locus-tag	class	description
DM15PD_00040	COG0626	cystathionine gamma-synthase activity
DM15PD_00070	COG0741	lytic transglycosylase activity
DM15PD_00080	COG0861	Integral membrane protein TerC family
DM15PD_00090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DM15PD_00100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DM15PD_00110	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DM15PD_00130	COG0047	phosphoribosylformylglycinamidine synthase activity
DM15PD_00140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DM15PD_00160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DM15PD_00180	COG0792	nuclease activity
DM15PD_00190	COG0113	porphobilinogen synthase activity
DM15PD_00200	COG0531	amino acid
DM15PD_00210	COG0531	amino acid
DM15PD_00220	COG0531	amino acid
DM15PD_00230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DM15PD_00240	COG0513	Belongs to the DEAD box helicase family
DM15PD_00670	COG3750	Belongs to the UPF0335 family
DM15PD_00900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DM15PD_00910	COG2814	Major facilitator Superfamily
DM15PD_00930	COG1271	oxidase subunit
DM15PD_00940	COG1294	oxidase, subunit
DM15PD_01240	COG1396	sequence-specific DNA binding
DM15PD_01270	COG0135	phosphoribosylanthranilate isomerase activity
DM15PD_01280	COG0284	orotidine-5'-phosphate decarboxylase activity
DM15PD_01310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DM15PD_01320	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DM15PD_01330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DM15PD_01360	COG0006	proline dipeptidase activity
DM15PD_01370	COG2264	protein methyltransferase activity
DM15PD_01390	COG2003	Belongs to the UPF0758 family
DM15PD_01400	COG2003	Belongs to the UPF0758 family
DM15PD_01410	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DM15PD_01450	COG0254	rRNA binding
DM15PD_01460	COG1970	mechanosensitive ion channel activity
DM15PD_01490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DM15PD_01500	COG0673	inositol 2-dehydrogenase activity
DM15PD_01510	COG0488	(ABC) transporter
DM15PD_01520	COG4988	ABC transporter
DM15PD_01530	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DM15PD_01570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DM15PD_01580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DM15PD_01590	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DM15PD_01620	COG0837	glucose binding
DM15PD_01640	COG1070	Carbohydrate kinase
DM15PD_01670	COG0673	inositol 2-dehydrogenase activity
DM15PD_01680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DM15PD_01690	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DM15PD_01700	COG0154	amidase activity
DM15PD_01710	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DM15PD_01780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DM15PD_01810	COG0525	valine-tRNA ligase activity
DM15PD_01820	COG0129	dihydroxy-acid dehydratase activity
DM15PD_01830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DM15PD_01860	COG0756	dUTP diphosphatase activity
DM15PD_01870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DM15PD_01880	COG2226	methyltransferase
DM15PD_01890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DM15PD_01900	COG0268	Binds directly to 16S ribosomal RNA
DM15PD_01910	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DM15PD_01930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DM15PD_01990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DM15PD_02000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DM15PD_02030	COG2223	nitrite transmembrane transporter activity
DM15PD_02100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DM15PD_02110	COG0318	PFAM AMP-dependent synthetase and ligase
DM15PD_02130	COG0156	8-amino-7-oxononanoate synthase activity
DM15PD_02240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DM15PD_02250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DM15PD_02260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DM15PD_02270	COG1028	Short-chain dehydrogenase reductase Sdr
DM15PD_02280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DM15PD_02300	COG3590	peptidase
DM15PD_02320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DM15PD_02380	COG0354	folic acid binding
DM15PD_02390	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DM15PD_02400	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DM15PD_02410	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DM15PD_02420	COG3781	membrane
DM15PD_02430	COG1329	Transcriptional regulator
DM15PD_02440	COG1028	Short-chain dehydrogenase reductase Sdr
DM15PD_02470	COG0729	surface antigen
DM15PD_02490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DM15PD_02500	COG1702	phosphate starvation-inducible protein PhoH
DM15PD_02510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DM15PD_02520	COG1253	flavin adenine dinucleotide binding
DM15PD_02540	COG1196	nuclear chromosome segregation
DM15PD_02620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DM15PD_02630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DM15PD_02640	COG0142	geranyltranstransferase activity
DM15PD_02670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DM15PD_02680	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DM15PD_02690	COG0259	pyridoxamine-phosphate oxidase activity
DM15PD_02710	COG1519	Transferase
DM15PD_02720	COG1663	tetraacyldisaccharide 4'-kinase activity
DM15PD_02760	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DM15PD_02780	COG3572	ergothioneine biosynthetic process
DM15PD_02810	COG2814	Major facilitator Superfamily
DM15PD_02820	COG2814	Major facilitator Superfamily
DM15PD_02830	COG1160	GTP binding
DM15PD_02890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DM15PD_02900	COG0237	dephospho-CoA kinase activity
DM15PD_02910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DM15PD_02930	COG0165	Argininosuccinate lyase
DM15PD_02960	COG1234	tRNA 3'-trailer cleavage
DM15PD_02970	COG0084	hydrolase, TatD family'
DM15PD_02980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DM15PD_03000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DM15PD_03010	COG1686	Belongs to the peptidase S11 family
DM15PD_03020	COG2951	lytic endotransglycosylase activity
DM15PD_03050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DM15PD_03060	COG1968	undecaprenyl-diphosphatase activity
DM15PD_03070	COG0531	amino acid
