrogenase gene gene2295 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02296 S101447_02297 S101447_02297 S101447_02297 2406142 2406777 - HTH-type transcriptional repressor ComR Copper%3B DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Represses expression of BhsA/ComC by binding to its promoter region in the absence of copper%3B Contains 1 HTH tetR-type DNA-binding domain gene gene2296 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02297 S101447_02298 S101447_02298 S101447_02298 2406841 2407554 - L-rhamnose 1-dehydrogenase (NADP(+)) NADP%3B Oxidoreductase%3B Rhamnose metabolism%3B Involved in the non-phosphorylated metabolic pathway of L-rhamnose catabolism. Catalyzes the oxidation of L-rhamnose to yield L-rhamnono-1%2C4-lactone. It can also oxidize L-lyxose and L- mannose%2C and uses only NADP%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family gene gene2297 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02298 S101447_02299 S101447_02299 S101447_02299 2407633 2408067 - hypothetical protein gene gene2298 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02299 S101447_02300 S101447_02300 S101447_02300 2408473 2409783 + Succinate--hydroxymethylglutarate CoA-transferase Acetylation%3B Alternative splicing%3B Disease mutation%3B Glutaricaciduria%3B Mitochondrion%3B Transferase%3B Transit peptide%3B Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors%2C the preferred ones are glutarate%2C succinate%2C adipate%2C and 3-hydroxymethylglutarate%3B Belongs to the CaiB/BaiF CoA-transferase family%3B KEGG: cge:100770206 succinate---hydroxymethylglutarate CoA-transferase gene gene2299 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02300 S101447_02301 S101447_02301 S101447_02301 2409894 2411630 + Oxalyl-CoA decarboxylase Decarboxylase%3B Lyase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Thiamine pyrophosphate%3B Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Essential enzyme for the bacterium survival%2C as it relies on oxalic acid as its sole source of energy. Catalyzes the decarboxylation of oxalyl-CoA to yield carbon dioxide and formyl-CoA%3B Belongs to the TPP enzyme family%3B KEGG: apt:APA01_15720 oxalyl-CoA decarboxylase gene gene2300 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02301 S101447_02302 S101447_02302 uctC uctC 2411640 2412809 + CoA:oxalate CoA-transferase Transferase%3B Involved in the catabolism of oxalate and in the adapatation to low pH. ACOCT serves to prime the oxalate-induced acid tolerance response (ATR) cycle by producing substrate for oxalyl-CoA decarboxylase (OXC) and formyl-coenzyme A transferase (FCOCT). Catalyzes the reversible conversion of acetyl-CoA and oxalate to oxalyl-CoA and acetate. It can also use formyl-CoA and oxalate to produce oxalyl-CoA and formate with significantly reduced specific activity%3B Belongs to the CaiB/BaiF CoA-transferase family%3B KEGG: apt:APA01_15690 CoA:oxalate CoA-transferase gene gene2301 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02302 S101447_02303 S101447_02303 S101447_02303 2412806 2413522 + hypothetical protein gene gene2302 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02303 S101447_02304 S101447_02304 S101447_02304 2413535 2413810 + hypothetical protein gene gene2303 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02304 S101447_02305 S101447_02305 S101447_02305 2413797 2414369 - hypothetical protein gene gene2304 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02305 S101447_02306 S101447_02306 S101447_02306 2414571 2415074 + Protein YciF gene gene2305 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02306 S101447_02307 S101447_02307 S101447_02307 2415476 2416120 + hypothetical protein gene gene2306 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02307 S101447_02308 S101447_02308 inhA inhA 2416168 2417112 + Cyclohexyl-isocyanide hydratase Belongs to the peptidase C56 family%3B KEGG: bcen:DM39_2748 cyclohexyl-isocyanide hydratase gene gene2307 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02308 S101447_02309 S101447_02309 S101447_02309 2417109 2418038 - hypothetical protein gene gene2308 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02309 S101447_02310 S101447_02310 S101447_02310 2418192 2418656 - hypothetical protein gene gene2309 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02310 S101447_02311 S101447_02311 yahK yahK 2418907 2419977 + NADP-dependent alcohol dehydrogenase C Isopeptide bond%3B Metal-binding%3B NADP%3B Oxidoreductase%3B Ubl conjugation%3B Zinc%3B Prefers aldehydes over alcohols. Belongs to the zinc-containing alcohol dehydrogenase family%3B KEGG: goh:B932_2820 uncharacterized zinc-type alcohol dehydrogenase-like protein%3B Oxidoreductases gene gene2310 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02311 S101447_02312 S101447_02312 S101447_02312 2420077 2422611 - hypothetical protein gene gene2311 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02312 S101447_02313 S101447_02313 S101447_02313 2423067 2425961 - Platelet binding protein GspB Cell wall%3B Glycoprotein%3B Peptidoglycan-anchor%3B Secreted%3B Signal%3B Plays a role in virulence and host-pathogen interactions. Mediates binding to human platelets via interaction with the human cell surface glycoprotein GP1BA%3B Belongs to the SraP family gene gene2312 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02313 S101447_02314 S101447_02314 S101447_02314 2426210 2427154 + putative HTH-type transcriptional regulator YfeR DNA-binding%3B Transcription%3B Transcription regulation%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2313 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02314 S101447_02315 S101447_02315 S101447_02315 2427359 2428981 + Hemin import ATP-binding protein HmuV ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3. A. 1. 14. 5) family%3B Contains 1 ABC transporter domain gene gene2314 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02315 S101447_02316 S101447_02316 S101447_02316 2428920 2429021 + hypothetical protein gene gene2315 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02316 S101447_02317 S101447_02317 S101447_02317 2429381 2429764 + hypothetical protein gene gene2316 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02317 S101447_02318 S101447_02318 S101447_02318 2430043 2431176 + hypothetical protein gene gene2317 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02318 S101447_02319 S101447_02319 S101447_02319 2431173 2431904 + hypothetical protein gene gene2318 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02319 S101447_02320 S101447_02320 S101447_02320 2431901 2432533 + hypothetical protein gene gene2319 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02320 S101447_02321 S101447_02321 S101447_02321 2432403 2433539 - hypothetical protein gene gene2320 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02321 S101447_02322 S101447_02322 S101447_02322 2434266 2435957 + putative transporter Cell membrane%3B Membrane%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the AAE transporter (TC 2. A. 81) family%3B Contains 2 RCK C-terminal domains gene gene2321 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02322 S101447_02323 S101447_02323 S101447_02323 2435983 2437572 + Aspartate 4-decarboxylase Amino-acid biosynthesis%3B Aminotransferase%3B Decarboxylase%3B Lyase%3B Pyridoxal phosphate%3B Transferase%3B Bifunctional enzyme that has both L-aspartate decarboxylase and transaminase activity. Has high activity with L- aspartate%2C and much lower activity with D-aspartate%2C L-lysine and L-glutamine%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: apt:APA01_15490 aspartate 4-decarboxylase gene gene2322 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02323 S101447_02324 S101447_02324 ansA ansA 2437690 2438790 + Asparaginase Cytoplasm%3B Hydrolase%3B Phosphoprotein%3B Belongs to the asparaginase 1 family%3B Contains 1 asparaginase/glutaminase domain%3B KEGG: apt:APA01_15480 L-asparaginase gene gene2323 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02324 S101447_02325 S101447_02325 S101447_02325 2438820 2439809 + hypothetical protein gene gene2324 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02325 S101447_02326 S101447_02326 S101447_02326 2440066 2440824 + uncharacterized protein To E. coli YbeT gene gene2325 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02326 S101447_02327 S101447_02327 S101447_02327 2440980 2443418 + putative TonB-dependent receptor BfrD Cell outer membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Virulence%3B Probably involved in iron transport. Belongs to the TonB-dependent receptor family gene gene2326 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02327 S101447_02328 S101447_02328 S101447_02328 2443521 2444210 + PKHD-type hydroxylase Dioxygenase%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Vitamin C%3B Contains 1 Fe2OG dioxygenase domain%3B KEGG: bid:Bind_0236 PKHD-type hydroxylase%3B With 2-oxoglutarate as one donor%2C and incorporation of one atom each of oxygen into both donors gene gene2327 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02328 S101447_02329 S101447_02329 S101447_02329 2444877 2446571 + Transport ATP-binding protein AarD ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene2328 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02329 S101447_02330 S101447_02330 S101447_02330 2446568 2448259 + ATP-binding/permease protein CydD ATP-binding%3B Cell membrane%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system (By similarity)%3B Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3. A. 1. 129. 1) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene2329 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02330 S101447_02331 S101447_02331 S101447_02331 2448325 2449938 + Cytochrome bd-II ubiquinol oxidase subunit Cell inner membrane%3B Cell membrane%3B Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B Transport%3B A terminal oxidase that catalyzes quinol-dependent%2C Na(+)-independent oxygen uptake. Prefers menadiol over other quinols although ubiquinol was not tested (PubMed:8626304). Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O%2C transferring 1 proton/electron%3B Belongs to the cytochrome ubiquinol oxidase subunit 1 family%3B KEGG: apt:APA01_15390 cytochrome d ubiquinol oxidase subunit I%3B With oxygen as acceptor gene gene2330 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02331 S101447_02332 S101447_02332 S101447_02332 2449953 2451092 + Cytochrome bd-I ubiquinol oxidase subunit Cell inner membrane%3B Cell membrane%3B Electron transport%3B Formylation%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B Transport%3B A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E. coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O%2C transferring 1 proton/electron (By similarity)%3B Belongs to the cytochrome ubiquinol oxidase subunit 2 family%3B KEGG: apt:APA01_15380 cytochrome d ubiquinol oxidase subunit II%3B With oxygen as acceptor gene gene2331 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02332 S101447_02333 S101447_02333 S101447_02333 2451106 2451300 + hypothetical protein gene gene2332 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02333 S101447_02334 S101447_02334 S101447_02334 2451303 2451401 + hypothetical protein gene gene2333 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02334 S101447_02335 S101447_02335 S101447_02335 2451642 2452982 + L-sorbosone dehydrogenase Cell membrane%3B Membrane%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B Converts L-sorbosone into 2-keto-L-gulonic acid (2KGA). To B. burgdorferi BB024%3B KEGG: reh:H16_B0572 null%3B With NAD(+) or NADP(+) as acceptor gene gene2334 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02335 S101447_02336 S101447_02336 S101447_02336 2453400 2454212 + Small-conductance mechanosensitive channel Cell inner membrane%3B Cell membrane%3B Ion channel%3B Ion transport%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1. 0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage (By similarity)%3B Belongs to the MscS (TC 1. A. 23) family gene gene2335 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02336 S101447_02337 S101447_02337 S101447_02337 2454414 2456690 + Ferrichrome receptor FcuA Cell outer membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Receptor for the hydroxamate siderophore%2C ferrichrome. Binds also to most other ferrichrome derivatives except enantio ferrichrome and ferric rhodotorulate. Belongs to the TonB-dependent receptor family gene gene2336 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02337 S101447_02338 S101447_02338 S101447_02338 2456972 2457493 + hypothetical protein gene gene2337 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02338 S101447_02339 S101447_02339 S101447_02339 2457866 2459443 + Hopanoid C-2 methylase Iron%3B Iron-sulfur%3B Metal-binding%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Required for methylation of hopanoids at the C-2 position%3B Belongs to the radical SAM superfamily%3B Contains 1 B12-binding domain gene gene2338 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02339 S101447_02340 S101447_02340 S101447_02340 2459465 2461090 - Outer membrane protein TolC Antibiotic resistance%3B Cell outer membrane%3B Membrane%3B Repeat%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Outer membrane channel%2C which is required for the function of several efflux systems such as AcrAB-TolC%2C AcrEF-TolC%2C EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells%3B Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene2339 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02340 S101447_02341 S101447_02341 S101447_02341 2461087 2462928 - Multidrug resistance protein MdtO Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Could be involved in resistance to puromycin%2C acriflavine and tetraphenylarsonium chloride%3B Belongs to the MdtO family gene gene2340 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02341 S101447_02342 S101447_02342 S101447_02342 2462894 2463943 - Multidrug resistance protein MdtN Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Signal-anchor%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Could be involved in resistance to puromycin%2C acriflavine and tetraphenylarsonium chloride%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene2341 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02342 S101447_02343 S101447_02343 S101447_02343 2463943 2464221 - hypothetical protein gene gene2342 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02343 S101447_02344 S101447_02344 S101447_02344 2464622 2466982 - hypothetical protein gene gene2343 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02344 S101447_02345 S101447_02345 S101447_02345 2467282 2467872 + Transcriptional regulator YqjI DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Represses the expression of YqjH which is involved in iron homeostasis under excess nickel conditions. Also represses its own expression gene gene2344 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02345 S101447_02346 S101447_02346 S101447_02346 2467909 2468526 + Caffeoyl-CoA O-methyltransferase KEGG: kfl:Kfla_2654 caffeoyl-CoA O-methyltransferase gene gene2345 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02346 S101447_02347 S101447_02347 yqjH yqjH 2468556 2469335 + Ferric-chelate reductase (NADPH) Cytoplasm%3B FAD%3B Flavoprotein%3B NADP%3B Oxidoreductase%3B Plays a role in iron homeostasis under excess nickel conditions%3B Belongs to the SIP oxidoreductase family%3B Contains 1 FAD-binding FR-type domain%3B KEGG: ent:Ent638_3524 ferric-chelate reductase (NADPH) gene gene2346 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02347 S101447_02348 S101447_02348 S101447_02348 2469438 2470946 + Multidrug resistance protein Antibiotic resistance%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Confers resistance to puromycin%2C tosufloxacin and norfloxacin%3B Belongs to the major facilitator superfamily. EmrB family gene gene2347 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02348 S101447_02349 S101447_02349 S101447_02349 2471000 2472607 - Feruloyl esterase Belongs to the tannase family%3B KEGG: apt:APA01_15220 feruloyl esterase gene gene2348 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02349 S101447_02350 S101447_02350 S101447_02350 2472808 2474004 + hypothetical protein gene gene2349 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02350 S101447_02351 S101447_02351 S101447_02351 2474028 2474546 + hypothetical protein gene gene2350 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02351 S101447_02352 S101447_02352 S101447_02352 2474633 2477074 - hypothetical protein gene gene2351 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02352 S101447_02353 S101447_02353 plcC plcC 2477348 2479828 - Phospholipase C Cell membrane%3B Hydrolase%3B Membrane%3B Signal%3B Virulence%3B Hydrolyzes sphingomyelin in addition to phosphatidylcholine. Probable virulence factor implicated in the pathogenesis of M. tuberculosis at the level of intracellular survival%2C by the alteration of cell signaling events or by direct cytotoxicity (By similarity)%3B Belongs to the bacterial phospholipase C family%3B KEGG: gox:GOX2176 phospholipase C gene gene2352 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02353 S101447_02354 S101447_02354 S101447_02354 2479859 2480974 - Purine nucleoside permease Signal%3B Transport%3B Nucleoside permease that transports adenosine and guanosine. Does not show any transport activities towards cytidine%2C adenine%2C guanine%2C uridine%2C and uracil%3B Belongs to the NUP family gene gene2353 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02354 S101447_02355 S101447_02355 S101447_02355 2480976 2481806 - Enterobacter ribonuclease KEGG: apt:APA01_15160 ribonuclease I (enterobacter ribonuclease) gene gene2354 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02355 S101447_02356 S101447_02356 phoN phoN 2481843 2482616 - Acid phosphatase Hydrolase%3B Magnesium%3B Periplasm%3B Signal%3B Belongs to the class A bacterial acid phosphatase family%3B KEGG: apt:APA01_15150 acid phosphatase (class A) gene gene2355 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02356 S101447_02357 S101447_02357 ncd2 ncd2 2482763 2483857 + Nitronate monooxygenase Flavoprotein%3B FMN%3B Monooxygenase%3B Oxidoreductase%3B Catalyzes the oxidation of alkyl nitronates to produce the corresponding carbonyl compounds and nitrites%3B Belongs to the nitronate monooxygenase family%3B KEGG: bra:BRADO4492 nitronate monooxygenase gene gene2356 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02357 S101447_02358 S101447_02358 S101447_02358 2483852 2484832 - Macrolide export ATP-binding/permease protein MacB Antibiotic resistance%3B ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD)%2C which form a pore in the inner membrane%2C and an ATP-binding domain (NBD)%2C which is responsible for energy generation. Confers resistance against macrolides%3B Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3. A. 1. 122) family%3B Contains 1 ABC transporter domain gene gene2357 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02358 S101447_02359 S101447_02359 S101447_02359 2484829 2485872 - Oligopeptide transport ATP-binding protein ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Nucleotide-binding%3B Peptide transport%3B Protein transport%3B Transport%3B Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene2358 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02359 S101447_02360 S101447_02360 S101447_02360 2485862 2486836 - Putative peptide transport system permease protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene2359 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02360 S101447_02361 S101447_02361 S101447_02361 2486849 2487868 - Inner membrane ABC transporter permease protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2360 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02361 S101447_02362 S101447_02362 S101447_02362 2487865 2489526 - hypothetical protein gene gene2361 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02362 S101447_02363 S101447_02363 S101447_02363 2489740 2491218 + IMP dehydrogenase CBS domain%3B GMP biosynthesis%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Potassium%3B Purine biosynthesis%3B Repeat%3B Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP)%2C the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides%2C and therefore plays an important role in the regulation of cell growth%3B Belongs to the IMPDH/GMPR family%3B Contains 2 CBS domains%3B KEGG: apt:APA01_15080 IMP dehydrogenase gene gene2362 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02363 S101447_02364 S101447_02364 S101447_02364 2491228 2492541 + 16S rRNA (cytosine(967)-C(5))-methyltransferase Cytoplasm%3B Methyltransferase%3B Ribosome biogenesis%3B RNA-binding%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family%3B KEGG: gbe:GbCGDNIH1_1148 16S rRNA (cytosine967-C5)-methyltransferase gene gene2363 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02364 S101447_02365 S101447_02365 S101447_02365 2492637 2494469 + K(+)/H(+) antiporter NhaP2 Antiport%3B Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Potassium%3B Potassium transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels%3B Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2. A. 36) family. NhaP2 subfamily%3B Contains 1 RCK C-terminal domain gene gene2364 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02365 S101447_02366 S101447_02366 S101447_02366 2494466 2494981 - hypothetical protein gene gene2365 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02366 S101447_02367 S101447_02367 S101447_02367 2495128 2495850 + Response regulator MprA Cytoplasm%3B DNA-binding%3B Phosphoprotein%3B Stress response%3B Transcription%3B Transcription regulation%3B Two-component regulatory system%3B Virulence%3B Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2366 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02367 S101447_02368 S101447_02368 S101447_02368 2496520 2496594 - tRNA-Val tRNA gene2367 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02368 S101447_02369 S101447_02369 S101447_02369 2496717 2497448 + hypothetical protein gene gene2368 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02369 S101447_02370 S101447_02370 warS warS 2497462 2498457 - Tryptophan--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Ligase%3B Mitochondrion%3B Nucleotide-binding%3B Protein biosynthesis%3B Transit peptide%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: hms:HMU09600 tryptophanyl-tRNA synthetase gene gene2369 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02370 S101447_02371 S101447_02371 S101447_02371 2498491 2498997 - Cytochrome c-552 Electron transport%3B Heme%3B Iron%3B Metal-binding%3B Pyrrolidone carboxylic acid%3B Signal%3B Transport. gene gene2370 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02371 S101447_02372 S101447_02372 fklB fklB 2499015 2499512 - Peptidylprolyl isomerase Endoplasmic reticulum%3B Isomerase%3B Rotamase%3B Signal%3B PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)%3B Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: apt:APA01_14990 FKBP-type peptidyl-prolyl cis-trans isomerase FklB gene gene2371 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02372 S101447_02373 S101447_02373 argG argG 2499557 2500798 - Argininosuccinate synthase Amino-acid biosynthesis%3B Arginine biosynthesis%3B ATP-binding%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Belongs to the argininosuccinate synthase family. Type 1 subfamily%3B KEGG: apt:APA01_14980 argininosuccinate synthase gene gene2372 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02373 S101447_02374 S101447_02374 rlmN rlmN 2500909 2502135 - 23S rRNA (adenine(2503)-C(2))-methyltransferase 4Fe-4S%3B Cytoplasm%3B Disulfide bond%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B tRNA processing%3B Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity%3B Belongs to the radical SAM superfamily. RlmN family%3B KEGG: apt:APA01_14970 23S rRNA (adenine2503-C2)-methyltransferase gene gene2373 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02374 S101447_02375 S101447_02375 S101447_02375 2502257 2502838 - hypothetical protein gene gene2374 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02375 S101447_02376 S101447_02376 tlyA tlyA 2502976 2503713 - 23S rRNA (cytidine(1920)-2'-O)-methyltransferase Methyltransferase%3B RNA-binding%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Belongs to the TlyA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: dol:Dole_1661 23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase gene gene2375 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02376 S101447_02377 S101447_02377 S101447_02377 2503720 2505708 - 1-deoxy-D-xylulose-5-phosphate synthase Isoprene biosynthesis%3B Magnesium%3B Metal-binding%3B Thiamine biosynthesis%3B Thiamine pyrophosphate%3B Transferase%3B Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)%3B Belongs to the transketolase family. DXPS subfamily%3B KEGG: apt:APA01_14940 1-deoxy-D-xylulose-5-phosphate synthase gene gene2376 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02377 S101447_02378 S101447_02378 ispA ispA 2505713 2506645 - Dimethylallyltranstransferase Cytoplasm%3B Isoprene biosynthesis%3B Magnesium%3B Metal-binding%3B Transferase%3B Belongs to the FPP/GGPP synthase family%3B KEGG: apt:APA01_14930 farnesyl diphosphate synthase gene gene2377 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02378 S101447_02379 S101447_02379 xseB xseB 2506653 2506883 - Exodeoxyribonuclease VII Cytoplasm%3B Exonuclease%3B Hydrolase%3B Nuclease%3B Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides%2C which are then degraded further into small acid-soluble oligonucleotides%3B Belongs to the XseB family%3B KEGG: apt:APA01_14920 exodeoxyribonuclease VII small subunit gene gene2378 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02379 S101447_02380 S101447_02380 tusA tusA 2506979 2507230 - UPF0033 protein YrkI Belongs to the UPF0033 family%3B KEGG: afe:Lferr_2187 tRNA 2-thiouridine synthesizing protein A%3B Sulfurtransferases gene gene2379 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02380 S101447_02381 S101447_02381 scrK scrK 2507346 2508239 + Fructokinase ATP-binding%3B Carbohydrate metabolism%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Catalyzes the phosphorylation of fructose to fructose-6- P. Has also low level glucokinase activity in vitro. Is not able to phosphorylate D-ribose%2C D-mannitol%2C D-sorbitol%2C inositol%2C and L-threonine%3B Belongs to the ROK (NagC/XylR) family%3B KEGG: goh:B932_2103 fructokinase gene gene2380 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02381 S101447_02382 S101447_02382 rlmE rlmE 2508264 2509055 - 23S rRNA (uridine(2552)-2'-O)-methyltransferase Cytoplasm%3B Methyltransferase%3B rRNA processing%3B S-adenosyl-L-methionine%3B Transferase%3B Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family%3B KEGG: apt:APA01_14890 23S rRNA (uridine2552-2'-O)-methyltransferase gene gene2381 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02382 S101447_02383 S101447_02383 S101447_02383 2509052 2510176 - Exopolyphosphatase Hydrolase%3B Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response'%2C an adaptive process that allows bacteria to respond to amino acid starvation%2C resulting in the coordinated regulation of numerous cellular activities (By similarity)%3B Belongs to the GppA/Ppx family. GppA subfamily%3B KEGG: apt:APA01_14880 exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase gene gene2382 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02383 S101447_02384 S101447_02384 S101447_02384 2510370 2510443 + tRNA-Gln tRNA gene2383 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02384 S101447_02385 S101447_02385 fdoG fdoG 2510814 2513867 + Formate dehydrogenase 4Fe-4S%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Molybdenum%3B NAD%3B Oxidoreductase%3B Periplasm%3B Selenocysteine%3B Signal%3B Formate dehydrogenase allows E. coli to use formate as major electron donor during anaerobic respiration%2C when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI)%2C through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force%2C together with the dissimilatory nitrate reductase (Nar)%3B Belongs to the prokaryotic molybdopterin-containing oxidoreductase family%3B Contains 1 4Fe-4S Mo/W bis-MGD-type domain%3B KEGG: apt:APA01_14860 formate dehydrogenase major subunit gene gene2384 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02385 S101447_02386 S101447_02386 S101447_02386 2513877 2514812 + Formate dehydrogenase%2C nitrate-inducible%2C iron-sulfur subunit 4Fe-4S%3B Cell inner membrane%3B Cell membrane%3B Electron transport%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Formate dehydrogenase allows E. coli to use formate as major electron donor during anaerobic respiration%2C when nitrate is used as electron acceptor. The beta subunit FdnH is an electron transfer unit containing 4 iron-sulfur cluster%3B it serves as a conduit for electrons that are transferred from the formate oxidation site in the alpha subunit (FdnG) to the menaquinone associated with the gamma subunit (FdnI) of formate dehydrogenase- N. Formate dehydrogenase-N is part of a system that generates proton motive force%2C together with the dissimilatory nitrate reductase (Nar)%3B Contains 4 4Fe-4S ferredoxin-type domains gene gene2385 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02386 S101447_02387 S101447_02387 S101447_02387 2514812 2515465 + Formate dehydrogenase%2C nitrate-inducible%2C cytochrome b556(Fdn) subunit Cell inner membrane%3B Cell membrane%3B Electron transport%3B Heme%3B Iron%3B Membrane%3B Metal-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Formate dehydrogenase allows the bacterium to use formate as major electron donor during anaerobic respiration%2C when nitrate is used as electron acceptor. Subunit gamma is the cytochrome b556 component of the formate dehydrogenase-N%2C and also contains a menaquinone reduction site that receives electrons from the beta subunit (FdnH)%2C through its hemes. Formate dehydrogenase- N is part of a system that generates proton motive force%2C together with the dissimilatory nitrate reductase (Nar) (By similarity)%3B Belongs to the formate dehydrogenase gamma subunit family gene gene2386 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02387 S101447_02388 S101447_02388 S101447_02388 2515465 2516385 + Protein FdhE like protein Cytoplasm%3B Necessary for formate dehydrogenase activity%3B Belongs to the FdhE family gene gene2387 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02388 S101447_02389 S101447_02389 S101447_02389 2516393 2517652 + Molybdopterin molybdotransferase ATP-binding%3B Cell membrane%3B Cytoplasm%3B Cytoskeleton%3B Magnesium%3B Membrane%3B Metal-binding%3B Molybdenum%3B Molybdenum cofactor biosynthesis%3B Multifunctional enzyme%3B Nucleotide-binding%3B Transferase%3B Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. Involved in molybdenum cofactor biosynthesis. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step%2C molybdopterin is adenylated. Subsequently%2C molybdate is inserted into adenylated molybdopterin and AMP is released (By similarity)%3B In the N-terminal sectio%3B belongs to the MoaB/Mog family%3B In the C-terminal sectio%3B belongs to the MoeA family%3B KEGG: apt:APA01_14820 molybdopterin molybdotransferase gene gene2388 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02389 S101447_02390 S101447_02390 S101447_02390 2517649 2518182 - Molybdopterin-guanine dinucleotide biosynthesis adapter protein GTP-binding%3B Molybdenum cofactor biosynthesis%3B Nucleotide-binding%3B GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor%2C and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity (By similarity)%3B Belongs to the MobB family gene gene2389 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02390 S101447_02391 S101447_02391 mobA mobA 2518292 2518921 + Molybdenum cofactor guanylyltransferase Cytoplasm%3B GTP-binding%3B Magnesium%3B Metal-binding%3B Molybdenum cofactor biosynthesis%3B Nucleotide-binding%3B Transferase%3B Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor%3B Belongs to the MobA family%3B KEGG: cja:CJA_1340 molybdopterin-guanine dinucleotide biosynthesis protein A gene gene2390 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02391 S101447_02392 S101447_02392 S101447_02392 2518921 2519745 + Protein FdhD like protein Cytoplasm%3B Necessary for formate dehydrogenase activity%3B Belongs to the FdhD family gene gene2391 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02392 S101447_02393 S101447_02393 S101447_02393 2519786 2520397 - Glutathione transferase Cytoplasm%3B Transferase%3B Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles%3B Belongs to the GST superfamily. Beta family%3B Contains 1 GST C-terminal domain%3B Contains 1 GST N-terminal domain%3B KEGG: scl:sce3993 glutathione S-transferase gene gene2392 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02393 S101447_02394 S101447_02394 S101447_02394 2520763 2521353 + Putative manganese efflux pump MntP Cell membrane%3B Ion transport%3B Manganese%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Probably functions as a manganese efflux pump%3B Belongs to the MntP (TC 9. B. 29) family gene gene2393 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02394 S101447_02395 S101447_02395 S101447_02395 2521363 2522037 - hypothetical protein gene gene2394 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02395 S101447_02396 S101447_02396 S101447_02396 2523024 2524721 + Formate dehydrogenase 3Fe-4S%3B Amino-acid biosynthesis%3B Amyloplast%3B FAD%3B Flavoprotein%3B FMN%3B Glutamate biosynthesis%3B Glutamine amidotransferase%3B Iron%3B Iron-sulfur%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Plastid%3B Transit peptide%3B Required for the assimilation of symbiotically fixed nitrogen into amino acids in root nodules%3B Belongs to the glutamate synthase family%3B Contains 1 glutamine amidotransferase type-2 domain%3B KEGG: vfu:vfu_A02711 formate dehydrogenase major subunit gene gene2395 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02396 S101447_02397 S101447_02397 nifJ nifJ 2524735 2528310 + Pyruvate-flavodoxin oxidoreductase 4Fe-4S%3B Electron transport%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Nitrogen fixation%3B Oxidoreductase%3B Plasmid%3B Repeat%3B Transport%3B Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin%2C which reduces nitrogenase. Belongs to the NifJ family%3B Contains 2 4Fe-4S ferredoxin-type domains%3B KEGG: apt:APA01_14730 pyruvate-ferredoxin/flavodoxin oxidoreductase%3B Pyruvate synthase gene gene2396 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02397 S101447_02398 S101447_02398 S101447_02398 2528334 2529338 + Dihydroorotate oxidase (fumarate) KEGG: alv:Alvin_0263 dihydroorotate dehydrogenase (fumarate) gene gene2397 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02398 S101447_02399 S101447_02399 S101447_02399 2529347 2530363 + Phosphate acetyltransferase Acyltransferase%3B Cytoplasm%3B Transferase%3B Belongs to the phosphate acetyltransferase and butyryltransferase family%3B KEGG: apt:APA01_14710 phosphate acetyltransferase gene gene2398 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02399 S101447_02400 S101447_02400 ackA ackA 2530393 2531595 + Acetate kinase ATP-binding%3B Cytoplasm%3B Kinase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Transferase%3B Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction%3B Belongs to the acetokinase family%3B KEGG: apt:APA01_14700 acetate kinase gene gene2399 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02400 S101447_02401 S101447_02401 S101447_02401 2531696 2533570 + hypothetical protein gene gene2400 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02401 S101447_02402 S101447_02402 S101447_02402 2533570 2534652 + UPF0118 inner membrane protein YdiK Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0118 (PerM) family gene gene2401 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02402 S101447_02403 S101447_02403 S101447_02403 2534725 2535102 - hypothetical protein gene gene2402 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02403 S101447_02404 S101447_02404 S101447_02404 2535725 2536021 + hypothetical protein gene gene2403 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02404 S101447_02405 S101447_02405 S101447_02405 2536018 2537469 + hypothetical protein gene gene2404 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02405 S101447_02406 S101447_02406 S101447_02406 2537563 2538756 - K(+)/H(+) antiporter Antiport%3B Ion transport%3B Membrane%3B Phosphoprotein%3B Potassium%3B Potassium transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Potassium-proton antiport. Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2. A. 37) family gene gene2405 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02406 S101447_02407 S101447_02407 S101447_02407 2539346 2540842 + hypothetical protein gene gene2406 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02407 S101447_02408 S101447_02408 S101447_02408 2541184 2543640 + Quinoprotein glucose dehydrogenase (PQQ%2C quinone) Cell inner membrane%3B Cell membrane%3B Membrane%3B Oxidoreductase%3B PQQ%3B Signal%3B Transmembrane%3B Transmembrane helix%3B Catalyzes an exceptionally high rate of oxidation of a wide range of aldose sugars%2C including D-glucose%2C galactose%2C arabinose and xylose%2C and also the disaccharides lactose%2C cellobiose and maltose. Belongs to the bacterial PQQ dehydrogenase family%3B KEGG: apt:APA01_14620 quinoprotein glucose dehydrogenase gene gene2407 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02408 S101447_02409 S101447_02409 S101447_02409 2543728 2544621 + hypothetical protein gene gene2408 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02409 S101447_02410 S101447_02410 S101447_02410 2544778 2545713 + Acetoin catabolism regulatory protein Acetoin catabolism%3B Activator%3B ATP-binding%3B DNA-binding%3B Nucleotide-binding%3B Transcription%3B Transcription regulation%3B Two-component regulatory system%3B Required for sigma-54-dependent transcription of acoXABC. Contains 1 sigma-54 factor interaction domain gene gene2409 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02410 S101447_02411 S101447_02411 S101447_02411 2545719 2547653 - hypothetical protein gene gene2410 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02411 S101447_02412 S101447_02412 fumC fumC 2547981 2549429 + Fumarate hydratase Allosteric enzyme%3B Cytoplasm%3B Lyase%3B Tricarboxylic acid cycle%3B Catalyzes the reversible addition of water to fumarate to give L-malate%3B Belongs to the class-II fumarase/aspartase family. Fumarase subfamily%3B KEGG: apt:APA01_14580 fumarate hydratase%2C class II gene gene2411 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02412 S101447_02413 S101447_02413 S101447_02413 2549481 2550020 - hypothetical protein gene gene2412 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02413 S101447_02414 S101447_02414 cobG cobG 2550191 2551423 + Precorrin-3B synthase 4Fe-4S%3B Cobalamin biosynthesis%3B Heme%3B Iron%3B Iron-sulfur%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Porphyrin biosynthesis%3B Catalyzes the elimination of C-20 in precorrin-3A to form precorrin-3B. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family%3B KEGG: apt:APA01_14560 precorrin-3B synthase gene gene2413 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02414 S101447_02415 S101447_02415 S101447_02415 2551410 2552039 + Precorrin-8X methylmutase Cobalamin biosynthesis%3B Isomerase%3B Catalyzes the conversion of precorrin-8X to hydrogenobyrinate%3B Belongs to the CobH/CbiC family%3B KEGG: mam:Mesau_03549 precorrin-8X/cobalt-precorrin-8 methylmutase gene gene2414 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02415 S101447_02416 S101447_02416 S101447_02416 2552040 2552765 + Precorrin-2 C(20)-methyltransferase Cobalamin biosynthesis%3B Methyltransferase%3B Multifunctional enzyme%3B S-adenosyl-L-methionine%3B Transferase%3B Methylates precorrin-2 at the C-20 position to produce precorrin-3A%3B Belongs to the precorrin methyltransferase family%3B KEGG: apt:APA01_14540 precorrin-2/cobalt-factor-2 C20-methyltransferase gene gene2415 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02416 S101447_02417 S101447_02417 cobJ cobJ 2552762 2553520 + Precorrin-3B C(17)-methyltransferase Cobalamin biosynthesis%3B Methyltransferase%3B Multifunctional enzyme%3B S-adenosyl-L-methionine%3B Transferase%3B Methylates precorrin-2 at the C-20 position to produce precorrin-3A%3B Belongs to the precorrin methyltransferase family%3B KEGG: smd:Smed_2815 precorrin-3B C17-methyltransferase gene gene2416 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02417 S101447_02418 S101447_02418 S101447_02418 2553490 2554293 - Precorrin-6A reductase Cobalamin biosynthesis%3B NADP%3B Oxidoreductase%3B Catalyzes the reduction of the macrocycle of precorrin- 6X into precorrin-6Y. Belongs to the precorrin-6x reductase family%3B KEGG: apt:APA01_14520 precorrin-6A/cobalt-precorrin-6A reductase gene gene2417 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02418 S101447_02419 S101447_02419 cobL cobL 2554382 2555626 + Precorrin-6B C(5%2C15)-methyltransferase (decarboxylating) Cobalamin biosynthesis%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Catalyzes the methylation of both C-5 and C-15 in precorrin-6Y to form precorrin-8X. Belongs to the precorrin methyltransferase family%3B KEGG: apt:APA01_14510 precorrin-6Y C5%2C15-methyltransferase (decarboxylating) gene gene2418 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02419 S101447_02420 S101447_02420 cbiG cbiG 2555623 2555997 + Cobalt-precorrin 5A hydrolase KEGG: apt:APA01_14500 cobalt-precorrin 5A hydrolase gene gene2419 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02420 S101447_02421 S101447_02421 cobM cobM 2555998 2556756 + Precorrin-4 C(11)-methyltransferase Cobalamin biosynthesis%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. Belongs to the precorrin methyltransferase family%3B KEGG: spoi:IMCC21906_00669 precorrin-4/cobalt-precorrin-4 C11-methyltransferase gene gene2420 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02421 S101447_02422 S101447_02422 cbiD cbiD 2556761 2557753 - Cobalt-precorrin-5B (C(1))-methyltransferase Cobalamin biosynthesis%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A%3B Belongs to the CbiD family%3B KEGG: apt:APA01_14480 cobalt-precorrin-5B (C1)-methyltransferase gene gene2421 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02422 S101447_02423 S101447_02423 S101447_02423 2557936 2559291 - Alpha-ketoglutarate permease Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family. CsbX subfamily gene gene2422 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02423 S101447_02424 S101447_02424 S101447_02424 2559983 2560627 - Glutaredoxin-2 Disulfide bond%3B Electron transport%3B Redox-active center%3B Transport%3B Involved in reducing some disulfides in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase (By similarity)%3B Belongs to the glutaredoxin family%3B Contains 1 GST N-terminal domain gene gene2423 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02424 S101447_02425 S101447_02425 tpmT tpmT 2560752 2561393 + Thiopurine S-methyltransferase Cytoplasm%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family%3B KEGG: apt:APA01_14450 thiopurine S-methyltransferase gene gene2424 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02425 S101447_02426 S101447_02426 S101447_02426 2561566 2562822 + C4-dicarboxylate transport protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Plasmid%3B Sugar transport%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Responsible for the transport of dicarboxylates such as succinate%2C fumarate%2C and malate from the periplasm across the membrane%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene2425 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02426 S101447_02427 S101447_02427 S101447_02427 2562944 2565457 + UvrABC system protein ATP-binding%3B Cytoplasm%3B DNA damage%3B DNA excision%3B DNA repair%3B DNA-binding%3B Excision nuclease%3B Metal-binding%3B Nucleotide-binding%3B Repeat%3B SOS response%3B Zinc%3B Zinc-finger%3B The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB%2C the UvrA molecules dissociate%3B Belongs to the ABC transporter superfamily. UvrA family%3B Contains 2 ABC transporter domains gene gene2426 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02427 S101447_02428 S101447_02428 S101447_02428 2565820 2567307 + 16S ribosomal RNA rRNA gene2427 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02428 S101447_02429 S101447_02429 S101447_02429 2567523 2567599 + tRNA-Ile tRNA gene2428 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02429 S101447_02430 S101447_02430 S101447_02430 2567624 2567699 + tRNA-Ala tRNA gene2429 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02430 S101447_02431 S101447_02431 S101447_02431 2568031 2570773 + 23S ribosomal RNA rRNA gene2430 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02431 S101447_02432 S101447_02432 S101447_02432 2570882 2570997 + 5S ribosomal RNA rRNA gene2431 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02432 S101447_02433 S101447_02433 S101447_02433 2571053 2571129 + tRNA-Met tRNA gene2432 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02433 S101447_02434 S101447_02434 S101447_02434 2571384 2573561 + Exodeoxyribonuclease V ATP-binding%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B DNA-dependent ATPase (ssDNA better than dsDNA) and ATP- dependent 5'-3' DNA helicase. Appears to move along DNA in single base steps%2C powered by hydrolysis of 1 molecule of ATP. Has low processivit%3B short (20 bp) substrates with 5'-overhangs or forked ends are the best substrates%2C is much less efficient on 52 or 76 bp substrates with 5'- overhangs. The presence of single-stranded DNA-binding protein (SSB) increases unwinding 4-5 fold. Has no activity on blunt DNA or DNA with 3'-overhangs. Requires at least 10 bases of 5'-ssDNA for helicase activity%3B Belongs to the RecD family. RecD-like subfamily%3B KEGG: gxl:H845_53 exodeoxyribonuclease V alpha subunit gene gene2433 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02434 S101447_02435 S101447_02435 S101447_02435 2574074 2574280 + hypothetical protein gene gene2434 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02435 S101447_02436 S101447_02436 S101447_02436 2574246 2574386 + hypothetical protein gene gene2435 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02436 S101447_02437 S101447_02437 hsdR hsdR 2574386 2577142 + Type I site-specific deoxyribonuclease ATP-binding%3B Coiled coil%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Restriction system%3B The EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'. Subunit R is required for both nuclease and ATPase activities%2C but not for modification. Belongs to the HsdR family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: mtt:Ftrac_0236 type I restriction enzyme%2C R subunit%3B overlaps another CDS with the same product name gene gene2436 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02437 S101447_02438 S101447_02438 hsdS hsdS 2577139 2578665 + Type I site-specific deoxyribonuclease DNA-binding%3B Restriction system%3B The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease%2C binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified%2C the DNA is cut. When the target site is hemimethylated%2C the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. Subunit S dictates DNA sequences specificity. The EcoBI enzyme recognizes 5'- TGAN(8)TGCT-3'. Belongs to the type-I restriction system S methylase family%3B KEGG: cpas:Clopa_1786 type I restriction enzyme%2C S subunit%3B overlaps another CDS with the same product name gene gene2437 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02438 S101447_02439 S101447_02439 hsdM hsdM 2578662 2580158 + Site-specific DNA-methyltransferase (adenine-specific) Methyltransferase%3B Restriction system%3B S-adenosyl-L-methionine%3B Transferase%3B Methylation of specific adenine residue%3B required for both restriction and modification activities%3B Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: adi:B5T_03110 type I restriction enzyme M protein gene gene2438 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02439 S101447_02440 S101447_02440 S101447_02440 2580242 2580403 + hypothetical protein gene gene2439 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02440 S101447_02441 S101447_02441 S101447_02441 2580601 2582679 + uncharacterized protein Plasmid%3B Belongs to the ParB family gene gene2440 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02441 S101447_02442 S101447_02442 S101447_02442 2582818 2584020 + hypothetical protein gene gene2441 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02442 S101447_02443 S101447_02443 S101447_02443 2584104 2584544 + hypothetical protein gene gene2442 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02443 S101447_02444 S101447_02444 S101447_02444 2584531 2585592 + hypothetical protein gene gene2443 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02444 S101447_02445 S101447_02445 S101447_02445 2585905 2586840 + hypothetical protein gene gene2444 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02445 S101447_02446 S101447_02446 S101447_02446 2587206 2587535 + Insertion element IS629 uncharacterized 12 kDa protein Transposable element%3B Belongs to the transposase 8 family gene gene2445 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02446 S101447_02447 S101447_02447 S101447_02447 2587532 2588437 + Transposase for insertion sequence element IS3411 DNA recombination%3B DNA-binding%3B Transposable element%3B Transposition%3B Involved in the transposition of the insertion sequence. Contains 1 integrase catalytic domain gene gene2446 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02447 S101447_02448 S101447_02448 S101447_02448 2588651 2589085 + hypothetical protein gene gene2447 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02448 S101447_02449 S101447_02449 S101447_02449 2589171 2589371 + hypothetical protein gene gene2448 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02449 S101447_02450 S101447_02450 S101447_02450 2589523 2590260 - hypothetical protein gene gene2449 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02450 S101447_02451 S101447_02451 S101447_02451 2590263 2593559 - Type I site-specific deoxyribonuclease To M. jannaschii MJ1214%3B KEGG: gox:GOX2567 type I restriction enzyme%2C R subunit gene gene2450 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02451 S101447_02452 S101447_02452 S101447_02452 2593589 2594779 - Type I site-specific deoxyribonuclease DNA-binding%3B Restriction system%3B The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease%2C binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified%2C the DNA is cut. When the target site is hemimethylated%2C the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. Subunit S dictates DNA sequences specificity. The EcoDI enzyme recognizes 5'- TTAN(7)GTCY-3'. Belongs to the type-I restriction system S methylase family%3B KEGG: xcv:XCV0510 type I restriction enzyme%2C S subunit gene gene2451 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02452 S101447_02453 S101447_02453 S101447_02453 2594769 2596295 - Site-specific DNA-methyltransferase (adenine-specific) Methyltransferase%3B Plasmid%3B Restriction system%3B S-adenosyl-L-methionine%3B Transferase%3B Methylation of specific adenine residue%3B required for both restriction and modification activities (By similarity). The EcoR124/3 I enzyme recognizes 5'-GAAN(7)RTCG-3'%3B Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: afi:Acife_0165 type I restriction enzyme M protein gene gene2452 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02453 S101447_02454 S101447_02454 S101447_02454 2596331 2596927 - hypothetical protein gene gene2453 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02454 S101447_02455 S101447_02455 S101447_02455 2597178 2597801 - hypothetical protein gene gene2454 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02455 S101447_02456 S101447_02456 S101447_02456 2598071 2599474 + putative HTH-type transcriptional regulator Aminotransferase%3B DNA-binding%3B Pyridoxal phosphate%3B Transcription%3B Transcription regulation%3B Transferase%3B In the C-terminal sectio%3B belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B Contains 1 HTH gntR-type DNA-binding domain gene gene2455 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02456 S101447_02457 S101447_02457 S101447_02457 2599816 2600298 + hypothetical protein gene gene2456 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02457 S101447_02458 S101447_02458 S101447_02458 2600323 2601306 + Aliphatic nitrilase Hydrolase%3B Nitrilase that acts mostly on arylacetonitriles. Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family%3B Contains 1 CN hydrolase domain%3B KEGG: goh:B932_3190 aliphatic nitrilase gene gene2457 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02458 S101447_02459 S101447_02459 S101447_02459 2601303 2602412 + Biotin synthase KEGG: sai:Saci_0343 biotin synthase gene gene2458 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02459 S101447_02460 S101447_02460 S101447_02460 2602409 2602972 + hypothetical protein gene gene2459 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02460 S101447_02461 S101447_02461 S101447_02461 2602972 2603940 + uncharacterized protein To M. jannaschii MJ0640 and MJ0799 gene gene2460 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02461 S101447_02462 S101447_02462 S101447_02462 2603937 2605118 + Mannosylfructose-phosphate synthase Glycosyltransferase%3B Transferase%3B Belongs to the glycosyltransferase 1 family%3B KEGG: atu:Atu0661 mannosylfructose-phosphate synthase gene gene2461 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02462 S101447_02463 S101447_02463 S101447_02463 2605106 2605393 + hypothetical protein gene gene2462 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02463 S101447_02464 S101447_02464 S101447_02464 2605410 2606657 + putative oxidoreductase CzcO Cadmium%3B Cell membrane%3B Cobalt%3B Cobalt transport%3B Ion transport%3B Membrane%3B Oxidoreductase%3B Potassium%3B Potassium transport%3B Transport%3B Zinc%3B Zinc transport%3B Involved in potassium and divalent cation transport. Enhances the transport activity of the cation/potassium transporter CzcD gene gene2463 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02464 S101447_02465 S101447_02465 prpE prpE 2606672 2608444 + Propionate--CoA ligase Acetylation%3B ATP-binding%3B Ligase%3B Mitochondrion%3B Nucleotide-binding%3B Transit peptide%3B Activates acetate so that it can be used for lipid synthesis or for energy generation%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: gdj:Gdia_2626 propionyl-CoA synthetase gene gene2464 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02465 S101447_02466 S101447_02466 S101447_02466 2608485 2609246 - 3-oxoacyl-[acyl-carrier-protein] reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: smz:SMD_2369 3-oxoacyl-(acyl-carrier protein) reductase gene gene2465 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02466 S101447_02467 S101447_02467 S101447_02467 2609349 2610281 + putative HTH-type transcriptional regulator LtrA DNA-binding%3B Transcription%3B Transcription regulation%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2466 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02467 S101447_02468 S101447_02468 S101447_02468 2610257 2611198 - hypothetical protein gene gene2467 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02468 S101447_02469 S101447_02469 S101447_02469 2611298 2612185 + HTH-type transcriptional regulator AlsR Acetoin biosynthesis%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Regulates the expression of the alsSD operon for acetoin biosynthesis. Contains 1 HTH lysR-type DNA-binding domain gene gene2468 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02469 S101447_02470 S101447_02470 S101447_02470 2612339 2612707 + hypothetical protein gene gene2469 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02470 S101447_02471 S101447_02471 dehH dehH 2613444 2614337 + Haloacetate dehalogenase Aromatic hydrocarbons catabolism%3B Cell membrane%3B Cytoplasm%3B Hydrolase%3B Membrane%3B Involved in catabolic degradation of epoxides. Shows highest activity towards C6 and C7 carbocyclic epoxides. Also active towards linear 1%2C2-epoxyalkanes. Belongs to the AB hydrolase superfamily. Epoxide hydrolase family%3B KEGG: apk:APA386B_1P230 haloacetate dehalogenase gene gene2470 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02471 S101447_02472 S101447_02472 S101447_02472 2614501 2615067 - hypothetical protein gene gene2471 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02472 S101447_02473 S101447_02473 S101447_02473 2615216 2615863 + Glutathione transferase Transferase%3B Belongs to the GST superfamily%3B Contains 1 GST C-terminal domain%3B Contains 1 GST N-terminal domain%3B KEGG: paes:SCV20265_3756 glutathione S-transferase gene gene2472 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02473 S101447_02474 S101447_02474 S101447_02474 2616118 2617257 + Microsomal epoxide hydrolase Aromatic hydrocarbons catabolism%3B Endoplasmic reticulum%3B Hydrolase%3B Membrane%3B Microsome%3B Signal-anchor%3B Transmembrane%3B Transmembrane helix%3B Catalyzes juvenile hormone hydrolysis%3B Belongs to the peptidase S33 family%3B KEGG: pub:SAR11_0803 microsomal epoxide hydrolase gene gene2473 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02474 S101447_02475 S101447_02475 S101447_02475 2617306 2618229 - Glycine cleavage system transcriptional activator Activator%3B Cytoplasm%3B DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2474 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02475 S101447_02476 S101447_02476 S101447_02476 2618327 2619526 + hypothetical protein gene gene2475 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02476 S101447_02477 S101447_02477 S101447_02477 2619564 2620016 + Centromere protein Alternative splicing%3B Cell cycle%3B Cell division%3B Centromere%3B Chromosome%3B Cytoplasm%3B Cytoskeleton%3B Kinetochore%3B Mitosis%3B Nucleus%3B Phosphoprotein%3B Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization%2C chromosome alignment and cytokinesis%3B Belongs to the Gfa family gene gene2476 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02477 S101447_02478 S101447_02478 S101447_02478 2620439 2620735 - hypothetical protein gene gene2477 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02478 S101447_02479 S101447_02479 S101447_02479 2620771 2621304 - hypothetical protein gene gene2478 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02479 S101447_02480 S101447_02480 katE katE 2621301 2622389 - Catalase Heme%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Peroxidase%3B Has an organic peroxide-dependent peroxidase activity. Exhibits strong peroxidase activity using organic hydroperoxides as cosubstrates%2C weak peroxidase activity using hydrogen peroxide and negligible catalase activity. May have a role in elimination of reactive oxygen species%2C in particular by deactivating hydroperoxides%3B Belongs to the catalase family%3B KEGG: goh:B932_3307 catalase gene gene2479 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02480 S101447_02481 S101447_02481 S101447_02481 2622565 2623071 + ECF RNA polymerase sigma factor EcfG DNA-binding%3B Sigma factor%3B Stress response%3B Transcription%3B Transcription regulation%3B Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity). Regulates expression of hpnP under a variety of stresses%2C including high temperature%2C pH stress%2C and presence of nonionic osmolytes (PubMed:23524612)%3B Belongs to the sigma-70 factor family. ECF subfamily gene gene2480 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02481 S101447_02482 S101447_02482 S101447_02482 2623068 2623823 + hypothetical protein gene gene2481 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02482 