locus-tag	class	description
S1001342_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S1001342_00002	COG0592	DNA-directed DNA polymerase activity
S1001342_00003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S1001342_00004	COG0187	DNA topoisomerase II activity
S1001342_00005	COG2877	3-deoxy-8-phosphooctulonate synthase activity
S1001342_00006	COG0504	CTP synthase activity
S1001342_00008	COG0149	triose-phosphate isomerase activity
S1001342_00010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S1001342_00012	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S1001342_00013	COG0134	indole-3-glycerol-phosphate synthase activity
S1001342_00014	COG0315	cyclic pyranopterin monophosphate synthase activity
S1001342_00015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S1001342_00016	COG0508	dehydrogenase complex catalyzes the overall conversion of
S1001342_00016	COG0022	dehydrogenase e1 component
S1001342_00017	COG0508	dehydrogenase complex catalyzes the overall conversion of
S1001342_00018	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S1001342_00019	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
S1001342_00022	COG1546	Belongs to the CinA family
S1001342_00025	COG0861	Integral membrane protein TerC family
S1001342_00026	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S1001342_00027	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S1001342_00028	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S1001342_00030	COG0047	phosphoribosylformylglycinamidine synthase activity
S1001342_00031	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S1001342_00032	COG0271	Belongs to the BolA IbaG family
S1001342_00033	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
S1001342_00035	COG0792	nuclease activity
S1001342_00038	COG0628	permease
S1001342_00039	COG2897	thiosulfate sulfurtransferase activity
S1001342_00040	COG0626	cystathionine gamma-synthase activity
S1001342_00041	COG0606	chelatase, subunit chli
S1001342_00045	COG0606	chelatase, subunit chli
S1001342_00046	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S1001342_00048	COG3474	cytochrome
S1001342_00049	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
S1001342_00050	COG0077	Prephenate dehydratase
S1001342_00050	COG1605	Chorismate mutase
S1001342_00051	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S1001342_00052	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S1001342_00053	COG1278	Cold shock
S1001342_00059	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S1001342_00062	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S1001342_00063	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S1001342_00064	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S1001342_00068	COG1663	tetraacyldisaccharide 4'-kinase activity
S1001342_00069	COG1519	Transferase
S1001342_00071	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S1001342_00074	COG0175	sulfate reduction
S1001342_00075	COG0175	sulfate reduction
S1001342_00077	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S1001342_00078	COG0602	queuosine metabolic process
S1001342_00079	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S1001342_00081	COG0579	oxidoreductase
S1001342_00082	COG1764	response to oxidative stress
S1001342_00083	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S1001342_00084	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S1001342_00085	COG0259	pyridoxamine-phosphate oxidase activity
S1001342_00087	COG1234	tRNA 3'-trailer cleavage
S1001342_00088	COG0084	hydrolase, TatD family'
S1001342_00091	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S1001342_00092	COG1686	Belongs to the peptidase S11 family
S1001342_00094	COG2951	lytic endotransglycosylase activity
S1001342_00095	COG0586	Pfam SNARE associated Golgi protein
S1001342_00097	COG0531	amino acid
S1001342_00098	COG1968	undecaprenyl-diphosphatase activity
S1001342_00102	COG2890	protein-(glutamine-N5) methyltransferase activity
S1001342_00104	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S1001342_00105	COG0124	histidyl-tRNA synthetase
S1001342_00106	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S1001342_00108	COG2070	2-Nitropropane dioxygenase
S1001342_00109	COG0527	aspartate kinase activity
S1001342_00110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S1001342_00111	COG2706	6-phosphogluconolactonase activity
S1001342_00116	COG2226	methyltransferase
S1001342_00117	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S1001342_00121	COG0321	lipoyl(octanoyl) transferase activity
S1001342_00123	COG0271	Belongs to the BolA IbaG family
S1001342_00124	COG0484	heat shock protein binding
S1001342_00127	COG0076	glutamate decarboxylase activity
S1001342_00130	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S1001342_00131	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
S1001342_00134	COG2022	thiamine diphosphate biosynthetic process
S1001342_00138	COG0148	phosphopyruvate hydratase activity
S1001342_00140	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S1001342_00141	COG0303	'Molybdopterin
S1001342_00142	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S1001342_00143	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
S1001342_00143	COG4106	trans-aconitate 2-methyltransferase activity
S1001342_00145	COG0156	8-amino-7-oxononanoate synthase activity
S1001342_00146	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S1001342_00147	COG0314	molybdopterin synthase activity
S1001342_00148	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
S1001342_00151	COG0322	excinuclease ABC activity
S1001342_00155	COG0729	surface antigen
S1001342_00157	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S1001342_00159	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S1001342_00161	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S1001342_00166	COG0287	Prephenate dehydrogenase
S1001342_00166	COG1605	Chorismate mutase
S1001342_00167	COG2062	phosphohistidine phosphatase, SixA
S1001342_00170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S1001342_00171	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S1001342_00172	COG0142	geranyltranstransferase activity
S1001342_00174	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S1001342_00175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S1001342_00175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S1001342_00177	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S1001342_00178	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S1001342_00180	COG1970	mechanosensitive ion channel activity
S1001342_00181	COG0254	rRNA binding
S1001342_00182	COG0071	Belongs to the small heat shock protein (HSP20) family
S1001342_00186	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S1001342_00187	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S1001342_00188	COG2003	Belongs to the UPF0758 family
S1001342_00189	COG2003	Belongs to the UPF0758 family
S1001342_00191	COG2264	protein methyltransferase activity
S1001342_00192	COG0006	proline dipeptidase activity
S1001342_00193	COG0473	3-isopropylmalate dehydrogenase activity
S1001342_00196	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S1001342_00200	COG0747	negative chemotaxis
S1001342_00202	COG0072	phenylalanine-tRNA ligase activity
S1001342_00202	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S1001342_00203	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S1001342_00204	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S1001342_00205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S1001342_00206	COG0246	Mannitol dehydrogenase
S1001342_00207	COG2010	Cytochrome c
S1001342_00207	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S1001342_00211	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S1001342_00212	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S1001342_00217	COG2884	Cell division ATP-binding protein ftsE
S1001342_00220	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
S1001342_00221	COG3781	membrane
S1001342_00222	COG1329	Transcriptional regulator
S1001342_00223	COG0859	PFAM glycosyl transferase family 9
S1001342_00223	COG0457	Tetratricopeptide repeat
S1001342_00225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S1001342_00226	COG2081	HI0933 family
S1001342_00228	COG0850	regulation of cytokinetic process
S1001342_00230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
S1001342_00231	COG1802	Transcriptional regulator
S1001342_00232	COG1132	(ABC) transporter
S1001342_00236	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
S1001342_00238	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S1001342_00239	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
S1001342_00240	COG0359	binds to the 23S rRNA
S1001342_00241	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S1001342_00242	COG0360	Binds together with S18 to 16S ribosomal RNA
S1001342_00244	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S1001342_00245	COG0358	DNA primase activity
S1001342_00247	COG0505	Belongs to the CarA family
