locus-tag	class	description
N5W20_00015	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
N5W20_00025	COG1216	Glycosyl transferase, family 2
N5W20_00030	COG0564	pseudouridine synthase activity
N5W20_00035	COG1674	ftsk spoiiie
N5W20_00040	COG0742	ribosomal rna small subunit methyltransferase
N5W20_00045	COG1187	pseudouridine synthase activity
N5W20_00050	COG0590	tRNA wobble adenosine to inosine editing
N5W20_00055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N5W20_00060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N5W20_00075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N5W20_00090	COG1054	Belongs to the UPF0176 family
N5W20_00110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N5W20_00135	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
N5W20_00145	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N5W20_00145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N5W20_00185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N5W20_00200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N5W20_00205	COG0588	phosphoglycerate mutase activity
N5W20_00210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N5W20_00215	COG0193	aminoacyl-tRNA hydrolase activity
N5W20_00220	COG0012	GTP binding
N5W20_00225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N5W20_00235	COG0799	negative regulation of ribosome biogenesis
N5W20_00240	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N5W20_00250	COG0251	oxidation-reduction process
N5W20_00255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N5W20_00270	COG1522	sequence-specific DNA binding
N5W20_00275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N5W20_00285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N5W20_00295	COG3956	TIGRFAM MazG family protein
N5W20_00300	COG1113	amino acid transport
N5W20_00305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N5W20_00320	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
N5W20_00325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N5W20_00335	COG0564	pseudouridine synthase activity
N5W20_00350	COG1902	pentaerythritol trinitrate reductase activity
N5W20_00355	COG0646	methionine synthase
N5W20_00355	COG1410	methionine synthase
N5W20_00380	COG1216	Glycosyl transferase, family 2
N5W20_00390	COG0438	transferase activity, transferring glycosyl groups
N5W20_00395	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N5W20_00410	COG0488	(ABC) transporter
N5W20_00425	COG2853	Lipoprotein
N5W20_00430	COG0484	heat shock protein binding
N5W20_00445	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N5W20_00450	COG0343	queuine tRNA-ribosyltransferase activity
N5W20_00455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N5W20_00465	COG3180	Ammonia monooxygenase
N5W20_00480	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
N5W20_00505	COG3634	alkyl hydroperoxide reductase activity
N5W20_00510	COG2814	Major facilitator Superfamily
N5W20_00525	COG0697	spore germination
N5W20_00555	COG0783	Belongs to the Dps family
N5W20_00560	COG2814	Major facilitator Superfamily
N5W20_00565	COG1216	Glycosyl transferase, family 2
N5W20_00565	COG0438	transferase activity, transferring glycosyl groups
N5W20_00570	COG0573	inorganic phosphate transmembrane transporter activity
N5W20_00580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N5W20_00590	COG0745	RESPONSE REGULATOR receiver
N5W20_00600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N5W20_00605	COG1301	dicarboxylic acid transport
N5W20_00610	COG1113	amino acid transport
N5W20_00630	COG3001	Fructosamine kinase
N5W20_00635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N5W20_00640	COG0829	nickel cation binding
N5W20_00645	COG0831	urea catabolic process
N5W20_00650	COG0832	Belongs to the urease beta subunit family
N5W20_00655	COG0804	urea catabolic process
N5W20_00660	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
N5W20_00665	COG0830	nickel cation binding
N5W20_00670	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N5W20_00675	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
N5W20_00685	COG0583	DNA-binding transcription factor activity
N5W20_00700	COG0495	leucyl-tRNA aminoacylation
N5W20_00715	COG1028	Short-chain dehydrogenase reductase Sdr
N5W20_00720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N5W20_00730	COG0444	Belongs to the ABC transporter superfamily
N5W20_00735	COG4608	Belongs to the ABC transporter superfamily
N5W20_00755	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
N5W20_00760	COG2894	cell division
N5W20_00765	COG0850	regulation of cytokinetic process
N5W20_00775	COG0693	protein deglycase activity
N5W20_00795	COG5002	protein histidine kinase activity
N5W20_00815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N5W20_00820	COG0081	regulation of translation
N5W20_00825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N5W20_00830	COG0222	ribosome binding
N5W20_00835	COG0085	RNA polymerase activity
N5W20_00840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N5W20_00845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N5W20_00850	COG0049	tRNA binding
N5W20_00855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N5W20_00860	COG0051	transcription antitermination factor activity, RNA binding
N5W20_00865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N5W20_00870	COG0088	Forms part of the polypeptide exit tunnel
N5W20_00875	COG0089	rRNA binding
N5W20_00880	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N5W20_00885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N5W20_00890	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N5W20_00895	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N5W20_00900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N5W20_00905	COG0255	Belongs to the universal ribosomal protein uL29 family
N5W20_00910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N5W20_00915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N5W20_00920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N5W20_00925	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N5W20_00930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N5W20_00935	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N5W20_00940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N5W20_00945	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N5W20_00950	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N5W20_00955	COG1841	ribosomal large subunit assembly
N5W20_00960	COG0200	Binds to the 23S rRNA
N5W20_00970	COG0563	adenylate kinase activity
N5W20_00975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N5W20_00980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N5W20_00985	COG0202	RNA polymerase activity
