locus-tag	class	description
CPF11_00005	COG0583	DNA-binding transcription factor activity
CPF11_00010	COG1902	pentaerythritol trinitrate reductase activity
CPF11_00045	COG0640	Transcriptional regulator
CPF11_00055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CPF11_00060	COG0735	belongs to the Fur family
CPF11_00070	COG0302	gtp cyclohydrolase
CPF11_00075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CPF11_00080	COG0523	cobalamin synthesis protein
CPF11_00145	COG2207	Transcriptional regulator
CPF11_00180	COG4962	Type ii secretion system protein e
CPF11_00185	COG3838	Conjugal transfer protein Trbc
CPF11_00195	COG3451	type IV secretory pathway VirB4
CPF11_00205	COG3846	protein secretion by the type IV secretion system
CPF11_00230	COG0583	DNA-binding transcription factor activity
CPF11_00235	COG1595	DNA-templated transcription, initiation
CPF11_00245	COG4774	siderophore transport
CPF11_00265	COG0848	biopolymer transport protein
CPF11_00310	COG4974	Belongs to the 'phage' integrase family
CPF11_00315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPF11_00335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CPF11_00375	COG2801	Transposase and inactivated derivatives
CPF11_00380	COG2842	Transposition protein
CPF11_00450	COG4373	Mu-like prophage FluMu protein gp28
CPF11_00490	COG4397	Mu-like prophage major head subunit gpT
CPF11_00610	COG0848	biopolymer transport protein
CPF11_00625	COG1914	H( )-stimulated, divalent metal cation uptake system
CPF11_00630	COG1321	iron dependent repressor
CPF11_00640	COG4558	Periplasmic binding protein
CPF11_00645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPF11_00650	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CPF11_00675	COG1960	acyl-CoA dehydrogenase activity
CPF11_00685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CPF11_00710	COG3665	Urea carboxylase-associated protein
CPF11_00715	COG3665	Urea carboxylase-associated protein
CPF11_00720	COG0864	Transcriptional regulator
CPF11_00725	COG1116	anion transmembrane transporter activity
CPF11_00730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CPF11_00740	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CPF11_00745	COG0477	Major facilitator Superfamily
CPF11_00815	COG4178	(ABC) transporter
CPF11_00850	COG3459	Glycosyltransferase 36 associated
CPF11_00865	COG0753	catalase activity
CPF11_00870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CPF11_00890	COG1657	PFAM Prenyltransferase squalene oxidase
CPF11_00905	COG0842	Transport permease protein
CPF11_00910	COG1129	ABC transporter
CPF11_00910	COG0842	Transport permease protein
CPF11_00915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CPF11_00950	COG0402	S-adenosylhomocysteine deaminase activity
CPF11_00960	COG2072	flavoprotein involved in K transport
CPF11_00975	COG2351	hydroxyisourate hydrolase activity
CPF11_00980	COG2233	PERMEase
CPF11_00990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CPF11_01015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CPF11_01025	COG4206	TonB-dependent receptor
CPF11_01065	COG0384	phenazine biosynthesis protein PhzF
CPF11_01075	COG0814	amino acid
CPF11_01080	COG2824	Alkylphosphonate utilization operon protein PhnA
CPF11_01100	COG0784	Response regulator, receiver
CPF11_01125	COG4988	ABC transporter
CPF11_01130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CPF11_01145	COG1349	DNA-binding transcription factor activity
CPF11_01155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CPF11_01160	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CPF11_01170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CPF11_01175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CPF11_01180	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CPF11_01185	COG0456	acetyltransferase
CPF11_01190	COG1028	Short-chain dehydrogenase reductase Sdr
CPF11_01215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CPF11_01230	COG0525	valine-tRNA ligase activity
CPF11_01235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CPF11_01240	COG1116	anion transmembrane transporter activity
CPF11_01245	COG1176	ABC-type spermidine putrescine transport system, permease component I
CPF11_01250	COG0756	dUTP diphosphatase activity
CPF11_01255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CPF11_01260	COG2226	methyltransferase
CPF11_01265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CPF11_01270	COG0268	Binds directly to 16S ribosomal RNA
CPF11_01275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CPF11_01280	COG0592	DNA-directed DNA polymerase activity
CPF11_01285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CPF11_01290	COG0187	DNA topoisomerase II activity
CPF11_01295	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CPF11_01300	COG0504	CTP synthase activity
CPF11_01310	COG0149	triose-phosphate isomerase activity
CPF11_01320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CPF11_01330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CPF11_01335	COG0134	indole-3-glycerol-phosphate synthase activity
CPF11_01340	COG0315	cyclic pyranopterin monophosphate synthase activity
CPF11_01345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CPF11_01350	COG0022	dehydrogenase e1 component
CPF11_01350	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPF11_01355	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPF11_01360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CPF11_01365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CPF11_01380	COG1546	Belongs to the CinA family
CPF11_01395	COG0861	Integral membrane protein TerC family
CPF11_01400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CPF11_01405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CPF11_01410	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPF11_01420	COG0047	phosphoribosylformylglycinamidine synthase activity
CPF11_01425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPF11_01430	COG0271	Belongs to the BolA IbaG family
CPF11_01435	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CPF11_01445	COG0792	nuclease activity
CPF11_01460	COG0628	permease
CPF11_01465	COG2897	thiosulfate sulfurtransferase activity
CPF11_01470	COG0626	cystathionine gamma-synthase activity
CPF11_01475	COG0606	chelatase, subunit chli
CPF11_01480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CPF11_01490	COG3474	cytochrome
CPF11_01495	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CPF11_01500	COG0077	Prephenate dehydratase
CPF11_01500	COG1605	Chorismate mutase
CPF11_01505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CPF11_01510	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CPF11_01515	COG1278	Cold shock
CPF11_01545	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CPF11_01555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CPF11_01560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CPF11_01565	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CPF11_01585	COG1663	tetraacyldisaccharide 4'-kinase activity
CPF11_01590	COG1519	Transferase
CPF11_01600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CPF11_01615	COG0175	sulfate reduction
CPF11_01620	COG0175	sulfate reduction
CPF11_01630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CPF11_01635	COG0602	queuosine metabolic process
CPF11_01640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CPF11_01650	COG0579	oxidoreductase
CPF11_01655	COG1764	response to oxidative stress
CPF11_01660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CPF11_01665	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CPF11_01670	COG0259	pyridoxamine-phosphate oxidase activity
CPF11_01685	COG0084	hydrolase, TatD family'
CPF11_01700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CPF11_01705	COG1686	Belongs to the peptidase S11 family
CPF11_01710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CPF11_01715	COG2951	lytic endotransglycosylase activity
CPF11_01730	COG0531	amino acid
CPF11_01735	COG1968	undecaprenyl-diphosphatase activity
CPF11_01760	COG2890	protein-(glutamine-N5) methyltransferase activity
CPF11_01770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CPF11_01775	COG0124	histidyl-tRNA synthetase
CPF11_01780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CPF11_01790	COG2070	2-Nitropropane dioxygenase
CPF11_01795	COG0527	aspartate kinase activity
CPF11_01800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CPF11_01805	COG2706	6-phosphogluconolactonase activity
