locus-tag	class	description
BN85400010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BN85400020	COG0592	DNA-directed DNA polymerase activity
BN85400050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BN85400060	COG0187	DNA topoisomerase II activity
BN85400070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BN85400220	COG0534	Mate efflux family protein
BN85400420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BN85400460	COG1136	(ABC) transporter
BN85400460	COG0577	efflux transmembrane transporter activity
BN85400500	COG1733	regulation of RNA biosynthetic process
BN85400510	COG1373	ATPase (AAA superfamily
BN85400530	COG0431	NADPH-dependent FMN reductase
BN85400540	COG0656	L-ascorbic acid biosynthetic process
BN85400580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BN85400590	COG2011	ABC-type metal ion transport system permease component
BN85400600	COG1464	Belongs to the NlpA lipoprotein family
BN85400610	COG3340	Belongs to the peptidase S51 family
BN85400620	COG1136	(ABC) transporter
BN85400630	COG1136	(ABC) transporter
BN85400630	COG0577	efflux transmembrane transporter activity
BN85400660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BN85400670	COG0494	nUDIX hydrolase
BN85400690	COG0537	adenosine 5'-monophosphoramidase activity
BN85400700	COG4869	propanediol catabolic process
BN85400930	COG1078	dGTPase activity
BN85400940	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BN85400950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BN85400960	COG2088	sporulation resulting in formation of a cellular spore
BN85400970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BN85400980	COG0193	aminoacyl-tRNA hydrolase activity
BN85400990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BN85401000	COG1448	Aminotransferase
BN85401040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BN85401050	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BN85401100	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BN85401110	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BN85401130	COG1307	EDD domain protein, DegV family
BN85401160	COG1098	S1 RNA binding domain
BN85401170	COG0166	Belongs to the GPI family
BN85401180	COG0802	atpase or kinase
BN85401200	COG0456	acetyltransferase
BN85401210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BN85401240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BN85401310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BN85401320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BN85401340	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BN85401350	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BN85401360	COG0492	ferredoxin-NADP+ reductase activity
BN85401380	COG0736	holo-[acyl-carrier-protein] synthase activity
BN85401400	COG2183	response to ionizing radiation
BN85401470	COG1982	Orn Lys Arg decarboxylase major
BN85401480	COG0010	Belongs to the arginase family
BN85401500	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BN85401590	COG1609	Transcriptional regulator
BN85401610	COG0095	Lipoate-protein ligase
BN85401620	COG1597	lipid kinase activity
BN85401690	COG0581	inorganic phosphate transmembrane transporter activity
BN85401700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BN85401710	COG0704	Plays a role in the regulation of phosphate uptake
BN85401720	COG0745	RESPONSE REGULATOR receiver
BN85401730	COG5002	protein histidine kinase activity
BN85401740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BN85401740	COG1328	CTP reductase activity
BN85401760	COG1780	Probably involved in ribonucleotide reductase function
BN85401770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BN85401780	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BN85401820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BN85401850	COG2801	Transposase and inactivated derivatives
BN85401930	COG4974	Belongs to the 'phage' integrase family
BN85402090	COG1454	alcohol dehydrogenase
BN85402110	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BN85402190	COG0601	transmembrane transport
BN85402200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BN85402210	COG0444	Belongs to the ABC transporter superfamily
BN85402220	COG4608	Belongs to the ABC transporter superfamily
BN85402240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BN85402250	COG0396	ATPase activity
BN85402260	COG0719	Fe-S assembly protein
BN85402270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BN85402280	COG0822	iron-sulfur transferase activity
BN85402310	COG2508	Transcriptional regulator
BN85402320	COG3842	ATPase activity
BN85402340	COG0126	phosphoglycerate kinase activity
BN85402370	COG0149	triose-phosphate isomerase activity
BN85402390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BN85402400	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BN85402410	COG1956	GAF domain-containing protein
BN85402420	COG0301	tRNA thio-modification
BN85402430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BN85402450	COG0242	peptide deformylase activity
BN85402500	COG0228	four-way junction DNA binding
BN85402510	COG1837	Belongs to the UPF0109 family
BN85402520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BN85402530	COG0336	Belongs to the RNA methyltransferase TrmD family
BN85402540	COG0335	large ribosomal subunit rRNA binding