N5W20_00990	COG0203	ribosomal protein L17
N5W20_01015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5W20_01025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N5W20_01030	COG2189	Belongs to the N(4) N(6)-methyltransferase family
N5W20_01055	COG0714	Associated with various cellular activities
N5W20_01070	COG1132	(ABC) transporter
N5W20_01075	COG0494	nUDIX hydrolase
N5W20_01080	COG0793	Belongs to the peptidase S41A family
N5W20_01085	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N5W20_01095	COG0612	Peptidase, M16
N5W20_01110	COG0009	L-threonylcarbamoyladenylate synthase
N5W20_01120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5W20_01135	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N5W20_01145	COG0246	Mannitol dehydrogenase
N5W20_01165	COG1028	Short-chain dehydrogenase reductase Sdr
N5W20_01195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N5W20_01195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N5W20_01200	COG0747	negative chemotaxis
N5W20_01215	COG1570	exodeoxyribonuclease VII activity
N5W20_01225	COG1530	ribonuclease E activity
N5W20_01230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N5W20_01250	COG0768	penicillin binding
N5W20_01255	COG0772	Belongs to the SEDS family
N5W20_01260	COG0751	glycine-tRNA ligase activity
N5W20_01265	COG0752	glycyl-tRNA synthetase alpha subunit
N5W20_01280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N5W20_01285	COG0708	Exodeoxyribonuclease III
N5W20_01290	COG0316	Belongs to the HesB IscA family
N5W20_01295	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N5W20_01300	COG0018	arginyl-trna synthetase
N5W20_01310	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N5W20_01315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N5W20_01320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N5W20_01325	COG0805	protein transport
N5W20_01330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N5W20_01365	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
N5W20_01380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N5W20_01385	COG1183	phosphatidylcholine synthase activity
N5W20_01390	COG0688	phosphatidylethanolamine metabolic process
N5W20_01400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N5W20_01410	COG0204	Acyl-transferase
N5W20_01435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
N5W20_01440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N5W20_01455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N5W20_01460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N5W20_01465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N5W20_01470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N5W20_01470	COG0072	phenylalanine-tRNA ligase activity
N5W20_01475	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N5W20_01480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N5W20_01485	COG0354	folic acid binding
N5W20_01535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N5W20_01570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N5W20_01580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N5W20_01585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N5W20_01590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N5W20_01650	COG0156	8-amino-7-oxononanoate synthase activity
N5W20_01655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N5W20_01660	COG0318	PFAM AMP-dependent synthetase and ligase
N5W20_01710	COG1169	isochorismate synthase
N5W20_01715	COG3433	isochorismatase activity
N5W20_01715	COG1535	isochorismatase
N5W20_01720	COG1028	Short-chain dehydrogenase reductase Sdr
N5W20_01730	COG1132	(ABC) transporter
N5W20_01740	COG1021	2,3-dihydroxybenzoate-AMP ligase
N5W20_01760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N5W20_01760	COG3433	isochorismatase activity
N5W20_01760	COG2226	methyltransferase
N5W20_01770	COG4771	TonB-dependent receptor
N5W20_01775	COG1959	2 iron, 2 sulfur cluster binding
N5W20_01780	COG1017	nitric oxide dioxygenase activity
N5W20_01780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N5W20_01815	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N5W20_01850	COG0583	DNA-binding transcription factor activity
N5W20_01860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N5W20_01865	COG0228	four-way junction DNA binding
N5W20_01870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N5W20_01875	COG0336	Belongs to the RNA methyltransferase TrmD family
N5W20_01880	COG0335	large ribosomal subunit rRNA binding
N5W20_01885	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N5W20_01890	COG0066	3-isopropylmalate dehydratase activity
N5W20_01895	COG0473	3-isopropylmalate dehydrogenase activity
N5W20_01900	COG0436	Aminotransferase
N5W20_01905	COG0436	Aminotransferase
N5W20_01930	COG1297	OPT oligopeptide transporter protein
N5W20_01940	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N5W20_01945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N5W20_01950	COG0328	RNA-DNA hybrid ribonuclease activity
N5W20_01970	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N5W20_02000	COG1253	flavin adenine dinucleotide binding
N5W20_02005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N5W20_02010	COG0497	DNA recombination
N5W20_02015	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N5W20_02035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N5W20_02040	COG1181	Belongs to the D-alanine--D-alanine ligase family
N5W20_02045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N5W20_02050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N5W20_02055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N5W20_02065	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N5W20_02070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N5W20_02075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N5W20_02080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N5W20_02095	COG0275	rRNA processing
N5W20_02100	COG2001	Belongs to the MraZ family
N5W20_02115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N5W20_02120	COG3750	Belongs to the UPF0335 family
N5W20_02130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N5W20_02135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N5W20_02140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N5W20_02145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N5W20_02160	COG1289	transmembrane transporter activity
N5W20_02165	COG1573	uracil-dna glycosylase
N5W20_02170	COG4957	zinc ion binding
N5W20_02175	COG0776	regulation of translation
N5W20_02180	COG0583	DNA-binding transcription factor activity
N5W20_02185	COG0492	ferredoxin-NADP+ reductase activity
N5W20_02190	COG1522	sequence-specific DNA binding
N5W20_02195	COG0463	Glycosyl transferase, family 2
