locus-tag	class	description
HN018_00005	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HN018_00015	COG2079	MmgE PrpD family protein
HN018_00035	COG3191	aminopeptidase activity
HN018_00040	COG2205	protein histidine kinase activity
HN018_00045	COG0745	RESPONSE REGULATOR receiver
HN018_00050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HN018_00055	COG0443	Heat shock 70 kDa protein
HN018_00060	COG0484	heat shock protein binding
HN018_00065	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HN018_00070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HN018_00075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HN018_00085	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN018_00090	COG0628	permease
HN018_00130	COG0438	transferase activity, transferring glycosyl groups
HN018_00130	COG1216	Glycosyl transferase, family 2
HN018_00140	COG1657	PFAM Prenyltransferase squalene oxidase
HN018_00145	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HN018_00150	COG1562	ergosterol biosynthetic process
HN018_00155	COG1562	ergosterol biosynthetic process
HN018_00165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN018_00180	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_00185	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_00195	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_00200	COG1129	ABC transporter
HN018_00205	COG1879	ABC-type sugar transport system periplasmic component
HN018_00210	COG2140	Oxalate decarboxylase
HN018_00215	COG0800	Aldolase
HN018_00225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_00230	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HN018_00235	COG1737	Transcriptional regulator
HN018_00245	COG0287	Prephenate dehydrogenase
HN018_00265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HN018_00270	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HN018_00275	COG0535	radical SAM domain protein
HN018_00280	COG0535	radical SAM domain protein
HN018_00335	COG1215	transferase activity, transferring glycosyl groups
HN018_00350	COG4953	penicillin-binding protein 1C
HN018_00365	COG2983	Belongs to the UPF0260 family
HN018_00380	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HN018_00435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HN018_00440	COG2204	response regulator
HN018_00445	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HN018_00455	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HN018_00475	COG1749	Flagellar hook protein flgE
HN018_00510	COG0542	response to heat
HN018_00550	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HN018_00580	COG1472	Belongs to the glycosyl hydrolase 3 family
HN018_00620	COG0438	transferase activity, transferring glycosyl groups
HN018_00625	COG0463	Glycosyl transferase, family 2
HN018_00635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN018_00645	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HN018_00665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HN018_00670	COG2273	Hydrolase Family 16
HN018_00670	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HN018_00675	COG1216	Glycosyl transferase, family 2
HN018_00680	COG3206	protein involved in exopolysaccharide biosynthesis
HN018_00680	COG0489	protein tyrosine kinase activity
HN018_00685	COG3307	-O-antigen
HN018_00700	COG2199	diguanylate cyclase activity
HN018_00700	COG2200	EAL domain
HN018_00705	COG3436	PFAM IS66 Orf2 family protein
HN018_00765	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HN018_00770	COG0642	Histidine kinase
HN018_00775	COG0745	RESPONSE REGULATOR receiver
HN018_00825	COG0745	RESPONSE REGULATOR receiver
HN018_00830	COG2205	protein histidine kinase activity
HN018_00855	COG0438	transferase activity, transferring glycosyl groups
HN018_00865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HN018_00880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HN018_00885	COG1183	phosphatidylcholine synthase activity
HN018_00925	COG1129	ABC transporter
HN018_00930	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_00935	COG1879	ABC-type sugar transport system periplasmic component
HN018_00945	COG3938	Belongs to the proline racemase family
HN018_00950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HN018_00960	COG0531	amino acid
HN018_00995	COG2814	Major facilitator Superfamily
HN018_01000	COG2211	Major facilitator Superfamily
HN018_01090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HN018_01110	COG2390	Transcriptional regulator
HN018_01120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN018_01125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HN018_01135	COG0747	negative chemotaxis
HN018_01145	COG0601	transmembrane transport
HN018_01160	COG1126	abc transporter atp-binding protein
HN018_01180	COG2072	flavoprotein involved in K transport
HN018_01205	COG0829	nickel cation binding
HN018_01210	COG0831	urea catabolic process
HN018_01215	COG0832	Belongs to the urease beta subunit family
HN018_01220	COG0804	urea catabolic process
HN018_01225	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HN018_01230	COG0830	nickel cation binding
HN018_01235	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HN018_01240	COG2186	Transcriptional regulator
HN018_01245	COG1063	alcohol dehydrogenase
HN018_01250	COG1349	DNA-binding transcription factor activity
HN018_01265	COG1175	transmembrane transport
HN018_01275	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_01295	COG2376	Dihydroxyacetone kinase
HN018_01300	COG0698	ribose 5-phosphate isomerase
HN018_01305	COG0149	triose-phosphate isomerase activity
HN018_01310	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN018_01315	COG1024	Enoyl-CoA hydratase
HN018_01320	COG0633	Ferredoxin
HN018_01325	COG5001	Diguanylate cyclase
HN018_01355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HN018_01360	COG0753	catalase activity
HN018_01365	COG0583	DNA-binding transcription factor activity
HN018_01425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HN018_01440	COG0737	Belongs to the 5'-nucleotidase family
HN018_01450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HN018_01460	COG1216	Glycosyl transferase, family 2
HN018_01460	COG0438	transferase activity, transferring glycosyl groups
HN018_01475	COG0438	transferase activity, transferring glycosyl groups
HN018_01475	COG1216	Glycosyl transferase, family 2
HN018_01485	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HN018_01490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HN018_01525	COG2853	Lipoprotein
HN018_01550	COG0028	Belongs to the TPP enzyme family
HN018_01550	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HN018_01565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HN018_01580	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HN018_01600	COG0284	orotidine-5'-phosphate decarboxylase activity
HN018_01605	COG0135	phosphoribosylanthranilate isomerase activity
HN018_01635	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_01640	COG1129	ABC transporter
HN018_01650	COG1063	alcohol dehydrogenase
HN018_01655	COG1461	Dihydroxyacetone kinase
HN018_01660	COG2376	Dihydroxyacetone kinase
HN018_01665	COG2390	Transcriptional regulator
HN018_01670	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HN018_01680	COG1764	response to oxidative stress
HN018_01685	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HN018_01700	COG0431	NADPH-dependent FMN reductase
HN018_01705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HN018_01725	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HN018_01745	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HN018_01770	COG0515	serine threonine protein kinase
HN018_01770	COG2815	serine threonine protein kinase
HN018_01775	COG2223	nitrite transmembrane transporter activity
HN018_01780	COG0243	molybdopterin cofactor binding
HN018_01790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HN018_01800	COG0443	Heat shock 70 kDa protein
HN018_01820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HN018_01825	COG3047	cAMP biosynthetic process
HN018_01845	COG0741	lytic transglycosylase activity
HN018_01850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HN018_01870	COG3842	ATPase activity
HN018_01875	COG3920	Histidine kinase
HN018_01875	COG2202	Pas domain
HN018_01900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HN018_01905	COG0307	riboflavin synthase, alpha
HN018_01910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HN018_01910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HN018_01915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HN018_01915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HN018_01920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HN018_01935	COG3706	GGDEF domain
HN018_01955	COG1295	ribonuclease BN
HN018_01970	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HN018_02005	COG2814	Major facilitator Superfamily
HN018_02010	COG0596	Alpha beta hydrolase
HN018_02015	COG1573	uracil-dna glycosylase
HN018_02025	COG2942	2-epimerase
HN018_02035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HN018_02050	COG0469	pyruvate kinase activity
HN018_02065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HN018_02070	COG0625	glutathione transferase activity
HN018_02075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HN018_02080	COG0492	ferredoxin-NADP+ reductase activity
HN018_02090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HN018_02095	COG2887	Belongs to the helicase family. UvrD subfamily
HN018_02100	COG1074	ATP-dependent DNA helicase activity
HN018_02105	COG3118	belongs to the thioredoxin family
HN018_02120	COG3394	polysaccharide catabolic process
HN018_02140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HN018_02145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HN018_02155	COG1609	Transcriptional regulator
HN018_02160	COG1129	ABC transporter
HN018_02180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN018_02190	COG0235	Class ii aldolase
HN018_02195	COG2084	Dehydrogenase
HN018_02200	COG3622	Belongs to the hyi family
HN018_02205	COG3395	kinase activity
HN018_02255	COG4964	Belongs to the GSP D family
HN018_02295	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HN018_02300	COG4133	protoheme IX ABC transporter activity
HN018_02315	COG0765	amino acid transport
HN018_02320	COG1846	Transcriptional regulator
HN018_02325	COG1764	response to oxidative stress
HN018_02340	COG1012	belongs to the aldehyde dehydrogenase family
HN018_02350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_02355	COG0779	Required for maturation of 30S ribosomal subunits
HN018_02370	COG5373	membrane
HN018_02370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HN018_02375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HN018_02390	COG4948	Mandelate Racemase Muconate Lactonizing
HN018_02395	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_02400	COG1129	ABC transporter
HN018_02405	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_02420	COG4154	Belongs to the RbsD FucU family
HN018_02425	COG0339	signal peptide processing
HN018_02465	COG0667	Aldo Keto reductase
HN018_02510	COG2205	protein histidine kinase activity
HN018_02525	COG0659	secondary active sulfate transmembrane transporter activity
HN018_02545	COG0778	Nitroreductase
HN018_02580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HN018_02585	COG1396	sequence-specific DNA binding
HN018_02595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HN018_02600	COG1053	succinate dehydrogenase
HN018_02625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HN018_02635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HN018_02650	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HN018_02655	COG0039	L-malate dehydrogenase activity
HN018_02660	COG0567	Dehydrogenase, E1 component
HN018_02665	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN018_02675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HN018_02680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HN018_02685	COG0667	Aldo Keto reductase
HN018_02695	COG0477	Major facilitator Superfamily
HN018_02740	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_02755	COG2010	Cytochrome c
HN018_02755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HN018_02775	COG1309	transcriptional regulator
HN018_02785	COG2995	paraquat-inducible protein a
HN018_02790	COG3008	intermembrane lipid transfer
HN018_02940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HN018_02950	COG1609	Transcriptional regulator
HN018_02960	COG1129	ABC transporter
HN018_02970	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_02980	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HN018_02995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HN018_03000	COG0347	Belongs to the P(II) protein family
HN018_03005	COG0004	ammonium transporteR
HN018_03015	COG4771	TonB-dependent receptor
HN018_03025	COG4974	Belongs to the 'phage' integrase family
HN018_03050	COG1506	peptidase
HN018_03050	COG0823	Involved in the tonB-independent uptake of proteins
HN018_03050	COG4946	Tricorn protease homolog
HN018_03060	COG0793	Belongs to the peptidase S41A family
HN018_03060	COG4946	Tricorn protease homolog
HN018_03080	COG3275	phosphorelay sensor kinase activity
HN018_03090	COG2244	polysaccharide biosynthetic process
HN018_03100	COG1105	Belongs to the carbohydrate kinase PfkB family
HN018_03110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HN018_03115	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HN018_03120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HN018_03125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HN018_03130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HN018_03135	COG3706	GGDEF domain
HN018_03135	COG4251	negative regulation of phosphorylation
HN018_03135	COG2203	Gaf domain
HN018_03135	COG5001	Diguanylate cyclase
HN018_03140	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HN018_03150	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HN018_03155	COG0602	queuosine metabolic process
HN018_03165	COG0667	Aldo Keto reductase
HN018_03180	COG0673	inositol 2-dehydrogenase activity
HN018_03200	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HN018_03230	COG0251	oxidation-reduction process
HN018_03250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN018_03265	COG0783	Belongs to the Dps family
HN018_03335	COG2372	response to copper ion
HN018_03355	COG2132	Multicopper oxidase
HN018_03390	COG0583	DNA-binding transcription factor activity
HN018_03395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HN018_03410	COG0601	transmembrane transport
HN018_03415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HN018_03420	COG0444	Belongs to the ABC transporter superfamily
HN018_03425	COG4608	Belongs to the ABC transporter superfamily
HN018_03430	COG2072	flavoprotein involved in K transport
HN018_03440	COG4772	TonB-dependent receptor
HN018_03460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HN018_03510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HN018_03515	COG1349	DNA-binding transcription factor activity
HN018_03520	COG0747	negative chemotaxis
HN018_03530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HN018_03535	COG0444	Belongs to the ABC transporter superfamily
HN018_03540	COG4608	Belongs to the ABC transporter superfamily
