locus-tag	class	description
CIW82_00015	COG0789	Transcriptional regulator
CIW82_00035	COG1914	H( )-stimulated, divalent metal cation uptake system
CIW82_00040	COG1321	iron dependent repressor
CIW82_00070	COG2207	Transcriptional regulator
CIW82_00080	COG3328	transposase activity
CIW82_00090	COG2814	Major facilitator Superfamily
CIW82_00105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CIW82_00110	COG0765	amino acid transport
CIW82_00125	COG0402	S-adenosylhomocysteine deaminase activity
CIW82_00130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CIW82_00140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CIW82_00150	COG0251	oxidation-reduction process
CIW82_00190	COG2826	transposase and inactivated derivatives, IS30 family
CIW82_00215	COG0183	Belongs to the thiolase family
CIW82_00230	COG1960	acyl-CoA dehydrogenase activity
CIW82_00235	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIW82_00235	COG1024	Enoyl-CoA hydratase
CIW82_00245	COG1309	transcriptional regulator
CIW82_00250	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CIW82_00250	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CIW82_00265	COG3436	PFAM IS66 Orf2 family protein
CIW82_00295	COG3511	phospholipase C
CIW82_00315	COG4302	ethanolamine ammonia-lyase activity
CIW82_00330	COG2932	Transcriptional regulator
CIW82_00355	COG2801	Transposase and inactivated derivatives
CIW82_00360	COG2842	Transposition protein
CIW82_00455	COG4373	Mu-like prophage FluMu protein gp28
CIW82_00495	COG4397	Mu-like prophage major head subunit gpT
CIW82_00565	COG3778	Protein conserved in bacteria
CIW82_00625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIW82_00630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW82_00640	COG1522	sequence-specific DNA binding
CIW82_00645	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CIW82_00650	COG1473	amidohydrolase
CIW82_00655	COG1473	amidohydrolase
CIW82_00675	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CIW82_00680	COG2843	Capsule synthesis protein
CIW82_00715	COG2271	Major facilitator Superfamily
CIW82_00720	COG0154	amidase activity
CIW82_00725	COG1473	amidohydrolase
CIW82_00730	COG2610	gluconate transmembrane transporter activity
CIW82_00735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CIW82_00740	COG0251	oxidation-reduction process
CIW82_00780	COG3511	phospholipase C
CIW82_00800	COG1834	amidinotransferase
CIW82_00815	COG1126	abc transporter atp-binding protein
CIW82_00840	COG4771	TonB-dependent receptor
CIW82_00855	COG4774	siderophore transport
CIW82_00860	COG3128	pkhd-type hydroxylase
CIW82_00880	COG1215	transferase activity, transferring glycosyl groups
CIW82_00895	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CIW82_00905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CIW82_00915	COG4310	Domain of unknown function (DUF2172)
CIW82_00935	COG0438	transferase activity, transferring glycosyl groups
CIW82_00955	COG3206	protein involved in exopolysaccharide biosynthesis
CIW82_00955	COG0489	protein tyrosine kinase activity
CIW82_00970	COG0438	transferase activity, transferring glycosyl groups
CIW82_00975	COG1215	transferase activity, transferring glycosyl groups
CIW82_00990	COG0025	NhaP-type Na H and K H
CIW82_01020	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CIW82_01020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CIW82_01020	COG1013	pyruvate-flavodoxin oxidoreductase activity
CIW82_01020	COG0674	pyruvate-flavodoxin oxidoreductase activity
CIW82_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIW82_01050	COG4206	TonB-dependent receptor
CIW82_01055	COG0523	cobalamin synthesis protein
CIW82_01065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CIW82_01090	COG2132	Multicopper oxidase
CIW82_01105	COG1937	Protein conserved in bacteria
CIW82_01110	COG2217	Heavy metal translocating P-type atpase
CIW82_01155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIW82_01165	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CIW82_01185	COG1678	Uncharacterized ACR, COG1678
CIW82_01190	COG2326	polyphosphate kinase activity
CIW82_01205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CIW82_01210	COG1686	Belongs to the peptidase S11 family
CIW82_01215	COG0024	Methionine aminopeptidase
CIW82_01225	COG1683	Conserved Protein
CIW82_01230	COG1509	lysine 2,3-aminomutase activity
CIW82_01255	COG0352	thiamine-phosphate diphosphorylase activity
CIW82_01260	COG1830	Aldolase
CIW82_01285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CIW82_01290	COG1692	metallophosphoesterase
CIW82_01300	COG0167	dihydroorotate dehydrogenase activity
CIW82_01310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CIW82_01325	COG1215	transferase activity, transferring glycosyl groups
CIW82_01330	COG0612	Peptidase, M16
CIW82_01345	COG0628	permease
CIW82_01350	COG0556	nucleotide-excision repair
CIW82_01360	COG0667	Aldo Keto reductase
CIW82_01370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CIW82_01375	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CIW82_01380	COG1877	trehalose-phosphatase activity
CIW82_01405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CIW82_01420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CIW82_01435	COG1881	PFAM PEBP family protein
CIW82_01445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CIW82_01450	COG0343	queuine tRNA-ribosyltransferase activity
CIW82_01455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CIW82_01475	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CIW82_01500	COG0488	(ABC) transporter
CIW82_01510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CIW82_01530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CIW82_01535	COG0450	alkyl hydroperoxide reductase
CIW82_01545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CIW82_01555	COG0287	Prephenate dehydrogenase
CIW82_01565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIW82_01575	COG1562	ergosterol biosynthetic process
CIW82_01580	COG1562	ergosterol biosynthetic process
CIW82_01585	COG1233	COG1233 Phytoene dehydrogenase and related
CIW82_01590	COG1657	PFAM Prenyltransferase squalene oxidase
CIW82_01600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CIW82_01605	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CIW82_01610	COG1231	oxidoreductase activity
CIW82_01615	COG2010	Cytochrome c
CIW82_01635	COG1566	PFAM secretion protein HlyD family protein
CIW82_01645	COG1846	Transcriptional regulator
CIW82_01660	COG3842	ATPase activity
CIW82_01675	COG2983	Belongs to the UPF0260 family
CIW82_01705	COG0517	IMP dehydrogenase activity
CIW82_01710	COG4974	Belongs to the 'phage' integrase family
CIW82_01725	COG2337	Toxic component of a toxin-antitoxin (TA) module
CIW82_01730	COG2336	PFAM SpoVT AbrB
CIW82_01815	COG1012	belongs to the aldehyde dehydrogenase family
CIW82_01820	COG1252	NADH dehydrogenase
CIW82_01835	COG1309	transcriptional regulator
CIW82_01875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIW82_01885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIW82_01905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIW82_01925	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CIW82_01955	COG1942	4-Oxalocrotonate Tautomerase
CIW82_01965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIW82_02005	COG4993	Dehydrogenase
CIW82_02025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CIW82_02065	COG3585	molybdate ion transport
CIW82_02075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CIW82_02085	COG1573	uracil-dna glycosylase
CIW82_02090	COG0741	lytic transglycosylase activity
CIW82_02105	COG2308	Evidence 4 Homologs of previously reported genes of
CIW82_02120	COG1253	flavin adenine dinucleotide binding
CIW82_02125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CIW82_02130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CIW82_02145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIW82_02150	COG3394	polysaccharide catabolic process
CIW82_02170	COG0717	Belongs to the dCTP deaminase family
CIW82_02175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CIW82_02190	COG1139	Iron-sulfur cluster binding protein
CIW82_02195	COG0247	lactate metabolic process
CIW82_02225	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CIW82_02230	COG0799	negative regulation of ribosome biogenesis
CIW82_02235	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CIW82_02240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CIW82_02245	COG0012	GTP binding
CIW82_02250	COG0193	aminoacyl-tRNA hydrolase activity
CIW82_02255	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CIW82_02265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CIW82_02280	COG2309	aminopeptidase activity
CIW82_02300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CIW82_02325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CIW82_02330	COG0154	amidase activity
CIW82_02335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CIW82_02340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CIW82_02355	COG1584	GPR1 FUN34 yaaH family protein
CIW82_02380	COG3042	response to heat
CIW82_02385	COG0326	Molecular chaperone. Has ATPase activity
CIW82_02390	COG1414	Transcriptional regulator
CIW82_02400	COG2814	Major facilitator Superfamily
CIW82_02405	COG3956	TIGRFAM MazG family protein
CIW82_02410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CIW82_02415	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_02420	COG0604	alcohol dehydrogenase
CIW82_02430	COG1253	flavin adenine dinucleotide binding
CIW82_02445	COG0746	molybdenum cofactor guanylyltransferase activity
CIW82_02450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CIW82_02460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CIW82_02480	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CIW82_02485	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CIW82_02500	COG0159	tryptophan synthase activity
CIW82_02505	COG0133	tryptophan synthase activity
CIW82_02520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CIW82_02540	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CIW82_02545	COG1396	sequence-specific DNA binding