N5W20_02205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N5W20_02210	COG1846	Transcriptional regulator
N5W20_02215	COG0745	RESPONSE REGULATOR receiver
N5W20_02235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N5W20_02240	COG0416	fatty acid biosynthetic process
N5W20_02245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N5W20_02265	COG0628	permease
N5W20_02275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N5W20_02280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N5W20_02295	COG2733	membrane
N5W20_02305	COG0719	Fe-S assembly protein
N5W20_02310	COG0396	ATPase activity
N5W20_02315	COG0719	Fe-S assembly protein
N5W20_02320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N5W20_02325	COG2151	metal-sulfur cluster biosynthetic enzyme
N5W20_02330	COG0316	Belongs to the HesB IscA family
N5W20_02340	COG0513	Belongs to the DEAD box helicase family
N5W20_02350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N5W20_02350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N5W20_02360	COG0544	peptidyl-prolyl cis-trans isomerase activity
N5W20_02365	COG0740	serine-type endopeptidase activity
N5W20_02370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N5W20_02380	COG0776	regulation of translation
N5W20_02395	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
N5W20_02405	COG0442	prolyl-tRNA aminoacylation
N5W20_02410	COG4591	ABC-type transport system involved in lipoprotein release permease component
N5W20_02415	COG1136	(ABC) transporter
N5W20_02425	COG0052	Belongs to the universal ribosomal protein uS2 family
N5W20_02430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N5W20_02435	COG1381	Involved in DNA repair and RecF pathway recombination
N5W20_02440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N5W20_02445	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
N5W20_02450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N5W20_02460	COG0628	permease
N5W20_02465	COG0626	cystathionine gamma-synthase activity
N5W20_02475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N5W20_02480	COG0483	inositol monophosphate 1-phosphatase activity
N5W20_02485	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
N5W20_02490	COG0077	Prephenate dehydratase
N5W20_02490	COG1605	Chorismate mutase
N5W20_02495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N5W20_02500	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N5W20_02525	COG5001	Diguanylate cyclase
N5W20_02525	COG3300	MHYT domain
N5W20_02530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N5W20_02535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N5W20_02540	COG0583	DNA-binding transcription factor activity
N5W20_02545	COG3961	Belongs to the TPP enzyme family
N5W20_02575	COG0321	lipoyl(octanoyl) transferase activity
N5W20_02595	COG1040	competence protein
N5W20_02600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N5W20_02610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N5W20_02615	COG0527	aspartate kinase activity
N5W20_02620	COG2070	2-Nitropropane dioxygenase
N5W20_02625	COG1426	Protein conserved in bacteria
N5W20_02630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N5W20_02635	COG0124	histidyl-tRNA synthetase
N5W20_02640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N5W20_02650	COG2890	protein-(glutamine-N5) methyltransferase activity
N5W20_02700	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N5W20_02705	COG0154	amidase activity
N5W20_02710	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N5W20_02715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N5W20_02720	COG0473	3-isopropylmalate dehydrogenase activity
N5W20_02725	COG0006	proline dipeptidase activity
N5W20_02735	COG2264	protein methyltransferase activity
N5W20_02745	COG2003	Belongs to the UPF0758 family
N5W20_02755	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N5W20_02770	COG0071	Belongs to the small heat shock protein (HSP20) family
N5W20_02775	COG0254	rRNA binding
N5W20_02780	COG1970	mechanosensitive ion channel activity
N5W20_02790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N5W20_02795	COG0673	inositol 2-dehydrogenase activity
N5W20_02800	COG0488	(ABC) transporter
N5W20_02805	COG0784	Response regulator, receiver
N5W20_02830	COG4988	ABC transporter
N5W20_02835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N5W20_02845	COG0514	ATP-dependent DNA helicase (RecQ)
N5W20_02855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N5W20_02860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N5W20_02865	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N5W20_02880	COG0837	glucose binding
N5W20_02885	COG3023	N-Acetylmuramoyl-L-alanine amidase
N5W20_02935	COG0525	valine-tRNA ligase activity
N5W20_02940	COG0129	dihydroxy-acid dehydratase activity
N5W20_02950	COG1116	anion transmembrane transporter activity
N5W20_02960	COG0756	dUTP diphosphatase activity
N5W20_02965	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N5W20_02970	COG2226	methyltransferase
N5W20_02975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N5W20_02980	COG0268	Binds directly to 16S ribosomal RNA
N5W20_02985	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N5W20_02995	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N5W20_03010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N5W20_03015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N5W20_03030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N5W20_03030	COG0321	lipoyl(octanoyl) transferase activity
N5W20_03035	COG0084	hydrolase, TatD family'
N5W20_03040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N5W20_03045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N5W20_03050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N5W20_03055	COG1686	Belongs to the peptidase S11 family
N5W20_03065	COG2951	lytic endotransglycosylase activity
N5W20_03075	COG1968	undecaprenyl-diphosphatase activity
N5W20_03080	COG0531	amino acid
N5W20_03105	COG0513	Belongs to the DEAD box helicase family
N5W20_03110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N5W20_03115	COG0531	amino acid
N5W20_03120	COG0113	porphobilinogen synthase activity
N5W20_03125	COG0792	nuclease activity
N5W20_03135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N5W20_03140	COG0271	Belongs to the BolA IbaG family
N5W20_03145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N5W20_03150	COG0047	phosphoribosylformylglycinamidine synthase activity
N5W20_03160	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N5W20_03165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N5W20_03170	COG2814	Major facilitator Superfamily
N5W20_03175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N5W20_03180	COG0861	Integral membrane protein TerC family
