locus-tag	class	description
A0U91_00060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A0U91_00080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A0U91_00120	COG0583	DNA-binding transcription factor activity
A0U91_00130	COG0431	NADPH-dependent FMN reductase
A0U91_00140	COG1584	GPR1 FUN34 yaaH family protein
A0U91_00330	COG0842	Transport permease protein
A0U91_00335	COG0842	Transport permease protein
A0U91_00335	COG1129	ABC transporter
A0U91_00340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U91_00355	COG0167	dihydroorotate dehydrogenase activity
A0U91_00370	COG0306	phosphate transporter
A0U91_00380	COG2814	Major facilitator Superfamily
A0U91_00410	COG1802	Transcriptional regulator
A0U91_00415	COG0531	amino acid
A0U91_00430	COG0006	proline dipeptidase activity
A0U91_00440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0U91_00455	COG3938	Belongs to the proline racemase family
A0U91_00500	COG0583	DNA-binding transcription factor activity
A0U91_00505	COG1289	transmembrane transporter activity
A0U91_00520	COG0180	Tryptophanyl-tRNA synthetase
A0U91_00535	COG0137	argininosuccinate synthase activity
A0U91_00540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A0U91_00550	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A0U91_00555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A0U91_00560	COG0142	geranyltranstransferase activity
A0U91_00565	COG1722	exodeoxyribonuclease VII activity
A0U91_00570	COG0425	Belongs to the sulfur carrier protein TusA family
A0U91_00575	COG1940	carbohydrate kinase activity
A0U91_00580	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A0U91_00585	COG0248	Ppx GppA phosphatase
A0U91_00630	COG2186	Transcriptional regulator
A0U91_00640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A0U91_00660	COG0402	S-adenosylhomocysteine deaminase activity
A0U91_00665	COG0583	DNA-binding transcription factor activity
A0U91_00670	COG2072	flavoprotein involved in K transport
A0U91_00685	COG2351	hydroxyisourate hydrolase activity
A0U91_00705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A0U91_00725	COG3383	formate dehydrogenase (NAD+) activity
A0U91_00725	COG0243	molybdopterin cofactor binding
A0U91_00730	COG0437	4 iron, 4 sulfur cluster binding
A0U91_00735	COG2864	formate dehydrogenase
A0U91_00750	COG1763	Mo-molybdopterin cofactor biosynthetic process
A0U91_00795	COG0431	NADPH-dependent FMN reductase
A0U91_00820	COG3038	cytochrome b561
A0U91_00895	COG5489	Protein of unknown function (DUF736)
A0U91_00935	COG5489	Protein of unknown function (DUF736)
A0U91_00980	COG4962	Type ii secretion system protein e
A0U91_00985	COG3838	Conjugal transfer protein Trbc
A0U91_00995	COG3451	type IV secretory pathway VirB4
A0U91_01005	COG3846	protein secretion by the type IV secretion system
A0U91_01035	COG3415	Transposase
A0U91_01050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A0U91_01060	COG2972	Histidine kinase
A0U91_01060	COG2205	protein histidine kinase activity
A0U91_01065	COG1032	radical SAM domain protein
A0U91_01070	COG2801	Transposase and inactivated derivatives
A0U91_01070	COG3415	Transposase
A0U91_01090	COG4974	Belongs to the 'phage' integrase family
A0U91_01200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A0U91_01210	COG0302	gtp cyclohydrolase
A0U91_01215	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A0U91_01220	COG0523	cobalamin synthesis protein
A0U91_01265	COG1028	Short-chain dehydrogenase reductase Sdr
A0U91_01270	COG0583	DNA-binding transcription factor activity
A0U91_01290	COG2207	Transcriptional regulator
A0U91_01295	COG0300	oxidoreductase activity
A0U91_01305	COG1028	Short-chain dehydrogenase reductase Sdr
A0U91_01310	COG2226	methyltransferase
A0U91_01330	COG3293	Transposase
A0U91_01355	COG0439	Biotin carboxylase
A0U91_01380	COG4771	TonB-dependent receptor
A0U91_01400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A0U91_01410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A0U91_01460	COG1335	isochorismatase
A0U91_01465	COG0477	Major facilitator Superfamily
A0U91_01480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A0U91_01485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A0U91_01515	COG1464	Belongs to the NlpA lipoprotein family
A0U91_01530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A0U91_01535	COG2011	ABC-type metal ion transport system permease component
A0U91_01565	COG0583	DNA-binding transcription factor activity
A0U91_01575	COG1538	Outer membrane efflux protein
A0U91_01580	COG0577	efflux transmembrane transporter activity
A0U91_01585	COG1136	(ABC) transporter
A0U91_01595	COG2204	response regulator
A0U91_01610	COG0583	DNA-binding transcription factor activity
A0U91_01615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0U91_01655	COG2072	flavoprotein involved in K transport
A0U91_01690	COG4221	oxidoreductase activity
A0U91_01710	COG0438	transferase activity, transferring glycosyl groups
A0U91_01715	COG0438	transferase activity, transferring glycosyl groups
A0U91_01735	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A0U91_01740	COG4251	negative regulation of phosphorylation
A0U91_01765	COG1914	H( )-stimulated, divalent metal cation uptake system
A0U91_01770	COG1321	iron dependent repressor
A0U91_01815	COG0784	Response regulator, receiver
A0U91_01840	COG4988	ABC transporter
A0U91_01845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A0U91_01875	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A0U91_01885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A0U91_01890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A0U91_01895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A0U91_01920	COG0525	valine-tRNA ligase activity
A0U91_01925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0U91_01935	COG4176	ABC-type proline glycine betaine transport system permease component
A0U91_01945	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A0U91_01950	COG2226	methyltransferase
A0U91_01955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A0U91_01960	COG0268	Binds directly to 16S ribosomal RNA
A0U91_01965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A0U91_01970	COG0592	DNA-directed DNA polymerase activity
A0U91_01975	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A0U91_01985	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A0U91_01990	COG0504	CTP synthase activity
A0U91_01995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A0U91_02000	COG0149	triose-phosphate isomerase activity
A0U91_02025	COG0134	indole-3-glycerol-phosphate synthase activity
A0U91_02030	COG0315	cyclic pyranopterin monophosphate synthase activity
A0U91_02035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A0U91_02040	COG0022	dehydrogenase e1 component
A0U91_02040	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0U91_02045	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0U91_02050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0U91_02055	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A0U91_02060	COG2867	negative regulation of translational initiation
A0U91_02070	COG1546	Belongs to the CinA family
A0U91_02075	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A0U91_02085	COG0861	Integral membrane protein TerC family
A0U91_02090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A0U91_02095	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A0U91_02100	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A0U91_02110	COG0047	phosphoribosylformylglycinamidine synthase activity
A0U91_02115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A0U91_02120	COG0271	Belongs to the BolA IbaG family
A0U91_02125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A0U91_02135	COG0792	nuclease activity
A0U91_02160	COG2897	thiosulfate sulfurtransferase activity
A0U91_02165	COG0626	cystathionine gamma-synthase activity
A0U91_02170	COG0606	chelatase, subunit chli
A0U91_02175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A0U91_02190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A0U91_02195	COG0077	Prephenate dehydratase
A0U91_02195	COG1605	Chorismate mutase
