locus-tag class description A0U91_00055 ENOG410630Q Methylamine utilization A0U91_00060 ENOG4108YF6 methylamine dehydrogenase accessory protein MauD A0U91_00065 ENOG4108XDC Dehydrogenase A0U91_00080 ENOG4108YF6 methylamine dehydrogenase accessory protein MauD A0U91_00110 ENOG4105C2I pirin domain protein A0U91_00120 ENOG4105CC0 LysR family Transcriptional regulator A0U91_00125 ENOG4105EUB pirin domain protein A0U91_00130 ENOG4108YYH Nadph-dependent fmn reductase A0U91_00135 ENOG4105HSS phospholipase C A0U91_00140 ENOG4106HK8 GPR1 FUN34 yaaH family protein A0U91_00325 ENOG4105ENJ RND efflux system, outer membrane lipoprotein A0U91_00330 ENOG4105CMI transporter A0U91_00335 ENOG4105CJ1 ABC, transporter A0U91_00340 ENOG4105D0S secretion protein (HlyD A0U91_00350 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) A0U91_00355 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) A0U91_00370 ENOG4105CJ3 phosphate transporter A0U91_00380 ENOG4105F27 Major Facilitator A0U91_00395 ENOG4105DUX Transporter A0U91_00410 ENOG4107XBN GntR Family Transcriptional Regulator A0U91_00415 ENOG4107QTZ amino acid A0U91_00430 ENOG4105DC7 peptidase M24 A0U91_00440 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A0U91_00455 ENOG4105CTU Proline racemase A0U91_00460 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A0U91_00500 ENOG4107RSM transcriptional regulator A0U91_00505 ENOG4105DSW Fusaric acid resistance protein A0U91_00510 ENOG41069B0 Membrane-bound lysozyme-inhibitor of c-type lysozyme A0U91_00520 ENOG4105C31 Tryptophanyl-tRNA synthetase A0U91_00530 ENOG4108V1T peptidylprolyl cis-trans isomerase A0U91_00535 ENOG4105CDH Citrulline--aspartate ligase A0U91_00540 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs A0U91_00550 ENOG4105DX0 Hemolysin A A0U91_00555 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) A0U91_00560 ENOG4105CTB Polyprenyl synthetase A0U91_00565 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A0U91_00570 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) A0U91_00575 ENOG4105DKQ ROK family A0U91_00580 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) A0U91_00585 ENOG4105C9X ppx gppa phosphatase A0U91_00630 ENOG4105C6F GntR Family Transcriptional Regulator A0U91_00640 ENOG4105C5R Aminotransferase A0U91_00655 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) A0U91_00660 ENOG4107QUY Guanine deaminase A0U91_00665 ENOG4105DDW LysR family Transcriptional regulator A0U91_00670 ENOG4105E1J oxidoreductase A0U91_00685 ENOG4105VT2 5-hydroxyisourate hydrolase A0U91_00705 ENOG4105C7W Xanthine dehydrogenase A0U91_00725 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) A0U91_00730 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein A0U91_00735 ENOG4108MG3 formate dehydrogenase A0U91_00740 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) A0U91_00750 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b A0U91_00760 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) A0U91_00795 ENOG4105CAU Arsenical resistance protein, ArsH A0U91_01050 ENOG4105BZS acriflavin resistance protein A0U91_01060 ENOG41062D9 Histidine kinase A0U91_01070 ENOG4108KQ5 Integrase catalytic subunit A0U91_01090 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A0U91_01190 ENOG4105MP0 transposase A0U91_01200 ENOG4105C22 threonyL-tRNA synthetase A0U91_01210 ENOG4105EUJ GTP cyclohydrolase i A0U91_01215 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase A0U91_01220 ENOG4105CKI cobalamin synthesis protein A0U91_01250 ENOG4105C1Q protoporphyrinogen oxidase A0U91_01265 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr A0U91_01270 ENOG4105EJC lysr family transcriptional regulator A0U91_01290 ENOG4105CF7 AraC family transcriptional regulator A0U91_01295 ENOG4108IXY short-chain dehydrogenase reductase A0U91_01305 ENOG4105CHR reductase A0U91_01310 ENOG4105F2W methyltransferase A0U91_01355 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A0U91_01380 ENOG4105D05 Receptor A0U91_01400 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) A0U91_01430 ENOG4105FDP GntR family transcriptional regulator A0U91_01460 ENOG4105D3W isochorismatase A0U91_01465 ENOG4105C0R drug resistance transporter emrb qaca subfamily A0U91_01480 ENOG4105C6V Glycerol-3-phosphate dehydrogenase A0U91_01485 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) A0U91_01515 ENOG4105D01 (LipO)protein A0U91_01525 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A0U91_01530 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) A0U91_01535 ENOG4108UMI ABC transporter, permease A0U91_01545 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) A0U91_01550 ENOG4105DHU Bile acid A0U91_01565 ENOG4107NQ8 LysR family Transcriptional regulator A0U91_01575 ENOG4105DFG type I secretion outer membrane protein A0U91_01580 ENOG4107RBB ABC transporter, permease A0U91_01585 ENOG4105C19 ABC transporter A0U91_01610 ENOG4105CC0 LysR family Transcriptional regulator A0U91_01615 ENOG4107SQD Transcriptional regulator, GntR family A0U91_01655 ENOG4105H3G oxidoreductase A0U91_01660 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A0U91_01680 ENOG4105EQ2 LysR family Transcriptional regulator A0U91_01690 ENOG4105EMU Dehydrogenase A0U91_01695 ENOG4107RTG Major Facilitator superfamily A0U91_01710 ENOG4105E2K Glycosyl transferase (Group 1 A0U91_01715 ENOG4105CG5 Glycosyl transferase (Group 1 A0U91_01735 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) A0U91_01740 ENOG4105BZU Histidine kinase A0U91_01765 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) A0U91_01770 ENOG4105KST dependent repressor A0U91_01800 ENOG4108K3A Glutathione S-transferase A0U91_01810 ENOG4105C5H ABC transporter A0U91_01815 ENOG41074H6 response regulator A0U91_01840 ENOG4108JJ9 ABC, transporter A0U91_01845 ENOG4108JJ8 (ABC) transporter A0U91_01855 ENOG4105C9U ATP-dependent DNA helicase RecQ A0U91_01865 ENOG4105C6V Glycerol-3-phosphate dehydrogenase A0U91_01870 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) A0U91_01875 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) A0U91_01885 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) A0U91_01890 ENOG4107XZX Involved in the transcription termination process (By similarity) A0U91_01895 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) A0U91_01920 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) A0U91_01925 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) A0U91_01935 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component A0U91_01945 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase A0U91_01950 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A0U91_01955 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) A0U91_01960 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) A0U91_01965 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) A0U91_01970 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A0U91_01975 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) A0U91_01985 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase A0U91_01990 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) A0U91_02000 ENOG4105CP7 Triose-phosphate isomerase A0U91_02015 ENOG4105DDQ anthranilate synthase A0U91_02025 ENOG4105DK0 Indole-3-glycerol phosphate synthase A0U91_02030 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A0U91_02035 ENOG4108JYK Dehydrogenase A0U91_02040 ENOG4105CPP Dehydrogenase, E1 component A0U91_02045 ENOG4105C7S Dehydrogenase A0U91_02050 ENOG4107QN2 dihydrolipoyl dehydrogenase A0U91_02055 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) A0U91_02060 ENOG4108Z1B Cyclase dehydrase A0U91_02070 ENOG4107TH8 cina domain protein A0U91_02075 ENOG4108ZAI phosphatidylglycerophosphatase a A0U91_02080 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division A0U91_02085 ENOG4108ZCF integral membrane protein A0U91_02090 ENOG4105C83 adenylosuccinate lyase A0U91_02095 ENOG4107QPR SAICAR synthetase A0U91_02100 ENOG4105VR9 phosphoribosylformylglycinamidine synthase A0U91_02110 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I A0U91_02115 ENOG4107QIK phosphoribosylformylglycinamidine synthase A0U91_02135 ENOG41082FP UPF0102 protein A0U91_02140 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A0U91_02160 ENOG4105KHC sulfurtransferase A0U91_02165 ENOG4105C28 cystathionine A0U91_02170 ENOG4105C0P Mg chelatase subunit ChlI A0U91_02175 ENOG4108JQ1 Dehydrogenase A0U91_02190 