CIW82_02555	COG0752	glycyl-tRNA synthetase alpha subunit
CIW82_02570	COG5487	UPF0391 membrane protein
CIW82_02580	COG0138	bifunctional purine biosynthesis protein purh
CIW82_02585	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CIW82_02590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CIW82_02595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CIW82_02600	COG0484	heat shock protein binding
CIW82_02605	COG0443	Heat shock 70 kDa protein
CIW82_02610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CIW82_02615	COG0745	RESPONSE REGULATOR receiver
CIW82_02620	COG2205	protein histidine kinase activity
CIW82_02630	COG1660	Displays ATPase and GTPase activities
CIW82_02640	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CIW82_02670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CIW82_02675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIW82_02690	COG4771	TonB-dependent receptor
CIW82_02700	COG1289	transmembrane transporter activity
CIW82_02720	COG3128	pkhd-type hydroxylase
CIW82_02730	COG1393	Belongs to the ArsC family
CIW82_02740	COG1566	PFAM secretion protein HlyD family protein
CIW82_02745	COG1289	transmembrane transporter activity
CIW82_02755	COG0625	glutathione transferase activity
CIW82_02760	COG2818	Glycosylase
CIW82_02790	COG0583	DNA-binding transcription factor activity
CIW82_02795	COG0477	Major facilitator Superfamily
CIW82_02800	COG4977	sequence-specific DNA binding
CIW82_02810	COG1032	radical SAM domain protein
CIW82_02880	COG4771	TonB-dependent receptor
CIW82_02885	COG1132	(ABC) transporter
CIW82_02895	COG1917	Cupin 2, conserved barrel domain protein
CIW82_02895	COG2207	Transcriptional regulator
CIW82_02905	COG4774	siderophore transport
CIW82_02960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CIW82_02965	COG0583	DNA-binding transcription factor activity
CIW82_03010	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_03025	COG1522	sequence-specific DNA binding
CIW82_03030	COG1280	lysine exporter protein (LysE YggA)
CIW82_03035	COG0583	DNA-binding transcription factor activity
CIW82_03040	COG0679	Auxin Efflux Carrier
CIW82_03045	COG0583	DNA-binding transcription factor activity
CIW82_03050	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_03060	COG2072	flavoprotein involved in K transport
CIW82_03075	COG2144	transferase activity, transferring acyl groups
CIW82_03100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIW82_03105	COG2084	Dehydrogenase
CIW82_03110	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_03125	COG0583	DNA-binding transcription factor activity
CIW82_03140	COG1309	transcriptional regulator
CIW82_03150	COG0667	Aldo Keto reductase
CIW82_03155	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_03165	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_03175	COG2814	Major facilitator Superfamily
CIW82_03185	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_03205	COG0300	oxidoreductase activity
CIW82_03210	COG2207	Transcriptional regulator
CIW82_03250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIW82_03285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CIW82_03290	COG0587	DNA-directed DNA polymerase activity
CIW82_03295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIW82_03410	COG2086	electron transfer activity
CIW82_03425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIW82_03435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CIW82_03455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CIW82_03460	COG0590	tRNA wobble adenosine to inosine editing
CIW82_03465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CIW82_03470	COG1187	pseudouridine synthase activity
CIW82_03475	COG0742	ribosomal rna small subunit methyltransferase
CIW82_03480	COG0629	single-stranded DNA binding
CIW82_03490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CIW82_03505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CIW82_03510	COG0312	modulator of DNA gyrase
CIW82_03545	COG1091	dTDP-4-dehydrorhamnose reductase activity
CIW82_03555	COG1674	ftsk spoiiie
CIW82_03575	COG0482	sulfurtransferase activity
CIW82_03585	COG1104	cysteine desulfurase activity
CIW82_03590	COG1104	cysteine desulfurase activity
CIW82_03600	COG2945	thiolester hydrolase activity
CIW82_03610	COG0215	cysteine-tRNA ligase activity
CIW82_03620	COG0285	dihydrofolate synthase activity
CIW82_03625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CIW82_03635	COG1074	ATP-dependent DNA helicase activity
CIW82_03640	COG2887	Belongs to the helicase family. UvrD subfamily
CIW82_03645	COG0802	atpase or kinase
CIW82_03650	COG0745	RESPONSE REGULATOR receiver
CIW82_03655	COG0351	phosphomethylpyrimidine kinase
CIW82_03655	COG0352	thiamine-phosphate diphosphorylase activity
CIW82_03660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIW82_03670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CIW82_03675	COG0037	tRNA processing
CIW82_03685	COG2885	chlorophyll binding
CIW82_03690	COG0823	Involved in the tonB-independent uptake of proteins
CIW82_03700	COG0848	biopolymer transport protein
CIW82_03710	COG0824	Thioesterase
CIW82_03715	COG2255	four-way junction helicase activity
CIW82_03720	COG0632	four-way junction helicase activity
CIW82_03725	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CIW82_03730	COG0217	transcriptional regulatory protein
CIW82_03735	COG0653	protein targeting
CIW82_03740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CIW82_03745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CIW82_03750	COG1714	RDD family
CIW82_03755	COG0668	transmembrane transport
CIW82_03775	COG0484	heat shock protein binding
CIW82_03820	COG2079	MmgE PrpD family protein
CIW82_03830	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CIW82_03840	COG0776	regulation of translation
CIW82_03845	COG3754	Rhamnan synthesis protein F
CIW82_03860	COG1215	transferase activity, transferring glycosyl groups
CIW82_03875	COG0131	Imidazoleglycerol-phosphate dehydratase
CIW82_03880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CIW82_03885	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CIW82_03890	COG0107	imidazoleglycerol-phosphate synthase activity
CIW82_03895	COG0140	phosphoribosyl-ATP diphosphatase activity
CIW82_03905	COG0778	Nitroreductase
CIW82_03910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CIW82_03920	COG2826	transposase and inactivated derivatives, IS30 family
CIW82_04020	COG1475	DNA binding
CIW82_04025	COG1192	Involved in chromosome partitioning
CIW82_04030	COG0357	Ribosomal RNA small subunit methyltransferase G
CIW82_04035	COG0445	tRNA wobble uridine modification
CIW82_04040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CIW82_04050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CIW82_04090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CIW82_04095	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CIW82_04100	COG0424	maF-like protein
CIW82_04215	COG0582	viral genome integration into host DNA
CIW82_04220	COG2814	Major facilitator Superfamily
CIW82_04235	COG2835	tetraacyldisaccharide 4'-kinase activity
CIW82_04250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CIW82_04270	COG0583	DNA-binding transcription factor activity
CIW82_04295	COG0778	Nitroreductase
CIW82_04315	COG0151	Belongs to the GarS family
CIW82_04320	COG1570	exodeoxyribonuclease VII activity
CIW82_04335	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CIW82_04350	COG1012	belongs to the aldehyde dehydrogenase family
CIW82_04365	COG0246	Mannitol dehydrogenase
CIW82_04370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CIW82_04375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CIW82_04385	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CIW82_04390	COG1053	succinate dehydrogenase
CIW82_04395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CIW82_04405	COG1247	-acetyltransferase
CIW82_04420	COG0126	phosphoglycerate kinase activity
CIW82_04440	COG0156	8-amino-7-oxononanoate synthase activity
CIW82_04450	COG0405	Gamma-glutamyltransferase
CIW82_04470	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CIW82_04475	COG2943	transferase activity, transferring hexosyl groups
CIW82_04480	COG2321	neutral zinc metallopeptidase
CIW82_04485	COG0667	Aldo Keto reductase
CIW82_04490	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CIW82_04520	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CIW82_04525	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CIW82_04530	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_04535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CIW82_04545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CIW82_04550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CIW82_04555	COG0539	negative regulation of cytoplasmic translation
CIW82_04565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CIW82_04570	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CIW82_04575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CIW82_04580	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CIW82_04585	COG1420	regulation of RNA biosynthetic process
CIW82_04590	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CIW82_04630	COG1538	Outer membrane efflux protein
CIW82_04650	COG2814	Major facilitator Superfamily
CIW82_04660	COG0772	Belongs to the SEDS family
CIW82_04665	COG0768	penicillin binding
CIW82_04690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CIW82_04695	COG1612	heme a metabolic process
CIW82_04705	COG2814	Major facilitator Superfamily
CIW82_04715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CIW82_04720	COG1289	transmembrane transporter activity
CIW82_04740	COG1573	uracil-dna glycosylase
CIW82_04745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CIW82_04765	COG0670	Belongs to the BI1 family
CIW82_04785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CIW82_04805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CIW82_04820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CIW82_04840	COG4774	siderophore transport