HN018_03550	COG0402	S-adenosylhomocysteine deaminase activity
HN018_03560	COG4771	TonB-dependent receptor
HN018_03565	COG1176	ABC-type spermidine putrescine transport system, permease component I
HN018_03570	COG1177	transmembrane transport
HN018_03575	COG3842	ATPase activity
HN018_03585	COG4644	lycopene metabolic process
HN018_03610	COG0745	RESPONSE REGULATOR receiver
HN018_03630	COG2124	cytochrome p450
HN018_03630	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HN018_03635	COG2855	membrane
HN018_03640	COG0583	DNA-binding transcription factor activity
HN018_03705	COG3300	MHYT domain
HN018_03705	COG5001	Diguanylate cyclase
HN018_03725	COG1595	DNA-templated transcription, initiation
HN018_03740	COG2706	6-phosphogluconolactonase activity
HN018_03760	COG4584	PFAM Integrase catalytic
HN018_03765	COG1484	DNA-dependent DNA replication
HN018_03780	COG0025	NhaP-type Na H and K H
HN018_03805	COG3059	membrane
HN018_03810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HN018_03835	COG0583	DNA-binding transcription factor activity
HN018_03840	COG4221	oxidoreductase activity
HN018_03840	COG3321	synthase
HN018_03840	COG0604	alcohol dehydrogenase
HN018_03840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN018_03845	COG2826	transposase and inactivated derivatives, IS30 family
HN018_03885	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_03890	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_03890	COG0604	alcohol dehydrogenase
HN018_03890	COG3321	synthase
HN018_03895	COG0596	Alpha beta hydrolase
HN018_03905	COG0583	DNA-binding transcription factor activity
HN018_03910	COG2826	transposase and inactivated derivatives, IS30 family
HN018_03925	COG2826	transposase and inactivated derivatives, IS30 family
HN018_03930	COG4206	TonB-dependent receptor
HN018_03940	COG0444	Belongs to the ABC transporter superfamily
HN018_03950	COG0673	inositol 2-dehydrogenase activity
HN018_03965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HN018_03970	COG0601	transmembrane transport
HN018_03980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_04030	COG2826	transposase and inactivated derivatives, IS30 family
HN018_04050	COG0436	Aminotransferase
HN018_04080	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HN018_04085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HN018_04110	COG0583	DNA-binding transcription factor activity
HN018_04130	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HN018_04135	COG0183	Belongs to the thiolase family
HN018_04140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HN018_04150	COG1414	Transcriptional regulator
HN018_04155	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_04180	COG3485	protocatechuate 3,4-dioxygenase
HN018_04190	COG1879	ABC-type sugar transport system periplasmic component
HN018_04195	COG1129	ABC transporter
HN018_04205	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_04210	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_04220	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_04225	COG1063	alcohol dehydrogenase
HN018_04230	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_04240	COG1129	ABC transporter
HN018_04245	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_04255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HN018_04260	COG1609	Transcriptional regulator
HN018_04300	COG1802	Transcriptional regulator
HN018_04305	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_04335	COG0183	Belongs to the thiolase family
HN018_04370	COG1129	ABC transporter
HN018_04375	COG1879	ABC-type sugar transport system periplasmic component
HN018_04385	COG1063	alcohol dehydrogenase
HN018_04400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN018_04405	COG0800	Aldolase
HN018_04450	COG4964	Belongs to the GSP D family
HN018_04480	COG0745	RESPONSE REGULATOR receiver
HN018_04495	COG0604	alcohol dehydrogenase
HN018_04500	COG1309	transcriptional regulator
HN018_04525	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HN018_04535	COG1733	regulation of RNA biosynthetic process
HN018_04540	COG2271	Major facilitator Superfamily
HN018_04550	COG0436	Aminotransferase
HN018_04555	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_04560	COG0435	Glutathione S-transferase
HN018_04580	COG2271	Major facilitator Superfamily
HN018_04595	COG0167	dihydroorotate dehydrogenase activity
HN018_04610	COG1678	Uncharacterized ACR, COG1678
HN018_04620	COG4221	oxidoreductase activity
HN018_04625	COG2326	polyphosphate kinase activity
HN018_04655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HN018_04660	COG1686	Belongs to the peptidase S11 family
HN018_04665	COG0024	Methionine aminopeptidase
HN018_04675	COG0861	Integral membrane protein TerC family
HN018_04680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HN018_04690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HN018_04705	COG0047	phosphoribosylformylglycinamidine synthase activity
HN018_04710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HN018_04730	COG0792	nuclease activity
HN018_04745	COG0628	permease
HN018_04755	COG2897	thiosulfate sulfurtransferase activity
HN018_04760	COG0626	cystathionine gamma-synthase activity
HN018_04775	COG0606	chelatase, subunit chli
HN018_04780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_04785	COG1733	regulation of RNA biosynthetic process
HN018_04800	COG3474	cytochrome
HN018_04815	COG4774	siderophore transport
HN018_04820	COG2816	NAD+ diphosphatase activity
HN018_04835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HN018_04840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HN018_04850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HN018_04855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HN018_04860	COG3546	catalase activity
HN018_04865	COG3685	Protein conserved in bacteria
HN018_04870	COG3161	chorismate lyase activity
HN018_04880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HN018_04885	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HN018_04890	COG0539	negative regulation of cytoplasmic translation
HN018_04905	COG5508	conserved small protein
HN018_04915	COG3088	subunit of a heme lyase
HN018_04920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN018_04925	COG1138	Cytochrome C-type biogenesis protein
HN018_04930	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HN018_04940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HN018_04995	COG2140	Oxalate decarboxylase
HN018_05000	COG0583	DNA-binding transcription factor activity
HN018_05010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HN018_05015	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HN018_05045	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_05070	COG0745	RESPONSE REGULATOR receiver
HN018_05075	COG2205	protein histidine kinase activity
HN018_05090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN018_05100	COG0438	transferase activity, transferring glycosyl groups
HN018_05115	COG0438	transferase activity, transferring glycosyl groups
HN018_05120	COG2376	Dihydroxyacetone kinase
HN018_05125	COG1129	ABC transporter
HN018_05130	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_05135	COG1879	ABC-type sugar transport system periplasmic component
HN018_05140	COG1349	DNA-binding transcription factor activity
HN018_05145	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_05155	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HN018_05160	COG0081	regulation of translation
HN018_05165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HN018_05170	COG0222	ribosome binding
HN018_05175	COG0085	RNA polymerase activity
HN018_05180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HN018_05185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HN018_05190	COG0049	tRNA binding
HN018_05195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HN018_05200	COG0051	transcription antitermination factor activity, RNA binding
HN018_05205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HN018_05210	COG0088	Forms part of the polypeptide exit tunnel
HN018_05215	COG0089	rRNA binding
HN018_05220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HN018_05225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HN018_05230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HN018_05235	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HN018_05240	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HN018_05245	COG0255	Belongs to the universal ribosomal protein uL29 family
HN018_05250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HN018_05255	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HN018_05260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HN018_05265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HN018_05270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HN018_05275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HN018_05280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HN018_05285	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HN018_05290	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HN018_05295	COG1841	ribosomal large subunit assembly
HN018_05300	COG0200	Binds to the 23S rRNA
HN018_05305	COG0201	protein transport
HN018_05310	COG0563	adenylate kinase activity
HN018_05315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HN018_05320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HN018_05325	COG0202	RNA polymerase activity
HN018_05330	COG0203	ribosomal protein L17
HN018_05340	COG0330	HflC and HflK could
HN018_05360	COG5487	UPF0391 membrane protein
HN018_05380	COG1691	(AIR) carboxylase
HN018_05390	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HN018_05395	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HN018_05405	COG0656	L-ascorbic acid biosynthetic process
HN018_05420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HN018_05425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HN018_05430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN018_05445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HN018_05450	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HN018_05470	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HN018_05490	COG0714	Associated with various cellular activities
HN018_05520	COG2175	clavaminate synthase activity
HN018_05530	COG1132	(ABC) transporter
HN018_05545	COG2814	Major facilitator Superfamily
HN018_05555	COG0300	oxidoreductase activity
HN018_05560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HN018_05565	COG1295	ribonuclease BN
HN018_05575	COG1051	belongs to the nudix hydrolase family
HN018_05585	COG0793	Belongs to the peptidase S41A family
HN018_05595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HN018_05605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN018_05620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HN018_05635	COG1116	anion transmembrane transporter activity
HN018_05640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HN018_05655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HN018_05660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HN018_05665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HN018_05675	COG0505	Belongs to the CarA family
HN018_05690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HN018_05735	COG1285	pathogenesis
HN018_05740	COG0625	glutathione transferase activity
HN018_05745	COG0360	Binds together with S18 to 16S ribosomal RNA
HN018_05750	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HN018_05755	COG0359	binds to the 23S rRNA
HN018_05760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HN018_05765	COG0584	glycerophosphoryl diester phosphodiesterase
HN018_05795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HN018_05800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HN018_05820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HN018_05830	COG0633	Ferredoxin
HN018_05830	COG3217	Mosc domain protein beta barrel domain protein
HN018_05845	COG0009	L-threonylcarbamoyladenylate synthase
HN018_05855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HN018_05880	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HN018_05885	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HN018_05890	COG1797	cobyrinic acid a,c-diamide synthase activity
HN018_05895	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HN018_05975	COG0583	DNA-binding transcription factor activity
HN018_05995	COG1492	cobalamin metabolic process
HN018_06010	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HN018_06020	COG3706	GGDEF domain
HN018_06035	COG0463	Glycosyl transferase, family 2
HN018_06045	COG0656	L-ascorbic acid biosynthetic process
HN018_06070	COG0649	NAD binding
HN018_06075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_06080	COG1183	phosphatidylcholine synthase activity
HN018_06085	COG0688	phosphatidylethanolamine metabolic process
HN018_06110	COG1064	alcohol dehydrogenase
HN018_06115	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HN018_06125	COG4774	siderophore transport
HN018_06135	COG1294	oxidase, subunit
HN018_06140	COG1271	oxidase subunit
HN018_06190	COG1349	DNA-binding transcription factor activity
HN018_06195	COG2223	nitrite transmembrane transporter activity
HN018_06220	COG0438	transferase activity, transferring glycosyl groups
HN018_06240	COG0745	RESPONSE REGULATOR receiver
HN018_06245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HN018_06250	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HN018_06255	COG2814	Major facilitator Superfamily
HN018_06260	COG1566	PFAM secretion protein HlyD family protein
HN018_06290	COG1872	DUF167
HN018_06295	COG0556	nucleotide-excision repair
HN018_06305	COG1942	4-Oxalocrotonate Tautomerase
HN018_06315	COG0384	phenazine biosynthesis protein PhzF
HN018_06320	COG2017	converts alpha-aldose to the beta-anomer
HN018_06335	COG0823	Involved in the tonB-independent uptake of proteins
HN018_06335	COG1506	peptidase
HN018_06355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HN018_06360	COG0109	protoheme IX farnesyltransferase activity
HN018_06375	COG0312	modulator of DNA gyrase
HN018_06380	COG0612	Peptidase, M16
HN018_06405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HN018_06410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HN018_06425	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_06445	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HN018_06485	COG0438	transferase activity, transferring glycosyl groups
HN018_06485	COG1216	Glycosyl transferase, family 2
HN018_06495	COG0321	lipoyl(octanoyl) transferase activity
HN018_06530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HN018_06535	COG2201	protein-glutamate methylesterase activity
HN018_06540	COG0745	RESPONSE REGULATOR receiver
HN018_06550	COG2198	Histidine kinase
HN018_06550	COG0784	Response regulator, receiver
HN018_06550	COG0643	Histidine kinase
HN018_06560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HN018_06575	COG1040	competence protein
HN018_06580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HN018_06615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HN018_06620	COG0124	histidyl-tRNA synthetase
HN018_06625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HN018_06645	COG2890	protein-(glutamine-N5) methyltransferase activity