DM15PD_03100	COG2890	protein-(glutamine-N5) methyltransferase activity
DM15PD_03120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DM15PD_03130	COG0124	histidyl-tRNA synthetase
DM15PD_03140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DM15PD_03160	COG2070	2-Nitropropane dioxygenase
DM15PD_03170	COG0527	aspartate kinase activity
DM15PD_03180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DM15PD_03190	COG2706	6-phosphogluconolactonase activity
DM15PD_03210	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DM15PD_03220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DM15PD_03260	COG0321	lipoyl(octanoyl) transferase activity
DM15PD_03290	COG0484	heat shock protein binding
DM15PD_03350	COG1136	(ABC) transporter
DM15PD_03370	COG0442	prolyl-tRNA aminoacylation
DM15PD_03390	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DM15PD_03440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DM15PD_03450	COG0740	serine-type endopeptidase activity
DM15PD_03460	COG0544	peptidyl-prolyl cis-trans isomerase activity
DM15PD_03480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DM15PD_03480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DM15PD_03500	COG0513	Belongs to the DEAD box helicase family
DM15PD_03510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DM15PD_03530	COG2151	metal-sulfur cluster biosynthetic enzyme
DM15PD_03550	COG0719	Fe-S assembly protein
DM15PD_03560	COG0396	ATPase activity
DM15PD_03570	COG0719	Fe-S assembly protein
DM15PD_03590	COG2733	membrane
DM15PD_03630	COG0038	chloride channel
DM15PD_03640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DM15PD_03650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DM15PD_03660	COG5265	(ABC) transporter
DM15PD_03680	COG0628	permease
DM15PD_03710	COG0776	regulation of translation
DM15PD_03720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DM15PD_03730	COG0416	fatty acid biosynthetic process
DM15PD_03740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DM15PD_03770	COG1846	Transcriptional regulator
DM15PD_03780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DM15PD_03800	COG1522	sequence-specific DNA binding
DM15PD_03820	COG0583	DNA-binding transcription factor activity
DM15PD_03830	COG0776	regulation of translation
DM15PD_03840	COG4957	zinc ion binding
DM15PD_03850	COG1573	uracil-dna glycosylase
DM15PD_03860	COG1289	transmembrane transporter activity
DM15PD_03890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DM15PD_03900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DM15PD_03910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DM15PD_03930	COG1139	Iron-sulfur cluster binding protein
DM15PD_03990	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DM15PD_04010	COG2001	Belongs to the MraZ family
DM15PD_04020	COG0275	rRNA processing
DM15PD_04050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DM15PD_04070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DM15PD_04080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DM15PD_04100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DM15PD_04110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DM15PD_04120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DM15PD_04130	COG1181	Belongs to the D-alanine--D-alanine ligase family
DM15PD_04140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DM15PD_04180	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DM15PD_04190	COG0497	DNA recombination
DM15PD_04200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DM15PD_04210	COG1253	flavin adenine dinucleotide binding
DM15PD_04220	COG1335	isochorismatase
DM15PD_04280	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DM15PD_04300	COG0328	RNA-DNA hybrid ribonuclease activity
DM15PD_04310	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DM15PD_04320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DM15PD_04420	COG0436	Aminotransferase
DM15PD_04430	COG0436	Aminotransferase
DM15PD_04440	COG0473	3-isopropylmalate dehydrogenase activity
DM15PD_04450	COG0066	3-isopropylmalate dehydratase activity
DM15PD_04460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DM15PD_04470	COG0335	large ribosomal subunit rRNA binding
DM15PD_04480	COG0336	Belongs to the RNA methyltransferase TrmD family
DM15PD_04490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DM15PD_04500	COG0228	four-way junction DNA binding
DM15PD_04540	COG0513	Belongs to the DEAD box helicase family
DM15PD_04550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DM15PD_04550	COG2813	Specifically methylates the guanine in position
DM15PD_04560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DM15PD_04580	COG0778	Nitroreductase
DM15PD_04650	COG1692	metallophosphoesterase
DM15PD_04660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DM15PD_04730	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DM15PD_04740	COG1509	lysine 2,3-aminomutase activity
DM15PD_04750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DM15PD_04760	COG0483	inositol monophosphate 1-phosphatase activity
DM15PD_04800	COG0481	GTPase activity
DM15PD_04820	COG2252	PERMEase
DM15PD_04830	COG1722	exodeoxyribonuclease VII activity
DM15PD_04840	COG0142	geranyltranstransferase activity
DM15PD_04850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DM15PD_04860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DM15PD_04870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DM15PD_04880	COG0137	argininosuccinate synthase activity
DM15PD_04890	COG0545	Peptidyl-prolyl cis-trans isomerase
DM15PD_04900	COG0180	Tryptophanyl-tRNA synthetase
DM15PD_04920	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DM15PD_04930	COG0072	phenylalanine-tRNA ligase activity
DM15PD_04930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DM15PD_04940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DM15PD_04950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DM15PD_04960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DM15PD_04970	COG4993	Dehydrogenase
DM15PD_05000	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DM15PD_05010	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DM15PD_05050	COG1136	(ABC) transporter
DM15PD_05050	COG0577	efflux transmembrane transporter activity
DM15PD_05140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DM15PD_05160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DM15PD_05170	COG0688	phosphatidylethanolamine metabolic process