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) A0U91_02195 ENOG4105CQC Prephenate dehydratase A0U91_02200 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A0U91_02205 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) A0U91_02210 ENOG4105VEQ Cold shock protein A0U91_02240 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A0U91_02250 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) A0U91_02255 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) A0U91_02260 ENOG4105HHA aminodeoxychorismate lyase A0U91_02280 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) A0U91_02285 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase A0U91_02295 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) A0U91_02305 ENOG4108IJ6 ABC transporter A0U91_02310 ENOG4105ECW sulfate abc transporter A0U91_02315 ENOG4108I5D sulfate abc transporter A0U91_02330 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) A0U91_02340 ENOG4105CBN LysR family transcriptional regulator A0U91_02345 ENOG4105H9W Short-chain dehydrogenase reductase Sdr A0U91_02355 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) A0U91_02365 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) A0U91_02375 ENOG4105DWT malate dehydrogenase (quinone) A0U91_02380 ENOG4108Z9K Osmotically inducible protein A0U91_02385 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase A0U91_02390 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH A0U91_02395 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) A0U91_02410 ENOG4105F8V Hydrolase, tatD family A0U91_02425 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) A0U91_02430 ENOG4105DZ1 carboxypeptidase A0U91_02445 ENOG4108VD1 dedA family A0U91_02455 ENOG4105CUB amino acid A0U91_02460 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) A0U91_02465 ENOG4107PE3 Mammalian cell entry related domain protein A0U91_02480 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) A0U91_02490 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) A0U91_02500 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) A0U91_02510 ENOG4105EA8 2-Nitropropane dioxygenase A0U91_02515 ENOG4105CFH Aspartokinase A0U91_02520 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) A0U91_02525 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) A0U91_02540 ENOG41090BQ Glutaredoxin A0U91_02545 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) A0U91_02575 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) A0U91_02620 ENOG4105DY8 decarboxylase A0U91_02625 ENOG4105DHU Bile acid A0U91_02650 ENOG4107NKQ Flavinator of succinate dehydrogenase A0U91_02655 ENOG4105CB5 ATP-dependent DNA helicase recG A0U91_02665 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) A0U91_02695 ENOG4105W0E 50S ribosomal protein L33 A0U91_02710 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) A0U91_02715 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) A0U91_02735 ENOG4108ZAF Molybdopterin A0U91_02740 ENOG4105M00 molybdopterin converting factor, subunit 1 A0U91_02755 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) A0U91_02760 ENOG4108IGT Dipeptidase A0U91_02775 ENOG4105CFU surface antigen A0U91_02785 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A0U91_02800 ENOG4105C37 (CBS) domain A0U91_02805 ENOG4108R9S DSBA oxidoreductase A0U91_02830 ENOG4105EHE chorismate mutase- prephenate dehydrogenase A0U91_02855 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) A0U91_02860 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) A0U91_02865 ENOG4105EAH synthase A0U91_02875 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A0U91_02880 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A0U91_02890 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A0U91_02905 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) A0U91_02910 ENOG41082FS 50S ribosomal protein L31 A0U91_02915 ENOG4108ZNX Heat shock protein A0U91_02935 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit A0U91_02940 ENOG4105W5Q DNA repair protein (RadC A0U91_02945 ENOG4105W5Q DNA repair protein (RadC A0U91_02950 ENOG4105C4R Atp-dependent dna helicase A0U91_02955 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) A0U91_02960 ENOG4105DC7 peptidase M24 A0U91_02965 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A0U91_02975 ENOG4105EQ0 Major Facilitator superfamily A0U91_02980 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) A0U91_02985 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) A0U91_03015 ENOG4105C9Q fumarate hydratase class II A0U91_03020 ENOG4105DEF Extracellular solute-binding protein, family 5 A0U91_03030 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) A0U91_03035 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) A0U91_03040 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) A0U91_03045 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) A0U91_03050 ENOG41082BR 50S ribosomal protein L35 A0U91_03055 ENOG4105DEI Mannitol dehydrogenase A0U91_03080 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) A0U91_03085 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) A0U91_03090 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) A0U91_03115 ENOG4105CAK Cell division ATP-binding protein ftsE A0U91_03135 ENOG4105C4W S-formylglutathione hydrolase A0U91_03140 ENOG4105FFC UPF0187 protein A0U91_03165 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) A0U91_03170 ENOG4105CBX hi0933 family A0U91_03180 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) A0U91_03185 ENOG4107QMS site-determining protein A0U91_03190 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) A0U91_03195 ENOG4108WYP Transcriptional regulator A0U91_03200 ENOG4105BZ1 (ABC) transporter A0U91_03205 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A0U91_03215 ENOG4105CV8 reductase A0U91_03255 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase A0U91_03260 ENOG4105K9Q Binds to the 23S rRNA (By similarity) A0U91_03265 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) A0U91_03270 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) A0U91_03280 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A0U91_03285 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) A0U91_03295 ENOG4105KY5 gCN5-related N-acetyltransferase A0U91_03315 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) A0U91_03320 ENOG4105C7B Threonine dehydratase A0U91_03325 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) A0U91_03335 ENOG4105CN1 protease A0U91_03350 ENOG4105C0R drug resistance transporter emrb qaca subfamily A0U91_03360 ENOG4105BZ1 (ABC) transporter A0U91_03365 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate A0U91_03375 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A0U91_03400 ENOG4105CEC DNA methylase N-4 N-6 A0U91_03405 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A0U91_03415 ENOG4105C0R drug resistance transporter emrb qaca subfamily A0U91_03420 ENOG4105ENT Efflux transporter rnd family, mfp subunit A0U91_03425 ENOG4105BZS acriflavin resistance protein A0U91_03435 ENOG4105ENJ RND efflux system, outer membrane lipoprotein A0U91_03455 ENOG4108IY8 ABC, transporter A0U91_03475 ENOG4108ZT0 50S ribosomal protein l17 A0U91_03480 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A0U91_03485 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) A0U91_03490 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits A0U91_03495 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) A0U91_03505 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) A0U91_03510 ENOG41084HQ 50S ribosomal protein L30 A0U91_03515 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) A0U91_03520 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) A0U91_03525 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) A0U91_03530 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) A0U91_03535 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) A0U91_03540 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits A0U91_03545 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) A0U91_03550 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) A0U91_03555 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal A0U91_03560 ENOG41083MP 50s ribosomal protein l29 A0U91_03565 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) A0U91_03570 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) A0U91_03575 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) A0U91_03580 