A0U91_02200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0U91_02205	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A0U91_02210	COG1278	Cold shock
A0U91_02240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A0U91_02250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A0U91_02255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0U91_02260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A0U91_02280	COG1663	tetraacyldisaccharide 4'-kinase activity
A0U91_02285	COG1519	Transferase
A0U91_02295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A0U91_02305	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A0U91_02310	COG4208	sulfate ABC transporter
A0U91_02315	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A0U91_02330	COG0175	sulfate reduction
A0U91_02340	COG0583	DNA-binding transcription factor activity
A0U91_02345	COG1028	Short-chain dehydrogenase reductase Sdr
A0U91_02355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A0U91_02365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A0U91_02375	COG0579	oxidoreductase
A0U91_02380	COG1764	response to oxidative stress
A0U91_02385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A0U91_02390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A0U91_02395	COG0259	pyridoxamine-phosphate oxidase activity
A0U91_02410	COG0084	hydrolase, TatD family'
A0U91_02425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A0U91_02430	COG1686	Belongs to the peptidase S11 family
A0U91_02445	COG0586	Pfam SNARE associated Golgi protein
A0U91_02455	COG0531	amino acid
A0U91_02460	COG1968	undecaprenyl-diphosphatase activity
A0U91_02465	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A0U91_02480	COG2890	protein-(glutamine-N5) methyltransferase activity
A0U91_02490	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A0U91_02500	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A0U91_02510	COG2070	2-Nitropropane dioxygenase
A0U91_02515	COG0527	aspartate kinase activity
A0U91_02520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A0U91_02525	COG2706	6-phosphogluconolactonase activity
A0U91_02540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A0U91_02545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A0U91_02575	COG0321	lipoyl(octanoyl) transferase activity
A0U91_02620	COG0076	glutamate decarboxylase activity
A0U91_02645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A0U91_02650	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A0U91_02665	COG2022	thiamine diphosphate biosynthetic process
A0U91_02695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A0U91_02710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A0U91_02715	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A0U91_02715	COG4106	trans-aconitate 2-methyltransferase activity
A0U91_02735	COG0314	molybdopterin synthase activity
A0U91_02740	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A0U91_02755	COG0322	excinuclease ABC activity
A0U91_02775	COG0729	surface antigen
A0U91_02785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A0U91_02805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A0U91_02830	COG0287	Prephenate dehydrogenase
A0U91_02830	COG1605	Chorismate mutase
A0U91_02855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A0U91_02860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A0U91_02865	COG0142	geranyltranstransferase activity
A0U91_02875	COG1372	Participates in initiation and elongation during chromosome replication
A0U91_02875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0U91_02880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0U91_02880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A0U91_02890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A0U91_02905	COG1970	mechanosensitive ion channel activity
A0U91_02910	COG0254	rRNA binding
A0U91_02915	COG0071	Belongs to the small heat shock protein (HSP20) family
A0U91_02935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A0U91_02940	COG2003	Belongs to the UPF0758 family
A0U91_02945	COG2003	Belongs to the UPF0758 family
A0U91_02950	COG0210	DNA helicase
A0U91_02955	COG2264	protein methyltransferase activity
A0U91_02960	COG0006	proline dipeptidase activity
A0U91_02965	COG0473	3-isopropylmalate dehydrogenase activity
A0U91_02975	COG2814	Major facilitator Superfamily
A0U91_02985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A0U91_03015	COG0114	fumarate hydratase activity
A0U91_03020	COG0747	negative chemotaxis
A0U91_03035	COG0072	phenylalanine-tRNA ligase activity
A0U91_03035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0U91_03040	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A0U91_03045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A0U91_03050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A0U91_03055	COG0246	Mannitol dehydrogenase
A0U91_03085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A0U91_03090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A0U91_03115	COG2884	Cell division ATP-binding protein ftsE
A0U91_03135	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A0U91_03140	COG3781	membrane
A0U91_03165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A0U91_03170	COG2081	HI0933 family
A0U91_03180	COG0850	regulation of cytokinetic process
A0U91_03185	COG2894	cell division
A0U91_03190	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A0U91_03195	COG1802	Transcriptional regulator
A0U91_03200	COG1132	(ABC) transporter
A0U91_03205	COG1648	precorrin-2 dehydrogenase activity
A0U91_03205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A0U91_03215	COG0656	L-ascorbic acid biosynthetic process
A0U91_03255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A0U91_03260	COG0359	binds to the 23S rRNA
A0U91_03265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A0U91_03270	COG0360	Binds together with S18 to 16S ribosomal RNA
A0U91_03280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A0U91_03285	COG0358	DNA primase activity
A0U91_03315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A0U91_03320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A0U91_03325	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A0U91_03335	COG0793	Belongs to the peptidase S41A family
A0U91_03350	COG2814	Major facilitator Superfamily
A0U91_03360	COG1132	(ABC) transporter
A0U91_03365	COG0617	tRNA 3'-terminal CCA addition
A0U91_03375	COG0714	Associated with various cellular activities
A0U91_03400	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A0U91_03405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A0U91_03415	COG0477	Major facilitator Superfamily
A0U91_03420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U91_03425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A0U91_03435	COG1538	Outer membrane efflux protein
A0U91_03475	COG0203	ribosomal protein L17
A0U91_03480	COG0202	RNA polymerase activity
A0U91_03485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A0U91_03490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A0U91_03495	COG0563	adenylate kinase activity
A0U91_03505	COG0200	Binds to the 23S rRNA
A0U91_03510	COG1841	ribosomal large subunit assembly
A0U91_03515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A0U91_03520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A0U91_03525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A0U91_03530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A0U91_03535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A0U91_03540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A0U91_03545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A0U91_03550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A0U91_03555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A0U91_03560	COG0255	Belongs to the universal ribosomal protein uL29 family
A0U91_03565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A0U91_03570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A0U91_03575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A0U91_03580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A0U91_03585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A0U91_03590	COG0089	rRNA binding
A0U91_03595	COG0088	Forms part of the polypeptide exit tunnel