DM15PD_05180	COG1183	phosphatidylcholine synthase activity
DM15PD_05190	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DM15PD_05260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DM15PD_05270	COG1218	3'(2'),5'-bisphosphate nucleotidase
DM15PD_05280	COG0009	L-threonylcarbamoyladenylate synthase
DM15PD_05340	COG2942	2-epimerase
DM15PD_05350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DM15PD_05350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DM15PD_05380	COG0795	lipopolysaccharide-transporting ATPase activity
DM15PD_05410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DM15PD_05420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DM15PD_05450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DM15PD_05460	COG0359	binds to the 23S rRNA
DM15PD_05470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DM15PD_05480	COG0360	Binds together with S18 to 16S ribosomal RNA
DM15PD_05490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DM15PD_05510	COG0697	spore germination
DM15PD_05530	COG0505	Belongs to the CarA family
DM15PD_05540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DM15PD_05550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DM15PD_05560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DM15PD_05570	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DM15PD_05590	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DM15PD_05600	COG1012	belongs to the aldehyde dehydrogenase family
DM15PD_05610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DM15PD_05640	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DM15PD_05660	COG0793	Belongs to the peptidase S41A family
DM15PD_05670	COG0494	nUDIX hydrolase
DM15PD_05680	COG1132	(ABC) transporter
DM15PD_05710	COG0714	Associated with various cellular activities
DM15PD_05760	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DM15PD_05770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DM15PD_05810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM15PD_05820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM15PD_05850	COG0203	ribosomal protein L17
DM15PD_05860	COG0202	RNA polymerase activity
DM15PD_05870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DM15PD_05880	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DM15PD_05890	COG0563	adenylate kinase activity
DM15PD_05910	COG0200	Binds to the 23S rRNA
DM15PD_05920	COG1841	ribosomal large subunit assembly
DM15PD_05930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DM15PD_05940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DM15PD_05950	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DM15PD_05960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DM15PD_05970	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DM15PD_05980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DM15PD_05990	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DM15PD_06000	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DM15PD_06010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DM15PD_06020	COG0255	Belongs to the universal ribosomal protein uL29 family
DM15PD_06030	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DM15PD_06040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DM15PD_06050	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DM15PD_06060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DM15PD_06070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DM15PD_06080	COG0089	rRNA binding
DM15PD_06090	COG0088	Forms part of the polypeptide exit tunnel
DM15PD_06100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DM15PD_06110	COG0051	transcription antitermination factor activity, RNA binding
DM15PD_06120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DM15PD_06130	COG0049	tRNA binding
DM15PD_06140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DM15PD_06150	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DM15PD_06160	COG0085	RNA polymerase activity
DM15PD_06170	COG0222	ribosome binding
DM15PD_06180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DM15PD_06190	COG0081	regulation of translation
DM15PD_06200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DM15PD_06270	COG2081	HI0933 family
DM15PD_06290	COG0850	regulation of cytokinetic process
DM15PD_06310	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DM15PD_06320	COG3128	pkhd-type hydroxylase
DM15PD_06350	COG0495	leucyl-tRNA aminoacylation
DM15PD_06370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DM15PD_06380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DM15PD_06410	COG0138	bifunctional purine biosynthesis protein purh
DM15PD_06450	COG0800	Aldolase
DM15PD_06460	COG0129	dihydroxy-acid dehydratase activity
DM15PD_06470	COG0741	lytic transglycosylase activity
DM15PD_06490	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DM15PD_06510	COG1742	UPF0060 membrane protein
DM15PD_06520	COG0004	ammonium transporteR
DM15PD_06540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DM15PD_06550	COG1045	serine acetyltransferase
DM15PD_06560	COG2017	converts alpha-aldose to the beta-anomer
DM15PD_06590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DM15PD_06600	COG0343	queuine tRNA-ribosyltransferase activity
DM15PD_06620	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DM15PD_06640	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DM15PD_06650	COG0246	Mannitol dehydrogenase
DM15PD_06670	COG0489	protein tyrosine kinase activity
DM15PD_06700	COG0693	protein deglycase activity
DM15PD_06710	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DM15PD_06730	COG1538	Outer membrane efflux protein
DM15PD_06760	COG2814	Major facilitator Superfamily
DM15PD_06780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DM15PD_06810	COG4993	Dehydrogenase
DM15PD_06820	COG1309	transcriptional regulator
DM15PD_06850	COG4774	siderophore transport
DM15PD_06860	COG3128	pkhd-type hydroxylase
DM15PD_06880	COG0848	biopolymer transport protein
DM15PD_06900	COG0037	tRNA processing
DM15PD_06900	COG0590	tRNA wobble adenosine to inosine editing
DM15PD_06910	COG1187	pseudouridine synthase activity
DM15PD_06920	COG0742	ribosomal rna small subunit methyltransferase
DM15PD_06930	COG1674	ftsk spoiiie
DM15PD_06960	COG0778	Nitroreductase
DM15PD_06970	COG0131	Imidazoleglycerol-phosphate dehydratase