CPF11_01830	COG2226	methyltransferase
CPF11_01835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CPF11_01855	COG0321	lipoyl(octanoyl) transferase activity
CPF11_01865	COG0271	Belongs to the BolA IbaG family
CPF11_01870	COG0484	heat shock protein binding
CPF11_01885	COG0076	glutamate decarboxylase activity
CPF11_01900	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CPF11_01905	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CPF11_01920	COG2022	thiamine diphosphate biosynthetic process
CPF11_01940	COG0148	phosphopyruvate hydratase activity
CPF11_01950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CPF11_01955	COG0303	'Molybdopterin
CPF11_01960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CPF11_01965	COG4106	trans-aconitate 2-methyltransferase activity
CPF11_01965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CPF11_01975	COG0156	8-amino-7-oxononanoate synthase activity
CPF11_01980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CPF11_01990	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CPF11_02005	COG0322	excinuclease ABC activity
CPF11_02025	COG0729	surface antigen
CPF11_02035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CPF11_02045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CPF11_02055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CPF11_02080	COG0287	Prephenate dehydrogenase
CPF11_02080	COG1605	Chorismate mutase
CPF11_02085	COG2062	phosphohistidine phosphatase, SixA
CPF11_02100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CPF11_02105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CPF11_02110	COG0142	geranyltranstransferase activity
CPF11_02120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPF11_02125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPF11_02125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CPF11_02135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPF11_02140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPF11_02150	COG1970	mechanosensitive ion channel activity
CPF11_02155	COG0254	rRNA binding
CPF11_02160	COG0071	Belongs to the small heat shock protein (HSP20) family
CPF11_02185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CPF11_02190	COG2003	Belongs to the UPF0758 family
CPF11_02195	COG2003	Belongs to the UPF0758 family
CPF11_02205	COG2264	protein methyltransferase activity
CPF11_02210	COG0006	proline dipeptidase activity
CPF11_02215	COG0473	3-isopropylmalate dehydrogenase activity
CPF11_02230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CPF11_02255	COG0747	negative chemotaxis
CPF11_02260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CPF11_02265	COG0072	phenylalanine-tRNA ligase activity
CPF11_02265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPF11_02270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CPF11_02275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CPF11_02280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CPF11_02285	COG0246	Mannitol dehydrogenase
CPF11_02290	COG2010	Cytochrome c
CPF11_02290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CPF11_02305	COG2166	iron-sulfur cluster assembly
CPF11_02310	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CPF11_02315	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CPF11_02340	COG2884	Cell division ATP-binding protein ftsE
CPF11_02355	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CPF11_02360	COG3781	membrane
CPF11_02370	COG0859	PFAM glycosyl transferase family 9
CPF11_02370	COG0457	Tetratricopeptide repeat
CPF11_02380	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CPF11_02385	COG2081	HI0933 family
CPF11_02395	COG0850	regulation of cytokinetic process
CPF11_02405	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CPF11_02410	COG1802	Transcriptional regulator
CPF11_02415	COG1132	(ABC) transporter
CPF11_02445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CPF11_02450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CPF11_02455	COG0359	binds to the 23S rRNA
CPF11_02460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CPF11_02465	COG0360	Binds together with S18 to 16S ribosomal RNA
CPF11_02475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CPF11_02490	COG0505	Belongs to the CarA family
CPF11_02495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CPF11_02500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CPF11_02505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CPF11_02510	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CPF11_02525	COG0793	Belongs to the peptidase S41A family
CPF11_02535	COG1051	belongs to the nudix hydrolase family
CPF11_02540	COG2814	Major facilitator Superfamily
CPF11_02550	COG1132	(ABC) transporter
CPF11_02555	COG0617	tRNA 3'-terminal CCA addition
CPF11_02565	COG0714	Associated with various cellular activities
CPF11_02590	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CPF11_02595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CPF11_02600	COG3237	CsbD-like
CPF11_02610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CPF11_02625	COG1538	Outer membrane efflux protein
CPF11_02630	COG5487	UPF0391 membrane protein
CPF11_02640	COG1116	anion transmembrane transporter activity
CPF11_02645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CPF11_02655	COG0203	ribosomal protein L17
CPF11_02660	COG0202	RNA polymerase activity
CPF11_02665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CPF11_02670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CPF11_02675	COG0563	adenylate kinase activity
CPF11_02680	COG0201	protein transport
CPF11_02685	COG0200	Binds to the 23S rRNA
CPF11_02690	COG1841	ribosomal large subunit assembly
CPF11_02695	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CPF11_02700	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CPF11_02705	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CPF11_02710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CPF11_02715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CPF11_02720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CPF11_02725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CPF11_02730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CPF11_02735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CPF11_02740	COG0255	Belongs to the universal ribosomal protein uL29 family
CPF11_02745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CPF11_02750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CPF11_02755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CPF11_02760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CPF11_02765	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CPF11_02770	COG0089	rRNA binding
CPF11_02775	COG0088	Forms part of the polypeptide exit tunnel
CPF11_02780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CPF11_02785	COG0051	transcription antitermination factor activity, RNA binding
CPF11_02790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CPF11_02795	COG0049	tRNA binding
CPF11_02800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CPF11_02805	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CPF11_02810	COG0085	RNA polymerase activity
CPF11_02820	COG0222	ribosome binding
CPF11_02825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CPF11_02830	COG0081	regulation of translation
CPF11_02835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CPF11_02865	COG1322	Protein conserved in bacteria
CPF11_02870	COG0477	Major facilitator Superfamily
CPF11_02880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CPF11_02910	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CPF11_02945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CPF11_02950	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CPF11_02955	COG1138	Cytochrome C-type biogenesis protein
CPF11_02960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CPF11_02965	COG3088	subunit of a heme lyase
CPF11_02985	COG1289	transmembrane transporter activity
CPF11_02990	COG1289	transmembrane transporter activity
CPF11_03015	COG1121	(ABC) transporter
CPF11_03030	COG0248	Ppx GppA phosphatase
CPF11_03035	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CPF11_03045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CPF11_03050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CPF11_03060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CPF11_03080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CPF11_03085	COG0237	dephospho-CoA kinase activity