CIW82_04850	COG0443	Heat shock 70 kDa protein
CIW82_04855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CIW82_04875	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_04880	COG0586	Pfam SNARE associated Golgi protein
CIW82_04915	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CIW82_04920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CIW82_04925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CIW82_04930	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CIW82_04935	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CIW82_04940	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CIW82_04945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CIW82_04950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIW82_04970	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CIW82_04980	COG1522	sequence-specific DNA binding
CIW82_04990	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_05010	COG1294	oxidase, subunit
CIW82_05015	COG1271	oxidase subunit
CIW82_05020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CIW82_05025	COG4988	ABC transporter
CIW82_05040	COG0450	alkyl hydroperoxide reductase
CIW82_05045	COG0640	Transcriptional regulator
CIW82_05065	COG0495	leucyl-tRNA aminoacylation
CIW82_05090	COG1194	a g-specific adenine glycosylase
CIW82_05095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CIW82_05100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CIW82_05105	COG5265	(ABC) transporter
CIW82_05125	COG0493	'glutamate synthase
CIW82_05135	COG1953	Uracil, thiamine, allantoin
CIW82_05140	COG0583	DNA-binding transcription factor activity
CIW82_05155	COG1012	belongs to the aldehyde dehydrogenase family
CIW82_05170	COG3327	negative regulation of DNA-templated transcription, initiation
CIW82_05175	COG3396	Phenylacetate-CoA oxygenase
CIW82_05180	COG3460	Phenylacetate-CoA oxygenase
CIW82_05185	COG3396	Phenylacetate-CoA oxygenase
CIW82_05190	COG2151	metal-sulfur cluster biosynthetic enzyme
CIW82_05195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CIW82_05205	COG2030	dehydratase
CIW82_05205	COG1012	belongs to the aldehyde dehydrogenase family
CIW82_05215	COG1024	Enoyl-CoA hydratase
CIW82_05220	COG0183	Belongs to the thiolase family
CIW82_05225	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIW82_05225	COG1024	Enoyl-CoA hydratase
CIW82_05260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CIW82_05265	COG1846	Transcriptional regulator
CIW82_05295	COG3971	2-oxopent-4-enoate hydratase activity
CIW82_05305	COG0477	Major facilitator Superfamily
CIW82_05315	COG1304	FMN binding
CIW82_05320	COG1012	belongs to the aldehyde dehydrogenase family
CIW82_05330	COG4771	TonB-dependent receptor
CIW82_05335	COG1960	acyl-CoA dehydrogenase activity
CIW82_05340	COG4638	Rieske (2fe-2S)
CIW82_05360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CIW82_05390	COG2814	Major facilitator Superfamily
CIW82_05395	COG0667	Aldo Keto reductase
CIW82_05405	COG1448	Aminotransferase
CIW82_05410	COG1522	sequence-specific DNA binding
CIW82_05435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIW82_05440	COG2313	pseudouridylate synthase activity
CIW82_05450	COG1957	nucleoside hydrolase
CIW82_05470	COG1177	transmembrane transport
CIW82_05475	COG1177	transmembrane transport
CIW82_05500	COG1522	sequence-specific DNA binding
CIW82_05500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIW82_05520	COG3547	Transposase (IS116 IS110 IS902 family)
CIW82_05570	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CIW82_05600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CIW82_05605	COG2072	flavoprotein involved in K transport
CIW82_05615	COG0583	DNA-binding transcription factor activity
CIW82_05625	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CIW82_05630	COG0583	DNA-binding transcription factor activity
CIW82_05660	COG3620	sequence-specific DNA binding
CIW82_05665	COG2353	YceI-like domain
CIW82_05675	COG3145	DNA-N1-methyladenine dioxygenase activity
CIW82_05700	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CIW82_05710	COG2818	Glycosylase
CIW82_05720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CIW82_05725	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CIW82_05740	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CIW82_05750	COG0284	orotidine-5'-phosphate decarboxylase activity
CIW82_05755	COG0135	phosphoribosylanthranilate isomerase activity
CIW82_05765	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CIW82_05770	COG2814	Major facilitator Superfamily
CIW82_05780	COG0439	Biotin carboxylase
CIW82_05785	COG0511	ligase activity, forming carbon-carbon bonds
CIW82_05790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CIW82_05800	COG1295	ribonuclease BN
CIW82_05805	COG0019	diaminopimelate decarboxylase activity
CIW82_05815	COG0667	Aldo Keto reductase
CIW82_05820	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CIW82_05825	COG4133	protoheme IX ABC transporter activity
CIW82_05835	COG1126	abc transporter atp-binding protein
CIW82_05850	COG0583	DNA-binding transcription factor activity
CIW82_05860	COG0542	response to heat
CIW82_05870	COG0779	Required for maturation of 30S ribosomal subunits
CIW82_05885	COG5373	membrane
CIW82_05885	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CIW82_05890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CIW82_05895	COG1522	sequence-specific DNA binding
CIW82_05900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CIW82_05905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIW82_05920	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CIW82_05920	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CIW82_05940	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CIW82_05955	COG2011	ABC-type metal ion transport system permease component
CIW82_05960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CIW82_05965	COG1464	Belongs to the NlpA lipoprotein family
CIW82_05975	COG0489	protein tyrosine kinase activity
CIW82_06020	COG0129	dihydroxy-acid dehydratase activity
CIW82_06035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CIW82_06040	COG0704	Plays a role in the regulation of phosphate uptake
CIW82_06065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CIW82_06070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CIW82_06095	COG0513	Belongs to the DEAD box helicase family
CIW82_06105	COG0346	lactoylglutathione lyase activity
CIW82_06110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CIW82_06115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIW82_06120	COG0552	protein localization to endoplasmic reticulum
CIW82_06130	COG0356	it plays a direct role in the translocation of protons across the membrane
CIW82_06135	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CIW82_06145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CIW82_06150	COG0463	Glycosyl transferase, family 2
CIW82_06155	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CIW82_06165	COG2995	paraquat-inducible protein a
CIW82_06170	COG3008	intermembrane lipid transfer
CIW82_06180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CIW82_06185	COG1286	toxin biosynthetic process
CIW82_06195	COG1283	sodium-dependent phosphate transmembrane transporter activity
CIW82_06215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW82_06235	COG0438	transferase activity, transferring glycosyl groups
CIW82_06245	COG3008	intermembrane lipid transfer
CIW82_06245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CIW82_06250	COG1127	ABC transporter
CIW82_06255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CIW82_06260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CIW82_06265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CIW82_06270	COG1185	polyribonucleotide nucleotidyltransferase activity
CIW82_06285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CIW82_06290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CIW82_06295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CIW82_06305	COG0583	DNA-binding transcription factor activity
CIW82_06320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CIW82_06330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CIW82_06335	COG0509	glycine decarboxylation via glycine cleavage system
CIW82_06340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CIW82_06340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CIW82_06350	COG0363	glucosamine-6-phosphate deaminase activity
CIW82_06355	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CIW82_06360	COG3876	Protein conserved in bacteria
CIW82_06365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CIW82_06400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CIW82_06430	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_06455	COG2814	Major facilitator Superfamily
CIW82_06460	COG0708	Exodeoxyribonuclease III
CIW82_06465	COG0316	Belongs to the HesB IscA family
CIW82_06470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CIW82_06475	COG0018	arginyl-trna synthetase
CIW82_06485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CIW82_06500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIW82_06505	COG0805	protein transport
CIW82_06510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CIW82_06525	COG0745	RESPONSE REGULATOR receiver
CIW82_06555	COG2076	Multidrug Resistance protein
CIW82_06575	COG1695	Transcriptional regulator
CIW82_06580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CIW82_06590	COG0671	phosphoesterase, PA-phosphatase related
CIW82_06600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CIW82_06745	COG0305	Participates in initiation and elongation during chromosome replication
CIW82_06945	COG2814	Major facilitator Superfamily
CIW82_06950	COG0668	transmembrane transport
CIW82_06965	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CIW82_06970	COG1120	ATPase activity
CIW82_06975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIW82_06980	COG0564	pseudouridine synthase activity
CIW82_06990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CIW82_07010	COG3328	transposase activity