A0U91_03600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A0U91_03605	COG0051	transcription antitermination factor activity, RNA binding
A0U91_03610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A0U91_03615	COG0049	tRNA binding
A0U91_03620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A0U91_03625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A0U91_03630	COG0085	RNA polymerase activity
A0U91_03635	COG0222	ribosome binding
A0U91_03640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A0U91_03645	COG0081	regulation of translation
A0U91_03650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A0U91_03655	COG1538	Outer membrane efflux protein
A0U91_03670	COG0642	Histidine kinase
A0U91_03675	COG0745	RESPONSE REGULATOR receiver
A0U91_03680	COG1322	Protein conserved in bacteria
A0U91_03690	COG0477	Major facilitator Superfamily
A0U91_03700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A0U91_03735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A0U91_03790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A0U91_03795	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A0U91_03800	COG1138	Cytochrome C-type biogenesis protein
A0U91_03805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A0U91_03820	COG1794	racemase activity, acting on amino acids and derivatives
A0U91_03830	COG1301	dicarboxylic acid transport
A0U91_03855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0U91_03860	COG1289	transmembrane transporter activity
A0U91_03900	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A0U91_03920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A0U91_03930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A0U91_03940	COG0297	glycogen (starch) synthase activity
A0U91_03950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A0U91_03955	COG0237	dephospho-CoA kinase activity
A0U91_03960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A0U91_03975	COG0165	Argininosuccinate lyase
A0U91_03980	COG0019	diaminopimelate decarboxylase activity
A0U91_03990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A0U91_04000	COG0640	Transcriptional regulator
A0U91_04005	COG1902	pentaerythritol trinitrate reductase activity
A0U91_04020	COG1028	Short-chain dehydrogenase reductase Sdr
A0U91_04025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A0U91_04030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A0U91_04030	COG2857	Cytochrome c1
A0U91_04035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A0U91_04040	COG0408	coproporphyrinogen oxidase activity
A0U91_04055	COG1858	cytochrome C peroxidase
A0U91_04060	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A0U91_04075	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A0U91_04095	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A0U91_04110	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A0U91_04115	COG1546	Belongs to the CinA family
A0U91_04115	COG1058	Belongs to the CinA family
A0U91_04125	COG4974	Belongs to the 'phage' integrase family
A0U91_04140	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A0U91_04145	COG2885	chlorophyll binding
A0U91_04145	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A0U91_04155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A0U91_04160	COG0688	phosphatidylethanolamine metabolic process
A0U91_04170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U91_04235	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A0U91_04260	COG0508	dehydrogenase complex catalyzes the overall conversion of
A0U91_04270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A0U91_04275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A0U91_04280	COG0658	competence protein
A0U91_04280	COG2333	competence protein COMEC
A0U91_04285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0U91_04295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A0U91_04300	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A0U91_04310	COG0758	DNA mediated transformation
A0U91_04315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A0U91_04320	COG0557	exoribonuclease II activity
A0U91_04340	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A0U91_04340	COG2885	chlorophyll binding
A0U91_04345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A0U91_04350	COG1959	2 iron, 2 sulfur cluster binding
A0U91_04365	COG0187	DNA topoisomerase II activity
A0U91_04370	COG5006	permease, DMT superfamily
A0U91_04395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A0U91_04400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A0U91_04405	COG0196	riboflavin kinase activity
A0U91_04415	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A0U91_04420	COG0235	Class ii aldolase
A0U91_04425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A0U91_04445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A0U91_04450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A0U91_04460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A0U91_04475	COG1643	Atp-dependent helicase
A0U91_04480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A0U91_04490	COG0656	L-ascorbic acid biosynthetic process
A0U91_04510	COG1294	oxidase, subunit
A0U91_04515	COG1271	oxidase subunit
A0U91_04530	COG4771	TonB-dependent receptor
A0U91_04545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A0U91_04555	COG0009	L-threonylcarbamoyladenylate synthase
A0U91_04590	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A0U91_04615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A0U91_04635	COG0506	proline dehydrogenase activity
A0U91_04635	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A0U91_04635	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A0U91_04655	COG0028	Belongs to the TPP enzyme family
A0U91_04675	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A0U91_04680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A0U91_04720	COG0305	Participates in initiation and elongation during chromosome replication
A0U91_04725	COG2942	2-epimerase
A0U91_04730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A0U91_04730	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A0U91_04740	COG0300	oxidoreductase activity
A0U91_04745	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A0U91_04750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A0U91_04755	COG1671	Belongs to the UPF0178 family
A0U91_04765	COG0586	Pfam SNARE associated Golgi protein
A0U91_04775	COG0517	IMP dehydrogenase activity
A0U91_04775	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A0U91_04790	COG1137	ATPase activity
A0U91_04800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A0U91_04815	COG0242	peptide deformylase activity
A0U91_04820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A0U91_04825	COG0101	tRNA pseudouridine synthase activity
A0U91_04830	COG2070	2-Nitropropane dioxygenase
A0U91_04840	COG2855	membrane
A0U91_04855	COG2171	N-acyltransferase activity
A0U91_04860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A0U91_04865	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A0U91_04870	COG0706	membrane insertase activity
A0U91_04875	COG0594	ribonuclease P activity
A0U91_04880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A0U91_04890	COG0346	lactoylglutathione lyase activity
A0U91_04895	COG3494	Protein of unknown function (DUF1009)
A0U91_04900	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0U91_04905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A0U91_04910	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0U91_04920	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A0U91_04925	COG0750	zinc metalloprotease
A0U91_04930	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A0U91_04940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A0U91_04945	COG0233	cytoplasmic translational termination
A0U91_04950	COG0528	UMP kinase activity
A0U91_04955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A0U91_04960	COG0571	ribonuclease III activity
A0U91_04965	COG0681	Belongs to the peptidase S26 family
A0U91_04970	COG0736	holo-[acyl-carrier-protein] synthase activity
A0U91_04975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A0U91_04980	COG1758	RNA polymerase activity
