locus-tag	class	description
Acear_0002	COG0592	DNA-directed DNA polymerase activity
Acear_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Acear_0007	COG0187	DNA topoisomerase II activity
Acear_0008	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Acear_0009	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Acear_0010	COG0616	signal peptide processing
Acear_0012	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Acear_0013	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Acear_0014	COG1321	iron dependent repressor
Acear_0022	COG3546	catalase activity
Acear_0026	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Acear_0027	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Acear_0028	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Acear_0030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Acear_0031	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Acear_0032	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Acear_0034	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Acear_0036	COG0674	pyruvate-flavodoxin oxidoreductase activity
Acear_0037	COG1013	pyruvate-flavodoxin oxidoreductase activity
Acear_0041	COG0516	GMP reductase activity
Acear_0041	COG0517	IMP dehydrogenase activity
Acear_0042	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Acear_0043	COG1728	Protein conserved in bacteria
Acear_0044	COG0470	DNA polymerase III
Acear_0045	COG1774	PSP1 C-terminal conserved region
Acear_0047	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Acear_0049	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Acear_0050	COG2002	toxin-antitoxin pair type II binding
Acear_0053	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acear_0053	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acear_0054	COG0084	hydrolase, TatD family'
Acear_0056	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Acear_0057	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Acear_0059	COG4466	Protein conserved in bacteria
Acear_0060	COG1414	Transcriptional regulator
Acear_0061	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Acear_0062	COG0543	2 iron, 2 sulfur cluster binding
Acear_0066	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Acear_0068	COG2340	Cysteine-rich secretory protein family
Acear_0073	COG1115	amino acid carrier protein
Acear_0079	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Acear_0080	COG1376	ErfK ybiS ycfS ynhG family protein
Acear_0081	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Acear_0083	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Acear_0085	COG0789	Transcriptional regulator
Acear_0086	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Acear_0087	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Acear_0088	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Acear_0089	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Acear_0090	COG0193	aminoacyl-tRNA hydrolase activity
Acear_0092	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Acear_0093	COG2002	toxin-antitoxin pair type II binding
Acear_0094	COG2244	polysaccharide biosynthetic process
Acear_0095	COG3956	TIGRFAM MazG family protein
Acear_0096	COG1686	Belongs to the peptidase S11 family
Acear_0097	COG2385	sporulation resulting in formation of a cellular spore
Acear_0101	COG2183	response to ionizing radiation
Acear_0102	COG1098	S1 RNA binding domain
Acear_0103	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Acear_0104	COG0573	inorganic phosphate transmembrane transporter activity
Acear_0105	COG0581	inorganic phosphate transmembrane transporter activity
Acear_0108	COG2208	phosphoserine phosphatase activity
Acear_0109	COG0037	tRNA processing
Acear_0110	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Acear_0110	COG0037	tRNA processing
Acear_0111	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Acear_0112	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Acear_0114	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Acear_0115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Acear_0116	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Acear_0118	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Acear_0119	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Acear_0121	COG5322	oxidoreductase activity
Acear_0121	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Acear_0123	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Acear_0126	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Acear_0129	COG3880	PFAM UvrB UvrC protein
Acear_0130	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Acear_0131	COG0542	response to heat
Acear_0132	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Acear_0133	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Acear_0134	COG1329	Transcriptional regulator
Acear_0135	COG4956	integral membrane protein (PIN domain superfamily)
Acear_0136	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Acear_0139	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Acear_0139	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Acear_0140	COG1045	serine acetyltransferase
Acear_0142	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Acear_0144	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Acear_0145	COG2720	vancomycin resistance protein
Acear_0147	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Acear_0148	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Acear_0149	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Acear_0150	COG0250	Participates in transcription elongation, termination and antitermination
Acear_0151	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Acear_0152	COG0081	regulation of translation
Acear_0153	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Acear_0154	COG0222	ribosome binding
Acear_0155	COG0085	RNA polymerase activity
Acear_0156	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Acear_0157	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Acear_0159	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Acear_0160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Acear_0162	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Acear_0163	COG0088	Forms part of the polypeptide exit tunnel
Acear_0164	COG0089	rRNA binding
Acear_0165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Acear_0166	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Acear_0167	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Acear_0168	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Acear_0169	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Acear_0170	COG0255	Belongs to the universal ribosomal protein uL29 family
Acear_0171	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Acear_0172	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Acear_0173	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Acear_0174	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Acear_0175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Acear_0176	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Acear_0177	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Acear_0178	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Acear_0179	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Acear_0180	COG0200	Binds to the 23S rRNA
Acear_0182	COG0563	adenylate kinase activity
Acear_0184	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Acear_0185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Acear_0186	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Acear_0187	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Acear_0188	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Acear_0190	COG0203	ribosomal protein L17
Acear_0191	COG1122	ATPase activity
Acear_0192	COG1122	ATPase activity
Acear_0193	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Acear_0195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Acear_0196	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Acear_0197	COG0010	Belongs to the arginase family
Acear_0198	COG3885	ferrous iron binding
Acear_0198	COG2078	PFAM AMMECR1 domain protein
Acear_0201	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acear_0203	COG0277	FAD linked oxidase domain protein
Acear_0203	COG0247	lactate metabolic process
Acear_0205	COG0028	Belongs to the TPP enzyme family
Acear_0206	COG0440	acetolactate synthase activity
Acear_0207	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Acear_0208	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Acear_0209	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Acear_0210	COG0066	3-isopropylmalate dehydratase activity
Acear_0211	COG0473	3-isopropylmalate dehydrogenase activity
Acear_0212	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Acear_0213	COG0471	metal ion transport
Acear_0217	COG1482	cell wall glycoprotein biosynthetic process
Acear_0218	COG2385	sporulation resulting in formation of a cellular spore
Acear_0218	COG2385	sporulation resulting in formation of a cellular spore
Acear_0219	COG0613	PHP domain protein
Acear_0221	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Acear_0223	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Acear_0223	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Acear_0225	COG0840	transmembrane signaling receptor activity
Acear_0234	COG4796	Type ii and iii secretion system protein
Acear_0242	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
Acear_0243	COG1040	competence protein
Acear_0250	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Acear_0251	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Acear_0253	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Acear_0257	COG1516	flagellar protein fliS
Acear_0262	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Acear_0264	COG1606	tRNA processing
Acear_0265	COG1691	(AIR) carboxylase
Acear_0268	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Acear_0272	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acear_0275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Acear_0276	COG0653	protein targeting
Acear_0282	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Acear_0283	COG3959	Transketolase, thiamine diphosphate binding domain
Acear_0284	COG3958	Transketolase
Acear_0285	COG0793	Belongs to the peptidase S41A family
Acear_0287	COG0556	nucleotide-excision repair
Acear_0288	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Acear_0289	COG0322	excinuclease ABC activity
Acear_0292	COG1105	Belongs to the carbohydrate kinase PfkB family
Acear_0296	COG1937	Protein conserved in bacteria
Acear_0298	COG0561	phosphatase activity
Acear_0300	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
Acear_0301	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Acear_0302	COG0438	transferase activity, transferring glycosyl groups
Acear_0303	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Acear_0306	COG1940	carbohydrate kinase activity
Acear_0310	COG1543	Belongs to the glycosyl hydrolase 57 family
Acear_0312	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Acear_0317	COG1660	Displays ATPase and GTPase activities
Acear_0318	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Acear_0319	COG1481	regulation of sporulation
Acear_0320	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Acear_0323	COG0126	phosphoglycerate kinase activity
Acear_0324	COG0149	triose-phosphate isomerase activity
Acear_0325	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Acear_0326	COG0148	phosphopyruvate hydratase activity
Acear_0327	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Acear_0328	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Acear_0332	COG0557	exoribonuclease II activity
Acear_0333	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Acear_0340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Acear_0340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Acear_0341	COG0312	modulator of DNA gyrase
Acear_0342	COG0312	modulator of DNA gyrase
Acear_0343	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Acear_0344	COG1971	Probably functions as a manganese efflux pump
Acear_0345	COG0237	dephospho-CoA kinase activity
Acear_0346	COG1803	Methylglyoxal synthase
Acear_0347	COG0741	lytic transglycosylase activity
Acear_0349	COG0709	Synthesizes selenophosphate from selenide and ATP
Acear_0354	COG5012	cobalamin binding
Acear_0357	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Acear_0359	COG1181	Belongs to the D-alanine--D-alanine ligase family
Acear_0361	COG0583	DNA-binding transcription factor activity
Acear_0362	COG4656	Part of a membrane complex involved in electron transport
Acear_0363	COG1805	sodium ion transport
Acear_0365	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Acear_0366	COG4657	Part of a membrane complex involved in electron transport
Acear_0367	COG2871	sodium ion transport
Acear_0370	COG0442	prolyl-tRNA aminoacylation
Acear_0372	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Acear_0373	COG0488	(ABC) transporter
Acear_0374	COG1136	(ABC) transporter
Acear_0374	COG0577	efflux transmembrane transporter activity
Acear_0375	COG0577	efflux transmembrane transporter activity
Acear_0375	COG1136	(ABC) transporter
Acear_0380	COG1773	rubredoxin
Acear_0381	COG0426	domain, Protein
Acear_0383	COG1278	Cold shock
Acear_0384	COG3409	Peptidoglycan-binding domain 1 protein
Acear_0384	COG3773	Cell wall hydrolase
Acear_0385	COG2959	enzyme of heme biosynthesis
Acear_0386	COG0569	domain protein
Acear_0388	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Acear_0389	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Acear_0390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Acear_0391	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Acear_0392	COG0569	domain protein
Acear_0393	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Acear_0394	COG0569	domain protein
Acear_0395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Acear_0397	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Acear_0398	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acear_0398	COG0072	phenylalanine-tRNA ligase activity
Acear_0401	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Acear_0401	COG1796	DNA polymerase
Acear_0403	COG1193	negative regulation of DNA recombination
Acear_0405	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Acear_0406	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Acear_0410	COG0628	permease
Acear_0411	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Acear_0414	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Acear_0417	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Acear_0425	COG1191	sigma factor activity
Acear_0427	COG0791	NLP P60 protein
Acear_0427	COG1388	LysM domain
Acear_0429	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Acear_0430	COG3409	Peptidoglycan-binding domain 1 protein
Acear_0430	COG3773	Cell wall hydrolase
Acear_0432	COG0644	oxidoreductase
Acear_0433	COG2002	toxin-antitoxin pair type II binding
Acear_0434	COG4175	Glycine betaine
Acear_0434	COG3448	diguanylate cyclase activity
Acear_0436	COG2113	Glycine betaine
Acear_0438	COG4176	ABC-type proline glycine betaine transport system permease component
Acear_0439	COG5012	cobalamin binding
Acear_0442	COG5598	trimethylamine methyltransferase
Acear_0443	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Acear_0444	COG5012	cobalamin binding
Acear_0446	COG0840	transmembrane signaling receptor activity
Acear_0450	COG0471	metal ion transport
Acear_0451	COG3426	butyrate kinase activity
Acear_0452	COG0280	phosphate acetyltransferase
Acear_0454	COG0674	pyruvate-flavodoxin oxidoreductase activity
Acear_0454	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Acear_0455	COG1013	pyruvate-flavodoxin oxidoreductase activity
Acear_0458	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Acear_0459	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Acear_0460	COG0167	dihydroorotate dehydrogenase activity
Acear_0464	COG3135	benzoate transporter
Acear_0465	COG3842	ATPase activity
Acear_0467	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Acear_0467	COG3608	succinylglutamate desuccinylase aspartoacylase
Acear_0473	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Acear_0473	COG3608	succinylglutamate desuccinylase aspartoacylase
Acear_0475	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Acear_0479	COG4865	methylaspartate mutase activity
Acear_0483	COG3290	protein histidine kinase activity
Acear_0483	COG3829	transcription factor binding
Acear_0486	COG1757	Na H antiporter
Acear_0487	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Acear_0488	COG1914	H( )-stimulated, divalent metal cation uptake system
Acear_0490	COG4336	lyase activity
Acear_0491	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Acear_0492	COG1984	allophanate hydrolase subunit 2
Acear_0495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Acear_0496	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Acear_0498	COG0544	peptidyl-prolyl cis-trans isomerase activity
Acear_0499	COG0740	serine-type endopeptidase activity
Acear_0500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Acear_0501	COG1067	ATP-dependent peptidase activity
Acear_0501	COG0470	DNA polymerase III
Acear_0502	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Acear_0503	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Acear_0505	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Acear_0506	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Acear_0507	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Acear_0508	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Acear_0509	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Acear_0510	COG0402	S-adenosylhomocysteine deaminase activity
Acear_0511	COG0163	prenyltransferase activity
Acear_0512	COG0525	valine-tRNA ligase activity
Acear_0515	COG1757	Na H antiporter
Acear_0516	COG0252	asparaginase activity
Acear_0517	COG0281	malic enzyme
Acear_0518	COG1027	Aspartate ammonia-lyase
Acear_0519	COG1794	racemase activity, acting on amino acids and derivatives
Acear_0522	COG0372	Belongs to the citrate synthase family
Acear_0528	COG0285	dihydrofolate synthase activity
Acear_0531	COG0516	GMP reductase activity
Acear_0531	COG0517	IMP dehydrogenase activity
Acear_0533	COG4656	Part of a membrane complex involved in electron transport
Acear_0534	COG4658	electron transport chain
Acear_0535	COG4659	FMN binding
Acear_0536	COG4660	Part of a membrane complex involved in electron transport
Acear_0537	COG4657	Part of a membrane complex involved in electron transport
Acear_0538	COG1245	4Fe-4S binding domain
Acear_0538	COG2878	Part of a membrane complex involved in electron transport
Acear_0539	COG2226	methyltransferase
Acear_0540	COG0142	geranyltranstransferase activity
Acear_0541	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Acear_0542	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Acear_0542	COG1648	precorrin-2 dehydrogenase activity
Acear_0543	COG0181	hydroxymethylbilane synthase activity
Acear_0545	COG0113	porphobilinogen synthase activity
Acear_0548	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Acear_0550	COG0746	molybdenum cofactor guanylyltransferase activity
Acear_0552	COG1763	Mo-molybdopterin cofactor biosynthetic process
Acear_0555	COG2003	Belongs to the UPF0758 family
Acear_0556	COG1077	Cell shape determining protein MreB Mrl
Acear_0561	COG2894	cell division
Acear_0562	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Acear_0563	COG0772	Belongs to the SEDS family
Acear_0567	COG1530	ribonuclease E activity
Acear_0568	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Acear_0570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Acear_0571	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Acear_0572	COG1534	Rna-binding protein
Acear_0573	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Acear_0574	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Acear_0577	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Acear_0578	COG1713	HD superfamily hydrolase involved in NAD metabolism
Acear_0580	COG0799	negative regulation of ribosome biogenesis
Acear_0581	COG0495	leucyl-tRNA aminoacylation
Acear_0584	COG4974	Belongs to the 'phage' integrase family
Acear_0585	COG5000	phosphorelay sensor kinase activity
Acear_0596	COG0268	Binds directly to 16S ribosomal RNA
Acear_0598	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Acear_0600	COG0481	GTPase activity
Acear_0601	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Acear_0602	COG1420	regulation of RNA biosynthetic process
Acear_0603	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Acear_0604	COG0443	Heat shock 70 kDa protein
Acear_0605	COG0484	heat shock protein binding
Acear_0606	COG2264	protein methyltransferase activity
Acear_0607	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Acear_0608	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Acear_0609	COG0537	adenosine 5'-monophosphoramidase activity
Acear_0610	COG1610	YqeY-like protein
Acear_0611	COG1030	water channel activity
Acear_0612	COG4864	UPF0365 protein
Acear_0614	COG0659	secondary active sulfate transmembrane transporter activity
Acear_0617	COG1702	phosphate starvation-inducible protein PhoH
Acear_0618	COG1480	7TM receptor with intracellular HD hydrolase
Acear_0619	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Acear_0620	COG1253	flavin adenine dinucleotide binding
Acear_0622	COG0295	cytidine deaminase activity
Acear_0624	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Acear_0625	COG2239	Acts as a magnesium transporter
Acear_0626	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Acear_0631	COG0444	Belongs to the ABC transporter superfamily
Acear_0632	COG4608	Belongs to the ABC transporter superfamily
Acear_0635	COG0243	molybdopterin cofactor binding
Acear_0636	COG0028	Belongs to the TPP enzyme family
Acear_0637	COG0440	acetolactate synthase activity
Acear_0639	COG0095	Lipoate-protein ligase
Acear_0640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Acear_0646	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Acear_0647	COG0513	Belongs to the DEAD box helicase family
Acear_0652	COG0326	Molecular chaperone. Has ATPase activity
Acear_0653	COG3385	transposase activity
Acear_0654	COG1396	sequence-specific DNA binding
Acear_0661	COG0375	protein maturation
Acear_0662	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Acear_0663	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Acear_0668	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Acear_0669	COG1132	(ABC) transporter
Acear_0670	COG1132	(ABC) transporter
Acear_0675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Acear_0675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Acear_0680	COG1381	Involved in DNA repair and RecF pathway recombination
Acear_0682	COG0752	glycyl-tRNA synthetase alpha subunit
Acear_0683	COG0751	glycine-tRNA ligase activity
Acear_0684	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Acear_0685	COG0517	IMP dehydrogenase activity
Acear_0686	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Acear_0687	COG1494	fructose-1,6-bisphosphatase
Acear_0688	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Acear_0688	COG0574	Belongs to the PEP-utilizing enzyme family
Acear_0689	COG0431	NADPH-dependent FMN reductase
Acear_0690	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Acear_0692	COG0358	DNA primase activity
Acear_0693	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Acear_0694	COG2384	SAM-dependent methyltransferase
Acear_0695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Acear_0697	COG0328	RNA-DNA hybrid ribonuclease activity
Acear_0699	COG1605	Chorismate mutase
Acear_0699	COG0077	Prephenate dehydratase
Acear_0700	COG0217	transcriptional regulatory protein
Acear_0702	COG0632	four-way junction helicase activity
Acear_0705	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Acear_0706	COG0343	queuine tRNA-ribosyltransferase activity
Acear_0710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Acear_0711	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Acear_0714	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Acear_0716	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Acear_0716	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Acear_0717	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Acear_0718	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Acear_0719	COG1490	D-aminoacyl-tRNA deacylase activity
Acear_0720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Acear_0722	COG0124	histidyl-tRNA synthetase
Acear_0723	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Acear_0724	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Acear_0725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Acear_0726	COG1739	Uncharacterized protein family UPF0029
Acear_0727	COG2364	Membrane
Acear_0728	COG1959	2 iron, 2 sulfur cluster binding
Acear_0729	COG1104	cysteine desulfurase activity
Acear_0731	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Acear_0731	COG0519	Catalyzes the synthesis of GMP from XMP
Acear_0735	COG2431	L-lysine efflux transmembrane transporter activity
Acear_0737	COG2001	Belongs to the MraZ family
Acear_0738	COG0275	rRNA processing
Acear_0740	COG0768	penicillin binding
Acear_0741	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Acear_0742	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Acear_0743	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Acear_0744	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Acear_0745	COG0772	Belongs to the SEDS family
Acear_0746	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Acear_0747	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Acear_0748	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Acear_0749	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Acear_0750	COG1181	Belongs to the D-alanine--D-alanine ligase family
Acear_0753	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Acear_0755	COG1191	sigma factor activity
Acear_0757	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Acear_0759	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Acear_0766	COG0310	cobalt ion transport
Acear_0768	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Acear_0769	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Acear_0770	COG1120	ATPase activity
Acear_0771	COG4206	TonB-dependent receptor
Acear_0773	COG0811	peptide transport
Acear_0774	COG0848	biopolymer transport protein
Acear_0777	COG0310	cobalt ion transport
Acear_0779	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Acear_0780	COG1122	ATPase activity
Acear_0782	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Acear_0783	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Acear_0784	COG1720	tRNA m6t6A37 methyltransferase activity
Acear_0791	COG0310	cobalt ion transport
Acear_0792	COG0310	cobalt ion transport
Acear_0797	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Acear_0799	COG1929	Belongs to the glycerate kinase type-1 family
Acear_0809	COG0371	Dehydrogenase
Acear_0821	COG1518	maintenance of DNA repeat elements
Acear_0821	COG1468	defense response to virus
Acear_0822	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Acear_0829	COG1640	4-alpha-glucanotransferase
Acear_0831	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Acear_0835	COG2875	Belongs to the precorrin methyltransferase family
Acear_0839	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Acear_0840	COG1492	cobalamin metabolic process
Acear_0841	COG1492	cobalamin metabolic process
Acear_0842	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Acear_0845	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Acear_0847	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Acear_0848	COG0406	alpha-ribazole phosphatase activity
Acear_0850	COG1191	sigma factor activity
Acear_0852	COG1873	PFAM PRC-barrel domain
Acear_0853	COG0864	Transcriptional regulator
Acear_0855	COG0745	RESPONSE REGULATOR receiver
Acear_0856	COG5002	protein histidine kinase activity
Acear_0859	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Acear_0861	COG0745	RESPONSE REGULATOR receiver
Acear_0862	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Acear_0863	COG0573	inorganic phosphate transmembrane transporter activity
Acear_0864	COG0581	inorganic phosphate transmembrane transporter activity
Acear_0865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Acear_0866	COG0704	Plays a role in the regulation of phosphate uptake
Acear_0868	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Acear_0869	COG5002	protein histidine kinase activity
Acear_0870	COG0745	RESPONSE REGULATOR receiver
Acear_0870	COG3706	GGDEF domain
Acear_0873	COG3706	GGDEF domain
Acear_0874	COG1151	hydroxylamine reductase activity
Acear_0876	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Acear_0877	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Acear_0879	COG2302	S4 RNA-binding domain
Acear_0882	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Acear_0883	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Acear_0885	COG0425	Belongs to the sulfur carrier protein TusA family
Acear_0887	COG1104	cysteine desulfurase activity
Acear_0890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Acear_0891	COG0564	pseudouridine synthase activity
Acear_0893	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Acear_0894	COG2233	PERMEase
Acear_0895	COG0540	Belongs to the ATCase OTCase family
Acear_0896	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Acear_0897	COG0284	orotidine-5'-phosphate decarboxylase activity
Acear_0898	COG0505	Belongs to the CarA family
Acear_0899	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Acear_0900	COG0543	2 iron, 2 sulfur cluster binding
Acear_0901	COG0167	dihydroorotate dehydrogenase activity
Acear_0902	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Acear_0910	COG0662	Cupin 2, conserved barrel domain protein
Acear_0915	COG4895	conserved protein (DUF2196)
Acear_0916	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Acear_0920	COG2002	toxin-antitoxin pair type II binding
Acear_0923	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Acear_0927	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Acear_0928	COG5598	trimethylamine methyltransferase
Acear_0929	COG5012	cobalamin binding
Acear_0932	COG0840	transmembrane signaling receptor activity
Acear_0937	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Acear_0949	COG2414	aldehyde ferredoxin oxidoreductase
Acear_0951	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Acear_0952	COG1063	alcohol dehydrogenase
Acear_0953	COG5012	cobalamin binding
Acear_0955	COG0281	malic enzyme
Acear_0959	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Acear_0960	COG0835	chemotaxis
Acear_0961	COG0643	Histidine kinase
Acear_0961	COG2198	Histidine kinase
Acear_0962	COG2201	protein-glutamate methylesterase activity
Acear_0963	COG2201	protein-glutamate methylesterase activity
Acear_0964	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Acear_0967	COG2323	membrane
Acear_0969	COG0187	DNA topoisomerase II activity
Acear_0976	COG0437	4 iron, 4 sulfur cluster binding
Acear_0977	COG2414	aldehyde ferredoxin oxidoreductase
Acear_0981	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Acear_0983	COG1151	hydroxylamine reductase activity
Acear_0984	COG0437	4 iron, 4 sulfur cluster binding
Acear_0991	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Acear_0994	COG2033	superoxide reductase activity
Acear_0995	COG1592	Rubrerythrin
Acear_0998	COG1752	Esterase of the alpha-beta hydrolase superfamily
Acear_0999	COG3480	Lon protease (S16) C-terminal proteolytic domain
Acear_1000	COG1323	Belongs to the UPF0348 family
Acear_1002	COG0280	phosphate acetyltransferase
Acear_1003	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Acear_1006	COG0534	Mate efflux family protein
Acear_1007	COG0280	phosphate acetyltransferase
Acear_1008	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Acear_1010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Acear_1011	COG2030	dehydratase
Acear_1013	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Acear_1015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Acear_1016	COG1028	Short-chain dehydrogenase reductase Sdr
Acear_1017	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Acear_1019	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Acear_1024	COG2081	HI0933 family
Acear_1028	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Acear_1029	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Acear_1031	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Acear_1033	COG0204	Acyl-transferase
Acear_1035	COG3279	Response regulator of the LytR AlgR family
Acear_1036	COG1966	Carbon starvation protein
Acear_1037	COG0539	negative regulation of cytoplasmic translation
Acear_1037	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Acear_1039	COG0860	N-Acetylmuramoyl-L-alanine amidase
Acear_1045	COG1160	GTP binding
Acear_1046	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Acear_1047	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Acear_1048	COG3835	regulator
Acear_1049	COG5598	trimethylamine methyltransferase
Acear_1050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Acear_1051	COG5012	cobalamin binding
Acear_1052	COG5598	trimethylamine methyltransferase
Acear_1053	COG5012	cobalamin binding
Acear_1056	COG1410	methionine synthase
Acear_1056	COG0646	methionine synthase
Acear_1065	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Acear_1068	COG4492	Belongs to the UPF0735 family
Acear_1069	COG0460	homoserine dehydrogenase
Acear_1071	COG0083	homoserine kinase activity
Acear_1072	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Acear_1072	COG0646	methionine synthase
Acear_1075	COG2323	membrane
Acear_1078	COG2094	Belongs to the DNA glycosylase MPG family
Acear_1079	COG1827	regulation of RNA biosynthetic process
Acear_1082	COG0157	Belongs to the NadC ModD family
Acear_1086	COG1543	Belongs to the glycosyl hydrolase 57 family
Acear_1087	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Acear_1088	COG0297	glycogen (starch) synthase activity
Acear_1090	COG1863	multisubunit Na H antiporter MnhE subunit
Acear_1096	COG1006	Multisubunit Na H antiporter MnhC subunit
Acear_1097	COG0651	ATP synthesis coupled electron transport
Acear_1098	COG0651	ATP synthesis coupled electron transport
Acear_1106	COG2217	Heavy metal translocating P-type atpase
Acear_1107	COG1278	Cold shock
Acear_1108	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Acear_1109	COG3404	Formiminotransferase-cyclodeaminase
Acear_1110	COG3409	Peptidoglycan-binding domain 1 protein
Acear_1110	COG3773	Cell wall hydrolase
Acear_1112	COG2002	toxin-antitoxin pair type II binding
Acear_1113	COG0640	Transcriptional regulator
Acear_1115	COG3118	belongs to the thioredoxin family
Acear_1116	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Acear_1118	COG3409	Peptidoglycan-binding domain 1 protein
Acear_1118	COG3773	Cell wall hydrolase
Acear_1120	COG0860	N-Acetylmuramoyl-L-alanine amidase
Acear_1125	COG0438	transferase activity, transferring glycosyl groups
Acear_1128	COG1396	sequence-specific DNA binding
Acear_1129	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Acear_1147	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Acear_1148	COG0709	Synthesizes selenophosphate from selenide and ATP
Acear_1152	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Acear_1154	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Acear_1156	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Acear_1157	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Acear_1158	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Acear_1159	COG0464	growth
Acear_1160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Acear_1167	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Acear_1169	COG2244	polysaccharide biosynthetic process
Acear_1170	COG4974	Belongs to the 'phage' integrase family
Acear_1171	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Acear_1173	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Acear_1174	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Acear_1175	COG1757	Na H antiporter
Acear_1181	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Acear_1184	COG3859	Proton-coupled thiamine transporter YuaJ
Acear_1188	COG0514	ATP-dependent DNA helicase (RecQ)
Acear_1193	COG0251	oxidation-reduction process
Acear_1194	COG2964	Protein conserved in bacteria
Acear_1196	COG1760	l-serine dehydratase
Acear_1197	COG1760	l-serine dehydratase
Acear_1198	COG2197	response regulator
Acear_1200	COG3875	lactate racemase activity
Acear_1211	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Acear_1217	COG2323	membrane
Acear_1219	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Acear_1221	COG5012	cobalamin binding
Acear_1222	COG5598	trimethylamine methyltransferase
Acear_1224	COG1309	transcriptional regulator
Acear_1226	COG2340	Cysteine-rich secretory protein family
Acear_1228	COG1388	LysM domain
Acear_1228	COG0791	NLP P60 protein
Acear_1234	COG1051	belongs to the nudix hydrolase family
Acear_1240	COG0328	RNA-DNA hybrid ribonuclease activity
Acear_1242	COG0826	peptidase U32
Acear_1248	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Acear_1253	COG3976	FMN-binding domain protein
Acear_1253	COG1053	succinate dehydrogenase
Acear_1255	COG0326	Molecular chaperone. Has ATPase activity
Acear_1257	COG1378	Sugar-specific transcriptional regulator TrmB
Acear_1261	COG3344	reverse transcriptase
Acear_1265	COG5002	protein histidine kinase activity
Acear_1266	COG1067	ATP-dependent peptidase activity
Acear_1267	COG0739	heme binding
Acear_1268	COG0726	polysaccharide deacetylase
Acear_1272	COG5012	cobalamin binding
Acear_1274	COG1525	nuclease
Acear_1279	COG0456	acetyltransferase
Acear_1280	COG1509	lysine 2,3-aminomutase activity
Acear_1284	COG0301	tRNA thio-modification
Acear_1285	COG1104	cysteine desulfurase activity
Acear_1286	COG0011	TIGRFAM Protein of
Acear_1288	COG0733	neurotransmitter:sodium symporter activity
Acear_1290	COG1533	DNA photolyase activity
Acear_1294	COG1363	Peptidase, m42
Acear_1298	COG1615	UPF0182 protein
Acear_1305	COG1151	hydroxylamine reductase activity
Acear_1308	COG3706	GGDEF domain
Acear_1308	COG4251	negative regulation of phosphorylation
Acear_1308	COG2203	Gaf domain
Acear_1308	COG5001	Diguanylate cyclase
Acear_1316	COG0028	Belongs to the TPP enzyme family
Acear_1317	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Acear_1318	COG1116	anion transmembrane transporter activity
Acear_1319	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Acear_1322	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Acear_1323	COG1331	Highly conserved protein containing a thioredoxin domain
Acear_1327	COG0622	Phosphoesterase
Acear_1329	COG0583	DNA-binding transcription factor activity
Acear_1331	COG2201	protein-glutamate methylesterase activity
Acear_1332	COG1573	uracil-dna glycosylase
Acear_1335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Acear_1337	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Acear_1339	COG2814	Major facilitator Superfamily
Acear_1341	COG2707	UPF0756 membrane protein
Acear_1342	COG2045	Belongs to the ComB family
Acear_1343	COG1809	phosphosulfolactate synthase activity
Acear_1345	COG1397	ADP-ribosylglycohydrolase
Acear_1346	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Acear_1347	COG3842	ATPase activity
Acear_1348	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Acear_1349	COG0725	ABC transporter, periplasmic molybdate-binding protein
Acear_1351	COG3585	molybdate ion transport
Acear_1353	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Acear_1355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Acear_1356	COG0569	domain protein
Acear_1364	COG2323	membrane
Acear_1366	COG1131	(ABC) transporter
Acear_1367	COG0842	Transport permease protein
Acear_1370	COG0569	domain protein
Acear_1370	COG0475	glutathione-regulated potassium exporter activity
Acear_1371	COG0569	domain protein
Acear_1372	COG2204	response regulator
Acear_1373	COG0745	RESPONSE REGULATOR receiver
Acear_1374	COG5002	protein histidine kinase activity
Acear_1385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Acear_1391	COG1404	Belongs to the peptidase S8 family
Acear_1392	COG0464	growth
Acear_1395	COG1473	amidohydrolase
Acear_1396	COG4145	pantothenate transmembrane transporter activity
Acear_1400	COG0484	heat shock protein binding
Acear_1402	COG3314	Sporulation integral membrane protein YlbJ
Acear_1405	COG3264	Mechanosensitive ion channel
Acear_1405	COG1511	domain protein
Acear_1406	COG2364	Membrane
Acear_1408	COG0628	permease
Acear_1409	COG0602	queuosine metabolic process
Acear_1410	COG0720	synthase
Acear_1412	COG1924	4 iron, 4 sulfur cluster binding
Acear_1417	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Acear_1418	COG0742	ribosomal rna small subunit methyltransferase
Acear_1419	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Acear_1420	COG1307	EDD domain protein, DegV family
Acear_1421	COG1461	Dihydroxyacetone kinase
Acear_1422	COG1302	Protein conserved in bacteria
Acear_1424	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Acear_1425	COG0281	malic enzyme
Acear_1427	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Acear_1428	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Acear_1429	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Acear_1429	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Acear_1431	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Acear_1431	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Acear_1432	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Acear_1433	COG1162	GTPase activity
Acear_1434	COG0515	serine threonine protein kinase
Acear_1434	COG2815	serine threonine protein kinase
Acear_1435	COG0631	protein serine/threonine phosphatase activity
Acear_1436	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Acear_1437	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Acear_1437	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Acear_1439	COG2738	Putative neutral zinc metallopeptidase
Acear_1442	COG0242	peptide deformylase activity
Acear_1443	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Acear_1444	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Acear_1446	COG4120	Belongs to the binding-protein-dependent transport system permease family
Acear_1448	COG1854	S-ribosylhomocysteine lyase activity
Acear_1449	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Acear_1450	COG1758	RNA polymerase activity
Acear_1451	COG0194	GDP metabolic process
Acear_1453	COG1561	YicC-like family, N-terminal region
Acear_1455	COG0107	imidazoleglycerol-phosphate synthase activity
Acear_1456	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Acear_1457	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Acear_1459	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Acear_1460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Acear_1461	COG0124	histidyl-tRNA synthetase
Acear_1462	COG3773	Cell wall hydrolase
Acear_1463	COG0105	UTP biosynthetic process
Acear_1464	COG1196	nuclear chromosome segregation
Acear_1467	COG0848	biopolymer transport protein
Acear_1468	COG0811	peptide transport
Acear_1469	COG0587	DNA-directed DNA polymerase activity
Acear_1470	COG0700	Nucleoside recognition
Acear_1471	COG2715	membrane protein required for spore maturation
Acear_1472	COG2359	stage V sporulation protein S
Acear_1473	COG1692	metallophosphoesterase
Acear_1474	COG1418	mRNA catabolic process
Acear_1479	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Acear_1482	COG1546	Belongs to the CinA family
Acear_1482	COG1058	Belongs to the CinA family
Acear_1484	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Acear_1487	COG2414	aldehyde ferredoxin oxidoreductase
Acear_1494	COG0371	Dehydrogenase
Acear_1495	COG0436	Aminotransferase
Acear_1497	COG0517	IMP dehydrogenase activity
Acear_1499	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Acear_1500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acear_1504	COG1597	lipid kinase activity
Acear_1507	COG0612	Peptidase, M16
Acear_1517	COG2414	aldehyde ferredoxin oxidoreductase
Acear_1519	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Acear_1521	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Acear_1522	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Acear_1525	COG0302	gtp cyclohydrolase
Acear_1530	COG0165	Argininosuccinate lyase
Acear_1532	COG0137	argininosuccinate synthase activity
Acear_1533	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Acear_1534	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Acear_1535	COG0505	Belongs to the CarA family
Acear_1538	COG2323	membrane
Acear_1541	COG1121	(ABC) transporter
Acear_1542	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Acear_1543	COG0697	spore germination
Acear_1544	COG0531	amino acid
Acear_1545	COG0531	amino acid
Acear_1549	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Acear_1550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Acear_1551	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Acear_1552	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Acear_1553	COG1278	Cold shock
Acear_1555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Acear_1557	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Acear_1559	COG1426	Protein conserved in bacteria
Acear_1560	COG1968	undecaprenyl-diphosphatase activity
Acear_1561	COG3331	DNA recombination
Acear_1562	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Acear_1563	COG2155	Conserved Protein
Acear_1564	COG1388	LysM domain
Acear_1564	COG3584	3D domain protein
Acear_1565	COG1674	ftsk spoiiie
Acear_1566	COG1283	sodium-dependent phosphate transmembrane transporter activity
Acear_1567	COG1283	sodium-dependent phosphate transmembrane transporter activity
Acear_1569	COG0740	serine-type endopeptidase activity
Acear_1571	COG2022	thiamine diphosphate biosynthetic process
Acear_1572	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Acear_1573	COG0352	thiamine-phosphate diphosphorylase activity
Acear_1574	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Acear_1575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Acear_1576	COG0527	aspartate kinase activity
Acear_1577	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Acear_1578	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Acear_1579	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Acear_1580	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Acear_1582	COG1873	PFAM PRC-barrel domain
Acear_1583	COG0756	dUTP diphosphatase activity
Acear_1584	COG2720	vancomycin resistance protein
Acear_1585	COG0726	polysaccharide deacetylase
Acear_1586	COG0726	polysaccharide deacetylase
Acear_1587	COG0860	N-Acetylmuramoyl-L-alanine amidase
Acear_1588	COG3409	Peptidoglycan-binding domain 1 protein
Acear_1588	COG3773	Cell wall hydrolase
Acear_1589	COG1199	ATP-dependent helicase activity
Acear_1590	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Acear_1591	COG1185	polyribonucleotide nucleotidyltransferase activity
Acear_1592	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Acear_1593	COG0196	riboflavin kinase activity
Acear_1594	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Acear_1595	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Acear_1596	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Acear_1597	COG0195	Participates in both transcription termination and antitermination
Acear_1600	COG1285	pathogenesis
Acear_1602	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Acear_1603	COG1418	mRNA catabolic process
Acear_1604	COG0750	zinc metalloprotease
Acear_1605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Acear_1607	COG4589	Belongs to the CDS family
Acear_1609	COG0233	cytoplasmic translational termination
Acear_1610	COG0528	UMP kinase activity
Acear_1611	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Acear_1612	COG0052	Belongs to the universal ribosomal protein uS2 family
Acear_1617	COG1191	sigma factor activity
Acear_1619	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Acear_1620	COG1776	CheC inhibitor of MCP methylation
Acear_1622	COG0455	bacterial-type flagellum organization
Acear_1623	COG1419	protein localization to endoplasmic reticulum
Acear_1624	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Acear_1625	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Acear_1626	COG1684	flagellar biosynthetic protein fliR
Acear_1627	COG1987	bacterial-type flagellum assembly
Acear_1628	COG1338	Plays a role in the flagellum-specific transport system
Acear_1631	COG1776	CheC inhibitor of MCP methylation
Acear_1631	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Acear_1632	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Acear_1634	COG1360	Flagellar Motor Protein
Acear_1639	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Acear_1640	COG3144	bacterial-type flagellum assembly
Acear_1643	COG1157	protein secretion by the type III secretion system
Acear_1645	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Acear_1646	COG1766	The M ring may be actively involved in energy transduction
Acear_1647	COG1677	Flagellar hook-basal body complex protein FliE
Acear_1649	COG1815	bacterial-type flagellum-dependent cell motility
Acear_1651	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Acear_1652	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Acear_1653	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Acear_1655	COG0758	DNA mediated transformation
Acear_1655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Acear_1656	COG0606	chelatase, subunit chli
Acear_1657	COG0792	nuclease activity
Acear_1659	COG0393	Putative heavy-metal-binding
Acear_1662	COG0681	Belongs to the peptidase S26 family
Acear_1663	COG0335	large ribosomal subunit rRNA binding
Acear_1664	COG4752	Belongs to the RNA methyltransferase TrmD family
Acear_1665	COG0336	Belongs to the RNA methyltransferase TrmD family
Acear_1666	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Acear_1668	COG0228	four-way junction DNA binding
Acear_1669	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Acear_1670	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Acear_1671	COG0552	protein localization to endoplasmic reticulum
Acear_1673	COG1196	nuclear chromosome segregation
Acear_1674	COG2359	stage V sporulation protein S
Acear_1676	COG1187	pseudouridine synthase activity
Acear_1677	COG1686	Belongs to the peptidase S11 family
Acear_1678	COG3874	Sporulation protein YtfJ
Acear_1680	COG2221	Nitrite and sulphite reductase 4Fe-4S
Acear_1683	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Acear_1684	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Acear_1685	COG0180	Tryptophanyl-tRNA synthetase
Acear_1686	COG1994	Peptidase M50
Acear_1687	COG0617	tRNA 3'-terminal CCA addition
Acear_1688	COG0019	diaminopimelate decarboxylase activity
Acear_1689	COG1254	Belongs to the acylphosphatase family
Acear_1691	COG1309	transcriptional regulator
Acear_1693	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Acear_1694	COG2409	Drug exporters of the RND superfamily
Acear_1699	COG0697	spore germination
Acear_1702	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Acear_1706	COG2172	sigma factor antagonist activity
Acear_1708	COG1686	Belongs to the peptidase S11 family
Acear_1709	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Acear_1711	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Acear_1712	COG1300	Membrane
Acear_1716	COG2195	Cleaves the N-terminal amino acid of tripeptides
Acear_1717	COG3457	Alanine racemase
Acear_1718	COG5012	cobalamin binding
Acear_1721	COG0733	neurotransmitter:sodium symporter activity
Acear_1726	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Acear_1727	COG0745	RESPONSE REGULATOR receiver
Acear_1728	COG0750	zinc metalloprotease
Acear_1729	COG0497	DNA recombination
Acear_1730	COG1438	arginine binding
Acear_1731	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Acear_1732	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Acear_1733	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Acear_1735	COG1722	exodeoxyribonuclease VII activity
Acear_1736	COG1570	exodeoxyribonuclease VII activity
Acear_1737	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Acear_1738	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Acear_1739	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Acear_1742	COG1302	Protein conserved in bacteria
Acear_1743	COG0439	Biotin carboxylase
Acear_1752	COG3854	ATPases associated with a variety of cellular activities
Acear_1753	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Acear_1754	COG0006	proline dipeptidase activity
Acear_1756	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Acear_1757	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Acear_1758	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Acear_1763	COG0849	cell division
Acear_1768	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Acear_1774	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Acear_1775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Acear_1777	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Acear_1779	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Acear_1779	COG1918	ferrous iron import across plasma membrane
Acear_1780	COG0735	belongs to the Fur family
Acear_1781	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Acear_1783	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Acear_1784	COG1418	mRNA catabolic process
Acear_1787	COG0492	ferredoxin-NADP+ reductase activity
Acear_1788	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Acear_1790	COG1342	Belongs to the UPF0251 family
Acear_1792	COG0489	protein tyrosine kinase activity
Acear_1797	COG0735	belongs to the Fur family
Acear_1798	COG2186	Transcriptional regulator
Acear_1799	COG3875	lactate racemase activity
Acear_1800	COG0247	lactate metabolic process
Acear_1801	COG0277	FAD linked oxidase domain protein
Acear_1802	COG1620	l-lactate permease
Acear_1803	COG2186	Transcriptional regulator
Acear_1804	COG0277	FAD linked oxidase domain protein
Acear_1805	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Acear_1808	COG0860	N-Acetylmuramoyl-L-alanine amidase
Acear_1808	COG2247	cell wall binding repeat
Acear_1813	COG0516	GMP reductase activity
Acear_1813	COG0517	IMP dehydrogenase activity
Acear_1815	COG1388	LysM domain
Acear_1815	COG0791	NLP P60 protein
Acear_1816	COG0166	Belongs to the GPI family
Acear_1821	COG0123	including yeast histone deacetylase and acetoin utilization protein
Acear_1826	COG0493	'glutamate synthase
Acear_1826	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Acear_1827	COG0069	glutamate synthase activity
Acear_1828	COG0067	glutamate synthase
Acear_1829	COG0347	Belongs to the P(II) protein family
Acear_1830	COG0004	ammonium transporteR
Acear_1832	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Acear_1834	COG0367	asparagine synthase
Acear_1835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Acear_1837	COG3290	protein histidine kinase activity
Acear_1837	COG3829	transcription factor binding
Acear_1838	COG2031	fatty acid transporter
Acear_1839	COG0183	Belongs to the thiolase family
Acear_1841	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Acear_1843	COG0534	Mate efflux family protein
Acear_1845	COG1388	LysM domain
Acear_1850	COG0534	Mate efflux family protein
Acear_1852	COG1566	PFAM secretion protein HlyD family protein
Acear_1854	COG1309	transcriptional regulator
Acear_1855	COG5598	trimethylamine methyltransferase
Acear_1858	COG0436	Aminotransferase
Acear_1859	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Acear_1861	COG0205	6-phosphofructokinase activity
Acear_1862	COG0825	malonyl-CoA metabolic process
Acear_1863	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Acear_1865	COG0159	tryptophan synthase activity
Acear_1866	COG0133	tryptophan synthase activity
Acear_1868	COG0134	indole-3-glycerol-phosphate synthase activity
Acear_1871	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Acear_1874	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Acear_1880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Acear_1881	COG0432	Pfam Uncharacterised protein family UPF0047
Acear_1882	COG1584	GPR1 FUN34 yaaH family protein
Acear_1885	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Acear_1886	COG0735	belongs to the Fur family
Acear_1887	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Acear_1888	COG0318	PFAM AMP-dependent synthetase and ligase
Acear_1889	COG2032	superoxide dismutase activity
Acear_1891	COG1278	Cold shock
Acear_1892	COG1278	Cold shock
Acear_1894	COG0674	pyruvate-flavodoxin oxidoreductase activity
Acear_1899	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Acear_1900	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Acear_1901	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Acear_1902	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Acear_1903	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Acear_1904	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Acear_1906	COG1192	Involved in chromosome partitioning
Acear_1910	COG5002	protein histidine kinase activity
Acear_1914	COG5002	protein histidine kinase activity
Acear_1915	COG0745	RESPONSE REGULATOR receiver
Acear_1916	COG0577	efflux transmembrane transporter activity
Acear_1916	COG1136	(ABC) transporter
Acear_1917	COG1136	(ABC) transporter
Acear_1922	COG0534	Mate efflux family protein
Acear_1924	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Acear_1925	COG2610	gluconate transmembrane transporter activity
Acear_1927	COG3385	transposase activity
Acear_1932	COG2199	diguanylate cyclase activity
Acear_1932	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Acear_1935	COG2986	histidine ammonia-lyase
Acear_1936	COG1288	antiporter activity
Acear_1937	COG1672	PFAM Archaeal ATPase
Acear_1937	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Acear_1941	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Acear_1947	COG0697	spore germination
Acear_1951	COG0175	sulfate reduction
Acear_1952	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Acear_1954	COG2217	Heavy metal translocating P-type atpase
Acear_1956	COG0785	Cytochrome C biogenesis protein
Acear_1960	COG0482	sulfurtransferase activity
Acear_1961	COG1959	2 iron, 2 sulfur cluster binding
Acear_1962	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Acear_1963	COG1012	belongs to the aldehyde dehydrogenase family
Acear_1963	COG1454	alcohol dehydrogenase
Acear_1966	COG0644	oxidoreductase
Acear_1976	COG0668	transmembrane transport
Acear_1977	COG0789	Transcriptional regulator
Acear_1982	COG2703	oxygen carrier activity
Acear_1983	COG1278	Cold shock
Acear_1985	COG1404	Belongs to the peptidase S8 family
Acear_1990	COG0069	glutamate synthase activity
Acear_1990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Acear_1996	COG5002	protein histidine kinase activity
Acear_1996	COG5001	Diguanylate cyclase
Acear_1996	COG3447	MASE1 domain protein
Acear_2001	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Acear_2009	COG1063	alcohol dehydrogenase
Acear_2012	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Acear_2016	COG2201	protein-glutamate methylesterase activity
Acear_2017	COG0719	Fe-S assembly protein
Acear_2018	COG1137	ATPase activity
Acear_2021	COG0640	Transcriptional regulator
Acear_2027	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Acear_2028	COG0640	Transcriptional regulator
Acear_2029	COG0798	PFAM Bile acid sodium symporter
Acear_2037	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Acear_2045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Acear_2046	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Acear_2047	COG0352	thiamine-phosphate diphosphorylase activity
Acear_2048	COG0352	thiamine-phosphate diphosphorylase activity
Acear_2048	COG0351	phosphomethylpyrimidine kinase
Acear_2049	COG1049	propionate catabolic process, 2-methylcitrate cycle
Acear_2050	COG0446	pyridine nucleotide-disulphide oxidoreductase
Acear_2052	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Acear_2053	COG0473	3-isopropylmalate dehydrogenase activity
Acear_2054	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Acear_2055	COG0154	amidase activity
Acear_2056	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Acear_2057	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Acear_2060	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Acear_2061	COG2339	peptidase activity
Acear_2063	COG0529	Catalyzes the synthesis of activated sulfate
Acear_2064	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Acear_2065	COG1464	Belongs to the NlpA lipoprotein family
Acear_2066	COG2011	ABC-type metal ion transport system permease component
Acear_2067	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Acear_2069	COG4496	protein, YerC YecD
Acear_2070	COG0521	Mo-molybdopterin cofactor biosynthetic process
Acear_2072	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Acear_2073	COG0303	'Molybdopterin
Acear_2074	COG0303	'Molybdopterin
Acear_2076	COG2252	PERMEase
Acear_2082	COG0697	spore germination
Acear_2083	COG0459	protein refolding
Acear_2084	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Acear_2085	COG3830	Belongs to the UPF0237 family
Acear_2086	COG2848	UPF0210 protein
Acear_2088	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Acear_2090	COG1214	PFAM Peptidase M22, glycoprotease
Acear_2091	COG0802	atpase or kinase
Acear_2094	COG1473	amidohydrolase
Acear_2095	COG2337	Toxic component of a toxin-antitoxin (TA) module
Acear_2099	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
Acear_2100	COG0517	IMP dehydrogenase activity
Acear_2101	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Acear_2101	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Acear_2102	COG0736	holo-[acyl-carrier-protein] synthase activity
Acear_2105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Acear_2106	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Acear_2107	COG0179	Fumarylacetoacetate (FAA) hydrolase
Acear_2108	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Acear_2110	COG1396	sequence-specific DNA binding
Acear_2112	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Acear_2113	COG0110	maltose O-acetyltransferase activity
Acear_2114	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Acear_2124	COG1216	Glycosyl transferase, family 2
Acear_2124	COG0463	Glycosyl transferase, family 2
Acear_2132	COG0529	Catalyzes the synthesis of activated sulfate
Acear_2132	COG2895	sulfate adenylyltransferase (ATP) activity
Acear_2135	COG0175	sulfate reduction
Acear_2136	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Acear_2137	COG4464	protein tyrosine phosphatase activity
Acear_2138	COG0489	protein tyrosine kinase activity
Acear_2139	COG3944	biosynthesis protein
Acear_2140	COG1596	polysaccharide export
Acear_2140	COG1555	photosystem II stabilization
Acear_2142	COG1482	cell wall glycoprotein biosynthetic process
Acear_2143	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Acear_2145	COG0463	Glycosyl transferase, family 2
Acear_2156	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Acear_2157	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Acear_2158	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Acear_2159	COG0438	transferase activity, transferring glycosyl groups
Acear_2161	COG0438	transferase activity, transferring glycosyl groups
Acear_2168	COG0859	PFAM glycosyl transferase family 9
Acear_2169	COG0859	PFAM glycosyl transferase family 9
Acear_2170	COG1519	Transferase
Acear_2174	COG3206	protein involved in exopolysaccharide biosynthesis
Acear_2176	COG4372	Transposase
Acear_2178	COG1137	ATPase activity
Acear_2182	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Acear_2184	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Acear_2186	COG1663	tetraacyldisaccharide 4'-kinase activity
Acear_2188	COG1132	(ABC) transporter
Acear_2189	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Acear_2191	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Acear_2192	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Acear_2193	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Acear_2197	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Acear_2205	COG1706	bacterial-type flagellum-dependent cell motility
Acear_2206	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Acear_2209	COG4786	Flagellar basal body rod
Acear_2210	COG1609	Transcriptional regulator
Acear_2212	COG2385	sporulation resulting in formation of a cellular spore
Acear_2213	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Acear_2214	COG5506	Protein of unknown function (DUF1694)
Acear_2215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Acear_2216	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Acear_2217	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Acear_2218	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Acear_2219	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Acear_2220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Acear_2226	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Acear_2227	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Acear_2229	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Acear_2230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Acear_2231	COG0698	ribose 5-phosphate isomerase
Acear_2232	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Acear_2233	COG0009	L-threonylcarbamoyladenylate synthase
Acear_2234	COG2890	protein-(glutamine-N5) methyltransferase activity
Acear_2235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Acear_2236	COG3872	metal-dependent enzyme
Acear_2237	COG0254	rRNA binding
Acear_2238	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Acear_2239	COG0191	fructose-bisphosphate aldolase activity
Acear_2242	COG0504	CTP synthase activity
Acear_2243	COG0018	arginyl-trna synthetase
Acear_2245	COG2707	UPF0756 membrane protein
Acear_2251	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Acear_2253	COG2207	Transcriptional regulator
Acear_2253	COG4753	response regulator
Acear_2254	COG3275	phosphorelay sensor kinase activity
Acear_2256	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Acear_2257	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Acear_2258	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Acear_2259	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Acear_2260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Acear_2264	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Acear_2265	COG0530	calcium, potassium:sodium antiporter activity
Acear_2266	COG1309	transcriptional regulator
Acear_2272	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Acear_2277	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Acear_2282	COG1921	L-seryl-tRNASec selenium transferase activity
Acear_2284	COG1924	4 iron, 4 sulfur cluster binding
Acear_2285	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Acear_2286	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Acear_2287	COG1126	abc transporter atp-binding protein
Acear_2290	COG2897	thiosulfate sulfurtransferase activity
Acear_2296	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Acear_2298	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Acear_2300	COG1034	ATP synthesis coupled electron transport
Acear_2305	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Acear_2308	COG0512	Glutamine amidotransferase of anthranilate synthase
Acear_2311	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Acear_2312	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Acear_2313	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Acear_2315	COG0047	phosphoribosylformylglycinamidine synthase activity
Acear_2316	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Acear_2317	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Acear_2318	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Acear_2319	COG1752	Esterase of the alpha-beta hydrolase superfamily
Acear_2320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Acear_2321	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Acear_2322	COG0151	Belongs to the GarS family
Acear_2323	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Acear_2324	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Acear_2325	COG0305	Participates in initiation and elongation during chromosome replication
Acear_2327	COG0359	binds to the 23S rRNA
Acear_2328	COG4241	membrane
Acear_2331	COG0629	single-stranded DNA binding
Acear_2332	COG0360	Binds together with S18 to 16S ribosomal RNA
Acear_2333	COG0012	GTP binding
Acear_2334	COG4481	Protein conserved in bacteria
Acear_2335	COG3949	Membrane
Acear_2338	COG1811	Na channel or pump
Acear_2339	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Acear_2340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Acear_2342	COG1475	DNA binding
Acear_2343	COG1192	Involved in chromosome partitioning
Acear_2344	COG1475	DNA binding
Acear_2346	COG0357	Ribosomal RNA small subunit methyltransferase G
Acear_2347	COG0445	tRNA wobble uridine modification
Acear_2348	COG0445	tRNA wobble uridine modification
Acear_2349	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Acear_2350	COG1847	R3H domain protein
Acear_2351	COG0706	membrane insertase activity
Acear_2352	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Acear_2353	COG0594	ribonuclease P activity