CPF11_03090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CPF11_03110	COG0165	Argininosuccinate lyase
CPF11_03115	COG0019	diaminopimelate decarboxylase activity
CPF11_03125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CPF11_03130	COG3591	Belongs to the peptidase S1B family
CPF11_03140	COG0640	Transcriptional regulator
CPF11_03145	COG1902	pentaerythritol trinitrate reductase activity
CPF11_03150	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CPF11_03240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPF11_03300	COG0582	viral genome integration into host DNA
CPF11_03335	COG1518	maintenance of DNA repeat elements
CPF11_03420	COG0778	Nitroreductase
CPF11_03440	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CPF11_03445	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CPF11_03445	COG2857	Cytochrome c1
CPF11_03450	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CPF11_03450	COG2857	Cytochrome c1
CPF11_03455	COG0408	coproporphyrinogen oxidase activity
CPF11_03475	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CPF11_03485	COG0406	alpha-ribazole phosphatase activity
CPF11_03490	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CPF11_03500	COG0181	hydroxymethylbilane synthase activity
CPF11_03505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CPF11_03510	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CPF11_03525	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CPF11_03530	COG1546	Belongs to the CinA family
CPF11_03530	COG1058	Belongs to the CinA family
CPF11_03535	COG0825	malonyl-CoA metabolic process
CPF11_03540	COG4974	Belongs to the 'phage' integrase family
CPF11_03550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CPF11_03555	COG2885	chlorophyll binding
CPF11_03555	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CPF11_03565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CPF11_03570	COG0688	phosphatidylethanolamine metabolic process
CPF11_03575	COG1183	phosphatidylcholine synthase activity
CPF11_03580	COG3260	NADH ubiquinone oxidoreductase 20
CPF11_03615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPF11_03630	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CPF11_03650	COG0508	dehydrogenase complex catalyzes the overall conversion of
CPF11_03660	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CPF11_03665	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CPF11_03670	COG2333	competence protein COMEC
CPF11_03670	COG0658	competence protein
CPF11_03675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CPF11_03680	COG0540	Belongs to the ATCase OTCase family
CPF11_03685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CPF11_03690	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CPF11_03695	COG0758	DNA mediated transformation
CPF11_03700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CPF11_03705	COG0557	exoribonuclease II activity
CPF11_03710	COG0793	Belongs to the peptidase S41A family
CPF11_03720	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CPF11_03720	COG2885	chlorophyll binding
CPF11_03725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CPF11_03730	COG1959	2 iron, 2 sulfur cluster binding
CPF11_03745	COG0187	DNA topoisomerase II activity
CPF11_03750	COG5006	permease, DMT superfamily
CPF11_03760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CPF11_03770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CPF11_03775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CPF11_03780	COG0196	riboflavin kinase activity
CPF11_03785	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CPF11_03790	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CPF11_03795	COG0235	Class ii aldolase
CPF11_03800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CPF11_03815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CPF11_03820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CPF11_03830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CPF11_03840	COG1643	Atp-dependent helicase
CPF11_03850	COG0656	L-ascorbic acid biosynthetic process
CPF11_03860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CPF11_03870	COG0009	L-threonylcarbamoyladenylate synthase
CPF11_03880	COG0277	FAD linked oxidase domain protein
CPF11_03895	COG2096	Adenosyltransferase
CPF11_03925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CPF11_03940	COG0506	proline dehydrogenase activity
CPF11_03940	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CPF11_03940	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CPF11_03950	COG1113	amino acid transport
CPF11_03980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CPF11_03985	COG1127	ABC transporter
CPF11_03990	COG3264	Mechanosensitive ion channel
CPF11_03990	COG1196	nuclear chromosome segregation
CPF11_03995	COG0305	Participates in initiation and elongation during chromosome replication
CPF11_04000	COG2942	2-epimerase
CPF11_04005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CPF11_04005	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CPF11_04010	COG0194	GDP metabolic process
CPF11_04020	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CPF11_04025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPF11_04035	COG0517	IMP dehydrogenase activity
CPF11_04035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CPF11_04050	COG1137	ATPase activity
CPF11_04055	COG3217	Mosc domain protein beta barrel domain protein
CPF11_04055	COG0633	Ferredoxin
CPF11_04065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CPF11_04085	COG0242	peptide deformylase activity
CPF11_04090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CPF11_04095	COG0101	tRNA pseudouridine synthase activity
CPF11_04105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPF11_04110	COG2171	N-acyltransferase activity
CPF11_04115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CPF11_04120	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CPF11_04125	COG0706	membrane insertase activity
CPF11_04130	COG0594	ribonuclease P activity
CPF11_04135	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CPF11_04145	COG0346	lactoylglutathione lyase activity
CPF11_04150	COG3494	Protein of unknown function (DUF1009)
CPF11_04155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CPF11_04160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CPF11_04165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CPF11_04180	COG0750	zinc metalloprotease
CPF11_04185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CPF11_04195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CPF11_04200	COG0233	cytoplasmic translational termination
CPF11_04205	COG0528	UMP kinase activity
CPF11_04210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CPF11_04215	COG0571	ribonuclease III activity
CPF11_04220	COG0681	Belongs to the peptidase S26 family
CPF11_04225	COG0736	holo-[acyl-carrier-protein] synthase activity
CPF11_04230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CPF11_04235	COG1758	RNA polymerase activity
CPF11_04260	COG0513	Belongs to the DEAD box helicase family
CPF11_04265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CPF11_04265	COG2813	Specifically methylates the guanine in position
CPF11_04270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CPF11_04275	COG0481	GTPase activity
CPF11_04290	COG4993	Dehydrogenase
CPF11_04335	COG0538	isocitrate dehydrogenase activity
CPF11_04340	COG0492	ferredoxin-NADP+ reductase activity
CPF11_04345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CPF11_04375	COG0469	pyruvate kinase activity
CPF11_04385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CPF11_04420	COG1297	OPT oligopeptide transporter protein
CPF11_04435	COG0596	Alpha beta hydrolase
CPF11_04440	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CPF11_04450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CPF11_04460	COG0523	cobalamin synthesis protein
CPF11_04470	COG1252	NADH dehydrogenase
CPF11_04480	COG0071	Belongs to the small heat shock protein (HSP20) family
CPF11_04490	COG0022	dehydrogenase e1 component
CPF11_04495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CPF11_04505	COG0306	phosphate transporter
CPF11_04545	COG1607	acyl-coa hydrolase
CPF11_04570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CPF11_04575	COG4221	oxidoreductase activity
CPF11_04580	COG1959	2 iron, 2 sulfur cluster binding