BN85402560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BN85402600	COG0686	Belongs to the AlaDH PNT family
BN85402620	COG0180	Tryptophanyl-tRNA synthetase
BN85402630	COG1164	Oligoendopeptidase f
BN85402640	COG1393	Belongs to the ArsC family
BN85402680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BN85402700	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BN85402710	COG4974	Belongs to the 'phage' integrase family
BN85402720	COG0756	dUTP diphosphatase activity
BN85402730	COG0052	Belongs to the universal ribosomal protein uS2 family
BN85402740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BN85402750	COG0528	UMP kinase activity
BN85402760	COG0233	cytoplasmic translational termination
BN85402770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BN85402780	COG4589	Belongs to the CDS family
BN85402810	COG0572	uridine kinase
BN85402820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BN85402880	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BN85403010	COG0542	response to heat
BN85403070	COG2610	gluconate transmembrane transporter activity
BN85403080	COG1929	Belongs to the glycerate kinase type-1 family
BN85403110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BN85403150	COG0732	type I restriction modification DNA specificity domain
BN85403160	COG0582	viral genome integration into host DNA
BN85403280	COG1694	Mazg nucleotide pyrophosphohydrolase
BN85403290	COG1611	Belongs to the LOG family
BN85403330	COG0501	Belongs to the peptidase M48B family
BN85403350	COG0488	(ABC) transporter
BN85403370	COG1827	regulation of RNA biosynthetic process
BN85403460	COG0194	GDP metabolic process
BN85403470	COG0450	alkyl hydroperoxide reductase
BN85403560	COG1131	(ABC) transporter
BN85403580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BN85403600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BN85403610	COG1959	2 iron, 2 sulfur cluster binding
BN85403630	COG1132	(ABC) transporter
BN85403690	COG1346	cytolysis
BN85403710	COG1132	(ABC) transporter
BN85403720	COG1902	pentaerythritol trinitrate reductase activity
BN85403760	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BN85403780	COG1609	Transcriptional regulator
BN85403800	COG1312	Catalyzes the dehydration of D-mannonate
BN85403810	COG0246	Mannitol dehydrogenase
BN85403900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BN85403910	COG1126	abc transporter atp-binding protein
BN85403920	COG0765	amino acid transport
BN85403940	COG0038	chloride channel
BN85403950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BN85403970	COG0495	leucyl-tRNA aminoacylation
BN85403980	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BN85403990	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BN85404000	COG1242	4 iron, 4 sulfur cluster binding
BN85404020	COG2176	DNA-directed DNA polymerase activity
BN85404040	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BN85404050	COG0072	phenylalanine-tRNA ligase activity
BN85404050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BN85404060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BN85404070	COG1162	GTPase activity
BN85404080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BN85404100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BN85404110	COG1461	Dihydroxyacetone kinase
BN85404130	COG1132	(ABC) transporter
BN85404140	COG3557	Belongs to the UPF0374 family
BN85404170	COG0519	Catalyzes the synthesis of GMP from XMP
BN85404190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BN85404200	COG0765	amino acid transport
BN85404210	COG1126	abc transporter atp-binding protein
BN85404230	COG2996	Protein conserved in bacteria
BN85404240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BN85404280	COG1269	ATP hydrolysis coupled proton transport
BN85404340	COG1394	ATPase activity, coupled to movement of substances
BN85404350	COG1823	symporter activity
BN85404360	COG2801	Transposase and inactivated derivatives
BN85404440	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BN85404460	COG0560	Phosphoserine phosphatase
BN85404470	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BN85404480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BN85404510	COG0195	Participates in both transcription termination and antitermination
BN85404520	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BN85404540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BN85404550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BN85404560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BN85404570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BN85404580	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BN85404600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BN85404620	COG2816	NAD+ diphosphatase activity
BN85404630	COG0653	protein targeting
BN85404640	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BN85404650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BN85404660	COG0793	Belongs to the peptidase S41A family
BN85404660	COG3409	Peptidoglycan-binding domain 1 protein
BN85404680	COG0561	phosphatase activity
BN85404700	COG1674	ftsk spoiiie
BN85404710	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BN85404740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BN85404750	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BN85404760	COG0552	protein localization to endoplasmic reticulum