CIW82_07030	COG0740	serine-type endopeptidase activity
CIW82_07040	COG0436	Aminotransferase
CIW82_07050	COG1494	fructose-1,6-bisphosphatase
CIW82_07055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CIW82_07060	COG3586	endonuclease activity
CIW82_07065	COG0242	peptide deformylase activity
CIW82_07075	COG1301	dicarboxylic acid transport
CIW82_07090	COG0535	radical SAM domain protein
CIW82_07105	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CIW82_07110	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CIW82_07180	COG1956	GAF domain-containing protein
CIW82_07325	COG0612	Peptidase, M16
CIW82_07400	COG1278	Cold shock
CIW82_07405	COG1476	TRANSCRIPTIONal
CIW82_07420	COG0754	glutathionylspermidine amidase activity
CIW82_07525	COG0753	catalase activity
CIW82_07620	COG3189	MarR family transcriptional regulator
CIW82_07625	COG1017	nitric oxide dioxygenase activity
CIW82_07625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CIW82_07630	COG1959	2 iron, 2 sulfur cluster binding
CIW82_07635	COG0306	phosphate transporter
CIW82_07640	COG1733	regulation of RNA biosynthetic process
CIW82_07655	COG3961	Belongs to the TPP enzyme family
CIW82_07665	COG0778	Nitroreductase
CIW82_07670	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CIW82_07700	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CIW82_07720	COG0584	glycerophosphoryl diester phosphodiesterase
CIW82_07745	COG4774	siderophore transport
CIW82_07790	COG0415	Belongs to the DNA photolyase family
CIW82_07800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CIW82_07830	COG0628	permease
CIW82_07855	COG4774	siderophore transport
CIW82_07880	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CIW82_07930	COG0601	transmembrane transport
CIW82_07955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CIW82_07955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CIW82_07980	COG3118	belongs to the thioredoxin family
CIW82_08030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CIW82_08065	COG1012	belongs to the aldehyde dehydrogenase family
CIW82_08235	COG0305	Participates in initiation and elongation during chromosome replication
CIW82_08425	COG2826	transposase and inactivated derivatives, IS30 family
CIW82_08465	COG0305	Participates in initiation and elongation during chromosome replication
CIW82_08495	COG4626	Terminase
CIW82_08495	COG1802	Transcriptional regulator
CIW82_08640	COG0424	maF-like protein
CIW82_08645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CIW82_08650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CIW82_08655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CIW82_08660	COG1530	ribonuclease E activity
CIW82_08720	COG3920	Histidine kinase
CIW82_08800	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CIW82_08805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CIW82_08810	COG0328	RNA-DNA hybrid ribonuclease activity
CIW82_08855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CIW82_08860	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CIW82_08875	COG0745	RESPONSE REGULATOR receiver
CIW82_08885	COG0488	(ABC) transporter
CIW82_08890	COG0105	UTP biosynthetic process
CIW82_08895	COG1032	radical SAM domain protein
CIW82_08900	COG3161	chorismate lyase activity
CIW82_08930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CIW82_08970	COG0251	oxidation-reduction process
CIW82_08975	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CIW82_08980	COG0667	Aldo Keto reductase
CIW82_08990	COG0587	DNA-directed DNA polymerase activity
CIW82_08995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CIW82_09015	COG0052	Belongs to the universal ribosomal protein uS2 family
CIW82_09020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CIW82_09025	COG1381	Involved in DNA repair and RecF pathway recombination
CIW82_09030	COG2755	lipolytic protein G-D-S-L family
CIW82_09030	COG0657	acetylesterase activity
CIW82_09035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CIW82_09040	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CIW82_09045	COG0113	porphobilinogen synthase activity
CIW82_09050	COG0531	amino acid
CIW82_09055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CIW82_09065	COG4977	sequence-specific DNA binding
CIW82_09065	COG1917	Cupin 2, conserved barrel domain protein
CIW82_09075	COG0346	lactoylglutathione lyase activity
CIW82_09080	COG0583	DNA-binding transcription factor activity
CIW82_09090	COG0431	NADPH-dependent FMN reductase
CIW82_09110	COG0513	Belongs to the DEAD box helicase family
CIW82_09125	COG4774	siderophore transport
CIW82_09135	COG0560	Phosphoserine phosphatase
CIW82_09140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CIW82_09145	COG0028	Belongs to the TPP enzyme family
CIW82_09155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CIW82_09165	COG2032	superoxide dismutase activity
CIW82_09185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CIW82_09200	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CIW82_09230	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CIW82_09235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CIW82_09235	COG0574	Belongs to the PEP-utilizing enzyme family
CIW82_09240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CIW82_09245	COG0497	DNA recombination
CIW82_09250	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CIW82_09265	COG0849	cell division
CIW82_09270	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CIW82_09275	COG1181	Belongs to the D-alanine--D-alanine ligase family
CIW82_09280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CIW82_09285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CIW82_09290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CIW82_09300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CIW82_09305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CIW82_09310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CIW82_09315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CIW82_09330	COG0275	rRNA processing
CIW82_09335	COG2001	Belongs to the MraZ family
CIW82_09355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CIW82_09370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CIW82_09375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CIW82_09380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CIW82_09385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CIW82_09400	COG1846	Transcriptional regulator
CIW82_09405	COG4774	siderophore transport
CIW82_09410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CIW82_09415	COG2080	2 iron, 2 sulfur cluster binding
CIW82_09420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CIW82_09420	COG2010	Cytochrome c
CIW82_09425	COG2309	aminopeptidase activity
CIW82_09430	COG1335	isochorismatase
CIW82_09435	COG3473	Maleate cis-trans isomerase
CIW82_09440	COG0596	Alpha beta hydrolase
CIW82_09445	COG2271	Major facilitator Superfamily
CIW82_09465	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_09470	COG2814	Major facilitator Superfamily
CIW82_09475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CIW82_09480	COG1609	Transcriptional regulator
CIW82_09485	COG0446	pyridine nucleotide-disulphide oxidoreductase
CIW82_09525	COG4771	TonB-dependent receptor
CIW82_09545	COG0439	Biotin carboxylase
CIW82_09555	COG2205	protein histidine kinase activity
CIW82_09555	COG2202	Pas domain
CIW82_09565	COG2198	Histidine kinase
CIW82_09565	COG0784	Response regulator, receiver
CIW82_09565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CIW82_09565	COG2205	protein histidine kinase activity
CIW82_09570	COG0745	RESPONSE REGULATOR receiver
CIW82_09570	COG3706	GGDEF domain
CIW82_09575	COG0457	Tetratricopeptide repeat
CIW82_09610	COG3540	Alkaline phosphatase
CIW82_09615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIW82_09615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIW82_09635	COG4774	siderophore transport
CIW82_09655	COG0848	biopolymer transport protein
CIW82_09680	COG2837	iron assimilation
CIW82_09685	COG1271	oxidase subunit
CIW82_09690	COG1294	oxidase, subunit
CIW82_09705	COG0243	molybdopterin cofactor binding
CIW82_09715	COG0583	DNA-binding transcription factor activity
CIW82_09760	COG0723	plastoquinol--plastocyanin reductase activity
CIW82_09765	COG2857	Cytochrome c1
CIW82_09765	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CIW82_09770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CIW82_09780	COG0307	riboflavin synthase, alpha
CIW82_09785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIW82_09785	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIW82_09790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CIW82_09825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIW82_09835	COG1566	PFAM secretion protein HlyD family protein
CIW82_09865	COG0521	Mo-molybdopterin cofactor biosynthetic process
CIW82_09880	COG0302	gtp cyclohydrolase
CIW82_09900	COG0494	nUDIX hydrolase
CIW82_09930	COG2755	lipolytic protein G-D-S-L family
CIW82_09930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CIW82_09940	COG4974	Belongs to the 'phage' integrase family
CIW82_09960	COG0004	ammonium transporteR
CIW82_09975	COG0347	Belongs to the P(II) protein family
CIW82_09980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CIW82_09990	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CIW82_09995	COG0459	protein refolding
CIW82_10000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CIW82_10005	COG0412	Dienelactone hydrolase
CIW82_10010	COG1278	Cold shock
CIW82_10015	COG1199	ATP-dependent helicase activity
CIW82_10020	COG1064	alcohol dehydrogenase
CIW82_10025	COG0483	inositol monophosphate 1-phosphatase activity
CIW82_10030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CIW82_10095	COG0071	Belongs to the small heat shock protein (HSP20) family
CIW82_10100	COG3335	DDE superfamily endonuclease
CIW82_10125	COG2207	Transcriptional regulator
CIW82_10140	COG0583	DNA-binding transcription factor activity
CIW82_10150	COG0583	DNA-binding transcription factor activity
CIW82_10160	COG1733	regulation of RNA biosynthetic process