HN018_06665	COG0582	viral genome integration into host DNA
HN018_06750	COG3750	Belongs to the UPF0335 family
HN018_06800	COG4974	Belongs to the 'phage' integrase family
HN018_06835	COG4626	Terminase
HN018_06835	COG1802	Transcriptional regulator
HN018_06840	COG4695	Portal protein
HN018_07040	COG1253	flavin adenine dinucleotide binding
HN018_07050	COG2135	peptidase activity
HN018_07070	COG0473	3-isopropylmalate dehydrogenase activity
HN018_07075	COG0006	proline dipeptidase activity
HN018_07090	COG2264	protein methyltransferase activity
HN018_07095	COG0210	DNA helicase
HN018_07110	COG3791	Glutathione-dependent formaldehyde-activating
HN018_07130	COG0489	protein tyrosine kinase activity
HN018_07150	COG2003	Belongs to the UPF0758 family
HN018_07155	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HN018_07160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HN018_07185	COG0254	rRNA binding
HN018_07195	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HN018_07200	COG1970	mechanosensitive ion channel activity
HN018_07215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HN018_07220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HN018_07225	COG0673	inositol 2-dehydrogenase activity
HN018_07235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HN018_07260	COG2144	transferase activity, transferring acyl groups
HN018_07265	COG0438	transferase activity, transferring glycosyl groups
HN018_07275	COG2072	flavoprotein involved in K transport
HN018_07290	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HN018_07295	COG1640	4-alpha-glucanotransferase
HN018_07300	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HN018_07310	COG0366	Alpha amylase catalytic
HN018_07315	COG0784	Response regulator, receiver
HN018_07340	COG4988	ABC transporter
HN018_07345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HN018_07360	COG0667	Aldo Keto reductase
HN018_07385	COG3842	ATPase activity
HN018_07390	COG3842	ATPase activity
HN018_07395	COG1175	transmembrane transport
HN018_07400	COG0395	ABC-type sugar transport system, permease component
HN018_07415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HN018_07440	COG2205	protein histidine kinase activity
HN018_07445	COG0745	RESPONSE REGULATOR receiver
HN018_07465	COG1129	ABC transporter
HN018_07470	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_07475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HN018_07480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HN018_07485	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HN018_07525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HN018_07540	COG0525	valine-tRNA ligase activity
HN018_07545	COG0129	dihydroxy-acid dehydratase activity
HN018_07555	COG3511	phospholipase C
HN018_07575	COG2080	2 iron, 2 sulfur cluster binding
HN018_07580	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HN018_07585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HN018_07595	COG0542	response to heat
HN018_07605	COG0501	Belongs to the peptidase M48B family
HN018_07625	COG0129	dihydroxy-acid dehydratase activity
HN018_07635	COG1129	ABC transporter
HN018_07655	COG0800	Aldolase
HN018_07660	COG3734	2-keto-3-deoxy-galactonokinase
HN018_07665	COG2186	Transcriptional regulator
HN018_07680	COG0662	Cupin 2, conserved barrel domain protein
HN018_07690	COG0438	transferase activity, transferring glycosyl groups
HN018_07695	COG1132	(ABC) transporter
HN018_07700	COG1802	Transcriptional regulator
HN018_07705	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HN018_07715	COG0850	regulation of cytokinetic process
HN018_07725	COG2081	HI0933 family
HN018_07740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN018_07760	COG2116	formate transmembrane transporter activity
HN018_07800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HN018_07805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HN018_07825	COG0446	pyridine nucleotide-disulphide oxidoreductase
HN018_07845	COG0752	glycyl-tRNA synthetase alpha subunit
HN018_07850	COG1832	CoA-binding protein
HN018_07870	COG4251	negative regulation of phosphorylation
HN018_07875	COG0784	Response regulator, receiver
HN018_07880	COG4191	Histidine kinase
HN018_07880	COG0784	Response regulator, receiver
HN018_07890	COG0655	NAD(P)H dehydrogenase (quinone) activity
HN018_07895	COG3920	Histidine kinase
HN018_07895	COG2202	Pas domain
HN018_07905	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HN018_07915	COG3387	PFAM Glycoside hydrolase 15-related
HN018_07930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HN018_07965	COG2885	chlorophyll binding
HN018_07965	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HN018_07970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HN018_07980	COG4974	Belongs to the 'phage' integrase family
HN018_07985	COG0825	malonyl-CoA metabolic process
HN018_08000	COG1546	Belongs to the CinA family
HN018_08000	COG1058	Belongs to the CinA family
HN018_08005	COG3386	PFAM SMP-30 Gluconolaconase
HN018_08015	COG0667	Aldo Keto reductase
HN018_08020	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_08050	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HN018_08055	COG2205	protein histidine kinase activity
HN018_08060	COG0745	RESPONSE REGULATOR receiver
HN018_08065	COG2814	Major facilitator Superfamily
HN018_08070	COG1335	isochorismatase
HN018_08080	COG2169	Transcriptional regulator
HN018_08080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HN018_08090	COG1420	regulation of RNA biosynthetic process
HN018_08095	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HN018_08100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HN018_08110	COG1185	polyribonucleotide nucleotidyltransferase activity
HN018_08115	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HN018_08120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HN018_08125	COG0494	nUDIX hydrolase
HN018_08135	COG1714	RDD family
HN018_08140	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HN018_08145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HN018_08150	COG0653	protein targeting
HN018_08155	COG0217	transcriptional regulatory protein
HN018_08160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HN018_08175	COG2826	transposase and inactivated derivatives, IS30 family
HN018_08185	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_08190	COG0583	DNA-binding transcription factor activity
HN018_08205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HN018_08220	COG0596	Alpha beta hydrolase
HN018_08235	COG0632	four-way junction helicase activity
HN018_08240	COG2255	four-way junction helicase activity
HN018_08245	COG0824	Thioesterase
HN018_08255	COG0848	biopolymer transport protein
HN018_08265	COG0823	Involved in the tonB-independent uptake of proteins
HN018_08270	COG2885	chlorophyll binding
HN018_08280	COG0037	tRNA processing
HN018_08290	COG1902	pentaerythritol trinitrate reductase activity
HN018_08300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HN018_08305	COG0351	phosphomethylpyrimidine kinase
HN018_08305	COG0352	thiamine-phosphate diphosphorylase activity
HN018_08315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HN018_08320	COG0450	alkyl hydroperoxide reductase
HN018_08330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HN018_08355	COG0483	inositol monophosphate 1-phosphatase activity
HN018_08360	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HN018_08385	COG0352	thiamine-phosphate diphosphorylase activity
HN018_08410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HN018_08415	COG1692	metallophosphoesterase
HN018_08435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HN018_08440	COG0025	NhaP-type Na H and K H
HN018_08455	COG1309	transcriptional regulator
HN018_08475	COG1063	alcohol dehydrogenase
HN018_08480	COG3284	Transcriptional regulator
HN018_08515	COG0596	Alpha beta hydrolase
HN018_08535	COG2244	polysaccharide biosynthetic process
HN018_08540	COG2942	2-epimerase
HN018_08550	COG1216	Glycosyl transferase, family 2
HN018_08570	COG0347	Belongs to the P(II) protein family
HN018_08575	COG0436	Aminotransferase
HN018_08585	COG0746	molybdenum cofactor guanylyltransferase activity
HN018_08595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HN018_08600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HN018_08605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HN018_08615	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HN018_08620	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HN018_08630	COG0740	serine-type endopeptidase activity
HN018_08640	COG0436	Aminotransferase
HN018_08650	COG1494	fructose-1,6-bisphosphatase
HN018_08655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HN018_08680	COG1609	Transcriptional regulator
HN018_08685	COG0673	inositol 2-dehydrogenase activity
HN018_08700	COG1175	transmembrane transport
HN018_08705	COG3833	ABC-type maltose transport systems, permease component
HN018_08715	COG0673	inositol 2-dehydrogenase activity
HN018_08730	COG0438	transferase activity, transferring glycosyl groups
HN018_08785	COG1278	Cold shock
HN018_08795	COG1272	protein, Hemolysin III
HN018_08810	COG1278	Cold shock
HN018_08830	COG5001	Diguanylate cyclase
HN018_08830	COG3300	MHYT domain
HN018_08840	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HN018_08845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HN018_08850	COG0463	Glycosyl transferase, family 2
HN018_08890	COG4771	TonB-dependent receptor
HN018_08895	COG1231	oxidoreductase activity
HN018_08915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HN018_08925	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_08930	COG1879	ABC-type sugar transport system periplasmic component
HN018_08950	COG2308	Evidence 4 Homologs of previously reported genes of
HN018_09050	COG0531	amino acid
HN018_09070	COG1116	anion transmembrane transporter activity
HN018_09080	COG0756	dUTP diphosphatase activity
HN018_09085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HN018_09090	COG2226	methyltransferase
HN018_09095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HN018_09100	COG0268	Binds directly to 16S ribosomal RNA
HN018_09105	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HN018_09115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HN018_09125	COG0697	spore germination
HN018_09150	COG0210	DNA helicase
HN018_09155	COG1058	Belongs to the CinA family
HN018_09155	COG1546	Belongs to the CinA family
HN018_09160	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HN018_09165	COG1879	ABC-type sugar transport system periplasmic component
HN018_09170	COG1129	ABC transporter
HN018_09175	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_09180	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_09195	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_09220	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HN018_09225	COG0551	DNA topoisomerase type I activity
HN018_09225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HN018_09245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HN018_09250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HN018_09255	COG0604	alcohol dehydrogenase
HN018_09255	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_09255	COG3321	synthase
HN018_09300	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_09315	COG0363	glucosamine-6-phosphate deaminase activity
HN018_09340	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_09345	COG3142	Participates in the control of copper homeostasis
HN018_09350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN018_09400	COG1595	DNA-templated transcription, initiation
HN018_09410	COG1309	transcriptional regulator
HN018_09415	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_09430	COG1024	Enoyl-CoA hydratase
HN018_09440	COG0183	Belongs to the thiolase family
HN018_09445	COG0477	Major facilitator Superfamily
HN018_09465	COG0705	Rhomboid family
HN018_09475	COG1940	carbohydrate kinase activity
HN018_09525	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HN018_09555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HN018_09555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HN018_09585	COG0322	excinuclease ABC activity
HN018_09590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HN018_09595	COG1763	Mo-molybdopterin cofactor biosynthetic process
HN018_09605	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HN018_09610	COG0314	molybdopterin synthase activity
HN018_09620	COG0156	8-amino-7-oxononanoate synthase activity
HN018_09630	COG4106	trans-aconitate 2-methyltransferase activity
HN018_09630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HN018_09635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HN018_09640	COG0303	'Molybdopterin
HN018_09645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HN018_09660	COG0148	phosphopyruvate hydratase activity
HN018_09670	COG2272	Belongs to the type-B carboxylesterase lipase family
HN018_09680	COG0243	molybdopterin cofactor binding
HN018_09685	COG3665	Urea carboxylase-associated protein
HN018_09695	COG0545	Peptidyl-prolyl cis-trans isomerase
HN018_09705	COG0504	CTP synthase activity
HN018_09720	COG0149	triose-phosphate isomerase activity
HN018_09730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HN018_09740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HN018_09745	COG0134	indole-3-glycerol-phosphate synthase activity
HN018_09750	COG0315	cyclic pyranopterin monophosphate synthase activity
HN018_09755	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HN018_09760	COG0022	dehydrogenase e1 component
HN018_09760	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN018_09765	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN018_09770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HN018_09775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HN018_09780	COG2867	negative regulation of translational initiation
HN018_09795	COG1058	Belongs to the CinA family
HN018_09795	COG1546	Belongs to the CinA family
HN018_09800	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HN018_09810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HN018_09815	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HN018_09820	COG0443	Heat shock 70 kDa protein
HN018_09825	COG1573	uracil-dna glycosylase
HN018_09835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HN018_09840	COG0745	RESPONSE REGULATOR receiver
HN018_09850	COG1758	RNA polymerase activity
HN018_09860	COG0736	holo-[acyl-carrier-protein] synthase activity
HN018_09865	COG0681	Belongs to the peptidase S26 family
HN018_09870	COG0571	ribonuclease III activity
HN018_09880	COG0528	UMP kinase activity
HN018_09885	COG0233	cytoplasmic translational termination
HN018_09890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HN018_09900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HN018_09905	COG0750	zinc metalloprotease
HN018_09910	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HN018_09920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN018_09925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HN018_09930	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN018_09940	COG0346	lactoylglutathione lyase activity
HN018_09950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HN018_09955	COG0594	ribonuclease P activity