CPF11_04850	COG4774	siderophore transport
CPF11_04990	COG1012	belongs to the aldehyde dehydrogenase family
CPF11_05030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CPF11_05075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CPF11_05105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CPF11_05110	COG0415	Belongs to the DNA photolyase family
CPF11_05130	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CPF11_05135	COG2971	BadF BadG BcrA BcrD
CPF11_05140	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CPF11_05145	COG1120	ATPase activity
CPF11_05150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPF11_05160	COG4771	TonB-dependent receptor
CPF11_05165	COG0025	NhaP-type Na H and K H
CPF11_05170	COG0583	DNA-binding transcription factor activity
CPF11_05175	COG1028	Short-chain dehydrogenase reductase Sdr
CPF11_05215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CPF11_05255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CPF11_05265	COG1573	uracil-dna glycosylase
CPF11_05270	COG0741	lytic transglycosylase activity
CPF11_05275	COG1253	flavin adenine dinucleotide binding
CPF11_05280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CPF11_05295	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CPF11_05315	COG3394	polysaccharide catabolic process
CPF11_05330	COG0717	Belongs to the dCTP deaminase family
CPF11_05335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CPF11_05340	COG0697	spore germination
CPF11_05350	COG1139	Iron-sulfur cluster binding protein
CPF11_05355	COG0247	lactate metabolic process
CPF11_05390	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CPF11_05395	COG0799	negative regulation of ribosome biogenesis
CPF11_05400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CPF11_05405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CPF11_05410	COG0012	GTP binding
CPF11_05415	COG0193	aminoacyl-tRNA hydrolase activity
CPF11_05420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CPF11_05430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CPF11_05445	COG2309	aminopeptidase activity
CPF11_05455	COG2319	Wd-40 repeat
CPF11_05460	COG2814	Major facilitator Superfamily
CPF11_05465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CPF11_05470	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CPF11_05475	COG0372	Belongs to the citrate synthase family
CPF11_05480	COG2079	MmgE PrpD family protein
CPF11_05485	COG3800	Transcriptional regulator
CPF11_05485	COG1396	sequence-specific DNA binding
CPF11_05510	COG2755	lipolytic protein G-D-S-L family
CPF11_05510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CPF11_05570	COG2223	nitrite transmembrane transporter activity
CPF11_05600	COG0318	PFAM AMP-dependent synthetase and ligase
CPF11_05625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CPF11_05655	COG0326	Molecular chaperone. Has ATPase activity
CPF11_05665	COG3956	TIGRFAM MazG family protein
CPF11_05670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CPF11_05675	COG1028	Short-chain dehydrogenase reductase Sdr
CPF11_05690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CPF11_05700	COG0604	alcohol dehydrogenase
CPF11_05705	COG1253	flavin adenine dinucleotide binding
CPF11_05730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CPF11_05740	COG0745	RESPONSE REGULATOR receiver
CPF11_05745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CPF11_05750	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CPF11_05760	COG0493	'glutamate synthase
CPF11_05765	COG0159	tryptophan synthase activity
CPF11_05770	COG0133	tryptophan synthase activity
CPF11_05795	COG0598	Magnesium transport protein CorA
CPF11_05805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CPF11_05825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CPF11_05830	COG1396	sequence-specific DNA binding
CPF11_05840	COG0752	glycyl-tRNA synthetase alpha subunit
CPF11_05850	COG0697	spore germination
CPF11_05865	COG0138	bifunctional purine biosynthesis protein purh
CPF11_05870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CPF11_05875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CPF11_05885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CPF11_05890	COG0484	heat shock protein binding
CPF11_05895	COG0443	Heat shock 70 kDa protein
CPF11_05900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CPF11_05905	COG0745	RESPONSE REGULATOR receiver
CPF11_05910	COG2205	protein histidine kinase activity
CPF11_05920	COG1660	Displays ATPase and GTPase activities
CPF11_05925	COG1678	Uncharacterized ACR, COG1678
CPF11_05930	COG2326	polyphosphate kinase activity
CPF11_05945	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CPF11_05950	COG1686	Belongs to the peptidase S11 family
CPF11_05955	COG0024	Methionine aminopeptidase
CPF11_05965	COG1509	lysine 2,3-aminomutase activity
CPF11_05990	COG0352	thiamine-phosphate diphosphorylase activity
CPF11_06020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CPF11_06025	COG1692	metallophosphoesterase
CPF11_06040	COG0167	dihydroorotate dehydrogenase activity
CPF11_06050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CPF11_06065	COG0463	Glycosyl transferase, family 2
CPF11_06085	COG0612	Peptidase, M16
CPF11_06095	COG0556	nucleotide-excision repair
CPF11_06105	COG0667	Aldo Keto reductase
CPF11_06120	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CPF11_06125	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CPF11_06155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPF11_06170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CPF11_06185	COG1881	PFAM PEBP family protein
CPF11_06195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CPF11_06200	COG0343	queuine tRNA-ribosyltransferase activity
CPF11_06205	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CPF11_06215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CPF11_06235	COG0488	(ABC) transporter
CPF11_06245	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CPF11_06255	COG2353	YceI-like domain
CPF11_06265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CPF11_06270	COG0450	alkyl hydroperoxide reductase
CPF11_06280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CPF11_06290	COG0287	Prephenate dehydrogenase
CPF11_06300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CPF11_06305	COG1215	transferase activity, transferring glycosyl groups
CPF11_06310	COG1562	ergosterol biosynthetic process
CPF11_06315	COG1562	ergosterol biosynthetic process
CPF11_06320	COG1233	COG1233 Phytoene dehydrogenase and related
CPF11_06325	COG1657	PFAM Prenyltransferase squalene oxidase
CPF11_06345	COG1566	PFAM secretion protein HlyD family protein
CPF11_06385	COG2983	Belongs to the UPF0260 family
CPF11_06455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CPF11_06510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CPF11_06555	COG0411	ABC transporter
CPF11_06575	COG0784	Response regulator, receiver
CPF11_06575	COG2198	Histidine kinase
CPF11_06575	COG5002	protein histidine kinase activity
CPF11_06580	COG0745	RESPONSE REGULATOR receiver
CPF11_06585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CPF11_06625	COG1278	Cold shock
CPF11_06630	COG1538	Outer membrane efflux protein
CPF11_06645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CPF11_06650	COG1113	amino acid transport
CPF11_06655	COG4302	ethanolamine ammonia-lyase activity
CPF11_06660	COG4303	Ethanolamine ammonia lyase large subunit
CPF11_06665	COG2207	Transcriptional regulator
CPF11_06670	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CPF11_06690	COG4208	sulfate ABC transporter
CPF11_06695	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CPF11_06700	COG1113	amino acid transport
CPF11_06715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPF11_06720	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CPF11_06725	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CPF11_06730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CPF11_06735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CPF11_06740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CPF11_06745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CPF11_06750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CPF11_06780	COG0281	malic enzyme
CPF11_06790	COG0586	Pfam SNARE associated Golgi protein
CPF11_06795	COG1028	Short-chain dehydrogenase reductase Sdr