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) A0U91_03585 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity A0U91_03590 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) A0U91_03595 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) A0U91_03600 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) A0U91_03605 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) A0U91_03610 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) A0U91_03615 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) A0U91_03620 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) A0U91_03625 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A0U91_03630 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A0U91_03635 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) A0U91_03640 ENOG4108VZM 50s ribosomal protein L10 A0U91_03645 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) A0U91_03650 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) A0U91_03655 ENOG4105ENJ RND efflux system, outer membrane lipoprotein A0U91_03670 ENOG4105DHQ Histidine kinase A0U91_03675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A0U91_03680 ENOG4107QSV RmuC domain protein A0U91_03690 ENOG4105CSH Transporter A0U91_03700 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A0U91_03735 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) A0U91_03790 ENOG41060IM Heme exporter protein A0U91_03795 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) A0U91_03800 ENOG4105DA4 cytochrome c-type biogenesis protein A0U91_03805 ENOG4107QX9 Thiol disulfide interChange protein A0U91_03830 ENOG4105CK2 sodium dicarboxylate symporter A0U91_03855 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A0U91_03860 ENOG4105DSW Fusaric acid resistance protein A0U91_03900 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) A0U91_03920 ENOG4108V3E phosphoribosylglycinamide formyltransferase A0U91_03930 ENOG4105DJV ribulose-phosphate 3-epimerase A0U91_03940 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) A0U91_03955 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) A0U91_03960 ENOG4105E2X shikimate dehydrogenase A0U91_03975 ENOG4105CH7 arginosuccinase A0U91_03990 ENOG4105CMR udp-glucose 4-epimerase A0U91_04000 ENOG4105YVS arsR family transcriptional regulator A0U91_04005 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A0U91_04020 ENOG4108R85 Short chain dehydrogenase A0U91_04025 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) A0U91_04030 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) A0U91_04035 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) A0U91_04040 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) A0U91_04055 ENOG4105CA0 peroxidase A0U91_04060 ENOG4105CEC DNA methylase N-4 N-6 A0U91_04075 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) A0U91_04095 ENOG4105D6S protein involved in catabolism of external DNA A0U91_04110 ENOG4105DK7 lysyl-tRNA synthetase A0U91_04115 ENOG4105CEV competence damage-inducible protein A0U91_04125 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A0U91_04140 ENOG4105D49 3-dehydroquinate synthase A0U91_04155 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A0U91_04160 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme A0U91_04170 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A0U91_04175 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A0U91_04235 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) A0U91_04255 ENOG4107QN2 dihydrolipoyl dehydrogenase A0U91_04260 ENOG4105C7S Dehydrogenase A0U91_04270 ENOG4105D6Z AFG1 family ATPase A0U91_04280 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 A0U91_04285 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) A0U91_04295 ENOG4105CD3 dihydroorotase A0U91_04300 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) A0U91_04310 ENOG4105C79 DNA protecting protein DprA A0U91_04320 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) A0U91_04350 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family A0U91_04365 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A0U91_04370 ENOG4107AQZ Membrane A0U91_04375 ENOG4105C8S subunit m A0U91_04395 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) A0U91_04400 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) A0U91_04405 ENOG4105DTN riboflavin biosynthesis protein ribF A0U91_04415 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) A0U91_04420 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) A0U91_04445 ENOG4105C8Y Acetylornithine aminotransferase A0U91_04450 ENOG4105DBV ornithine carbamoyltransferase A0U91_04460 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) A0U91_04475 ENOG4105CQ7 ATP-dependent helicase A0U91_04480 ENOG4105C0H protease A0U91_04490 ENOG4105CV8 reductase A0U91_04510 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A0U91_04515 ENOG4105C4M (Ubiquinol oxidase) subunit I A0U91_04530 ENOG4105D05 Receptor A0U91_04545 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) A0U91_04555 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A0U91_04590 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) A0U91_04635 ENOG4105C26 Dehydrogenase A0U91_04655 ENOG4105C7K acetolactate synthase A0U91_04675 ENOG4105C6Y Udp-glucose 6-dehydrogenase A0U91_04680 ENOG4105CY3 ABC transporter, permease A0U91_04725 ENOG4107SZR mannose-6-phosphate isomerase A0U91_04730 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) A0U91_04740 ENOG4107FW0 short-chain dehydrogenase reductase A0U91_04745 ENOG4105ETS cytosine purines uracil thiamine allantoin A0U91_04755 ENOG4108UPT UPF0178 protein A0U91_04765 ENOG4108RHM integral membrane protein A0U91_04775 ENOG4105C2X Arabinose 5-phosphate isomerase A0U91_04790 ENOG4108IUZ ABC transporter A0U91_04800 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea A0U91_04810 ENOG4108ZNX Heat shock protein A0U91_04820 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) A0U91_04825 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) A0U91_04830 ENOG4105EA8 2-Nitropropane dioxygenase A0U91_04835 ENOG4105DUM transcriptional regulator, lysR family A0U91_04840 ENOG4105HMI Membrane A0U91_04855 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) A0U91_04860 ENOG4105CAS nag kinase A0U91_04865 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) A0U91_04870 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins A0U91_04875 ENOG41087PG RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) A0U91_04880 ENOG4105VG0 50S ribosomal protein l34 A0U91_04890 ENOG4108UYE Lactoylglutathione lyase A0U91_04895 ENOG4105GYT Protein of unknown function (DUF1009) A0U91_04900 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) A0U91_04905 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) A0U91_04910 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) A0U91_04920 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane A0U91_04925 ENOG4105DZP Membrane-associated zinc metalloprotease A0U91_04930 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) A0U91_04940 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) A0U91_04945 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) A0U91_04950 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) A0U91_04955 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) A0U91_04960 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) A0U91_04965 ENOG4105C3F Signal peptidase i A0U91_04970 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) A0U91_04975 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) A0U91_04980 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) A0U91_04995 ENOG4107B2H carbonic anhydrase A0U91_05005 ENOG4105C1J atp-dependent rna helicase A0U91_05015 ENOG4105DWV Homoserine O-trans-acetylase A0U91_05025 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) A0U91_05055 ENOG4105DZG Dehydrogenase A0U91_05060 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) A0U91_05075 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A0U91_05080 ENOG4105C5F glutamine synthetase A0U91_05085 ENOG4108YZA Nitrogen regulatory protein pii A0U91_05100 ENOG41080TC multidrug resistance protein A0U91_05115 ENOG4105DUX Transporter A0U91_05140 ENOG4105CAY ferredoxin--nadp reductase A0U91_05150 ENOG4105CSR polyphosphate kinase 2 A0U91_05190 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A0U91_05195 ENOG4105MWK D-amino