A0U91_05005	COG0513	Belongs to the DEAD box helicase family
A0U91_05010	COG0778	Nitroreductase
A0U91_05015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A0U91_05015	COG2813	Specifically methylates the guanine in position
A0U91_05025	COG0481	GTPase activity
A0U91_05055	COG4993	Dehydrogenase
A0U91_05075	COG4206	TonB-dependent receptor
A0U91_05100	COG2076	Multidrug Resistance protein
A0U91_05115	COG3104	oligopeptide transport
A0U91_05120	COG0538	isocitrate dehydrogenase activity
A0U91_05140	COG0492	ferredoxin-NADP+ reductase activity
A0U91_05190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A0U91_05195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U91_05215	COG1794	racemase activity, acting on amino acids and derivatives
A0U91_05275	COG4774	siderophore transport
A0U91_05295	COG0469	pyruvate kinase activity
A0U91_05310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A0U91_05335	COG1297	OPT oligopeptide transporter protein
A0U91_05340	COG0463	Glycosyl transferase, family 2
A0U91_05345	COG0463	Glycosyl transferase, family 2
A0U91_05365	COG4774	siderophore transport
A0U91_05395	COG4774	siderophore transport
A0U91_05405	COG1122	ATPase activity
A0U91_05425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A0U91_05445	COG0523	cobalamin synthesis protein
A0U91_05485	COG0523	cobalamin synthesis protein
A0U91_05500	COG0022	dehydrogenase e1 component
A0U91_05505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A0U91_05560	COG0135	phosphoribosylanthranilate isomerase activity
A0U91_05565	COG0284	orotidine-5'-phosphate decarboxylase activity
A0U91_05575	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A0U91_05590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A0U91_05595	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A0U91_05605	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A0U91_05625	COG3145	DNA-N1-methyladenine dioxygenase activity
A0U91_05630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A0U91_05635	COG2353	YceI-like domain
A0U91_05640	COG3620	sequence-specific DNA binding
A0U91_05695	COG1201	RNA secondary structure unwinding
A0U91_05755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A0U91_05770	COG0463	Glycosyl transferase, family 2
A0U91_05775	COG2226	methyltransferase
A0U91_05780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A0U91_05790	COG0372	Belongs to the citrate synthase family
A0U91_05795	COG2079	MmgE PrpD family protein
A0U91_05800	COG1396	sequence-specific DNA binding
A0U91_05800	COG3800	Transcriptional regulator
A0U91_05805	COG2223	nitrite transmembrane transporter activity
A0U91_05830	COG1116	anion transmembrane transporter activity
A0U91_05830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A0U91_05835	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A0U91_05840	COG2267	carboxylic ester hydrolase activity
A0U91_05870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A0U91_05870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A0U91_05885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A0U91_05920	COG0277	FAD linked oxidase domain protein
A0U91_05935	COG0406	alpha-ribazole phosphatase activity
A0U91_05940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A0U91_05985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A0U91_05995	COG1573	uracil-dna glycosylase
A0U91_06000	COG0741	lytic transglycosylase activity
A0U91_06025	COG1253	flavin adenine dinucleotide binding
A0U91_06035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A0U91_06040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A0U91_06060	COG3394	polysaccharide catabolic process
A0U91_06080	COG0717	Belongs to the dCTP deaminase family
A0U91_06100	COG1139	Iron-sulfur cluster binding protein
A0U91_06105	COG0247	lactate metabolic process
A0U91_06130	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A0U91_06150	COG1940	carbohydrate kinase activity
A0U91_06160	COG3142	Participates in the control of copper homeostasis
A0U91_06170	COG3876	Protein conserved in bacteria
A0U91_06175	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A0U91_06180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A0U91_06185	COG0799	negative regulation of ribosome biogenesis
A0U91_06195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A0U91_06200	COG0012	GTP binding
A0U91_06205	COG0193	aminoacyl-tRNA hydrolase activity
A0U91_06210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A0U91_06220	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A0U91_06245	COG2309	aminopeptidase activity
A0U91_06260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A0U91_06285	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A0U91_06290	COG0154	amidase activity
A0U91_06300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A0U91_06340	COG0326	Molecular chaperone. Has ATPase activity
A0U91_06345	COG3956	TIGRFAM MazG family protein
A0U91_06350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A0U91_06355	COG1028	Short-chain dehydrogenase reductase Sdr
A0U91_06360	COG0604	alcohol dehydrogenase
A0U91_06365	COG1253	flavin adenine dinucleotide binding
A0U91_06390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A0U91_06400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A0U91_06410	COG0745	RESPONSE REGULATOR receiver
A0U91_06420	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A0U91_06425	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A0U91_06440	COG0159	tryptophan synthase activity
A0U91_06445	COG0133	tryptophan synthase activity
A0U91_06460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A0U91_06490	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A0U91_06495	COG1396	sequence-specific DNA binding
A0U91_06505	COG0752	glycyl-tRNA synthetase alpha subunit
A0U91_06515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0U91_06525	COG0138	bifunctional purine biosynthesis protein purh
A0U91_06530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A0U91_06535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A0U91_06540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A0U91_06545	COG0484	heat shock protein binding
A0U91_06550	COG0443	Heat shock 70 kDa protein
A0U91_06555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A0U91_06560	COG0745	RESPONSE REGULATOR receiver
A0U91_06575	COG1660	Displays ATPase and GTPase activities
A0U91_06585	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A0U91_06595	COG1678	Uncharacterized ACR, COG1678
A0U91_06600	COG2326	polyphosphate kinase activity
A0U91_06615	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A0U91_06620	COG1686	Belongs to the peptidase S11 family
A0U91_06625	COG0024	Methionine aminopeptidase
A0U91_06660	COG0352	thiamine-phosphate diphosphorylase activity
A0U91_06690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A0U91_06695	COG1692	metallophosphoesterase
A0U91_06705	COG0167	dihydroorotate dehydrogenase activity
A0U91_06715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A0U91_06735	COG1215	transferase activity, transferring glycosyl groups
A0U91_06740	COG0612	Peptidase, M16
A0U91_06760	COG0556	nucleotide-excision repair
A0U91_06765	COG0667	Aldo Keto reductase
A0U91_06780	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A0U91_06790	COG1877	trehalose-phosphatase activity
A0U91_06820	COG0251	oxidation-reduction process
A0U91_06830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A0U91_06840	COG1881	PFAM PEBP family protein
A0U91_06850	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A0U91_06855	COG0343	queuine tRNA-ribosyltransferase activity
A0U91_06860	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A0U91_06870	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A0U91_06890	COG0488	(ABC) transporter
A0U91_06900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A0U91_06910	COG2353	YceI-like domain
A0U91_06920	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A0U91_06925	COG0450	alkyl hydroperoxide reductase
A0U91_06930	COG0583	DNA-binding transcription factor activity
A0U91_06940	COG0287	Prephenate dehydrogenase
A0U91_06950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0U91_06960	COG1562	ergosterol biosynthetic process