CPF11_06820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CPF11_06840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CPF11_06855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CPF11_06870	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CPF11_06895	COG0670	Belongs to the BI1 family
CPF11_06915	COG1573	uracil-dna glycosylase
CPF11_06925	COG1289	transmembrane transporter activity
CPF11_06930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CPF11_06940	COG2814	Major facilitator Superfamily
CPF11_06950	COG1612	heme a metabolic process
CPF11_06955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CPF11_06975	COG0768	penicillin binding
CPF11_06980	COG0772	Belongs to the SEDS family
CPF11_07015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CPF11_07020	COG1420	regulation of RNA biosynthetic process
CPF11_07025	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CPF11_07030	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CPF11_07045	COG0539	negative regulation of cytoplasmic translation
CPF11_07050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CPF11_07055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CPF11_07065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CPF11_07075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CPF11_07080	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CPF11_07105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CPF11_07115	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CPF11_07135	COG0405	Gamma-glutamyltransferase
CPF11_07140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CPF11_07145	COG0156	8-amino-7-oxononanoate synthase activity
CPF11_07155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CPF11_07165	COG0126	phosphoglycerate kinase activity
CPF11_07180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CPF11_07185	COG1053	succinate dehydrogenase
CPF11_07190	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CPF11_07200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CPF11_07210	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CPF11_07215	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CPF11_07225	COG1012	belongs to the aldehyde dehydrogenase family
CPF11_07230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CPF11_07245	COG1570	exodeoxyribonuclease VII activity
CPF11_07255	COG0456	acetyltransferase
CPF11_07265	COG0778	Nitroreductase
CPF11_07290	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CPF11_07300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CPF11_07305	COG2835	tetraacyldisaccharide 4'-kinase activity
CPF11_07315	COG2814	Major facilitator Superfamily
CPF11_07325	COG1671	Belongs to the UPF0178 family
CPF11_07340	COG0424	maF-like protein
CPF11_07345	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CPF11_07365	COG2814	Major facilitator Superfamily
CPF11_07370	COG1611	Belongs to the LOG family
CPF11_07390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CPF11_07395	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CPF11_07400	COG0445	tRNA wobble uridine modification
CPF11_07405	COG0357	Ribosomal RNA small subunit methyltransferase G
CPF11_07410	COG1192	Involved in chromosome partitioning
CPF11_07415	COG1475	DNA binding
CPF11_07515	COG0778	Nitroreductase
CPF11_07525	COG0140	phosphoribosyl-ATP diphosphatase activity
CPF11_07530	COG0107	imidazoleglycerol-phosphate synthase activity
CPF11_07535	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CPF11_07540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CPF11_07545	COG0131	Imidazoleglycerol-phosphate dehydratase
CPF11_07560	COG1216	Glycosyl transferase, family 2
CPF11_07580	COG0776	regulation of translation
CPF11_07640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CPF11_07645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CPF11_07650	COG0653	protein targeting
CPF11_07655	COG0217	transcriptional regulatory protein
CPF11_07660	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CPF11_07665	COG0632	four-way junction helicase activity
CPF11_07670	COG2255	four-way junction helicase activity
CPF11_07675	COG0824	Thioesterase
CPF11_07685	COG0848	biopolymer transport protein
CPF11_07695	COG0823	Involved in the tonB-independent uptake of proteins
CPF11_07700	COG2885	chlorophyll binding
CPF11_07710	COG0037	tRNA processing
CPF11_07715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CPF11_07725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPF11_07730	COG0745	RESPONSE REGULATOR receiver
CPF11_07735	COG0802	atpase or kinase
CPF11_07740	COG2887	Belongs to the helicase family. UvrD subfamily
CPF11_07745	COG1074	ATP-dependent DNA helicase activity
CPF11_07755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CPF11_07760	COG0285	dihydrofolate synthase activity
CPF11_07770	COG0215	cysteine-tRNA ligase activity
CPF11_07780	COG2945	thiolester hydrolase activity
CPF11_07790	COG1104	cysteine desulfurase activity
CPF11_07800	COG0482	sulfurtransferase activity
CPF11_07815	COG0564	pseudouridine synthase activity
CPF11_07820	COG1674	ftsk spoiiie
CPF11_07830	COG1091	dTDP-4-dehydrorhamnose reductase activity
CPF11_07835	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CPF11_07855	COG0406	alpha-ribazole phosphatase activity
CPF11_07860	COG0312	modulator of DNA gyrase
CPF11_07865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CPF11_07885	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CPF11_07895	COG0629	single-stranded DNA binding
CPF11_07900	COG0742	ribosomal rna small subunit methyltransferase
CPF11_07905	COG1187	pseudouridine synthase activity
CPF11_07910	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CPF11_07915	COG0590	tRNA wobble adenosine to inosine editing
CPF11_07925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPF11_07935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CPF11_08010	COG0495	leucyl-tRNA aminoacylation
CPF11_08035	COG1194	a g-specific adenine glycosylase
CPF11_08040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CPF11_08050	COG1132	(ABC) transporter
CPF11_08060	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CPF11_08065	COG0154	amidase activity
CPF11_08070	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CPF11_08075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CPF11_08085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CPF11_08135	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CPF11_08140	COG2814	Major facilitator Superfamily
CPF11_08145	COG0439	Biotin carboxylase
CPF11_08150	COG0511	ligase activity, forming carbon-carbon bonds
CPF11_08155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CPF11_08165	COG1295	ribonuclease BN
CPF11_08185	COG4133	protoheme IX ABC transporter activity
CPF11_08195	COG1126	abc transporter atp-binding protein
CPF11_08200	COG0765	amino acid transport
CPF11_08215	COG0542	response to heat
CPF11_08225	COG0779	Required for maturation of 30S ribosomal subunits
CPF11_08240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CPF11_08245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CPF11_08250	COG1522	sequence-specific DNA binding
CPF11_08255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CPF11_08260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CPF11_08275	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CPF11_08275	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CPF11_08290	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CPF11_08305	COG0489	protein tyrosine kinase activity
CPF11_08340	COG0129	dihydroxy-acid dehydratase activity
CPF11_08345	COG0573	inorganic phosphate transmembrane transporter activity
CPF11_08350	COG0581	inorganic phosphate transmembrane transporter activity
CPF11_08355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CPF11_08360	COG0704	Plays a role in the regulation of phosphate uptake
CPF11_08375	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CPF11_08380	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CPF11_08395	COG0513	Belongs to the DEAD box helicase family
CPF11_08405	COG0346	lactoylglutathione lyase activity
CPF11_08410	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CPF11_08415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CPF11_08420	COG0552	protein localization to endoplasmic reticulum
CPF11_08430	COG0356	it plays a direct role in the translocation of protons across the membrane