acid dehydrogenase, small subunit A0U91_05250 ENOG4105CI3 gtp-binding protein typa A0U91_05260 ENOG4105CE1 Ferrous iron transport protein b A0U91_05275 ENOG4108IU3 tonb-dependent siderophore receptor A0U91_05295 ENOG4105CA9 Pyruvate kinase A0U91_05310 ENOG4105D06 uba thif-type nad fad binding protein A0U91_05335 ENOG4105EPD Oligopeptide transporter, Opt family A0U91_05355 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 A0U91_05365 ENOG4108ESX Receptor A0U91_05395 ENOG4105E0K tonB-dependent siderophore receptor A0U91_05405 ENOG4108JJB ABC transporter A0U91_05420 ENOG4105PGM cation diffusion facilitator family transporter A0U91_05445 ENOG4105CKI cobalamin synthesis protein A0U91_05485 ENOG4105CKI cobalamin synthesis protein A0U91_05495 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 A0U91_05500 ENOG4105CPP Dehydrogenase, E1 component A0U91_05505 ENOG4107R0V Pyruvate dehydrogenase A0U91_05560 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase A0U91_05565 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) A0U91_05575 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) A0U91_05590 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) A0U91_05595 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) A0U91_05605 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) A0U91_05625 ENOG4105CF1 Alkylated DNA repair protein A0U91_05635 ENOG4108YYC ycei family A0U91_05640 ENOG41067QW Transcriptional regulator A0U91_05695 ENOG4107QRT dEAD DEAH box helicase A0U91_05720 ENOG4105CHR reductase A0U91_05755 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) A0U91_05770 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) A0U91_05775 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A0U91_05780 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A0U91_05790 ENOG4105BZN citrate synthase A0U91_05800 ENOG4105CFF transcriptional regulator A0U91_05830 ENOG4105D7T ABC transporter A0U91_05835 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) A0U91_05840 ENOG4105E8V Alpha Beta Hydrolase Fold protein A0U91_05850 ENOG4105K63 Thioredoxin A0U91_05870 ENOG4105C2M dna polymerase I A0U91_05885 ENOG4105CIH Imidazole acetol-phosphate transaminase A0U91_05920 ENOG4105CQB FAD linked oxidase domain protein A0U91_05935 ENOG4107TB6 phosphoglycerate mutase A0U91_05940 ENOG4105C5T Phosphoribosyl pyrophosphate synthase A0U91_05985 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) A0U91_05995 ENOG4108UN4 phage SPO1 DNA polymerase-related protein A0U91_06000 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division A0U91_06035 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A0U91_06040 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) A0U91_06060 ENOG410901P UPF0249 protein A0U91_06080 ENOG4105DHP deoxycytidine triphosphate deaminase A0U91_06100 ENOG4107QR9 Iron-sulfur cluster binding protein A0U91_06105 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) A0U91_06115 ENOG4105C7K acetolactate synthase A0U91_06130 ENOG4105E2D ec 3.2.1.52 A0U91_06150 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) A0U91_06155 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) A0U91_06160 ENOG4106N3A copper homeostasis protein cutc A0U91_06170 ENOG4105EHZ conserved protein UCP016719 A0U91_06175 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate A0U91_06180 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) A0U91_06195 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) A0U91_06200 ENOG4105C3G gtp-binding protein A0U91_06205 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) A0U91_06220 ENOG4105C9M aspartyl-trna synthetase A0U91_06245 ENOG4105C88 aminopeptidase A0U91_06260 ENOG4108JPW Aminotransferase A0U91_06285 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) A0U91_06290 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A0U91_06300 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) A0U91_06340 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) A0U91_06345 ENOG4105DXN mazG family A0U91_06350 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase A0U91_06355 ENOG4105F6U Short-chain dehydrogenase reductase Sdr A0U91_06360 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family A0U91_06365 ENOG4105C37 (CBS) domain A0U91_06385 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) A0U91_06390 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) A0U91_06400 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) A0U91_06405 ENOG4105BZU Histidine kinase A0U91_06410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A0U91_06420 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis A0U91_06425 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) A0U91_06440 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) A0U91_06445 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) A0U91_06480 ENOG41090R7 Ferric uptake A0U91_06490 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) A0U91_06495 ENOG4108WRK Transcriptional regulator A0U91_06505 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit A0U91_06510 ENOG4105C38 Glycyl-tRNA synthetase beta subunit A0U91_06515 ENOG4108Z7R Chaperone CsaA A0U91_06525 ENOG4105DC1 bifunctional purine biosynthesis protein purh A0U91_06530 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) A0U91_06535 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP A0U91_06540 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) A0U91_06545 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) A0U91_06550 ENOG4105CFG Acts as a chaperone (By similarity) A0U91_06555 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ A0U91_06560 ENOG4105E3W Two component transcriptional regulator (Winged helix family A0U91_06575 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) A0U91_06585 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein A0U91_06595 ENOG4108UJU UPF0301 protein A0U91_06600 ENOG4105CSR polyphosphate kinase 2 A0U91_06615 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) A0U91_06620 ENOG4105DZ1 carboxypeptidase A0U91_06625 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) A0U91_06640 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) A0U91_06660 ENOG4106HMZ Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) A0U91_06665 ENOG4105EIE fructose-bisphosphate aldolase A0U91_06690 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase A0U91_06695 ENOG4105D48 metallophosphoesterase A0U91_06705 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) A0U91_06715 ENOG4107SFH ImpB mucB samB family A0U91_06735 ENOG4108SHN Glycosyl transferase, family 2 A0U91_06760 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) A0U91_06765 ENOG4108FN7 Aldo keto reductase A0U91_06770 ENOG41062IR nudix hydrolase A0U91_06780 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) A0U91_06830 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) A0U91_06840 ENOG4108V1U phospholipid-binding protein A0U91_06850 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) A0U91_06855 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) A0U91_06860 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) A0U91_06870 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) A0U91_06890 ENOG4105C5H ABC transporter A0U91_06900 ENOG4105F0N pyrophosphate phospho-hydrolase A0U91_06910 ENOG4108YYC ycei family A0U91_06920 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) A0U91_06925 ENOG4105D3R alkyl hydroperoxide reductase A0U91_06930 ENOG4105C5Q Transcriptional regulator A0U91_06960 ENOG4105FBD synthase A0U91_06965 ENOG4105FE1 phytoene synthase A0U91_06990 ENOG4107TJ9 Cytochrome A0U91_07010 ENOG4105Y49 secretion protein, HlyD family A0U91_07020 ENOG410834F Transcriptional regulator A0U91_07035 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A0U91_07050 ENOG4108ZZ3 UPF0260 protein A0U91_07080 ENOG4108R4U Hnh endonuclease A0U91_07100 ENOG4105E7D Protein of unknown function (DUF3375) A0U91_07120 ENOG4108UQY Iron-storage protein A0U91_07125 ENOG4105KUZ arsenate reductase A0U91_07135 ENOG4105J12 Multidrug resistance protein mdtN A0U91_07140 ENOG4108MI0 Resistance protein A0U91_07155 ENOG4105EM2 membrane A0U91_07165 ENOG4108R3E Dna-3-methyladenine glycosylase i A0U91_07180 ENOG4105KVH Transcriptional regulator A0U91_07195 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) A0U91_07205 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) A0U91_07215 ENOG4105CNM