A0U91_06965	COG1562	ergosterol biosynthetic process
A0U91_06970	COG1233	COG1233 Phytoene dehydrogenase and related
A0U91_06975	COG1657	PFAM Prenyltransferase squalene oxidase
A0U91_06990	COG2010	Cytochrome c
A0U91_07010	COG1566	PFAM secretion protein HlyD family protein
A0U91_07020	COG1846	Transcriptional regulator
A0U91_07035	COG3842	ATPase activity
A0U91_07050	COG2983	Belongs to the UPF0260 family
A0U91_07080	COG1403	HNH endonuclease
A0U91_07100	COG4942	peptidase
A0U91_07125	COG1393	Belongs to the ArsC family
A0U91_07155	COG1289	transmembrane transporter activity
A0U91_07165	COG2818	Glycosylase
A0U91_07180	COG1733	regulation of RNA biosynthetic process
A0U91_07205	COG0723	plastoquinol--plastocyanin reductase activity
A0U91_07220	COG4178	(ABC) transporter
A0U91_07225	COG2217	Heavy metal translocating P-type atpase
A0U91_07235	COG1937	Protein conserved in bacteria
A0U91_07250	COG2132	Multicopper oxidase
A0U91_07260	COG2072	flavoprotein involved in K transport
A0U91_07290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A0U91_07295	COG0463	Glycosyl transferase, family 2
A0U91_07300	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A0U91_07305	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A0U91_07310	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A0U91_07315	COG0356	it plays a direct role in the translocation of protons across the membrane
A0U91_07325	COG0552	protein localization to endoplasmic reticulum
A0U91_07330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A0U91_07335	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A0U91_07340	COG0346	lactoylglutathione lyase activity
A0U91_07365	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0U91_07370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A0U91_07385	COG0704	Plays a role in the regulation of phosphate uptake
A0U91_07390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A0U91_07395	COG0581	inorganic phosphate transmembrane transporter activity
A0U91_07405	COG0129	dihydroxy-acid dehydratase activity
A0U91_07410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A0U91_07450	COG0489	protein tyrosine kinase activity
A0U91_07465	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A0U91_07485	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A0U91_07485	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A0U91_07495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U91_07500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A0U91_07505	COG1522	sequence-specific DNA binding
A0U91_07510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A0U91_07515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A0U91_07515	COG5373	membrane
A0U91_07530	COG0779	Required for maturation of 30S ribosomal subunits
A0U91_07550	COG0583	DNA-binding transcription factor activity
A0U91_07570	COG4133	protoheme IX ABC transporter activity
A0U91_07575	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A0U91_07580	COG0667	Aldo Keto reductase
A0U91_07610	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A0U91_07615	COG0511	ligase activity, forming carbon-carbon bonds
A0U91_07620	COG0439	Biotin carboxylase
A0U91_07630	COG2814	Major facilitator Superfamily
A0U91_07635	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A0U91_07650	COG5265	(ABC) transporter
A0U91_07655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A0U91_07660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A0U91_07700	COG0495	leucyl-tRNA aminoacylation
A0U91_07715	COG0582	viral genome integration into host DNA
A0U91_07800	COG4626	Terminase
A0U91_07800	COG1802	Transcriptional regulator
A0U91_07810	COG0616	signal peptide processing
A0U91_07920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A0U91_07940	COG0640	Transcriptional regulator
A0U91_07945	COG0450	alkyl hydroperoxide reductase
A0U91_07960	COG4988	ABC transporter
A0U91_07965	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A0U91_07970	COG1271	oxidase subunit
A0U91_07975	COG1294	oxidase, subunit
A0U91_07995	COG1522	sequence-specific DNA binding
A0U91_08005	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A0U91_08015	COG1280	lysine exporter protein (LysE YggA)
A0U91_08030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A0U91_08035	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A0U91_08045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A0U91_08050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A0U91_08055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A0U91_08060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A0U91_08065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A0U91_08095	COG0281	malic enzyme
A0U91_08105	COG0586	Pfam SNARE associated Golgi protein
A0U91_08110	COG1028	Short-chain dehydrogenase reductase Sdr
A0U91_08135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A0U91_08140	COG0443	Heat shock 70 kDa protein
A0U91_08160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0U91_08190	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A0U91_08210	COG0670	Belongs to the BI1 family
A0U91_08280	COG0776	regulation of translation
A0U91_08285	COG3754	Rhamnan synthesis protein F
A0U91_08300	COG1216	Glycosyl transferase, family 2
A0U91_08315	COG0131	Imidazoleglycerol-phosphate dehydratase
A0U91_08330	COG0107	imidazoleglycerol-phosphate synthase activity
A0U91_08335	COG0140	phosphoribosyl-ATP diphosphatase activity
A0U91_08345	COG0778	Nitroreductase
A0U91_08360	COG3237	CsbD-like
A0U91_08370	COG1475	DNA binding
A0U91_08375	COG1192	Involved in chromosome partitioning
A0U91_08380	COG0357	Ribosomal RNA small subunit methyltransferase G
A0U91_08390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A0U91_08395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A0U91_08435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0U91_08440	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A0U91_08445	COG0424	maF-like protein
A0U91_08460	COG2814	Major facilitator Superfamily
A0U91_08465	COG1228	amidohydrolase
A0U91_08475	COG2835	tetraacyldisaccharide 4'-kinase activity
A0U91_08480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A0U91_08505	COG1012	belongs to the aldehyde dehydrogenase family
A0U91_08510	COG0583	DNA-binding transcription factor activity
A0U91_08530	COG0778	Nitroreductase
A0U91_08550	COG1570	exodeoxyribonuclease VII activity
A0U91_08565	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A0U91_08590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A0U91_08600	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A0U91_08605	COG1053	succinate dehydrogenase
A0U91_08610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A0U91_08635	COG0126	phosphoglycerate kinase activity
A0U91_08655	COG0156	8-amino-7-oxononanoate synthase activity
A0U91_08685	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A0U91_08690	COG2943	transferase activity, transferring hexosyl groups
A0U91_08720	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A0U91_08725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A0U91_08730	COG1028	Short-chain dehydrogenase reductase Sdr
A0U91_08735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A0U91_08745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A0U91_08750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A0U91_08755	COG0539	negative regulation of cytoplasmic translation
A0U91_08765	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
A0U91_08770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A0U91_08775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A0U91_08780	COG1420	regulation of RNA biosynthetic process
A0U91_08830	COG1538	Outer membrane efflux protein
A0U91_08840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0U91_08845	COG2814	Major facilitator Superfamily
A0U91_08850	COG0772	Belongs to the SEDS family
A0U91_08855	COG0768	penicillin binding
A0U91_08875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A0U91_08880	COG1612	heme a metabolic process
A0U91_08885	COG2814	Major facilitator Superfamily
A0U91_08895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A0U91_08900	COG1289	transmembrane transporter activity