CPF11_08435	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CPF11_08440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CPF11_08445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CPF11_08450	COG0463	Glycosyl transferase, family 2
CPF11_08455	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CPF11_08465	COG2995	paraquat-inducible protein a
CPF11_08470	COG3008	intermembrane lipid transfer
CPF11_08480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CPF11_08495	COG1410	methionine synthase
CPF11_08495	COG0646	methionine synthase
CPF11_08505	COG2274	protein secretion by the type I secretion system
CPF11_08540	COG3008	intermembrane lipid transfer
CPF11_08540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CPF11_08545	COG1127	ABC transporter
CPF11_08550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CPF11_08555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CPF11_08560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CPF11_08565	COG1185	polyribonucleotide nucleotidyltransferase activity
CPF11_08580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CPF11_08585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CPF11_08590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CPF11_08600	COG0583	DNA-binding transcription factor activity
CPF11_08610	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CPF11_08615	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CPF11_08620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CPF11_08625	COG0509	glycine decarboxylation via glycine cleavage system
CPF11_08630	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CPF11_08630	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CPF11_08650	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CPF11_08660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPF11_08715	COG4774	siderophore transport
CPF11_08745	COG4974	Belongs to the 'phage' integrase family
CPF11_08755	COG1846	Transcriptional regulator
CPF11_08760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CPF11_08765	COG2080	2 iron, 2 sulfur cluster binding
CPF11_08770	COG2010	Cytochrome c
CPF11_08770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CPF11_08775	COG2309	aminopeptidase activity
CPF11_08780	COG1335	isochorismatase
CPF11_08785	COG0596	Alpha beta hydrolase
CPF11_08790	COG3473	Maleate cis-trans isomerase
CPF11_08795	COG2271	Major facilitator Superfamily
CPF11_08805	COG0583	DNA-binding transcription factor activity
CPF11_08850	COG0450	alkyl hydroperoxide reductase
CPF11_08855	COG0640	Transcriptional regulator
CPF11_08860	COG2818	Glycosylase
CPF11_08870	COG1393	Belongs to the ArsC family
CPF11_08895	COG3961	Belongs to the TPP enzyme family
CPF11_08900	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CPF11_08905	COG0829	nickel cation binding
CPF11_08910	COG0831	urea catabolic process
CPF11_08915	COG0832	Belongs to the urease beta subunit family
CPF11_08920	COG0804	urea catabolic process
CPF11_08925	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CPF11_08930	COG0830	nickel cation binding
CPF11_08935	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CPF11_08950	COG0745	RESPONSE REGULATOR receiver
CPF11_08955	COG2198	Histidine kinase
CPF11_08955	COG5002	protein histidine kinase activity
CPF11_08955	COG0784	Response regulator, receiver
CPF11_08965	COG0559	Belongs to the binding-protein-dependent transport system permease family
CPF11_08975	COG0411	ABC transporter
CPF11_08980	COG0410	ABC transporter
CPF11_08995	COG2814	Major facilitator Superfamily
CPF11_09005	COG0583	DNA-binding transcription factor activity
CPF11_09030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CPF11_09035	COG3158	transport of potassium into the cell
CPF11_09045	COG1063	alcohol dehydrogenase
CPF11_09070	COG3265	gluconokinase activity
CPF11_09075	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CPF11_09080	COG0363	glucosamine-6-phosphate deaminase activity
CPF11_09090	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CPF11_09095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CPF11_09110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CPF11_09125	COG1742	UPF0060 membrane protein
CPF11_09160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CPF11_09180	COG1196	nuclear chromosome segregation
CPF11_09180	COG0741	lytic transglycosylase activity
CPF11_09180	COG0739	heme binding
CPF11_09185	COG2814	Major facilitator Superfamily
CPF11_09270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CPF11_09270	COG0519	Catalyzes the synthesis of GMP from XMP
CPF11_09290	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CPF11_09305	COG0735	belongs to the Fur family
CPF11_09320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPF11_09325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CPF11_09330	COG1024	Enoyl-CoA hydratase
CPF11_09335	COG1584	GPR1 FUN34 yaaH family protein
CPF11_09340	COG1289	transmembrane transporter activity
CPF11_09365	COG1797	cobyrinic acid a,c-diamide synthase activity
CPF11_09380	COG1492	cobalamin metabolic process
CPF11_09385	COG0778	Nitroreductase
CPF11_09400	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CPF11_09405	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CPF11_09415	COG2814	Major facilitator Superfamily
CPF11_09450	COG1301	dicarboxylic acid transport
CPF11_09470	COG0848	biopolymer transport protein
CPF11_09540	COG2336	PFAM SpoVT AbrB
CPF11_09545	COG2337	Toxic component of a toxin-antitoxin (TA) module
CPF11_09580	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CPF11_09585	COG0732	type I restriction modification DNA specificity domain
CPF11_09590	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
CPF11_09600	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CPF11_09665	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CPF11_09695	COG1648	precorrin-2 dehydrogenase activity
CPF11_09695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CPF11_09700	COG0277	FAD linked oxidase domain protein
CPF11_09710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CPF11_09715	COG2011	ABC-type metal ion transport system permease component
CPF11_09725	COG3620	sequence-specific DNA binding
CPF11_09735	COG3145	DNA-N1-methyladenine dioxygenase activity
CPF11_09760	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CPF11_09770	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CPF11_09775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CPF11_09785	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CPF11_09795	COG0284	orotidine-5'-phosphate decarboxylase activity
CPF11_09800	COG0135	phosphoribosylanthranilate isomerase activity
CPF11_09825	COG1113	amino acid transport
CPF11_09840	COG1271	oxidase subunit
CPF11_09845	COG1294	oxidase, subunit
CPF11_09860	COG0477	Major facilitator Superfamily
CPF11_09875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CPF11_09875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CPF11_09880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CPF11_09885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CPF11_09890	COG1120	ATPase activity
CPF11_09895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPF11_09900	COG0564	pseudouridine synthase activity
CPF11_09905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CPF11_09915	COG1494	fructose-1,6-bisphosphatase
CPF11_09925	COG0436	Aminotransferase
CPF11_09935	COG0740	serine-type endopeptidase activity
CPF11_09945	COG0535	radical SAM domain protein
CPF11_09955	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CPF11_09960	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CPF11_09985	COG0708	Exodeoxyribonuclease III
CPF11_09990	COG0316	Belongs to the HesB IscA family
CPF11_09995	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CPF11_10000	COG0018	arginyl-trna synthetase
CPF11_10010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CPF11_10015	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CPF11_10020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CPF11_10025	COG0805	protein transport
CPF11_10030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CPF11_10040	COG4232	protein-disulfide reductase activity
CPF11_10065	COG1289	transmembrane transporter activity
CPF11_10070	COG0583	DNA-binding transcription factor activity
CPF11_10140	COG0583	DNA-binding transcription factor activity
CPF11_10150	COG0431	NADPH-dependent FMN reductase
CPF11_10160	COG2814	Major facilitator Superfamily
CPF11_10165	COG1012	belongs to the aldehyde dehydrogenase family
CPF11_10175	COG1252	NADH dehydrogenase