N5W20_03185	COG0741	lytic transglycosylase activity
N5W20_03205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N5W20_03210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N5W20_03215	COG0508	dehydrogenase complex catalyzes the overall conversion of
N5W20_03220	COG0508	dehydrogenase complex catalyzes the overall conversion of
N5W20_03220	COG0022	dehydrogenase e1 component
N5W20_03225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N5W20_03230	COG0134	indole-3-glycerol-phosphate synthase activity
N5W20_03235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N5W20_03245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N5W20_03260	COG0504	CTP synthase activity
N5W20_03265	COG2877	3-deoxy-8-phosphooctulonate synthase activity
N5W20_03270	COG0148	phosphopyruvate hydratase activity
N5W20_03280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N5W20_03285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N5W20_03295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N5W20_03300	COG0322	excinuclease ABC activity
N5W20_03310	COG0745	RESPONSE REGULATOR receiver
N5W20_03325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N5W20_03325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N5W20_03335	COG0542	response to heat
N5W20_03340	COG2814	Major facilitator Superfamily
N5W20_03345	COG2942	2-epimerase
N5W20_03355	COG0138	bifunctional purine biosynthesis protein purh
N5W20_03365	COG1566	PFAM secretion protein HlyD family protein
N5W20_03380	COG1069	ribulokinase activity
N5W20_03385	COG1028	Short-chain dehydrogenase reductase Sdr
N5W20_03390	COG0625	glutathione transferase activity
N5W20_03395	COG0513	Belongs to the DEAD box helicase family
N5W20_03400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N5W20_03400	COG2813	Specifically methylates the guanine in position
N5W20_03405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N5W20_03410	COG0655	NAD(P)H dehydrogenase (quinone) activity
N5W20_03415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N5W20_03445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N5W20_03450	COG0288	reversible hydration of carbon dioxide
N5W20_03465	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N5W20_03475	COG2376	Dihydroxyacetone kinase
N5W20_03490	COG1349	DNA-binding transcription factor activity
N5W20_03495	COG1064	alcohol dehydrogenase
N5W20_03510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N5W20_03515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5W20_03520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N5W20_03545	COG0167	dihydroorotate dehydrogenase activity
N5W20_03550	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N5W20_03550	COG3264	Mechanosensitive ion channel
N5W20_03560	COG0778	Nitroreductase
N5W20_03565	COG0131	Imidazoleglycerol-phosphate dehydratase
N5W20_03570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N5W20_03580	COG0107	imidazoleglycerol-phosphate synthase activity
N5W20_03585	COG0140	phosphoribosyl-ATP diphosphatase activity
N5W20_03730	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
N5W20_03770	COG2217	Heavy metal translocating P-type atpase
N5W20_03790	COG2022	thiamine diphosphate biosynthetic process
N5W20_03830	COG1942	4-Oxalocrotonate Tautomerase
N5W20_03835	COG3718	enzyme involved in inositol metabolism
N5W20_03840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N5W20_03865	COG0477	Major facilitator Superfamily
N5W20_03865	COG2814	Major facilitator Superfamily
N5W20_03875	COG0673	inositol 2-dehydrogenase activity
N5W20_03880	COG2814	Major facilitator Superfamily
N5W20_03890	COG0028	Belongs to the TPP enzyme family
N5W20_03915	COG1028	Short-chain dehydrogenase reductase Sdr
N5W20_03920	COG0277	FAD linked oxidase domain protein
N5W20_03920	COG0247	lactate metabolic process
N5W20_03930	COG4651	solute:proton antiporter activity
N5W20_03930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N5W20_03940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N5W20_03945	COG1845	cytochrome c oxidase, subunit III
N5W20_03960	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N5W20_03965	COG1940	carbohydrate kinase activity
N5W20_03975	COG1722	exodeoxyribonuclease VII activity
N5W20_03980	COG0142	geranyltranstransferase activity
N5W20_03985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N5W20_03990	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
N5W20_03995	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N5W20_04000	COG0137	argininosuccinate synthase activity
N5W20_04005	COG0545	Peptidyl-prolyl cis-trans isomerase
N5W20_04015	COG0180	Tryptophanyl-tRNA synthetase
N5W20_04020	COG0432	Pfam Uncharacterised protein family UPF0047
N5W20_04030	COG3781	membrane
N5W20_04035	COG1329	Transcriptional regulator
N5W20_04040	COG1028	Short-chain dehydrogenase reductase Sdr
N5W20_04045	COG0745	RESPONSE REGULATOR receiver
N5W20_04065	COG0204	Acyl-transferase
N5W20_04070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N5W20_04075	COG1702	phosphate starvation-inducible protein PhoH
N5W20_04080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N5W20_04095	COG1196	nuclear chromosome segregation
N5W20_04100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N5W20_04105	COG0287	Prephenate dehydrogenase
N5W20_04105	COG1605	Chorismate mutase
N5W20_04125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N5W20_04130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N5W20_04135	COG0142	geranyltranstransferase activity
N5W20_04145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N5W20_04150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N5W20_04150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N5W20_04155	COG1764	response to oxidative stress
N5W20_04160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N5W20_04165	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N5W20_04170	COG0259	pyridoxamine-phosphate oxidase activity
N5W20_04180	COG1519	Transferase
N5W20_04185	COG1663	tetraacyldisaccharide 4'-kinase activity
N5W20_04205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N5W20_04215	COG3572	ergothioneine biosynthetic process
N5W20_04220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N5W20_04225	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N5W20_04230	COG2814	Major facilitator Superfamily
N5W20_04240	COG1160	GTP binding
N5W20_04245	COG2010	Cytochrome c
N5W20_04245	COG4993	Dehydrogenase
N5W20_04265	COG0367	asparagine synthase
N5W20_04270	COG0438	transferase activity, transferring glycosyl groups
N5W20_04285	COG0237	dephospho-CoA kinase activity
N5W20_04290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N5W20_04300	COG0165	Argininosuccinate lyase
N5W20_04310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N5W20_04320	COG1393	Belongs to the ArsC family