A0U91_08935	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A0U91_08945	COG0653	protein targeting
A0U91_08950	COG0217	transcriptional regulatory protein
A0U91_08955	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A0U91_08960	COG0632	four-way junction helicase activity
A0U91_08990	COG0823	Involved in the tonB-independent uptake of proteins
A0U91_09000	COG2885	chlorophyll binding
A0U91_09010	COG0037	tRNA processing
A0U91_09030	COG0352	thiamine-phosphate diphosphorylase activity
A0U91_09030	COG0351	phosphomethylpyrimidine kinase
A0U91_09040	COG0802	atpase or kinase
A0U91_09060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A0U91_09080	COG0215	cysteine-tRNA ligase activity
A0U91_09090	COG2945	thiolester hydrolase activity
A0U91_09100	COG1104	cysteine desulfurase activity
A0U91_09145	COG1091	dTDP-4-dehydrorhamnose reductase activity
A0U91_09150	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A0U91_09185	COG0312	modulator of DNA gyrase
A0U91_09190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A0U91_09205	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A0U91_09215	COG0629	single-stranded DNA binding
A0U91_09220	COG0742	ribosomal rna small subunit methyltransferase
A0U91_09225	COG1187	pseudouridine synthase activity
A0U91_09230	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A0U91_09235	COG0590	tRNA wobble adenosine to inosine editing
A0U91_09260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A0U91_09265	COG3047	cAMP biosynthetic process
A0U91_09270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A0U91_09300	COG1538	Outer membrane efflux protein
A0U91_09350	COG1024	Enoyl-CoA hydratase
A0U91_09355	COG2271	Major facilitator Superfamily
A0U91_09380	COG3119	arylsulfatase activity
A0U91_09400	COG0450	alkyl hydroperoxide reductase
A0U91_09440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A0U91_09470	COG4774	siderophore transport
A0U91_09475	COG3511	phospholipase C
A0U91_09485	COG2837	iron assimilation
A0U91_09490	COG3128	pkhd-type hydroxylase
A0U91_09525	COG2205	protein histidine kinase activity
A0U91_09530	COG0745	RESPONSE REGULATOR receiver
A0U91_09555	COG0295	cytidine deaminase activity
A0U91_09570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A0U91_09580	COG2995	paraquat-inducible protein a
A0U91_09585	COG3008	intermembrane lipid transfer
A0U91_09595	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A0U91_09600	COG1286	toxin biosynthetic process
A0U91_09610	COG1283	sodium-dependent phosphate transmembrane transporter activity
A0U91_09615	COG0646	methionine synthase
A0U91_09615	COG1410	methionine synthase
A0U91_09660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A0U91_09660	COG3008	intermembrane lipid transfer
A0U91_09665	COG1127	ABC transporter
A0U91_09670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A0U91_09675	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A0U91_09680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A0U91_09685	COG1185	polyribonucleotide nucleotidyltransferase activity
A0U91_09700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A0U91_09710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A0U91_09720	COG0583	DNA-binding transcription factor activity
A0U91_09730	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A0U91_09735	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A0U91_09740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A0U91_09745	COG0509	glycine decarboxylation via glycine cleavage system
A0U91_09750	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A0U91_09750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A0U91_09765	COG1408	metallophosphoesterase
A0U91_09770	COG1309	transcriptional regulator
A0U91_09795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A0U91_09805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0U91_09855	COG3293	Transposase
A0U91_09870	COG0531	amino acid
A0U91_09875	COG4771	TonB-dependent receptor
A0U91_09880	COG1506	peptidase
A0U91_09880	COG4946	Tricorn protease homolog
A0U91_09880	COG0823	Involved in the tonB-independent uptake of proteins
A0U91_09915	COG1741	Belongs to the pirin family
A0U91_09920	COG0583	DNA-binding transcription factor activity
A0U91_09925	COG0655	NAD(P)H dehydrogenase (quinone) activity
A0U91_09930	COG2259	Doxx family
A0U91_09940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A0U91_09945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A0U91_09960	COG0625	glutathione transferase activity
A0U91_09970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A0U91_09995	COG0814	amino acid
A0U91_10025	COG3293	Transposase
A0U91_10040	COG1111	helicase
A0U91_10040	COG1205	dead DEAH box helicase
A0U91_10045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A0U91_10070	COG2217	Heavy metal translocating P-type atpase
A0U91_10075	COG0038	chloride channel
A0U91_10175	COG0339	signal peptide processing
A0U91_10200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A0U91_10205	COG3158	transport of potassium into the cell
A0U91_10215	COG3321	synthase
A0U91_10215	COG0604	alcohol dehydrogenase
A0U91_10230	COG0277	FAD linked oxidase domain protein
A0U91_10265	COG0363	glucosamine-6-phosphate deaminase activity
A0U91_10270	COG0561	phosphatase activity
A0U91_10275	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A0U91_10280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A0U91_10300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A0U91_10330	COG1742	UPF0060 membrane protein
A0U91_10370	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A0U91_10380	COG1704	LemA family
A0U91_10395	COG4771	TonB-dependent receptor
A0U91_10400	COG1620	l-lactate permease
A0U91_10405	COG0741	lytic transglycosylase activity
A0U91_10430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A0U91_10430	COG0519	Catalyzes the synthesis of GMP from XMP
A0U91_10465	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A0U91_10490	COG0735	belongs to the Fur family
A0U91_10500	COG1121	(ABC) transporter
A0U91_10515	COG1250	3-hydroxyacyl-CoA dehydrogenase
A0U91_10515	COG1024	Enoyl-CoA hydratase
A0U91_10540	COG4771	TonB-dependent receptor
A0U91_10550	COG1289	transmembrane transporter activity
A0U91_10580	COG2814	Major facilitator Superfamily
A0U91_10615	COG1492	cobalamin metabolic process
A0U91_10630	COG0668	transmembrane transport
A0U91_10650	COG0583	DNA-binding transcription factor activity
A0U91_10675	COG3961	Belongs to the TPP enzyme family
A0U91_10690	COG0778	Nitroreductase
A0U91_10740	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A0U91_10745	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A0U91_10755	COG0584	glycerophosphoryl diester phosphodiesterase
A0U91_10780	COG0415	Belongs to the DNA photolyase family
A0U91_10790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0U91_10820	COG0628	permease
A0U91_10900	COG1956	GAF domain-containing protein
A0U91_10955	COG0640	Transcriptional regulator
A0U91_10960	COG0513	Belongs to the DEAD box helicase family
A0U91_11055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A0U91_11100	COG2032	superoxide dismutase activity
A0U91_11205	COG0753	catalase activity
A0U91_11310	COG4774	siderophore transport
A0U91_11345	COG3189	MarR family transcriptional regulator
A0U91_11355	COG1959	2 iron, 2 sulfur cluster binding
A0U91_11360	COG0306	phosphate transporter
A0U91_11365	COG1012	belongs to the aldehyde dehydrogenase family
A0U91_11370	COG1252	NADH dehydrogenase
A0U91_11410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A0U91_11415	COG4221	oxidoreductase activity
A0U91_11425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A0U91_11435	COG1278	Cold shock
A0U91_11460	COG1028	Short-chain dehydrogenase reductase Sdr
A0U91_11480	COG1607	acyl-coa hydrolase
A0U91_11485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A0U91_11490	COG0210	DNA helicase
A0U91_11530	COG3590	peptidase
A0U91_11550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0U91_11560	COG0477	Major facilitator Superfamily
A0U91_11580	COG3293	Transposase
A0U91_11585	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
A0U91_11635	COG1454	alcohol dehydrogenase
A0U91_11660	COG0708	Exodeoxyribonuclease III