DM15PD_06980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DM15PD_06990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DM15PD_07000	COG0107	imidazoleglycerol-phosphate synthase activity
DM15PD_07010	COG0140	phosphoribosyl-ATP diphosphatase activity
DM15PD_07050	COG0753	catalase activity
DM15PD_07100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DM15PD_07180	COG0723	plastoquinol--plastocyanin reductase activity
DM15PD_07190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DM15PD_07210	COG0667	Aldo Keto reductase
DM15PD_07220	COG0745	RESPONSE REGULATOR receiver
DM15PD_07270	COG1643	Atp-dependent helicase
DM15PD_07290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DM15PD_07310	COG2814	Major facilitator Superfamily
DM15PD_07360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DM15PD_07370	COG0717	Belongs to the dCTP deaminase family
DM15PD_07400	COG0438	transferase activity, transferring glycosyl groups
DM15PD_07420	COG0443	Heat shock 70 kDa protein
DM15PD_07430	COG0484	heat shock protein binding
DM15PD_07440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DM15PD_07450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DM15PD_07460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DM15PD_07480	COG2086	electron transfer activity
DM15PD_07520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DM15PD_07530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DM15PD_07560	COG0133	tryptophan synthase activity
DM15PD_07570	COG0159	tryptophan synthase activity
DM15PD_07590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DM15PD_07600	COG0285	dihydrofolate synthase activity
DM15PD_07610	COG0305	Participates in initiation and elongation during chromosome replication
DM15PD_07620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DM15PD_07630	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DM15PD_07670	COG2801	Transposase and inactivated derivatives
DM15PD_07680	COG2842	Transposition protein
DM15PD_07790	COG4373	Mu-like prophage FluMu protein gp28
DM15PD_07960	COG4397	Mu-like prophage major head subunit gpT
DM15PD_08010	COG4386	tail sheath protein
DM15PD_08160	COG1902	pentaerythritol trinitrate reductase activity
DM15PD_08180	COG1733	regulation of RNA biosynthetic process
DM15PD_08230	COG2010	Cytochrome c
DM15PD_08230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DM15PD_08240	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DM15PD_08310	COG0668	transmembrane transport
DM15PD_08340	COG1464	Belongs to the NlpA lipoprotein family
DM15PD_08360	COG2011	ABC-type metal ion transport system permease component
DM15PD_08450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DM15PD_08460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DM15PD_08510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DM15PD_08540	COG2329	Antibiotic biosynthesis monooxygenase
DM15PD_08590	COG4974	Belongs to the 'phage' integrase family
DM15PD_08620	COG0753	catalase activity
DM15PD_08660	COG0602	queuosine metabolic process
DM15PD_08670	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DM15PD_08690	COG1063	alcohol dehydrogenase
DM15PD_08700	COG0602	queuosine metabolic process
DM15PD_08710	COG0302	gtp cyclohydrolase
DM15PD_08720	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DM15PD_08720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DM15PD_08730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DM15PD_08740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DM15PD_08740	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DM15PD_08750	COG0405	Gamma-glutamyltransferase
DM15PD_08760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DM15PD_08780	COG0740	serine-type endopeptidase activity
DM15PD_08820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DM15PD_08840	COG4774	siderophore transport
DM15PD_09010	COG0252	asparaginase activity
DM15PD_09030	COG2985	domain, Protein
DM15PD_09080	COG0463	Glycosyl transferase, family 2
DM15PD_09090	COG2814	Major facilitator Superfamily
DM15PD_09100	COG0246	Mannitol dehydrogenase
DM15PD_09110	COG2323	membrane
DM15PD_09140	COG0629	single-stranded DNA binding
DM15PD_09150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DM15PD_09190	COG1054	Belongs to the UPF0176 family
DM15PD_09200	COG5001	Diguanylate cyclase
DM15PD_09200	COG3300	MHYT domain
DM15PD_09240	COG3321	synthase
DM15PD_09240	COG1028	Short-chain dehydrogenase reductase Sdr
DM15PD_09240	COG0604	alcohol dehydrogenase
DM15PD_09250	COG0318	PFAM AMP-dependent synthetase and ligase
DM15PD_09290	COG4232	protein-disulfide reductase activity
DM15PD_09360	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DM15PD_09380	COG0175	sulfate reduction
DM15PD_09390	COG0175	sulfate reduction
DM15PD_09410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DM15PD_09420	COG1127	ABC transporter
DM15PD_09460	COG1914	H( )-stimulated, divalent metal cation uptake system
DM15PD_09530	COG2267	carboxylic ester hydrolase activity
DM15PD_09540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DM15PD_09560	COG2207	Transcriptional regulator
DM15PD_09570	COG2217	Heavy metal translocating P-type atpase
DM15PD_09580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DM15PD_09590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DM15PD_09600	COG0194	GDP metabolic process
DM15PD_09610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DM15PD_09620	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DM15PD_09640	COG0535	radical SAM domain protein
DM15PD_09650	COG1442	glycosyl transferase family 8
DM15PD_09660	COG1442	glycosyl transferase family 8
DM15PD_09670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DM15PD_09680	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DM15PD_09680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DM15PD_09690	COG0307	riboflavin synthase, alpha
DM15PD_09700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM15PD_09700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM15PD_09720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM15PD_09720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM15PD_09740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DM15PD_09750	COG3047	cAMP biosynthetic process
DM15PD_09780	COG1538	Outer membrane efflux protein
DM15PD_09800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DM15PD_09840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DM15PD_09850	COG0424	maF-like protein