CIW82_10200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIW82_10205	COG0587	DNA-directed DNA polymerase activity
CIW82_10210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CIW82_10260	COG1204	response to ionizing radiation
CIW82_10285	COG1999	signal sequence binding
CIW82_10290	COG0582	viral genome integration into host DNA
CIW82_10310	COG0778	Nitroreductase
CIW82_10335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CIW82_10350	COG2070	2-Nitropropane dioxygenase
CIW82_10360	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CIW82_10400	COG0656	L-ascorbic acid biosynthetic process
CIW82_10415	COG1643	Atp-dependent helicase
CIW82_10430	COG2824	Alkylphosphonate utilization operon protein PhnA
CIW82_10440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CIW82_10450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CIW82_10455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CIW82_10470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIW82_10475	COG0235	Class ii aldolase
CIW82_10480	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CIW82_10485	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CIW82_10490	COG0196	riboflavin kinase activity
CIW82_10495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CIW82_10500	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CIW82_10510	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CIW82_10525	COG0187	DNA topoisomerase II activity
CIW82_10545	COG1959	2 iron, 2 sulfur cluster binding
CIW82_10550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CIW82_10565	COG2885	chlorophyll binding
CIW82_10565	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CIW82_10575	COG0793	Belongs to the peptidase S41A family
CIW82_10580	COG0557	exoribonuclease II activity
CIW82_10585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIW82_10590	COG0758	DNA mediated transformation
CIW82_10595	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CIW82_10600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CIW82_10605	COG0540	Belongs to the ATCase OTCase family
CIW82_10610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CIW82_10620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CIW82_10625	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CIW82_10635	COG0508	dehydrogenase complex catalyzes the overall conversion of
CIW82_10640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CIW82_10650	COG0277	FAD linked oxidase domain protein
CIW82_10660	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CIW82_10665	COG0204	Acyl-transferase
CIW82_10665	COG0318	PFAM AMP-dependent synthetase and ligase
CIW82_10680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIW82_10710	COG0649	NAD binding
CIW82_10715	COG3260	NADH ubiquinone oxidoreductase 20
CIW82_10725	COG0688	phosphatidylethanolamine metabolic process
CIW82_10730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CIW82_10740	COG2885	chlorophyll binding
CIW82_10740	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CIW82_10745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CIW82_10755	COG4974	Belongs to the 'phage' integrase family
CIW82_10760	COG0825	malonyl-CoA metabolic process
CIW82_10765	COG1058	Belongs to the CinA family
CIW82_10765	COG1546	Belongs to the CinA family
CIW82_10770	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CIW82_10785	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CIW82_10790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CIW82_10795	COG0181	hydroxymethylbilane synthase activity
CIW82_10810	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CIW82_10830	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CIW82_10835	COG1858	cytochrome C peroxidase
CIW82_10850	COG0408	coproporphyrinogen oxidase activity
CIW82_10855	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CIW82_10860	COG2857	Cytochrome c1
CIW82_10860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CIW82_10865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CIW82_10920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CIW82_10925	COG1902	pentaerythritol trinitrate reductase activity
CIW82_10945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CIW82_10955	COG0019	diaminopimelate decarboxylase activity
CIW82_10960	COG0165	Argininosuccinate lyase
CIW82_10980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CIW82_10985	COG0237	dephospho-CoA kinase activity
CIW82_10990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CIW82_11015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CIW82_11025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CIW82_11030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CIW82_11045	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CIW82_11050	COG0248	Ppx GppA phosphatase
CIW82_11080	COG0402	S-adenosylhomocysteine deaminase activity
CIW82_11095	COG1289	transmembrane transporter activity
CIW82_11100	COG1289	transmembrane transporter activity
CIW82_11115	COG4235	cytochrome complex assembly
CIW82_11120	COG3088	subunit of a heme lyase
CIW82_11125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIW82_11130	COG1138	Cytochrome C-type biogenesis protein
CIW82_11135	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CIW82_11145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CIW82_11185	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CIW82_11220	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CIW82_11225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CIW82_11235	COG0477	Major facilitator Superfamily
CIW82_11240	COG1301	dicarboxylic acid transport
CIW82_11245	COG1322	Protein conserved in bacteria
CIW82_11250	COG0745	RESPONSE REGULATOR receiver
CIW82_11255	COG0642	Histidine kinase
CIW82_11275	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CIW82_11280	COG0081	regulation of translation
CIW82_11290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CIW82_11295	COG0222	ribosome binding
CIW82_11300	COG0085	RNA polymerase activity
CIW82_11305	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CIW82_11310	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CIW82_11315	COG0049	tRNA binding
CIW82_11320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CIW82_11325	COG0051	transcription antitermination factor activity, RNA binding
CIW82_11330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CIW82_11335	COG0088	Forms part of the polypeptide exit tunnel
CIW82_11340	COG0089	rRNA binding
CIW82_11345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CIW82_11350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CIW82_11355	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CIW82_11360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CIW82_11365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CIW82_11370	COG0255	Belongs to the universal ribosomal protein uL29 family
CIW82_11375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CIW82_11380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CIW82_11385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CIW82_11390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CIW82_11395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CIW82_11400	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CIW82_11405	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CIW82_11410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CIW82_11415	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CIW82_11420	COG1841	ribosomal large subunit assembly
CIW82_11425	COG0200	Binds to the 23S rRNA
CIW82_11430	COG0201	protein transport
CIW82_11435	COG0563	adenylate kinase activity
CIW82_11440	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CIW82_11445	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CIW82_11450	COG0202	RNA polymerase activity
CIW82_11455	COG0203	ribosomal protein L17
CIW82_11460	COG2814	Major facilitator Superfamily
CIW82_11475	COG1116	anion transmembrane transporter activity
CIW82_11485	COG5487	UPF0391 membrane protein
CIW82_11505	COG1538	Outer membrane efflux protein
CIW82_11515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIW82_11520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW82_11535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CIW82_11565	COG0714	Associated with various cellular activities
CIW82_11575	COG0617	tRNA 3'-terminal CCA addition
CIW82_11580	COG1132	(ABC) transporter
CIW82_11585	COG1566	PFAM secretion protein HlyD family protein
CIW82_11590	COG2814	Major facilitator Superfamily
CIW82_11595	COG1051	belongs to the nudix hydrolase family
CIW82_11605	COG0793	Belongs to the peptidase S41A family
CIW82_11615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CIW82_11625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CIW82_11630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CIW82_11635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CIW82_11640	COG0505	Belongs to the CarA family
CIW82_11650	COG0358	DNA primase activity
CIW82_11655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CIW82_11665	COG0360	Binds together with S18 to 16S ribosomal RNA
CIW82_11670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CIW82_11675	COG0359	binds to the 23S rRNA
CIW82_11680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CIW82_11685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CIW82_11695	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CIW82_11710	COG0656	L-ascorbic acid biosynthetic process
CIW82_11720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CIW82_11720	COG1648	precorrin-2 dehydrogenase activity
CIW82_11725	COG1132	(ABC) transporter
CIW82_11730	COG1802	Transcriptional regulator
CIW82_11735	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CIW82_11745	COG0850	regulation of cytokinetic process
CIW82_11755	COG2081	HI0933 family
CIW82_11760	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CIW82_11770	COG0859	PFAM glycosyl transferase family 9
CIW82_11770	COG0457	Tetratricopeptide repeat
CIW82_11780	COG3781	membrane
CIW82_11785	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CIW82_11800	COG2884	Cell division ATP-binding protein ftsE
CIW82_11825	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CIW82_11830	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CIW82_11855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CIW82_11855	COG2010	Cytochrome c
CIW82_11860	COG0246	Mannitol dehydrogenase
CIW82_11865	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CIW82_11870	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CIW82_11875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CIW82_11880	COG0072	phenylalanine-tRNA ligase activity
CIW82_11880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIW82_11890	COG0596	Alpha beta hydrolase
CIW82_11910	COG0747	negative chemotaxis
CIW82_11920	COG0114	fumarate hydratase activity
CIW82_11935	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CIW82_11950	COG2814	Major facilitator Superfamily
CIW82_11960	COG0473	3-isopropylmalate dehydrogenase activity
CIW82_11965	COG0006	proline dipeptidase activity
CIW82_11970	COG2264	protein methyltransferase activity
CIW82_11975	COG0210	DNA helicase
CIW82_11980	COG2003	Belongs to the UPF0758 family
CIW82_11985	COG2003	Belongs to the UPF0758 family
CIW82_11990	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CIW82_12015	COG0071	Belongs to the small heat shock protein (HSP20) family
CIW82_12020	COG0254	rRNA binding
CIW82_12025	COG1970	mechanosensitive ion channel activity
CIW82_12110	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CIW82_12115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CIW82_12125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CIW82_12125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CIW82_12140	COG0142	geranyltranstransferase activity
CIW82_12145	COG2223	nitrite transmembrane transporter activity
CIW82_12155	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CIW82_12160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CIW82_12190	COG1605	Chorismate mutase
CIW82_12190	COG0287	Prephenate dehydrogenase
CIW82_12210	COG1196	nuclear chromosome segregation
CIW82_12215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CIW82_12225	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CIW82_12235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIW82_12245	COG0729	surface antigen
CIW82_12265	COG0322	excinuclease ABC activity
CIW82_12280	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CIW82_12285	COG0314	molybdopterin synthase activity
CIW82_12290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CIW82_12295	COG0156	8-amino-7-oxononanoate synthase activity
CIW82_12305	COG4106	trans-aconitate 2-methyltransferase activity
CIW82_12305	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CIW82_12310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CIW82_12320	COG0303	'Molybdopterin
CIW82_12325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CIW82_12345	COG0148	phosphopyruvate hydratase activity
CIW82_12365	COG2022	thiamine diphosphate biosynthetic process
CIW82_12380	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CIW82_12385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CIW82_12415	COG0076	glutamate decarboxylase activity
CIW82_12430	COG0484	heat shock protein binding
CIW82_12435	COG5007	Belongs to the BolA IbaG family
CIW82_12445	COG0321	lipoyl(octanoyl) transferase activity
CIW82_12465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CIW82_12495	COG2706	6-phosphogluconolactonase activity
CIW82_12500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CIW82_12510	COG0527	aspartate kinase activity
CIW82_12515	COG2070	2-Nitropropane dioxygenase
CIW82_12525	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CIW82_12530	COG0124	histidyl-tRNA synthetase
CIW82_12535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CIW82_12545	COG2890	protein-(glutamine-N5) methyltransferase activity
CIW82_12565	COG1968	undecaprenyl-diphosphatase activity
CIW82_12570	COG0531	amino acid
CIW82_12580	COG0586	Pfam SNARE associated Golgi protein
CIW82_12585	COG2951	lytic endotransglycosylase activity
CIW82_12590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CIW82_12595	COG1686	Belongs to the peptidase S11 family
CIW82_12600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CIW82_12610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIW82_12615	COG0084	hydrolase, TatD family'
CIW82_12630	COG0259	pyridoxamine-phosphate oxidase activity
CIW82_12635	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CIW82_12640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CIW82_12645	COG1764	response to oxidative stress
CIW82_12650	COG0579	oxidoreductase
CIW82_12660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CIW82_12665	COG0602	queuosine metabolic process
CIW82_12670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CIW82_12675	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_12680	COG0583	DNA-binding transcription factor activity
CIW82_12690	COG0175	sulfate reduction
CIW82_12695	COG0175	sulfate reduction
CIW82_12705	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CIW82_12710	COG4208	sulfate ABC transporter
CIW82_12715	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CIW82_12725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CIW82_12735	COG1519	Transferase
CIW82_12740	COG1663	tetraacyldisaccharide 4'-kinase activity
CIW82_12765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CIW82_12770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CIW82_12775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CIW82_12785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CIW82_12815	COG1278	Cold shock
CIW82_12820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CIW82_12825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CIW82_12830	COG1605	Chorismate mutase
CIW82_12830	COG0077	Prephenate dehydratase
CIW82_12835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CIW82_12850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CIW82_12860	COG0626	cystathionine gamma-synthase activity
CIW82_12865	COG2897	thiosulfate sulfurtransferase activity
CIW82_12870	COG0628	permease
CIW82_12880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIW82_12885	COG0792	nuclease activity
CIW82_12895	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CIW82_12900	COG0271	Belongs to the BolA IbaG family
CIW82_12905	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CIW82_12910	COG0047	phosphoribosylformylglycinamidine synthase activity
CIW82_12920	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CIW82_12925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CIW82_12930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CIW82_12935	COG0861	Integral membrane protein TerC family
CIW82_12945	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CIW82_12960	COG2867	negative regulation of translational initiation
CIW82_12965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CIW82_12970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CIW82_12975	COG0508	dehydrogenase complex catalyzes the overall conversion of
CIW82_12980	COG0508	dehydrogenase complex catalyzes the overall conversion of
CIW82_12980	COG0022	dehydrogenase e1 component
CIW82_12985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CIW82_12995	COG0134	indole-3-glycerol-phosphate synthase activity
CIW82_13000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CIW82_13010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CIW82_13020	COG0149	triose-phosphate isomerase activity
CIW82_13025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CIW82_13030	COG0504	CTP synthase activity
CIW82_13035	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CIW82_13040	COG0187	DNA topoisomerase II activity
CIW82_13045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CIW82_13050	COG0592	DNA-directed DNA polymerase activity
CIW82_13055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CIW82_13060	COG0268	Binds directly to 16S ribosomal RNA
CIW82_13065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CIW82_13070	COG2226	methyltransferase
CIW82_13075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CIW82_13080	COG0756	dUTP diphosphatase activity
CIW82_13090	COG1116	anion transmembrane transporter activity
CIW82_13095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CIW82_13100	COG0525	valine-tRNA ligase activity
CIW82_13125	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_13130	COG0456	acetyltransferase
CIW82_13135	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CIW82_13140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CIW82_13145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CIW82_13155	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CIW82_13175	COG0514	ATP-dependent DNA helicase (RecQ)
CIW82_13185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CIW82_13190	COG4988	ABC transporter
CIW82_13210	COG0784	Response regulator, receiver
CIW82_13470	COG5484	DNA packaging
CIW82_13470	COG3728	DNA packaging
CIW82_13515	COG3750	Belongs to the UPF0335 family
CIW82_13620	COG4974	Belongs to the 'phage' integrase family
CIW82_13640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CIW82_13640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CIW82_13660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CIW82_13675	COG0297	glycogen (starch) synthase activity
CIW82_13680	COG3387	PFAM Glycoside hydrolase 15-related
CIW82_13715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CIW82_13730	COG2233	PERMEase
CIW82_13735	COG2351	hydroxyisourate hydrolase activity
CIW82_13750	COG2072	flavoprotein involved in K transport
CIW82_13775	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CIW82_13785	COG2252	PERMEase
CIW82_13825	COG0583	DNA-binding transcription factor activity
CIW82_13875	COG2099	Precorrin-6x reductase
CIW82_13890	COG2875	Belongs to the precorrin methyltransferase family
CIW82_13895	COG1797	cobyrinic acid a,c-diamide synthase activity
CIW82_13950	COG1953	Uracil, thiamine, allantoin
CIW82_13960	COG3459	Glycosyltransferase 36 associated
CIW82_14010	COG0583	DNA-binding transcription factor activity
CIW82_14025	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_14045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIW82_14050	COG2814	Major facilitator Superfamily
CIW82_14055	COG0583	DNA-binding transcription factor activity
CIW82_14060	COG3328	transposase activity
CIW82_14075	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CIW82_14085	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CIW82_14090	COG1414	Transcriptional regulator
CIW82_14105	COG0741	lytic transglycosylase activity
CIW82_14160	COG5489	Protein of unknown function (DUF736)
CIW82_14245	COG0625	glutathione transferase activity
CIW82_14250	COG0587	DNA-directed DNA polymerase activity
CIW82_14255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CIW82_14265	COG0210	DNA helicase
CIW82_14275	COG0697	spore germination
CIW82_14300	COG3701	Conjugal transfer protein
CIW82_14305	COG3846	protein secretion by the type IV secretion system
CIW82_14315	COG3451	type IV secretory pathway VirB4
CIW82_14325	COG3838	Conjugal transfer protein Trbc
CIW82_14330	COG4962	Type ii secretion system protein e
CIW82_14415	COG0435	Glutathione S-transferase
CIW82_14420	COG1763	Mo-molybdopterin cofactor biosynthetic process
CIW82_14435	COG2864	formate dehydrogenase
CIW82_14440	COG0437	4 iron, 4 sulfur cluster binding
CIW82_14445	COG3383	formate dehydrogenase (NAD+) activity
CIW82_14445	COG0243	molybdopterin cofactor binding
CIW82_14460	COG0277	FAD linked oxidase domain protein
CIW82_14485	COG2999	glutathione oxidoreductase activity
CIW82_14495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIW82_14500	COG3511	phospholipase C
CIW82_14505	COG1858	cytochrome C peroxidase
CIW82_14515	COG0295	cytidine deaminase activity
CIW82_14530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CIW82_14535	COG1957	nucleoside hydrolase
CIW82_14540	COG0500	methyltransferase
CIW82_14550	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CIW82_14555	COG0248	Ppx GppA phosphatase
CIW82_14565	COG0745	RESPONSE REGULATOR receiver
CIW82_14570	COG5002	protein histidine kinase activity
CIW82_14590	COG1012	belongs to the aldehyde dehydrogenase family
CIW82_14595	COG1940	carbohydrate kinase activity
CIW82_14600	COG0425	Belongs to the sulfur carrier protein TusA family
CIW82_14605	COG1722	exodeoxyribonuclease VII activity
CIW82_14610	COG0142	geranyltranstransferase activity
CIW82_14615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CIW82_14620	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CIW82_14630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CIW82_14635	COG0137	argininosuccinate synthase activity
CIW82_14640	COG0545	Peptidyl-prolyl cis-trans isomerase
CIW82_14650	COG0180	Tryptophanyl-tRNA synthetase
CIW82_14670	COG1289	transmembrane transporter activity
CIW82_14675	COG0583	DNA-binding transcription factor activity
CIW82_14680	COG3328	transposase activity
CIW82_14690	COG1607	acyl-coa hydrolase
CIW82_14700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIW82_14705	COG1129	ABC transporter
CIW82_14705	COG0842	Transport permease protein
CIW82_14710	COG0842	Transport permease protein
CIW82_14725	COG2010	Cytochrome c
CIW82_14740	COG1309	transcriptional regulator
CIW82_14770	COG1028	Short-chain dehydrogenase reductase Sdr
CIW82_14775	COG1960	acyl-CoA dehydrogenase activity
CIW82_14805	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW82_14810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW82_14815	COG0649	NAD binding
CIW82_14815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW82_14830	COG1034	ATP synthesis coupled electron transport
CIW82_14835	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CIW82_14840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW82_14845	COG0839	Belongs to the complex I subunit 6 family
CIW82_14850	COG0713	ATP synthesis coupled electron transport
CIW82_14880	COG0848	biopolymer transport protein
CIW82_14895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIW82_14905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CIW82_14930	COG0747	negative chemotaxis
CIW82_14935	COG0601	transmembrane transport
CIW82_14945	COG4172	Belongs to the ABC transporter superfamily
CIW82_14955	COG2826	transposase and inactivated derivatives, IS30 family
CIW82_14960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CIW82_14970	COG1116	anion transmembrane transporter activity
CIW82_14975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CIW82_14990	COG1695	Transcriptional regulator
CIW82_15025	COG0697	spore germination
CIW82_15030	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CIW82_15035	COG1984	allophanate hydrolase subunit 2
CIW82_15045	COG4221	oxidoreductase activity
CIW82_15090	COG2271	Major facilitator Superfamily
CIW82_15095	COG1024	Enoyl-CoA hydratase
CIW82_15100	COG4774	siderophore transport
CIW82_15140	COG2814	Major facilitator Superfamily
CIW82_15170	COG3119	arylsulfatase activity
CIW82_15195	COG0446	pyridine nucleotide-disulphide oxidoreductase
CIW82_15200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CIW82_15200	COG1116	anion transmembrane transporter activity
CIW82_15205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CIW82_15210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CIW82_15210	COG1116	anion transmembrane transporter activity
CIW82_15225	COG4774	siderophore transport
CIW82_15230	COG1120	ATPase activity
CIW82_15275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CIW82_15285	COG1309	transcriptional regulator
CIW82_15290	COG2211	Major facilitator Superfamily
CIW82_15295	COG4977	sequence-specific DNA binding
CIW82_15295	COG1917	Cupin 2, conserved barrel domain protein
CIW82_15310	COG1566	PFAM secretion protein HlyD family protein
CIW82_15395	COG1902	pentaerythritol trinitrate reductase activity
CIW82_15400	COG0583	DNA-binding transcription factor activity
CIW82_15410	COG1538	Outer membrane efflux protein
CIW82_15430	COG0655	NAD(P)H dehydrogenase (quinone) activity
CIW82_15440	COG1741	Belongs to the pirin family
CIW82_15470	COG2807	transmembrane transport
CIW82_15475	COG0640	Transcriptional regulator
CIW82_15505	COG0741	lytic transglycosylase activity
CIW82_15560	COG5489	Protein of unknown function (DUF736)
CIW82_15620	COG4372	Transposase
CIW82_15675	COG0625	glutathione transferase activity
CIW82_15680	COG0587	DNA-directed DNA polymerase activity
CIW82_15685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CIW82_15705	COG0697	spore germination
CIW82_15730	COG3701	Conjugal transfer protein
CIW82_15745	COG3451	type IV secretory pathway VirB4
CIW82_15755	COG3838	Conjugal transfer protein Trbc
CIW82_15760	COG4962	Type ii secretion system protein e
CIW82_15830	COG0318	PFAM AMP-dependent synthetase and ligase
CIW82_15840	COG0156	8-amino-7-oxononanoate synthase activity
CIW82_15855	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CIW82_15885	COG0546	phosphoglycolate phosphatase activity
CIW82_15890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CIW82_15895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CIW82_15910	COG0386	Belongs to the glutathione peroxidase family
CIW82_15915	COG1136	(ABC) transporter
CIW82_15925	COG0442	prolyl-tRNA aminoacylation
CIW82_15935	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CIW82_15945	COG1007	ATP synthesis coupled electron transport
CIW82_15955	COG0713	ATP synthesis coupled electron transport
CIW82_15965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW82_15970	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CIW82_15975	COG1034	ATP synthesis coupled electron transport
CIW82_15985	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CIW82_15990	COG0649	NAD binding
CIW82_15995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW82_16000	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW82_16005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIW82_16015	COG0776	regulation of translation
CIW82_16025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CIW82_16030	COG0740	serine-type endopeptidase activity
CIW82_16035	COG0544	peptidyl-prolyl cis-trans isomerase activity
CIW82_16045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CIW82_16045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CIW82_16065	COG0513	Belongs to the DEAD box helicase family
CIW82_16075	COG0316	Belongs to the HesB IscA family
CIW82_16080	COG2151	metal-sulfur cluster biosynthetic enzyme
CIW82_16090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CIW82_16095	COG0719	Fe-S assembly protein
CIW82_16100	COG0396	ATPase activity
CIW82_16105	COG0719	Fe-S assembly protein
CIW82_16115	COG2733	membrane
CIW82_16140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CIW82_16145	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CIW82_16155	COG5265	(ABC) transporter
CIW82_16165	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CIW82_16170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CIW82_16195	COG0612	Peptidase, M16
CIW82_16200	COG0312	modulator of DNA gyrase
CIW82_16215	COG0109	protoheme IX farnesyltransferase activity
CIW82_16220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CIW82_16225	COG2226	methyltransferase
CIW82_16245	COG1215	transferase activity, transferring glycosyl groups
CIW82_16250	COG1522	sequence-specific DNA binding
CIW82_16255	COG0492	ferredoxin-NADP+ reductase activity
CIW82_16260	COG0583	DNA-binding transcription factor activity
CIW82_16270	COG4957	zinc ion binding
CIW82_16275	COG0776	regulation of translation
CIW82_16280	COG1573	uracil-dna glycosylase
CIW82_16305	COG0776	regulation of translation
CIW82_16310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIW82_16315	COG0416	fatty acid biosynthetic process
CIW82_16320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CIW82_16335	COG2205	protein histidine kinase activity
CIW82_16340	COG0745	RESPONSE REGULATOR receiver
CIW82_16345	COG1846	Transcriptional regulator
CIW82_16355	COG0242	peptide deformylase activity
CIW82_16360	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CIW82_16365	COG1505	serine-type exopeptidase activity
CIW82_16370	COG0473	3-isopropylmalate dehydrogenase activity
CIW82_16375	COG0066	3-isopropylmalate dehydratase activity
CIW82_16380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CIW82_16385	COG0335	large ribosomal subunit rRNA binding
CIW82_16390	COG0336	Belongs to the RNA methyltransferase TrmD family
CIW82_16395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CIW82_16400	COG0228	four-way junction DNA binding
CIW82_16425	COG2982	Protein involved in outer membrane biogenesis
CIW82_16430	COG0564	pseudouridine synthase activity
CIW82_16435	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CIW82_16445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CIW82_16460	COG2814	Major facilitator Superfamily
CIW82_16470	COG1160	GTP binding
CIW82_16510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CIW82_16520	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIW82_16525	COG0659	secondary active sulfate transmembrane transporter activity
CIW82_16545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CIW82_16560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CIW82_16585	COG0542	response to heat
CIW82_16595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CIW82_16605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CIW82_16610	COG1923	regulation of RNA biosynthetic process
CIW82_16615	COG2204	response regulator
CIW82_16640	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CIW82_16640	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CIW82_16645	COG0463	Glycosyl transferase, family 2
CIW82_16650	COG0463	Glycosyl transferase, family 2
CIW82_16670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CIW82_16680	COG0009	L-threonylcarbamoyladenylate synthase
CIW82_16720	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CIW82_16725	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CIW82_16750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CIW82_16770	COG0506	proline dehydrogenase activity
CIW82_16770	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CIW82_16770	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CIW82_16815	COG0028	Belongs to the TPP enzyme family
CIW82_16830	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CIW82_16835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CIW82_16840	COG1127	ABC transporter
CIW82_16845	COG1196	nuclear chromosome segregation
CIW82_16845	COG3264	Mechanosensitive ion channel
CIW82_16850	COG0305	Participates in initiation and elongation during chromosome replication
CIW82_16855	COG2942	2-epimerase
CIW82_16860	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CIW82_16860	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CIW82_16865	COG0194	GDP metabolic process
CIW82_16870	COG0300	oxidoreductase activity
CIW82_16880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CIW82_16890	COG0477	Major facilitator Superfamily
CIW82_16900	COG0517	IMP dehydrogenase activity
CIW82_16900	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CIW82_16915	COG1137	ATPase activity
CIW82_16925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CIW82_16935	COG1216	Glycosyl transferase, family 2
CIW82_16940	COG1216	Glycosyl transferase, family 2
CIW82_16975	COG3328	transposase activity
CIW82_16990	COG3328	transposase activity
CIW82_17015	COG0242	peptide deformylase activity
CIW82_17020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CIW82_17025	COG0101	tRNA pseudouridine synthase activity
CIW82_17030	COG1671	Belongs to the UPF0178 family
CIW82_17040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CIW82_17045	COG2171	N-acyltransferase activity
CIW82_17050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CIW82_17055	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CIW82_17060	COG0706	membrane insertase activity
CIW82_17065	COG0594	ribonuclease P activity
CIW82_17070	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CIW82_17080	COG0346	lactoylglutathione lyase activity
CIW82_17085	COG3494	Protein of unknown function (DUF1009)
CIW82_17090	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIW82_17095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CIW82_17100	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CIW82_17110	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CIW82_17115	COG0750	zinc metalloprotease
CIW82_17120	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CIW82_17125	COG0575	Belongs to the CDS family
CIW82_17130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CIW82_17135	COG0233	cytoplasmic translational termination
CIW82_17140	COG0528	UMP kinase activity
CIW82_17145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CIW82_17150	COG0571	ribonuclease III activity
CIW82_17155	COG0681	Belongs to the peptidase S26 family
CIW82_17160	COG0736	holo-[acyl-carrier-protein] synthase activity
CIW82_17165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CIW82_17170	COG1758	RNA polymerase activity
CIW82_17175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CIW82_17195	COG0513	Belongs to the DEAD box helicase family
CIW82_17200	COG2813	Specifically methylates the guanine in position
CIW82_17200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CIW82_17205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CIW82_17210	COG0481	GTPase activity
CIW82_17225	COG0488	(ABC) transporter
CIW82_17235	COG4993	Dehydrogenase
CIW82_17290	COG3104	oligopeptide transport
CIW82_17295	COG0538	isocitrate dehydrogenase activity
CIW82_17300	COG0492	ferredoxin-NADP+ reductase activity
CIW82_17305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CIW82_17310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIW82_17365	COG0469	pyruvate kinase activity
CIW82_17380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CIW82_17405	COG1297	OPT oligopeptide transporter protein
CIW82_17410	COG4774	siderophore transport
CIW82_17415	COG0596	Alpha beta hydrolase
CIW82_17420	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CIW82_17430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CIW82_17445	COG0523	cobalamin synthesis protein
CIW82_17455	COG1252	NADH dehydrogenase
CIW82_17460	COG0071	Belongs to the small heat shock protein (HSP20) family
CIW82_17470	COG0022	dehydrogenase e1 component
CIW82_17475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CIW82_17480	COG2346	COG2346, Truncated hemoglobins
CIW82_17485	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CIW82_17485	COG2755	lipolytic protein G-D-S-L family
CIW82_17495	COG1131	(ABC) transporter
CIW82_17500	COG2814	Major facilitator Superfamily
CIW82_17510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CIW82_17515	COG3590	peptidase
CIW82_17550	COG2186	Transcriptional regulator
CIW82_17555	COG1301	dicarboxylic acid transport
CIW82_17575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CIW82_17580	COG1607	acyl-coa hydrolase
CIW82_17605	COG4771	TonB-dependent receptor
CIW82_17615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CIW82_17620	COG0697	spore germination
CIW82_17630	COG4221	oxidoreductase activity
CIW82_17640	COG1492	cobalamin metabolic process
CIW82_17670	COG1538	Outer membrane efflux protein
CIW82_17680	COG1289	transmembrane transporter activity
CIW82_17695	COG1024	Enoyl-CoA hydratase
CIW82_17695	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIW82_17705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CIW82_17710	COG1121	(ABC) transporter
CIW82_17720	COG0735	belongs to the Fur family
CIW82_17740	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CIW82_17770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CIW82_17770	COG0519	Catalyzes the synthesis of GMP from XMP
CIW82_17805	COG0741	lytic transglycosylase activity
CIW82_17810	COG1620	l-lactate permease
CIW82_17825	COG1704	LemA family
CIW82_17835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CIW82_17870	COG1742	UPF0060 membrane protein
CIW82_17875	COG0306	phosphate transporter
CIW82_17890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CIW82_17910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CIW82_17915	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CIW82_17920	COG0561	phosphatase activity
CIW82_17930	COG0363	glucosamine-6-phosphate deaminase activity
CIW82_17975	COG3158	transport of potassium into the cell
CIW82_17980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIW82_18000	COG0339	signal peptide processing
CIW82_18005	COG1914	H( )-stimulated, divalent metal cation uptake system
CIW82_18010	COG1321	iron dependent repressor
CIW82_18110	COG0038	chloride channel
CIW82_18115	COG2217	Heavy metal translocating P-type atpase
CIW82_18125	COG0243	molybdopterin cofactor binding
CIW82_18175	COG3038	cytochrome b561
CIW82_18185	COG3328	transposase activity
CIW82_18195	COG1902	pentaerythritol trinitrate reductase activity
CIW82_18220	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
CIW82_18235	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CIW82_18250	COG0517	IMP dehydrogenase activity
CIW82_18255	COG4974	Belongs to the 'phage' integrase family
CIW82_18270	COG1475	DNA binding
CIW82_18275	COG1192	Involved in chromosome partitioning
CIW82_18290	COG1475	DNA binding
CIW82_18310	COG4227	nucleotidyltransferase activity
CIW82_18325	COG0629	single-stranded DNA binding
CIW82_18340	COG0210	DNA helicase
CIW82_18365	COG3328	transposase activity
CIW82_18380	COG3328	transposase activity
CIW82_18445	COG0675	Transposase, IS605 OrfB family
CIW82_18485	COG0629	single-stranded DNA binding
CIW82_18550	COG3328	transposase activity
CIW82_18605	COG1492	cobalamin metabolic process
CIW82_18635	COG4372	Transposase
CIW82_18800	COG3750	Belongs to the UPF0335 family
CIW82_18815	COG0640	Transcriptional regulator
CIW82_18845	COG3852	Histidine kinase
CIW82_18850	COG2204	response regulator
CIW82_18860	COG1136	(ABC) transporter
CIW82_18910	COG1959	2 iron, 2 sulfur cluster binding
CIW82_18925	COG2072	flavoprotein involved in K transport
CIW82_18930	COG0431	NADPH-dependent FMN reductase