CPF11_10180	COG1309	transcriptional regulator
CPF11_10205	COG2308	Evidence 4 Homologs of previously reported genes of
CPF11_10220	COG0277	FAD linked oxidase domain protein
CPF11_10250	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CPF11_10260	COG0424	maF-like protein
CPF11_10265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CPF11_10270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CPF11_10275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CPF11_10280	COG1530	ribonuclease E activity
CPF11_10330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CPF11_10335	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CPF11_10340	COG0328	RNA-DNA hybrid ribonuclease activity
CPF11_10375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CPF11_10380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CPF11_10395	COG0745	RESPONSE REGULATOR receiver
CPF11_10405	COG0488	(ABC) transporter
CPF11_10410	COG0105	UTP biosynthetic process
CPF11_10415	COG1032	radical SAM domain protein
CPF11_10420	COG3161	chorismate lyase activity
CPF11_10440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CPF11_10465	COG0251	oxidation-reduction process
CPF11_10470	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CPF11_10475	COG0587	DNA-directed DNA polymerase activity
CPF11_10480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CPF11_10505	COG0052	Belongs to the universal ribosomal protein uS2 family
CPF11_10510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CPF11_10515	COG1381	Involved in DNA repair and RecF pathway recombination
CPF11_10520	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CPF11_10525	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CPF11_10530	COG0113	porphobilinogen synthase activity
CPF11_10535	COG0531	amino acid
CPF11_10540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CPF11_10560	COG0513	Belongs to the DEAD box helicase family
CPF11_10575	COG0560	Phosphoserine phosphatase
CPF11_10580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CPF11_10585	COG0028	Belongs to the TPP enzyme family
CPF11_10595	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CPF11_10605	COG2132	Multicopper oxidase
CPF11_10615	COG2217	Heavy metal translocating P-type atpase
CPF11_10625	COG1335	isochorismatase
CPF11_10630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CPF11_10645	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CPF11_10665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CPF11_10670	COG0574	Belongs to the PEP-utilizing enzyme family
CPF11_10670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CPF11_10675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CPF11_10680	COG0497	DNA recombination
CPF11_10685	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CPF11_10690	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CPF11_10700	COG0849	cell division
CPF11_10705	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CPF11_10710	COG1181	Belongs to the D-alanine--D-alanine ligase family
CPF11_10715	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CPF11_10720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CPF11_10725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CPF11_10735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CPF11_10740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CPF11_10750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CPF11_10765	COG0275	rRNA processing
CPF11_10770	COG2001	Belongs to the MraZ family
CPF11_10790	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CPF11_10795	COG3750	Belongs to the UPF0335 family
CPF11_10805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CPF11_10810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CPF11_10815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CPF11_10820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CPF11_10850	COG2826	transposase and inactivated derivatives, IS30 family
CPF11_10930	COG4372	Transposase
CPF11_10940	COG2963	transposase activity
CPF11_10990	COG2026	Addiction module toxin, RelE StbE family
CPF11_11085	COG2252	PERMEase
CPF11_11105	COG0723	plastoquinol--plastocyanin reductase activity
CPF11_11110	COG2857	Cytochrome c1
CPF11_11110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CPF11_11115	COG2857	Cytochrome c1
CPF11_11115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CPF11_11125	COG0307	riboflavin synthase, alpha
CPF11_11130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CPF11_11130	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CPF11_11135	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CPF11_11165	COG1566	PFAM secretion protein HlyD family protein
CPF11_11195	COG0521	Mo-molybdopterin cofactor biosynthetic process
CPF11_11205	COG0302	gtp cyclohydrolase
CPF11_11225	COG0494	nUDIX hydrolase
CPF11_11250	COG4974	Belongs to the 'phage' integrase family
CPF11_11270	COG0004	ammonium transporteR
CPF11_11330	COG0459	protein refolding
CPF11_11335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CPF11_11340	COG0412	Dienelactone hydrolase
CPF11_11345	COG1278	Cold shock
CPF11_11350	COG1199	ATP-dependent helicase activity
CPF11_11355	COG0483	inositol monophosphate 1-phosphatase activity
CPF11_11360	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CPF11_11370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CPF11_11375	COG0586	Pfam SNARE associated Golgi protein
CPF11_11380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CPF11_11390	COG0347	Belongs to the P(II) protein family
CPF11_11395	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CPF11_11410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CPF11_11420	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CPF11_11520	COG0463	Glycosyl transferase, family 2
CPF11_11525	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CPF11_11525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CPF11_11550	COG2204	response regulator
CPF11_11555	COG1923	regulation of RNA biosynthetic process
CPF11_11560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CPF11_11565	COG1051	belongs to the nudix hydrolase family
CPF11_11575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CPF11_11600	COG0659	secondary active sulfate transmembrane transporter activity
CPF11_11605	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CPF11_11610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CPF11_11615	COG0354	folic acid binding
CPF11_11620	COG0367	asparagine synthase
CPF11_11625	COG0438	transferase activity, transferring glycosyl groups
CPF11_11650	COG1160	GTP binding
CPF11_11655	COG2814	Major facilitator Superfamily
CPF11_11660	COG3572	ergothioneine biosynthetic process
CPF11_11670	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CPF11_11680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CPF11_11685	COG0564	pseudouridine synthase activity
CPF11_11710	COG0228	four-way junction DNA binding
CPF11_11715	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CPF11_11720	COG0336	Belongs to the RNA methyltransferase TrmD family
CPF11_11725	COG0335	large ribosomal subunit rRNA binding
CPF11_11730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CPF11_11735	COG0066	3-isopropylmalate dehydratase activity
CPF11_11740	COG0473	3-isopropylmalate dehydrogenase activity
CPF11_11745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CPF11_11750	COG0242	peptide deformylase activity
CPF11_11760	COG1846	Transcriptional regulator
CPF11_11765	COG0745	RESPONSE REGULATOR receiver
CPF11_11770	COG2205	protein histidine kinase activity
CPF11_11785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CPF11_11790	COG0416	fatty acid biosynthetic process
CPF11_11795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CPF11_11800	COG0776	regulation of translation
CPF11_11830	COG0776	regulation of translation
CPF11_11835	COG4957	zinc ion binding
CPF11_11840	COG0583	DNA-binding transcription factor activity
CPF11_11845	COG0492	ferredoxin-NADP+ reductase activity
CPF11_11850	COG1522	sequence-specific DNA binding
CPF11_11855	COG0463	Glycosyl transferase, family 2
CPF11_11875	COG2226	methyltransferase
CPF11_11885	COG0109	protoheme IX farnesyltransferase activity
CPF11_11900	COG0312	modulator of DNA gyrase
CPF11_11905	COG0612	Peptidase, M16
CPF11_11930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CPF11_11935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CPF11_11945	COG5265	(ABC) transporter