Receptor A0U91_07220 ENOG4105CQ0 ABC transporter A0U91_07225 ENOG4105C59 p-type ATPase A0U91_07235 ENOG4105VPX protein, conserved in bacteria A0U91_07250 ENOG4105E3B Multicopper oxidase A0U91_07260 ENOG4105E1J oxidoreductase A0U91_07275 ENOG4105CSH Transporter A0U91_07280 ENOG4107RNH Outer membrane receptor FepA A0U91_07290 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) A0U91_07295 ENOG4105CKK Glycosyl transferase, family 2 A0U91_07320 ENOG4107PQ6 Inherit from NOG: atp synthase A0U91_07325 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) A0U91_07330 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A0U91_07335 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) A0U91_07340 ENOG4108UYE Lactoylglutathione lyase A0U91_07365 ENOG4108UJD 30S ribosomal protein S9 A0U91_07370 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) A0U91_07385 ENOG4108UTW Plays a role in the regulation of phosphate uptake A0U91_07390 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) A0U91_07395 ENOG4105E2Z phosphate ABC transporter (Permease A0U91_07400 ENOG4105C8U phosphate abc transporter A0U91_07405 ENOG4105C01 Dihydroxy-acid dehydratase A0U91_07410 ENOG4105CIH Imidazole acetol-phosphate transaminase A0U91_07415 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A0U91_07420 ENOG4105EXC Acyl-transferase A0U91_07430 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein A0U91_07450 ENOG4105D1F ATP-binding protein A0U91_07465 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) A0U91_07485 ENOG4107GFK fumarate A0U91_07495 ENOG4105MWK D-amino acid dehydrogenase, small subunit A0U91_07500 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A0U91_07510 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) A0U91_07530 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) A0U91_07550 ENOG4105EJC lysr family transcriptional regulator A0U91_07555 ENOG4105E5Q amino acid AbC transporter A0U91_07565 ENOG4107QM5 aconitate hydratase A0U91_07570 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) A0U91_07575 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) A0U91_07580 ENOG4105CPC Aldo Keto reductase A0U91_07610 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) A0U91_07615 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein A0U91_07620 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A0U91_07625 ENOG4105CHR reductase A0U91_07630 ENOG4105C54 Major Facilitator superfamily A0U91_07635 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) A0U91_07645 ENOG4107RNH Outer membrane receptor FepA A0U91_07650 ENOG4108JJ7 ABC transporter A0U91_07655 ENOG4105CSM endonuclease III A0U91_07660 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) A0U91_07695 ENOG4105TXM Domain of unknown function (DUF3576) A0U91_07700 ENOG4105C8T Leucyl-tRNA synthetase A0U91_07715 ENOG4105DFP Integrase A0U91_07800 ENOG4105CAR Terminase, large subunit A0U91_07920 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A0U91_07940 ENOG41080HT Transcriptional regulator, arsr family A0U91_07945 ENOG4105D3R alkyl hydroperoxide reductase A0U91_07960 ENOG4108JJ9 ABC, transporter A0U91_07965 ENOG4108JJ8 (ABC) transporter A0U91_07970 ENOG4105C4M (Ubiquinol oxidase) subunit I A0U91_07975 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A0U91_07995 ENOG4108XM1 transcriptional regulator AsnC family A0U91_08005 ENOG4107QPD alcohol dehydrogenase A0U91_08015 ENOG4108NIW Leucine export protein LeuE A0U91_08035 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) A0U91_08045 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) A0U91_08050 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) A0U91_08055 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) A0U91_08060 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) A0U91_08065 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) A0U91_08095 ENOG4107R1I NAD-dependent malic enzyme A0U91_08105 ENOG4108RHM integral membrane protein A0U91_08110 ENOG4105CHR reductase A0U91_08125 ENOG4105DP0 ferredoxin-NADP reductase A0U91_08130 ENOG4105DC8 reductase A0U91_08135 ENOG4105CD3 dihydroorotase A0U91_08140 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB A0U91_08150 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A0U91_08160 ENOG4105ESV Glycosyl transferase, family 4 A0U91_08190 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) A0U91_08195 ENOG4105CCU oxidase (Subunit III) A0U91_08210 ENOG4105HFZ Membrane A0U91_08245 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) A0U91_08260 ENOG4105II7 pyrroline-5-carboxylate reductase A0U91_08280 ENOG4105K70 DNA-binding protein A0U91_08285 ENOG4106IQQ A0U91_08300 ENOG4107QRS glycosyltransferase group 2 family protein A0U91_08315 ENOG4105ECC imidazole-glycerol-phosphate dehydratase A0U91_08330 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) A0U91_08335 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase A0U91_08340 ENOG4105K59 histidine triad (HIT) protein A0U91_08345 ENOG41069NU Nitroreductase A0U91_08355 ENOG4105M0C cytoplasmic protein A0U91_08360 ENOG41067RQ csbd family A0U91_08370 ENOG4105FA0 parb-like partition protein A0U91_08375 ENOG4107QJE Chromosome Partitioning Protein A0U91_08380 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) A0U91_08390 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) A0U91_08395 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A0U91_08415 ENOG4108URH decarboxylase A0U91_08430 ENOG4108YXA Membrane A0U91_08435 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 A0U91_08440 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) A0U91_08445 ENOG4108UHJ MAF-like protein A0U91_08460 ENOG4105C2C drug resistance transporter, Bcr CflA A0U91_08465 ENOG4105CI2 imidazolone-5-propionate hydrolase A0U91_08475 ENOG4105W49 UPF0434 protein A0U91_08480 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) A0U91_08485 ENOG4105K63 Thioredoxin A0U91_08505 ENOG4105C26 Dehydrogenase A0U91_08510 ENOG4105EGI Transcriptional regulator A0U91_08530 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) A0U91_08550 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A0U91_08565 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) A0U91_08590 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A0U91_08595 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) A0U91_08620 ENOG4108Z7F N-acetyltransferase A0U91_08635 ENOG4105BZA Phosphoglycerate kinase A0U91_08645 ENOG4105CV1 Transketolase (EC 2.2.1.1) A0U91_08655 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A0U91_08680 ENOG4105F4R Transcriptional regulator mode A0U91_08685 ENOG4105DJ9 glucan biosynthesis protein A0U91_08690 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) A0U91_08695 ENOG4105CE4 GlcNAc 6-P deacetylase A0U91_08715 ENOG4107QMP dna polymerase iii subunits gamma and tau A0U91_08720 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) A0U91_08725 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) A0U91_08730 ENOG4105EWI Short-chain dehydrogenase reductase Sdr A0U91_08745 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase A0U91_08750 ENOG4105CAT Cytidine monophosphate kinase A0U91_08755 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) A0U91_08765 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) A0U91_08770 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) A0U91_08775 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) A0U91_08780 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) A0U91_08785 ENOG4108JQC penicillin-binding protein 1A A0U91_08790 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) A0U91_08825 ENOG4105XYF acetyltransferase A0U91_08830 ENOG4105ENJ RND efflux system, outer membrane lipoprotein A0U91_08840 ENOG4105C1P efflux transporter, rnd family, mfp subunit A0U91_08845 ENOG4107QNK )-transporter A0U91_08850 ENOG4105CNI cell division protein FtsW A0U91_08855 ENOG4105CJN penicillin-binding protein A0U91_08875 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) A0U91_08880 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) A0U91_08885 ENOG4105C2C drug resistance transporter, Bcr CflA A0U91_08895 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) A0U91_08900 ENOG4105DSW Fusaric acid resistance protein A0U91_08910 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase A0U91_08935 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) A0U91_08945 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving A0U91_08950 ENOG4105CDY transcriptional regulatory protein A0U91_08955 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) A0U91_08960 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) A0U91_08975 ENOG4105E02 MotA TolQ exbB proton channel A0U91_08980 ENOG4105M8F Biopolymer transport protein exbD tolR A0U91_08990 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) A0U91_09000 ENOG4105KCK Peptidoglycan-associated lipoprotein A0U91_09010 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) A0U91_09030 ENOG4105DWF phosphomethylpyrimidine kinase A0U91_09040 ENOG4108E87 P-loop hydrolase UPF0079 A0U91_09055 ENOG4105K63 Thioredoxin A0U91_09080 ENOG4105C8N cysteinyl-tRNA synthetase A0U91_09090 ENOG4105DHZ alpha beta A0U91_09100 ENOG4105C3J Cysteine desulfurase A0U91_09140 ENOG4108RT7 Glycosyl transferase, family 2 A0U91_09185 ENOG4105D1U peptidase U62 modulator of DNA gyrase A0U91_09190 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) A0U91_09205 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters A0U91_09215 ENOG4108UUM single-stranded DNA-binding protein A0U91_09220 ENOG4106H78 methyltransferase A0U91_09225 ENOG4105FE9 pseudouridine synthase A0U91_09230 ENOG4108Z86 Glutamine amidotransferase A0U91_09235 ENOG4108Z6B deaminase A0U91_09260 ENOG4105DS0 Transcriptional regulator, Crp Fnr family A0U91_09270 ENOG4105D4P Coproporphyrinogen iii oxidase A0U91_09280 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase A0U91_09285 ENOG4105TPV A0U91_09290 ENOG4105C10 Electron transfer flavoprotein A0U91_09300 ENOG4105ENJ RND efflux system, outer membrane lipoprotein A0U91_09350 ENOG4105E39 Enoyl-CoA hydratase A0U91_09355 ENOG4105CSP Major Facilitator Superfamily A0U91_09375 ENOG4105ETT transcriptional Regulator, LysR family A0U91_09380 ENOG4105CBG Sulfatase A0U91_09400 ENOG4105D3R alkyl hydroperoxide reductase A0U91_09420 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A0U91_09440 ENOG4107QK9 Beta-lactamase A0U91_09445 ENOG4105MWK D-amino acid dehydrogenase, small subunit A0U91_09455 ENOG4107S1E Beta-lactamase A0U91_09470 ENOG4108IU3 tonb-dependent siderophore receptor A0U91_09485 ENOG4105EZR dyp-type peroxidase family protein A0U91_09490 ENOG4107E2E PKHD-type hydroxylase A0U91_09525 ENOG41065SU Two-component system sensor kinase A0U91_09530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A0U91_09555 ENOG4105KG3 cytidine deaminase A0U91_09570 ENOG4105D9N nucleoside A0U91_09580 ENOG4105F1S paraquat-inducible protein a A0U91_09585 ENOG4105DY2 Paraquat-inducible protein b A0U91_09595 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase A0U91_09600 ENOG4105E96 Colicin v production protein A0U91_09610 ENOG4105EAM Na Pi-cotransporter A0U91_09615 ENOG4105C3R Methionine synthase A0U91_09660 ENOG4105DY2 Paraquat-inducible protein b A0U91_09665 ENOG4105DHJ ABC, transporter A0U91_09675 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) A0U91_09680 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) A0U91_09685 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) A0U91_09700 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A0U91_09710 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) A0U91_09720 ENOG4105CR8 Transcriptional regulator A0U91_09730 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) A0U91_09735 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) A0U91_09740 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) A0U91_09745 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) A0U91_09750 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor A0U91_09770 ENOG4105J7D transcriptional regulator A0U91_09795 ENOG4105XRQ Xanthine dehydrogenase accessory factor A0U91_09805 ENOG4105C5X domain protein A0U91_09870 ENOG4105CUB amino acid A0U91_09875 ENOG4105D05 Receptor A0U91_09880 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein A0U91_09915 ENOG4105C2I pirin domain protein A0U91_09925 ENOG4105CS1 NAD(P)H quinone oxidoreductase A0U91_09930 ENOG4108VBZ doxx family A0U91_09935 ENOG4105D7W serine acetyltransferase A0U91_09940 ENOG4105ESN nucleotide-binding protein A0U91_09945 ENOG4105C9B Cysteine desulfurase A0U91_09960 ENOG4105CYM Glutathione S-transferase A0U91_09970 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) A0U91_09995 ENOG4105C44 Serine transporter A0U91_10040 ENOG4108I5C dEAD DEAH box helicase A0U91_10045 ENOG4105C0D helicase A0U91_10070 ENOG4105C59 p-type ATPase A0U91_10075 ENOG4105CMQ Chloride channel A0U91_10110 ENOG4105EEQ Na H antiporter A0U91_10175 ENOG4105DGW oligopeptidase A A0U91_10200 ENOG4105CSA Coproporphyrinogen iii oxidase A0U91_10205 ENOG4105DFH Transport of potassium into the cell (By similarity) A0U91_10210 ENOG4105DFA alanine racemase domain protein A0U91_10215 ENOG4108JA1 polyketide synthase A0U91_10220 ENOG4108YZN class I peptide chain release factor A0U91_10230 ENOG4105CXG d-lactate dehydrogenase A0U91_10270 ENOG4105DQF Hydrolase A0U91_10275 ENOG4108J5G 6-phosphogluconate dehydrogenase A0U91_10280 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) A0U91_10300 ENOG4105CIH Imidazole acetol-phosphate transaminase A0U91_10330 ENOG4105KK4 UPF0060 membrane protein A0U91_10370 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) A0U91_10380 ENOG4108V0P LemA family A0U91_10395 ENOG4105D05 Receptor A0U91_10400 ENOG4105DAA L-lactate A0U91_10405 ENOG4105E4C Lytic transglycosylase catalytic A0U91_10430 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) A0U91_10465 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) A0U91_10490 ENOG4105MYN Zinc uptake regulation protein A0U91_10500 ENOG4105DIK (ABC) transporter A0U91_10515 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase A0U91_10540 ENOG4107ZSV Receptor A0U91_10550 ENOG4105DSW Fusaric acid resistance protein A0U91_10580 ENOG4105F27 Major Facilitator A0U91_10610 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase A0U91_10615 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) A0U91_10630 ENOG4105D64 Mechanosensitive ion channel A0U91_10650 ENOG4105DZ2 Transcriptional regulator A0U91_10665 ENOG4105EQ2 LysR family Transcriptional regulator A0U91_10690 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase A0U91_10740 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) A0U91_10745 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) A0U91_10755 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase A0U91_10780 ENOG4105CVP deoxyribo-dipyrimidine photolyase A0U91_10790 ENOG4105E0X reductase A0U91_10820 ENOG4105C02 permease A0U91_10900 ENOG4108ZGC gaf domain protein A0U91_10955 ENOG41082BM Transcriptional regulator, arsr family A0U91_10960 ENOG4105C1J atp-dependent rna helicase A0U91_11055 ENOG4105ES4 Nitrilase A0U91_11080 ENOG4105C72 UPF0176 protein A0U91_11100 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A0U91_11250 ENOG4105QNJ serralysin (EC 3.4.24.40) A0U91_11285 ENOG4105EEQ Na H antiporter A0U91_11310 ENOG4105E0K tonB-dependent siderophore receptor A0U91_11345 ENOG4105K78 MarR family Transcriptional regulator A0U91_11355 ENOG4105KPV Transcriptional regulator A0U91_11360 ENOG4105CJ3 phosphate transporter A0U91_11365 ENOG4105C26 Dehydrogenase A0U91_11370 ENOG4105CEP NADH dehydrogenase A0U91_11400 ENOG4105CSW GntR family transcriptional regulator A0U91_11410 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase A0U91_11415 ENOG4105EMU Dehydrogenase A0U91_11460 ENOG4105CYX Short-chain dehydrogenase reductase Sdr A0U91_11470 ENOG4105EXC Acyl-transferase A0U91_11485 ENOG4105FYV Amp nucleosidase A0U91_11490 ENOG4105ENA helicase A0U91_11530 ENOG4105C9K Endothelin-converting enzyme 1 A0U91_11540 ENOG4105DZG Dehydrogenase A0U91_11550 ENOG4108DN8 FAD dependent oxidoreductase A0U91_11560 ENOG4105CSH Transporter A0U91_11565 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase A0U91_11585 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C A0U91_11600 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) A0U91_11630 ENOG4108MP6 LysR family Transcriptional regulator A0U91_11635 ENOG4105C0A alcohol dehydrogenase A0U91_11645 ENOG4105C26 Dehydrogenase A0U91_11660 ENOG4105CGK Exodeoxyribonuclease III A0U91_11665 ENOG4108YX9 iron--sulfur cluster insertion protein erpA A0U91_11670 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein A0U91_11675 ENOG4105C75 arginyL-tRNA synthetase A0U91_11685 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) A0U91_11695 