DM15PD_09870	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DM15PD_09890	COG0656	L-ascorbic acid biosynthetic process
DM15PD_09920	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DM15PD_09930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM15PD_09960	COG0420	3'-5' exonuclease activity
DM15PD_09970	COG4717	serine-type aminopeptidase activity
DM15PD_09980	COG0326	Molecular chaperone. Has ATPase activity
DM15PD_10000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DM15PD_10030	COG1028	Short-chain dehydrogenase reductase Sdr
DM15PD_10040	COG0534	Mate efflux family protein
DM15PD_10070	COG1981	membrane
DM15PD_10100	COG3210	domain, Protein
DM15PD_10140	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DM15PD_10250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DM15PD_10260	COG0424	maF-like protein
DM15PD_10290	COG3842	ATPase activity
DM15PD_10320	COG1091	dTDP-4-dehydrorhamnose reductase activity
DM15PD_10330	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DM15PD_10370	COG2244	polysaccharide biosynthetic process
DM15PD_10390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DM15PD_10400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DM15PD_10440	COG0357	Ribosomal RNA small subunit methyltransferase G
DM15PD_10450	COG0445	tRNA wobble uridine modification
DM15PD_10460	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DM15PD_10480	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DM15PD_10490	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM15PD_10510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DM15PD_10530	COG0753	catalase activity
DM15PD_10550	COG1194	a g-specific adenine glycosylase
DM15PD_10570	COG0560	Phosphoserine phosphatase
DM15PD_10580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DM15PD_10590	COG0028	Belongs to the TPP enzyme family
DM15PD_10600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DM15PD_10610	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DM15PD_10620	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DM15PD_10630	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DM15PD_10650	COG0509	glycine decarboxylation via glycine cleavage system
DM15PD_10660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DM15PD_10660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DM15PD_10680	COG1940	carbohydrate kinase activity
DM15PD_10700	COG0312	modulator of DNA gyrase
DM15PD_10760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DM15PD_10770	COG0463	Glycosyl transferase, family 2
DM15PD_10780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DM15PD_10790	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DM15PD_10800	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DM15PD_10810	COG0356	it plays a direct role in the translocation of protons across the membrane
DM15PD_10830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DM15PD_10910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DM15PD_10940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DM15PD_10960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DM15PD_10970	COG0193	aminoacyl-tRNA hydrolase activity
DM15PD_10990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DM15PD_11000	COG0799	negative regulation of ribosome biogenesis
DM15PD_11010	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DM15PD_11040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DM15PD_11130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DM15PD_11140	COG1959	2 iron, 2 sulfur cluster binding
DM15PD_11150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DM15PD_11150	COG1648	precorrin-2 dehydrogenase activity
DM15PD_11170	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DM15PD_11220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DM15PD_11230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DM15PD_11260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DM15PD_11270	COG0196	riboflavin kinase activity
DM15PD_11280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DM15PD_11290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DM15PD_11310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DM15PD_11320	COG0277	FAD linked oxidase domain protein
DM15PD_11370	COG3180	Ammonia monooxygenase
DM15PD_11400	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DM15PD_11420	COG0191	fructose-bisphosphate aldolase activity
DM15PD_11440	COG0778	Nitroreductase
DM15PD_11470	COG4957	zinc ion binding
DM15PD_11500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DM15PD_11510	COG1396	sequence-specific DNA binding
DM15PD_11560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DM15PD_11580	COG0488	(ABC) transporter
DM15PD_11600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DM15PD_11620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DM15PD_11630	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DM15PD_11640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DM15PD_11650	COG0552	protein localization to endoplasmic reticulum
DM15PD_11660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DM15PD_11670	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DM15PD_11680	COG2226	methyltransferase
DM15PD_11690	COG0513	Belongs to the DEAD box helicase family
DM15PD_11700	COG4221	oxidoreductase activity
DM15PD_11710	COG1678	Uncharacterized ACR, COG1678
DM15PD_11810	COG1064	alcohol dehydrogenase
DM15PD_11820	COG1764	response to oxidative stress
DM15PD_11830	COG1064	alcohol dehydrogenase
DM15PD_11840	COG2943	transferase activity, transferring hexosyl groups
DM15PD_11850	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DM15PD_11860	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DM15PD_11860	COG4106	trans-aconitate 2-methyltransferase activity
DM15PD_11870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DM15PD_11870	COG4106	trans-aconitate 2-methyltransferase activity
DM15PD_11890	COG0156	8-amino-7-oxononanoate synthase activity
DM15PD_11950	COG0697	spore germination
DM15PD_11990	COG1216	Glycosyl transferase, family 2
DM15PD_12010	COG0297	glycogen (starch) synthase activity
DM15PD_12030	COG0783	Belongs to the Dps family
DM15PD_12040	COG1216	Glycosyl transferase, family 2
DM15PD_12040	COG0438	transferase activity, transferring glycosyl groups
DM15PD_12060	COG0581	inorganic phosphate transmembrane transporter activity