BN85404770	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BN85404780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BN85404790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BN85404790	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BN85404800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BN85404810	COG0237	dephospho-CoA kinase activity
BN85404830	COG1484	DNA-dependent DNA replication
BN85404850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BN85404860	COG4152	abc transporter atp-binding protein
BN85404880	COG0489	protein tyrosine kinase activity
BN85404920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BN85404940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BN85404950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BN85404980	COG0632	four-way junction helicase activity
BN85404990	COG2255	four-way junction helicase activity
BN85405010	COG1968	undecaprenyl-diphosphatase activity
BN85405030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BN85405050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BN85405060	COG1363	Peptidase, m42
BN85405070	COG0656	L-ascorbic acid biosynthetic process
BN85405090	COG0246	Mannitol dehydrogenase
BN85405100	COG2721	sulfolactate sulfo-lyase activity
BN85405110	COG1904	glucuronate isomerase
BN85405130	COG4209	transmembrane transport
BN85405140	COG0395	ABC-type sugar transport system, permease component
BN85405170	COG3842	ATPase activity
BN85405230	COG0363	glucosamine-6-phosphate deaminase activity
BN85405240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BN85405250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BN85405270	COG0174	glutamine synthetase
BN85405320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BN85405340	COG0446	pyridine nucleotide-disulphide oxidoreductase
BN85405350	COG5001	Diguanylate cyclase
BN85405350	COG3300	MHYT domain
BN85405460	COG5001	Diguanylate cyclase
BN85405470	COG1464	Belongs to the NlpA lipoprotein family
BN85405480	COG2011	ABC-type metal ion transport system permease component
BN85405510	COG0328	RNA-DNA hybrid ribonuclease activity
BN85405520	COG2195	Cleaves the N-terminal amino acid of tripeptides
BN85405530	COG1012	belongs to the aldehyde dehydrogenase family
BN85405540	COG1132	(ABC) transporter
BN85405550	COG1132	(ABC) transporter
BN85405560	COG0312	modulator of DNA gyrase
BN85405570	COG0312	modulator of DNA gyrase
BN85405620	COG0803	Belongs to the bacterial solute-binding protein 9 family
BN85405630	COG1121	(ABC) transporter
BN85405640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BN85405650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BN85405660	COG1321	iron dependent repressor
BN85405660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BN85405670	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BN85405690	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BN85405700	COG1760	l-serine dehydratase
BN85405710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BN85405730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BN85405750	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BN85405760	COG4605	iron ion homeostasis
BN85405770	COG4604	ABC transporter, ATP-binding protein
BN85405820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BN85405830	COG1702	phosphate starvation-inducible protein PhoH
BN85405840	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BN85405850	COG0295	cytidine deaminase activity
BN85405890	COG0358	DNA primase activity
BN85405900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BN85405930	COG1132	(ABC) transporter
BN85405960	COG0523	cobalamin synthesis protein
BN85405980	COG2824	Alkylphosphonate utilization operon protein PhnA
BN85405990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BN85406000	COG1121	(ABC) transporter
BN85406040	COG1028	Short-chain dehydrogenase reductase Sdr
BN85406060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BN85406060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BN85406060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BN85406070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BN85406070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BN85406070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BN85406080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BN85406080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BN85406080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BN85406140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BN85406200	COG0584	glycerophosphoryl diester phosphodiesterase
BN85406210	COG1573	uracil-dna glycosylase
BN85406220	COG0800	Aldolase
BN85406240	COG2731	YhcH YjgK YiaL family protein
BN85406290	COG1028	Short-chain dehydrogenase reductase Sdr
BN85406320	COG0443	Heat shock 70 kDa protein
BN85406360	COG4209	transmembrane transport
BN85406370	COG0395	ABC-type sugar transport system, permease component
BN85406420	COG3842	ATPase activity
BN85406440	COG3507	Belongs to the glycosyl hydrolase 43 family
BN85406450	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BN85406470	COG1070	Carbohydrate kinase
BN85406500	COG1012	belongs to the aldehyde dehydrogenase family
BN85406500	COG1454	alcohol dehydrogenase
BN85406510	COG0095	Lipoate-protein ligase
BN85406520	COG0509	glycine decarboxylation via glycine cleavage system
BN85406540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BN85406560	COG0577	efflux transmembrane transporter activity
BN85406580	COG2239	Acts as a magnesium transporter
BN85406590	COG2239	Acts as a magnesium transporter
BN85406660	COG2801	Transposase and inactivated derivatives
BN85406670	COG2801	Transposase and inactivated derivatives
BN85406780	COG0531	amino acid
BN85406820	COG4974	Belongs to the 'phage' integrase family
BN85406840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BN85406870	COG0322	excinuclease ABC activity
BN85406890	COG1132	(ABC) transporter
BN85406900	COG1132	(ABC) transporter
BN85406910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BN85406920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BN85406980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BN85407030	COG0799	negative regulation of ribosome biogenesis
BN85407060	COG2333	competence protein COMEC
BN85407060	COG0658	competence protein
BN85407080	COG1466	dna polymerase III delta subunit
BN85407100	COG0268	Binds directly to 16S ribosomal RNA
BN85407120	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BN85407140	COG1418	mRNA catabolic process
BN85407140	COG4372	Transposase
BN85407150	COG1418	mRNA catabolic process
BN85407160	COG1692	metallophosphoesterase
BN85407190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BN85407200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BN85407210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BN85407230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BN85407240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BN85407250	COG1187	pseudouridine synthase activity
BN85407260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BN85407270	COG0539	negative regulation of cytoplasmic translation
BN85407280	COG1160	GTP binding
BN85407290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BN85407300	COG0776	regulation of translation
BN85407330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BN85407550	COG4974	Belongs to the 'phage' integrase family
BN85407600	COG0488	(ABC) transporter
BN85407610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BN85407630	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BN85407640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BN85407650	COG0006	proline dipeptidase activity
BN85407690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BN85407700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BN85407710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BN85407730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BN85407750	COG1363	Peptidase, m42
BN85407840	COG3331	DNA recombination
BN85407860	COG0488	(ABC) transporter
BN85407870	COG1028	Short-chain dehydrogenase reductase Sdr
BN85407890	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BN85407900	COG0346	lactoylglutathione lyase activity
BN85407910	COG0346	lactoylglutathione lyase activity
BN85407920	COG1846	Transcriptional regulator
BN85407950	COG2755	lipolytic protein G-D-S-L family
BN85407960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BN85407970	COG1132	(ABC) transporter
BN85407980	COG1132	(ABC) transporter
BN85408000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BN85408010	COG0459	protein refolding
BN85408060	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BN85408100	COG0519	Catalyzes the synthesis of GMP from XMP
BN85408180	COG1028	Short-chain dehydrogenase reductase Sdr
BN85408220	COG3279	Response regulator of the LytR AlgR family
BN85408250	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BN85408320	COG1305	Transglutaminase-like
BN85408390	COG1253	flavin adenine dinucleotide binding
BN85408480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BN85408510	COG1744	ABC transporter substrate-binding protein PnrA-like
BN85408570	COG0561	phosphatase activity
BN85408610	COG0778	Nitroreductase
BN85408620	COG1194	a g-specific adenine glycosylase
BN85408640	COG0343	queuine tRNA-ribosyltransferase activity
BN85408650	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BN85408660	COG0012	GTP binding
BN85408670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BN85408690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BN85408730	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BN85408740	COG0813	purine-nucleoside phosphorylase activity
BN85408770	COG0629	single-stranded DNA binding
BN85408780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BN85408790	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BN85408800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BN85408820	COG0588	phosphoglycerate mutase activity
BN85408850	COG0640	Transcriptional regulator
BN85408860	COG2217	Heavy metal translocating P-type atpase
BN85408880	COG0742	ribosomal rna small subunit methyltransferase
BN85408890	COG3763	UPF0154 protein
BN85408910	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BN85408920	COG4974	Belongs to the 'phage' integrase family
BN85408930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BN85408960	COG0481	GTPase activity
BN85408990	COG2267	carboxylic ester hydrolase activity
BN85409000	COG0285	dihydrofolate synthase activity
BN85409020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BN85409070	COG2502	aspartate--ammonia ligase
BN85409090	COG0039	L-malate dehydrogenase activity
BN85409100	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BN85409120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BN85409130	COG0544	peptidyl-prolyl cis-trans isomerase activity
BN85409160	COG1136	(ABC) transporter
BN85409190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BN85409200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BN85409210	COG2746	aminoglycoside 3-N-acetyltransferase activity
BN85409220	COG1185	polyribonucleotide nucleotidyltransferase activity
BN85409240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BN85409250	COG3870	Protein conserved in bacteria
BN85409260	COG0196	riboflavin kinase activity
BN85409270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BN85409300	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BN85409310	COG1472	Belongs to the glycosyl hydrolase 3 family
BN85409320	COG3842	ATPase activity
BN85409390	COG4555	ABC transporter
BN85409420	COG0516	GMP reductase activity
BN85409440	COG1304	FMN binding
BN85409470	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BN85409480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BN85409500	COG0386	Belongs to the glutathione peroxidase family
BN85409520	COG3459	Glycosyltransferase 36 associated
BN85409530	COG0395	ABC-type sugar transport system, permease component
BN85409540	COG1175	transmembrane transport
BN85409590	COG0564	pseudouridine synthase activity
BN85409600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BN85409640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BN85409650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BN85409660	COG0124	histidyl-tRNA synthetase
BN85409690	COG1490	D-aminoacyl-tRNA deacylase activity
BN85409700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BN85409710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BN85409720	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BN85409750	COG0673	inositol 2-dehydrogenase activity
BN85409770	COG2017	converts alpha-aldose to the beta-anomer
BN85409780	COG4948	Mandelate Racemase Muconate Lactonizing
BN85409790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BN85409800	COG0482	sulfurtransferase activity
BN85409820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BN85409840	COG1803	Methylglyoxal synthase
BN85409850	COG0275	rRNA processing
BN85409870	COG0194	GDP metabolic process
BN85409890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BN85409940	COG1131	(ABC) transporter
BN85409950	COG1725	Transcriptional regulator
BN85409980	COG2153	protein acetylation
BN85409990	COG0671	phosphoesterase, PA-phosphatase related
BN85410010	COG0557	exoribonuclease II activity
BN85410020	COG0148	phosphopyruvate hydratase activity
BN85410050	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BN85410090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BN85410100	COG0187	DNA topoisomerase II activity
BN85410130	COG2249	NAD(P)H dehydrogenase (quinone) activity
BN85410140	COG0668	transmembrane transport
BN85410160	COG1187	pseudouridine synthase activity
BN85410170	COG2217	Heavy metal translocating P-type atpase
BN85410180	COG0640	Transcriptional regulator
BN85410190	COG1132	(ABC) transporter
BN85410200	COG1132	(ABC) transporter
BN85410210	COG1846	Transcriptional regulator
BN85410260	COG2081	HI0933 family
BN85410280	COG1192	Involved in chromosome partitioning
BN85410330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BN85410350	COG0438	transferase activity, transferring glycosyl groups
BN85410380	COG0513	Belongs to the DEAD box helicase family
BN85410410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BN85410420	COG0745	RESPONSE REGULATOR receiver
BN85410430	COG2205	protein histidine kinase activity
BN85410460	COG0513	Belongs to the DEAD box helicase family
BN85410470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BN85410490	COG3590	peptidase
BN85410520	COG0170	dolichyl monophosphate biosynthetic process
BN85410530	COG1562	ergosterol biosynthetic process
BN85410540	COG1233	COG1233 Phytoene dehydrogenase and related
BN85410580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BN85410590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BN85410600	COG1272	protein, Hemolysin III
BN85410640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BN85410660	COG0018	arginyl-trna synthetase
BN85410680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BN85410700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BN85410710	COG0497	DNA recombination
BN85410720	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BN85410730	COG1722	exodeoxyribonuclease VII activity
BN85410740	COG1570	exodeoxyribonuclease VII activity
BN85410750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BN85410770	COG1177	transmembrane transport
BN85410780	COG1176	ABC-type spermidine putrescine transport system, permease component I
BN85410790	COG3839	Belongs to the ABC transporter superfamily
BN85410820	COG1177	transmembrane transport
BN85410830	COG1176	ABC-type spermidine putrescine transport system, permease component I
BN85410850	COG1307	EDD domain protein, DegV family
BN85410870	COG0492	ferredoxin-NADP+ reductase activity
BN85410880	COG1268	BioY protein
BN85410890	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BN85410890	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BN85410910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BN85410920	COG1028	Short-chain dehydrogenase reductase Sdr