N5W20_04335	COG0519	Catalyzes the synthesis of GMP from XMP
N5W20_04335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N5W20_04370	COG3591	Belongs to the peptidase S1B family
N5W20_04375	COG0019	diaminopimelate decarboxylase activity
N5W20_04385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N5W20_04390	COG0248	Ppx GppA phosphatase
N5W20_04395	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N5W20_04405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N5W20_04410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N5W20_04415	COG0105	UTP biosynthetic process
N5W20_04420	COG0488	(ABC) transporter
N5W20_04440	COG1086	Polysaccharide biosynthesis protein
N5W20_04445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N5W20_04455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N5W20_04485	COG1845	cytochrome c oxidase, subunit III
N5W20_04500	COG0670	Belongs to the BI1 family
N5W20_04510	COG0392	lysyltransferase activity
N5W20_04520	COG1199	ATP-dependent helicase activity
N5W20_04525	COG0459	protein refolding
N5W20_04530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N5W20_04540	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
N5W20_04545	COG0408	coproporphyrinogen oxidase activity
N5W20_04560	COG1858	cytochrome C peroxidase
N5W20_04580	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
N5W20_04610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N5W20_04615	COG0181	hydroxymethylbilane synthase activity
N5W20_04625	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N5W20_04630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N5W20_04645	COG0386	Belongs to the glutathione peroxidase family
N5W20_04655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N5W20_04660	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N5W20_04680	COG0612	Peptidase, M16
N5W20_04685	COG0312	modulator of DNA gyrase
N5W20_04695	COG0109	protoheme IX farnesyltransferase activity
N5W20_04705	COG2226	methyltransferase
N5W20_04715	COG0189	ligase activity
N5W20_04730	COG0556	nucleotide-excision repair
N5W20_04750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N5W20_04755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N5W20_04765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N5W20_04770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N5W20_04795	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N5W20_04795	COG0517	IMP dehydrogenase activity
N5W20_04810	COG1137	ATPase activity
N5W20_04815	COG0251	oxidation-reduction process
N5W20_04830	COG0242	peptide deformylase activity
N5W20_04835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N5W20_04840	COG0101	tRNA pseudouridine synthase activity
N5W20_04850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N5W20_04855	COG2171	N-acyltransferase activity
N5W20_04865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N5W20_04870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N5W20_04875	COG0706	membrane insertase activity
N5W20_04880	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N5W20_04885	COG0594	ribonuclease P activity
N5W20_04890	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N5W20_04900	COG0346	lactoylglutathione lyase activity
N5W20_04905	COG3494	Protein of unknown function (DUF1009)
N5W20_04910	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N5W20_04915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N5W20_04920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N5W20_04930	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N5W20_04935	COG0750	zinc metalloprotease
N5W20_04940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N5W20_04950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N5W20_04955	COG0233	cytoplasmic translational termination
N5W20_04960	COG0528	UMP kinase activity
N5W20_04965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N5W20_04970	COG0571	ribonuclease III activity
N5W20_04975	COG0681	Belongs to the peptidase S26 family
N5W20_04980	COG0736	holo-[acyl-carrier-protein] synthase activity
N5W20_04985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N5W20_04990	COG1758	RNA polymerase activity
N5W20_05000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N5W20_05015	COG0494	nUDIX hydrolase
N5W20_05025	COG1058	Belongs to the CinA family
N5W20_05025	COG1546	Belongs to the CinA family
N5W20_05030	COG0825	malonyl-CoA metabolic process
N5W20_05035	COG4974	Belongs to the 'phage' integrase family
N5W20_05045	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N5W20_05050	COG2885	chlorophyll binding
N5W20_05050	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
N5W20_05060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N5W20_05065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N5W20_05070	COG0534	Mate efflux family protein
N5W20_05075	COG0215	cysteine-tRNA ligase activity
N5W20_05085	COG3265	gluconokinase activity
N5W20_05090	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N5W20_05095	COG0363	glucosamine-6-phosphate deaminase activity
N5W20_05100	COG0561	phosphatase activity
N5W20_05105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N5W20_05110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
N5W20_05115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N5W20_05130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N5W20_05145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N5W20_05155	COG0037	tRNA processing
N5W20_05165	COG2885	chlorophyll binding
N5W20_05170	COG0823	Involved in the tonB-independent uptake of proteins
N5W20_05180	COG0848	biopolymer transport protein
N5W20_05190	COG0824	Thioesterase
N5W20_05195	COG2255	four-way junction helicase activity
N5W20_05200	COG0632	four-way junction helicase activity
N5W20_05205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N5W20_05210	COG0217	transcriptional regulatory protein
N5W20_05215	COG0653	protein targeting
N5W20_05220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N5W20_05225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N5W20_05285	COG3210	domain, Protein
N5W20_05285	COG2911	Protein conserved in bacteria
N5W20_05295	COG4974	Belongs to the 'phage' integrase family
N5W20_05465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N5W20_05465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N5W20_05530	COG2814	Major facilitator Superfamily
N5W20_05535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N5W20_05535	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N5W20_05555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N5W20_05565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N5W20_05595	COG1012	belongs to the aldehyde dehydrogenase family
N5W20_05615	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