DM15PD_12070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DM15PD_12100	COG0741	lytic transglycosylase activity
DM15PD_12110	COG1309	transcriptional regulator
DM15PD_12120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM15PD_12190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DM15PD_12210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DM15PD_12220	COG2945	thiolester hydrolase activity
DM15PD_12250	COG0482	sulfurtransferase activity
DM15PD_12290	COG0583	DNA-binding transcription factor activity
DM15PD_12340	COG2995	paraquat-inducible protein a
DM15PD_12350	COG3008	intermembrane lipid transfer
DM15PD_12380	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DM15PD_12410	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DM15PD_12420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DM15PD_12430	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DM15PD_12440	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DM15PD_12450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DM15PD_12580	COG1686	Belongs to the peptidase S11 family
DM15PD_12590	COG0024	Methionine aminopeptidase
DM15PD_12620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DM15PD_12630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DM15PD_12670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DM15PD_12680	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DM15PD_12690	COG0539	negative regulation of cytoplasmic translation
DM15PD_12710	COG1216	Glycosyl transferase, family 2
DM15PD_12730	COG0612	Peptidase, M16
DM15PD_12750	COG1216	Glycosyl transferase, family 2
DM15PD_12770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DM15PD_12810	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DM15PD_12820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DM15PD_12850	COG0745	RESPONSE REGULATOR receiver
DM15PD_12860	COG2205	protein histidine kinase activity
DM15PD_12870	COG1660	Displays ATPase and GTPase activities
DM15PD_12880	COG2814	Major facilitator Superfamily
DM15PD_12890	COG2814	Major facilitator Superfamily
DM15PD_12910	COG3264	Mechanosensitive ion channel
DM15PD_12910	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DM15PD_12920	COG0167	dihydroorotate dehydrogenase activity
DM15PD_12970	COG2204	response regulator
DM15PD_12990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DM15PD_13000	COG0659	secondary active sulfate transmembrane transporter activity
DM15PD_13030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DM15PD_13040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DM15PD_13050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DM15PD_13100	COG2983	Belongs to the UPF0260 family
DM15PD_13150	COG1566	PFAM secretion protein HlyD family protein
DM15PD_13210	COG3104	oligopeptide transport
DM15PD_13220	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DM15PD_13230	COG1217	gtp-binding protein TYPA
DM15PD_13250	COG0492	ferredoxin-NADP+ reductase activity
DM15PD_13270	COG0802	atpase or kinase
DM15PD_13280	COG2887	Belongs to the helicase family. UvrD subfamily
DM15PD_13290	COG1074	ATP-dependent DNA helicase activity
DM15PD_13310	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DM15PD_13340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DM15PD_13350	COG3394	polysaccharide catabolic process
DM15PD_13390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DM15PD_13400	COG1253	flavin adenine dinucleotide binding
DM15PD_13430	COG1393	Belongs to the ArsC family
DM15PD_13440	COG1113	amino acid transport
DM15PD_13490	COG0126	phosphoglycerate kinase activity
DM15PD_13510	COG0564	pseudouridine synthase activity
DM15PD_13530	COG0640	Transcriptional regulator
DM15PD_13540	COG1902	pentaerythritol trinitrate reductase activity
DM15PD_13550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DM15PD_13620	COG1368	sulfuric ester hydrolase activity
DM15PD_13630	COG1596	polysaccharide export
DM15PD_13740	COG2076	Multidrug Resistance protein
DM15PD_13760	COG0656	L-ascorbic acid biosynthetic process
DM15PD_13770	COG0187	DNA topoisomerase II activity
DM15PD_13800	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DM15PD_13800	COG2885	chlorophyll binding
DM15PD_13820	COG0793	Belongs to the peptidase S41A family
DM15PD_13830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DM15PD_13840	COG0758	DNA mediated transformation
DM15PD_13850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DM15PD_13860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DM15PD_13870	COG0540	Belongs to the ATCase OTCase family
DM15PD_13880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DM15PD_13900	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DM15PD_13910	COG1132	(ABC) transporter
DM15PD_13930	COG0019	diaminopimelate decarboxylase activity
DM15PD_13940	COG1295	ribonuclease BN
DM15PD_13950	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DM15PD_13960	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DM15PD_13980	COG0439	Biotin carboxylase
DM15PD_14000	COG4133	protoheme IX ABC transporter activity
DM15PD_14010	COG1126	abc transporter atp-binding protein
DM15PD_14020	COG0765	amino acid transport
DM15PD_14050	COG0542	response to heat
DM15PD_14070	COG0779	Required for maturation of 30S ribosomal subunits
DM15PD_14100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DM15PD_14110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DM15PD_14120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DM15PD_14130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DM15PD_14140	COG1185	polyribonucleotide nucleotidyltransferase activity
DM15PD_14170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DM15PD_14180	COG3158	transport of potassium into the cell
DM15PD_14190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DM15PD_14250	COG0667	Aldo Keto reductase
DM15PD_14300	COG1203	CRISPR-associated helicase, Cas3
DM15PD_14330	COG1857	crispr-associated protein
DM15PD_14360	COG1518	maintenance of DNA repeat elements
DM15PD_14370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DM15PD_14430	COG1028	Short-chain dehydrogenase reductase Sdr
DM15PD_14440	COG2814	Major facilitator Superfamily
DM15PD_14450	COG2376	Dihydroxyacetone kinase
DM15PD_14460	COG0698	ribose 5-phosphate isomerase
DM15PD_14480	COG1113	amino acid transport
DM15PD_14490	COG2175	clavaminate synthase activity
DM15PD_14500	COG0523	cobalamin synthesis protein