HN018_09965	COG0706	membrane insertase activity
HN018_09970	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HN018_09975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HN018_09985	COG3706	GGDEF domain
HN018_09990	COG2171	N-acyltransferase activity
HN018_09995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HN018_10005	COG0101	tRNA pseudouridine synthase activity
HN018_10010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HN018_10015	COG0242	peptide deformylase activity
HN018_10030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HN018_10035	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HN018_10040	COG1137	ATPase activity
HN018_10090	COG0306	phosphate transporter
HN018_10100	COG1742	UPF0060 membrane protein
HN018_10105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HN018_10110	COG2186	Transcriptional regulator
HN018_10115	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_10120	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_10125	COG1129	ABC transporter
HN018_10130	COG1879	ABC-type sugar transport system periplasmic component
HN018_10140	COG0708	Exodeoxyribonuclease III
HN018_10145	COG0316	Belongs to the HesB IscA family
HN018_10150	COG0018	arginyl-trna synthetase
HN018_10165	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HN018_10170	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HN018_10175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HN018_10180	COG0805	protein transport
HN018_10185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HN018_10190	COG1216	Glycosyl transferase, family 2
HN018_10190	COG0438	transferase activity, transferring glycosyl groups
HN018_10210	COG1862	Preprotein translocase
HN018_10225	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_10250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HN018_10255	COG0629	single-stranded DNA binding
HN018_10260	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HN018_10265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HN018_10290	COG0450	alkyl hydroperoxide reductase
HN018_10305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN018_10305	COG3453	Protein conserved in bacteria
HN018_10340	COG0424	maF-like protein
HN018_10345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HN018_10350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HN018_10355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HN018_10360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HN018_10365	COG0717	Belongs to the dCTP deaminase family
HN018_10385	COG1538	Outer membrane efflux protein
HN018_10425	COG1609	Transcriptional regulator
HN018_10450	COG1063	alcohol dehydrogenase
HN018_10455	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_10460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HN018_10465	COG0617	tRNA 3'-terminal CCA addition
HN018_10465	COG0517	IMP dehydrogenase activity
HN018_10465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HN018_10470	COG1007	ATP synthesis coupled electron transport
HN018_10485	COG0713	ATP synthesis coupled electron transport
HN018_10490	COG0839	Belongs to the complex I subunit 6 family
HN018_10495	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_10500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HN018_10505	COG1034	ATP synthesis coupled electron transport
HN018_10520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_10520	COG0649	NAD binding
HN018_10525	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_10530	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_10560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HN018_10565	COG0564	pseudouridine synthase activity
HN018_10575	COG1254	Belongs to the acylphosphatase family
HN018_10590	COG0596	Alpha beta hydrolase
HN018_10595	COG0583	DNA-binding transcription factor activity
HN018_10600	COG0584	glycerophosphoryl diester phosphodiesterase
HN018_10615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HN018_10615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HN018_10640	COG2204	response regulator
HN018_10645	COG1923	regulation of RNA biosynthetic process
HN018_10650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HN018_10655	COG3956	TIGRFAM MazG family protein
HN018_10660	COG2801	Transposase and inactivated derivatives
HN018_10670	COG2719	SpoVR family
HN018_10675	COG2718	Belongs to the UPF0229 family
HN018_10680	COG2766	serine protein kinase
HN018_10685	COG0321	lipoyl(octanoyl) transferase activity
HN018_10685	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HN018_10690	COG0084	hydrolase, TatD family'
HN018_10705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HN018_10710	COG1686	Belongs to the peptidase S11 family
HN018_10720	COG2951	lytic endotransglycosylase activity
HN018_10750	COG1968	undecaprenyl-diphosphatase activity
HN018_10870	COG0305	Participates in initiation and elongation during chromosome replication
HN018_10905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HN018_10910	COG0154	amidase activity
HN018_10915	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HN018_10920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HN018_10945	COG0326	Molecular chaperone. Has ATPase activity
HN018_10980	COG0513	Belongs to the DEAD box helicase family
HN018_10995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HN018_11005	COG0531	amino acid
HN018_11010	COG0113	porphobilinogen synthase activity
HN018_11015	COG2366	antibiotic biosynthetic process
HN018_11020	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HN018_11025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HN018_11030	COG2271	Major facilitator Superfamily
HN018_11035	COG2084	Dehydrogenase
HN018_11040	COG0174	glutamine synthetase
HN018_11050	COG1381	Involved in DNA repair and RecF pathway recombination
HN018_11055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HN018_11060	COG0052	Belongs to the universal ribosomal protein uS2 family
HN018_11070	COG0300	oxidoreductase activity
HN018_11085	COG1136	(ABC) transporter
HN018_11095	COG0442	prolyl-tRNA aminoacylation
HN018_11105	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HN018_11115	COG1007	ATP synthesis coupled electron transport
HN018_11125	COG0713	ATP synthesis coupled electron transport
HN018_11135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_11140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HN018_11145	COG1034	ATP synthesis coupled electron transport
HN018_11160	COG0649	NAD binding
HN018_11165	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_11170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_11175	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_11200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HN018_11205	COG0740	serine-type endopeptidase activity
HN018_11210	COG0544	peptidyl-prolyl cis-trans isomerase activity
HN018_11220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HN018_11220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HN018_11230	COG3387	PFAM Glycoside hydrolase 15-related
HN018_11235	COG0513	Belongs to the DEAD box helicase family
HN018_11245	COG3214	Protein conserved in bacteria
HN018_11255	COG2151	metal-sulfur cluster biosynthetic enzyme
HN018_11265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HN018_11270	COG0719	Fe-S assembly protein
HN018_11275	COG0396	ATPase activity
HN018_11280	COG0719	Fe-S assembly protein
HN018_11290	COG2733	membrane
HN018_11300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN018_11310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HN018_11315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HN018_11325	COG5265	(ABC) transporter
HN018_11340	COG1486	melibiose metabolic process
HN018_11355	COG0395	ABC-type sugar transport system, permease component
HN018_11360	COG1794	racemase activity, acting on amino acids and derivatives
HN018_11365	COG4771	TonB-dependent receptor
HN018_11370	COG2814	Major facilitator Superfamily
HN018_11405	COG0628	permease
HN018_11420	COG0776	regulation of translation
HN018_11425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN018_11430	COG0416	fatty acid biosynthetic process
HN018_11435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HN018_11450	COG2205	protein histidine kinase activity
HN018_11455	COG0745	RESPONSE REGULATOR receiver
HN018_11460	COG1846	Transcriptional regulator
HN018_11475	COG0242	peptide deformylase activity
HN018_11480	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HN018_11490	COG0473	3-isopropylmalate dehydrogenase activity
HN018_11495	COG0066	3-isopropylmalate dehydratase activity
HN018_11500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HN018_11505	COG0335	large ribosomal subunit rRNA binding
HN018_11510	COG0336	Belongs to the RNA methyltransferase TrmD family
HN018_11515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HN018_11520	COG0228	four-way junction DNA binding
HN018_11530	COG3158	transport of potassium into the cell
HN018_11540	COG1160	GTP binding
HN018_11575	COG2814	Major facilitator Superfamily
HN018_11585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HN018_11590	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_11595	COG2814	Major facilitator Superfamily
HN018_11605	COG3180	Ammonia monooxygenase
HN018_11610	COG1335	isochorismatase
HN018_11615	COG1309	transcriptional regulator
HN018_11625	COG0438	transferase activity, transferring glycosyl groups
HN018_11640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HN018_11645	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN018_11665	COG1309	transcriptional regulator
HN018_11720	COG0679	Auxin Efflux Carrier
HN018_11730	COG0840	transmembrane signaling receptor activity
HN018_11735	COG0025	NhaP-type Na H and K H
HN018_11755	COG2022	thiamine diphosphate biosynthetic process
HN018_11775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HN018_11780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HN018_11785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HN018_11795	COG3300	MHYT domain
HN018_11795	COG5001	Diguanylate cyclase
HN018_11800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HN018_11840	COG0577	efflux transmembrane transporter activity
HN018_11840	COG1136	(ABC) transporter
HN018_11915	COG3501	Rhs element vgr protein
HN018_11920	COG0515	serine threonine protein kinase
HN018_11935	COG0500	methyltransferase
HN018_11995	COG0670	Belongs to the BI1 family
HN018_12000	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HN018_12010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HN018_12015	COG1573	uracil-dna glycosylase
HN018_12025	COG0601	transmembrane transport
HN018_12060	COG1309	transcriptional regulator
HN018_12075	COG2080	2 iron, 2 sulfur cluster binding
HN018_12075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HN018_12080	COG3224	Antibiotic biosynthesis monooxygenase
HN018_12085	COG0402	S-adenosylhomocysteine deaminase activity
HN018_12100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HN018_12110	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_12140	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HN018_12145	COG1199	ATP-dependent helicase activity
HN018_12150	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HN018_12155	COG1278	Cold shock
HN018_12160	COG0459	protein refolding
HN018_12165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HN018_12170	COG5425	PFAM Usg family protein
HN018_12195	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HN018_12200	COG2857	Cytochrome c1
HN018_12200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HN018_12230	COG2382	esterase
HN018_12260	COG3046	protein related to deoxyribodipyrimidine photolyase
HN018_12280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HN018_12285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN018_12295	COG3655	Transcriptional regulator
HN018_12325	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HN018_12335	COG0181	hydroxymethylbilane synthase activity
HN018_12340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HN018_12345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HN018_12350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HN018_12390	COG0493	'glutamate synthase
HN018_12395	COG0546	phosphoglycolate phosphatase activity
HN018_12405	COG5001	Diguanylate cyclase
HN018_12405	COG3300	MHYT domain
HN018_12420	COG2826	transposase and inactivated derivatives, IS30 family
HN018_12435	COG3162	membrane
HN018_12440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HN018_12450	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_12455	COG1129	ABC transporter
HN018_12460	COG1609	Transcriptional regulator
HN018_12465	COG3300	MHYT domain
HN018_12465	COG5001	Diguanylate cyclase
HN018_12470	COG2130	NADP-dependent
HN018_12475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HN018_12480	COG1309	transcriptional regulator
HN018_12500	COG2706	6-phosphogluconolactonase activity
HN018_12510	COG1845	cytochrome c oxidase, subunit III
HN018_12515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HN018_12520	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HN018_12535	COG2814	Major facilitator Superfamily
HN018_12545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HN018_12560	COG0784	Response regulator, receiver
HN018_12560	COG4191	Histidine kinase
HN018_12565	COG1506	peptidase
HN018_12565	COG0823	Involved in the tonB-independent uptake of proteins
HN018_12565	COG4946	Tricorn protease homolog
HN018_12585	COG0386	Belongs to the glutathione peroxidase family
HN018_12605	COG0076	glutamate decarboxylase activity
HN018_12610	COG0596	Alpha beta hydrolase
HN018_12620	COG1505	serine-type exopeptidase activity
HN018_12625	COG0671	phosphoesterase, PA-phosphatase related
HN018_12645	COG0673	inositol 2-dehydrogenase activity
HN018_12655	COG0436	Aminotransferase
HN018_12675	COG2095	MarC family integral membrane protein
HN018_12680	COG4993	Dehydrogenase
HN018_12695	COG3710	Transcriptional regulator
HN018_12705	COG4251	negative regulation of phosphorylation
HN018_12705	COG3706	GGDEF domain
HN018_12705	COG2203	Gaf domain
HN018_12705	COG5001	Diguanylate cyclase
HN018_12715	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HN018_12720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HN018_12730	COG0564	pseudouridine synthase activity
HN018_12755	COG0628	permease
HN018_12760	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_12760	COG3321	synthase
HN018_12760	COG0604	alcohol dehydrogenase
HN018_12765	COG0156	8-amino-7-oxononanoate synthase activity
HN018_12770	COG0300	oxidoreductase activity
HN018_12780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HN018_12785	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HN018_12805	COG0175	sulfate reduction
HN018_12820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN018_12825	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HN018_12830	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HN018_12860	COG0484	heat shock protein binding
HN018_12865	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HN018_12865	COG0506	proline dehydrogenase activity
HN018_12865	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HN018_12880	COG1201	RNA secondary structure unwinding
HN018_12890	COG0415	Belongs to the DNA photolyase family