N5W20_05620	COG1138	Cytochrome C-type biogenesis protein
N5W20_05625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N5W20_05630	COG3088	subunit of a heme lyase
N5W20_05655	COG0584	glycerophosphoryl diester phosphodiesterase
N5W20_05675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N5W20_05680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N5W20_05685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N5W20_05690	COG0359	binds to the 23S rRNA
N5W20_05695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N5W20_05700	COG0360	Binds together with S18 to 16S ribosomal RNA
N5W20_05710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N5W20_05725	COG0505	Belongs to the CarA family
N5W20_05730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N5W20_05735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N5W20_05740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N5W20_05760	COG0539	negative regulation of cytoplasmic translation
N5W20_05765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N5W20_05770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N5W20_05780	COG3161	chorismate lyase activity
N5W20_05790	COG1028	Short-chain dehydrogenase reductase Sdr
N5W20_05795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N5W20_05800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N5W20_05820	COG0024	Methionine aminopeptidase
N5W20_05825	COG1686	Belongs to the peptidase S11 family
N5W20_05830	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N5W20_05840	COG0753	catalase activity
N5W20_05870	COG0482	sulfurtransferase activity
N5W20_05880	COG1104	cysteine desulfurase activity
N5W20_05885	COG1104	cysteine desulfurase activity
N5W20_05890	COG2945	thiolester hydrolase activity
N5W20_05895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N5W20_05900	COG0438	transferase activity, transferring glycosyl groups
N5W20_05910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N5W20_05920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N5W20_05925	COG3158	transport of potassium into the cell
N5W20_05930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N5W20_05945	COG1185	polyribonucleotide nucleotidyltransferase activity
N5W20_05950	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N5W20_05955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N5W20_05960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N5W20_05965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N5W20_05980	COG0779	Required for maturation of 30S ribosomal subunits
N5W20_05995	COG0542	response to heat
N5W20_06005	COG0765	amino acid transport
N5W20_06010	COG1126	abc transporter atp-binding protein
N5W20_06015	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N5W20_06020	COG4133	protoheme IX ABC transporter activity
N5W20_06030	COG0439	Biotin carboxylase
N5W20_06035	COG0511	ligase activity, forming carbon-carbon bonds
N5W20_06050	COG1295	ribonuclease BN
N5W20_06070	COG0281	malic enzyme
N5W20_06075	COG0114	fumarate hydratase activity
N5W20_06080	COG1012	belongs to the aldehyde dehydrogenase family
N5W20_06115	COG1953	Uracil, thiamine, allantoin
N5W20_06120	COG1953	Uracil, thiamine, allantoin
N5W20_06125	COG1648	precorrin-2 dehydrogenase activity
N5W20_06125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N5W20_06130	COG0175	sulfate reduction
N5W20_06135	COG0175	sulfate reduction
N5W20_06145	COG0671	phosphoesterase, PA-phosphatase related
N5W20_06150	COG0671	phosphoesterase, PA-phosphatase related
N5W20_06160	COG0156	8-amino-7-oxononanoate synthase activity
N5W20_06180	COG2376	Dihydroxyacetone kinase
N5W20_06185	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
N5W20_06195	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N5W20_06205	COG3659	wide pore channel activity
N5W20_06215	COG1797	cobyrinic acid a,c-diamide synthase activity
N5W20_06235	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
N5W20_06245	COG1914	H( )-stimulated, divalent metal cation uptake system
N5W20_06260	COG1830	Aldolase
N5W20_06310	COG0523	cobalamin synthesis protein
N5W20_06320	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
N5W20_06325	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N5W20_06340	COG1492	cobalamin metabolic process
N5W20_06345	COG0778	Nitroreductase
N5W20_06350	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
N5W20_06360	COG0602	queuosine metabolic process
N5W20_06365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N5W20_06385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N5W20_06390	COG0156	8-amino-7-oxononanoate synthase activity
N5W20_06395	COG0596	Alpha beta hydrolase
N5W20_06400	COG4106	trans-aconitate 2-methyltransferase activity
N5W20_06400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N5W20_06405	COG4106	trans-aconitate 2-methyltransferase activity
N5W20_06405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N5W20_06415	COG0438	transferase activity, transferring glycosyl groups
N5W20_06440	COG1238	metal cluster binding
N5W20_06450	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N5W20_06460	COG1573	uracil-dna glycosylase
N5W20_06465	COG0741	lytic transglycosylase activity
N5W20_06485	COG1253	flavin adenine dinucleotide binding
N5W20_06490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N5W20_06510	COG3394	polysaccharide catabolic process
N5W20_06530	COG2887	Belongs to the helicase family. UvrD subfamily
N5W20_06535	COG0802	atpase or kinase
N5W20_06540	COG0492	ferredoxin-NADP+ reductase activity
N5W20_06550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N5W20_06575	COG1217	gtp-binding protein TYPA
N5W20_06580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N5W20_06595	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N5W20_06600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N5W20_06610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N5W20_06615	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N5W20_06620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N5W20_06625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N5W20_06630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N5W20_06650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N5W20_06680	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N5W20_06695	COG3008	intermembrane lipid transfer
N5W20_06700	COG2995	paraquat-inducible protein a
N5W20_06735	COG3477	response to acidic pH
N5W20_06750	COG2271	Major facilitator Superfamily
N5W20_06755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N5W20_06900	COG1783	phage Terminase large subunit
N5W20_06930	COG4335	DNA alkylation repair
N5W20_06950	COG0351	phosphomethylpyrimidine kinase
N5W20_06980	COG0352	thiamine-phosphate diphosphorylase activity