DM15PD_14590	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DM15PD_14610	COG0156	8-amino-7-oxononanoate synthase activity
DM15PD_14640	COG0140	phosphoribosyl-ATP diphosphatase activity
DM15PD_14660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DM15PD_14670	COG2814	Major facilitator Superfamily
DM15PD_14680	COG0114	fumarate hydratase activity
DM15PD_14690	COG0281	malic enzyme
DM15PD_14720	COG3088	subunit of a heme lyase
DM15PD_14730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DM15PD_14740	COG1138	Cytochrome C-type biogenesis protein
DM15PD_14750	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DM15PD_14810	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DM15PD_14830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DM15PD_14850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DM15PD_14860	COG0564	pseudouridine synthase activity
DM15PD_14890	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DM15PD_14890	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DM15PD_14900	COG2967	ApaG domain
DM15PD_14950	COG1252	NADH dehydrogenase
DM15PD_14960	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DM15PD_14970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DM15PD_14980	COG0653	protein targeting
DM15PD_14990	COG0217	transcriptional regulatory protein
DM15PD_15000	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DM15PD_15010	COG0632	four-way junction helicase activity
DM15PD_15020	COG2255	four-way junction helicase activity
DM15PD_15030	COG0824	Thioesterase
DM15PD_15050	COG0848	biopolymer transport protein
DM15PD_15070	COG0823	Involved in the tonB-independent uptake of proteins
DM15PD_15080	COG2885	chlorophyll binding
DM15PD_15100	COG0037	tRNA processing
DM15PD_15120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DM15PD_15160	COG2309	aminopeptidase activity
DM15PD_15180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DM15PD_15210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DM15PD_15220	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DM15PD_15230	COG0561	phosphatase activity
DM15PD_15240	COG0363	glucosamine-6-phosphate deaminase activity
DM15PD_15250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DM15PD_15260	COG3265	gluconokinase activity
DM15PD_15290	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DM15PD_15300	COG0697	spore germination
DM15PD_15310	COG0371	Dehydrogenase
DM15PD_15320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DM15PD_15330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DM15PD_15360	COG1028	Short-chain dehydrogenase reductase Sdr
DM15PD_15370	COG2423	ornithine cyclodeaminase activity
DM15PD_15420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DM15PD_15420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DM15PD_15460	COG1570	exodeoxyribonuclease VII activity
DM15PD_15480	COG1530	ribonuclease E activity
DM15PD_15490	COG0860	N-Acetylmuramoyl-L-alanine amidase
DM15PD_15500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DM15PD_15510	COG0730	response to heat
DM15PD_15550	COG0768	penicillin binding
DM15PD_15560	COG0772	Belongs to the SEDS family
DM15PD_15580	COG0751	glycine-tRNA ligase activity
DM15PD_15590	COG0752	glycyl-tRNA synthetase alpha subunit
DM15PD_15620	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DM15PD_15640	COG0316	Belongs to the HesB IscA family
DM15PD_15660	COG0018	arginyl-trna synthetase
DM15PD_15690	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DM15PD_15700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DM15PD_15710	COG0805	protein transport
DM15PD_15720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DM15PD_15770	COG1289	transmembrane transporter activity
DM15PD_15790	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DM15PD_15820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DM15PD_15840	COG0215	cysteine-tRNA ligase activity
DM15PD_15860	COG2814	Major facilitator Superfamily
DM15PD_15870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DM15PD_15880	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DM15PD_15910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DM15PD_15930	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DM15PD_15930	COG2885	chlorophyll binding
DM15PD_15940	COG2885	chlorophyll binding
DM15PD_15940	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DM15PD_15950	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DM15PD_15970	COG4974	Belongs to the 'phage' integrase family
DM15PD_15980	COG0825	malonyl-CoA metabolic process
DM15PD_15990	COG1058	Belongs to the CinA family
DM15PD_15990	COG1546	Belongs to the CinA family
DM15PD_16010	COG0494	nUDIX hydrolase
DM15PD_16030	COG1862	Preprotein translocase
DM15PD_16040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DM15PD_16070	COG1758	RNA polymerase activity
DM15PD_16090	COG0736	holo-[acyl-carrier-protein] synthase activity
DM15PD_16100	COG0681	Belongs to the peptidase S26 family
DM15PD_16120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DM15PD_16130	COG0528	UMP kinase activity
DM15PD_16140	COG0233	cytoplasmic translational termination
DM15PD_16150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DM15PD_16170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DM15PD_16190	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DM15PD_16210	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DM15PD_16220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DM15PD_16240	COG3494	Protein of unknown function (DUF1009)
DM15PD_16250	COG0346	lactoylglutathione lyase activity
DM15PD_16270	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DM15PD_16280	COG0594	ribonuclease P activity
DM15PD_16290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DM15PD_16300	COG0706	membrane insertase activity
DM15PD_16310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DM15PD_16320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DM15PD_16340	COG2171	N-acyltransferase activity
DM15PD_16350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DM15PD_16360	COG0101	tRNA pseudouridine synthase activity
DM15PD_16370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DM15PD_16380	COG0242	peptide deformylase activity
DM15PD_16410	COG1137	ATPase activity
DM15PD_16440	COG0517	IMP dehydrogenase activity
DM15PD_16440	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DM15PD_16500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DM15PD_16520	COG0556	nucleotide-excision repair
DM15PD_16550	COG0189	ligase activity
DM15PD_16590	COG0109	protoheme IX farnesyltransferase activity
DM15PD_16630	COG0312	modulator of DNA gyrase
DM15PD_16640	COG0612	Peptidase, M16
DM15PD_16670	COG0457	Tetratricopeptide repeat
DM15PD_16670	COG0859	PFAM glycosyl transferase family 9
DM15PD_16700	COG4774	siderophore transport
DM15PD_16710	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DM15PD_16720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DM15PD_16740	COG0386	Belongs to the glutathione peroxidase family
DM15PD_16750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DM15PD_16760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DM15PD_16770	COG0181	hydroxymethylbilane synthase activity
DM15PD_16790	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DM15PD_16810	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DM15PD_16850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM15PD_16860	COG1120	ATPase activity
DM15PD_16880	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DM15PD_16890	COG0412	Dienelactone hydrolase
DM15PD_16900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DM15PD_16910	COG0459	protein refolding
DM15PD_16920	COG1199	ATP-dependent helicase activity
DM15PD_16940	COG0392	lysyltransferase activity
DM15PD_16960	COG0670	Belongs to the BI1 family
DM15PD_17000	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DM15PD_17040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DM15PD_17080	COG0628	permease
DM15PD_17090	COG0488	(ABC) transporter
DM15PD_17100	COG0105	UTP biosynthetic process
DM15PD_17110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DM15PD_17120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DM15PD_17130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DM15PD_17140	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DM15PD_17150	COG0248	Ppx GppA phosphatase
DM15PD_17170	COG0019	diaminopimelate decarboxylase activity
DM15PD_17220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DM15PD_17220	COG0519	Catalyzes the synthesis of GMP from XMP
DM15PD_17240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DM15PD_17250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DM15PD_17340	COG0469	pyruvate kinase activity
DM15PD_17350	COG0287	Prephenate dehydrogenase
DM15PD_17370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DM15PD_17380	COG1215	transferase activity, transferring glycosyl groups
DM15PD_17390	COG1562	ergosterol biosynthetic process
DM15PD_17400	COG1562	ergosterol biosynthetic process
DM15PD_17410	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DM15PD_17420	COG1657	PFAM Prenyltransferase squalene oxidase
DM15PD_17430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DM15PD_17440	COG0052	Belongs to the universal ribosomal protein uS2 family
DM15PD_17450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DM15PD_17460	COG1381	Involved in DNA repair and RecF pathway recombination
DM15PD_17480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DM15PD_17490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DM15PD_17510	COG0626	cystathionine gamma-synthase activity
DM15PD_17520	COG0436	Aminotransferase
DM15PD_17540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DM15PD_17560	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DM15PD_17570	COG0077	Prephenate dehydratase
DM15PD_17570	COG1605	Chorismate mutase
DM15PD_17580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DM15PD_17590	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DM15PD_17610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DM15PD_17620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DM15PD_17640	COG1017	nitric oxide dioxygenase activity
DM15PD_17640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DM15PD_17650	COG1959	2 iron, 2 sulfur cluster binding
DM15PD_17660	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DM15PD_17720	COG0745	RESPONSE REGULATOR receiver
DM15PD_17730	COG0708	Exodeoxyribonuclease III
DM15PD_17750	COG0322	excinuclease ABC activity
DM15PD_17780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DM15PD_17800	COG0148	phosphopyruvate hydratase activity
DM15PD_17820	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DM15PD_17830	COG0504	CTP synthase activity
DM15PD_17840	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DM15PD_17850	COG0149	triose-phosphate isomerase activity
DM15PD_17870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DM15PD_17880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DM15PD_17890	COG0134	indole-3-glycerol-phosphate synthase activity
DM15PD_17900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DM15PD_17910	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM15PD_17910	COG0022	dehydrogenase e1 component
DM15PD_17920	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM15PD_17930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DM15PD_17940	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DM15PD_17950	COG2867	negative regulation of translational initiation
DM15PD_18000	COG1216	Glycosyl transferase, family 2
DM15PD_18010	COG1216	Glycosyl transferase, family 2
DM15PD_18010	COG1442	glycosyl transferase family 8
DM15PD_18030	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM15PD_18050	COG1338	Plays a role in the flagellum-specific transport system
DM15PD_18070	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM15PD_18090	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM15PD_18100	COG1766	The M ring may be actively involved in energy transduction
DM15PD_18140	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DM15PD_18160	COG4786	Flagellar basal body rod
DM15PD_18170	COG4786	Flagellar basal body rod
DM15PD_18210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DM15PD_18260	COG1192	Involved in chromosome partitioning
DM15PD_18270	COG1475	DNA binding
DM15PD_18310	COG1558	bacterial-type flagellum-dependent cell motility
DM15PD_18320	COG1815	bacterial-type flagellum-dependent cell motility
DM15PD_18350	COG1677	Flagellar hook-basal body complex protein FliE
DM15PD_18380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM15PD_18390	COG1749	Flagellar hook protein flgE
DM15PD_18430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DM15PD_18440	COG1360	Flagellar Motor Protein
DM15PD_18520	COG1706	bacterial-type flagellum-dependent cell motility