ENOG41081BE Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) A0U91_11705 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) A0U91_11710 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) A0U91_11720 ENOG4105XJC Two component transcriptional regulator (Winged helix family A0U91_11760 ENOG4105CEY Amp-dependent synthetase and ligase A0U91_11800 ENOG4105CM2 brancheD-chain amino acid aminotransferase A0U91_11810 ENOG4105CNG UPF0061 protein A0U91_11815 ENOG4105E0A ABC, transporter A0U91_11820 ENOG4105EHG Permease protein A0U91_11845 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A0U91_11855 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) A0U91_11860 ENOG4105CBT Fructose-1,6-bisphosphatase A0U91_11865 ENOG4105D6E homoserine dehydrogenase A0U91_11870 ENOG4105CHM Aminotransferase A0U91_11880 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A0U91_11900 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E A0U91_11905 ENOG4105Z85 coenzyme PQQ synthesis A0U91_11910 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) A0U91_11915 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) A0U91_11940 ENOG4105X1Q TOBE domain protein A0U91_11970 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) A0U91_11975 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) A0U91_11985 ENOG4105C03 ribonuclease A0U91_11990 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase A0U91_12070 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) A0U91_12080 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A0U91_12090 ENOG4108XEG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A0U91_12100 ENOG4106VK6 Flagellar motor protein A0U91_12115 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) A0U91_12140 ENOG4105C22 threonyL-tRNA synthetase A0U91_12145 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) A0U91_12175 ENOG4105F27 Major Facilitator A0U91_12180 ENOG4105C5H ABC transporter A0U91_12185 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) A0U91_12190 ENOG4105EPH radical SAM domain protein A0U91_12215 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) A0U91_12220 ENOG4105CHM Aminotransferase A0U91_12225 ENOG4105CHM Aminotransferase A0U91_12245 ENOG4108C33 Resolvase A0U91_12255 ENOG4105M4H endoribonuclease L-psp A0U91_12260 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) A0U91_12265 ENOG4105CPC Aldo Keto reductase A0U91_12310 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) A0U91_12315 ENOG4105C0B DNA polymerase III (alpha subunit) A0U91_12325 ENOG4105YAZ 4-amino-4-deoxychorismate lyase A0U91_12340 ENOG4105CE9 30S ribosomal protein S2 A0U91_12345 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) A0U91_12350 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) A0U91_12355 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A0U91_12365 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate A0U91_12370 ENOG4105D52 delta-aminolevulinic acid dehydratase A0U91_12375 ENOG4105CUB amino acid A0U91_12380 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) A0U91_12390 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) A0U91_12415 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA A0U91_12425 ENOG4105EAC phosphoserine phosphatase A0U91_12430 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) A0U91_12435 ENOG4105C7K acetolactate synthase A0U91_12440 ENOG4108ZP8 Acetolactate synthase small subunit A0U91_12445 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase A0U91_12455 ENOG4108RWI nicotinamidase A0U91_12460 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) A0U91_12475 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase A0U91_12500 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) A0U91_12505 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) A0U91_12515 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) A0U91_12520 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane A0U91_12525 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) A0U91_12540 ENOG4108UFP Essential cell division protein (By similarity) A0U91_12545 ENOG4105CPF Cell wall formation (By similarity) A0U91_12550 ENOG4105D4A Cell wall formation (By similarity) A0U91_12555 ENOG4105DFU Cell wall formation (By similarity) A0U91_12560 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) A0U91_12570 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) A0U91_12575 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) A0U91_12585 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) A0U91_12600 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) A0U91_12605 ENOG4107YUR Cell division protein mraZ A0U91_12625 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase A0U91_12630 ENOG4105Y2X UPF0335 protein A0U91_12640 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) A0U91_12645 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control A0U91_12655 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) A0U91_12685 ENOG4108R6W Transcriptional regulator, ARAC family A0U91_12690 ENOG4105CPD ethanolamine ammonia-lyase A0U91_12695 ENOG4107FQ9 ethanolamine ammonia-lyase A0U91_12720 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) A0U91_12725 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) A0U91_12750 ENOG4107QNK )-transporter A0U91_12780 ENOG4105Y49 secretion protein, HlyD family A0U91_12810 ENOG4108RIR Molybdenum cofactor biosynthesis protein A0U91_12825 ENOG4105EUJ GTP cyclohydrolase i A0U91_12830 ENOG4105NWN ApaG protein A0U91_12840 ENOG4105M6F mutator MutT protein A0U91_12875 ENOG4105C25 Primosomal protein n' A0U91_12880 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A0U91_12900 ENOG4105BZU Histidine kinase A0U91_12955 ENOG4108YZA Nitrogen regulatory protein pii A0U91_12960 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family A0U91_12965 ENOG4105D7W serine acetyltransferase A0U91_12980 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) A0U91_12985 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) A0U91_13000 ENOG4105DVT helicase A0U91_13005 ENOG4105ECY inositol monophosphatase A0U91_13010 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) A0U91_13045 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase A0U91_13055 ENOG4105HSS phospholipase C A0U91_13080 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) A0U91_13085 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) A0U91_13110 ENOG4107TAE Glycosyl transferase (Group 1 A0U91_13125 ENOG4105K64 Glycosyl transferase, family 2 A0U91_13130 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) A0U91_13135 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) A0U91_13160 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A0U91_13165 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) A0U91_13170 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) A0U91_13180 ENOG4108RVA ribokinase A0U91_13190 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit A0U91_13195 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A0U91_13215 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) A0U91_13225 ENOG4105CHH sulfate transporter A0U91_13230 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) A0U91_13235 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase A0U91_13240 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) A0U91_13245 ENOG4105CAQ asparagine synthetase A0U91_13250 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) A0U91_13275 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) A0U91_13280 ENOG4105C6Z Gluconate A0U91_13285 ENOG4105C0R drug resistance transporter emrb qaca subfamily A0U91_13290 ENOG4105D1K glutamate--cysteine ligase A0U91_13315 ENOG4105D1H recombination factor protein RarA A0U91_13320 ENOG4105EI2 Pseudouridine synthase A0U91_13345 ENOG4105K5M 30s ribosomal protein S16 A0U91_13350 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) A0U91_13355 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) A0U91_13360 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) A0U91_13370 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A0U91_13375 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A0U91_13385 ENOG4105K5G 30S ribosomal protein S21 A0U91_13390 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A0U91_13405 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A0U91_13410 ENOG4105E0F Histidine kinase A0U91_13425 ENOG41082R8 