N5W20_06985	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N5W20_06995	COG2337	Toxic component of a toxin-antitoxin (TA) module
N5W20_07025	COG1396	sequence-specific DNA binding
N5W20_07030	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N5W20_07045	COG4957	zinc ion binding
N5W20_07060	COG0778	Nitroreductase
N5W20_07120	COG0667	Aldo Keto reductase
N5W20_07275	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
N5W20_07275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N5W20_07280	COG1494	fructose-1,6-bisphosphatase
N5W20_07295	COG0436	Aminotransferase
N5W20_07310	COG0740	serine-type endopeptidase activity
N5W20_07340	COG2326	polyphosphate kinase activity
N5W20_07345	COG4221	oxidoreductase activity
N5W20_07360	COG1127	ABC transporter
N5W20_07365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N5W20_07375	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N5W20_07380	COG2814	Major facilitator Superfamily
N5W20_07390	COG0508	dehydrogenase complex catalyzes the overall conversion of
N5W20_07405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N5W20_07410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N5W20_07435	COG1611	Belongs to the LOG family
N5W20_07445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N5W20_07455	COG2353	YceI-like domain
N5W20_07500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N5W20_07505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N5W20_07515	COG1194	a g-specific adenine glycosylase
N5W20_07525	COG0415	Belongs to the DNA photolyase family
N5W20_07540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N5W20_07540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N5W20_07545	COG0307	riboflavin synthase, alpha
N5W20_07550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N5W20_07550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N5W20_07555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N5W20_07565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N5W20_07570	COG0489	protein tyrosine kinase activity
N5W20_07580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N5W20_07590	COG0246	Mannitol dehydrogenase
N5W20_07595	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
N5W20_07600	COG2943	transferase activity, transferring hexosyl groups
N5W20_07625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N5W20_07645	COG4974	Belongs to the 'phage' integrase family
N5W20_07660	COG0004	ammonium transporteR
N5W20_07665	COG0347	Belongs to the P(II) protein family
N5W20_07670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5W20_07680	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N5W20_07685	COG0285	dihydrofolate synthase activity
N5W20_07695	COG3772	lysozyme
N5W20_07705	COG2814	Major facilitator Superfamily
N5W20_07715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N5W20_07720	COG0778	Nitroreductase
N5W20_07735	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
N5W20_07745	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N5W20_07750	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N5W20_07755	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N5W20_07760	COG0356	it plays a direct role in the translocation of protons across the membrane
N5W20_07775	COG0596	Alpha beta hydrolase
N5W20_07785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N5W20_07785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N5W20_07790	COG0509	glycine decarboxylation via glycine cleavage system
N5W20_07795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N5W20_07810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N5W20_07815	COG0440	acetolactate synthase activity
N5W20_07820	COG0028	Belongs to the TPP enzyme family
N5W20_07825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N5W20_07830	COG0560	Phosphoserine phosphatase
N5W20_07850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N5W20_07855	COG0463	Glycosyl transferase, family 2
N5W20_07865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N5W20_07870	COG1120	ATPase activity
N5W20_07880	COG0735	belongs to the Fur family
N5W20_07925	COG0587	DNA-directed DNA polymerase activity
N5W20_07940	COG0762	integral membrane protein
N5W20_07950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N5W20_07955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N5W20_07980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N5W20_08015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N5W20_08035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N5W20_08055	COG0357	Ribosomal RNA small subunit methyltransferase G
N5W20_08060	COG0445	tRNA wobble uridine modification
N5W20_08065	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N5W20_08070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N5W20_08075	COG2205	protein histidine kinase activity
N5W20_08080	COG0745	RESPONSE REGULATOR receiver
N5W20_08085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N5W20_08090	COG0443	Heat shock 70 kDa protein
N5W20_08095	COG0484	heat shock protein binding
N5W20_08100	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N5W20_08105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N5W20_08110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N5W20_08130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N5W20_08140	COG0424	maF-like protein
N5W20_08145	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N5W20_08150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N5W20_08155	COG1981	membrane
N5W20_08160	COG1028	Short-chain dehydrogenase reductase Sdr
N5W20_08180	COG0628	permease
N5W20_08190	COG0848	biopolymer transport protein
N5W20_08220	COG1660	Displays ATPase and GTPase activities
N5W20_08240	COG0191	fructose-bisphosphate aldolase activity
N5W20_08255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N5W20_08260	COG0246	Mannitol dehydrogenase
N5W20_08270	COG0312	modulator of DNA gyrase
N5W20_08305	COG0159	tryptophan synthase activity
N5W20_08310	COG0133	tryptophan synthase activity
N5W20_08315	COG0326	Molecular chaperone. Has ATPase activity
N5W20_08320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N5W20_08330	COG4771	TonB-dependent receptor
N5W20_08335	COG0339	signal peptide processing
N5W20_08340	COG0656	L-ascorbic acid biosynthetic process
N5W20_08345	COG0305	Participates in initiation and elongation during chromosome replication
N5W20_08350	COG1285	pathogenesis
N5W20_08355	COG0194	GDP metabolic process
N5W20_08360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N5W20_08365	COG3047	cAMP biosynthetic process
N5W20_08370	COG2814	Major facilitator Superfamily
N5W20_08380	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N5W20_08390	COG0424	maF-like protein