HN018_12895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HN018_12900	COG1605	Chorismate mutase
HN018_12900	COG0287	Prephenate dehydrogenase
HN018_12925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HN018_12930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HN018_12950	COG2226	methyltransferase
HN018_12970	COG0142	geranyltranstransferase activity
HN018_12990	COG5002	protein histidine kinase activity
HN018_12990	COG5001	Diguanylate cyclase
HN018_13005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HN018_13015	COG0842	Transport permease protein
HN018_13020	COG1131	(ABC) transporter
HN018_13025	COG0129	dihydroxy-acid dehydratase activity
HN018_13035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN018_13060	COG5001	Diguanylate cyclase
HN018_13075	COG1309	transcriptional regulator
HN018_13170	COG2826	transposase and inactivated derivatives, IS30 family
HN018_13210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HN018_13215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HN018_13220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HN018_13260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HN018_13265	COG1960	acyl-CoA dehydrogenase activity
HN018_13285	COG1522	sequence-specific DNA binding
HN018_13300	COG2814	Major facilitator Superfamily
HN018_13315	COG4771	TonB-dependent receptor
HN018_13325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HN018_13335	COG4948	Mandelate Racemase Muconate Lactonizing
HN018_13340	COG3104	oligopeptide transport
HN018_13360	COG2271	Major facilitator Superfamily
HN018_13365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN018_13375	COG2186	Transcriptional regulator
HN018_13385	COG2271	Major facilitator Superfamily
HN018_13395	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HN018_13410	COG3750	Belongs to the UPF0335 family
HN018_13415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HN018_13435	COG3875	lactate racemase activity
HN018_13445	COG0667	Aldo Keto reductase
HN018_13450	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_13470	COG2084	Dehydrogenase
HN018_13480	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HN018_13485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HN018_13490	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HN018_13495	COG0215	cysteine-tRNA ligase activity
HN018_13505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HN018_13520	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HN018_13525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HN018_13540	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HN018_13555	COG1937	Protein conserved in bacteria
HN018_13565	COG1596	polysaccharide export
HN018_13600	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HN018_13615	COG1215	transferase activity, transferring glycosyl groups
HN018_13620	COG0438	transferase activity, transferring glycosyl groups
HN018_13640	COG0659	secondary active sulfate transmembrane transporter activity
HN018_13645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HN018_13650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HN018_13660	COG3008	intermembrane lipid transfer
HN018_13660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HN018_13690	COG0459	protein refolding
HN018_13730	COG0583	DNA-binding transcription factor activity
HN018_13735	COG2814	Major facilitator Superfamily
HN018_13745	COG0667	Aldo Keto reductase
HN018_13750	COG1349	DNA-binding transcription factor activity
HN018_13760	COG1129	ABC transporter
HN018_13765	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_13770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN018_13775	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
HN018_13805	COG3395	kinase activity
HN018_13810	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HN018_13825	COG1959	2 iron, 2 sulfur cluster binding
HN018_13835	COG2070	2-Nitropropane dioxygenase
HN018_13845	COG2096	Adenosyltransferase
HN018_13870	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HN018_13890	COG0583	DNA-binding transcription factor activity
HN018_13895	COG1902	pentaerythritol trinitrate reductase activity
HN018_13930	COG3547	Transposase (IS116 IS110 IS902 family)
HN018_13940	COG2814	Major facilitator Superfamily
HN018_13945	COG1309	transcriptional regulator
HN018_13950	COG3118	belongs to the thioredoxin family
HN018_13965	COG0625	glutathione transferase activity
HN018_13995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HN018_13995	COG2080	2 iron, 2 sulfur cluster binding
HN018_14010	COG0723	plastoquinol--plastocyanin reductase activity
HN018_14020	COG2001	Belongs to the MraZ family
HN018_14025	COG0275	rRNA processing
HN018_14040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HN018_14045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HN018_14050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HN018_14055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HN018_14065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HN018_14070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HN018_14075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HN018_14080	COG1181	Belongs to the D-alanine--D-alanine ligase family
HN018_14085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HN018_14090	COG0849	cell division
HN018_14120	COG0559	Belongs to the binding-protein-dependent transport system permease family
HN018_14140	COG0402	S-adenosylhomocysteine deaminase activity
HN018_14150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HN018_14155	COG0497	DNA recombination
HN018_14160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HN018_14175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HN018_14180	COG0237	dephospho-CoA kinase activity
HN018_14185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HN018_14205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN018_14210	COG0165	Argininosuccinate lyase
HN018_14245	COG0019	diaminopimelate decarboxylase activity
HN018_14260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN018_14265	COG0477	Major facilitator Superfamily
HN018_14290	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_14300	COG1902	pentaerythritol trinitrate reductase activity
HN018_14320	COG0248	Ppx GppA phosphatase
HN018_14325	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HN018_14350	COG0405	Gamma-glutamyltransferase
HN018_14355	COG0784	Response regulator, receiver
HN018_14355	COG4191	Histidine kinase
HN018_14360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HN018_14365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HN018_14370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HN018_14390	COG0105	UTP biosynthetic process
HN018_14395	COG0488	(ABC) transporter
HN018_14400	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_14410	COG3537	Alpha-1,2-mannosidase
HN018_14420	COG1957	nucleoside hydrolase
HN018_14435	COG0251	oxidation-reduction process
HN018_14445	COG0175	sulfate reduction
HN018_14460	COG0662	Cupin 2, conserved barrel domain protein
HN018_14460	COG2207	Transcriptional regulator
HN018_14470	COG4221	oxidoreductase activity
HN018_14495	COG1086	Polysaccharide biosynthesis protein
HN018_14500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HN018_14515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HN018_14560	COG2115	Belongs to the xylose isomerase family
HN018_14565	COG1609	Transcriptional regulator
HN018_14575	COG4213	ABC transporter substrate-binding protein
HN018_14585	COG4214	carbohydrate transport
HN018_14590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HN018_14610	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HN018_14625	COG0745	RESPONSE REGULATOR receiver
HN018_14650	COG4786	Flagellar basal body rod
HN018_14655	COG4786	Flagellar basal body rod
HN018_14665	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HN018_14680	COG1706	bacterial-type flagellum-dependent cell motility
HN018_14700	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HN018_14740	COG2205	protein histidine kinase activity
HN018_14745	COG2271	Major facilitator Superfamily
HN018_14750	COG1238	metal cluster binding
HN018_14760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HN018_14775	COG0741	lytic transglycosylase activity
HN018_14790	COG1253	flavin adenine dinucleotide binding
HN018_14800	COG2372	response to copper ion
HN018_14810	COG0019	diaminopimelate decarboxylase activity
HN018_14815	COG1295	ribonuclease BN
HN018_14820	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HN018_14825	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HN018_14835	COG0439	Biotin carboxylase
HN018_14845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HN018_14855	COG0398	Pfam SNARE associated Golgi protein
HN018_14860	COG1612	heme a metabolic process
HN018_14865	COG0312	modulator of DNA gyrase
HN018_14870	COG2814	Major facilitator Superfamily
HN018_14880	COG0667	Aldo Keto reductase
HN018_14900	COG1127	ABC transporter
HN018_14905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HN018_14915	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HN018_14945	COG0305	Participates in initiation and elongation during chromosome replication
HN018_14955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HN018_14955	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HN018_14960	COG0194	GDP metabolic process
HN018_14975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HN018_15000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HN018_15025	COG0436	Aminotransferase
HN018_15030	COG0405	Gamma-glutamyltransferase
HN018_15050	COG2271	Major facilitator Superfamily
HN018_15055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN018_15060	COG0156	8-amino-7-oxononanoate synthase activity
HN018_15070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HN018_15080	COG0126	phosphoglycerate kinase activity
HN018_15115	COG0519	Catalyzes the synthesis of GMP from XMP
HN018_15120	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_15130	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_15140	COG1312	Catalyzes the dehydration of D-mannonate
HN018_15145	COG4106	trans-aconitate 2-methyltransferase activity
HN018_15150	COG0552	protein localization to endoplasmic reticulum
HN018_15155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HN018_15160	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HN018_15165	COG0277	FAD linked oxidase domain protein
HN018_15175	COG0154	amidase activity
HN018_15215	COG2116	formate transmembrane transporter activity
HN018_15230	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HN018_15235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HN018_15245	COG0667	Aldo Keto reductase
HN018_15260	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HN018_15265	COG0745	RESPONSE REGULATOR receiver
HN018_15270	COG0583	DNA-binding transcription factor activity
HN018_15280	COG0655	NAD(P)H dehydrogenase (quinone) activity
HN018_15320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN018_15330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HN018_15365	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_15390	COG0471	metal ion transport
HN018_15390	COG0490	domain, Protein
HN018_15405	COG2204	response regulator
HN018_15410	COG2205	protein histidine kinase activity
HN018_15420	COG0412	Dienelactone hydrolase
HN018_15430	COG3588	fructose-bisphosphate aldolase
HN018_15455	COG0246	Mannitol dehydrogenase
HN018_15460	COG1879	ABC-type sugar transport system periplasmic component
HN018_15470	COG5441	Belongs to the UPF0261 family
HN018_15475	COG5564	TIM-barrel signal transduction protein
HN018_15495	COG0481	GTPase activity
HN018_15510	COG0072	phenylalanine-tRNA ligase activity
HN018_15510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN018_15515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HN018_15520	COG1129	ABC transporter
HN018_15535	COG1609	Transcriptional regulator
HN018_15540	COG0366	Alpha amylase catalytic
HN018_15545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HN018_15550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HN018_15570	COG0488	(ABC) transporter
HN018_15575	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HN018_15585	COG4208	sulfate ABC transporter
HN018_15590	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HN018_15600	COG5383	Protein conserved in bacteria
HN018_15605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HN018_15615	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_15655	COG2814	Major facilitator Superfamily
HN018_15660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HN018_15680	COG3511	phospholipase C
HN018_15685	COG1793	dna ligase
HN018_15725	COG0395	ABC-type sugar transport system, permease component
HN018_15730	COG1175	transmembrane transport
HN018_15740	COG1609	Transcriptional regulator
HN018_15750	COG0784	Response regulator, receiver
HN018_15750	COG4191	Histidine kinase
HN018_15765	COG0729	surface antigen
HN018_15775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HN018_15780	COG1702	phosphate starvation-inducible protein PhoH
HN018_15785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HN018_15795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HN018_15820	COG2943	transferase activity, transferring hexosyl groups
HN018_15825	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HN018_15840	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_15850	COG1063	alcohol dehydrogenase
HN018_15855	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_15865	COG1879	ABC-type sugar transport system periplasmic component
HN018_15875	COG0698	ribose 5-phosphate isomerase
HN018_15910	COG0489	protein tyrosine kinase activity
HN018_15920	COG3237	CsbD-like
HN018_15945	COG2261	transglycosylase associated protein
HN018_15950	COG0179	Fumarylacetoacetate (FAA) hydrolase
HN018_15960	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HN018_15990	COG0534	Mate efflux family protein
HN018_15995	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HN018_16000	COG0343	queuine tRNA-ribosyltransferase activity
HN018_16005	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HN018_16015	COG5002	protein histidine kinase activity
HN018_16015	COG5001	Diguanylate cyclase
HN018_16025	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HN018_16030	COG3023	N-Acetylmuramoyl-L-alanine amidase
HN018_16050	COG2853	Lipoprotein
HN018_16065	COG0488	(ABC) transporter
HN018_16075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HN018_16115	COG0646	methionine synthase
HN018_16115	COG1410	methionine synthase
HN018_16130	COG0140	phosphoribosyl-ATP diphosphatase activity
HN018_16140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HN018_16150	COG2226	methyltransferase
HN018_16165	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HN018_16175	COG2233	PERMEase
HN018_16195	COG0784	Response regulator, receiver
HN018_16195	COG2198	Histidine kinase
HN018_16195	COG2205	protein histidine kinase activity
HN018_16200	COG1024	Enoyl-CoA hydratase
HN018_16210	COG0523	cobalamin synthesis protein
HN018_16220	COG0438	transferase activity, transferring glycosyl groups
HN018_16225	COG0625	glutathione transferase activity
HN018_16230	COG0482	sulfurtransferase activity
HN018_16235	COG0633	Ferredoxin