A0U91_11665	COG0316	Belongs to the HesB IscA family
A0U91_11670	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A0U91_11675	COG0018	arginyl-trna synthetase
A0U91_11685	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A0U91_11695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A0U91_11705	COG0805	protein transport
A0U91_11710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A0U91_11720	COG0745	RESPONSE REGULATOR receiver
A0U91_11755	COG1695	Transcriptional regulator
A0U91_11760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A0U91_11765	COG1819	glycosyl
A0U91_11800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A0U91_11810	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A0U91_11815	COG1120	ATPase activity
A0U91_11820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0U91_11840	COG0564	pseudouridine synthase activity
A0U91_11845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A0U91_11855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A0U91_11860	COG1494	fructose-1,6-bisphosphatase
A0U91_11870	COG0436	Aminotransferase
A0U91_11880	COG0740	serine-type endopeptidase activity
A0U91_11900	COG0535	radical SAM domain protein
A0U91_11910	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A0U91_11915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A0U91_11940	COG3585	molybdate ion transport
A0U91_11970	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A0U91_11975	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A0U91_11985	COG1530	ribonuclease E activity
A0U91_11990	COG0860	N-Acetylmuramoyl-L-alanine amidase
A0U91_12060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A0U91_12070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A0U91_12080	COG0328	RNA-DNA hybrid ribonuclease activity
A0U91_12090	COG0242	peptide deformylase activity
A0U91_12140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A0U91_12145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A0U91_12175	COG2814	Major facilitator Superfamily
A0U91_12180	COG0488	(ABC) transporter
A0U91_12185	COG0105	UTP biosynthetic process
A0U91_12190	COG1032	radical SAM domain protein
A0U91_12195	COG3161	chorismate lyase activity
A0U91_12200	COG2217	Heavy metal translocating P-type atpase
A0U91_12215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0U91_12255	COG0251	oxidation-reduction process
A0U91_12260	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A0U91_12265	COG0667	Aldo Keto reductase
A0U91_12310	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
A0U91_12315	COG0587	DNA-directed DNA polymerase activity
A0U91_12325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A0U91_12340	COG0052	Belongs to the universal ribosomal protein uS2 family
A0U91_12345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A0U91_12350	COG1381	Involved in DNA repair and RecF pathway recombination
A0U91_12355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A0U91_12365	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A0U91_12370	COG0113	porphobilinogen synthase activity
A0U91_12375	COG0531	amino acid
A0U91_12380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A0U91_12390	COG1216	Glycosyl transferase, family 2
A0U91_12415	COG2824	Alkylphosphonate utilization operon protein PhnA
A0U91_12425	COG0560	Phosphoserine phosphatase
A0U91_12425	COG3830	Belongs to the UPF0237 family
A0U91_12430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A0U91_12435	COG0028	Belongs to the TPP enzyme family
A0U91_12445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A0U91_12455	COG1335	isochorismatase
A0U91_12460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0U91_12475	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A0U91_12500	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A0U91_12505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A0U91_12505	COG0574	Belongs to the PEP-utilizing enzyme family
A0U91_12515	COG0497	DNA recombination
A0U91_12520	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A0U91_12540	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A0U91_12545	COG1181	Belongs to the D-alanine--D-alanine ligase family
A0U91_12550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A0U91_12555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A0U91_12560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A0U91_12570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A0U91_12575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0U91_12580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A0U91_12585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A0U91_12600	COG0275	rRNA processing
A0U91_12605	COG2001	Belongs to the MraZ family
A0U91_12625	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A0U91_12630	COG3750	Belongs to the UPF0335 family
A0U91_12640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A0U91_12645	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A0U91_12655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A0U91_12685	COG2207	Transcriptional regulator
A0U91_12690	COG4303	Ethanolamine ammonia lyase large subunit
A0U91_12695	COG4302	ethanolamine ammonia-lyase activity
A0U91_12700	COG1113	amino acid transport
A0U91_12720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A0U91_12720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A0U91_12725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A0U91_12750	COG2814	Major facilitator Superfamily
A0U91_12780	COG1566	PFAM secretion protein HlyD family protein
A0U91_12810	COG0521	Mo-molybdopterin cofactor biosynthetic process
A0U91_12825	COG0302	gtp cyclohydrolase
A0U91_12830	COG2967	ApaG domain
A0U91_12840	COG0494	nUDIX hydrolase
A0U91_12880	COG4974	Belongs to the 'phage' integrase family
A0U91_12900	COG0004	ammonium transporteR
A0U91_12925	COG3293	Transposase
A0U91_12955	COG0347	Belongs to the P(II) protein family
A0U91_12960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0U91_12980	COG0459	protein refolding
A0U91_12985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A0U91_12990	COG0412	Dienelactone hydrolase
A0U91_13000	COG1199	ATP-dependent helicase activity
A0U91_13005	COG0483	inositol monophosphate 1-phosphatase activity
A0U91_13010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A0U91_13045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A0U91_13080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A0U91_13085	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A0U91_13110	COG0438	transferase activity, transferring glycosyl groups
A0U91_13125	COG1215	transferase activity, transferring glycosyl groups
A0U91_13130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A0U91_13130	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A0U91_13160	COG2204	response regulator
A0U91_13170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A0U91_13180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A0U91_13185	COG1051	belongs to the nudix hydrolase family
A0U91_13190	COG0542	response to heat
A0U91_13195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A0U91_13215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A0U91_13225	COG0659	secondary active sulfate transmembrane transporter activity
A0U91_13230	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0U91_13235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A0U91_13245	COG0367	asparagine synthase
A0U91_13250	COG0438	transferase activity, transferring glycosyl groups
A0U91_13275	COG1160	GTP binding
A0U91_13285	COG2814	Major facilitator Superfamily
A0U91_13290	COG3572	ergothioneine biosynthetic process
A0U91_13315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A0U91_13320	COG0564	pseudouridine synthase activity
A0U91_13345	COG0228	four-way junction DNA binding
A0U91_13350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A0U91_13355	COG0336	Belongs to the RNA methyltransferase TrmD family
A0U91_13360	COG0335	large ribosomal subunit rRNA binding
A0U91_13370	COG0066	3-isopropylmalate dehydratase activity
A0U91_13375	COG0473	3-isopropylmalate dehydrogenase activity
A0U91_13380	COG1505	serine-type exopeptidase activity
A0U91_13385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A0U91_13390	COG0242	peptide deformylase activity