BN85410930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BN85410950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BN85410970	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BN85410980	COG0439	Biotin carboxylase
BN85411000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BN85411030	COG1584	GPR1 FUN34 yaaH family protein
BN85411050	COG0745	RESPONSE REGULATOR receiver
BN85411060	COG5002	protein histidine kinase activity
BN85411070	COG0438	transferase activity, transferring glycosyl groups
BN85411110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BN85411120	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BN85411150	COG1216	Glycosyl transferase, family 2
BN85411150	COG1442	glycosyl transferase family 8
BN85411170	COG1442	glycosyl transferase family 8
BN85411170	COG1216	Glycosyl transferase, family 2
BN85411180	COG0438	transferase activity, transferring glycosyl groups
BN85411190	COG0438	transferase activity, transferring glycosyl groups
BN85411210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BN85411430	COG1164	Oligoendopeptidase f
BN85411440	COG0556	nucleotide-excision repair
BN85411520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BN85411530	COG1394	ATPase activity, coupled to movement of substances
BN85411590	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BN85411600	COG1269	ATP hydrolysis coupled proton transport
BN85411760	COG1132	(ABC) transporter
BN85411770	COG1132	(ABC) transporter
BN85411800	COG0205	6-phosphofructokinase activity
BN85411830	COG0205	6-phosphofructokinase activity
BN85411850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BN85411860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BN85411870	COG5001	Diguanylate cyclase
BN85411870	COG3300	MHYT domain
BN85411880	COG1132	(ABC) transporter
BN85411890	COG0587	DNA-directed DNA polymerase activity
BN85411920	COG1132	(ABC) transporter
BN85411930	COG1132	(ABC) transporter
BN85411950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BN85411960	COG3935	DnaD domain protein
BN85411970	COG0571	ribonuclease III activity
BN85411980	COG0416	fatty acid biosynthetic process
BN85412000	COG3425	synthase
BN85412080	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BN85412090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BN85412160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BN85412180	COG0287	Prephenate dehydrogenase
BN85412190	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BN85412210	COG1970	mechanosensitive ion channel activity
BN85412230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BN85412240	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BN85412260	COG3481	metal-dependent phosphohydrolase, HD sub domain
BN85412270	COG0617	tRNA 3'-terminal CCA addition
BN85412290	COG1307	EDD domain protein, DegV family
BN85412300	COG1739	Uncharacterized protein family UPF0029
BN85412330	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BN85412340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BN85412350	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BN85412360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BN85412370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BN85412380	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BN85412390	COG0356	it plays a direct role in the translocation of protons across the membrane
BN85412420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BN85412470	COG0009	L-threonylcarbamoyladenylate synthase
BN85412480	COG2890	protein-(glutamine-N5) methyltransferase activity
BN85412490	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BN85412500	COG1132	(ABC) transporter
BN85412510	COG1132	(ABC) transporter
BN85412520	COG0783	Belongs to the Dps family
BN85412530	COG0305	Participates in initiation and elongation during chromosome replication
BN85412540	COG0359	binds to the 23S rRNA
BN85412540	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BN85412550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BN85412560	COG0629	single-stranded DNA binding
BN85412570	COG0360	Binds together with S18 to 16S ribosomal RNA
BN85412580	COG1546	Belongs to the CinA family
BN85412580	COG1058	Belongs to the CinA family
BN85412590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BN85412600	COG0084	hydrolase, TatD family'
BN85412610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BN85412620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BN85412630	COG0049	tRNA binding
BN85412640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BN85412660	COG0569	domain protein
BN85412670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BN85412720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BN85412730	COG0085	RNA polymerase activity
BN85412740	COG2813	Specifically methylates the guanine in position
BN85412750	COG0222	ribosome binding
BN85412760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BN85412770	COG0081	regulation of translation
BN85412780	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BN85412790	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BN85412800	COG2514	catechol 2,3-dioxygenase activity
BN85412810	COG0250	Participates in transcription elongation, termination and antitermination
BN85412830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BN85412850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BN85412860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BN85412870	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BN85412880	COG0215	cysteine-tRNA ligase activity
BN85412900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BN85412910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BN85412920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BN85412930	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BN85412940	COG2233	PERMEase
BN85413000	COG3279	Response regulator of the LytR AlgR family
BN85413040	COG2252	PERMEase
BN85413060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BN85413070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BN85413070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BN85413080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BN85413090	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BN85413100	COG1774	PSP1 C-terminal conserved region
BN85413110	COG0470	DNA polymerase III
BN85413120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BN85413130	COG0101	tRNA pseudouridine synthase activity
BN85413160	COG1122	ATPase activity
BN85413170	COG3118	belongs to the thioredoxin family
BN85413180	COG0492	ferredoxin-NADP+ reductase activity
BN85413220	COG0203	ribosomal protein L17
BN85413230	COG0202	RNA polymerase activity
BN85413240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BN85413250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BN85413260	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BN85413270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BN85413280	COG0024	Methionine aminopeptidase
BN85413290	COG0563	adenylate kinase activity
BN85413300	COG0201	protein transport
BN85413310	COG0200	Binds to the 23S rRNA
BN85413320	COG1841	ribosomal large subunit assembly
BN85413330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BN85413340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BN85413350	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BN85413360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BN85413370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BN85413380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BN85413390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BN85413400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BN85413410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BN85413420	COG0255	Belongs to the universal ribosomal protein uL29 family
BN85413430	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BN85413450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BN85413460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BN85413470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BN85413480	COG0089	rRNA binding
BN85413490	COG0088	Forms part of the polypeptide exit tunnel
BN85413500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BN85413510	COG0051	transcription antitermination factor activity, RNA binding
BN85413530	COG1846	Transcriptional regulator
BN85413550	COG2084	Dehydrogenase
BN85413570	COG1475	DNA binding
BN85413580	COG1192	Involved in chromosome partitioning
BN85413590	COG0357	Ribosomal RNA small subunit methyltransferase G
BN85413600	COG0445	tRNA wobble uridine modification
BN85413610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BN85413630	COG1136	(ABC) transporter
BN85413630	COG0577	efflux transmembrane transporter activity
BN85413640	COG0590	tRNA wobble adenosine to inosine editing
BN85413650	COG1435	thymidine kinase activity
BN85413670	COG2226	methyltransferase
BN85413760	COG1805	sodium ion transport
BN85413770	COG4656	Part of a membrane complex involved in electron transport
BN85413780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BN85413790	COG0217	transcriptional regulatory protein
BN85413830	COG1131	(ABC) transporter
BN85413850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BN85413860	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BN85413880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BN85413890	COG1882	Formate acetyltransferase
BN85413920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BN85413930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BN85413940	COG0424	maF-like protein
BN85413950	COG0037	tRNA processing
BN85413970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BN85413980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BN85413990	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BN85414040	COG0504	CTP synthase activity
BN85414060	COG0688	phosphatidylethanolamine metabolic process
BN85414070	COG1183	phosphatidylcholine synthase activity
BN85414100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BN85414120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BN85414130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BN85414140	COG1285	pathogenesis
BN85414150	COG0037	tRNA processing
BN85414160	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BN85414170	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BN85414210	COG0395	ABC-type sugar transport system, permease component
BN85414230	COG3842	ATPase activity
BN85414250	COG1132	(ABC) transporter
BN85414260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BN85414320	COG2801	Transposase and inactivated derivatives
BN85414340	COG0017	Asparaginyl-tRNA synthetase
BN85414390	COG0706	membrane insertase activity
BN85414400	COG0594	ribonuclease P activity
BN85414410	COG0230	Belongs to the bacterial ribosomal protein bL34 family