S101447_02483 S101447_02483 S101447_02483 2624049 2624630 - hypothetical protein gene gene2482 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02483 S101447_02484 S101447_02484 S101447_02484 2624753 2625733 + putative oxidoreductase Oxidoreductase%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family gene gene2483 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02484 S101447_02485 S101447_02485 S101447_02485 2625838 2626953 + Transmembrane protein with metallophosphoesterase domain Hydrolase%3B Membrane%3B Metal-binding%3B Transmembrane%3B Transmembrane helix%3B Belongs to the metallophosphoesterase superfamily. LOC643853 family gene gene2484 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02485 S101447_02486 S101447_02486 nemA nemA 2627231 2628304 + Artemisinic aldehyde Delta(11(13)) reductase Cytoplasm%3B Flavoprotein%3B FMN%3B NADP%3B Oxidoreductase%3B Involved in the biosynthesis of the antimalarial endoperoxide artemisinin by catalyzing the double bond reduction of (11R)-dihydroartemisinic aldehyde to produce artemisinic aldehyde. Also able to reduce artemisinic alcohol and artemisinic acid to a lesser extent%3B Belongs to the NADH:flavin oxidoreductase/NADH oxidase family%3B KEGG: pao:Pat9b_4657 N-ethylmaleimide reductase%3B Oxidoreductases gene gene2485 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02486 S101447_02487 S101447_02487 S101447_02487 2628502 2630169 + Phosphoglucomutase (alpha-D-glucose-1%2C6-bisphosphate-dependent) Carbohydrate metabolism%3B Glucose metabolism%3B Isomerase%3B Magnesium%3B Metal-binding%3B Phosphoprotein%3B This enzyme participates in both the breakdown and synthesis of glucose. Belongs to the phosphohexose mutase family%3B KEGG: gxy:GLX_05310 phosphoglucomutase gene gene2486 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02487 S101447_02488 S101447_02488 S101447_02488 2630340 2631644 + Inner membrane symporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the sodium:galactoside symporter (TC 2. A. 2) family gene gene2487 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02488 S101447_02489 S101447_02489 S101447_02489 2631985 2632692 + Feruloyl esterase Plasmid%3B Belongs to the tannase family%3B KEGG: pao:Pat9b_4214 feruloyl esterase gene gene2488 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02489 S101447_02490 S101447_02490 S101447_02490 2632728 2633273 - hypothetical protein gene gene2489 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02490 S101447_02491 S101447_02491 S101447_02491 2633590 2634189 + hypothetical protein gene gene2490 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02491 S101447_02492 S101447_02492 S101447_02492 2634291 2634569 - hypothetical protein gene gene2491 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02492 S101447_02493 S101447_02493 S101447_02493 2634712 2636085 - Divalent metal cation transporter MntH Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B H(+)-stimulated%2C divalent metal cation uptake system%3B Belongs to the NRAMP family gene gene2492 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02493 S101447_02494 S101447_02494 S101447_02494 2636276 2636749 + Transcriptional regulator MntR Activator%3B Cytoplasm%3B DNA-binding%3B Manganese%3B Repressor%3B Transcription%3B Transcription regulation%3B In the presence of manganese%2C represses expression of mntH and mntS. Up-regulates expression of mntP (By similarity)%3B Contains 1 HTH dtxR-type DNA-binding domain gene gene2493 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02494 S101447_02495 S101447_02495 S101447_02495 2636750 2637358 - hypothetical protein gene gene2494 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02495 S101447_02496 S101447_02496 S101447_02496 2637458 2638879 + Coniferyl-aldehyde dehydrogenase NAD%3B Oxidoreductase%3B Belongs to the aldehyde dehydrogenase family%3B KEGG: shp:Sput200_3089 coniferyl-aldehyde dehydrogenase gene gene2495 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02496 S101447_02497 S101447_02497 S101447_02497 2639068 2639397 + hypothetical protein gene gene2496 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02497 S101447_02498 S101447_02498 S101447_02498 2639397 2640383 + Hemin-binding periplasmic protein HmuT Ion transport%3B Iron%3B Iron transport%3B Periplasm%3B Signal%3B Transport%3B Part of the binding-protein-dependent transport system for hemin. Contains 1 Fe/B12 periplasmic-binding domain gene gene2497 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02498 S101447_02499 S101447_02499 S101447_02499 2640380 2641432 + putative siderophore transport system permease protein YfiZ Cell membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Signal%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the ABC transporter complex YfiYZ/YfhA/YusV involved in import of the iron-hydroxamate siderophores schizokinen%2C arthrobactin and corprogen%3B Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily gene gene2498 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02499 S101447_02500 S101447_02500 S101447_02500 2641429 2642241 + Phosphonates import ATP-binding protein PhnC ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Phosphonate transport%3B Transport%3B Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3. A. 1. 9. 1) family%3B Contains 1 ABC transporter domain gene gene2499 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02500 S101447_02501 S101447_02501 isdG isdG 2642262 2642582 + Heme oxygenase (staphylobilin-producing) KEGG: pste:PSTEL_25545 heme oxygenase (staphylobilin-producing) gene gene2500 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02501 S101447_02502 S101447_02502 S101447_02502 2642664 2643251 - hypothetical protein gene gene2501 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02502 S101447_02503 S101447_02503 S101447_02503 2643411 2645732 + Lactoferrin-binding protein Cell outer membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Unknown. May be an iron-siderophore receptor. Belongs to the TonB-dependent receptor family gene gene2502 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02503 S101447_02504 S101447_02504 S101447_02504 2645955 2646554 - Nicotinamide riboside transporter Cell inner membrane%3B Cell membrane%3B Membrane%3B NAD%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Required for nicotinamide riboside transport across the inner membrane%3B Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4. B. 1) family gene gene2503 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02504 S101447_02505 S101447_02505 S101447_02505 2646591 2647472 - Thiosulfate sulfurtransferase Alternative splicing%3B Mitochondrion%3B Pyruvate%3B Repeat%3B Transferase%3B Transit peptide%3B Catalyzes the transfer of a sulfur ion from a donor to cyanide or to other thiol compounds. Substrate preference is 3- mercaptopyruvate > thiosulfate. Involved in embryo and seed development%3B Contains 2 rhodanese domains%3B KEGG: pcz:PCL1606_30080 thiosulfate/3-mercaptopyruvate sulfurtransferase gene gene2504 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02505 S101447_02506 S101447_02506 S101447_02506 2647469 2648626 - hypothetical protein gene gene2505 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02506 S101447_02507 S101447_02507 S101447_02507 2648638 2649585 - hypothetical protein gene gene2506 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02507 S101447_02508 S101447_02508 S101447_02508 2649588 2652080 - hypothetical protein gene gene2507 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02508 S101447_02509 S101447_02509 S101447_02509 2652182 2653108 + Small neutral protease regulatory protein DNA-binding%3B Transcription%3B Transcription regulation%3B Transcriptional trans-activator of the gene (mprA) for the small neutral protease. Contains 1 HTH lysR-type DNA-binding domain gene gene2508 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02509 S101447_02510 S101447_02510 S101447_02510 2653251 2653868 - hypothetical protein gene gene2509 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02510 S101447_02511 S101447_02511 S101447_02511 2653901 2655052 - hypothetical protein gene gene2510 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02511 S101447_02512 S101447_02512 S101447_02512 2655482 2656762 + Medium-chain acyl-CoA dehydrogenase KEGG: reh:H16_B1481 acyl-CoA dehydrogenase gene gene2511 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02512 S101447_02513 S101447_02513 ssuD ssuD 2656759 2658189 + Alkanesulfonate monooxygenase Flavoprotein%3B FMN%3B Monooxygenase%3B NAD%3B Oxidoreductase%3B Monooxygenase that mediates oxidation of dimethyl sulfide%2C the first step in dimethyl sulfide degradation pathway. Has much lower activity with diethyl sulfide and other short-chain alkyl methyl sulfides%3B Belongs to the NtaA/SnaA/SoxA(DszA) monooxygenase family%3B KEGG: bur:Bcep18194_B0310 alkanesulfonate monooxygenase gene gene2512 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02513 S101447_02514 S101447_02514 S101447_02514 2658192 2659355 + Alkanesulfonate monooxygenase Flavoprotein%3B FMN%3B Monooxygenase%3B Oxidoreductase%3B Catalyzes the desulfonation of aliphatic sulfonates%3B Belongs to the SsuD family%3B KEGG: gxy:GLX_02410 alkanesulfonate monooxygenase gene gene2513 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02514 S101447_02515 S101447_02515 S101447_02515 2659372 2660808 + Hydroxyacylglutathione hydrolase KEGG: gox:GOX2647 hydroxyacylglutathione hydrolase gene gene2514 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02515 S101447_02516 S101447_02516 S101447_02516 2660805 2662304 + Monosaccharide-sensing protein Membrane%3B Phosphoprotein%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family gene gene2515 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02516 S101447_02517 S101447_02517 S101447_02517 2662311 2662850 + FMN reductase (NADH) RutF Flavoprotein%3B FMN%3B NAD%3B Oxidoreductase%3B Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway%3B Belongs to the non-flavoprotein flavin reductase family. RutF subfamily%3B KEGG: gxy:GLX_02380 flavin reductase%3B With NAD(+) or NADP(+) as acceptor gene gene2516 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02517 S101447_02518 S101447_02518 S101447_02518 2662973 2665246 + hypothetical protein gene gene2517 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02518 S101447_02519 S101447_02519 S101447_02519 2665279 2666625 + Alkanesulfonate monooxygenase Flavoprotein%3B FMN%3B Monooxygenase%3B NAD%3B Oxidoreductase%3B Monooxygenase that mediates oxidation of dimethyl sulfide%2C the first step in dimethyl sulfide degradation pathway. Has much lower activity with diethyl sulfide and other short-chain alkyl methyl sulfides%3B Belongs to the NtaA/SnaA/SoxA(DszA) monooxygenase family%3B KEGG: ret:RHE_PB00125 alkanesulfonate monooxygenase gene gene2518 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02519 S101447_02520 S101447_02520 S101447_02520 2666751 2667086 + hypothetical protein gene gene2519 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02520 S101447_02521 S101447_02521 S101447_02521 2667617 2673643 - putative ATP-dependent helicase ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Belongs to the DNA2/NAM7 helicase family gene gene2520 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02521 S101447_02522 S101447_02522 S101447_02522 2673962 2674906 - Acetyl esterase Cytoplasm%3B Hydrolase%3B Serine esterase%3B Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin)%2C but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity%3B Belongs to the 'GDXG' lipolytic enzyme family%3B KEGG: hro:HELRODRAFT_168752 neutral cholesterol ester hydrolase 1%3B Carboxylic ester hydrolases gene gene2521 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02522 S101447_02523 S101447_02523 S101447_02523 2675130 2676932 - Allophanate hydrolase Arginine metabolism%3B ATP-binding%3B Biotin%3B Hydrolase%3B Ligase%3B Multifunctional enzyme%3B Nucleotide-binding%3B Involved in uracil catabolism. Hydrolysis of urea to ammonia and CO(2)%3B Belongs to the DUR1%2C2 family%3B Contains 1 ATP-grasp domain%3B Contains 1 biotin carboxylation domain%3B Contains 1 biotinyl-binding domain%3B KEGG: apt:APA01_14000 allophanate hydrolase gene gene2522 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02523 S101447_02524 S101447_02524 S101447_02524 2676971 2680510 - Urea carboxylase ATP-binding%3B Biotin%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Ligase%3B Lipid biosynthesis%3B Lipid metabolism%3B Nucleotide-binding%3B This protein is a component of the acetyl coenzyme A carboxylase comple%3B first%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA%3B Contains 1 ATP-grasp domain%3B Contains 1 biotin carboxylation domain%3B KEGG: eas:Entas_1995 urea carboxylase gene gene2523 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02524 S101447_02525 S101447_02525 S101447_02525 2680529 2681173 - uncharacterized protein gene gene2524 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02525 S101447_02526 S101447_02526 S101447_02526 2681190 2681993 - hypothetical protein gene gene2525 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02526 S101447_02527 S101447_02527 S101447_02527 2682035 2682514 - Putative nickel-responsive regulator DNA-binding%3B Metal-binding%3B Nickel%3B Transcription%3B Transcription regulation%3B Transcriptional regulator%3B Belongs to the transcriptional regulatory CopG/NikR family gene gene2526 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02527 S101447_02528 S101447_02528 S101447_02528 2682526 2683440 - Lipoprotein-releasing system ATP-binding protein LolD ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner%3B Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3. A. 1. 125) family%3B Contains 1 ABC transporter domain gene gene2527 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02528 S101447_02529 S101447_02529 S101447_02529 2683440 2684402 - Glycine betaine/L-proline transport system permease protein Amino-acid transport%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline. Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2528 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02529 S101447_02530 S101447_02530 S101447_02530 2684423 2685412 - Putative aliphatic sulfonates-binding protein Cell membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Transport%3B Part of a binding-protein-dependent transport system for aliphatic sulfonates. Putative binding protein. Belongs to the bacterial solute-binding protein SsuA/TauA family gene gene2529 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02530 S101447_02531 S101447_02531 S101447_02531 2685518 2685871 + hypothetical protein gene gene2530 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02531 S101447_02532 S101447_02532 S101447_02532 2685931 2686608 + hypothetical protein gene gene2531 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02532 S101447_02533 S101447_02533 S101447_02533 2686667 2687926 + putative oxidoreductase CzcO-like Oxidoreductase. gene gene2532 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02533 S101447_02534 S101447_02534 puuC puuC 2687926 2689407 + Mitochondrial 10-formyltetrahydrofolate dehydrogenase Acetylation%3B Mitochondrion%3B NADP%3B One-carbon metabolism%3B Oxidoreductase%3B Phosphopantetheine%3B Phosphoprotein%3B Transit peptide%3B In the N-terminal sectio%3B belongs to the GART family%3B In the C-terminal sectio%3B belongs to the aldehyde dehydrogenase family. ALDH1L subfamily%3B Contains 1 acyl carrier domain%3B KEGG: apt:APA01_42000 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase%3B With NAD(+) or NADP(+) as acceptor gene gene2533 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02534 S101447_02535 S101447_02535 S101447_02535 2689545 2689952 + 2-iminobutanoate/2-iminopropanoate deaminase KEGG: can:Cyan10605_0339 2-iminobutanoate/2-iminopropanoate deaminase gene gene2534 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02535 S101447_02536 S101447_02536 S101447_02536 2690073 2691467 + Putative purine-cytosine permease YxlA Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the purine-cytosine permease (2. A. 39) family gene gene2535 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02536 S101447_02537 S101447_02537 betA betA 2691467 2693083 + Choline dehydrogenase FAD%3B Flavoprotein%3B NAD%3B Oxidoreductase%3B Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate%3B Belongs to the GMC oxidoreductase family%3B KEGG: hak:KO116_02478 choline dehydrogenase gene gene2536 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02537 S101447_02538 S101447_02538 argE argE 2693080 2694234 + Acetylornithine deacetylase Amino-acid biosynthesis%3B Arginine biosynthesis%3B Cobalt%3B Cytoplasm%3B Hydrolase%3B Metal-binding%3B Zinc%3B Belongs to the peptidase M20A family. ArgE subfamily%3B KEGG: apt:APA01_41960 acetylornithine deacetylase gene gene2537 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02538 S101447_02539 S101447_02539 S101447_02539 2694334 2695254 + putative HTH-type transcriptional regulator YoaU DNA-binding%3B Transcription%3B Transcription regulation%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2538 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02539 S101447_02540 S101447_02540 S101447_02540 2695580 2697076 + hypothetical protein gene gene2539 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02540 S101447_02541 S101447_02541 S101447_02541 2697357 2697866 + hypothetical protein gene gene2540 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02541 S101447_02542 S101447_02542 S101447_02542 2698004 2698960 + hypothetical protein gene gene2541 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02542 S101447_02543 S101447_02543 S101447_02543 2699135 2701783 + Ferric-pseudobactin BN7/BN8 receptor Cell outer membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Specific receptor for the siderophores ferric pseudobactin BN8 and ferric pseudobactin BN7%2C iron chelating molecules that allow the organism to extract iron from the environment%2C especially under iron-restricted conditions. Belongs to the TonB-dependent receptor family gene gene2542 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02543 S101447_02544 S101447_02544 S101447_02544 2701783 2702067 + hypothetical protein gene gene2543 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02544 S101447_02545 S101447_02545 S101447_02545 2702071 2703624 + hypothetical protein gene gene2544 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02545 S101447_02546 S101447_02546 S101447_02546 2703624 2703983 + hypothetical protein gene gene2545 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02546 S101447_02547 S101447_02547 mmsA mmsA 2704059 2705552 - Malonate-semialdehyde dehydrogenase (acetylating) NADP%3B Oxidoreductase%3B Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. It appears to be important for nitrogen metabolism under N limitation conditions%3B Belongs to the aldehyde dehydrogenase family%3B KEGG: apt:APA01_13920 malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase gene gene2546 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02547 S101447_02548 S101447_02548 S101447_02548 2705578 2706660 - Shikimate transporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Symport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family gene gene2547 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02548 S101447_02549 S101447_02549 yiaY yiaY 2706986 2708173 - Alcohol dehydrogenase NAD%3B Oxidoreductase%3B Long-chain alkyl alcohol dehydrogenase that can oxidize a broad range of alkyl alcohols from ethanol to 1-triacontanol (C2 to C30) as well as 1%2C3-propanediol and acetaldehyde. The best substrate is ethanol. Also oxidizes glycerol%3B Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: aad:TC41_0786 alcohol dehydrogenase gene gene2548 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02549 S101447_02550 S101447_02550 S101447_02550 2708308 2709207 + HTH-type transcriptional regulator ClcR Activator%3B Aromatic hydrocarbons catabolism%3B Cytoplasm%3B DNA-binding%3B Plasmid%3B Transcription%3B Transcription regulation%3B Involved in regulation of chlorinated catechol metabolism. Transcriptional activator of the clcABD chlorocatechol oxidative operon. Contains 1 HTH lysR-type DNA-binding domain gene gene2549 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02550 S101447_02551 S101447_02551 S101447_02551 2709202 2711097 - N-acyl-D-amino-acid deacylase Hydrolase%3B Metal-binding%3B Zinc%3B Catalyzes the second step of the reductive pyrimidine degradation%2C the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5%2C6- dihydrouracil to N-carbamyl-alanine and of 5%2C6-dihydrothymine to N-carbamyl-amino isobutyrate%3B Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily%3B KEGG: clj:CLJU_c29960 N-acyl-D-amino-acid deacylase gene gene2550 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02551 S101447_02552 S101447_02552 hpaI hpaI 2711328 2712152 - 4-hydroxy-2-oxoheptanedioate aldolase Aromatic hydrocarbons catabolism%3B Lyase%3B Metal-binding%3B Catalyzes the reversible retro-aldol cleavage of 4- hydroxy-2-ketoheptane-1%2C7-dioate (HKHD) to pyruvate and succinic semialdehyde%3B Belongs to the HpcH/HpaI aldolase family%3B KEGG: apt:APA01_13850 4-hydroxy-2-oxoheptanedioate aldolase gene gene2551 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02552 S101447_02553 S101447_02553 S101447_02553 2712237 2714018 - Dihydroxy-acid dehydratase 4Fe-4S%3B Arabinose catabolism%3B Carbohydrate metabolism%3B Iron%3B Iron-sulfur%3B Lyase%3B Metal-binding%3B Catalyzes the dehydration of L-arabonate to L-2-keto-3- deoxyarabonate (L-KDA). Is involved in a degradation pathway of L- arabinose that allows A. brasilense to grow on L-arabinose as a sole carbon source. To a lesser extent%2C can also use D-xylonate as substrate%2C but not D-galactonate%2C D-arabonate%2C and D-gluconate%3B Belongs to the IlvD/Edd family%3B KEGG: apt:APA01_13840 dihydroxy-acid dehydratase gene gene2552 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02553 S101447_02554 S101447_02554 S101447_02554 2714152 2715060 + HTH-type transcriptional regulator AbgR DNA-binding%3B Transcription%3B Transcription regulation%3B Could be the regulator of the abg operon. Contains 1 HTH lysR-type DNA-binding domain gene gene2553 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02554 S101447_02555 S101447_02555 S101447_02555 2715215 2716582 + putative glucarate transporter Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Uptake of D-glucarate. Belongs to the major facilitator superfamily. Phthalate permease family gene gene2554 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02555 S101447_02556 S101447_02556 S101447_02556 2716678 2718525 + hypothetical protein gene gene2555 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02556 S101447_02557 S101447_02557 S101447_02557 2718602 2719888 - Putative metabolite transport protein NicT Aromatic hydrocarbons catabolism%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Probable transporter%2C possibly involved in the aerobic nicotinate degradation pathway%3B Belongs to the major facilitator superfamily gene gene2556 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02557 S101447_02558 S101447_02558 S101447_02558 2720338 2722884 + hypothetical protein gene gene2557 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02558 S101447_02559 S101447_02559 tauD tauD 2723118 2724062 + Taurine dioxygenase Dioxygenase%3B Hydroxylation%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Vitamin C%3B Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite%2C aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid%2C 3- (N-morpholino)propanesulfonic acid and 1%2C3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme. Belongs to the TfdA dioxygenase family%3B KEGG: apt:APA01_13710 taurine dioxygenase gene gene2558 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02559 S101447_02560 S101447_02560 S101447_02560 2724084 2725379 + hypothetical protein gene gene2559 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02560 S101447_02561 S101447_02561 S101447_02561 2725410 2726186 + Putative aliphatic sulfonates transport permease protein SsuC Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2560 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02561 S101447_02562 S101447_02562 ssuB ssuB 2726183 2726929 + Phosphonates import ATP-binding protein PhnC ATP-binding%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Phosphonate transport%3B Transport%3B Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3. A. 1. 9. 1) family%3B Contains 1 ABC transporter domain%3B KEGG: apt:APA01_13680 sulfonate transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene2561 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02562 S101447_02563 S101447_02563 S101447_02563 2726981 2727931 + Putative aliphatic sulfonates-binding protein Periplasm%3B Signal%3B Transport%3B Part of a binding-protein-dependent transport system for aliphatic sulfonates. Putative binding protein. Belongs to the bacterial solute-binding protein SsuA/TauA family gene gene2562 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02563 S101447_02564 S101447_02564 S101447_02564 2728110 2728616 + hypothetical protein gene gene2563 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02564 S101447_02565 S101447_02565 S101447_02565 2728630 2728758 + hypothetical protein gene gene2564 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02565 S101447_02566 S101447_02566 S101447_02566 2728751 2729728 + hypothetical protein gene gene2565 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02566 S101447_02567 S101447_02567 S101447_02567 2729854 2732313 + Ferrichrysobactin receptor Cell outer membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Involved in the initial step of iron uptake by binding chrysobactin%2C an iron chelatin siderophore that allows the bacteria to extract iron from the environment. Belongs to the TonB-dependent receptor family gene gene2566 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02567 S101447_02568 S101447_02568 S101447_02568 2732457 2733038 + hypothetical protein gene gene2567 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02568 S101447_02569 S101447_02569 S101447_02569 2733106 2734080 + hypothetical protein gene gene2568 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02569 S101447_02570 S101447_02570 S101447_02570 2734264 2736870 + Ferric-pseudobactin M114 receptor PbuA Cell outer membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Specific receptor for the siderophore ferric pseudobactin m114. Belongs to the TonB-dependent receptor family gene gene2569 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02570 S101447_02571 S101447_02571 S101447_02571 2736890 2737021 - hypothetical protein gene gene2570 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02571 S101447_02572 S101447_02572 S101447_02572 2737273 2737572 + hypothetical protein gene gene2571 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02572 S101447_02573 S101447_02573 S101447_02573 2737714 2738511 + hypothetical protein gene gene2572 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02573 S101447_02574 S101447_02574 S101447_02574 2738508 2738759 + hypothetical protein gene gene2573 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02574 S101447_02575 S101447_02575 S101447_02575 2738756 2739505 + Biopolymer transport protein ExbB Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity)%3B Belongs to the ExbB/TolQ family gene gene2574 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02575 S101447_02576 S101447_02576 S101447_02576 2739511 2739975 + Protein TolR Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-independent uptake of proteins%3B Belongs to the ExbD/TolR family gene gene2575 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02576 S101447_02577 S101447_02577 S101447_02577 2739972 2740829 + Mucin-2 Autocatalytic cleavage%3B Disulfide bond%3B Glycoprotein%3B Phosphoprotein%3B Polymorphism%3B Repeat%3B Secreted%3B Signal%3B Coats the epithelia of the intestines%2C airways%2C and other mucus membrane-containing organs. Thought to provide a protective%2C lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer%3B Contains 1 CTCK (C-terminal cystine knot-like) domain%3B Contains 1 TIL (trypsin inhibitory-like) domain%3B Contains 2 VWFC domains%3B Contains 4 VWFD domains gene gene2576 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02577 S101447_02578 S101447_02578 S101447_02578 2740874 2741389 + hypothetical protein gene gene2577 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02578 S101447_02579 S101447_02579 S101447_02579 2741410 2742615 - Putative sialic acid transporter Cell inner membrane%3B Cell membrane%3B Membrane%3B Sugar transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B May be a sugar-cation symporter involved in sialic acid uptake%3B Belongs to the major facilitator superfamily. Sugar transporter (TC 2. A. 1. 1) family. Sialic acid transporter (TC 2. A. 1. 12. 1) subfamily gene gene2578 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02579 S101447_02580 S101447_02580 S101447_02580 2742894 2743661 - HTH-type transcriptional regulator RipA DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Under iron limitation%2C RipA negatively controls the expression of the acn (aconitase)%2C catA (catechol 1%2C2 dioxygenase)%2C leuCD (isopropylmalate dehydratase)%2C narKGHJI (nitrite/nitrate transporter and nitrate reductase)%2C sdhCAB (succinate dehydrogenase)%2C pta (phosphotransacetylase) and katA (catalase) genes. Binds to the consensus sequence in the promoter region%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene2579 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02580 S101447_02581 S101447_02581 S101447_02581 2743797 2744183 + uncharacterized protein gene gene2580 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02581 S101447_02582 S101447_02582 S101447_02582 2744243 2746549 - Adhesin/invasin TibA autotransporter Cell adhesion%3B Cell outer membrane%3B Glycoprotein%3B Membrane%3B Periplasm%3B Repeat%3B Secreted%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Virulence%3B Mediates both adhesion to and invasion of human intestine epithelial cells. Also mediates bacterial cell aggregation via intercellular TibA-TibA interaction. Enhances biofilm formation%3B Contains 1 autotransporter (TC 1. B. 12) domain gene gene2581 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02582 S101447_02583 S101447_02583 S101447_02583 2746556 2747002 - hypothetical protein gene gene2582 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02583 S101447_02584 S101447_02584 S101447_02584 2747522 2749669 - hypothetical protein gene gene2583 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02584 S101447_02585 S101447_02585 S101447_02585 2749975 2751417 + Polyphosphate kinase KEGG: roa:Pd630_LPD04655 polyphosphate kinase gene gene2584 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02585 S101447_02586 S101447_02586 S101447_02586 2751590 2752171 + hypothetical protein gene gene2585 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02586 S101447_02587 S101447_02587 S101447_02587 2752168 2752497 + Quaternary ammonium compound-resistance protein QacG Cell membrane%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds. Belongs to the small multidrug resistance (SMR) protein family gene gene2586 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02587 S101447_02588 S101447_02588 S101447_02588 2752545 2753639 + Multidrug resistance protein MdtA Cell inner membrane%3B Cell membrane%3B Membrane%3B Signal%3B Transport%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene2587 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02588 S101447_02589 S101447_02589 S101447_02589 2753636 2756680 + Multidrug resistance protein MdtC Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MdtC subfamily gene gene2588 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02589 S101447_02590 S101447_02590 S101447_02590 2756677 2758128 + Nodulation protein Cell membrane%3B Lipoprotein%3B Membrane%3B Nodulation%3B Palmitate%3B Plasmid%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene2589 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02590 S101447_02591 S101447_02591 S101447_02591 2758148 2759455 - Heat shock protein hsp88 ATP-binding%3B Cytoplasm%3B Nucleotide-binding%3B Stress response%3B Belongs to the heat shock protein 70 family gene gene2590 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02591 S101447_02592 S101447_02592 S101447_02592 2759520 2760167 - hypothetical protein gene gene2591 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02592 S101447_02593 S101447_02593 S101447_02593 2760188 2760943 - hypothetical protein gene gene2592 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02593 S101447_02594 S101447_02594 S101447_02594 2760973 2762676 - ABC transporter D family member 2%2C chloroplastic Acetylation%3B ATP-binding%3B Chloroplast%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Plastid%3B Transit peptide%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3. A. 1. 203) subfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene2593 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02594 S101447_02595 S101447_02595 S101447_02595 2762663 2764909 - FhuE receptor Cell outer membrane%3B Ion transport%3B Iron%3B Iron transport%3B Membrane%3B Receptor%3B Signal%3B TonB box%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Required for the uptake of Fe(3+) via coprogen%2C ferrioxamine B%2C and rhodotorulic acid. Belongs to the TonB-dependent receptor family gene gene2594 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02595 S101447_02596 S101447_02596 S101447_02596 2765046 2765495 - hypothetical protein gene gene2595 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02596 S101447_02597 S101447_02597 S101447_02597 2765811 2766113 + hypothetical protein gene gene2596 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02597 S101447_02598 S101447_02598 thiD thiD 2766161 2766991 - Hydroxymethylpyrimidine kinase ATP-binding%3B Kinase%3B Nucleotide-binding%3B Thiamine biosynthesis%3B Transferase%3B Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP%2C and of HMP to HMP-P%3B Belongs to the ThiD family%3B KEGG: apt:APA01_13250 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase gene gene2597 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02598 S101447_02599 S101447_02599 S101447_02599 2767359 2767901 + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase Acyltransferase%3B Transferase%3B Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It can use a variety of substrates including spermidine%2C spermine and N(8)-acetylspermidine%2C 7- aminocephalosporanic acid%2C colistin and thiamine%3B Contains 1 N-acetyltransferase domain%3B KEGG: fau:Fraau_0599 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase gene gene2598 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02599 S101447_02600 S101447_02600 hutI hutI 2768008 2769348 - Imidazolonepropionase Hydrolase%3B Manganese%3B Belongs to the adenine deaminase family%3B KEGG: salb:XNR_1968 imidazolonepropionase gene gene2599 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02600 S101447_02601 S101447_02601 chvB chvB 2769414 2777972 - Protein NdvB Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Involved in the production of beta-(1%2C2)-glucan. It is involved not only in invasion but also in bacteroid development. To A. tumefaciens ChvB%3B KEGG: apk:APA386B_158 cyclic beta-1%2C2-glucan synthetase%3B Hexosyltransferases gene gene2600 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02601 S101447_02602 S101447_02602 S101447_02602 2778024 2778239 - hypothetical protein gene gene2601 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02602 S101447_02603 S101447_02603 S101447_02603 2778480 2778902 - Peptidyl-tRNA hydrolase ArfB Cytoplasm%3B Hydrolase%3B Translation regulation%3B Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters (By similarity)%3B Belongs to the prokaryotic/mitochondrial release factor family gene gene2602 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02603 S101447_02604 S101447_02604 S101447_02604 2779081 2781216 + Catalase Heme%3B Hydrogen peroxide%3B Iron%3B Metal-binding%3B Oxidoreductase%3B Peroxidase%3B Plasmid%3B Decomposes hydrogen peroxide into water and oxyge%3B serves to protect cells from the toxic effects of hydrogen peroxide. Could protect cells in nodules which have a high potential to produce hydrogen peroxide because of the strong reducing conditions required for nitrogen fixation and the action of several proteins. Belongs to the catalase family. HPII subfamily%3B KEGG: apt:APA01_13180 catalase gene gene2603 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02604 S101447_02605 S101447_02605 S101447_02605 2781462 2782694 - Na(+)/H(+) antiporter NhaA Antiport%3B Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Sodium%3B Sodium transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons%3B Belongs to the NhaA Na(+)/H(+) (TC 2. A. 33) antiporter family gene gene2604 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02605 S101447_02606 S101447_02606 S101447_02606 2782795 2783979 - Triacylglycerol lipase KEGG: mul:MUL_0787 triacylglycerol lipase gene gene2605 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02606 S101447_02607 S101447_02607 S101447_02607 2784116 2784697 + hypothetical protein gene gene2606 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02607 S101447_02608 S101447_02608 S101447_02608 2784867 2785421 + hypothetical protein gene gene2607 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02608 S101447_02609 S101447_02609 S101447_02609 2785477 2787639 + Squalene--hopene cyclase Cell membrane%3B Isomerase%3B Lyase%3B Membrane%3B Repeat%3B Catalyzes the cyclization of squalene into hopene. Belongs to the terpene cyclase/mutase family%3B Contains 7 PFTB repeats%3B KEGG: apt:APA01_13100 squalene-hopene/tetraprenyl-beta-curcumene cyclase gene gene2608 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02609 S101447_02610 S101447_02610 S101447_02610 2787714 2788409 - hypothetical protein gene gene2609 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02610 S101447_02611 S101447_02611 S101447_02611 2788438 2789535 - UPF0324 membrane protein Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Belongs to the UPF0324 family gene gene2610 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02611 S101447_02612 S101447_02612 S101447_02612 2789575 2790489 + putative RuBisCO transcriptional regulator Chloroplast%3B DNA-binding%3B Plastid%3B Transcription%3B Transcription regulation%3B Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2611 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02612 S101447_02613 S101447_02613 S101447_02613 2790513 2791958 - Outer membrane protein OprM Antibiotic resistance%3B Cell outer membrane%3B Lipoprotein%3B Membrane%3B Palmitate%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over- expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pum%3B the antibiotics exported are those exported by the intact MexCD pump%2C showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the MexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane. The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP)%2C showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter. Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene2612 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02613 S101447_02614 S101447_02614 S101447_02614 2791965 2793092 - Inner membrane transport permease Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the ABC-2 integral membrane protein family%3B Contains 1 ABC transmembrane type-2 domain gene gene2613 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02614 S101447_02615 S101447_02615 S101447_02615 2793092 2795827 - putative ABC transporter ATP-binding protein YhcG ATP-binding%3B Nucleotide-binding%3B Transport%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene2614 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02615 S101447_02616 S101447_02616 S101447_02616 2795827 2796810 - uncharacterized protein Signal. gene gene2615 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02616 S101447_02617 S101447_02617 S101447_02617 2797223 2797498 + hypothetical protein gene gene2616 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02617 S101447_02618 S101447_02618 S101447_02618 2798066 2798776 + Zinc finger homeobox protein Acetylation%3B Alternative splicing%3B Chromosomal rearrangement%3B Coiled coil%3B DNA-binding%3B Homeobox%3B Metal-binding%3B Nucleus%3B Phosphoprotein%3B Polymorphism%3B Repeat%3B Repressor%3B Transcription%3B Transcription regulation%3B Zinc%3B Zinc-finger%3B May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation%3B Belongs to the krueppel C2H2-type zinc-finger protein family%3B Contains 20 C2H2-type zinc fingers%3B Contains 4 homeobox DNA-binding domains gene gene2617 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02618 S101447_02619 S101447_02619 S101447_02619 2798867 2799844 + hypothetical protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-independent uptake of proteins%3B Belongs to the ExbB/TolQ family gene gene2618 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02619 S101447_02620 S101447_02620 S101447_02620 2799874 2800293 + Biopolymer transport protein ExbD Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates%3B Belongs to the ExbD/TolR family gene gene2619 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02620 S101447_02621 S101447_02621 S101447_02621 2800348 2800788 + Biopolymer transport protein exbD1 Cell inner membrane%3B Cell membrane%3B Membrane%3B Protein transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates%3B Belongs to the ExbD/TolR family gene gene2620 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02621 S101447_02622 S101447_02622 S101447_02622 2800908 2802470 + Gamma-glutamyltransferase Acyltransferase%3B Hydrolase%3B Protease%3B Transferase%3B Zymogen%3B Belongs to the gamma-glutamyltransferase family%3B KEGG: sno:Snov_1719 gamma-glutamyltranspeptidase / glutathione hydrolase gene gene2621 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02622 S101447_02623 S101447_02623 guaD guaD 2802467 2803789 - Guanine deaminase Hydrolase%3B Metal-binding%3B Zinc%3B Catalyzes the hydrolytic deamination of guanine%2C producing xanthine and ammonia%3B Belongs to the ATZ/TRZ family%3B KEGG: apt:APA01_12970 guanine deaminase gene gene2622 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02623 S101447_02624 S101447_02624 S101447_02624 2803794 2804696 - HTH-type transcriptional regulator BudR DNA-binding%3B Transcription%3B Transcription regulation%3B Regulator of the budABC operon for 2%2C3-butanediol synthesis%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2623 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02624 S101447_02625 S101447_02625 S101447_02625 2804853 2806271 + hypothetical protein gene gene2624 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02625 S101447_02626 S101447_02626 hpxB hpxB 2806299 2807192 + Allantoinase Carbohydrate metabolism%3B Chitin degradation%3B Hydrolase%3B Polysaccharide degradation%3B Sporulation%3B Hydrolyzes the N-acetamido groups of N-acetyl-D- glucosamine residues in chitin. Required for proper spore formation%3B Belongs to the polysaccharide deacetylase family%3B KEGG: pct:PC1_0659 allantoinase gene gene2625 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02626 S101447_02627 S101447_02627 uraD uraD 2807189 2807698 + 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase Decarboxylase%3B Lyase%3B Multifunctional enzyme%3B Oxidoreductase%3B Purine metabolism%3B Catalyzes two steps in the degradation of uric acid%2C i. e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin (By similarity)%3B In the N-terminal sectio%3B belongs to the OHCU decarboxylase family%3B In the C-terminal sectio%3B belongs to the uricase family%3B KEGG: gdj:Gdia_0215 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase gene gene2626 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02627 S101447_02628 S101447_02628 uraH uraH 2807695 2808027 + Hydroxyisourate hydrolase Hydrolase%3B Purine metabolism%3B Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)%3B Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily%3B KEGG: eae:EAE_19200 5-hydroxyisourate hydrolase gene gene2627 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02628 S101447_02629 S101447_02629 S101447_02629 2808031 2809491 + Uric acid permease PucK Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Uptake of uric acid%3B Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2. A. 40) subfamily gene gene2628 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02629 S101447_02630 S101447_02630 xdhA xdhA 2809527 2811008 + Xanthine dehydrogenase 2Fe-2S%3B Cytoplasm%3B FAD%3B Flavoprotein%3B Glycoprotein%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Molybdenum%3B NAD%3B Oxidoreductase%3B Purine metabolism%3B Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Oxidizes xanthine%2C hypoxanthine and pterine at high rates. Can also act on purine and guanine%3B Belongs to the xanthine dehydrogenase family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: apt:APA01_12900 xanthine dehydrogenase small subunit%3B overlaps another CDS with the same product name gene gene2629 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02630 S101447_02631 S101447_02631 xdhB xdhB 2811001 2813346 + Xanthine dehydrogenase 2Fe-2S%3B Cytoplasm%3B FAD%3B Flavoprotein%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Molybdenum%3B Oxidoreductase%3B Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles (By similarity)%3B Belongs to the xanthine dehydrogenase family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: apt:APA01_12890 xanthine dehydrogenase large subunit%3B overlaps another CDS with the same product name gene gene2630 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02631 S101447_02632 S101447_02632 S101447_02632 2813360 2814175 + hypothetical protein gene gene2631 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02632 S101447_02633 S101447_02633 S101447_02633 2814179 2815534 - Asparaginyl-tRNA synthase (glutamine-hydrolyzing) ATP-binding%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)%3B Belongs to the amidase family. GatA subfamily%3B KEGG: apt:APA01_12870 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A gene gene2632 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02633 S101447_02634 S101447_02634 S101447_02634 2815531 2815719 - hypothetical protein gene gene2633 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02634 S101447_02635 S101447_02635 S101447_02635 2815732 2816136 - hypothetical protein gene gene2634 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02635 S101447_02636 S101447_02636 pucG pucG 2816155 2817381 - Serine--pyruvate aminotransferase%2C mitochondrial Acetylation%3B Alternative initiation%3B Aminotransferase%3B Mitochondrion%3B Peroxisome%3B Pyridoxal phosphate%3B Transferase%3B Transit peptide%3B Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: apt:APA01_12840 (S)-ureidoglycine-glyoxylate aminotransferase%3B Transaminases gene gene2635 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02636 S101447_02637 S101447_02637 allC allC 2817399 2818673 - Allantoate deiminase Endoplasmic reticulum%3B Hydrolase%3B Manganese%3B Metal-binding%3B Purine metabolism%3B Signal%3B Involved in the catabolism of purine nucleotides. Can use allantoate as substrate%2C but not Nalpha-carbamoyl-L-Asp%2C Nalpha-carbamoyl-L-Ala or Nalpha-carbamoyl-Gly. The sequential activity of AAH%2C UGLYAH and UAH allows a complete purine breakdown without the intermediate generation of urea%3B Belongs to the peptidase M20A family%3B KEGG: apt:APA01_12830 allantoate deiminase gene gene2636 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02637 S101447_02638 S101447_02638 S101447_02638 2818929 2819042 + hypothetical protein gene gene2637 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02638 S101447_02639 S101447_02639 S101447_02639 2819054 2821393 + hypothetical protein gene gene2638 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02639 S101447_02640 S101447_02640 S101447_02640 2821459 2822829 + 8-oxoguanine deaminase Hydrolase%3B Metal-binding%3B Zinc%3B Specifically deaminates 8-Oxoguanine (8-oxoG) to uric acid. 8-oxoG is formed via the oxidation of guanine within DNA by reactive oxygen species and leads%2C if uncorrected%2C to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions%3B Belongs to the ATZ/TRZ family%3B KEGG: msr:AU15_13860 8-oxoguanine deaminase gene gene2639 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02640 S101447_02641 S101447_02641 S101447_02641 2822850 2823860 - Gibberellin 3-beta-dioxygenase Dioxygenase%3B Iron%3B Metal-binding%3B Oxidoreductase%3B 2-oxoglutarate (OG)- and Fe(II)-dependent dioxygenase (2OGD)involved in scopoletin biosynthesis. Converts feruloyl CoA into 6'-hydroxyferuloyl CoA but has no activity with ferulic acid%2C feruloylquinic acid%2C caffeic acid%2C caffeoyl CoA%2C p-coumaric acid%2C cinnamic acid%2C cinnamoyl CoA or benzoyl CoA%3B Belongs to the iron/ascorbate-dependent oxidoreductase family%3B Contains 1 Fe2OG dioxygenase domain%3B KEGG: sot:102585516 gibberellin 3-beta-dioxygenase gene gene2640 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02641 S101447_02642 S101447_02642 S101447_02642 2824093 2824860 - Carnitine transport permease protein OpuCB Cell membrane%3B Membrane%3B Stress response%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Part of the ABC transporter complex OpuCABCD involved in carnitine uptake. Probably responsible for the translocation of the substrate across the membrane. Involved%2C with BetL and GbuABC%2C in osmoprotection and cryoprotection of Listeria. Can also mediate weak glycine betaine transport%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene2641 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02642 S101447_02643 S101447_02643 S101447_02643 2824864 2825655 - Spermidine/putrescine import ATP-binding protein PotA ATP-binding%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene2642 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02643 S101447_02644 S101447_02644 S101447_02644 2825692 2826207 - hypothetical protein gene gene2643 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02644 S101447_02645 S101447_02645 S101447_02645 2826392 2827384 + hypothetical protein gene gene2644 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02645 S101447_02646 S101447_02646 atzB atzB 2827381 2828751 + Hydroxydechloroatrazine ethylaminohydrolase Hydrolase%3B Metal-binding%3B Zinc%3B Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine%2C whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine%2C S-adenosyl-L-homocysteine and adenosine to a small extent%3B Belongs to the MTA/SAH deaminase family%3B KEGG: sgp:SpiGrapes_0013 hydroxyatrazine ethylaminohydrolase gene gene2645 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02646 S101447_02647 S101447_02647 phzF phzF 2828781 2829653 - Trans-2%2C3-dihydro-3-hydroxyanthranilate isomerase Antibiotic biosynthesis%3B Isomerase%3B Isomerase that catalyzes the condensation of two molecules of trans-2%2C3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system. The final product is not yet known (By similarity)%3B Belongs to the PhzF family%3B KEGG: eca:ECA2699 trans-2%2C3-dihydro-3-hydroxyanthranilate isomerase gene gene2646 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02647 S101447_02648 S101447_02648 panE panE 2829670 2830584 - 2-dehydropantoate 2-reductase Cytoplasm%3B NADP%3B Oxidoreductase%3B Pantothenate biosynthesis%3B Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid%3B Belongs to the ketopantoate reductase family%3B KEGG: apk:APA386B_108 2-dehydropantoate 2-reductase gene gene2647 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02648 S101447_02649 S101447_02649 S101447_02649 2830803 2832107 + Inner membrane transport protein Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily gene gene2648 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02649 S101447_02650 S101447_02650 phnA phnA 2832168 2832533 - Phosphonoacetate hydrolase KEGG: apt:APA01_12710 phosphonoacetate hydrolase gene gene2649 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02650 S101447_02651 S101447_02651 frmA frmA 2832724 2832828 + S-(hydroxymethyl)glutathione dehydrogenase KEGG: dja:HY57_12100 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase gene gene2650 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02651 S101447_02652 S101447_02652 S101447_02652 2832897 2833838 + S-(hydroxymethyl)glutathione dehydrogenase Acetylation%3B Cytoplasm%3B Metal-binding%3B NAD%3B Oxidoreductase%3B Phosphoprotein%3B Zinc%3B Belongs to the zinc-containing alcohol dehydrogenase family%3B KEGG: eco:b0356 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase gene gene2651 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02652 S101447_02653 S101447_02653 treA treA 2833854 2835905 - Alpha%2Calpha-trehalase Glycosidase%3B Hydrolase%3B Periplasm%3B Signal%3B Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system%3B Belongs to the glycosyl hydrolase 37 family%3B KEGG: apt:APA01_12690 alpha%2Calpha-trehalase gene gene2652 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02653 S101447_02654 S101447_02654 S101447_02654 2835971 2837779 - Cytochrome c bioproteinis ATP-binding export protein CcmA ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Cytochrome c-type biogenesis%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochrome%3B once thought to export heme%2C this seems not to be the case%2C but its exact role is uncertain. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. CcmA exporter (TC 3. A. 1. 107) family%3B Contains 1 ABC transporter domain gene gene2653 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02654 S101447_02655 S101447_02655 S101447_02655 2837831 2838580 - Phyllosphere-induced regulator PhyR Phosphoprotein%3B Transcription%3B Transcription regulation%3B Key regulator for adaptation to epiphytic life (leaf colonizing) of the bacterium. Positively regulates several genes including katE%2C sodA%2C hsp20%2C dps and gloA. However%2C it is not known whether this regulation is direct or indirect. Also induces several dehydrogenases. Contains 1 response regulatory domain gene gene2654 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02655 S101447_02656 S101447_02656 S101447_02656 2838816 2839214 + ECF RNA polymerase sigma factor EcfG DNA-binding%3B Sigma factor%3B Stress response%3B Transcription%3B Transcription regulation%3B Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity). Regulates expression of hpnP under a variety of stresses%2C including high temperature%2C pH stress%2C and presence of nonionic osmolytes (PubMed:23524612)%3B Belongs to the sigma-70 factor family. ECF subfamily gene gene2655 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02656 S101447_02657 S101447_02657 S101447_02657 2839322 2839915 + ECF RNA polymerase sigma factor EcfG DNA-binding%3B Sigma factor%3B Stress response%3B Transcription%3B Transcription regulation%3B Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity). Regulates expression of hpnP under a variety of stresses%2C including high temperature%2C pH stress%2C and presence of nonionic osmolytes (PubMed:23524612)%3B Belongs to the sigma-70 factor family. ECF subfamily gene gene2656 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02657 S101447_02658 S101447_02658 S101447_02658 2840029 2840202 + hypothetical protein gene gene2657 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02658 S101447_02659 S101447_02659 S101447_02659 2840208 2841986 + putative sensor histidine kinase pdtaS ATP-binding%3B Kinase%3B Nucleotide-binding%3B Phosphoprotein%3B Transferase%3B Two-component regulatory system%3B Member of the two-component regulatory system pdtaR/pdtaS. Autophosphorylates%2C probably on a histidine residue%2C and transfers its phosphate group to pdtaR (By similarity)%3B Contains 1 histidine kinase domain%3B KEGG: gbe:GbCGDNIH1_0757 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene2658 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02659 S101447_02660 S101447_02660 S101447_02660 2842079 2843803 + Transport ATP-binding protein AarD ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene2659 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02660 S101447_02661 S101447_02661 S101447_02661 2843806 2845500 + putative ABC transporter ATP-binding protein ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Nucleotide-binding%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the ABC transporter superfamily. MsbA family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene2660 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02661 S101447_02662 S101447_02662 coxB coxB 2845577 2845954 + Cytochrome-c oxidase KEGG: ctt:CtCNB1_3941 cytochrome c oxidase subunit II gene gene2661 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02662 S101447_02663 S101447_02663 recQ recQ 2845959 2847839 + DNA helicase ATP-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B Nucleus%3B DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity)%3B Belongs to the helicase family. RecQ subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: apt:APA01_12590 ATP-dependent DNA helicase RecQ gene gene2662 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02663 S101447_02664 S101447_02664 S101447_02664 2847836 2848606 + Glycerol-3-phosphate regulon repressor DNA-binding%3B Glycerol metabolism%3B Repressor%3B Transcription%3B Transcription regulation%3B Repressor of the glycerol-3-phosphate regulon%3B Contains 1 HTH deoR-type DNA-binding domain gene gene2663 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02664 S101447_02665 S101447_02665 glpA glpA 2848747 2850267 + Glycerol-3-phosphate dehydrogenase Cytoplasm%3B FAD%3B Flavoprotein%3B Glycerol metabolism%3B Oxidoreductase%3B Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family%3B KEGG: apt:APA01_12570 glycerol-3-phosphate dehydrogenase gene gene2664 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02665 S101447_02666 S101447_02666 S101447_02666 2850325 2851143 + putative aquaporin PIP2-7 Alternative splicing%3B Cell membrane%3B Membrane%3B Repeat%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Aquaporins facilitate the transport of water and small neutral solutes across cell membranes%3B Belongs to the MIP/aquaporin (TC 1. A. 8) family. PIP (TC 1. A. 8. 11) subfamily gene gene2665 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02666 S101447_02667 S101447_02667 glpK glpK 2851171 2852670 + Glycerol kinase ATP-binding%3B Glycerol metabolism%3B Kinase%3B Nucleotide-binding%3B Transferase%3B Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate%3B Belongs to the FGGY kinase family%3B KEGG: apt:APA01_12552 glycerol kinase gene gene2666 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02667 S101447_02668 S101447_02668 S101447_02668 2852734 2853252 - hypothetical protein gene gene2667 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02668 S101447_02669 S101447_02669 S101447_02669 2853391 2853867 + Transcriptional repressor NrdR ATP-binding%3B DNA-binding%3B Metal-binding%3B Nucleotide-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Zinc%3B Zinc-finger%3B Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes%3B Belongs to the NrdR family%3B Contains 1 ATP-cone domain gene gene2668 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02669 S101447_02670 S101447_02670 S101447_02670 2853928 2854452 + N utilization substance protein B like protein Transcription%3B Transcription regulation%3B Transcription termination%3B Involved in the transcription termination process%3B Belongs to the NusB family gene gene2669 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02670 S101447_02671 S101447_02671 thiL thiL 2854421 2855410 + Thiamine-phosphate kinase ATP-binding%3B Kinase%3B Magnesium%3B Metal-binding%3B Nucleotide-binding%3B Thiamine biosynthesis%3B Transferase%3B Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP)%2C the active form of vitamin B1%3B Belongs to the thiamine-monophosphate kinase family%3B KEGG: apt:APA01_12510 thiamine-monophosphate kinase gene gene2670 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02671 S101447_02672 S101447_02672 S101447_02672 2855435 2856583 - Putative uncharacterized protein YghO gene gene2671 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02672 S101447_02673 S101447_02673 S101447_02673 2856729 2857457 + Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase Cell wall biogenesis/degradation%3B NAD%3B NADP%3B Oxidoreductase%3B Dpre1 and DprE2 are involved in the epimerization of decaprenylphosphoryl-beta-D-ribofuranose (DPR) to decaprenylphosphoryl-beta-D-arabinofuranose (DPA)%2C the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers. The reaction proceeds via the keto intermediate decaprenylphosphoryl-D-2-keto-erythro-pentofuranose (DPX). DprE2 catalyzes the NAD-dependent reduction at the C-2 of DPX to yield DPA%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: mtu:Rv3791 decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase gene gene2672 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02673 S101447_02674 S101447_02674 S101447_02674 2857633 2857968 + hypothetical protein gene gene2673 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02674 S101447_02675 S101447_02675 S101447_02675 2858373 2858630 - hypothetical protein gene gene2674 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02675 S101447_02676 S101447_02676 S101447_02676 2858736 2858996 - hypothetical protein gene gene2675 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02676 S101447_02677 S101447_02677 S101447_02677 2859230 2860639 - hypothetical protein gene gene2676 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02677 S101447_02678 S101447_02678 S101447_02678 2861206 2861430 - hypothetical protein gene gene2677 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02678 S101447_02679 S101447_02679 S101447_02679 2861427 2861657 - hypothetical protein gene gene2678 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02679 S101447_02680 S101447_02680 S101447_02680 2861654 2861911 - hypothetical protein gene gene2679 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02680 S101447_02681 S101447_02681 S101447_02681 2861908 2862258 - hypothetical protein gene gene2680 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02681 S101447_02682 S101447_02682 S101447_02682 2862503 2863060 - hypothetical protein gene gene2681 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02682 S101447_02683 S101447_02683 S101447_02683 2863251 2863634 - hypothetical protein gene gene2682 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02683 S101447_02684 S101447_02684 S101447_02684 2863716 2863928 + hypothetical protein gene gene2683 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02684 S101447_02685 S101447_02685 S101447_02685 2863925 2864440 + hypothetical protein gene gene2684 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02685 S101447_02686 S101447_02686 S101447_02686 2864506 2864685 - hypothetical protein gene gene2685 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02686 S101447_02687 S101447_02687 S101447_02687 2864799 2864888 + hypothetical protein gene gene2686 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02687 S101447_02688 S101447_02688 S101447_02688 2864885 2865379 + hypothetical protein gene gene2687 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02688 S101447_02689 S101447_02689 S101447_02689 2865372 2866520 + hypothetical protein gene gene2688 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02689 S101447_02690 S101447_02690 S101447_02690 2866517 2866786 + hypothetical protein gene gene2689 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02690 S101447_02691 S101447_02691 S101447_02691 2866768 2867226 + hypothetical protein gene gene2690 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02691 S101447_02692 S101447_02692 S101447_02692 2867219 2868205 - hypothetical protein gene gene2691 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02692 S101447_02693 S101447_02693 S101447_02693 2868337 2868747 + hypothetical protein gene gene2692 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02693 S101447_02694 S101447_02694 S101447_02694 2869204 2869656 + Tyrosine recombinase XerD Cell cycle%3B Cell division%3B Chromosome partition%3B Cytoplasm%3B DNA integration%3B DNA recombination%3B DNA-binding%3B Site-specific tyrosine recombinase%2C which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids%3B Belongs to the 'phage' integrase family. XerD subfamily gene gene2693 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02694 S101447_02695 S101447_02695 S101447_02695 2869700 2870326 + hypothetical protein gene gene2694 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02695 S101447_02696 S101447_02696 S101447_02696 2870323 2870652 + hypothetical protein gene gene2695 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02696 S101447_02697 S101447_02697 S101447_02697 2870666 2871055 - putative 14.9 kDa protein in rep-hol intergenic region To E. coli ydcQ gene gene2696 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02697 S101447_02698 S101447_02698 S101447_02698 2871458 2872060 + hypothetical protein gene gene2697 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02698 S101447_02699 S101447_02699 aldH aldH 2872044 2873735 + Aldehyde dehydrogenase (NADP(+)) KEGG: abd:ABTW07_2160 NADP-dependent aldehyde dehydrogenase gene gene2698 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02699 S101447_02700 S101447_02700 S101447_02700 2873723 2875033 + uncharacterized protein Belongs to the phage portal family. HK97 subfamily gene gene2699 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02700 S101447_02701 S101447_02701 S101447_02701 2875040 2875783 + Endopeptidase Clp Hydrolase%3B Mitochondrion%3B Protease%3B Serine protease%3B Transit peptide%3B Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (By similarity)%3B Belongs to the peptidase S14 family%3B KEGG: lsj:LSJ_1362 ATP-dependent Clp protease%2C protease subunit gene gene2700 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02701 S101447_02702 S101447_02702 S101447_02702 2875833 2877077 + hypothetical protein gene gene2701 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02702 S101447_02703 S101447_02703 S101447_02703 2877080 2877724 + hypothetical protein gene gene2702 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02703 S101447_02704 S101447_02704 S101447_02704 2877724 2879385 + hypothetical protein gene gene2703 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02704 S101447_02705 S101447_02705 S101447_02705 2879385 2880194 + hypothetical protein gene gene2704 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02705 S101447_02706 S101447_02706 S101447_02706 2880229 2880441 + hypothetical protein gene gene2705 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02706 S101447_02707 S101447_02707 S101447_02707 2880618 2881076 + Lysozyme Antimicrobial%3B Bacteriolytic enzyme%3B Glycosidase%3B Hydrolase%3B Essential for lysis of bacterial cell wall%2C by showing cell wall hydrolyzing activity%3B Belongs to the glycosyl hydrolase 24 family%3B KEGG: apt:APA01_19980 lysozyme gene gene2706 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02707 S101447_02708 S101447_02708 S101447_02708 2881113 2881277 + hypothetical protein gene gene2707 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02708 S101447_02709 S101447_02709 S101447_02709 2881343 2882035 + hypothetical protein gene gene2708 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02709 S101447_02710 S101447_02710 S101447_02710 2882001 2882321 + hypothetical protein gene gene2709 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02710 S101447_02711 S101447_02711 S101447_02711 2882568 2883770 - hypothetical protein gene gene2710 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02711 S101447_02712 S101447_02712 S101447_02712 2884017 2885447 - hypothetical protein gene gene2711 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02712 S101447_02713 S101447_02713 S101447_02713 2885419 2886498 - hypothetical protein gene gene2712 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02713 S101447_02714 S101447_02714 S101447_02714 2886571 2887785 - Valine--pyruvate transaminase DNA integration%3B DNA recombination%3B Viral genome integration%3B Virus entry into host cell%3B Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase%2C integrase is also necessary for excision of the prophage from the host genome. Belongs to the 'phage' integrase family%3B KEGG: lhk:LHK_02491 alanine-synthesizing transaminase gene gene2713 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02714 S101447_02715 S101447_02715 S101447_02715 2887931 2888004 - tRNA-Cys tRNA gene2714 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02715 S101447_02716 S101447_02716 S101447_02716 2888197 2888874 + Protein-L-isoaspartate(D-aspartate) O-methyltransferase Cytoplasm%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins%3B Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family%3B KEGG: apt:APA01_12440 protein-L-isoaspartate(D-aspartate) O-methyltransferase gene gene2715 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02716 S101447_02717 S101447_02717 S101447_02717 2888995 2890434 + Outer membrane efflux protein BepC Antibiotic resistance%3B Cell outer membrane%3B Coiled coil%3B Membrane%3B Signal%3B Transmembrane%3B Transmembrane beta strand%3B Transport%3B Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host%3B Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene2716 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02717 S101447_02718 S101447_02718 S101447_02718 2890471 2891112 + hypothetical protein gene gene2717 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02718 S101447_02719 S101447_02719 varS varS 2891215 2893947 + Valine--tRNA ligase Aminoacyl-tRNA synthetase%3B ATP-binding%3B Coiled coil%3B Cytoplasm%3B Ligase%3B Nucleotide-binding%3B Protein biosynthesis%3B Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine%2C to avoid such errors%2C it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner%3B Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily%3B KEGG: apk:APA386B_76 valyl-tRNA synthetase gene gene2718 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02719 S101447_02720 S101447_02720 msrA msrA 2894029 2894565 + Peptide-methionine (S)-S-oxide reductase Oxidoreductase%3B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine%3B Belongs to the MsrA Met sulfoxide reductase family%3B KEGG: pseo:OM33_00865 peptide-methionine (S)-S-oxide reductase gene gene2719 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02720 S101447_02721 S101447_02721 S101447_02721 2894578 2895933 - Lipoprotein-releasing system ATP-binding protein LolD ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner%3B Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3. A. 1. 125) family%3B Contains 1 ABC transporter domain gene gene2720 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02721 S101447_02722 S101447_02722 S101447_02722 2895949 2897697 - hypothetical protein gene gene2721 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02722 S101447_02723 S101447_02723 S101447_02723 2897694 2898173 - dUTP diphosphatase Hydrolase%3B Magnesium%3B Metal-binding%3B Nucleotide metabolism%3B This enzyme is involved in nucleotide metabolism: it produces dUMP%2C the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA%3B Belongs to the dUTPase family%3B KEGG: apt:APA01_12370 dUTP pyrophosphatase gene gene2722 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02723 S101447_02724 S101447_02724 S101447_02724 2898209 2899438 - Phosphopantothenoylcysteine decarboxylase Decarboxylase%3B Flavoprotein%3B FMN%3B Ligase%3B Lyase%3B Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine%2C in the latter compound is decarboxylated to form 4'-phosphopantotheine (By similarity)%3B In the N-terminal sectio%3B belongs to the HFCD (homo- oligomeric flavin containing Cys decarboxylase) superfamily%3B In the C-terminal sectio%3B belongs to the PPC synthetase family%3B KEGG: apt:APA01_12360 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase gene gene2723 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02724 S101447_02725 S101447_02725 ubiE ubiE 2899450 2900232 - Demethylmenaquinone methyltransferase Menaquinone biosynthesis%3B Methyltransferase%3B S-adenosyl-L-methionine%3B Transferase%3B Ubiquinone biosynthesis%3B Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1%2C4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1%2C4-benzoquinol (DMQH2)%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family%3B KEGG: apt:APA01_12350 demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1%2C4-benzoquinol methylase gene gene2724 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02725 S101447_02726 S101447_02726 mutM mutM 2900262 2901101 + DNA-formamidopyrimidine glycosylase DNA damage%3B DNA repair%3B DNA-binding%3B Glycosidase%3B Hydrolase%3B Lyase%3B Metal-binding%3B Multifunctional enzyme%3B Zinc%3B Zinc-finger%3B Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines%2C such as 7%2C8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates%3B Belongs to the FPG family%3B Contains 1 FPG-type zinc finger%3B KEGG: hap:HAPS_0857 formamidopyrimidine-DNA glycosylase gene gene2725 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02726 S101447_02727 S101447_02727 S101447_02727 2901239 2901508 + 30S ribosomal protein S20 Ribonucleoprotein%3B Ribosomal protein%3B RNA-binding%3B rRNA-binding%3B Binds directly to 16S ribosomal RNA%3B Belongs to the ribosomal protein S20P family gene gene2726 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02727 S101447_02728 S101447_02728 S101447_02728 279 710 - hypothetical protein gene gene2727 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02728 S101447_02729 S101447_02729 S101447_02729 799 1269 - Single-stranded DNA-binding protein DNA damage%3B DNA recombination%3B DNA repair%3B DNA replication%3B DNA-binding%3B Plays an important role in DNA replication%2C recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism%3B Contains 1 SSB domain gene gene2728 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02729 S101447_02730 S101447_02730 S101447_02730 2524 2946 - hypothetical protein gene gene2729 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02730 S101447_02731 S101447_02731 S101447_02731 2946 3203 - hypothetical protein gene gene2730 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02731 S101447_02732 S101447_02732 S101447_02732 3758 4108 + hypothetical protein gene gene2731 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02732 S101447_02733 S101447_02733 S101447_02733 4151 4273 - hypothetical protein gene gene2732 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02733 S101447_02734 S101447_02734 S101447_02734 4270 4488 - hypothetical protein gene gene2733 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02734 S101447_02735 S101447_02735 S101447_02735 4619 5035 - hypothetical protein gene gene2734 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02735 S101447_02736 S101447_02736 S101447_02736 5025 5270 - hypothetical protein gene gene2735 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02736 S101447_02737 S101447_02737 S101447_02737 5771 6184 + hypothetical protein gene gene2736 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02737 S101447_02738 S101447_02738 S101447_02738 6130 6939 + Putative MucR family transcriptional regulatory protein DNA-binding%3B Plasmid%3B Transcription%3B Transcription regulation%3B Belongs to the ros/MucR family gene gene2737 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02738 S101447_02739 S101447_02739 S101447_02739 7033 7224 + hypothetical protein gene gene2738 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02739 S101447_02740 S101447_02740 S101447_02740 7249 7446 + hypothetical protein gene gene2739 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02740 S101447_02741 S101447_02741 S101447_02741 7903 9288 - hypothetical protein gene gene2740 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02741 S101447_02742 S101447_02742 S101447_02742 9346 9822 - hypothetical protein gene gene2741 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02742 S101447_02743 S101447_02743 S101447_02743 10096 10386 - hypothetical protein gene gene2742 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02743 S101447_02744 S101447_02744 S101447_02744 10420 10821 - hypothetical protein gene gene2743 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02744 S101447_02745 S101447_02745 S101447_02745 10766 10933 - hypothetical protein gene gene2744 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02745 S101447_02746 S101447_02746 S101447_02746 10972 11349 - hypothetical protein gene gene2745 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02746 S101447_02747 S101447_02747 S101447_02747 11522 11794 + hypothetical protein gene gene2746 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02747 S101447_02748 S101447_02748 S101447_02748 11794 12396 + hypothetical protein gene gene2747 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02748 S101447_02749 S101447_02749 S101447_02749 12351 12986 - hypothetical protein gene gene2748 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02749 S101447_02750 S101447_02750 S101447_02750 13048 13413 - hypothetical protein gene gene2749 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02750 S101447_02751 S101447_02751 S101447_02751 13431 14042 - hypothetical protein gene gene2750 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02751 S101447_02752 S101447_02752 S101447_02752 14186 14698 + hypothetical protein gene gene2751 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02752 S101447_02753 S101447_02753 S101447_02753 14710 15369 + hypothetical protein gene gene2752 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02753 S101447_02754 S101447_02754 S101447_02754 15407 16666 - Protein SamB DNA damage%3B DNA repair%3B Plasmid%3B SOS mutagenesis%3B SOS response%3B Involved in UV protection and mutation. Belongs to the DNA polymerase type-Y family%3B Contains 1 umuC domain gene gene2753 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02754 S101447_02755 S101447_02755 umuD umuD 16663 17043 - plasmid replication initiator RepA Autocatalytic cleavage%3B DNA damage%3B DNA repair%3B Hydrolase%3B Protease%3B Serine protease%3B SOS mutagenesis%3B SOS response%3B Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template (By similarity)%3B Belongs to the peptidase S24 family%3B KEGG: paca:ID47_03355 DNA polymerase V%3B Serine endopeptidases gene gene2754 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02755 S101447_02756 S101447_02756 S101447_02756 17184 18305 - Adenosine monophosphate-protein transferase VbhT ATP-binding%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase%3B Virulence%3B Toxic component of a toxin-antitoxin (TA) module VbhT- VbhA. Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific residue of host GTPases. The resulting AMPylation affects GTPases%2C impairing actin assembly in infected cells. Contains 1 fido domain gene gene2755 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02756 S101447_02757 S101447_02757 S101447_02757 18316 18525 - hypothetical protein gene gene2756 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02757 S101447_02758 S101447_02758 S101447_02758 18625 19512 - hypothetical protein gene gene2757 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02758 S101447_02759 S101447_02759 S101447_02759 19720 21777 - DNA helicase ATP-binding%3B DNA damage%3B DNA repair%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B DNA helicase used for plasmid rolling-circle replication and also involved in UV repair. Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B Contains 1 uvrD-like helicase C-terminal domain%3B KEGG: goh:B932_3634 DNA helicase II / ATP-dependent DNA helicase PcrA gene gene2758 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02759 S101447_02760 S101447_02760 S101447_02760 21774 22463 - hypothetical protein gene gene2759 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02760 S101447_02761 S101447_02761 S101447_02761 22468 23646 - hypothetical protein gene gene2760 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02761 S101447_02762 S101447_02762 S101447_02762 23856 24071 - hypothetical protein gene gene2761 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02762 S101447_02763 S101447_02763 S101447_02763 24100 24522 - Single-stranded DNA-binding protein DNA damage%3B DNA recombination%3B DNA repair%3B DNA replication%3B DNA-binding%3B Plays an important role in DNA replication%2C recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism%3B Contains 1 SSB domain gene gene2762 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02763 S101447_02764 S101447_02764 S101447_02764 24683 25093 - hypothetical protein gene gene2763 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02764 S101447_02765 S101447_02765 S101447_02765 25137 25520 - hypothetical protein gene gene2764 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02765 S101447_02766 S101447_02766 S101447_02766 25521 26426 - DNA primase TraC Alternative initiation%3B DNA replication%3B DNA-directed RNA polymerase%3B Nucleotidyltransferase%3B Plasmid%3B Transcription%3B Transferase%3B Required for autonomous replication in E. coli. Transferred into the recipient cell during bacterial conjugation. Catalyzes the synthesis of short oligoribonucleotide primers with CpA or pCpA at their 5'-termini on a single-stranded template DNA. Contains 1 Toprim domain gene gene2765 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02766 S101447_02767 S101447_02767 S101447_02767 26450 26611 - hypothetical protein gene gene2766 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02767 S101447_02768 S101447_02768 S101447_02768 26982 27353 - hypothetical protein gene gene2767 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02768 S101447_02769 S101447_02769 S101447_02769 27582 27983 - hypothetical protein gene gene2768 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02769 S101447_02770 S101447_02770 S101447_02770 28221 28712 - hypothetical protein gene gene2769 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02770 S101447_02771 S101447_02771 S101447_02771 28787 30691 - Nucleoid occlusion protein Cell cycle%3B Cell division%3B Cytoplasm%3B DNA-binding%3B Septation%3B Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid%2C especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid%2C which would cause chromosome breakage%3B Belongs to the ParB family gene gene2770 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02771 S101447_02772 S101447_02772 S101447_02772 30879 36005 - hypothetical protein gene gene2771 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02772 S101447_02773 S101447_02773 S101447_02773 36483 37349 - putative chromosome-partitioning protein ParB Chromosome partition%3B DNA-binding%3B Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity)%3B Belongs to the ParB family gene gene2772 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02773 S101447_02774 S101447_02774 S101447_02774 37342 38397 - Protein Soj like protein ATP-binding%3B Hydrolase%3B Nucleotide-binding%3B Belongs to the ParA family gene gene2773 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02774 S101447_02775 S101447_02775 S101447_02775 38607 39530 - hypothetical protein gene gene2774 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02775 S101447_02776 S101447_02776 S101447_02776 39938 41443 - Integrase/recombinase xerD like protein DNA integration%3B DNA recombination%3B Viral genome integration%3B Virus entry into host cell%3B Belongs to the 'phage' integrase family gene gene2775 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02776 S101447_02777 S101447_02777 S101447_02777 41697 42518 - hypothetical protein gene gene2776 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02777 S101447_02778 S101447_02778 S101447_02778 42881 43681 - HTH-type transcriptional regulator RipA DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Under iron limitation%2C represses the acn (aconitase)%2C catA (catechol 1%2C2 dioxygenase)%2C leuCD (isopropylmalate dehydratase)%2C narKGHJI (nitrite/nitrate transporter and nitrate reductase)%2C sdhCAB (succinate dehydrogenase)%2C pta (phosphotransacetylase) and katA (catalase) genes%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene2777 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02778 S101447_02779 S101447_02779 S101447_02779 43754 44914 + 2-nitroimidazole transporter Antibiotic resistance%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in efflux of 2-nitroimidazole%3B Belongs to the major facilitator superfamily. Cyanate porter (TC 2. A. 1. 17) family gene gene2778 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02779 S101447_02780 S101447_02780 S101447_02780 45291 45818 - Glutathione transferase KEGG: bra:BRADO4806 glutathione S-transferase gene gene2779 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02780 S101447_02781 S101447_02781 S101447_02781 46086 46781 + hypothetical protein gene gene2780 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02781 S101447_02782 S101447_02782 S101447_02782 47343 48725 - hypothetical protein gene gene2781 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02782 S101447_02783 S101447_02783 S101447_02783 48831 48920 - hypothetical protein gene gene2782 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02783 S101447_02784 S101447_02784 S101447_02784 48917 49267 - hypothetical protein gene gene2783 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02784 S101447_02785 S101447_02785 S101447_02785 49634 50203 + hypothetical protein gene gene2784 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02785 S101447_02786 S101447_02786 S101447_02786 50255 51082 + 3-oxoacyl-(acyl-carrier-protein) reductase FabG Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B NADP%3B Oxidoreductase%3B Catalyzes the NADPH-dependent reduction of beta- ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products%2C the first reductive step in the elongation cycle of fatty acid biosynthesis%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: reh:H16_B1910 null%3B Oxidoreductases gene gene2785 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02786 S101447_02787 S101447_02787 S101447_02787 51104 51892 + hypothetical protein gene gene2786 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02787 S101447_02788 S101447_02788 S101447_02788 52615 53121 + hypothetical protein gene gene2787 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02788 S101447_02789 S101447_02789 S101447_02789 53609 54805 + putative MFS-type transporter YwfA Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Belongs to the major facilitator superfamily gene gene2788 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02789 S101447_02790 S101447_02790 S101447_02790 54838 55803 - HTH-type transcriptional activator RhaR Activator%3B Cytoplasm%3B DNA-binding%3B Repeat%3B Rhamnose metabolism%3B Transcription%3B Transcription regulation%3B Activates expression of the rhaSR operon in response to L-rhamnose%3B Contains 2 HTH araC/xylS-type DNA-binding domains gene gene2789 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02790 S101447_02791 S101447_02791 S101447_02791 55822 57333 - Succinyl-CoA:acetate CoA-transferase Transferase%3B Catalyzes the transfer of coenzyme A from propionyl-CoA to succinate. Could be part of a pathway that converts succinate to propionate%3B Belongs to the acetyl-CoA hydrolase/transferase family%3B KEGG: csq:CSCA_5289 succinyl-CoA:acetate CoA-transferase gene gene2790 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02791 S101447_02792 S101447_02792 S101447_02792 57835 58386 + hypothetical protein gene gene2791 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02792 S101447_02793 S101447_02793 S101447_02793 58937 59326 + hypothetical protein gene gene2792 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02793 S101447_02794 S101447_02794 S101447_02794 59397 61727 + hypothetical protein gene gene2793 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02794 S101447_02795 S101447_02795 cysJ cysJ 61739 63091 + Assimilatory sulfite reductase (NADPH) KEGG: bce:BC4751 sulfite reductase (NADPH) flavoprotein alpha-component gene gene2794 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02795 S101447_02796 S101447_02796 S101447_02796 63094 63801 - Protein SenC Copper%3B Metal-binding%3B Photosynthesis%3B Involved in both aerobic respiration and photosynthesis gene expression. Belongs to the SCO1/2 family%3B Contains 1 thioredoxin domain gene gene2795 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02796 S101447_02797 S101447_02797 S101447_02797 63848 64498 - hypothetical protein gene gene2796 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02797 S101447_02798 S101447_02798 S101447_02798 65315 66010 + hypothetical protein gene gene2797 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02798 S101447_02799 S101447_02799 S101447_02799 66497 68110 + Site-specific DNA-methyltransferase (adenine-specific) Methyltransferase%3B Plasmid%3B Restriction system%3B S-adenosyl-L-methionine%3B Transferase%3B Methylation of specific adenine residue%3B required for both restriction and modification activities%3B Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: apt:APA01_41890 type I restriction enzyme M protein gene gene2798 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02799 S101447_02800 S101447_02800 S101447_02800 68110 68511 + uncharacterized protein gene gene2799 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02800 S101447_02801 S101447_02801 S101447_02801 68508 68825 + Type I site-specific deoxyribonuclease KEGG: lfc:LFE_0353 type I restriction enzyme%2C S subunit%3B overlaps another CDS with the same product name gene gene2800 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02801 S101447_02802 S101447_02802 S101447_02802 68825 70078 + Type I site-specific deoxyribonuclease DNA-binding%3B Repeat%3B Restriction system%3B The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. Subunit S dictates DNA sequences specificity (By similarity)%3B Belongs to the type-I restriction system S methylase family%3B KEGG: awo:Awo_c08810 type I restriction enzyme%2C S subunit%3B overlaps another CDS with the same product name gene gene2801 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02802 S101447_02803 S101447_02803 S101447_02803 70075 73260 + Type I site-specific deoxyribonuclease ATP-binding%3B DNA-binding%3B Hydrolase%3B Nucleotide-binding%3B Restriction system%3B Subunit R is required for both nuclease and ATPase activities%2C but not for modification%3B Belongs to the HsdR family%3B Contains 1 helicase ATP-binding domain%3B KEGG: zmm:Zmob_1744 type I restriction enzyme%2C R subunit%3B overlaps another CDS with the same product name gene gene2802 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02803 S101447_02804 S101447_02804 S101447_02804 73505 75772 + hypothetical protein gene gene2803 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02804 S101447_02805 S101447_02805 S101447_02805 76326 76826 - Putative MucR family transcriptional regulatory protein DNA-binding%3B Plasmid%3B Transcription%3B Transcription regulation%3B Belongs to the ros/MucR family gene gene2804 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02805 S101447_02806 S101447_02806 S101447_02806 77057 77809 - Nuclease EXOG%2C mitochondrial Endonuclease%3B Hydrolase%3B Membrane%3B Metal-binding%3B Mitochondrion%3B Mitochondrion inner membrane%3B Nuclease%3B Transit peptide%3B Endo/exonuclease with nicking activity towards supercoiled DNA%2C a preference for single-stranded DNA and 5'-3' exonuclease activity%3B Belongs to the DNA/RNA non-specific endonuclease family gene gene2805 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02806 S101447_02807 S101447_02807 S101447_02807 78260 78532 + hypothetical protein gene gene2806 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02807 S101447_02808 S101447_02808 yhaV yhaV 78966 79457 - Toxin Endonuclease%3B Hydrolase%3B Nuclease%3B Repressor%3B Toxin%3B Transcription%3B Transcription regulation%3B Toxic component of a toxin-antitoxin (TA) module. Has RNase activity in vitro. Acts as a transcription factor. The YhaV/PrlF complex binds the prlF-yhaV operon%2C probably negatively regulating its expression (By similarity)%3B KEGG: rhi:NGR_b22220 toxin YhaV%3B Acting on ester bonds gene gene2807 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02808 S101447_02809 S101447_02809 S101447_02809 79460 79792 - hypothetical protein gene gene2808 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02809 S101447_02810 S101447_02810 S101447_02810 80477 82450 + Putative O-acetyltransferase Acyltransferase%3B Cell membrane%3B Membrane%3B Transferase%3B Transmembrane%3B Transmembrane helix%3B Belongs to the acyltransferase 3 family%3B KEGG: bra:BRADO5159 null%3B Transferring groups other than amino-acyl groups gene gene2809 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02810 S101447_02811 S101447_02811 S101447_02811 82587 83129 - hypothetical protein gene gene2810 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02811 S101447_02812 S101447_02812 S101447_02812 83299 85095 + hypothetical protein gene gene2811 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02812 S101447_02813 S101447_02813 S101447_02813 85157 86185 + hypothetical protein gene gene2812 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02813 S101447_02814 S101447_02814 S101447_02814 86175 88163 + hypothetical protein gene gene2813 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02814 S101447_02815 S101447_02815 S101447_02815 88259 89191 - hypothetical protein gene gene2814 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02815 S101447_02816 S101447_02816 S101447_02816 89570 90004 - Putative MucR family transcriptional regulatory protein DNA-binding%3B Plasmid%3B Transcription%3B Transcription regulation%3B Belongs to the ros/MucR family gene gene2815 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02816 S101447_02817 S101447_02817 S101447_02817 90350 90592 + Antitoxin RelB DNA-binding%3B Repressor%3B Stress response%3B Transcription%3B Transcription regulation%3B Antitoxin component of a type II toxin-antitoxin (TA) module. Counteracts the effect of cognate toxin RelE via direct protein-protein interaction%2C preventing RelE from entering the ribosome A site and thus inhibiting its endoribonuclease activity. An autorepressor of relBE operon transcription. 2 RelB dimers bind to 2 operator sequence%3B DNA-binding and repression is stronger when complexed with toxin/corepressor RelE by conditional cooperativity (PubMed:18501926%2C PubMed:22981948). Increased transcription rate of relBE and activation of relE is consistent with a lower level of RelB in starved cells due to degradation of RelB by protease Lon%3B Seems to be a principal mediator of cell death in liquid media%3B Belongs to the RelB/DinJ antitoxin family gene gene2816 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02817 S101447_02818 S101447_02818 S101447_02818 90855 91940 + hypothetical protein gene gene2817 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02818 S101447_02819 S101447_02819 S101447_02819 92090 92647 - hypothetical protein gene gene2818 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02819 S101447_02820 S101447_02820 S101447_02820 92650 95913 - hypothetical protein gene gene2819 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02820 S101447_02821 S101447_02821 S101447_02821 96178 97221 - putative adenosine monophosphate-protein transferase fic ATP-binding%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase%3B Probable adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (By similarity). Involved in cell filamentation induced by cyclic AMP. May have some role in cell division%3B Belongs to the fic family%3B Contains 1 fido domain gene gene2820 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02821 S101447_02822 S101447_02822 S101447_02822 97221 97577 - hypothetical protein gene gene2821 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02822 S101447_02823 S101447_02823 S101447_02823 97669 98931 - hypothetical protein gene gene2822 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02823 S101447_02824 S101447_02824 S101447_02824 99754 100032 - UPF0335 protein Plasmid%3B Belongs to the UPF0335 family gene gene2823 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02824 S101447_02825 S101447_02825 S101447_02825 100731 101738 + hypothetical protein gene gene2824 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02825 S101447_02826 S101447_02826 S101447_02826 101735 102355 + hypothetical protein gene gene2825 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02826 S101447_02827 S101447_02827 S101447_02827 102395 102703 - hypothetical protein gene gene2826 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02827 S101447_02828 S101447_02828 S101447_02828 102761 103174 - hypothetical protein gene gene2827 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02828 S101447_02829 S101447_02829 S101447_02829 103188 105563 - hypothetical protein gene gene2828 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02829 S101447_02830 S101447_02830 S101447_02830 105577 106953 - hypothetical protein gene gene2829 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02830 S101447_02831 S101447_02831 S101447_02831 106968 108155 - hypothetical protein gene gene2830 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02831 S101447_02832 S101447_02832 S101447_02832 108155 108718 - hypothetical protein gene gene2831 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02832 S101447_02833 S101447_02833 S101447_02833 108715 109098 - hypothetical protein gene gene2832 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02833 S101447_02834 S101447_02834 S101447_02834 109125 109604 - hypothetical protein gene gene2833 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02834 S101447_02835 S101447_02835 S101447_02835 109822 110652 + hypothetical protein gene gene2834 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02835 S101447_02836 S101447_02836 S101447_02836 111214 112101 + hypothetical protein gene gene2835 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02836 S101447_02837 S101447_02837 S101447_02837 112236 112871 + hypothetical protein gene gene2836 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02837 S101447_02838 S101447_02838 S101447_02838 112876 113856 + hypothetical protein gene gene2837 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02838 S101447_02839 S101447_02839 S101447_02839 113856 115091 + hypothetical protein gene gene2838 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02839 S101447_02840 S101447_02840 S101447_02840 115166 116272 + hypothetical protein gene gene2839 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02840 S101447_02841 S101447_02841 S101447_02841 116348 116884 + hypothetical protein gene gene2840 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02841 S101447_02842 S101447_02842 S101447_02842 116976 117158 + hypothetical protein gene gene2841 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02842 S101447_02843 S101447_02843 S101447_02843 117140 117415 + hypothetical protein gene gene2842 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02843 S101447_02844 S101447_02844 S101447_02844 117567 118055 + hypothetical protein gene gene2843 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02844 S101447_02845 S101447_02845 S101447_02845 118453 118821 + hypothetical protein gene gene2844 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02845 S101447_02846 S101447_02846 S101447_02846 118928 119983 + hypothetical protein gene gene2845 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02846 S101447_02847 S101447_02847 S101447_02847 119950 121146 + hypothetical protein gene gene2846 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02847 S101447_02848 S101447_02848 S101447_02848 121369 121665 - Putative RelE-like toxin protein Plasmid%3B Toxin%3B Toxic component of a toxin-antitoxin (TA) module%3B Belongs to the RelE toxin family gene gene2847 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02848 S101447_02849 S101447_02849 S101447_02849 121646 121915 - Antitoxin RelB DNA-binding%3B Repressor%3B Stress response%3B Transcription%3B Transcription regulation%3B Antitoxin component of a type II toxin-antitoxin (TA) module. Counteracts the effect of cognate toxin RelE via direct protein-protein interaction%2C preventing RelE from entering the ribosome A site and thus inhibiting its endoribonuclease activity. An autorepressor of relBE operon transcription. 2 RelB dimers bind to 2 operator sequence%3B DNA-binding and repression is stronger when complexed with toxin/corepressor RelE by conditional cooperativity (PubMed:18501926%2C PubMed:22981948). Increased transcription rate of relBE and activation of relE is consistent with a lower level of RelB in starved cells due to degradation of RelB by protease Lon%3B Seems to be a principal mediator of cell death in liquid media%3B Belongs to the RelB/DinJ antitoxin family gene gene2848 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02849 S101447_02850 S101447_02850 S101447_02850 122611 123069 + hypothetical protein gene gene2849 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02850 S101447_02851 S101447_02851 S101447_02851 123062 124096 + hypothetical protein gene gene2850 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02851 S101447_02852 S101447_02852 S101447_02852 124093 125259 + Twitching motility protein ATP-binding%3B Cytoplasm%3B Fimbrium biogenesis%3B Nucleotide-binding%3B Transport%3B May be involved in pilus retraction. Belongs to the GSP E family gene gene2851 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02852 S101447_02853 S101447_02853 S101447_02853 125259 125507 + hypothetical protein gene gene2852 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02853 S101447_02854 S101447_02854 S101447_02854 125504 125938 + hypothetical protein gene gene2853 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02854 S101447_02855 S101447_02855 S101447_02855 125938 126453 + hypothetical protein gene gene2854 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02855 S101447_02856 S101447_02856 S101447_02856 126450 127598 + hypothetical protein gene gene2855 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02856 S101447_02857 S101447_02857 S101447_02857 127611 128243 + hypothetical protein gene gene2856 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02857 S101447_02858 S101447_02858 S101447_02858 128247 130598 + hypothetical protein gene gene2857 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02858 S101447_02859 S101447_02859 S101447_02859 130595 131191 + hypothetical protein gene gene2858 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02859 S101447_02860 S101447_02860 S101447_02860 131228 131887 + hypothetical protein gene gene2859 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02860 S101447_02861 S101447_02861 S101447_02861 131897 132187 - hypothetical protein gene gene2860 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02861 S101447_02862 S101447_02862 S101447_02862 132437 135643 - hypothetical protein gene gene2861 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02862 S101447_02863 S101447_02863 S101447_02863 135640 135948 - hypothetical protein gene gene2862 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02863 S101447_02864 S101447_02864 S101447_02864 136065 137807 - hypothetical protein gene gene2863 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02864 S101447_02865 S101447_02865 S101447_02865 138001 138588 + resolvase DNA integration%3B DNA recombination%3B DNA-binding%3B Plasmid%3B Transposable element%3B Resolvase catalyzes the resolution (a site-specific recombination) of the cointegrated replicon to yield the final transposition products%3B Belongs to the site-specific recombinase resolvase family%3B Contains 1 resolvase/invertase-type recombinase catalytic domain gene gene2864 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02865 S101447_02866 S101447_02866 S101447_02866 138925 139509 - hypothetical protein gene gene2865 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02866 S101447_02867 S101447_02867 S101447_02867 139911 140627 + hypothetical protein gene gene2866 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02867 S101447_02868 S101447_02868 S101447_02868 140743 141591 + hypothetical protein gene gene2867 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02868 S101447_02869 S101447_02869 S101447_02869 141594 142058 + hypothetical protein gene gene2868 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02869 S101447_02870 S101447_02870 S101447_02870 142161 142970 + hypothetical protein gene gene2869 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02870 S101447_02871 S101447_02871 S101447_02871 142983 143387 + hypothetical protein gene gene2870 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02871 S101447_02872 S101447_02872 S101447_02872 143444 143743 - hypothetical protein gene gene2871 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02872 S101447_02873 S101447_02873 S101447_02873 143794 143994 - hypothetical protein gene gene2872 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02873 S101447_02874 S101447_02874 mazF mazF 144051 144401 - Endoribonuclease MazF DNA-binding%3B Endonuclease%3B Hydrolase%3B Nuclease%3B Repressor%3B RNA-binding%3B Toxin%3B Transcription%3B Transcription regulation%3B Toxic component of a type II toxin-antitoxin (TA) module. MazF is a sequence-specific endoribonuclease that inhibits protein synthesis and induces bacterial stasis. It is very stable%2C single-strand specific and cleavage is independent of the ribosome. The endoribonuclease activity (a toxin) is inhibited by the labile cognate antitoxin MazE. Toxicity results when the levels of MazE decrease in the cell%2C leading to mRNA degradation. Both MazE and MazE-MazF bind to the promoter region of the mazE- mazF operon to inhibit their transcription%3B Belongs to the PemK/MazF family%3B KEGG: cch:Cag_0429 mRNA interferase MazF%3B Acting on ester bonds gene gene2873 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02874 S101447_02875 S101447_02875 S101447_02875 144382 144624 - Antitoxin MazE DNA-binding%3B Antitoxin component of a type II toxin-antitoxin (TA) module. Labile antitoxin that binds to its cognate MazF endoribonuclease toxin and neutralizes its activity. Both MazE and MazE-MazF bind to the promoter region of the mazE-mazF operon to inhibit their transcription%3B Belongs to the PemI family%3B Contains 1 SpoVT-AbrB domain gene gene2874 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02875 S101447_02876 S101447_02876 S101447_02876 144735 145043 - hypothetical protein gene gene2875 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02876 S101447_02877 S101447_02877 S101447_02877 145040 145312 - hypothetical protein gene gene2876 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02877 S101447_02878 S101447_02878 S101447_02878 145385 145801 - hypothetical protein gene gene2877 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02878 S101447_02879 S101447_02879 S101447_02879 145798 146232 - hypothetical protein gene gene2878 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02879 S101447_02880 S101447_02880 S101447_02880 146296 146793 - Single-stranded DNA-binding protein DNA damage%3B DNA recombination%3B DNA repair%3B DNA replication%3B DNA-binding%3B Plays an important role in DNA replication%2C recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism%3B Contains 1 SSB domain gene gene2879 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02880 S101447_02881 S101447_02881 S101447_02881 147554 147700 - hypothetical protein gene gene2880 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02881 S101447_02882 S101447_02882 S101447_02882 148050 148730 - hypothetical protein gene gene2881 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02882 S101447_02883 S101447_02883 S101447_02883 149285 149635 + hypothetical protein gene gene2882 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02883 S101447_02884 S101447_02884 S101447_02884 149678 149800 - hypothetical protein gene gene2883 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02884 S101447_02885 S101447_02885 S101447_02885 149797 150015 - hypothetical protein gene gene2884 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02885 S101447_02886 S101447_02886 S101447_02886 150146 150562 - hypothetical protein gene gene2885 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02886 S101447_02887 S101447_02887 S101447_02887 150552 150797 - hypothetical protein gene gene2886 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02887 S101447_02888 S101447_02888 S101447_02888 151298 151711 + hypothetical protein gene gene2887 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02888 S101447_02889 S101447_02889 S101447_02889 151657 152466 + Putative MucR family transcriptional regulatory protein DNA-binding%3B Plasmid%3B Transcription%3B Transcription regulation%3B Belongs to the ros/MucR family gene gene2888 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02889 S101447_02890 S101447_02890 S101447_02890 152560 152751 + hypothetical protein gene gene2889 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02890 S101447_02891 S101447_02891 S101447_02891 152776 152973 + hypothetical protein gene gene2890 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02891 S101447_02892 S101447_02892 S101447_02892 153430 154815 - hypothetical protein gene gene2891 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02892 S101447_02893 S101447_02893 S101447_02893 154873 155349 - hypothetical protein gene gene2892 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02893 S101447_02894 S101447_02894 S101447_02894 155623 155913 - hypothetical protein gene gene2893 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02894 S101447_02895 S101447_02895 S101447_02895 155947 156348 - hypothetical protein gene gene2894 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02895 S101447_02896 S101447_02896 S101447_02896 156293 156460 - hypothetical protein gene gene2895 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02896 S101447_02897 S101447_02897 S101447_02897 156499 156876 - hypothetical protein gene gene2896 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02897 S101447_02898 S101447_02898 S101447_02898 157049 157321 + hypothetical protein gene gene2897 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02898 S101447_02899 S101447_02899 S101447_02899 157321 157923 + hypothetical protein gene gene2898 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02899 S101447_02900 S101447_02900 S101447_02900 157878 158513 - hypothetical protein gene gene2899 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02900 S101447_02901 S101447_02901 S101447_02901 158575 158940 - hypothetical protein gene gene2900 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02901 S101447_02902 S101447_02902 S101447_02902 159343 161340 - hypothetical protein gene gene2901 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02902 S101447_02903 S101447_02903 S101447_02903 161500 162135 + resolvase DNA integration%3B DNA recombination%3B DNA-binding%3B Plasmid%3B Transposable element%3B Resolvase catalyzes the resolution (a site-specific recombination) of the cointegrated replicon to yield the final transposition products%3B Belongs to the site-specific recombinase resolvase family%3B Contains 1 resolvase/invertase-type recombinase catalytic domain gene gene2902 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02903 S101447_02904 S101447_02904 S101447_02904 162702 164759 - DNA helicase ATP-binding%3B DNA damage%3B DNA repair%3B DNA-binding%3B Helicase%3B Hydrolase%3B Nucleotide-binding%3B DNA helicase used for plasmid rolling-circle replication and also involved in UV repair. Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B Contains 1 uvrD-like helicase C-terminal domain%3B KEGG: goh:B932_3634 DNA helicase II / ATP-dependent DNA helicase PcrA gene gene2903 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02904 S101447_02905 S101447_02905 S101447_02905 164756 165445 - hypothetical protein gene gene2904 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02905 S101447_02906 S101447_02906 S101447_02906 165450 166628 - hypothetical protein gene gene2905 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02906 S101447_02907 S101447_02907 S101447_02907 166821 167339 - hypothetical protein gene gene2906 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02907 S101447_02908 S101447_02908 S101447_02908 167383 167766 - hypothetical protein gene gene2907 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02908 S101447_02909 S101447_02909 S101447_02909 167767 168672 - DNA primase TraC Alternative initiation%3B DNA replication%3B DNA-directed RNA polymerase%3B Nucleotidyltransferase%3B Plasmid%3B Transcription%3B Transferase%3B Required for autonomous replication in E. coli. Transferred into the recipient cell during bacterial conjugation. Catalyzes the synthesis of short oligoribonucleotide primers with CpA or pCpA at their 5'-termini on a single-stranded template DNA. Contains 1 Toprim domain gene gene2908 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02909 S101447_02910 S101447_02910 S101447_02910 168696 168857 - hypothetical protein gene gene2909 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02910 S101447_02911 S101447_02911 S101447_02911 169228 169599 - hypothetical protein gene gene2910 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02911 S101447_02912 S101447_02912 S101447_02912 169832 170233 - hypothetical protein gene gene2911 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02912 S101447_02913 S101447_02913 S101447_02913 170471 170962 - hypothetical protein gene gene2912 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02913 S101447_02914 S101447_02914 S101447_02914 171037 172953 - Nucleoid occlusion protein Cell cycle%3B Cell division%3B Cytoplasm%3B DNA-binding%3B Septation%3B Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid%2C especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid%2C which would cause chromosome breakage%3B Belongs to the ParB family gene gene2913 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02914 S101447_02915 S101447_02915 S101447_02915 173142 178268 - hypothetical protein gene gene2914 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02915 S101447_02916 S101447_02916 S101447_02916 178684 179358 + hypothetical protein gene gene2915 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02916 S101447_02917 S101447_02917 S101447_02917 179355 180053 + hypothetical protein gene gene2916 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02917 S101447_02918 S101447_02918 S101447_02918 180310 180618 - hypothetical protein gene gene2917 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02918 S101447_02919 S101447_02919 S101447_02919 180618 181091 - uncharacterized protein Plasmid%3B Transposable element%3B Transposition%3B To transposase of insertion sequence IS6501 gene gene2918 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02919 S101447_02920 S101447_02920 S101447_02920 181652 182575 - hypothetical protein gene gene2919 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02920 S101447_02921 S101447_02921 S101447_02921 183067 184557 - hypothetical protein gene gene2920 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02921 S101447_02922 S101447_02922 S101447_02922 184810 185145 + hypothetical protein gene gene2921 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02922 S101447_02923 S101447_02923 S101447_02923 185809 186078 + hypothetical protein gene gene2922 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02923 S101447_02924 S101447_02924 S101447_02924 186367 186531 + hypothetical protein gene gene2923 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02924 S101447_02925 S101447_02925 S101447_02925 186634 187185 + hypothetical protein gene gene2924 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02925 S101447_02926 S101447_02926 S101447_02926 187451 187786 + hypothetical protein gene gene2925 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02926 S101447_02927 S101447_02927 S101447_02927 188512 189069 - Small heat shock protein HspA Stress response%3B Belongs to the small heat shock protein (HSP20) family gene gene2926 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02927 S101447_02928 S101447_02928 S101447_02928 189072 190112 + Putative transposase y4pF/y4sB DNA recombination%3B DNA-binding%3B Plasmid%3B Transposable element%3B Transposition%3B Belongs to the transposase 20 family gene gene2927 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02928 S101447_02929 S101447_02929 S101447_02929 190656 191678 - putative family 20 transposase DNA recombination%3B DNA-binding%3B Transposable element%3B Transposition%3B Required for the transposition of an insertion element%3B Belongs to the transposase 20 family gene gene2928 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02929 S101447_02930 S101447_02930 S101447_02930 191991 192221 + hypothetical protein gene gene2929 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02930 S101447_02931 S101447_02931 S101447_02931 192341 193417 - Transposase InsH for insertion sequence element IS5R DNA recombination%3B DNA-binding%3B Transposable element%3B Transposition%3B Involved in the transposition of the insertion sequence IS5. Belongs to the transposase 11 family gene gene2930 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02931 S101447_02932 S101447_02932 S101447_02932 193549 194751 - hypothetical protein gene gene2931 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02932 S101447_02933 S101447_02933 S101447_02933 194738 195037 - hypothetical protein gene gene2932 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02933 S101447_02934 S101447_02934 S101447_02934 195804 198026 - hypothetical protein gene gene2933 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02934 S101447_02935 S101447_02935 S101447_02935 198103 198633 - hypothetical protein gene gene2934 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02935 S101447_02936 S101447_02936 S101447_02936 198685 198864 + hypothetical protein gene gene2935 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02936 S101447_02937 S101447_02937 S101447_02937 198962 199954 + putative GPI-anchored protein Cell membrane%3B Glycoprotein%3B GPI-anchor%3B Lipoprotein%3B Membrane%3B Signal. gene gene2936 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02937 S101447_02938 S101447_02938 S101447_02938 200198 200425 + hypothetical protein gene gene2937 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02938 S101447_02939 S101447_02939 S101447_02939 200463 201353 - Transposase for insertion sequence element IS3411 DNA recombination%3B DNA-binding%3B Transposable element%3B Transposition%3B Involved in the transposition of the insertion sequence. Contains 1 integrase catalytic domain gene gene2938 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02939 S101447_02940 S101447_02940 S101447_02940 201350 201673 - Insertion element IS629 uncharacterized 12 kDa protein Transposable element%3B Belongs to the transposase 8 family gene gene2939 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02940 S101447_02941 S101447_02941 S101447_02941 201725 202516 - hypothetical protein gene gene2940 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02941 S101447_02942 S101447_02942 S101447_02942 202762 203097 + hypothetical protein gene gene2941 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02942 S101447_02943 S101447_02943 S101447_02943 203680 203871 + hypothetical protein gene gene2942 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02943 S101447_02944 S101447_02944 S101447_02944 204386 204877 - hypothetical protein gene gene2943 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02944 S101447_02945 S101447_02945 S101447_02945 204879 205346 - Protein aau3 2Fe-2S%3B DNA-binding%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Required for growth utilizing PHB cycle intermediates. Contains 1 HTH rrf2-type DNA-binding domain gene gene2944 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02945 S101447_02946 S101447_02946 S101447_02946 205420 206736 + Nitric oxide dioxygenase Heme%3B Iron%3B Metal-binding%3B Oxygen transport%3B Transport%3B This protein functions as a terminal oxidase. Belongs to the globin family%3B KEGG: acr:Acry_0660 nitric oxide dioxygenase gene gene2945 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02946 S101447_02947 S101447_02947 norB norB 206828 207298 + Nitric-oxide reductase (cytochrome c) KEGG: lpn:lpg2236 nitric oxide reductase subunit B gene gene2946 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02947 S101447_02948 S101447_02948 S101447_02948 207333 208160 - Low calcium response locus protein Plasmid%3B overlaps another CDS with the same product name gene gene2947 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02948 S101447_02949 S101447_02949 S101447_02949 208157 208420 - Low calcium response locus protein Plasmid%3B Belongs to the transposase 8 family%3B overlaps another CDS with the same product name gene gene2948 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02949 S101447_02950 S101447_02950 S101447_02950 208629 208760 + hypothetical protein gene gene2949 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02950 S101447_02951 S101447_02951 S101447_02951 208818 210203 + hypothetical protein gene gene2950 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02951 S101447_02952 S101447_02952 S101447_02952 210394 210687 + hypothetical protein gene gene2951 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02952 S101447_02953 S101447_02953 S101447_02953 210684 210956 + hypothetical protein gene gene2952 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02953 S101447_02954 S101447_02954 S101447_02954 210970 211185 - hypothetical protein gene gene2953 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02954 S101447_02955 S101447_02955 S101447_02955 211221 211799 + hypothetical protein gene gene2954 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02955 S101447_02956 S101447_02956 S101447_02956 211834 212022 + hypothetical protein gene gene2955 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02956 S101447_02957 S101447_02957 S101447_02957 212304 213689 + hypothetical protein gene gene2956 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02957 S101447_02958 S101447_02958 S101447_02958 213916 214209 + Alcohol dehydrogenase Cytoplasm%3B NADP%3B Oxidoreductase%3B Catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA. Is essential for growth with 3-hydroxypropanoate as a sole carbon source. Restores acrylate resistance when expressed in the E. coli strain K12 acuI deletion%3B Belongs to the zinc-containing alcohol dehydrogenase family. Acrylyl-CoA reductase subfamily%3B KEGG: cgl:NCgl2449 alcohol dehydrogenase gene gene2957 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02958 S101447_02959 S101447_02959 S101447_02959 214241 214546 - putative HTH-type transcriptional regulator YbzH DNA-binding%3B Transcription%3B Transcription regulation%3B Contains 1 HTH arsR-type DNA-binding domain gene gene2958 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02959 S101447_02960 S101447_02960 S101447_02960 214665 215789 - N-ethylmaleimide reductase Flavoprotein%3B FMN%3B NADP%3B Oxidoreductase%3B Catalyzes the reduction of N-ethylmaleimide (NEM) to N- ethylsuccinimide%3B Belongs to the NADH:flavin oxidoreductase/NADH oxidase family%3B KEGG: abr:ABTJ_p2063 N-ethylmaleimide reductase%3B Oxidoreductases gene gene2959 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02960 S101447_02961 S101447_02961 S101447_02961 216102 216797 - 6-phosphogluconolactonase KEGG: cfi:Celf_1869 6-phosphogluconolactonase gene gene2960 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02961 S101447_02962 S101447_02962 S101447_02962 216867 217754 + HTH-type transcriptional regulator NimR DNA-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Negatively regulates expression of the nimT operon and its own expression. Acts by binding to the nimR-nimT intergenic region%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene2961 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02962 S101447_02963 S101447_02963 S101447_02963 217793 218416 - hypothetical protein gene gene2962 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02963 S101447_02964 S101447_02964 rutB rutB 218521 219090 + Peroxyureidoacrylate/ureidoacrylate amidohydrolase Hydrolase%3B Plasmid%3B Belongs to the isochorismatase family%3B KEGG: eln:NRG857_04900 ureidoacrylate peracid hydrolase gene gene2963 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02964 S101447_02965 S101447_02965 S101447_02965 219226 220536 + Puromycin resistance protein pur8 Antibiotic biosynthesis%3B Antibiotic resistance%3B Cell membrane%3B Membrane%3B Transmembrane%3B Transmembrane helix%3B Transport%3B May be involved in active puromycin efflux energized by a proton-dependent electrochemical gradient. In addition%2C it could be implicated in secreting N-acetylpuromycin%2C the last intermediate of the puromycin biosynthesis pathway%2C to the environment. Belongs to the major facilitator superfamily. EmrB family gene gene2964 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02965 S101447_02966 S101447_02966 S101447_02966 220642 221721 + hypothetical protein gene gene2965 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02966 S101447_02967 S101447_02967 tehB tehB 221820 222146 - Tellurite methyltransferase KEGG: gan:UMN179_00567 tellurite methyltransferase gene gene2966 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02967 S101447_02968 S101447_02968 S101447_02968 222174 222575 - hypothetical protein gene gene2967 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02968 S101447_02969 S101447_02969 S101447_02969 222726 223202 + hypothetical protein gene gene2968 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02969 S101447_02970 S101447_02970 S101447_02970 223244 223972 + CRP-like cAMP-activated global transcriptional regulator Activator%3B cAMP%3B cAMP-binding%3B DNA-binding%3B Kinase%3B Nucleotide-binding%3B Repressor%3B Transcription%3B Transcription regulation%3B Transferase%3B Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites%2C causing DNA- bending%2C to regulate transcription. cAMP improves binding to specific DNA sequences%2C probably by altering protein conformation. Involved in the regulation of gntP and gntK genes%2C which are involved in gluconate metabolism (PubMed:16385030). May form dimers which bind to the aceB promoter region in the presence of cAMP and repress the glyoxylate bypass genes (PubMed:15150232). It could be a positive regulator of rpf2 gene expression during growth on acetate as the sole carbon source%2C however because the cytosolic cAMP level is elevated in the presence of glucose and low upon growth on acetate%2C it is conceivable that it is unable to function as an activator under acetate conditions (PubMed:18355281)%3B Contains 1 cyclic nucleotide-binding domain%3B Contains 1 HTH crp-type DNA-binding domain gene gene2969 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02970 S101447_02971 S101447_02971 S101447_02971 224266 225486 + Nitrate transporter Cell membrane%3B Membrane%3B Nitrate assimilation%3B Transmembrane%3B Transmembrane helix%3B Transport%3B May function as a nitrate transporter%3B Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2. A. 1. 8) family gene gene2970 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02971 S101447_02972 S101447_02972 S101447_02972 225515 227197 + hypothetical protein gene gene2971 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02972 S101447_02973 S101447_02973 S101447_02973 227255 227449 - hypothetical protein gene gene2972 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02973 S101447_02974 S101447_02974 nirB nirB 227570 230467 + Nitrite reductase (NADH) 4Fe-4S%3B FAD%3B Flavoprotein%3B Heme%3B Iron%3B Iron-sulfur%3B Metal-binding%3B NAD%3B Nitrate assimilation%3B Oxidoreductase%3B Belongs to the nitrite and sulfite reductase 4Fe-4S domain family%3B KEGG: pstt:CH92_09890 nitrite reductase (NADH) large subunit gene gene2973 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02974 S101447_02975 S101447_02975 S101447_02975 230475 234428 + Assimilatory sulfite reductase (NADPH) 4Fe-4S%3B Electron transport%3B Iron%3B Iron-sulfur%3B Metal-binding%3B Molybdenum%3B Nitrate assimilation%3B Oxidoreductase%3B Secreted%3B Signal%3B Transport%3B Catalytic subunit of the nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC. Essential function for nitrate assimilation and may have a role in anaerobic metabolism%3B Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily%3B Contains 1 4Fe-4S Mo/W bis-MGD-type domain%3B KEGG: bma:BMAA1084 sulfite reductase (NADPH) flavoprotein alpha-component gene gene2974 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02975 S101447_02976 S101447_02976 S101447_02976 234428 235048 + putative transcriptional regulatory protein pdtaR Phosphoprotein%3B Transcription%3B Transcription antitermination%3B Transcription regulation%3B Two-component regulatory system%3B Member of the two-component regulatory system pdtaR/pdtaS%3B Contains 1 ANTAR domain%3B Contains 1 response regulatory domain gene gene2975 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02976 S101447_02977 S101447_02977 S101447_02977 235045 236019 + Nitrate transport protein NrtA Cell inner membrane%3B Cell membrane%3B Membrane%3B Nitrate assimilation%3B Signal%3B Transport%3B Essential component of the nitrate-transporting system. May be the substrate-binding protein. Belongs to the CmpA/NrtA family gene gene2976 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02977 S101447_02978 S101447_02978 S101447_02978 236255 236494 - Insertion element IS476 uncharacterized 39.2 kDa protein Transposable element%3B Contains 1 integrase catalytic domain gene gene2977 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02978 S101447_02979 S101447_02979 S101447_02979 236467 237081 - Low calcium response locus protein Plasmid%3B overlaps another CDS with the same product name gene gene2978 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02979 S101447_02980 S101447_02980 S101447_02980 237078 237341 - Low calcium response locus protein Plasmid%3B Belongs to the transposase 8 family%3B overlaps another CDS with the same product name gene gene2979 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02980 S101447_02981 S101447_02981 S101447_02981 237457 237768 + Fe(2+)/Mn(2+) transporter pcl1 Endoplasmic reticulum%3B Golgi apparatus%3B Membrane%3B Phosphoprotein%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Vacuole%3B Has a role in both calcium and manganese homeostasis. Involved in the transfer of iron and Mn(2+) from the cytosol to the vacuole for storage of these metals (By similarity)%3B Belongs to the CCC1 family gene gene2980 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02981 S101447_02982 S101447_02982 S101447_02982 237789 238199 + Arsenate reductase (glutaredoxin) KEGG: nha:Nham_4431 arsenate reductase%3B overlaps another CDS with the same product name gene gene2981 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02982 S101447_02983 S101447_02983 S101447_02983 238196 238618 + Arsenate reductase (glutaredoxin) Arsenical resistance%3B Oxidoreductase%3B Plasmid%3B Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance. Belongs to the ArsC family%3B KEGG: pes:SOPEG_3771 arsenate reductase%3B overlaps another CDS with the same product name gene gene2982 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02983 S101447_02984 S101447_02984 S101447_02984 238618 239913 + Arsenical pump membrane protein Arsenical resistance%3B Cell membrane%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Involved in arsenical resistance. Thought to form the channel of an arsenite pump. Belongs to the ArsB family gene gene2983 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02984 S101447_02985 S101447_02985 S101447_02985 239913 240590 + NADPH-dependent FMN reductase ArsH Flavoprotein%3B FMN%3B NADP%3B Nucleotide-binding%3B Oxidoreductase%3B Has NADPH-dependent FMN reductase activity and high NADPH-dependent ferric reductase activity with highest activity for Fe(3+) as substrate. No activity with NADH%2C iron trichloride%2C Cu(2+) or Ag(+). May be involved in cytosolic ferric iron assimilation as an NADPH-dependent ferric reductase in vivo%3B Belongs to the ArsH family gene gene2984 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02985 S101447_02986 S101447_02986 S101447_02986 240642 240965 + Insertion element IS629 uncharacterized 12 kDa protein Transposable element%3B Belongs to the transposase 8 family gene gene2985 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02986 S101447_02987 S101447_02987 S101447_02987 240962 241852 + Transposase for insertion sequence element IS3411 DNA recombination%3B DNA-binding%3B Transposable element%3B Transposition%3B Involved in the transposition of the insertion sequence. Contains 1 integrase catalytic domain gene gene2986 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02987 S101447_02988 S101447_02988 S101447_02988 242058 242741 - hypothetical protein gene gene2987 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02988 S101447_02989 S101447_02989 S101447_02989 242741 244003 - Na(+)/H(+) antiporter NhaP Antiport%3B Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Sodium%3B Sodium transport%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Has also weak Li(+)/H(+) antiport activity%3B Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2. A. 36) family gene gene2988 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02989 S101447_02990 S101447_02990 S101447_02990 244135 244428 - mRNA interferase RelE Antibiotic resistance%3B Endonuclease%3B Hydrolase%3B Nuclease%3B Repressor%3B RNA-binding%3B rRNA-binding%3B Stress response%3B Toxin%3B Transcription%3B Transcription regulation%3B Toxic component of a type II toxin-antitoxin (TA) module (PubMed:9767574). A sequence-specific%2C ribosome-dependent mRNA endoribonuclease that inhibits translation during amino acid starvation (the stringent response). In vitro acts by cleaving mRNA with high codon specificity in the ribosomal A site between positions 2 and 3. The stop codon UAG is cleaved at a fast rate while UAA and UGA are cleaved with intermediate and slow rates. In vitro mRNA cleavage can also occur in the ribosomal E site after peptide release from peptidyl-tRNA in the P site as well as on free 30S subunits (PubMed:12526800). In vivo cuts frequently in the first 100 codons%2C most frequently after the second and third base and rarely near the stop codon (PubMed:21324908). Overexpression of RelE results in the inhibition of bacterial growth and a sharp decrease in colony-forming ability which is neutralized by the labile cognate antitoxin RelB. Overexpression also sharply increases persisters (cells that neither grow nor die in the presence of bactericidal agents and are largely responsible for high levels of biofilm tolerance to antimicrobials) (PubMed:15576765). Plays a role in dormancy when expressed in high-density cells in the absence of antitoxin Rel%3B amino acid starvation and an unidentified extracellular factor promote dormancy%2C while expression of antitoxin RelB restores cell culturability (PubMed:22210768). Acts with RelB as a corepressor of relBE transcription%2C considerably increasing the repression of RelB alone. 2 RelB dimers bind to 2 operator sequence%3B DNA- binding and repression is stronger when complexed with toxin/corepressor RelE by conditional cooperativity (PubMed:9767574%2C PubMed:19747491%2C PubMed:18501926%2C PubMed:22981948)%3B Seems to be a principal mediator of cell death in liquid media (PubMed:19707553). Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847)%3B Cross-talk can occur between different TA modules. Ectopic expression of this toxin induces transcription of 7 tested TA modules (dinJ/yafQ%2C hicAB%2C mazEF%2C mqsRA%2C prlF(sohA)/yhaV%2C relBEF and yefM/yoeB) with specific cleavage of the relBEF mRNA produced immediately upstream and within the relB coding sequence. The cleaved mRNA can be translated into RelE%2C leading to a positive feedback cycle of RelE expression. The relBEF operon is required for transcription of the mazEF TA module operon during amino acid starvation%3B Belongs to the RelE toxin family gene gene2989 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02990 S101447_02991 S101447_02991 S101447_02991 244425 244685 - Antitoxin RelB DNA-binding%3B Repressor%3B Stress response%3B Transcription%3B Transcription regulation%3B Antitoxin component of a type II toxin-antitoxin (TA) module. Counteracts the effect of cognate toxin RelE via direct protein-protein interaction%2C preventing RelE from entering the ribosome A site and thus inhibiting its endoribonuclease activity. An autorepressor of relBE operon transcription. 2 RelB dimers bind to 2 operator sequence%3B DNA-binding and repression is stronger when complexed with toxin/corepressor RelE by conditional cooperativity (PubMed:18501926%2C PubMed:22981948). Increased transcription rate of relBE and activation of relE is consistent with a lower level of RelB in starved cells due to degradation of RelB by protease Lon%3B Seems to be a principal mediator of cell death in liquid media%3B Belongs to the RelB/DinJ antitoxin family gene gene2990 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02991 S101447_02992 S101447_02992 srlD srlD 244919 245695 - Sorbitol-6-phosphate 2-dehydrogenase Endoplasmic reticulum%3B Fatty acid biosynthesis%3B Fatty acid metabolism%3B Lipid biosynthesis%3B Lipid metabolism%3B Membrane%3B NADP%3B Oxidoreductase%3B Transmembrane%3B Transmembrane helix%3B Component of the microsomal membrane bound fatty acid elongation system%2C which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: seq:SZO_01750 sorbitol-6-phosphate 2-dehydrogenase gene gene2991 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02992 S101447_02993 S101447_02993 S101447_02993 245768 246310 - DNA-3-methyladenine glycosylase I ATP-binding%3B Glutamine amidotransferase%3B GMP biosynthesis%3B Ligase%3B Nucleotide-binding%3B Purine biosynthesis%3B Repeat%3B Catalyzes the synthesis of GMP from XMP%3B Contains 1 glutamine amidotransferase type-1 domain%3B Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain%3B Contains 3 N-acetyltransferase domains%3B KEGG: sgl:SG1137 DNA-3-methyladenine glycosylase I gene gene2992 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02993 S101447_02994 S101447_02994 lys1 lys1 246376 247401 - Saccharopine dehydrogenase (NAD(+)%2C L-lysine-forming) KEGG: sen:SACE_1566 saccharopine dehydrogenase (NAD+%2C L-lysine forming) gene gene2993 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02994 S101447_02995 S101447_02995 S101447_02995 247391 247792 - Lactoylglutathione lyase KEGG: bme:BMEI0164 lactoylglutathione lyase gene gene2994 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02995 S101447_02996 S101447_02996 S101447_02996 248011 248901 + putative HTH-type transcriptional regulator YqhC DNA-binding%3B Transcription%3B Transcription regulation%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene2995 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02996 S101447_02997 S101447_02997 S101447_02997 249216 250793 - Nif-specific regulatory protein Activator%3B ATP-binding%3B DNA-binding%3B Metal-binding%3B Nitrogen fixation%3B Nucleotide-binding%3B Transcription%3B Transcription regulation%3B Two-component regulatory system%3B Required for activation of most nif operons%2C which are directly involved in nitrogen fixation. Contains 1 GAF domain%3B Contains 1 sigma-54 factor interaction domain gene gene2996 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02997 S101447_02998 S101447_02998 S101447_02998 250895 252598 - hypothetical protein gene gene2997 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02998 S101447_02999 S101447_02999 cynS cynS 252722 253177 - Cyanase Lyase%3B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide%3B Belongs to the cyanase family%3B KEGG: gag:Glaag_0887 cyanate lyase gene gene2998 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_02999 S101447_03000 S101447_03000 S101447_03000 253195 254037 - Taurine import ATP-binding protein TauB ATP-binding%3B Cell inner membrane%3B Cell membrane%3B Hydrolase%3B Membrane%3B Nucleotide-binding%3B Transport%3B Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Taurine importer (TC 3. A. 1. 17. 1) family%3B Contains 1 ABC transporter domain gene gene2999 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03000 S101447_03001 S101447_03001 S101447_03001 254027 254887 - Nitrate transport permease protein NrtB Cell membrane%3B Membrane%3B Nitrate assimilation%3B Transmembrane%3B Transmembrane helix%3B Transport%3B Probably part of a high-affinity binding-protein- dependent transport system for nitrat%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene3000 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03001 S101447_03002 S101447_03002 S101447_03002 254893 256245 - Bicarbonate-binding protein CmpA Cell inner membrane%3B Cell membrane%3B Ion transport%3B Membrane%3B Signal%3B Transport%3B Part of the ABC transporter complex CmpABCD involved in bicarbonate transport. Binds bicarbonate with high affinity%3B Belongs to the CmpA/NrtA family gene gene3001 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03002 S101447_03003 S101447_03003 S101447_03003 256250 257602 - Rubredoxin--NAD(+) reductase Electron transport%3B Iron%3B Metal-binding%3B Transport%3B Rubredoxin is a small nonheme%2C iron protein lacking acid-labile sulfide. Its single Fe%2C chelated to 4 Cys%2C functions as an electron acceptor and may also stabilize the conformation of the molecule. Belongs to the rubredoxin family%3B Contains 1 rubredoxin-like domain%3B KEGG: prh:LT40_07165 rubredoxin-NAD+ reductase gene gene3002 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03003 S101447_03004 S101447_03004 S101447_03004 257599 258723 - hypothetical protein gene gene3003 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03004 S101447_03005 S101447_03005 S101447_03005 258769 259311 - hypothetical protein gene gene3004 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03005 S101447_03006 S101447_03006 S101447_03006 260227 260589 - HTH-type transcriptional activator HxlR Activator%3B DNA-binding%3B Transcription%3B Transcription regulation%3B Positive regulator of hxlAB expression. Contains 1 HTH hxlR-type DNA-binding domain gene gene3005 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03006 S101447_03007 S101447_03007 S101447_03007 260705 261829 + NADPH dehydrogenase Flavoprotein%3B FMN%3B NADP%3B Oxidoreductase%3B Oxidizes beta-NADH%2C beta-NADPH%2C and alpha-NADPH. Belongs to the NADH:flavin oxidoreductase/NADH oxidase family%3B KEGG: gxl:H845_3439 N-ethylmaleimide reductase%3B Oxidoreductases gene gene3006 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03007 S101447_03008 S101447_03008 S101447_03008 261846 263216 + Succinate-semialdehyde dehydrogenase (NAD(P)(+)) NADP%3B Oxidoreductase%3B Catalyzes the NADP(+) dependent oxidation of succinate semialdehyde to succinate%3B Belongs to the aldehyde dehydrogenase family%3B KEGG: gxl:H845_3438 succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase gene gene3007 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03008 S101447_03009 S101447_03009 S101447_03009 263481 264380 - HTH-type transcriptional regulator YofA Cell cycle%3B Cell division%3B Cytoplasm%3B DNA-binding%3B Septation%3B Transcription%3B Transcription regulation%3B Regulates expression of the cell division protein ftsW%2C and is essential for cell viability during stationary phase%3B Contains 1 HTH lysR-type DNA-binding domain gene gene3008 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03009 S101447_03010 S101447_03010 metE metE 264701 265729 - 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase Amino-acid biosynthesis%3B Cytoplasm%3B Isopeptide bond%3B Metal-binding%3B Methionine biosynthesis%3B Methyltransferase%3B Transferase%3B Ubl conjugation%3B Zinc%3B Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation%3B Belongs to the vitamin-B12 independent methionine synthase family%3B KEGG: eca:ECA3126 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase gene gene3009 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03010 S101447_03011 S101447_03011 S101447_03011 265757 266740 - hypothetical protein gene gene3010 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03011 S101447_03012 S101447_03012 S101447_03012 266759 267073 - hypothetical protein gene gene3011 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03012 S101447_03013 S101447_03013 S101447_03013 267137 267370 + hypothetical protein gene gene3012 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03013 S101447_03014 S101447_03014 S101447_03014 267682 268428 + Chlorophyllide a oxygenase%2C chloroplastic 2Fe-2S%3B Alternative splicing%3B Chlorophyll biosynthesis%3B Chloroplast%3B Coiled coil%3B Iron%3B Iron-sulfur%3B Membrane%3B Metal-binding%3B NADP%3B Oxidoreductase%3B Plastid%3B Thylakoid%3B Transit peptide%3B Catalyzes a two-step oxygenase reaction involved in the synthesis of chlorophyll b. Acts specifically on the non- esterified chlorophyllide a and not on chlorophyll a%3B Contains 1 Rieske domain%3B KEGG: bxe:Bxe_B0203 null%3B Acting on paired donors%2C with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O(2) gene gene3013 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03014 S101447_03015 S101447_03015 S101447_03015 268480 268815 + hypothetical protein gene gene3014 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03015 S101447_03016 S101447_03016 S101447_03016 268799 269473 + Transposase for insertion sequence element IS3411 DNA recombination%3B DNA-binding%3B Transposable element%3B Transposition%3B Involved in the transposition of the insertion sequence. Contains 1 integrase catalytic domain gene gene3015 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03016 S101447_03017 S101447_03017 S101447_03017 269665 270744 + hypothetical protein gene gene3016 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03017 S101447_03018 S101447_03018 S101447_03018 270734 271069 + Transposase for insertion sequence element IS629 DNA recombination%3B DNA-binding%3B Transposable element%3B Transposition%3B Involved in the transposition of the insertion sequence. Contains 1 integrase catalytic domain gene gene3017 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03018 S101447_03019 S101447_03019 S101447_03019 271144 272238 + Arsenical pump membrane protein Arsenical resistance%3B Cell inner membrane%3B Cell membrane%3B Membrane%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Involved in arsenical resistance. Thought to form the channel of an arsenite pump gene gene3018 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03019 S101447_03020 S101447_03020 S101447_03020 272238 272960 + NADPH-dependent FMN reductase ArsH Flavoprotein%3B FMN%3B NADP%3B Nucleotide-binding%3B Oxidoreductase%3B Has NADPH-dependent FMN reductase activity and high NADPH-dependent ferric reductase activity with highest activity for Fe(3+) as substrate. No activity with NADH%2C iron trichloride%2C Cu(2+) or Ag(+). May be involved in cytosolic ferric iron assimilation as an NADPH-dependent ferric reductase in vivo%3B Belongs to the ArsH family gene gene3019 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03020 S101447_03021 S101447_03021 S101447_03021 272969 274024 + Flavin-containing monooxygenase FMO GS-OX-like FAD%3B Flavoprotein%3B Monooxygenase%3B NADP%3B Oxidoreductase%3B Catalyzes the conversion of methylthioalkyl glucosinolates of any chain length into methylsulfinylalkyl glucosinolates%3B Belongs to the FMO family gene gene3020 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03021 S101447_03022 S101447_03022 S101447_03022 274184 275284 - hypothetical protein gene gene3021 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03022 S101447_03023 S101447_03023 S101447_03023 275764 276432 + uncharacterized protein KEGG: ppun:PP4_19240 5-methylcytosine-specific restriction enzyme B%3B Endodeoxyribonucleases producing 5'-phosphomonoesters gene gene3022 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03023 S101447_03024 S101447_03024 S101447_03024 276789 277862 - Artemisinic aldehyde Delta(11(13)) reductase Cytoplasm%3B Flavoprotein%3B FMN%3B NADP%3B Oxidoreductase%3B Involved in the biosynthesis of the antimalarial endoperoxide artemisinin by catalyzing the double bond reduction of (11R)-dihydroartemisinic aldehyde to produce artemisinic aldehyde. Also able to reduce artemisinic alcohol and artemisinic acid to a lesser extent%3B Belongs to the NADH:flavin oxidoreductase/NADH oxidase family%3B KEGG: pao:Pat9b_4657 N-ethylmaleimide reductase%3B Oxidoreductases gene gene3023 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03024 S101447_03025 S101447_03025 S101447_03025 278190 278588 - Mercuric resistance operon regulatory protein Activator%3B DNA-binding%3B Mercuric resistance%3B Mercury%3B Metal-binding%3B Plasmid%3B Repressor%3B Transcription%3B Transcription regulation%3B Transposable element%3B Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator regio%3B when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator%2C while remaining bound to the mer site. Contains 1 HTH merR-type DNA-binding domain gene gene3024 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03025 S101447_03026 S101447_03026 S101447_03026 278662 279312 + hypothetical protein gene gene3025 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03026 S101447_03027 S101447_03027 S101447_03027 279305 280747 + hypothetical protein gene gene3026 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03027 S101447_03028 S101447_03028 S101447_03028 280744 281778 + hypothetical protein gene gene3027 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03028 S101447_03029 S101447_03029 S101447_03029 281778 284912 + Nickel and cobalt resistance protein CnrA Cell inner membrane%3B Cell membrane%3B Cobalt%3B Membrane%3B Nickel%3B Plasmid%3B Transmembrane%3B Transmembrane helix%3B Transport%3B The products of the genes cnrA%2C cnrB%2C and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni(2+) and Co(2+). The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter. Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene3028 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03029 S101447_03030 S101447_03030 S101447_03030 284939 285136 - hypothetical protein gene gene3029 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03030 S101447_03031 S101447_03031 S101447_03031 285854 287467 + Site-specific DNA-methyltransferase (adenine-specific) Methyltransferase%3B Plasmid%3B Restriction system%3B S-adenosyl-L-methionine%3B Transferase%3B Methylation of specific adenine residue%3B required for both restriction and modification activities%3B Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: apt:APA01_41890 type I restriction enzyme M protein gene gene3030 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03031 S101447_03032 S101447_03032 S101447_03032 287464 287868 + uncharacterized protein gene gene3031 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03032 S101447_03033 S101447_03033 S101447_03033 287865 288182 + Type I site-specific deoxyribonuclease KEGG: lfc:LFE_0353 type I restriction enzyme%2C S subunit%3B overlaps another CDS with the same product name gene gene3032 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03033 S101447_03034 S101447_03034 S101447_03034 288182 289477 + Type I site-specific deoxyribonuclease DNA-binding%3B Repeat%3B Restriction system%3B The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. Subunit S dictates DNA sequences specificity (By similarity)%3B Belongs to the type-I restriction system S methylase family%3B KEGG: nml:Namu_1103 type I restriction enzyme%2C S subunit%3B overlaps another CDS with the same product name gene gene3033 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03034 S101447_03035 S101447_03035 S101447_03035 289474 292659 + Type I site-specific deoxyribonuclease ATP-binding%3B DNA-binding%3B Hydrolase%3B Nucleotide-binding%3B Restriction system%3B Subunit R is required for both nuclease and ATPase activities%2C but not for modification%3B Belongs to the HsdR family%3B Contains 1 helicase ATP-binding domain%3B KEGG: zmm:Zmob_1744 type I restriction enzyme%2C R subunit%3B overlaps another CDS with the same product name gene gene3034 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03035 S101447_03036 S101447_03036 S101447_03036 292904 293554 + hypothetical protein gene gene3035 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03036 S101447_03037 S101447_03037 S101447_03037 293831 294550 + hypothetical protein gene gene3036 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03037 S101447_03038 S101447_03038 S101447_03038 294608 295102 + hypothetical protein gene gene3037 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03038 S101447_03039 S101447_03039 S101447_03039 295099 295422 + Insertion element IS629 uncharacterized 12 kDa protein Transposable element%3B Belongs to the transposase 8 family gene gene3038 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03039 S101447_03040 S101447_03040 S101447_03040 295419 296309 + Transposase for insertion sequence element IS3411 DNA recombination%3B DNA-binding%3B Transposable element%3B Transposition%3B Involved in the transposition of the insertion sequence. Contains 1 integrase catalytic domain gene gene3039 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03040 S101447_03041 S101447_03041 S101447_03041 296414 297301 + hypothetical protein gene gene3040 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03041 S101447_03042 S101447_03042 S101447_03042 297561 298127 + hypothetical protein gene gene3041 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03042 S101447_03043 S101447_03043 S101447_03043 298682 299182 - Putative MucR family transcriptional regulatory protein DNA-binding%3B Plasmid%3B Transcription%3B Transcription regulation%3B Belongs to the ros/MucR family gene gene3042 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03043 S101447_03044 S101447_03044 S101447_03044 299513 300265 - Nuclease EXOG%2C mitochondrial Endonuclease%3B Hydrolase%3B Membrane%3B Metal-binding%3B Mitochondrion%3B Mitochondrion inner membrane%3B Nuclease%3B Transit peptide%3B Endo/exonuclease with nicking activity towards supercoiled DNA%2C a preference for single-stranded DNA and 5'-3' exonuclease activity%3B Belongs to the DNA/RNA non-specific endonuclease family gene gene3043 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03044 S101447_03045 S101447_03045 S101447_03045 300393 300599 + hypothetical protein gene gene3044 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03045 S101447_03046 S101447_03046 S101447_03046 301116 302594 + hypothetical protein gene gene3045 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03046 S101447_03047 S101447_03047 S101447_03047 302583 302876 - Putative transposase for insertion sequence element IS986/IS6110 DNA recombination%3B DNA-binding%3B Transposable element%3B Transposition%3B Involved in the transposition of the insertion sequence%3B Contains 1 integrase catalytic domain gene gene3046 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03047 S101447_03048 S101447_03048 S101447_03048 302890 304098 - Transposase for insertion sequence element IS1086 DNA recombination%3B DNA-binding%3B Plasmid%3B Transposable element%3B Transposition%3B Required for the transposition of the insertion element%3B Belongs to the transposase IS30 family%3B Contains 1 integrase catalytic domain gene gene3047 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03048 S101447_03049 S101447_03049 S101447_03049 304214 304762 - Transposase for insertion sequence element IS3411 DNA recombination%3B DNA-binding%3B Transposable element%3B Transposition%3B Involved in the transposition of the insertion sequence. Contains 1 integrase catalytic domain gene gene3048 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03049 S101447_03050 S101447_03050 S101447_03050 304812 304919 + DNA-directed DNA polymerase KEGG: gxy:GLX_29700 error-prone DNA polymerase gene gene3049 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03050 S101447_03051 S101447_03051 S101447_03051 304998 305810 + Transposase for insertion sequence element IS1328 DNA recombination%3B DNA-binding%3B Transposable element%3B Transposition%3B Required for the transposition of the insertion element%3B Belongs to the transposase IS1111A/IS1328/IS1533 family gene gene3050 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03051 S101447_03052 S101447_03052 S101447_03052 306025 306417 - Insertion element IS629 uncharacterized 12 kDa protein Transposable element%3B Belongs to the transposase 8 family gene gene3051 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03052 S101447_03053 S101447_03053 S101447_03053 306469 307521 - hypothetical protein gene gene3052 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03053 S101447_03054 S101447_03054 S101447_03054 307726 307995 + Insertion element IS476 uncharacterized 39.2 kDa protein Transposable element%3B Contains 1 integrase catalytic domain gene gene3053 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03054 S101447_03055 S101447_03055 S101447_03055 308281 309243 - hypothetical protein gene gene3054 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03055 S101447_03056 S101447_03056 S101447_03056 309657 311582 + Exodeoxyribonuclease VII Cytoplasm%3B Exonuclease%3B Hydrolase%3B Nuclease%3B Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides%2C which are then degraded further into small acid-soluble oligonucleotides%3B Belongs to the XseA family%3B KEGG: hsw:Hsw_0941 exodeoxyribonuclease VII large subunit gene gene3055 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03056 S101447_03057 S101447_03057 S101447_03057 311585 311821 + hypothetical protein gene gene3056 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03057 S101447_03058 S101447_03058 S101447_03058 311784 312269 - hypothetical protein gene gene3057 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03058 S101447_03059 S101447_03059 S101447_03059 312603 313244 - Insertion element IS407 uncharacterized 31.7 kDa protein Transposable element%3B Contains 1 integrase catalytic domain gene gene3058 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03059 S101447_03060 S101447_03060 S101447_03060 313241 313504 - Low calcium response locus protein Plasmid%3B Belongs to the transposase 8 family gene gene3059 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03060 S101447_03061 S101447_03061 S101447_03061 313861 314103 + Antitoxin RelB DNA-binding%3B Repressor%3B Stress response%3B Transcription%3B Transcription regulation%3B Antitoxin component of a type II toxin-antitoxin (TA) module. Counteracts the effect of cognate toxin RelE via direct protein-protein interaction%2C preventing RelE from entering the ribosome A site and thus inhibiting its endoribonuclease activity. An autorepressor of relBE operon transcription. 2 RelB dimers bind to 2 operator sequence%3B DNA-binding and repression is stronger when complexed with toxin/corepressor RelE by conditional cooperativity (PubMed:18501926%2C PubMed:22981948). Increased transcription rate of relBE and activation of relE is consistent with a lower level of RelB in starved cells due to degradation of RelB by protease Lon%3B Seems to be a principal mediator of cell death in liquid media%3B Belongs to the RelB/DinJ antitoxin family gene gene3060 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03061 S101447_03062 S101447_03062 S101447_03062 314100 314390 + mRNA interferase RelE Antibiotic resistance%3B Endonuclease%3B Hydrolase%3B Nuclease%3B Repressor%3B RNA-binding%3B rRNA-binding%3B Stress response%3B Toxin%3B Transcription%3B Transcription regulation%3B Toxic component of a type II toxin-antitoxin (TA) module (PubMed:9767574). A sequence-specific%2C ribosome-dependent mRNA endoribonuclease that inhibits translation during amino acid starvation (the stringent response). In vitro acts by cleaving mRNA with high codon specificity in the ribosomal A site between positions 2 and 3. The stop codon UAG is cleaved at a fast rate while UAA and UGA are cleaved with intermediate and slow rates. In vitro mRNA cleavage can also occur in the ribosomal E site after peptide release from peptidyl-tRNA in the P site as well as on free 30S subunits (PubMed:12526800). In vivo cuts frequently in the first 100 codons%2C most frequently after the second and third base and rarely near the stop codon (PubMed:21324908). Overexpression of RelE results in the inhibition of bacterial growth and a sharp decrease in colony-forming ability which is neutralized by the labile cognate antitoxin RelB. Overexpression also sharply increases persisters (cells that neither grow nor die in the presence of bactericidal agents and are largely responsible for high levels of biofilm tolerance to antimicrobials) (PubMed:15576765). Plays a role in dormancy when expressed in high-density cells in the absence of antitoxin Rel%3B amino acid starvation and an unidentified extracellular factor promote dormancy%2C while expression of antitoxin RelB restores cell culturability (PubMed:22210768). Acts with RelB as a corepressor of relBE transcription%2C considerably increasing the repression of RelB alone. 2 RelB dimers bind to 2 operator sequence%3B DNA- binding and repression is stronger when complexed with toxin/corepressor RelE by conditional cooperativity (PubMed:9767574%2C PubMed:19747491%2C PubMed:18501926%2C PubMed:22981948)%3B Seems to be a principal mediator of cell death in liquid media (PubMed:19707553). Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847)%3B Cross-talk can occur between different TA modules. Ectopic expression of this toxin induces transcription of 7 tested TA modules (dinJ/yafQ%2C hicAB%2C mazEF%2C mqsRA%2C prlF(sohA)/yhaV%2C relBEF and yefM/yoeB) with specific cleavage of the relBEF mRNA produced immediately upstream and within the relB coding sequence. The cleaved mRNA can be translated into RelE%2C leading to a positive feedback cycle of RelE expression. The relBEF operon is required for transcription of the mazEF TA module operon during amino acid starvation%3B Belongs to the RelE toxin family gene gene3061 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03062 S101447_03063 S101447_03063 S101447_03063 314393 315478 + hypothetical protein gene gene3062 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03063 S101447_03064 S101447_03064 S101447_03064 315491 316534 - putative adenosine monophosphate-protein transferase fic ATP-binding%3B Nucleotide-binding%3B Nucleotidyltransferase%3B Transferase%3B Probable adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (By similarity). Involved in cell filamentation induced by cyclic AMP. May have some role in cell division%3B Belongs to the fic family%3B Contains 1 fido domain gene gene3063 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03064 S101447_03065 S101447_03065 S101447_03065 316534 316890 - hypothetical protein gene gene3064 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03065 S101447_03066 S101447_03066 S101447_03066 317461 318222 - hypothetical protein gene gene3065 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03066 S101447_03067 S101447_03067 S101447_03067 319046 319324 - UPF0335 protein Plasmid%3B Belongs to the UPF0335 family gene gene3066 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03067 S101447_03068 S101447_03068 S101447_03068 320023 321030 + hypothetical protein gene gene3067 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03068 S101447_03069 S101447_03069 S101447_03069 321027 321647 + hypothetical protein gene gene3068 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03069 S101447_03070 S101447_03070 S101447_03070 321687 321995 - hypothetical protein gene gene3069 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03070 S101447_03071 S101447_03071 S101447_03071 322053 322463 - hypothetical protein gene gene3070 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03071 S101447_03072 S101447_03072 S101447_03072 322480 324849 - hypothetical protein gene gene3071 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03072 S101447_03073 S101447_03073 S101447_03073 324863 326239 - hypothetical protein gene gene3072 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03073 S101447_03074 S101447_03074 S101447_03074 326254 327441 - hypothetical protein gene gene3073 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03074 S101447_03075 S101447_03075 S101447_03075 327441 328004 - hypothetical protein gene gene3074 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03075 S101447_03076 S101447_03076 S101447_03076 328001 328384 - hypothetical protein gene gene3075 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03076 S101447_03077 S101447_03077 S101447_03077 328411 328890 - hypothetical protein gene gene3076 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03077 S101447_03078 S101447_03078 S101447_03078 329109 329939 + hypothetical protein gene gene3077 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03078 S101447_03079 S101447_03079 S101447_03079 330500 331387 + hypothetical protein gene gene3078 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03079 S101447_03080 S101447_03080 S101447_03080 331524 332159 + hypothetical protein gene gene3079 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03080 S101447_03081 S101447_03081 S101447_03081 332164 333144 + hypothetical protein gene gene3080 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03081 S101447_03082 S101447_03082 S101447_03082 333144 334379 + hypothetical protein gene gene3081 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03082 S101447_03083 S101447_03083 S101447_03083 334454 335605 + hypothetical protein gene gene3082 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03083 S101447_03084 S101447_03084 S101447_03084 98 538 + hypothetical protein gene gene3083 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03084 S101447_03085 S101447_03085 S101447_03085 613 1785 + hypothetical protein gene gene3084 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03085 S101447_03086 S101447_03086 S101447_03086 1796 2332 + hypothetical protein gene gene3085 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03086 S101447_03087 S101447_03087 S101447_03087 2424 2870 + hypothetical protein gene gene3086 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03087 S101447_03088 S101447_03088 S101447_03088 2882 3508 + hypothetical protein gene gene3087 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03088 S101447_03089 S101447_03089 S101447_03089 3521 6604 + hypothetical protein gene gene3088 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03089 S101447_03090 S101447_03090 S101447_03090 6747 7148 + hypothetical protein gene gene3089 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03090 S101447_03091 S101447_03091 S101447_03091 7597 7863 + Plasmid stability protein StbC Plasmid. gene gene3090 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03091 S101447_03092 S101447_03092 S101447_03092 7860 8054 + Toxin FitB DNA-binding%3B Hydrolase%3B Magnesium%3B Metal-binding%3B Nuclease%3B Toxin%3B Toxic component of a toxin-antitoxin (TA) module. Plays a role in the speed with which bacteria traverse human epithelial cell%3B disruption of the locus increases the speed of trafficking about 2-4-fold. FitAB binds to its own promoter better than FitA alone. The expected nuclease activity was not observed for the FitAB complex%2C perhaps because FitA (the antitoxin) prevents metal binding and thus catalysis by FitB. Belongs to the PINc/VapC protein family%3B Contains 1 PINc domain gene gene3091 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03092 S101447_03093 S101447_03093 S101447_03093 8127 8282 + VapC ribonuclease Hydrolase%3B Magnesium%3B Metal-binding%3B Nuclease%3B Plasmid%3B Toxin%3B Toxic component of a toxin-antitoxin (TA) module. An RNase (By similarity). Involved in plasmid stability (Probable)%3B Belongs to the PINc/VapC protein family%3B Contains 1 PINc domain gene gene3092 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03093 S101447_03094 S101447_03094 S101447_03094 8836 10653 + hypothetical protein gene gene3093 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03094 S101447_03095 S101447_03095 S101447_03095 10646 11653 + hypothetical protein gene gene3094 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03095 S101447_03096 S101447_03096 S101447_03096 11732 12052 + Insertion element ISR1 uncharacterized 10 kDa protein A3 Transposable element%3B Belongs to the transposase 8 family gene gene3095 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03096 S101447_03097 S101447_03097 S101447_03097 11992 12528 + Insertion element IS407 uncharacterized 31.7 kDa protein Transposable element%3B Contains 1 integrase catalytic domain gene gene3096 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03097 S101447_03098 S101447_03098 S101447_03098 13069 13470 - hypothetical protein gene gene3097 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03098 S101447_03099 S101447_03099 S101447_03099 13633 13929 - Putative RelE-like toxin protein Plasmid%3B Toxin%3B Toxic component of a toxin-antitoxin (TA) module%3B Belongs to the RelE toxin family gene gene3098 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03099 S101447_03100 S101447_03100 S101447_03100 13910 14179 - Antitoxin RelB DNA-binding%3B Repressor%3B Stress response%3B Transcription%3B Transcription regulation%3B Antitoxin component of a type II toxin-antitoxin (TA) module. Counteracts the effect of cognate toxin RelE via direct protein-protein interaction%2C preventing RelE from entering the ribosome A site and thus inhibiting its endoribonuclease activity. An autorepressor of relBE operon transcription. 2 RelB dimers bind to 2 operator sequence%3B DNA-binding and repression is stronger when complexed with toxin/corepressor RelE by conditional cooperativity (PubMed:18501926%2C PubMed:22981948). Increased transcription rate of relBE and activation of relE is consistent with a lower level of RelB in starved cells due to degradation of RelB by protease Lon%3B Seems to be a principal mediator of cell death in liquid media%3B Belongs to the RelB/DinJ antitoxin family gene gene3099 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03100 S101447_03101 S101447_03101 S101447_03101 14874 15332 + hypothetical protein gene gene3100 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03101 S101447_03102 S101447_03102 S101447_03102 15325 16359 + hypothetical protein gene gene3101 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03102 S101447_03103 S101447_03103 S101447_03103 16356 17522 + Twitching motility protein ATP-binding%3B Cytoplasm%3B Fimbrium biogenesis%3B Nucleotide-binding%3B Transport%3B May be involved in pilus retraction. Belongs to the GSP E family gene gene3102 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03103 S101447_03104 S101447_03104 S101447_03104 17522 17770 + hypothetical protein gene gene3103 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03104 S101447_03105 S101447_03105 S101447_03105 17767 18201 + hypothetical protein gene gene3104 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03105 S101447_03106 S101447_03106 S101447_03106 18201 18716 + hypothetical protein gene gene3105 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03106 S101447_03107 S101447_03107 S101447_03107 18713 19861 + hypothetical protein gene gene3106 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03107 S101447_03108 S101447_03108 S101447_03108 19874 20506 + hypothetical protein gene gene3107 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03108 S101447_03109 S101447_03109 S101447_03109 20510 22861 + hypothetical protein gene gene3108 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03109 S101447_03110 S101447_03110 S101447_03110 22858 24141 + hypothetical protein gene gene3109 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03110 S101447_03111 S101447_03111 S101447_03111 24289 24432 - hypothetical protein gene gene3110 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03111 S101447_03112 S101447_03112 S101447_03112 24525 27731 - hypothetical protein gene gene3111 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03112 S101447_03113 S101447_03113 S101447_03113 27728 28036 - hypothetical protein gene gene3112 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03113 S101447_03114 S101447_03114 S101447_03114 28080 28295 + hypothetical protein gene gene3113 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03114 S101447_03115 S101447_03115 S101447_03115 28433 28711 - DNA-binding protein HU DNA condensation%3B DNA-binding%3B Virulence%3B Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it%2C and thus to prevent its denaturation under extreme environmental conditions. Seems also to act as a fortuitous virulence factor in delayed sequelae by binding to heparan sulfate-proteoglycans in the extracellular matrix of target organs and acting as a nidus for in situ immune complex formation. Belongs to the bacterial histone-like protein family gene gene3114 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03115 S101447_03116 S101447_03116 S101447_03116 28806 29516 - uncharacterized protein Contains 1 Bro-N domain gene gene3115 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03116 S101447_03117 S101447_03117 S101447_03117 29702 30637 + hypothetical protein gene gene3116 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03117 S101447_03118 S101447_03118 S101447_03118 30754 31602 + hypothetical protein gene gene3117 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03118 S101447_03119 S101447_03119 S101447_03119 31605 32069 + hypothetical protein gene gene3118 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03119 S101447_03120 S101447_03120 S101447_03120 32172 32981 + hypothetical protein gene gene3119 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03120 S101447_03121 S101447_03121 S101447_03121 32994 33398 + hypothetical protein gene gene3120 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03121 S101447_03122 S101447_03122 S101447_03122 33455 33754 - hypothetical protein gene gene3121 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03122 S101447_03123 S101447_03123 S101447_03123 33805 34005 - hypothetical protein gene gene3122 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03123 S101447_03124 S101447_03124 S101447_03124 34241 34651 - Ribonuclease VapC1 Hydrolase%3B Magnesium%3B Metal-binding%3B Nuclease%3B Toxin%3B Toxic component of a toxin-antitoxin (TA) module. Upon expression in E. coli inhibits growth in liquid culture. Its toxic effect is neutralized by coexpression with antitoxin VapB1. Degrades RNA but not ss- or ds-DNA in vitro%2C degradation is inhibited by VapB1 antitoxin%3B Belongs to the PINc/VapC protein family%3B Contains 1 PINc domain%3B KEGG: cnc:CNE_2c21130 tRNA(fMet)-specific endonuclease VapC%3B Acting on ester bonds gene gene3123 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03124 S101447_03125 S101447_03125 S101447_03125 34648 34920 - hypothetical protein gene gene3124 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03125 S101447_03126 S101447_03126 S101447_03126 34993 35409 - hypothetical protein gene gene3125 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03126 S101447_03127 S101447_03127 S101447_03127 35406 35840 - hypothetical protein gene gene3126 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03127 S101447_03128 S101447_03128 S101447_03128 35904 36401 - Single-stranded DNA-binding protein DNA damage%3B DNA recombination%3B DNA repair%3B DNA replication%3B DNA-binding%3B Plays an important role in DNA replication%2C recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism%3B Contains 1 SSB domain gene gene3127 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03128 S101447_03129 S101447_03129 S101447_03129 37162 37308 - hypothetical protein gene gene3128 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03129 S101447_03130 S101447_03130 S101447_03130 37658 38338 - hypothetical protein gene gene3129 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03130 S101447_03131 S101447_03131 S101447_03131 38893 39243 + hypothetical protein gene gene3130 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03131 S101447_03132 S101447_03132 S101447_03132 39286 39408 - hypothetical protein gene gene3131 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03132 S101447_03133 S101447_03133 S101447_03133 39405 39623 - hypothetical protein gene gene3132 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03133 S101447_03134 S101447_03134 S101447_03134 39754 40170 - hypothetical protein gene gene3133 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03134 S101447_03135 S101447_03135 S101447_03135 40160 40405 - hypothetical protein gene gene3134 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03135 S101447_03136 S101447_03136 S101447_03136 40906 41319 + hypothetical protein gene gene3135 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03136 S101447_03137 S101447_03137 S101447_03137 41265 42074 + Putative MucR family transcriptional regulatory protein DNA-binding%3B Plasmid%3B Transcription%3B Transcription regulation%3B Belongs to the ros/MucR family gene gene3136 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03137 S101447_03138 S101447_03138 S101447_03138 42167 42358 + hypothetical protein gene gene3137 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03138 S101447_03139 S101447_03139 S101447_03139 42383 42637 + hypothetical protein gene gene3138 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03139 S101447_03140 S101447_03140 S101447_03140 43085 43315 + hypothetical protein gene gene3139 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03140 S101447_03141 S101447_03141 S101447_03141 132 524 - hypothetical protein gene gene3140 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03141 S101447_03142 S101447_03142 S101447_03142 521 631 - hypothetical protein gene gene3141 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03142 S101447_03143 S101447_03143 S101447_03143 684 782 - hypothetical protein gene gene3142 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03143 S101447_03144 S101447_03144 S101447_03144 991 1122 + hypothetical protein gene gene3143 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03144 S101447_03145 S101447_03145 S101447_03145 1180 1746 + hypothetical protein gene gene3144 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03145 S101447_03146 S101447_03146 S101447_03146 2278 2490 - hypothetical protein gene gene3145 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03146 S101447_03147 S101447_03147 S101447_03147 2782 3075 + Alcohol dehydrogenase Cytoplasm%3B NADP%3B Oxidoreductase%3B Catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA. Is essential for growth with 3-hydroxypropanoate as a sole carbon source. Restores acrylate resistance when expressed in the E. coli strain K12 acuI deletion%3B Belongs to the zinc-containing alcohol dehydrogenase family. Acrylyl-CoA reductase subfamily%3B KEGG: cgl:NCgl2449 alcohol dehydrogenase gene gene3146 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03147 S101447_03148 S101447_03148 S101447_03148 3107 3412 - putative HTH-type transcriptional regulator YbzH DNA-binding%3B Transcription%3B Transcription regulation%3B Contains 1 HTH arsR-type DNA-binding domain gene gene3147 http://www.ncbi.nlm.nih.gov/gene/?term=S101447_03148