50S ribosomal protein l32 A0U91_13430 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) A0U91_13435 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) A0U91_13440 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) A0U91_13465 ENOG4108UN4 phage SPO1 DNA polymerase-related protein A0U91_13470 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) A0U91_13485 ENOG4105GZI Transcriptional regulator A0U91_13490 ENOG4105C3M thioredoxin reductase A0U91_13495 ENOG4105F7P transcriptional regulator AsnC family A0U91_13520 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A0U91_13525 ENOG4105BZ9 Cytochrome C oxidase, subunit I A0U91_13530 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) A0U91_13545 ENOG4105CMS peptidase U62, modulator of DNA gyrase A0U91_13555 ENOG4105D98 threonine synthase A0U91_13565 ENOG4105CTD carboxy-peptidase A0U91_13575 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) A0U91_13580 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) A0U91_13590 ENOG4108JJ7 ABC transporter A0U91_13600 ENOG4105KDC 50s ribosomal protein l28 A0U91_13605 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) A0U91_13630 ENOG41066T0 asmA family A0U91_13655 ENOG4105C3K feS assembly ATPase SufC A0U91_13660 ENOG4105JRK feS assembly protein SufD A0U91_13665 ENOG4105C9B Cysteine desulfurase A0U91_13675 ENOG4105VG1 fes assembly suf system protein A0U91_13680 ENOG4108Z4V iron-sulfur cluster assembly A0U91_13685 ENOG4107QS4 23S rRNA A0U91_13690 ENOG4105C1J atp-dependent rna helicase A0U91_13700 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) A0U91_13710 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation A0U91_13715 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A0U91_13720 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) A0U91_13725 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) A0U91_13740 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain A0U91_13745 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A0U91_13750 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain A0U91_13755 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A0U91_13765 ENOG4107QIZ NADH dehydrogenase A0U91_13775 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) A0U91_13780 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A0U91_13785 ENOG4105DF2 NADH dehydrogenase subunit j A0U91_13790 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A0U91_13795 ENOG4105D65 subunit l A0U91_13800 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A0U91_13805 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase A0U91_13810 ENOG4107QNB Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) A0U91_13820 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) A0U91_13830 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) A0U91_13850 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) A0U91_13855 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) A0U91_13860 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) A0U91_13865 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) A0U91_13905 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A0U91_13915 ENOG4107RCI amp-dependent synthetase and ligase A0U91_14040 ENOG4106F1P AAA ATPase, central domain protein A0U91_14125 ENOG4105CHC glucokinase (EC 2.7.1.2) A0U91_14140 ENOG4105R1U AraC Family Transcriptional Regulator A0U91_14155 ENOG4105Y49 secretion protein, HlyD family A0U91_14175 ENOG4105EXG Transcriptional regulator A0U91_14180 ENOG4105EE1 crotonyl-CoA reductase A0U91_14185 ENOG4105EQ0 Major Facilitator superfamily A0U91_14190 ENOG4105CC0 LysR family Transcriptional regulator A0U91_14235 ENOG4108ZNX Heat shock protein A0U91_14245 ENOG4105C0R drug resistance transporter emrb qaca subfamily A0U91_14250 ENOG4105D3W isochorismatase A0U91_14255 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) A0U91_14290 ENOG4105CN1 protease A0U91_14320 ENOG4105EQ2 LysR family Transcriptional regulator A0U91_14335 ENOG4105ENJ RND efflux system, outer membrane lipoprotein A0U91_14350 ENOG4108VAU general secretion pathway protein G A0U91_14355 ENOG4105FTC Lytic transglycosylase catalytic A0U91_14365 ENOG4105GVR general secretion pathway protein D A0U91_14380 ENOG4107QHF type ii secretion system protein e A0U91_14385 ENOG4105D7Q type ii secretion system A0U91_14435 ENOG4107R4I Periplasmic binding protein A0U91_14440 ENOG4105EHG Permease protein A0U91_14445 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) A0U91_14455 ENOG4108YNN Heme oxygenase A0U91_14460 ENOG4107ENK receptor A0U91_14470 ENOG4108ZZF transport protein (ExbD) A0U91_14490 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) A0U91_14505 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) A0U91_14725 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis A0U91_14770 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) A0U91_14785 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 A0U91_14980 ENOG4105W00 Flagellar hook capping protein A0U91_14995 ENOG4107RD7 Flagellar Motor Protein, MotA A0U91_15000 ENOG4105ER2 Ompa motb domain protein A0U91_15015 ENOG4108JIR Flagellum-specific ATP synthase A0U91_15045 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) A0U91_15060 ENOG4105D7B Flagellar biosynthesis protein flha A0U91_15070 ENOG4105CN7 Flagellar biosynthetic protein FliP A0U91_15080 ENOG4105DD5 Flagellar motor switch protein A0U91_15090 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) A0U91_15095 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) A0U91_15110 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) A0U91_15120 ENOG4105CGA flagellar basal-body rod protein FlgG A0U91_15125 ENOG4108JQA flagellar A0U91_15160 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) A0U91_15165 ENOG4107W75 Flagellin A0U91_15195 ENOG4105VS8 Flagellar biosynthetic protein fliq A0U91_15205 ENOG4105D00 flagellar biosynthetic protein flhB A0U91_15210 ENOG4105BZE flagellar hook protein, FlgE A0U91_15215 ENOG4105UT3 Methyl-accepting chemotaxis A0U91_15225 ENOG4105Y2X UPF0335 protein A0U91_15250 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) A0U91_15290 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) A0U91_15370 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) A0U91_15385 ENOG4107RZZ dna polymerase iii epsilon subunit A0U91_15415 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) A0U91_15435 ENOG4107U53 septum site-determining protein minD A0U91_15515 ENOG4107QXV Phosphate transporter A0U91_15590 ENOG4105C4R Atp-dependent dna helicase A0U91_15595 ENOG4105C0B DNA polymerase III (alpha subunit) A0U91_15600 ENOG4105C0B DNA polymerase III (alpha subunit) A0U91_15605 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A0U91_15690 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) A0U91_15915 ENOG41060M0 Crispr-associated protein, cse4 family A0U91_15920 ENOG4108VWQ crispr-associated protein A0U91_15960 ENOG4107QYX exodeoxyribonuclease v alpha A0U91_15960 ENOG4107QYX exodeoxyribonuclease v alpha A0U91_16020 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) A0U91_16120 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) A0U91_16270 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) A0U91_16395 ENOG4105CZX twitching motility protein A0U91_16440 ENOG4107QHF type ii secretion system protein e A0U91_16485 ENOG4108UUM single-stranded DNA-binding protein A0U91_16490 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A0U91_16530 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) A0U91_16555 ENOG4108VYJ response regulator receiver protein A0U91_16565 ENOG4108V3W Chemotaxis protein, CheW A0U91_16570 ENOG4105BZU Histidine kinase A0U91_16575 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) A0U91_16580 ENOG4108VYJ response regulator receiver protein A0U91_16625 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) A0U91_16645 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) A0U91_16675 ENOG4105NI8 Cytosine-specific methyltransferase A0U91_16740 ENOG4105D7V transposase A0U91_16775 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A0U91_16780 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A0U91_16895 ENOG4105ENG CRISPR-associated protein, Csy1 family A0U91_16905 ENOG4105M6W Crispr-associated protein, Csy3 family A0U91_16960 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs A0U91_17005 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)