A0U91_13405	COG0745	RESPONSE REGULATOR receiver
A0U91_13410	COG2205	protein histidine kinase activity
A0U91_13425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A0U91_13430	COG0416	fatty acid biosynthetic process
A0U91_13435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A0U91_13440	COG0776	regulation of translation
A0U91_13465	COG1573	uracil-dna glycosylase
A0U91_13470	COG0776	regulation of translation
A0U91_13485	COG0583	DNA-binding transcription factor activity
A0U91_13490	COG0492	ferredoxin-NADP+ reductase activity
A0U91_13495	COG1522	sequence-specific DNA binding
A0U91_13520	COG2226	methyltransferase
A0U91_13525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A0U91_13530	COG0109	protoheme IX farnesyltransferase activity
A0U91_13545	COG0312	modulator of DNA gyrase
A0U91_13550	COG0612	Peptidase, M16
A0U91_13575	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A0U91_13580	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A0U91_13590	COG5265	(ABC) transporter
A0U91_13600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A0U91_13605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A0U91_13630	COG2982	Protein involved in outer membrane biogenesis
A0U91_13650	COG0719	Fe-S assembly protein
A0U91_13655	COG0396	ATPase activity
A0U91_13660	COG0719	Fe-S assembly protein
A0U91_13665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A0U91_13675	COG2151	metal-sulfur cluster biosynthetic enzyme
A0U91_13680	COG0316	Belongs to the HesB IscA family
A0U91_13685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A0U91_13690	COG0513	Belongs to the DEAD box helicase family
A0U91_13700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A0U91_13700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A0U91_13710	COG0544	peptidyl-prolyl cis-trans isomerase activity
A0U91_13715	COG0740	serine-type endopeptidase activity
A0U91_13720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A0U91_13740	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U91_13745	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U91_13750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U91_13755	COG0649	NAD binding
A0U91_13760	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A0U91_13770	COG1034	ATP synthesis coupled electron transport
A0U91_13775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A0U91_13780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0U91_13790	COG0713	ATP synthesis coupled electron transport
A0U91_13800	COG1007	ATP synthesis coupled electron transport
A0U91_13810	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A0U91_13820	COG0442	prolyl-tRNA aminoacylation
A0U91_13830	COG1136	(ABC) transporter
A0U91_13835	COG0386	Belongs to the glutathione peroxidase family
A0U91_13850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A0U91_13855	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A0U91_13860	COG0546	phosphoglycolate phosphatase activity
A0U91_13865	COG0438	transferase activity, transferring glycosyl groups
A0U91_13915	COG0318	PFAM AMP-dependent synthetase and ligase
A0U91_13975	COG0784	Response regulator, receiver
A0U91_13975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A0U91_13995	COG5489	Protein of unknown function (DUF736)
A0U91_14000	COG1476	TRANSCRIPTIONal
A0U91_14040	COG0464	growth
A0U91_14075	COG3451	type IV secretory pathway VirB4
A0U91_14085	COG3846	protein secretion by the type IV secretion system
A0U91_14125	COG0837	glucose binding
A0U91_14125	COG1737	Transcriptional regulator
A0U91_14140	COG2207	Transcriptional regulator
A0U91_14155	COG1566	PFAM secretion protein HlyD family protein
A0U91_14185	COG2814	Major facilitator Superfamily
A0U91_14190	COG0583	DNA-binding transcription factor activity
A0U91_14235	COG0071	Belongs to the small heat shock protein (HSP20) family
A0U91_14245	COG2814	Major facilitator Superfamily
A0U91_14250	COG1335	isochorismatase
A0U91_14290	COG0793	Belongs to the peptidase S41A family
A0U91_14290	COG3409	Peptidoglycan-binding domain 1 protein
A0U91_14335	COG1538	Outer membrane efflux protein
A0U91_14355	COG0741	lytic transglycosylase activity
A0U91_14365	COG1450	Type ii and iii secretion system protein
A0U91_14380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A0U91_14385	COG1459	type II secretion system
A0U91_14435	COG4558	Periplasmic binding protein
A0U91_14440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0U91_14445	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A0U91_14460	COG4771	TonB-dependent receptor
A0U91_14470	COG0848	biopolymer transport protein
A0U91_14490	COG0484	heat shock protein binding
A0U91_14505	COG2943	transferase activity, transferring hexosyl groups
A0U91_14725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A0U91_14770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A0U91_14785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0U91_14980	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A0U91_14995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A0U91_15000	COG1360	Flagellar Motor Protein
A0U91_15015	COG1157	protein secretion by the type III secretion system
A0U91_15045	COG1706	bacterial-type flagellum-dependent cell motility
A0U91_15060	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A0U91_15070	COG1338	Plays a role in the flagellum-specific transport system
A0U91_15080	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A0U91_15090	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A0U91_15095	COG1766	The M ring may be actively involved in energy transduction
A0U91_15110	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A0U91_15120	COG4786	Flagellar basal body rod
A0U91_15125	COG4786	Flagellar basal body rod
A0U91_15160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A0U91_15165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A0U91_15195	COG1987	bacterial-type flagellum assembly
A0U91_15205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A0U91_15210	COG1749	Flagellar hook protein flgE
A0U91_15215	COG0840	transmembrane signaling receptor activity
A0U91_15225	COG3750	Belongs to the UPF0335 family
A0U91_15250	COG2176	DNA-directed DNA polymerase activity
A0U91_15290	COG0194	GDP metabolic process
A0U91_15385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A0U91_15415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A0U91_15435	COG2894	cell division
A0U91_15515	COG0306	phosphate transporter
A0U91_15590	COG0210	DNA helicase
A0U91_15595	COG0587	DNA-directed DNA polymerase activity
A0U91_15605	COG0745	RESPONSE REGULATOR receiver
A0U91_15690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A0U91_15915	COG1857	crispr-associated protein
A0U91_15960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A0U91_15960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A0U91_16020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A0U91_16120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A0U91_16270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A0U91_16440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A0U91_16485	COG0629	single-stranded DNA binding
A0U91_16490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A0U91_16530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A0U91_16530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A0U91_16545	COG0840	transmembrane signaling receptor activity
A0U91_16565	COG0835	chemotaxis
A0U91_16570	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A0U91_16575	COG2201	protein-glutamate methylesterase activity
A0U91_16580	COG0745	RESPONSE REGULATOR receiver
A0U91_16625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A0U91_16645	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A0U91_16675	COG0270	DNA (cytosine-5-)-methyltransferase activity
A0U91_16740	COG0675	Transposase, IS605 OrfB family
A0U91_16775	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A0U91_16780	COG0187	DNA topoisomerase II activity
A0U91_16960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A0U91_17005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A0U91_17125	COG3550	peptidyl-serine autophosphorylation