HN018_16240	COG1104	cysteine desulfurase activity
HN018_16250	COG2945	thiolester hydrolase activity
HN018_16255	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HN018_16260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HN018_16265	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_16280	COG1959	2 iron, 2 sulfur cluster binding
HN018_16300	COG1064	alcohol dehydrogenase
HN018_16310	COG5001	Diguanylate cyclase
HN018_16315	COG0673	inositol 2-dehydrogenase activity
HN018_16345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HN018_16350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HN018_16355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN018_16365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HN018_16380	COG2226	methyltransferase
HN018_16395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HN018_16410	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HN018_16420	COG1914	H( )-stimulated, divalent metal cation uptake system
HN018_16425	COG1321	iron dependent repressor
HN018_16430	COG4566	intracellular signal transduction
HN018_16435	COG0563	adenylate kinase activity
HN018_16440	COG4251	negative regulation of phosphorylation
HN018_16445	COG3590	peptidase
HN018_16455	COG0045	succinate-CoA ligase (ADP-forming) activity
HN018_16460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HN018_16480	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HN018_16485	COG0799	negative regulation of ribosome biogenesis
HN018_16490	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HN018_16495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HN018_16500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN018_16515	COG2755	lipolytic protein G-D-S-L family
HN018_16515	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HN018_16520	COG0012	GTP binding
HN018_16525	COG0193	aminoacyl-tRNA hydrolase activity
HN018_16530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HN018_16535	COG3177	Filamentation induced by cAMP protein fic
HN018_16540	COG0406	alpha-ribazole phosphatase activity
HN018_16545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HN018_16565	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HN018_16600	COG0776	regulation of translation
HN018_16605	COG3754	Rhamnan synthesis protein F
HN018_16620	COG1216	Glycosyl transferase, family 2
HN018_16620	COG0438	transferase activity, transferring glycosyl groups
HN018_16625	COG1088	dTDP-glucose 4,6-dehydratase activity
HN018_16630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HN018_16635	COG0679	Auxin Efflux Carrier
HN018_16645	COG3052	prosthetic group binding
HN018_16665	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HN018_16675	COG0251	oxidation-reduction process
HN018_16680	COG0668	transmembrane transport
HN018_16705	COG0531	amino acid
HN018_16710	COG1770	oligopeptidase
HN018_16720	COG4774	siderophore transport
HN018_16755	COG1215	transferase activity, transferring glycosyl groups
HN018_16770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN018_16775	COG1032	radical SAM domain protein
HN018_16805	COG5487	UPF0391 membrane protein
HN018_16810	COG0840	transmembrane signaling receptor activity
HN018_16815	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HN018_16820	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HN018_16825	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HN018_16830	COG1877	trehalose-phosphatase activity
HN018_16855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HN018_16870	COG0538	isocitrate dehydrogenase activity
HN018_16880	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HN018_16885	COG1684	flagellar biosynthetic protein fliR
HN018_16890	COG1987	bacterial-type flagellum assembly
HN018_16895	COG1677	Flagellar hook-basal body complex protein FliE
HN018_16900	COG1558	bacterial-type flagellum-dependent cell motility
HN018_16915	COG1338	Plays a role in the flagellum-specific transport system
HN018_16930	COG1982	Orn Lys Arg decarboxylase major
HN018_16935	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HN018_16945	COG0114	fumarate hydratase activity
HN018_16965	COG0784	Response regulator, receiver
HN018_16965	COG4191	Histidine kinase
HN018_16980	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_16985	COG4948	Mandelate Racemase Muconate Lactonizing
HN018_16995	COG1063	alcohol dehydrogenase
HN018_17000	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_17005	COG1129	ABC transporter
HN018_17010	COG1879	ABC-type sugar transport system periplasmic component
HN018_17015	COG2186	Transcriptional regulator
HN018_17020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_17035	COG0778	Nitroreductase
HN018_17045	COG0386	Belongs to the glutathione peroxidase family
HN018_17055	COG0131	Imidazoleglycerol-phosphate dehydratase
HN018_17060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HN018_17065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HN018_17070	COG0107	imidazoleglycerol-phosphate synthase activity
HN018_17075	COG0140	phosphoribosyl-ATP diphosphatase activity
HN018_17090	COG1902	pentaerythritol trinitrate reductase activity
HN018_17095	COG3300	MHYT domain
HN018_17095	COG5001	Diguanylate cyclase
HN018_17120	COG5265	(ABC) transporter
HN018_17135	COG0658	competence protein
HN018_17135	COG2333	competence protein COMEC
HN018_17140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HN018_17145	COG0540	Belongs to the ATCase OTCase family
HN018_17155	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HN018_17160	COG0758	DNA mediated transformation
HN018_17165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HN018_17170	COG0557	exoribonuclease II activity
HN018_17175	COG0793	Belongs to the peptidase S41A family
HN018_17195	COG0457	Tetratricopeptide repeat
HN018_17200	COG4206	TonB-dependent receptor
HN018_17205	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HN018_17205	COG2885	chlorophyll binding
HN018_17215	COG1959	2 iron, 2 sulfur cluster binding
HN018_17220	COG0450	alkyl hydroperoxide reductase
HN018_17225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HN018_17240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN018_17245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HN018_17250	COG0187	DNA topoisomerase II activity
HN018_17260	COG2124	cytochrome p450
HN018_17280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HN018_17290	COG0656	L-ascorbic acid biosynthetic process
HN018_17295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HN018_17300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HN018_17310	COG0196	riboflavin kinase activity
HN018_17315	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HN018_17320	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HN018_17325	COG0235	Class ii aldolase
HN018_17330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HN018_17345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HN018_17350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HN018_17375	COG4232	protein-disulfide reductase activity
HN018_17380	COG1643	Atp-dependent helicase
HN018_17390	COG0745	RESPONSE REGULATOR receiver
HN018_17395	COG2205	protein histidine kinase activity
HN018_17415	COG0463	Glycosyl transferase, family 2
HN018_17425	COG0772	Belongs to the SEDS family
HN018_17435	COG0028	Belongs to the TPP enzyme family
HN018_17445	COG3768	UPF0283 membrane protein
HN018_17450	COG3106	COG3106 Predicted ATPase
HN018_17460	COG1472	Belongs to the glycosyl hydrolase 3 family
HN018_17465	COG0768	penicillin binding
HN018_17500	COG0151	Belongs to the GarS family
HN018_17505	COG1570	exodeoxyribonuclease VII activity
HN018_17540	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HN018_17545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HN018_17570	COG0513	Belongs to the DEAD box helicase family
HN018_17585	COG1940	carbohydrate kinase activity
HN018_17595	COG1722	exodeoxyribonuclease VII activity
HN018_17600	COG0142	geranyltranstransferase activity
HN018_17605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HN018_17610	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HN018_17620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HN018_17630	COG0246	Mannitol dehydrogenase
HN018_17635	COG1070	Carbohydrate kinase
HN018_17660	COG2226	methyltransferase
HN018_17670	COG0137	argininosuccinate synthase activity
HN018_17685	COG1435	thymidine kinase activity
HN018_17690	COG0180	Tryptophanyl-tRNA synthetase
HN018_17695	COG0432	Pfam Uncharacterised protein family UPF0047
HN018_17720	COG0395	ABC-type sugar transport system, permease component
HN018_17735	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HN018_17740	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HN018_17745	COG0243	molybdopterin cofactor binding
HN018_17760	COG0778	Nitroreductase
HN018_17765	COG1301	dicarboxylic acid transport
HN018_17775	COG1129	ABC transporter
HN018_17780	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_17785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HN018_17790	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HN018_17795	COG2080	2 iron, 2 sulfur cluster binding
HN018_17800	COG0681	Belongs to the peptidase S26 family
HN018_17820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HN018_17825	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HN018_17835	COG1595	DNA-templated transcription, initiation
HN018_17855	COG1129	ABC transporter
HN018_17875	COG3781	membrane
HN018_17885	COG2824	Alkylphosphonate utilization operon protein PhnA
HN018_17890	COG3706	GGDEF domain
HN018_17900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN018_17905	COG0745	RESPONSE REGULATOR receiver
HN018_17910	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_17920	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_17925	COG1129	ABC transporter
HN018_17935	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_17940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HN018_17945	COG3958	Transketolase
HN018_17950	COG3959	Transketolase, thiamine diphosphate binding domain
HN018_17955	COG4251	negative regulation of phosphorylation
HN018_17975	COG4181	ATPase activity
HN018_17990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HN018_17995	COG1116	anion transmembrane transporter activity
HN018_18000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HN018_18005	COG0840	transmembrane signaling receptor activity
HN018_18020	COG1132	(ABC) transporter
HN018_18025	COG0793	Belongs to the peptidase S41A family
HN018_18025	COG4946	Tricorn protease homolog
HN018_18040	COG2186	Transcriptional regulator
HN018_18045	COG1879	ABC-type sugar transport system periplasmic component
HN018_18050	COG1129	ABC transporter
HN018_18055	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_18060	COG3386	PFAM SMP-30 Gluconolaconase
HN018_18065	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_18070	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_18075	COG1129	ABC transporter
HN018_18080	COG1879	ABC-type sugar transport system periplasmic component
HN018_18090	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HN018_18095	COG1454	alcohol dehydrogenase
HN018_18105	COG1129	ABC transporter
HN018_18110	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_18130	COG1070	Carbohydrate kinase
HN018_18150	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_18160	COG3254	rhamnose metabolic process
HN018_18165	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_18170	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_18185	COG1349	DNA-binding transcription factor activity
HN018_18190	COG3347	Dehydrogenase
HN018_18190	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_18195	COG4952	isomerase
HN018_18200	COG0247	lactate metabolic process
HN018_18205	COG1139	Iron-sulfur cluster binding protein
HN018_18220	COG3275	phosphorelay sensor kinase activity
HN018_18225	COG3279	Response regulator of the LytR AlgR family
HN018_18330	COG3206	protein involved in exopolysaccharide biosynthesis
HN018_18330	COG0489	protein tyrosine kinase activity
HN018_18340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HN018_18345	COG1238	metal cluster binding
HN018_18350	COG2197	response regulator
HN018_18355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HN018_18395	COG2094	Belongs to the DNA glycosylase MPG family
HN018_18410	COG3550	peptidyl-serine autophosphorylation
HN018_18420	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_18440	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HN018_18445	COG2835	tetraacyldisaccharide 4'-kinase activity
HN018_18450	COG3153	acetyltransferase
HN018_18455	COG3842	ATPase activity
HN018_18465	COG1175	transmembrane transport
HN018_18475	COG1063	alcohol dehydrogenase
HN018_18480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HN018_18490	COG0028	Belongs to the TPP enzyme family
HN018_18495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HN018_18500	COG3830	Belongs to the UPF0237 family
HN018_18500	COG0560	Phosphoserine phosphatase
HN018_18510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HN018_18535	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_18540	COG0179	Fumarylacetoacetate (FAA) hydrolase
HN018_18545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HN018_18565	COG0702	epimerase
HN018_18590	COG0318	PFAM AMP-dependent synthetase and ligase
HN018_18600	COG0456	acetyltransferase
HN018_18630	COG1597	lipid kinase activity
HN018_18640	COG0156	8-amino-7-oxononanoate synthase activity
HN018_18665	COG3239	Fatty acid desaturase
HN018_18675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HN018_18675	COG0519	Catalyzes the synthesis of GMP from XMP
HN018_18710	COG1216	Glycosyl transferase, family 2
HN018_18710	COG0438	transferase activity, transferring glycosyl groups
HN018_18730	COG1956	GAF domain-containing protein
HN018_18745	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HN018_18750	COG1360	Flagellar Motor Protein
HN018_18765	COG1522	sequence-specific DNA binding
HN018_18770	COG0492	ferredoxin-NADP+ reductase activity
HN018_18775	COG0583	DNA-binding transcription factor activity
HN018_18795	COG0776	regulation of translation
HN018_18800	COG0616	signal peptide processing
HN018_18825	COG0494	nUDIX hydrolase
HN018_18840	COG1073	alpha beta
HN018_18845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN018_18860	COG0028	Belongs to the TPP enzyme family
HN018_18865	COG0582	viral genome integration into host DNA
HN018_18900	COG0596	Alpha beta hydrolase
HN018_18900	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN018_18910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HN018_18910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HN018_18915	COG1999	signal sequence binding
HN018_18920	COG0747	negative chemotaxis
HN018_18930	COG0601	transmembrane transport
HN018_18940	COG4608	Belongs to the ABC transporter superfamily
HN018_18945	COG1671	Belongs to the UPF0178 family
HN018_18955	COG3265	gluconokinase activity
HN018_18965	COG0363	glucosamine-6-phosphate deaminase activity
HN018_18975	COG0561	phosphatase activity
HN018_18980	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HN018_18985	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HN018_18990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HN018_19025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HN018_19040	COG0583	DNA-binding transcription factor activity
HN018_19050	COG1063	alcohol dehydrogenase
HN018_19060	COG2351	hydroxyisourate hydrolase activity
HN018_19065	COG2072	flavoprotein involved in K transport
HN018_19080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HN018_19095	COG3038	cytochrome b561
HN018_19100	COG3585	molybdate ion transport
HN018_19125	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HN018_19130	COG4149	molybdate abc transporter
HN018_19135	COG0725	ABC transporter, periplasmic molybdate-binding protein
HN018_19140	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HN018_19155	COG0668	transmembrane transport
HN018_19165	COG1696	Membrane protein involved in D-alanine export
HN018_19205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HN018_19255	COG0741	lytic transglycosylase activity
HN018_19255	COG0739	heme binding
HN018_19255	COG1196	nuclear chromosome segregation
HN018_19265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN018_19265	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HN018_19350	COG2826	transposase and inactivated derivatives, IS30 family
HN018_19410	COG2826	transposase and inactivated derivatives, IS30 family
HN018_19440	COG1484	DNA-dependent DNA replication
HN018_19445	COG4584	PFAM Integrase catalytic
HN018_19465	COG3920	Histidine kinase
HN018_19470	COG0784	Response regulator, receiver
HN018_19470	COG4191	Histidine kinase
HN018_19480	COG4372	Transposase
HN018_19485	COG4372	Transposase
HN018_19490	COG3436	PFAM IS66 Orf2 family protein
HN018_19505	COG3436	PFAM IS66 Orf2 family protein
HN018_19530	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HN018_19620	COG1902	pentaerythritol trinitrate reductase activity
HN018_19625	COG0583	DNA-binding transcription factor activity
HN018_19650	COG2967	ApaG domain
HN018_19660	COG0302	gtp cyclohydrolase
HN018_19670	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HN018_19695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HN018_19700	COG0521	Mo-molybdopterin cofactor biosynthetic process
HN018_19705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HN018_19705	COG1648	precorrin-2 dehydrogenase activity
HN018_19720	COG2755	lipolytic protein G-D-S-L family
HN018_19720	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HN018_19730	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HN018_19730	COG2755	lipolytic protein G-D-S-L family
HN018_19745	COG2124	cytochrome p450
HN018_19750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HN018_19810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HN018_19815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HN018_19855	COG3275	phosphorelay sensor kinase activity
HN018_19860	COG0596	Alpha beta hydrolase
HN018_19875	COG2986	histidine ammonia-lyase
HN018_19880	COG2423	ornithine cyclodeaminase activity
HN018_19885	COG2271	Major facilitator Superfamily
HN018_19900	COG0402	S-adenosylhomocysteine deaminase activity
HN018_19905	COG0513	Belongs to the DEAD box helicase family
HN018_19925	COG0745	RESPONSE REGULATOR receiver
HN018_19935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HN018_19940	COG0581	inorganic phosphate transmembrane transporter activity
HN018_19950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HN018_19965	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_19970	COG1129	ABC transporter
HN018_20005	COG1737	Transcriptional regulator
HN018_20010	COG0673	inositol 2-dehydrogenase activity
HN018_20025	COG3300	MHYT domain
HN018_20025	COG5001	Diguanylate cyclase
HN018_20030	COG0328	RNA-DNA hybrid ribonuclease activity
HN018_20035	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HN018_20040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HN018_20050	COG0509	glycine decarboxylation via glycine cleavage system
HN018_20065	COG2814	Major facilitator Superfamily
HN018_20070	COG1297	OPT oligopeptide transporter protein
HN018_20075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HN018_20080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HN018_20090	COG1505	serine-type exopeptidase activity
HN018_20145	COG0438	transferase activity, transferring glycosyl groups
HN018_20160	COG2226	methyltransferase
HN018_20175	COG0463	Glycosyl transferase, family 2
HN018_20180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HN018_20185	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HN018_20190	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HN018_20195	COG0356	it plays a direct role in the translocation of protons across the membrane
HN018_20205	COG2837	iron assimilation
HN018_20220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HN018_20220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HN018_20225	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HN018_20230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HN018_20240	COG2814	Major facilitator Superfamily
HN018_20245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HN018_20250	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_20255	COG4970	Tfp pilus assembly protein FimT
HN018_20260	COG1216	Glycosyl transferase, family 2
HN018_20270	COG0612	Peptidase, M16
HN018_20275	COG2165	general secretion pathway protein
HN018_20285	COG3166	PFAM Fimbrial assembly family protein
HN018_20325	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_20345	COG1309	transcriptional regulator
HN018_20355	COG1012	belongs to the aldehyde dehydrogenase family
HN018_20360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN018_20370	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_20375	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_20380	COG1129	ABC transporter
HN018_20390	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HN018_20400	COG1879	ABC-type sugar transport system periplasmic component
HN018_20405	COG1063	alcohol dehydrogenase
HN018_20425	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_20445	COG2195	Cleaves the N-terminal amino acid of tripeptides
HN018_20455	COG3239	Fatty acid desaturase
HN018_20470	COG3718	enzyme involved in inositol metabolism
HN018_20475	COG3962	Belongs to the TPP enzyme family
HN018_20480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN018_20485	COG1459	type II secretion system
HN018_20490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HN018_20520	COG0438	transferase activity, transferring glycosyl groups
HN018_20540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HN018_20545	COG1464	Belongs to the NlpA lipoprotein family
HN018_20550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HN018_20555	COG2011	ABC-type metal ion transport system permease component
HN018_20570	COG0776	regulation of translation
HN018_20575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HN018_20580	COG2309	aminopeptidase activity
HN018_20585	COG0438	transferase activity, transferring glycosyl groups
HN018_20600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HN018_20600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HN018_20615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HN018_20620	COG3158	transport of potassium into the cell
HN018_20625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HN018_20645	COG0741	lytic transglycosylase activity
HN018_20655	COG1902	pentaerythritol trinitrate reductase activity
HN018_20670	COG0495	leucyl-tRNA aminoacylation
HN018_20695	COG3387	PFAM Glycoside hydrolase 15-related
HN018_20705	COG0437	4 iron, 4 sulfur cluster binding
HN018_20730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HN018_20735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HN018_20760	COG3045	CreA protein
HN018_20790	COG0281	malic enzyme
HN018_20790	COG0280	phosphate acetyltransferase
HN018_20795	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HN018_20825	COG1842	Phage shock protein A
HN018_20830	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HN018_20835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN018_20840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN018_20870	COG2721	sulfolactate sulfo-lyase activity
HN018_20875	COG1879	ABC-type sugar transport system periplasmic component
HN018_20880	COG1129	ABC transporter
HN018_20885	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_20890	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_20895	COG4221	oxidoreductase activity
HN018_20900	COG3104	oligopeptide transport
HN018_20910	COG0564	pseudouridine synthase activity
HN018_20915	COG2223	nitrite transmembrane transporter activity
HN018_20935	COG1129	ABC transporter
HN018_20940	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_20945	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_20960	COG1070	Carbohydrate kinase
HN018_20965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HN018_20970	COG0022	dehydrogenase e1 component
HN018_20970	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN018_20975	COG0596	Alpha beta hydrolase
HN018_20975	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN018_20985	COG1129	ABC transporter
HN018_20990	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_20995	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_21000	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_21010	COG0742	ribosomal rna small subunit methyltransferase
HN018_21015	COG1187	pseudouridine synthase activity
HN018_21020	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HN018_21025	COG0590	tRNA wobble adenosine to inosine editing
HN018_21025	COG0037	tRNA processing
HN018_21040	COG2814	Major facilitator Superfamily
HN018_21090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HN018_21095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HN018_21100	COG1116	anion transmembrane transporter activity
HN018_21105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HN018_21115	COG1215	transferase activity, transferring glycosyl groups
HN018_21120	COG1091	dTDP-4-dehydrorhamnose reductase activity
HN018_21155	COG0259	pyridoxamine-phosphate oxidase activity
HN018_21160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HN018_21165	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HN018_21170	COG2121	Domain of unknown function (DUF374)
HN018_21175	COG1519	Transferase
HN018_21180	COG1663	tetraacyldisaccharide 4'-kinase activity
HN018_21195	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HN018_21200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HN018_21205	COG3237	CsbD-like
HN018_21220	COG0138	bifunctional purine biosynthesis protein purh
HN018_21225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HN018_21230	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HN018_21230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HN018_21235	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HN018_21235	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HN018_21250	COG1216	Glycosyl transferase, family 2
HN018_21250	COG0438	transferase activity, transferring glycosyl groups
HN018_21260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HN018_21265	COG1121	(ABC) transporter
HN018_21275	COG0735	belongs to the Fur family
HN018_21290	COG0285	dihydrofolate synthase activity
HN018_21295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HN018_21300	COG0159	tryptophan synthase activity
HN018_21305	COG0133	tryptophan synthase activity
HN018_21310	COG0598	Magnesium transport protein CorA
HN018_21320	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HN018_21330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HN018_21335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HN018_21340	COG0445	tRNA wobble uridine modification
HN018_21345	COG0357	Ribosomal RNA small subunit methyltransferase G
HN018_21370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HN018_21375	COG0424	maF-like protein
HN018_21390	COG0586	Pfam SNARE associated Golgi protein
HN018_21395	COG0590	tRNA wobble adenosine to inosine editing
HN018_21420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HN018_21430	COG1566	PFAM secretion protein HlyD family protein
HN018_21440	COG1289	transmembrane transporter activity
HN018_21455	COG2826	transposase and inactivated derivatives, IS30 family
HN018_21480	COG0024	Methionine aminopeptidase
HN018_21515	COG0583	DNA-binding transcription factor activity
HN018_21525	COG0300	oxidoreductase activity
HN018_21540	COG1484	DNA-dependent DNA replication
HN018_21560	COG0587	DNA-directed DNA polymerase activity
HN018_21585	COG0287	Prephenate dehydrogenase
HN018_21595	COG1850	ribulose-bisphosphate carboxylase activity
HN018_21605	COG0149	triose-phosphate isomerase activity
HN018_21620	COG1879	ABC-type sugar transport system periplasmic component
HN018_21630	COG1129	ABC transporter
HN018_21635	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_21640	COG0673	inositol 2-dehydrogenase activity
HN018_21650	COG2186	Transcriptional regulator
HN018_21655	COG0667	Aldo Keto reductase
HN018_21665	COG1116	anion transmembrane transporter activity
HN018_21700	COG1960	acyl-CoA dehydrogenase activity
HN018_21705	COG1024	Enoyl-CoA hydratase
HN018_21705	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN018_21710	COG0183	Belongs to the thiolase family
HN018_21720	COG0318	PFAM AMP-dependent synthetase and ligase
HN018_21725	COG0789	Transcriptional regulator
HN018_21730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HN018_21760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN018_21775	COG2223	nitrite transmembrane transporter activity
HN018_21780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HN018_21790	COG1024	Enoyl-CoA hydratase
HN018_21820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HN018_21825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HN018_21830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HN018_21840	COG0243	molybdopterin cofactor binding
HN018_21855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HN018_21890	COG4372	Transposase
HN018_21900	COG4372	Transposase
HN018_21920	COG0753	catalase activity
HN018_21935	COG5001	Diguanylate cyclase
HN018_21950	COG0784	Response regulator, receiver
HN018_21950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HN018_21950	COG2198	Histidine kinase
HN018_21950	COG2205	protein histidine kinase activity
HN018_21975	COG4372	Transposase
HN018_21980	COG3436	PFAM IS66 Orf2 family protein
HN018_21985	COG2963	transposase activity
HN018_22005	COG2433	Pfam Transposase IS66
HN018_22010	COG3436	PFAM IS66 Orf2 family protein
HN018_22015	COG2963	transposase activity
HN018_22065	COG0745	RESPONSE REGULATOR receiver
HN018_22095	COG1484	DNA-dependent DNA replication
HN018_22100	COG4584	PFAM Integrase catalytic
HN018_22220	COG3547	Transposase (IS116 IS110 IS902 family)
HN018_22230	COG3547	Transposase (IS116 IS110 IS902 family)
HN018_22235	COG3387	PFAM Glycoside hydrolase 15-related
HN018_22240	COG1252	NADH dehydrogenase
HN018_22245	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HN018_22250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HN018_22290	COG1566	PFAM secretion protein HlyD family protein
HN018_22315	COG0789	Transcriptional regulator
HN018_22325	COG4372	Transposase
HN018_22330	COG3436	PFAM IS66 Orf2 family protein
HN018_22345	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HN018_22380	COG1902	pentaerythritol trinitrate reductase activity
HN018_22385	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_22395	COG0583	DNA-binding transcription factor activity
HN018_22400	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_22420	COG3436	PFAM IS66 Orf2 family protein
HN018_22425	COG4372	Transposase
HN018_22450	COG2801	Transposase and inactivated derivatives
HN018_22470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HN018_22485	COG0776	regulation of translation
HN018_22505	COG3706	GGDEF domain
HN018_22510	COG2198	Histidine kinase
HN018_22510	COG0784	Response regulator, receiver
HN018_22510	COG2205	protein histidine kinase activity
HN018_22510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HN018_22555	COG2201	protein-glutamate methylesterase activity
HN018_22560	COG2202	Pas domain
HN018_22560	COG3920	Histidine kinase
HN018_22565	COG4191	Histidine kinase
HN018_22565	COG0784	Response regulator, receiver
HN018_22590	COG4584	PFAM Integrase catalytic
HN018_22595	COG1484	DNA-dependent DNA replication
HN018_22600	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HN018_22605	COG4251	negative regulation of phosphorylation
HN018_22640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_22650	COG0601	transmembrane transport
HN018_22655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HN018_22670	COG0673	inositol 2-dehydrogenase activity
HN018_22680	COG0444	Belongs to the ABC transporter superfamily
HN018_22690	COG4206	TonB-dependent receptor
HN018_22710	COG0587	DNA-directed DNA polymerase activity
HN018_22745	COG0582	viral genome integration into host DNA
HN018_22800	COG3436	PFAM IS66 Orf2 family protein
HN018_22840	COG1802	Transcriptional regulator
HN018_22880	COG2072	flavoprotein involved in K transport
HN018_22895	COG0765	amino acid transport
HN018_22900	COG4597	amino acid ABC transporter
HN018_22910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HN018_22925	COG1126	abc transporter atp-binding protein
HN018_22930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HN018_22945	COG2188	Transcriptional regulator
HN018_22955	COG0473	3-isopropylmalate dehydrogenase activity
HN018_22970	COG1012	belongs to the aldehyde dehydrogenase family
HN018_22995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_23000	COG0583	DNA-binding transcription factor activity
HN018_23005	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HN018_23010	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_23020	COG2140	Oxalate decarboxylase
HN018_23040	COG2706	6-phosphogluconolactonase activity
HN018_23045	COG2271	Major facilitator Superfamily
HN018_23060	COG1012	belongs to the aldehyde dehydrogenase family
HN018_23070	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_23085	COG4372	Transposase
HN018_23090	COG3436	PFAM IS66 Orf2 family protein
HN018_23165	COG1484	DNA-dependent DNA replication
HN018_23170	COG2390	Transcriptional regulator
HN018_23170	COG4584	PFAM Integrase catalytic
HN018_23185	COG3395	kinase activity
HN018_23205	COG0473	3-isopropylmalate dehydrogenase activity
HN018_23210	COG2706	6-phosphogluconolactonase activity
HN018_23520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HN018_23525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HN018_23550	COG2135	peptidase activity
HN018_23575	COG0629	single-stranded DNA binding
HN018_23610	COG1475	DNA binding
HN018_23620	COG4974	Belongs to the 'phage' integrase family
HN018_23625	COG4974	Belongs to the 'phage' integrase family
HN018_23630	COG4974	Belongs to the 'phage' integrase family
HN018_23715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HN018_23745	COG0210	DNA helicase
HN018_23765	COG1487	ribonuclease activity
HN018_23815	COG3436	PFAM IS66 Orf2 family protein
HN018_23820	COG2433	Pfam Transposase IS66
HN018_23835	COG3264	Mechanosensitive ion channel
HN018_23835	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HN018_23840	COG4372	Transposase
HN018_23845	COG3436	PFAM IS66 Orf2 family protein
HN018_23860	COG5001	Diguanylate cyclase
HN018_23865	COG5001	Diguanylate cyclase
HN018_23895	COG5487	UPF0391 membrane protein
HN018_24005	COG1295	ribonuclease BN
HN018_24035	COG2323	membrane
HN018_24055	COG3387	PFAM Glycoside hydrolase 15-related
HN018_24065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HN018_24070	COG1845	cytochrome c oxidase, subunit III
HN018_24105	COG1192	Involved in chromosome partitioning
HN018_24145	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HN018_24240	COG0629	single-stranded DNA binding
HN018_24285	COG4584	PFAM Integrase catalytic
HN018_24290	COG1484	DNA-dependent DNA replication
HN018_24345	COG0800	Aldolase
HN018_24350	COG2140	Oxalate decarboxylase
HN018_24355	COG1879	ABC-type sugar transport system periplasmic component
HN018_24360	COG1129	ABC transporter
HN018_24365	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_24375	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_24390	COG0583	DNA-binding transcription factor activity
HN018_24395	COG0604	alcohol dehydrogenase
HN018_24395	COG3321	synthase
HN018_24405	COG2514	catechol 2,3-dioxygenase activity
HN018_24415	COG2207	Transcriptional regulator
HN018_24420	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_24440	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_24495	COG1970	mechanosensitive ion channel activity
HN018_24500	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HN018_24530	COG1484	DNA-dependent DNA replication
HN018_24535	COG4584	PFAM Integrase catalytic
HN018_24565	COG0583	DNA-binding transcription factor activity
HN018_24575	COG2814	Major facilitator Superfamily
HN018_24585	COG2249	NAD(P)H dehydrogenase (quinone) activity
HN018_24590	COG1012	belongs to the aldehyde dehydrogenase family
HN018_24600	COG2826	transposase and inactivated derivatives, IS30 family
HN018_24615	COG4221	oxidoreductase activity
HN018_24630	COG0477	Major facilitator Superfamily
HN018_24645	COG0028	Belongs to the TPP enzyme family
HN018_24655	COG4566	intracellular signal transduction
HN018_24665	COG0783	Belongs to the Dps family
HN018_24685	COG4191	Histidine kinase
HN018_24715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HN018_24730	COG2433	Pfam Transposase IS66
HN018_24735	COG3436	PFAM IS66 Orf2 family protein
HN018_24740	COG2963	transposase activity
HN018_24750	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_24765	COG3547	Transposase (IS116 IS110 IS902 family)
HN018_24775	COG3547	Transposase (IS116 IS110 IS902 family)
HN018_24780	COG4584	PFAM Integrase catalytic
HN018_24785	COG1484	DNA-dependent DNA replication
HN018_24905	COG3706	GGDEF domain
HN018_24925	COG0776	regulation of translation
HN018_24935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HN018_24950	COG4957	zinc ion binding
HN018_24965	COG2801	Transposase and inactivated derivatives
HN018_25095	COG4221	oxidoreductase activity
HN018_25170	COG5001	Diguanylate cyclase
HN018_25245	COG1982	Orn Lys Arg decarboxylase major
HN018_25260	COG1945	arginine decarboxylase activity
HN018_25285	COG0004	ammonium transporteR
HN018_25305	COG0586	Pfam SNARE associated Golgi protein
HN018_25310	COG0563	adenylate kinase activity
HN018_25315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HN018_25315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HN018_25330	COG1053	succinate dehydrogenase
HN018_25335	COG0492	ferredoxin-NADP+ reductase activity
HN018_25340	COG0517	IMP dehydrogenase activity
HN018_25345	COG0745	RESPONSE REGULATOR receiver
HN018_25350	COG0784	Response regulator, receiver
HN018_25350	COG4191	Histidine kinase
HN018_25375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HN018_25390	COG1902	pentaerythritol trinitrate reductase activity
HN018_25395	COG0443	Heat shock 70 kDa protein
HN018_25425	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HN018_25445	COG3052	prosthetic group binding
HN018_25455	COG0679	Auxin Efflux Carrier
HN018_25465	COG1554	hydrolase, family 65, central catalytic
HN018_25470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HN018_25495	COG0330	HflC and HflK could
HN018_25525	COG2326	polyphosphate kinase activity
HN018_25560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HN018_25565	COG0149	triose-phosphate isomerase activity
HN018_25585	COG3459	Glycosyltransferase 36 associated
HN018_25620	COG0406	alpha-ribazole phosphatase activity
HN018_25625	COG3588	fructose-bisphosphate aldolase
HN018_25630	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HN018_25635	COG0837	glucose binding
HN018_25645	COG0149	triose-phosphate isomerase activity
HN018_25665	COG2271	Major facilitator Superfamily
HN018_25670	COG3265	gluconokinase activity
HN018_25715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HN018_25730	COG4372	Transposase
HN018_25735	COG3436	PFAM IS66 Orf2 family protein
HN018_25750	COG0698	ribose 5-phosphate isomerase
HN018_25790	COG1064	alcohol dehydrogenase
HN018_25805	COG0628	permease
HN018_25860	COG0375	protein maturation
HN018_25875	COG3259	Nickel-dependent hydrogenase
HN018_25880	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
HN018_25890	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HN018_25900	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HN018_25945	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HN018_25975	COG1475	DNA binding
HN018_25980	COG1192	Involved in chromosome partitioning
HN018_25990	COG1484	DNA-dependent DNA replication
HN018_26025	COG2894	cell division
HN018_26055	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HN018_26080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN018_26105	COG1392	Phosphate transport regulator
HN018_26135	COG3293	Transposase
HN018_26140	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_26145	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_26150	COG1129	ABC transporter
HN018_26155	COG1879	ABC-type sugar transport system periplasmic component
HN018_26190	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HN018_26230	COG4214	carbohydrate transport
HN018_26270	COG1484	DNA-dependent DNA replication
HN018_26310	COG2205	protein histidine kinase activity
HN018_26315	COG0745	RESPONSE REGULATOR receiver
HN018_26320	COG2853	Lipoprotein
HN018_26330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN018_26345	COG4584	PFAM Integrase catalytic
HN018_26345	COG2390	Transcriptional regulator
HN018_26385	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_26410	COG3293	Transposase
HN018_26435	COG4372	Transposase
HN018_26440	COG3436	PFAM IS66 Orf2 family protein
HN018_26445	COG2826	transposase and inactivated derivatives, IS30 family
HN018_26480	COG4372	Transposase
HN018_26485	COG3436	PFAM IS66 Orf2 family protein
HN018_26490	COG2963	transposase activity
HN018_26495	COG4251	negative regulation of phosphorylation
HN018_26500	COG4251	negative regulation of phosphorylation
HN018_26510	COG5001	Diguanylate cyclase
HN018_26525	COG4584	PFAM Integrase catalytic
HN018_26530	COG1484	DNA-dependent DNA replication
HN018_26535	COG2801	Transposase and inactivated derivatives
HN018_26545	COG0784	Response regulator, receiver
HN018_26545	COG4191	Histidine kinase
HN018_26560	COG1733	regulation of RNA biosynthetic process
HN018_26585	COG0745	RESPONSE REGULATOR receiver
HN018_26605	COG4372	Transposase
HN018_26610	COG3436	PFAM IS66 Orf2 family protein
HN018_26620	COG0025	NhaP-type Na H and K H
HN018_26625	COG0025	NhaP-type Na H and K H
HN018_26630	COG0025	NhaP-type Na H and K H
HN018_26660	COG0477	Major facilitator Superfamily
HN018_26665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HN018_26670	COG3384	dioxygenase
HN018_26675	COG0583	DNA-binding transcription factor activity
HN018_26800	COG3436	PFAM IS66 Orf2 family protein
HN018_26805	COG2433	Pfam Transposase IS66
HN018_26815	COG0745	RESPONSE REGULATOR receiver
HN018_26820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HN018_26825	COG0784	Response regulator, receiver
HN018_26825	COG2205	protein histidine kinase activity
HN018_26830	COG5001	Diguanylate cyclase
HN018_26850	COG1566	PFAM secretion protein HlyD family protein
HN018_26855	COG2814	Major facilitator Superfamily
HN018_26905	COG0784	Response regulator, receiver
HN018_26905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HN018_26905	COG2198	Histidine kinase
HN018_26905	COG2205	protein histidine kinase activity
HN018_26930	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HN018_26955	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HN018_26955	COG3264	Mechanosensitive ion channel
HN018_26995	COG3702	type iv secretory pathway
HN018_27000	COG3451	type IV secretory pathway VirB4
HN018_27020	COG3736	Type IV secretory pathway, component VirB8
HN018_27035	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HN018_27040	COG3505	Type IV secretory pathway VirD4
HN018_27080	COG1505	serine-type exopeptidase activity
HN018_27120	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HN018_27135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HN018_27200	COG3436	PFAM IS66 Orf2 family protein
HN018_27205	COG4372	Transposase
HN018_27265	COG1522	sequence-specific DNA binding
HN018_27275	COG3158	transport of potassium into the cell
HN018_27320	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_27350	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HN018_27355	COG2205	protein histidine kinase activity
HN018_27360	COG0745	RESPONSE REGULATOR receiver
HN018_27450	COG1475	DNA binding
HN018_27500	COG4584	PFAM Integrase catalytic
HN018_27505	COG1484	DNA-dependent DNA replication
HN018_27580	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_27590	COG2376	Dihydroxyacetone kinase
HN018_27600	COG2390	Transcriptional regulator
HN018_27610	COG1454	alcohol dehydrogenase
HN018_27630	COG0583	DNA-binding transcription factor activity
HN018_27690	COG0776	regulation of translation
HN018_27720	COG0583	DNA-binding transcription factor activity
HN018_27770	COG5001	Diguanylate cyclase
HN018_27770	COG4251	negative regulation of phosphorylation
HN018_27770	COG3706	GGDEF domain
HN018_27770	COG2203	Gaf domain
HN018_27805	COG4214	carbohydrate transport
HN018_27845	COG4584	PFAM Integrase catalytic
HN018_27850	COG1484	DNA-dependent DNA replication
HN018_27860	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_27865	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_27890	COG2814	Major facilitator Superfamily
HN018_27910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HN018_27930	COG2202	Pas domain
HN018_27930	COG3920	Histidine kinase
HN018_27935	COG2201	protein-glutamate methylesterase activity
HN018_28035	COG0028	Belongs to the TPP enzyme family
HN018_28085	COG3702	type iv secretory pathway
HN018_28090	COG3451	type IV secretory pathway VirB4
HN018_28115	COG3736	Type IV secretory pathway, component VirB8
HN018_28130	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HN018_28135	COG3505	Type IV secretory pathway VirD4
HN018_28160	COG2184	nucleotidyltransferase activity
HN018_28185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HN018_28205	COG1475	DNA binding
HN018_28210	COG1192	Involved in chromosome partitioning
HN018_28230	COG3586	endonuclease activity
HN018_28235	COG4974	Belongs to the 'phage' integrase family
HN018_28300	COG1476	TRANSCRIPTIONal
HN018_28325	COG2826	transposase and inactivated derivatives, IS30 family