S1001342_00248	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S1001342_00249	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S1001342_00250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S1001342_00251	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
S1001342_00253	COG0793	Belongs to the peptidase S41A family
S1001342_00255	COG1051	belongs to the nudix hydrolase family
S1001342_00256	COG2814	Major facilitator Superfamily
S1001342_00258	COG1132	(ABC) transporter
S1001342_00259	COG0617	tRNA 3'-terminal CCA addition
S1001342_00261	COG0714	Associated with various cellular activities
S1001342_00266	COG2189	Belongs to the N(4) N(6)-methyltransferase family
S1001342_00267	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S1001342_00268	COG3237	CsbD-like
S1001342_00269	COG0477	Major facilitator Superfamily
S1001342_00270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S1001342_00271	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S1001342_00273	COG1538	Outer membrane efflux protein
S1001342_00274	COG5487	UPF0391 membrane protein
S1001342_00276	COG1116	anion transmembrane transporter activity
S1001342_00277	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S1001342_00279	COG0203	ribosomal protein L17
S1001342_00280	COG0202	RNA polymerase activity
S1001342_00281	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S1001342_00282	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S1001342_00283	COG0563	adenylate kinase activity
S1001342_00285	COG0200	Binds to the 23S rRNA
S1001342_00286	COG1841	ribosomal large subunit assembly
S1001342_00287	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S1001342_00288	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S1001342_00289	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S1001342_00290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S1001342_00291	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S1001342_00292	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S1001342_00293	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S1001342_00294	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S1001342_00295	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S1001342_00296	COG0255	Belongs to the universal ribosomal protein uL29 family
S1001342_00297	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S1001342_00298	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S1001342_00299	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S1001342_00300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S1001342_00301	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S1001342_00302	COG0089	rRNA binding
S1001342_00303	COG0088	Forms part of the polypeptide exit tunnel
S1001342_00304	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S1001342_00305	COG0051	transcription antitermination factor activity, RNA binding
S1001342_00306	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S1001342_00307	COG0049	tRNA binding
S1001342_00308	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S1001342_00309	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S1001342_00310	COG0085	RNA polymerase activity
S1001342_00311	COG0222	ribosome binding
S1001342_00312	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S1001342_00313	COG0081	regulation of translation
S1001342_00314	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S1001342_00321	COG0477	Major facilitator Superfamily
S1001342_00323	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S1001342_00329	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
S1001342_00337	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S1001342_00339	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
S1001342_00340	COG1138	Cytochrome C-type biogenesis protein
S1001342_00341	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S1001342_00342	COG3088	subunit of a heme lyase
S1001342_00346	COG1289	transmembrane transporter activity
S1001342_00347	COG1289	transmembrane transporter activity
S1001342_00352	COG1121	(ABC) transporter
S1001342_00355	COG0248	Ppx GppA phosphatase
S1001342_00356	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
S1001342_00358	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S1001342_00359	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S1001342_00361	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S1001342_00365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S1001342_00366	COG0237	dephospho-CoA kinase activity
S1001342_00367	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S1001342_00370	COG0165	Argininosuccinate lyase
S1001342_00371	COG0019	diaminopimelate decarboxylase activity
S1001342_00373	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S1001342_00374	COG3591	Belongs to the peptidase S1B family
S1001342_00376	COG0640	Transcriptional regulator
S1001342_00377	COG1902	pentaerythritol trinitrate reductase activity
S1001342_00378	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S1001342_00383	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S1001342_00390	COG0778	Nitroreductase
S1001342_00393	COG3293	Transposase
S1001342_00395	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S1001342_00396	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S1001342_00396	COG2857	Cytochrome c1
S1001342_00397	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S1001342_00397	COG2857	Cytochrome c1
S1001342_00398	COG0408	coproporphyrinogen oxidase activity
S1001342_00402	COG2189	Belongs to the N(4) N(6)-methyltransferase family
S1001342_00404	COG0406	alpha-ribazole phosphatase activity
S1001342_00405	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
S1001342_00407	COG0181	hydroxymethylbilane synthase activity
S1001342_00408	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S1001342_00409	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
S1001342_00412	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
S1001342_00413	COG1546	Belongs to the CinA family
S1001342_00413	COG1058	Belongs to the CinA family
S1001342_00414	COG0825	malonyl-CoA metabolic process
S1001342_00415	COG4974	Belongs to the 'phage' integrase family
S1001342_00417	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S1001342_00418	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
S1001342_00418	COG2885	chlorophyll binding
S1001342_00420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S1001342_00421	COG0688	phosphatidylethanolamine metabolic process
S1001342_00422	COG1183	phosphatidylcholine synthase activity
S1001342_00423	COG3260	NADH ubiquinone oxidoreductase 20
S1001342_00430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S1001342_00433	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
S1001342_00437	COG0508	dehydrogenase complex catalyzes the overall conversion of
S1001342_00439	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
S1001342_00440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S1001342_00441	COG0658	competence protein
S1001342_00441	COG2333	competence protein COMEC
S1001342_00442	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S1001342_00443	COG0540	Belongs to the ATCase OTCase family
S1001342_00444	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S1001342_00445	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S1001342_00446	COG0758	DNA mediated transformation
S1001342_00447	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S1001342_00448	COG0557	exoribonuclease II activity
S1001342_00449	COG0793	Belongs to the peptidase S41A family
S1001342_00451	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
S1001342_00451	COG2885	chlorophyll binding
S1001342_00452	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S1001342_00453	COG1959	2 iron, 2 sulfur cluster binding
S1001342_00456	COG0187	DNA topoisomerase II activity
S1001342_00457	COG5006	permease, DMT superfamily
S1001342_00459	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S1001342_00461	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S1001342_00462	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S1001342_00463	COG0196	riboflavin kinase activity
S1001342_00464	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
S1001342_00465	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
S1001342_00466	COG0235	Class ii aldolase
S1001342_00467	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S1001342_00470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S1001342_00471	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S1001342_00473	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S1001342_00475	COG1643	Atp-dependent helicase
S1001342_00477	COG0656	L-ascorbic acid biosynthetic process
S1001342_00479	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S1001342_00481	COG0009	L-threonylcarbamoyladenylate synthase
S1001342_00486	COG2096	Adenosyltransferase
S1001342_00492	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S1001342_00495	COG0506	proline dehydrogenase activity
S1001342_00495	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
S1001342_00495	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
S1001342_00497	COG1113	amino acid transport
S1001342_00505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
S1001342_00506	COG1127	ABC transporter
S1001342_00508	COG3264	Mechanosensitive ion channel
S1001342_00508	COG1196	nuclear chromosome segregation
S1001342_00510	COG0305	Participates in initiation and elongation during chromosome replication
S1001342_00511	COG2942	2-epimerase
S1001342_00512	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S1001342_00512	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
S1001342_00513	COG0194	GDP metabolic process
S1001342_00516	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S1001342_00518	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
S1001342_00518	COG0517	IMP dehydrogenase activity
S1001342_00521	COG1137	ATPase activity
S1001342_00522	COG0633	Ferredoxin
S1001342_00522	COG3217	Mosc domain protein beta barrel domain protein
S1001342_00524	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S1001342_00527	COG0242	peptide deformylase activity
S1001342_00528	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S1001342_00529	COG0101	tRNA pseudouridine synthase activity
S1001342_00531	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S1001342_00532	COG2171	N-acyltransferase activity
S1001342_00533	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S1001342_00534	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S1001342_00535	COG0706	membrane insertase activity
S1001342_00536	COG0594	ribonuclease P activity
S1001342_00537	COG0230	Belongs to the bacterial ribosomal protein bL34 family
S1001342_00539	COG0346	lactoylglutathione lyase activity
S1001342_00540	COG3494	Protein of unknown function (DUF1009)
S1001342_00541	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S1001342_00542	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S1001342_00543	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S1001342_00546	COG0750	zinc metalloprotease
S1001342_00547	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S1001342_00549	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S1001342_00550	COG0233	cytoplasmic translational termination
S1001342_00551	COG0528	UMP kinase activity
S1001342_00552	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S1001342_00553	COG0571	ribonuclease III activity
S1001342_00554	COG0681	Belongs to the peptidase S26 family
S1001342_00555	COG0736	holo-[acyl-carrier-protein] synthase activity
S1001342_00556	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S1001342_00557	COG1758	RNA polymerase activity
S1001342_00563	COG0513	Belongs to the DEAD box helicase family
S1001342_00564	COG2813	Specifically methylates the guanine in position
S1001342_00564	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S1001342_00565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S1001342_00566	COG0481	GTPase activity
S1001342_00569	COG4993	Dehydrogenase
S1001342_00577	COG0538	isocitrate dehydrogenase activity
S1001342_00578	COG0492	ferredoxin-NADP+ reductase activity
S1001342_00579	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S1001342_00585	COG0469	pyruvate kinase activity
S1001342_00587	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S1001342_00592	COG1297	OPT oligopeptide transporter protein
S1001342_00595	COG0596	Alpha beta hydrolase
S1001342_00596	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
S1001342_00598	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S1001342_00600	COG0523	cobalamin synthesis protein
S1001342_00602	COG1252	NADH dehydrogenase
S1001342_00604	COG0071	Belongs to the small heat shock protein (HSP20) family
S1001342_00606	COG0022	dehydrogenase e1 component
S1001342_00607	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S1001342_00609	COG0306	phosphate transporter
S1001342_00617	COG1607	acyl-coa hydrolase
S1001342_00620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S1001342_00621	COG4221	oxidoreductase activity
S1001342_00622	COG1959	2 iron, 2 sulfur cluster binding
S1001342_00662	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S1001342_00662	COG2755	lipolytic protein G-D-S-L family
S1001342_00686	COG4774	siderophore transport
S1001342_00709	COG1396	sequence-specific DNA binding
S1001342_00709	COG3800	Transcriptional regulator
S1001342_00711	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S1001342_00722	COG1802	Transcriptional regulator
S1001342_00722	COG4626	Terminase
S1001342_00756	COG1012	belongs to the aldehyde dehydrogenase family
S1001342_00771	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S1001342_00776	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S1001342_00777	COG0415	Belongs to the DNA photolyase family
S1001342_00781	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S1001342_00782	COG2971	BadF BadG BcrA BcrD
S1001342_00783	COG3525	Glycosyl hydrolase, family 20, catalytic domain
S1001342_00784	COG1120	ATPase activity
S1001342_00785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S1001342_00787	COG4771	TonB-dependent receptor
S1001342_00789	COG0025	NhaP-type Na H and K H
S1001342_00793	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S1001342_00797	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S1001342_00797	COG0519	Catalyzes the synthesis of GMP from XMP
S1001342_00800	COG2814	Major facilitator Superfamily
S1001342_00801	COG1196	nuclear chromosome segregation
S1001342_00801	COG0739	heme binding
S1001342_00801	COG0741	lytic transglycosylase activity
S1001342_00805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S1001342_00812	COG1742	UPF0060 membrane protein
S1001342_00815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S1001342_00818	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S1001342_00819	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S1001342_00821	COG0363	glucosamine-6-phosphate deaminase activity
S1001342_00822	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
S1001342_00823	COG3265	gluconokinase activity
S1001342_00830	COG3158	transport of potassium into the cell
S1001342_00831	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S1001342_00848	COG2963	transposase activity
S1001342_00849	COG2963	transposase activity
S1001342_00853	COG2963	transposase activity
S1001342_00855	COG3547	Transposase (IS116 IS110 IS902 family)
S1001342_00860	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
S1001342_00860	COG0662	Cupin 2, conserved barrel domain protein
S1001342_00863	COG0438	transferase activity, transferring glycosyl groups
S1001342_00865	COG2963	transposase activity
S1001342_00867	COG4372	Transposase
S1001342_00869	COG3961	Belongs to the TPP enzyme family
S1001342_00874	COG1393	Belongs to the ArsC family
S1001342_00876	COG2818	Glycosylase
S1001342_00877	COG0640	Transcriptional regulator
S1001342_00878	COG0450	alkyl hydroperoxide reductase
S1001342_00887	COG0583	DNA-binding transcription factor activity
S1001342_00897	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S1001342_00899	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
S1001342_00903	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S1001342_00903	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S1001342_00904	COG0509	glycine decarboxylation via glycine cleavage system
S1001342_00905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S1001342_00906	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S1001342_00907	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S1001342_00909	COG0583	DNA-binding transcription factor activity
S1001342_00911	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S1001342_00912	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S1001342_00913	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S1001342_00916	COG1185	polyribonucleotide nucleotidyltransferase activity
S1001342_00918	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S1001342_00919	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S1001342_00920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
S1001342_00921	COG1127	ABC transporter
S1001342_00922	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
S1001342_00922	COG3008	intermembrane lipid transfer
S1001342_00932	COG1410	methionine synthase
S1001342_00932	COG0646	methionine synthase
S1001342_00935	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S1001342_00937	COG3008	intermembrane lipid transfer
S1001342_00938	COG2995	paraquat-inducible protein a
S1001342_00940	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S1001342_00941	COG0463	Glycosyl transferase, family 2
S1001342_00942	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S1001342_00943	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S1001342_00944	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S1001342_00945	COG0356	it plays a direct role in the translocation of protons across the membrane
S1001342_00948	COG0552	protein localization to endoplasmic reticulum
S1001342_00949	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S1001342_00950	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S1001342_00951	COG0346	lactoylglutathione lyase activity
S1001342_00953	COG0513	Belongs to the DEAD box helicase family
S1001342_00956	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S1001342_00957	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S1001342_00960	COG0704	Plays a role in the regulation of phosphate uptake
S1001342_00961	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S1001342_00963	COG0573	inorganic phosphate transmembrane transporter activity
S1001342_00964	COG0129	dihydroxy-acid dehydratase activity
S1001342_00972	COG0489	protein tyrosine kinase activity
S1001342_00975	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
S1001342_00977	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
S1001342_00977	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
S1001342_00981	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S1001342_00982	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S1001342_00983	COG1522	sequence-specific DNA binding
S1001342_00984	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S1001342_00985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S1001342_00988	COG0779	Required for maturation of 30S ribosomal subunits
S1001342_00990	COG0542	response to heat
S1001342_00993	COG0765	amino acid transport
S1001342_00994	COG1126	abc transporter atp-binding protein
S1001342_00997	COG4133	protoheme IX ABC transporter activity
S1001342_01001	COG1295	ribonuclease BN
S1001342_01003	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S1001342_01004	COG0511	ligase activity, forming carbon-carbon bonds
S1001342_01005	COG0439	Biotin carboxylase
S1001342_01006	COG2814	Major facilitator Superfamily
S1001342_01007	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S1001342_01016	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S1001342_01019	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S1001342_01020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S1001342_01021	COG0154	amidase activity
S1001342_01022	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S1001342_01041	COG3293	Transposase
S1001342_01048	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S1001342_01059	COG5265	(ABC) transporter
S1001342_01060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S1001342_01061	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S1001342_01067	COG0495	leucyl-tRNA aminoacylation
S1001342_01083	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S1001342_01085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S1001342_01086	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S1001342_01087	COG0590	tRNA wobble adenosine to inosine editing
S1001342_01089	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
S1001342_01090	COG1187	pseudouridine synthase activity
S1001342_01091	COG0742	ribosomal rna small subunit methyltransferase
S1001342_01092	COG0629	single-stranded DNA binding
S1001342_01094	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S1001342_01099	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S1001342_01101	COG4372	Transposase
S1001342_01103	COG2963	transposase activity
S1001342_01105	COG0438	transferase activity, transferring glycosyl groups
S1001342_01107	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S1001342_01108	COG0312	modulator of DNA gyrase
S1001342_01109	COG0406	alpha-ribazole phosphatase activity
S1001342_01113	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
S1001342_01114	COG1091	dTDP-4-dehydrorhamnose reductase activity
S1001342_01116	COG1674	ftsk spoiiie
S1001342_01117	COG0564	pseudouridine synthase activity
S1001342_01120	COG0482	sulfurtransferase activity
S1001342_01122	COG1104	cysteine desulfurase activity
S1001342_01124	COG2945	thiolester hydrolase activity
S1001342_01126	COG0215	cysteine-tRNA ligase activity
S1001342_01128	COG0285	dihydrofolate synthase activity
S1001342_01129	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S1001342_01132	COG2887	Belongs to the helicase family. UvrD subfamily
S1001342_01133	COG0802	atpase or kinase
S1001342_01134	COG0745	RESPONSE REGULATOR receiver
S1001342_01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S1001342_01137	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S1001342_01138	COG0037	tRNA processing
S1001342_01140	COG2885	chlorophyll binding
S1001342_01141	COG0823	Involved in the tonB-independent uptake of proteins
S1001342_01143	COG0848	biopolymer transport protein
S1001342_01145	COG0824	Thioesterase
S1001342_01146	COG2255	four-way junction helicase activity
S1001342_01147	COG0632	four-way junction helicase activity
S1001342_01148	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
S1001342_01149	COG0217	transcriptional regulatory protein
S1001342_01150	COG0653	protein targeting
S1001342_01151	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S1001342_01152	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S1001342_01154	COG0668	transmembrane transport
S1001342_01166	COG0776	regulation of translation
S1001342_01170	COG0463	Glycosyl transferase, family 2
S1001342_01170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S1001342_01173	COG0131	Imidazoleglycerol-phosphate dehydratase
S1001342_01174	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S1001342_01175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S1001342_01176	COG0107	imidazoleglycerol-phosphate synthase activity
S1001342_01177	COG0140	phosphoribosyl-ATP diphosphatase activity
S1001342_01179	COG0778	Nitroreductase
S1001342_01188	COG1475	DNA binding
S1001342_01189	COG1192	Involved in chromosome partitioning
S1001342_01190	COG0357	Ribosomal RNA small subunit methyltransferase G
S1001342_01191	COG0445	tRNA wobble uridine modification
S1001342_01192	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S1001342_01193	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S1001342_01197	COG1611	Belongs to the LOG family
S1001342_01198	COG2814	Major facilitator Superfamily
S1001342_01201	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S1001342_01202	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S1001342_01205	COG1671	Belongs to the UPF0178 family
S1001342_01207	COG2814	Major facilitator Superfamily
S1001342_01209	COG2835	tetraacyldisaccharide 4'-kinase activity
S1001342_01210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S1001342_01219	COG0778	Nitroreductase
S1001342_01221	COG0456	acetyltransferase
S1001342_01223	COG1570	exodeoxyribonuclease VII activity
S1001342_01226	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S1001342_01232	COG1012	belongs to the aldehyde dehydrogenase family
S1001342_01234	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
S1001342_01235	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
S1001342_01236	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
S1001342_01237	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S1001342_01239	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
S1001342_01241	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S1001342_01244	COG0126	phosphoglycerate kinase activity
S1001342_01246	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S1001342_01248	COG0156	8-amino-7-oxononanoate synthase activity
S1001342_01249	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S1001342_01250	COG0405	Gamma-glutamyltransferase
S1001342_01254	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
S1001342_01256	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S1001342_01260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S1001342_01261	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S1001342_01263	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S1001342_01265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S1001342_01266	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S1001342_01267	COG0539	negative regulation of cytoplasmic translation
S1001342_01269	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S1001342_01270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S1001342_01271	COG1420	regulation of RNA biosynthetic process
S1001342_01272	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
S1001342_01279	COG0772	Belongs to the SEDS family
S1001342_01280	COG0768	penicillin binding
S1001342_01284	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S1001342_01285	COG1612	heme a metabolic process
S1001342_01287	COG2814	Major facilitator Superfamily
S1001342_01289	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S1001342_01290	COG1289	transmembrane transporter activity
S1001342_01292	COG1573	uracil-dna glycosylase
S1001342_01296	COG0670	Belongs to the BI1 family
S1001342_01300	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S1001342_01303	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S1001342_01306	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S1001342_01310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S1001342_01314	COG1028	Short-chain dehydrogenase reductase Sdr
S1001342_01315	COG0586	Pfam SNARE associated Golgi protein
S1001342_01317	COG0281	malic enzyme
S1001342_01322	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S1001342_01323	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S1001342_01324	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S1001342_01325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S1001342_01326	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S1001342_01327	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S1001342_01328	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
S1001342_01329	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S1001342_01332	COG1113	amino acid transport
S1001342_01333	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
S1001342_01334	COG4208	sulfate ABC transporter
S1001342_01339	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
S1001342_01340	COG2207	Transcriptional regulator
S1001342_01341	COG4303	Ethanolamine ammonia lyase large subunit
S1001342_01342	COG4302	ethanolamine ammonia-lyase activity
S1001342_01344	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S1001342_01346	COG1538	Outer membrane efflux protein
S1001342_01347	COG1278	Cold shock
S1001342_01359	COG2983	Belongs to the UPF0260 family
S1001342_01362	COG3842	ATPase activity
S1001342_01366	COG1566	PFAM secretion protein HlyD family protein
S1001342_01370	COG1657	PFAM Prenyltransferase squalene oxidase
S1001342_01371	COG1233	COG1233 Phytoene dehydrogenase and related
S1001342_01372	COG1562	ergosterol biosynthetic process
S1001342_01373	COG1562	ergosterol biosynthetic process
S1001342_01375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S1001342_01377	COG0287	Prephenate dehydrogenase
S1001342_01379	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S1001342_01381	COG0450	alkyl hydroperoxide reductase
S1001342_01382	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S1001342_01386	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
S1001342_01388	COG0488	(ABC) transporter
S1001342_01392	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
S1001342_01394	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S1001342_01395	COG0343	queuine tRNA-ribosyltransferase activity
S1001342_01396	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S1001342_01398	COG1881	PFAM PEBP family protein
S1001342_01401	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S1001342_01404	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S1001342_01410	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
S1001342_01411	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S1001342_01414	COG0667	Aldo Keto reductase
S1001342_01416	COG0556	nucleotide-excision repair
S1001342_01418	COG0612	Peptidase, M16
S1001342_01431	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S1001342_01434	COG0167	dihydroorotate dehydrogenase activity
S1001342_01436	COG1051	belongs to the nudix hydrolase family
S1001342_01437	COG1692	metallophosphoesterase
S1001342_01438	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S1001342_01443	COG0352	thiamine-phosphate diphosphorylase activity
S1001342_01448	COG1509	lysine 2,3-aminomutase activity
S1001342_01450	COG0024	Methionine aminopeptidase
S1001342_01451	COG1686	Belongs to the peptidase S11 family
S1001342_01452	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
S1001342_01455	COG2326	polyphosphate kinase activity
S1001342_01456	COG1678	Uncharacterized ACR, COG1678
S1001342_01457	COG1660	Displays ATPase and GTPase activities
S1001342_01459	COG2205	protein histidine kinase activity
S1001342_01460	COG0745	RESPONSE REGULATOR receiver
S1001342_01461	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S1001342_01462	COG0443	Heat shock 70 kDa protein
S1001342_01463	COG0484	heat shock protein binding
S1001342_01464	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S1001342_01465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S1001342_01466	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S1001342_01467	COG0138	bifunctional purine biosynthesis protein purh
S1001342_01470	COG0697	spore germination
S1001342_01472	COG0752	glycyl-tRNA synthetase alpha subunit
S1001342_01474	COG1396	sequence-specific DNA binding
S1001342_01475	COG0815	Transfers the fatty acyl group on membrane lipoproteins
S1001342_01479	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S1001342_01481	COG0598	Magnesium transport protein CorA
S1001342_01482	COG0133	tryptophan synthase activity
S1001342_01483	COG0159	tryptophan synthase activity
S1001342_01484	COG1053	succinate dehydrogenase
S1001342_01484	COG3976	FMN-binding domain protein
S1001342_01484	COG0431	NADPH-dependent FMN reductase
S1001342_01486	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S1001342_01487	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S1001342_01488	COG0745	RESPONSE REGULATOR receiver
S1001342_01490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S1001342_01495	COG1253	flavin adenine dinucleotide binding
S1001342_01496	COG0604	alcohol dehydrogenase
S1001342_01498	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S1001342_01501	COG1028	Short-chain dehydrogenase reductase Sdr
S1001342_01502	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S1001342_01503	COG3956	TIGRFAM MazG family protein
S1001342_01505	COG0326	Molecular chaperone. Has ATPase activity
S1001342_01571	COG2079	MmgE PrpD family protein
S1001342_01572	COG0372	Belongs to the citrate synthase family
S1001342_01573	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S1001342_01574	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S1001342_01575	COG2814	Major facilitator Superfamily
S1001342_01576	COG2814	Major facilitator Superfamily
S1001342_01578	COG2319	Wd-40 repeat
S1001342_01580	COG2309	aminopeptidase activity
S1001342_01583	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S1001342_01585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S1001342_01586	COG0193	aminoacyl-tRNA hydrolase activity
S1001342_01587	COG0012	GTP binding
S1001342_01588	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S1001342_01589	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S1001342_01590	COG0799	negative regulation of ribosome biogenesis
S1001342_01591	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S1001342_01598	COG0247	lactate metabolic process
S1001342_01599	COG1139	Iron-sulfur cluster binding protein
S1001342_01601	COG0697	spore germination
S1001342_01602	COG0697	spore germination
S1001342_01603	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S1001342_01604	COG0717	Belongs to the dCTP deaminase family
S1001342_01607	COG3394	polysaccharide catabolic process
S1001342_01611	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S1001342_01612	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S1001342_01613	COG1253	flavin adenine dinucleotide binding
S1001342_01614	COG0741	lytic transglycosylase activity
S1001342_01616	COG1573	uracil-dna glycosylase
S1001342_01618	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S1001342_01627	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S1001342_01635	COG1028	Short-chain dehydrogenase reductase Sdr
S1001342_01637	COG0025	NhaP-type Na H and K H
S1001342_01639	COG0735	belongs to the Fur family
S1001342_01641	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
S1001342_01642	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S1001342_01644	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S1001342_01645	COG1024	Enoyl-CoA hydratase
S1001342_01646	COG1584	GPR1 FUN34 yaaH family protein
S1001342_01647	COG1289	transmembrane transporter activity
S1001342_01652	COG1797	cobyrinic acid a,c-diamide synthase activity
S1001342_01655	COG1492	cobalamin metabolic process
S1001342_01656	COG0778	Nitroreductase
S1001342_01657	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
S1001342_01659	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
S1001342_01660	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
S1001342_01662	COG2814	Major facilitator Superfamily
S1001342_01670	COG1301	dicarboxylic acid transport
S1001342_01674	COG0848	biopolymer transport protein
S1001342_01676	COG4774	siderophore transport
S1001342_01679	COG3128	pkhd-type hydroxylase
S1001342_01684	COG2814	Major facilitator Superfamily
S1001342_01688	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S1001342_01690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S1001342_01690	COG1648	precorrin-2 dehydrogenase activity
S1001342_01691	COG0277	FAD linked oxidase domain protein
S1001342_01693	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S1001342_01694	COG2011	ABC-type metal ion transport system permease component
S1001342_01696	COG3620	sequence-specific DNA binding
S1001342_01698	COG3145	DNA-N1-methyladenine dioxygenase activity
S1001342_01702	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
S1001342_01704	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
S1001342_01705	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
S1001342_01707	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
S1001342_01709	COG0284	orotidine-5'-phosphate decarboxylase activity
S1001342_01713	COG1953	Uracil, thiamine, allantoin
S1001342_01717	COG0493	'glutamate synthase
S1001342_01720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S1001342_01722	COG1942	4-Oxalocrotonate Tautomerase
S1001342_01723	COG4993	Dehydrogenase
S1001342_01725	COG1113	amino acid transport
S1001342_01728	COG1271	oxidase subunit
S1001342_01729	COG1294	oxidase, subunit
S1001342_01735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S1001342_01735	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S1001342_01736	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S1001342_01737	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
S1001342_01738	COG1120	ATPase activity
S1001342_01739	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S1001342_01740	COG0564	pseudouridine synthase activity
S1001342_01741	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S1001342_01743	COG1494	fructose-1,6-bisphosphatase
S1001342_01745	COG0436	Aminotransferase
S1001342_01747	COG0740	serine-type endopeptidase activity
S1001342_01749	COG0535	radical SAM domain protein
S1001342_01751	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
S1001342_01752	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S1001342_01756	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S1001342_01757	COG0708	Exodeoxyribonuclease III
S1001342_01758	COG0316	Belongs to the HesB IscA family
S1001342_01759	COG0232	Belongs to the dGTPase family. Type 2 subfamily
S1001342_01760	COG0018	arginyl-trna synthetase
S1001342_01762	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S1001342_01763	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S1001342_01764	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S1001342_01765	COG0805	protein transport
S1001342_01766	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S1001342_01768	COG4232	protein-disulfide reductase activity
S1001342_01795	COG1396	sequence-specific DNA binding
S1001342_01798	COG0629	single-stranded DNA binding
S1001342_01802	COG3750	Belongs to the UPF0335 family
S1001342_01854	COG1289	transmembrane transporter activity
S1001342_01855	COG0583	DNA-binding transcription factor activity
S1001342_01867	COG3293	Transposase
S1001342_01871	COG1999	signal sequence binding
S1001342_01873	COG0028	Belongs to the TPP enzyme family
S1001342_01874	COG1028	Short-chain dehydrogenase reductase Sdr
S1001342_01877	COG0297	glycogen (starch) synthase activity
S1001342_01878	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S1001342_01879	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S1001342_01881	COG0300	oxidoreductase activity
S1001342_01886	COG0439	Biotin carboxylase
S1001342_01888	COG4221	oxidoreductase activity
S1001342_01890	COG1984	allophanate hydrolase subunit 2
S1001342_01891	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S1001342_01892	COG0697	spore germination
S1001342_01900	COG0583	DNA-binding transcription factor activity
S1001342_01902	COG0431	NADPH-dependent FMN reductase
S1001342_01904	COG2814	Major facilitator Superfamily
S1001342_01905	COG1012	belongs to the aldehyde dehydrogenase family
S1001342_01906	COG1252	NADH dehydrogenase
S1001342_01908	COG1309	transcriptional regulator
S1001342_01913	COG2308	Evidence 4 Homologs of previously reported genes of
S1001342_01916	COG0277	FAD linked oxidase domain protein
S1001342_01922	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
S1001342_01924	COG0424	maF-like protein
S1001342_01925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S1001342_01926	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S1001342_01927	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S1001342_01928	COG1530	ribonuclease E activity
S1001342_01938	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S1001342_01939	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S1001342_01940	COG0328	RNA-DNA hybrid ribonuclease activity
S1001342_01943	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S1001342_01947	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S1001342_01948	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S1001342_01951	COG0745	RESPONSE REGULATOR receiver
S1001342_01953	COG0488	(ABC) transporter
S1001342_01954	COG0105	UTP biosynthetic process
S1001342_01955	COG1032	radical SAM domain protein
S1001342_01956	COG3161	chorismate lyase activity
S1001342_01961	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S1001342_01966	COG0251	oxidation-reduction process
S1001342_01967	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S1001342_01968	COG0587	DNA-directed DNA polymerase activity
S1001342_01974	COG0052	Belongs to the universal ribosomal protein uS2 family
S1001342_01975	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S1001342_01976	COG1381	Involved in DNA repair and RecF pathway recombination
S1001342_01977	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S1001342_01978	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
S1001342_01979	COG0113	porphobilinogen synthase activity
S1001342_01980	COG0531	amino acid
S1001342_01981	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S1001342_01982	COG2988	succinylglutamate desuccinylase activity
S1001342_01985	COG0513	Belongs to the DEAD box helicase family
S1001342_01988	COG0560	Phosphoserine phosphatase
S1001342_01989	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S1001342_01990	COG0028	Belongs to the TPP enzyme family
S1001342_01992	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S1001342_01994	COG2132	Multicopper oxidase
S1001342_01998	COG1335	isochorismatase
S1001342_01999	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S1001342_02002	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
S1001342_02006	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S1001342_02007	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S1001342_02007	COG0574	Belongs to the PEP-utilizing enzyme family
S1001342_02008	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S1001342_02009	COG0497	DNA recombination
S1001342_02010	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S1001342_02013	COG0849	cell division
S1001342_02014	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S1001342_02015	COG1181	Belongs to the D-alanine--D-alanine ligase family
S1001342_02016	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S1001342_02017	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S1001342_02018	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S1001342_02020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S1001342_02021	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S1001342_02023	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S1001342_02026	COG0275	rRNA processing
S1001342_02027	COG2001	Belongs to the MraZ family
S1001342_02031	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S1001342_02032	COG3750	Belongs to the UPF0335 family
S1001342_02034	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S1001342_02035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S1001342_02036	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S1001342_02037	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S1001342_02042	COG3293	Transposase
S1001342_02044	COG1216	Glycosyl transferase, family 2
S1001342_02054	COG2252	PERMEase
S1001342_02058	COG0723	plastoquinol--plastocyanin reductase activity
S1001342_02059	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S1001342_02059	COG2857	Cytochrome c1
S1001342_02060	COG2857	Cytochrome c1
S1001342_02060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S1001342_02062	COG0307	riboflavin synthase, alpha
S1001342_02063	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S1001342_02063	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S1001342_02064	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S1001342_02070	COG1566	PFAM secretion protein HlyD family protein
S1001342_02076	COG0521	Mo-molybdopterin cofactor biosynthetic process
S1001342_02078	COG0302	gtp cyclohydrolase
S1001342_02079	COG2967	ApaG domain
S1001342_02082	COG0494	nUDIX hydrolase
S1001342_02087	COG4974	Belongs to the 'phage' integrase family
S1001342_02091	COG0004	ammonium transporteR
S1001342_02097	COG4372	Transposase
S1001342_02098	COG4372	Transposase
S1001342_02100	COG2963	transposase activity
S1001342_02112	COG0459	protein refolding
S1001342_02113	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S1001342_02114	COG0412	Dienelactone hydrolase
S1001342_02115	COG1278	Cold shock
S1001342_02116	COG1199	ATP-dependent helicase activity
S1001342_02117	COG0483	inositol monophosphate 1-phosphatase activity
S1001342_02118	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S1001342_02120	COG3547	Transposase (IS116 IS110 IS902 family)
S1001342_02126	COG0586	Pfam SNARE associated Golgi protein
S1001342_02128	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S1001342_02130	COG0347	Belongs to the P(II) protein family
S1001342_02131	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S1001342_02134	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S1001342_02136	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
S1001342_02146	COG2963	transposase activity
S1001342_02148	COG4372	Transposase
S1001342_02149	COG0463	Glycosyl transferase, family 2
S1001342_02150	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S1001342_02150	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S1001342_02155	COG2204	response regulator
S1001342_02156	COG1923	regulation of RNA biosynthetic process
S1001342_02157	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S1001342_02158	COG1051	belongs to the nudix hydrolase family
S1001342_02160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S1001342_02164	COG0659	secondary active sulfate transmembrane transporter activity
S1001342_02165	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
S1001342_02166	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S1001342_02169	COG0438	transferase activity, transferring glycosyl groups
S1001342_02175	COG1160	GTP binding
S1001342_02176	COG2814	Major facilitator Superfamily
S1001342_02177	COG3572	ergothioneine biosynthetic process
S1001342_02181	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S1001342_02182	COG0564	pseudouridine synthase activity
S1001342_02187	COG0228	four-way junction DNA binding
S1001342_02188	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S1001342_02189	COG0336	Belongs to the RNA methyltransferase TrmD family
S1001342_02190	COG0335	large ribosomal subunit rRNA binding
S1001342_02191	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S1001342_02192	COG0066	3-isopropylmalate dehydratase activity
S1001342_02193	COG0473	3-isopropylmalate dehydrogenase activity
S1001342_02194	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S1001342_02195	COG0242	peptide deformylase activity
S1001342_02197	COG1846	Transcriptional regulator
S1001342_02198	COG0745	RESPONSE REGULATOR receiver
S1001342_02199	COG2205	protein histidine kinase activity
S1001342_02202	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S1001342_02203	COG0416	fatty acid biosynthetic process
S1001342_02204	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S1001342_02205	COG0776	regulation of translation
S1001342_02208	COG0628	permease
S1001342_02211	COG0776	regulation of translation
S1001342_02212	COG4957	zinc ion binding
S1001342_02213	COG0583	DNA-binding transcription factor activity
S1001342_02214	COG0492	ferredoxin-NADP+ reductase activity
S1001342_02215	COG1522	sequence-specific DNA binding
S1001342_02219	COG2226	methyltransferase
S1001342_02221	COG0109	protoheme IX farnesyltransferase activity
S1001342_02225	COG0312	modulator of DNA gyrase
S1001342_02226	COG0612	Peptidase, M16
S1001342_02231	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S1001342_02232	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
S1001342_02234	COG5265	(ABC) transporter
S1001342_02236	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S1001342_02237	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S1001342_02239	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
S1001342_02240	COG2733	membrane
S1001342_02242	COG0719	Fe-S assembly protein
S1001342_02243	COG0396	ATPase activity
S1001342_02244	COG0719	Fe-S assembly protein
S1001342_02245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S1001342_02247	COG2151	metal-sulfur cluster biosynthetic enzyme
S1001342_02249	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S1001342_02250	COG0513	Belongs to the DEAD box helicase family
S1001342_02252	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S1001342_02252	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
S1001342_02254	COG0544	peptidyl-prolyl cis-trans isomerase activity
S1001342_02255	COG0740	serine-type endopeptidase activity
S1001342_02256	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S1001342_02258	COG0776	regulation of translation
S1001342_02262	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S1001342_02263	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S1001342_02264	COG0649	NAD binding
S1001342_02265	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
S1001342_02267	COG1034	ATP synthesis coupled electron transport
S1001342_02268	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
S1001342_02269	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
S1001342_02271	COG0713	ATP synthesis coupled electron transport
S1001342_02273	COG1007	ATP synthesis coupled electron transport
S1001342_02275	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S1001342_02277	COG0442	prolyl-tRNA aminoacylation
S1001342_02279	COG1136	(ABC) transporter
S1001342_02280	COG0386	Belongs to the glutathione peroxidase family
S1001342_02283	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S1001342_02284	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S1001342_02285	COG0546	phosphoglycolate phosphatase activity
S1001342_02290	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S1001342_02293	COG0156	8-amino-7-oxononanoate synthase activity
S1001342_02295	COG0318	PFAM AMP-dependent synthetase and ligase
S1001342_02309	COG1126	abc transporter atp-binding protein
S1001342_02310	COG0765	amino acid transport
S1001342_02312	COG1834	amidinotransferase
S1001342_02313	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S1001342_02315	COG1231	oxidoreductase activity
S1001342_02319	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S1001342_02321	COG1914	H( )-stimulated, divalent metal cation uptake system
S1001342_02322	COG2814	Major facilitator Superfamily
S1001342_02328	COG1064	alcohol dehydrogenase
S1001342_02332	COG0583	DNA-binding transcription factor activity
S1001342_02333	COG0488	(ABC) transporter
S1001342_02339	COG2985	domain, Protein
S1001342_02341	COG0252	asparaginase activity
S1001342_02347	COG4774	siderophore transport
S1001342_02348	COG3128	pkhd-type hydroxylase
S1001342_02349	COG4988	ABC transporter
S1001342_02350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S1001342_02351	COG1271	oxidase subunit
S1001342_02352	COG1294	oxidase, subunit
S1001342_02356	COG0668	transmembrane transport
S1001342_02360	COG1032	radical SAM domain protein
S1001342_02362	COG1289	transmembrane transporter activity
S1001342_02363	COG1566	PFAM secretion protein HlyD family protein
S1001342_02366	COG1695	Transcriptional regulator
S1001342_02368	COG0477	Major facilitator Superfamily
S1001342_02377	COG3511	phospholipase C
S1001342_02380	COG0671	phosphoesterase, PA-phosphatase related
S1001342_02381	COG2070	2-Nitropropane dioxygenase
S1001342_02382	COG4608	Belongs to the ABC transporter superfamily
S1001342_02388	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S1001342_02388	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S1001342_02391	COG0745	RESPONSE REGULATOR receiver
S1001342_02427	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
S1001342_02436	COG0616	signal peptide processing
S1001342_02444	COG4386	tail sheath protein
S1001342_02451	COG4381	Mu-like prophage protein gp46
S1001342_02468	COG0180	Tryptophanyl-tRNA synthetase
S1001342_02470	COG0545	Peptidyl-prolyl cis-trans isomerase
S1001342_02471	COG0137	argininosuccinate synthase activity
S1001342_02472	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S1001342_02474	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S1001342_02475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S1001342_02476	COG0142	geranyltranstransferase activity
S1001342_02477	COG1722	exodeoxyribonuclease VII activity
S1001342_02478	COG0425	Belongs to the sulfur carrier protein TusA family
S1001342_02479	COG1940	carbohydrate kinase activity
S1001342_02480	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
S1001342_02481	COG0248	Ppx GppA phosphatase
S1001342_02483	COG3383	formate dehydrogenase (NAD+) activity
S1001342_02483	COG0243	molybdopterin cofactor binding
S1001342_02484	COG0437	4 iron, 4 sulfur cluster binding
S1001342_02485	COG2864	formate dehydrogenase
S1001342_02486	COG3058	Necessary for formate dehydrogenase activity
S1001342_02487	COG0303	'Molybdopterin
S1001342_02488	COG1763	Mo-molybdopterin cofactor biosynthetic process
S1001342_02490	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S1001342_02492	COG1971	Probably functions as a manganese efflux pump
S1001342_02495	COG0493	'glutamate synthase
S1001342_02501	COG0628	permease
S1001342_02514	COG0114	fumarate hydratase activity
S1001342_02524	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
S1001342_02525	COG2814	Major facilitator Superfamily
S1001342_02526	COG2999	glutathione oxidoreductase activity
S1001342_02527	COG0500	methyltransferase
S1001342_02528	COG1301	dicarboxylic acid transport
S1001342_02541	COG0667	Aldo Keto reductase
S1001342_02542	COG4372	Transposase
S1001342_02544	COG2963	transposase activity
S1001342_02545	COG0667	Aldo Keto reductase
S1001342_02550	COG1231	oxidoreductase activity
S1001342_02554	COG1960	acyl-CoA dehydrogenase activity
S1001342_02564	COG4178	(ABC) transporter
S1001342_02571	COG3459	Glycosyltransferase 36 associated
S1001342_02574	COG0753	catalase activity
S1001342_02575	COG1733	regulation of RNA biosynthetic process
S1001342_02576	COG1902	pentaerythritol trinitrate reductase activity
S1001342_02577	COG1012	belongs to the aldehyde dehydrogenase family
S1001342_02578	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
S1001342_02582	COG1657	PFAM Prenyltransferase squalene oxidase
S1001342_02584	COG3293	Transposase
S1001342_02586	COG2855	membrane
S1001342_02591	COG0842	Transport permease protein
S1001342_02592	COG0842	Transport permease protein
S1001342_02592	COG1129	ABC transporter
S1001342_02593	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S1001342_02600	COG0402	S-adenosylhomocysteine deaminase activity
S1001342_02602	COG2072	flavoprotein involved in K transport
S1001342_02605	COG2351	hydroxyisourate hydrolase activity
S1001342_02606	COG2233	PERMEase
S1001342_02608	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S1001342_02613	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S1001342_02620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S1001342_02620	COG1116	anion transmembrane transporter activity
S1001342_02624	COG0384	phenazine biosynthesis protein PhzF
S1001342_02626	COG0814	amino acid
S1001342_02627	COG2824	Alkylphosphonate utilization operon protein PhnA
S1001342_02631	COG0784	Response regulator, receiver
S1001342_02636	COG4988	ABC transporter
S1001342_02637	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S1001342_02640	COG1349	DNA-binding transcription factor activity
S1001342_02642	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S1001342_02643	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S1001342_02645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S1001342_02646	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S1001342_02647	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S1001342_02648	COG0456	acetyltransferase
S1001342_02649	COG4221	oxidoreductase activity
S1001342_02654	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
S1001342_02657	COG0525	valine-tRNA ligase activity
S1001342_02658	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S1001342_02659	COG1116	anion transmembrane transporter activity
S1001342_02660	COG1176	ABC-type spermidine putrescine transport system, permease component I
S1001342_02661	COG0756	dUTP diphosphatase activity
S1001342_02662	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S1001342_02663	COG2226	methyltransferase
S1001342_02664	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S1001342_02665	COG0268	Binds directly to 16S ribosomal RNA
S1001342_02671	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S1001342_02675	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
S1001342_02694	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
S1001342_02707	COG1294	oxidase, subunit
S1001342_02708	COG1271	oxidase subunit
S1001342_02722	COG3547	Transposase (IS116 IS110 IS902 family)
S1001342_02733	COG1959	2 iron, 2 sulfur cluster binding
S1001342_02734	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S1001342_02734	COG1017	nitric oxide dioxygenase activity
S1001342_02740	COG3256	nitric oxide reductase
S1001342_02757	COG0583	DNA-binding transcription factor activity
S1001342_02758	COG3293	Transposase
S1001342_02761	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
S1001342_02762	COG2072	flavoprotein involved in K transport
S1001342_02763	COG0431	NADPH-dependent FMN reductase
S1001342_02767	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
S1001342_02769	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
S1001342_02777	COG3547	Transposase (IS116 IS110 IS902 family)
S1001342_02787	COG1959	2 iron, 2 sulfur cluster binding
S1001342_02788	COG0789	Transcriptional regulator
S1001342_02797	COG0431	NADPH-dependent FMN reductase
S1001342_02798	COG2072	flavoprotein involved in K transport
S1001342_02824	COG2337	Toxic component of a toxin-antitoxin (TA) module
S1001342_02825	COG2336	PFAM SpoVT AbrB
S1001342_02827	COG3547	Transposase (IS116 IS110 IS902 family)
S1001342_02831	COG4974	Belongs to the 'phage' integrase family
S1001342_02834	COG2894	cell division
S1001342_02845	COG0583	DNA-binding transcription factor activity
S1001342_02846	COG1028	Short-chain dehydrogenase reductase Sdr
S1001342_02848	COG2072	flavoprotein involved in K transport
S1001342_02851	COG2144	transferase activity, transferring acyl groups
S1001342_02856	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S1001342_02858	COG0583	DNA-binding transcription factor activity
S1001342_02869	COG0745	RESPONSE REGULATOR receiver
S1001342_02870	COG0642	Histidine kinase
S1001342_02872	COG2223	nitrite transmembrane transporter activity
S1001342_02874	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S1001342_02874	COG2146	nitrite reductase [NAD(P)H] activity
S1001342_02875	COG0243	molybdopterin cofactor binding
S1001342_02877	COG3293	Transposase
S1001342_02881	COG0243	molybdopterin cofactor binding
S1001342_02885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S1001342_02885	COG1116	anion transmembrane transporter activity
S1001342_02889	COG2072	flavoprotein involved in K transport
S1001342_02890	COG1012	belongs to the aldehyde dehydrogenase family
S1001342_02892	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S1001342_02895	COG1979	alcohol dehydrogenase
S1001342_02896	COG1012	belongs to the aldehyde dehydrogenase family
S1001342_02902	COG1959	2 iron, 2 sulfur cluster binding
S1001342_02904	COG1028	Short-chain dehydrogenase reductase Sdr
S1001342_02906	COG0745	RESPONSE REGULATOR receiver
S1001342_02907	COG2205	protein histidine kinase activity
S1001342_02908	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
S1001342_02909	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
S1001342_02910	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
S1001342_02915	COG1012	belongs to the aldehyde dehydrogenase family
S1001342_02916	COG1979	alcohol dehydrogenase
S1001342_02917	COG1309	transcriptional regulator
S1001342_02925	COG3158	transport of potassium into the cell
S1001342_02929	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S1001342_02931	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S1001342_02936	COG2197	response regulator
S1001342_02942	COG1999	signal sequence binding
S1001342_02943	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
S1001342_02945	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
S1001342_02946	COG0732	type I restriction modification DNA specificity domain
S1001342_02947	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
S1001342_02951	COG4957	zinc ion binding
S1001342_02955	COG3547	Transposase (IS116 IS110 IS902 family)
S1001342_02976	COG1321	iron dependent repressor
S1001342_02977	COG1914	H( )-stimulated, divalent metal cation uptake system
S1001342_02986	COG3293	Transposase
S1001342_02988	COG1403	HNH endonuclease
S1001342_02995	COG3547	Transposase (IS116 IS110 IS902 family)
S1001342_03003	COG1192	Involved in chromosome partitioning
S1001342_03004	COG1475	DNA binding
S1001342_03012	COG4227	nucleotidyltransferase activity
S1001342_03015	COG0629	single-stranded DNA binding
S1001342_03019	COG0210	DNA helicase
S1001342_03024	COG3403	YqcI/YcgG family
S1001342_03031	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S1001342_03032	COG0210	DNA helicase
S1001342_03037	COG4974	Belongs to the 'phage' integrase family
S1001342_03055	COG0629	single-stranded DNA binding
S1001342_03083	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S1001342_03109	COG3750	Belongs to the UPF0335 family
S1001342_03110	COG0640	Transcriptional regulator
S1001342_03112	COG2184	nucleotidyltransferase activity
S1001342_03122	COG1403	HNH endonuclease
S1001342_03128	COG2801	Transposase and inactivated derivatives
S1001342_03135	COG3547	Transposase (IS116 IS110 IS902 family)
S1001342_03136	COG2814	Major facilitator Superfamily
S1001342_03137	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
S1001342_03144	COG4957	zinc ion binding
S1001342_03153	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
S1001342_03154	COG0732	type I restriction modification DNA specificity domain
S1001342_03155	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
S1001342_03157	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
S1001342_03165	COG1309	transcriptional regulator
S1001342_03170	COG4691	Plasmid stability protein
S1001342_03171	COG1487	ribonuclease activity
S1001342_03178	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S1001342_03184	COG0675	Transposase, IS605 OrfB family
S1001342_03215	COG3299	homolog of phage Mu protein gp47
S1001342_03226	COG2026	Addiction module toxin, RelE StbE family
S1001342_03227	COG3077	Addiction module antitoxin, RelB DinJ family