N5W20_08395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N5W20_08400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N5W20_08405	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N5W20_08420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N5W20_08425	COG0717	Belongs to the dCTP deaminase family
N5W20_08435	COG0438	transferase activity, transferring glycosyl groups
N5W20_08455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N5W20_08460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N5W20_08475	COG0745	RESPONSE REGULATOR receiver
N5W20_08480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N5W20_08485	COG1643	Atp-dependent helicase
N5W20_08495	COG0179	Fumarylacetoacetate (FAA) hydrolase
N5W20_08500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N5W20_08505	COG0629	single-stranded DNA binding
N5W20_08510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N5W20_08540	COG5001	Diguanylate cyclase
N5W20_08590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N5W20_08595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N5W20_08600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N5W20_08615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N5W20_08620	COG0196	riboflavin kinase activity
N5W20_08625	COG2942	2-epimerase
N5W20_08630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N5W20_08630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N5W20_08635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N5W20_08640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N5W20_08645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N5W20_08650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N5W20_08660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N5W20_08670	COG0187	DNA topoisomerase II activity
N5W20_08685	COG1959	2 iron, 2 sulfur cluster binding
N5W20_08690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N5W20_08695	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
N5W20_08695	COG2885	chlorophyll binding
N5W20_08705	COG0793	Belongs to the peptidase S41A family
N5W20_08710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N5W20_08715	COG0758	DNA mediated transformation
N5W20_08720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N5W20_08725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N5W20_08730	COG0540	Belongs to the ATCase OTCase family
N5W20_08735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N5W20_08740	COG0658	competence protein
N5W20_08740	COG2333	competence protein COMEC
N5W20_08750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N5W20_08755	COG5265	(ABC) transporter
N5W20_08770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N5W20_08775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N5W20_08780	COG1420	regulation of RNA biosynthetic process
N5W20_08800	COG2226	methyltransferase
N5W20_08810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N5W20_08815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N5W20_08820	COG0552	protein localization to endoplasmic reticulum
N5W20_08825	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
N5W20_08830	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N5W20_08835	COG0019	diaminopimelate decarboxylase activity
N5W20_08840	COG0126	phosphoglycerate kinase activity
N5W20_08860	COG2244	polysaccharide biosynthetic process
N5W20_08865	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N5W20_08895	COG0656	L-ascorbic acid biosynthetic process
N5W20_08905	COG4774	siderophore transport
N5W20_08910	COG1120	ATPase activity
N5W20_08920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N5W20_08925	COG1028	Short-chain dehydrogenase reductase Sdr
N5W20_08935	COG1070	Carbohydrate kinase
N5W20_08945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N5W20_08950	COG0730	response to heat
N5W20_08960	COG1566	PFAM secretion protein HlyD family protein
N5W20_08965	COG2814	Major facilitator Superfamily
N5W20_08975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N5W20_08980	COG3387	PFAM Glycoside hydrolase 15-related
N5W20_08985	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5W20_08990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5W20_09010	COG1034	ATP synthesis coupled electron transport
N5W20_09015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N5W20_09020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5W20_09025	COG0839	Belongs to the complex I subunit 6 family
N5W20_09030	COG0713	ATP synthesis coupled electron transport
N5W20_09035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N5W20_09045	COG1007	ATP synthesis coupled electron transport
N5W20_09070	COG2099	Precorrin-6x reductase
N5W20_09090	COG4774	siderophore transport
N5W20_09100	COG3128	pkhd-type hydroxylase
N5W20_09125	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N5W20_09135	COG3586	endonuclease activity
N5W20_09175	COG2983	Belongs to the UPF0260 family
N5W20_09260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N5W20_09265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N5W20_09270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N5W20_09275	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N5W20_09280	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N5W20_09285	COG0302	gtp cyclohydrolase
N5W20_09295	COG2204	response regulator
N5W20_09305	COG2204	response regulator
N5W20_09315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N5W20_09330	COG0659	secondary active sulfate transmembrane transporter activity
N5W20_09340	COG2814	Major facilitator Superfamily
N5W20_09350	COG3962	Belongs to the TPP enzyme family
N5W20_09355	COG1082	Xylose isomerase domain protein TIM barrel
N5W20_09375	COG0135	phosphoribosylanthranilate isomerase activity
N5W20_09380	COG0284	orotidine-5'-phosphate decarboxylase activity
N5W20_09395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N5W20_09400	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N5W20_09405	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N5W20_09435	COG0469	pyruvate kinase activity
N5W20_09440	COG0287	Prephenate dehydrogenase
N5W20_09450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N5W20_09455	COG1562	ergosterol biosynthetic process
N5W20_09460	COG1562	ergosterol biosynthetic process
N5W20_09465	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
N5W20_09470	COG1657	PFAM Prenyltransferase squalene oxidase
N5W20_09485	COG0481	GTPase activity
N5W20_09505	COG0483	inositol monophosphate 1-phosphatase activity
N5W20_09510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N5W20_09520	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N5W20_09535	COG0352	thiamine-phosphate diphosphorylase activity
N5W20_09560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N5W20_09565	COG1692	metallophosphoesterase