CPF11_11955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CPF11_11960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CPF11_11970	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CPF11_11975	COG2733	membrane
CPF11_11985	COG0719	Fe-S assembly protein
CPF11_11990	COG0396	ATPase activity
CPF11_11995	COG0719	Fe-S assembly protein
CPF11_12000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CPF11_12010	COG2151	metal-sulfur cluster biosynthetic enzyme
CPF11_12015	COG0316	Belongs to the HesB IscA family
CPF11_12020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CPF11_12025	COG0513	Belongs to the DEAD box helicase family
CPF11_12035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CPF11_12035	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CPF11_12045	COG0544	peptidyl-prolyl cis-trans isomerase activity
CPF11_12050	COG0740	serine-type endopeptidase activity
CPF11_12055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CPF11_12065	COG0776	regulation of translation
CPF11_12080	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CPF11_12085	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CPF11_12090	COG0649	NAD binding
CPF11_12095	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CPF11_12105	COG1034	ATP synthesis coupled electron transport
CPF11_12110	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CPF11_12115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CPF11_12125	COG0713	ATP synthesis coupled electron transport
CPF11_12135	COG1007	ATP synthesis coupled electron transport
CPF11_12145	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CPF11_12155	COG0442	prolyl-tRNA aminoacylation
CPF11_12165	COG1136	(ABC) transporter
CPF11_12170	COG0386	Belongs to the glutathione peroxidase family
CPF11_12185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CPF11_12190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CPF11_12195	COG0546	phosphoglycolate phosphatase activity
CPF11_12220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CPF11_12235	COG0156	8-amino-7-oxononanoate synthase activity
CPF11_12245	COG0318	PFAM AMP-dependent synthetase and ligase
CPF11_12300	COG4221	oxidoreductase activity
CPF11_12305	COG2315	Protein conserved in bacteria
CPF11_12325	COG0789	Transcriptional regulator
CPF11_12330	COG1028	Short-chain dehydrogenase reductase Sdr
CPF11_12345	COG1538	Outer membrane efflux protein
CPF11_12360	COG0583	DNA-binding transcription factor activity
CPF11_12370	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CPF11_12410	COG1902	pentaerythritol trinitrate reductase activity
CPF11_12425	COG2814	Major facilitator Superfamily
CPF11_12440	COG1064	alcohol dehydrogenase
CPF11_12455	COG0488	(ABC) transporter
CPF11_12470	COG2985	domain, Protein
CPF11_12480	COG0252	asparaginase activity
CPF11_12495	COG4774	siderophore transport
CPF11_12500	COG3128	pkhd-type hydroxylase
CPF11_12505	COG4988	ABC transporter
CPF11_12510	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CPF11_12515	COG1271	oxidase subunit
CPF11_12520	COG1294	oxidase, subunit
CPF11_12535	COG0668	transmembrane transport
CPF11_12550	COG1032	radical SAM domain protein
CPF11_12560	COG1695	Transcriptional regulator
CPF11_12580	COG3511	phospholipase C
CPF11_12590	COG0671	phosphoesterase, PA-phosphatase related
CPF11_12595	COG2070	2-Nitropropane dioxygenase
CPF11_12600	COG4608	Belongs to the ABC transporter superfamily
CPF11_12620	COG0747	negative chemotaxis
CPF11_12630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CPF11_12630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CPF11_12645	COG0745	RESPONSE REGULATOR receiver
CPF11_12660	COG0180	Tryptophanyl-tRNA synthetase
CPF11_12670	COG0545	Peptidyl-prolyl cis-trans isomerase
CPF11_12675	COG0137	argininosuccinate synthase activity
CPF11_12680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CPF11_12690	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CPF11_12695	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CPF11_12700	COG0142	geranyltranstransferase activity
CPF11_12705	COG1722	exodeoxyribonuclease VII activity
CPF11_12710	COG0425	Belongs to the sulfur carrier protein TusA family
CPF11_12715	COG1940	carbohydrate kinase activity
CPF11_12720	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CPF11_12725	COG0248	Ppx GppA phosphatase
CPF11_12735	COG3383	formate dehydrogenase (NAD+) activity
CPF11_12735	COG0243	molybdopterin cofactor binding
CPF11_12740	COG0437	4 iron, 4 sulfur cluster binding
CPF11_12745	COG2864	formate dehydrogenase
CPF11_12750	COG3058	Necessary for formate dehydrogenase activity
CPF11_12755	COG0303	'Molybdopterin
CPF11_12760	COG1763	Mo-molybdopterin cofactor biosynthetic process
CPF11_12765	COG0746	molybdenum cofactor guanylyltransferase activity
CPF11_12770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CPF11_12780	COG1971	Probably functions as a manganese efflux pump
CPF11_12790	COG0493	'glutamate synthase
CPF11_12795	COG0674	pyruvate-flavodoxin oxidoreductase activity
CPF11_12795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CPF11_12795	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CPF11_12795	COG1013	pyruvate-flavodoxin oxidoreductase activity
CPF11_12800	COG0167	dihydroorotate dehydrogenase activity
CPF11_12820	COG0628	permease
CPF11_12875	COG0114	fumarate hydratase activity
CPF11_12925	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CPF11_12930	COG2814	Major facilitator Superfamily
CPF11_12935	COG2999	glutathione oxidoreductase activity
CPF11_12940	COG0500	methyltransferase
CPF11_12945	COG1301	dicarboxylic acid transport
CPF11_13030	COG0587	DNA-directed DNA polymerase activity
CPF11_13035	COG0625	glutathione transferase activity
CPF11_13075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CPF11_13100	COG4372	Transposase
CPF11_13160	COG5489	Protein of unknown function (DUF736)
CPF11_13215	COG0741	lytic transglycosylase activity
CPF11_13280	COG1309	transcriptional regulator
CPF11_13295	COG1764	response to oxidative stress
CPF11_13300	COG2130	NADP-dependent
CPF11_13305	COG1309	transcriptional regulator
CPF11_13310	COG1012	belongs to the aldehyde dehydrogenase family
CPF11_13335	COG0655	NAD(P)H dehydrogenase (quinone) activity
CPF11_13360	COG1538	Outer membrane efflux protein
CPF11_13370	COG0583	DNA-binding transcription factor activity
CPF11_13410	COG4974	Belongs to the 'phage' integrase family
CPF11_13480	COG1959	2 iron, 2 sulfur cluster binding
CPF11_13485	COG1017	nitric oxide dioxygenase activity
CPF11_13485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CPF11_13490	COG3256	nitric oxide reductase
CPF11_13495	COG3189	MarR family transcriptional regulator
CPF11_13525	COG4372	Transposase
CPF11_13535	COG2963	transposase activity
CPF11_13550	COG2026	Addiction module toxin, RelE StbE family
CPF11_13555	COG3077	Addiction module antitoxin, RelB DinJ family
CPF11_13560	COG1902	pentaerythritol trinitrate reductase activity
CPF11_13655	COG0745	RESPONSE REGULATOR receiver
CPF11_13660	COG0642	Histidine kinase
CPF11_13670	COG2223	nitrite transmembrane transporter activity
CPF11_13680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CPF11_13680	COG2146	nitrite reductase [NAD(P)H] activity
CPF11_13700	COG2072	flavoprotein involved in K transport
CPF11_13705	COG1012	belongs to the aldehyde dehydrogenase family
CPF11_13715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CPF11_13790	COG1294	oxidase, subunit
CPF11_13795	COG1271	oxidase subunit
CPF11_13825	COG2336	PFAM SpoVT AbrB
CPF11_13830	COG2337	Toxic component of a toxin-antitoxin (TA) module
CPF11_13945	COG3189	MarR family transcriptional regulator
CPF11_14005	COG1309	transcriptional regulator
CPF11_14010	COG1979	alcohol dehydrogenase
CPF11_14015	COG1012	belongs to the aldehyde dehydrogenase family
CPF11_14040	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
CPF11_14050	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CPF11_14065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CPF11_14070	COG0431	NADPH-dependent FMN reductase
CPF11_14075	COG2072	flavoprotein involved in K transport
CPF11_14080	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
CPF11_14135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CPF11_14175	COG4115	mRNA cleavage
CPF11_14180	COG2161	toxin-antitoxin pair type II binding
CPF11_14200	COG1487	ribonuclease activity
CPF11_14260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs