locus-tag	class	description
MPAN_000010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MPAN_000020	COG0592	DNA-directed DNA polymerase activity
MPAN_000030	COG2501	S4 domain
MPAN_000040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MPAN_000050	COG0187	DNA topoisomerase II activity
MPAN_000060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MPAN_000070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MPAN_000080	COG2011	ABC-type metal ion transport system permease component
MPAN_000090	COG1464	Belongs to the NlpA lipoprotein family
MPAN_000100	COG1368	sulfuric ester hydrolase activity
MPAN_000120	COG1968	undecaprenyl-diphosphatase activity
MPAN_000140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MPAN_000150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MPAN_000160	COG0745	RESPONSE REGULATOR receiver
MPAN_000170	COG2205	protein histidine kinase activity
MPAN_000170	COG2770	Histidine kinase
MPAN_000180	COG0537	adenosine 5'-monophosphoramidase activity
MPAN_000190	COG4869	propanediol catabolic process
MPAN_000200	COG1078	dGTPase activity
MPAN_000220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MPAN_000230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MPAN_000240	COG2088	sporulation resulting in formation of a cellular spore
MPAN_000250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MPAN_000260	COG0193	aminoacyl-tRNA hydrolase activity
MPAN_000270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MPAN_000290	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MPAN_000320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MPAN_000330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MPAN_000330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MPAN_000350	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MPAN_000360	COG1307	EDD domain protein, DegV family
MPAN_000410	COG0789	Transcriptional regulator
MPAN_000420	COG1098	S1 RNA binding domain
MPAN_000440	COG0802	atpase or kinase
MPAN_000450	COG1214	PFAM Peptidase M22, glycoprotease
MPAN_000470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MPAN_000490	COG2226	methyltransferase
MPAN_000510	COG0210	DNA helicase
MPAN_000530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MPAN_000580	COG0546	phosphoglycolate phosphatase activity
MPAN_000590	COG0492	ferredoxin-NADP+ reductase activity
MPAN_000610	COG0736	holo-[acyl-carrier-protein] synthase activity
MPAN_000630	COG2183	response to ionizing radiation
MPAN_000710	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MPAN_000840	COG2003	Belongs to the UPF0758 family
MPAN_000960	COG0514	ATP-dependent DNA helicase (RecQ)
MPAN_001050	COG1131	(ABC) transporter
MPAN_001100	COG1695	Transcriptional regulator
MPAN_001190	COG0513	Belongs to the DEAD box helicase family
MPAN_001200	COG0513	Belongs to the DEAD box helicase family
MPAN_001210	COG0656	L-ascorbic acid biosynthetic process
MPAN_001220	COG1028	Short-chain dehydrogenase reductase Sdr
MPAN_001370	COG0577	efflux transmembrane transporter activity
MPAN_001370	COG1136	(ABC) transporter
MPAN_001380	COG0745	RESPONSE REGULATOR receiver
MPAN_001410	COG1278	Cold shock
MPAN_001470	COG5001	Diguanylate cyclase
MPAN_001470	COG3300	MHYT domain
MPAN_001480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MPAN_001500	COG0667	Aldo Keto reductase
MPAN_001520	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MPAN_001530	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MPAN_001540	COG1609	Transcriptional regulator
MPAN_001550	COG0534	Mate efflux family protein
MPAN_001560	COG3404	Formiminotransferase-cyclodeaminase
MPAN_001570	COG1228	amidohydrolase
MPAN_001590	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MPAN_001600	COG2986	histidine ammonia-lyase
MPAN_001620	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MPAN_001620	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MPAN_001670	COG3052	prosthetic group binding
MPAN_001690	COG4865	methylaspartate mutase activity
MPAN_001710	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPAN_001730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MPAN_001740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MPAN_001760	COG0037	tRNA processing
MPAN_001780	COG0366	Alpha amylase catalytic
MPAN_001790	COG3345	alpha-galactosidase
MPAN_001810	COG1472	Belongs to the glycosyl hydrolase 3 family
MPAN_001820	COG2211	Major facilitator Superfamily
MPAN_001830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MPAN_001840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MPAN_001850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MPAN_001860	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MPAN_001870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MPAN_001890	COG0217	transcriptional regulatory protein
MPAN_001900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MPAN_001920	COG1805	sodium ion transport
MPAN_001960	COG4657	Part of a membrane complex involved in electron transport
MPAN_001980	COG2878	Part of a membrane complex involved in electron transport
MPAN_002020	COG0254	rRNA binding
MPAN_002030	COG1435	thymidine kinase activity
MPAN_002040	COG0590	tRNA wobble adenosine to inosine editing
MPAN_002060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MPAN_002070	COG0445	tRNA wobble uridine modification
MPAN_002080	COG0357	Ribosomal RNA small subunit methyltransferase G
MPAN_002090	COG1192	Involved in chromosome partitioning
MPAN_002100	COG1475	DNA binding
MPAN_002120	COG2433	Pfam Transposase IS66
MPAN_002170	COG1307	EDD domain protein, DegV family
MPAN_002190	COG1940	carbohydrate kinase activity
MPAN_002210	COG0051	transcription antitermination factor activity, RNA binding
MPAN_002220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MPAN_002230	COG0088	Forms part of the polypeptide exit tunnel
MPAN_002240	COG0089	rRNA binding
MPAN_002250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MPAN_002260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MPAN_002270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MPAN_002290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MPAN_002300	COG0255	Belongs to the universal ribosomal protein uL29 family
MPAN_002310	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MPAN_002320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MPAN_002330	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MPAN_002340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MPAN_002350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MPAN_002360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MPAN_002370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MPAN_002380	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MPAN_002390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MPAN_002400	COG1841	ribosomal large subunit assembly
MPAN_002410	COG0200	Binds to the 23S rRNA
MPAN_002420	COG0201	protein transport
MPAN_002430	COG0563	adenylate kinase activity
MPAN_002440	COG0024	Methionine aminopeptidase
MPAN_002450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MPAN_002460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MPAN_002470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MPAN_002480	COG0202	RNA polymerase activity
MPAN_002490	COG0203	ribosomal protein L17
MPAN_002500	COG2356	endonuclease I
MPAN_002510	COG0667	Aldo Keto reductase
MPAN_002530	COG1131	(ABC) transporter
MPAN_002570	COG2081	HI0933 family
MPAN_002580	COG0492	ferredoxin-NADP+ reductase activity
MPAN_002590	COG3118	belongs to the thioredoxin family
MPAN_002610	COG1122	ATPase activity
MPAN_002620	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MPAN_002630	COG0101	tRNA pseudouridine synthase activity
MPAN_002640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MPAN_002650	COG0470	DNA polymerase III
MPAN_002660	COG1774	PSP1 C-terminal conserved region
MPAN_002670	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MPAN_002690	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MPAN_002710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MPAN_002720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MPAN_002720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MPAN_002720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MPAN_002730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MPAN_002730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MPAN_002730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MPAN_002750	COG2252	PERMEase
MPAN_002760	COG0531	amino acid
MPAN_002780	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MPAN_002790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MPAN_002800	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MPAN_002830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MPAN_002850	COG2251	uridine kinase activity
MPAN_002860	COG0215	cysteine-tRNA ligase activity
MPAN_002870	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MPAN_002880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MPAN_002910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MPAN_002930	COG0250	Participates in transcription elongation, termination and antitermination
MPAN_002940	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MPAN_002960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MPAN_002980	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MPAN_002990	COG0222	ribosome binding
MPAN_003000	COG2813	Specifically methylates the guanine in position
MPAN_003010	COG0085	RNA polymerase activity
MPAN_003020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MPAN_003050	COG0156	8-amino-7-oxononanoate synthase activity
MPAN_003060	COG0300	oxidoreductase activity
MPAN_003080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MPAN_003090	COG0049	tRNA binding
MPAN_003100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MPAN_003110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MPAN_003130	COG0084	hydrolase, TatD family'
MPAN_003140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPAN_003150	COG1546	Belongs to the CinA family
MPAN_003150	COG1058	Belongs to the CinA family
MPAN_003160	COG0360	Binds together with S18 to 16S ribosomal RNA
MPAN_003170	COG0629	single-stranded DNA binding
MPAN_003180	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MPAN_003240	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MPAN_003240	COG0359	binds to the 23S rRNA
MPAN_003250	COG0305	Participates in initiation and elongation during chromosome replication
MPAN_003260	COG0783	Belongs to the Dps family
MPAN_003270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MPAN_003280	COG2890	protein-(glutamine-N5) methyltransferase activity
MPAN_003300	COG1217	gtp-binding protein TYPA
MPAN_003310	COG0698	ribose 5-phosphate isomerase
MPAN_003320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MPAN_003360	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MPAN_003380	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MPAN_003390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MPAN_003410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MPAN_003420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MPAN_003450	COG1739	Uncharacterized protein family UPF0029
MPAN_003460	COG1307	EDD domain protein, DegV family
MPAN_003470	COG0617	tRNA 3'-terminal CCA addition
MPAN_003480	COG3481	metal-dependent phosphohydrolase, HD sub domain
MPAN_003490	COG2826	transposase and inactivated derivatives, IS30 family
MPAN_003510	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MPAN_003520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MPAN_003560	COG2356	endonuclease I
MPAN_003630	COG1132	(ABC) transporter
MPAN_003640	COG1970	mechanosensitive ion channel activity
MPAN_003650	COG1307	EDD domain protein, DegV family
MPAN_003690	COG1695	Transcriptional regulator
MPAN_003700	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MPAN_003710	COG0287	Prephenate dehydrogenase
MPAN_003730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MPAN_003750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MPAN_003760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MPAN_003770	COG0640	Transcriptional regulator
MPAN_003780	COG2217	Heavy metal translocating P-type atpase
MPAN_003790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MPAN_003800	COG0416	fatty acid biosynthetic process
MPAN_003810	COG0571	ribonuclease III activity
MPAN_003830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MPAN_003850	COG1132	(ABC) transporter
MPAN_003860	COG1132	(ABC) transporter
MPAN_003900	COG0587	DNA-directed DNA polymerase activity
MPAN_003930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MPAN_003960	COG0205	6-phosphofructokinase activity
MPAN_003970	COG0205	6-phosphofructokinase activity
MPAN_003980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MPAN_003980	COG0574	Belongs to the PEP-utilizing enzyme family
MPAN_004020	COG0704	Plays a role in the regulation of phosphate uptake
MPAN_004030	COG0556	nucleotide-excision repair
MPAN_004060	COG2195	Cleaves the N-terminal amino acid of tripeptides
MPAN_004110	COG1132	(ABC) transporter
MPAN_004120	COG1132	(ABC) transporter
MPAN_004140	COG1321	iron dependent repressor
MPAN_004140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MPAN_004150	COG2239	Acts as a magnesium transporter
MPAN_004160	COG2239	Acts as a magnesium transporter
MPAN_004170	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MPAN_004180	COG1760	l-serine dehydratase
MPAN_004190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MPAN_004230	COG5002	protein histidine kinase activity
MPAN_004230	COG0784	Response regulator, receiver
MPAN_004230	COG2205	protein histidine kinase activity
MPAN_004240	COG3437	response regulator, receiver
MPAN_004270	COG1045	serine acetyltransferase
MPAN_004280	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MPAN_004290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MPAN_004310	COG1702	phosphate starvation-inducible protein PhoH
MPAN_004320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MPAN_004330	COG0295	cytidine deaminase activity
MPAN_004350	COG1381	Involved in DNA repair and RecF pathway recombination
MPAN_004360	COG0423	glycine-tRNA ligase activity
MPAN_004370	COG0358	DNA primase activity
MPAN_004380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MPAN_004420	COG0582	viral genome integration into host DNA
MPAN_004510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPAN_004620	COG2433	Pfam Transposase IS66
MPAN_004650	COG0693	protein deglycase activity
MPAN_004670	COG0561	phosphatase activity
MPAN_004720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MPAN_004730	COG1459	type II secretion system
MPAN_004740	COG4969	Belongs to the N-Me-Phe pilin family
MPAN_004750	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MPAN_004790	COG1674	ftsk spoiiie
MPAN_004810	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MPAN_004820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MPAN_004840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MPAN_004850	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MPAN_004860	COG0552	protein localization to endoplasmic reticulum
MPAN_004870	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MPAN_004880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MPAN_004890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MPAN_004890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MPAN_004900	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MPAN_004910	COG0237	dephospho-CoA kinase activity
MPAN_004930	COG1484	DNA-dependent DNA replication
MPAN_004940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MPAN_004950	COG4152	abc transporter atp-binding protein
MPAN_005010	COG1263	PTS System
MPAN_005010	COG2190	(PTS) system
MPAN_005010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MPAN_005020	COG0489	protein tyrosine kinase activity
MPAN_005030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MPAN_005040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MPAN_005050	COG0509	glycine decarboxylation via glycine cleavage system
MPAN_005060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MPAN_005070	COG2267	carboxylic ester hydrolase activity
MPAN_005080	COG2084	Dehydrogenase
MPAN_005100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MPAN_005110	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MPAN_005140	COG0557	exoribonuclease II activity
MPAN_005150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MPAN_005170	COG0671	phosphoesterase, PA-phosphatase related
MPAN_005190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MPAN_005200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MPAN_005220	COG4122	O-methyltransferase activity
MPAN_005240	COG0826	peptidase U32
MPAN_005260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MPAN_005400	COG1466	dna polymerase III delta subunit
MPAN_005410	COG2176	DNA-directed DNA polymerase activity
MPAN_005420	COG0268	Binds directly to 16S ribosomal RNA
MPAN_005440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MPAN_005450	COG3681	Belongs to the UPF0597 family
MPAN_005470	COG1136	(ABC) transporter
MPAN_005470	COG0577	efflux transmembrane transporter activity
MPAN_005480	COG1136	(ABC) transporter
MPAN_005520	COG4372	Transposase
MPAN_005520	COG1418	mRNA catabolic process
MPAN_005530	COG1692	metallophosphoesterase
MPAN_005540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MPAN_005570	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MPAN_005580	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MPAN_005590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MPAN_005600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MPAN_005610	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MPAN_005620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MPAN_005630	COG1187	pseudouridine synthase activity
MPAN_005640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MPAN_005660	COG1160	GTP binding
MPAN_005670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MPAN_005680	COG0776	regulation of translation
MPAN_005780	COG0561	phosphatase activity
MPAN_005820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MPAN_005840	COG1342	Belongs to the UPF0251 family
MPAN_005850	COG1266	CAAX protease self-immunity
MPAN_005860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MPAN_005940	COG1902	pentaerythritol trinitrate reductase activity
MPAN_006070	COG0494	nUDIX hydrolase
MPAN_006120	COG1863	multisubunit Na H antiporter MnhE subunit
MPAN_006130	COG2212	antiporter activity
MPAN_006140	COG1320	monovalent cation:proton antiporter activity
MPAN_006160	COG2111	Na H antiporter
MPAN_006170	COG1006	Multisubunit Na H antiporter MnhC subunit
MPAN_006180	COG0651	ATP synthesis coupled electron transport
MPAN_006190	COG0651	ATP synthesis coupled electron transport
MPAN_006200	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MPAN_006210	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MPAN_006220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MPAN_006230	COG0649	NAD binding
MPAN_006240	COG0493	'glutamate synthase
MPAN_006270	COG0668	transmembrane transport
MPAN_006330	COG0659	secondary active sulfate transmembrane transporter activity
MPAN_006420	COG0446	pyridine nucleotide-disulphide oxidoreductase
MPAN_006440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MPAN_006460	COG1116	anion transmembrane transporter activity
MPAN_006470	COG1028	Short-chain dehydrogenase reductase Sdr
MPAN_006480	COG2199	diguanylate cyclase activity
MPAN_006480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MPAN_006490	COG2199	diguanylate cyclase activity
MPAN_006490	COG2203	Gaf domain
MPAN_006510	COG0745	RESPONSE REGULATOR receiver
MPAN_006520	COG5002	protein histidine kinase activity
MPAN_006530	COG0543	2 iron, 2 sulfur cluster binding
MPAN_006530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MPAN_006600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MPAN_006610	COG0673	inositol 2-dehydrogenase activity
MPAN_006680	COG1104	cysteine desulfurase activity
MPAN_006700	COG5001	Diguanylate cyclase
MPAN_006740	COG5520	Belongs to the glycosyl hydrolase 30 family
MPAN_006760	COG2801	Transposase and inactivated derivatives
MPAN_006860	COG0395	ABC-type sugar transport system, permease component
MPAN_006890	COG1175	transmembrane transport
MPAN_006900	COG0395	ABC-type sugar transport system, permease component
MPAN_006930	COG0745	RESPONSE REGULATOR receiver
MPAN_007050	COG0488	(ABC) transporter
MPAN_007070	COG2217	Heavy metal translocating P-type atpase
MPAN_007110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MPAN_007120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MPAN_007130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPAN_007140	COG1420	regulation of RNA biosynthetic process
MPAN_007150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MPAN_007160	COG0443	Heat shock 70 kDa protein
MPAN_007180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MPAN_007190	COG1461	Dihydroxyacetone kinase
MPAN_007210	COG0095	Lipoate-protein ligase
MPAN_007240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MPAN_007250	COG0275	rRNA processing
MPAN_007260	COG1803	Methylglyoxal synthase
MPAN_007280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MPAN_007290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MPAN_007290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MPAN_007300	COG0482	sulfurtransferase activity
MPAN_007310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MPAN_007340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MPAN_007350	COG0297	glycogen (starch) synthase activity
MPAN_007370	COG0686	Belongs to the AlaDH PNT family
MPAN_007410	COG2135	peptidase activity
MPAN_007460	COG0400	carboxylic ester hydrolase activity
MPAN_007480	COG0154	amidase activity
MPAN_007490	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MPAN_007500	COG0446	pyridine nucleotide-disulphide oxidoreductase
MPAN_007600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MPAN_007660	COG1132	(ABC) transporter
MPAN_007700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MPAN_007720	COG4106	trans-aconitate 2-methyltransferase activity
MPAN_007760	COG0697	spore germination
MPAN_007820	COG4175	Glycine betaine
MPAN_007820	COG3448	diguanylate cyclase activity
MPAN_007830	COG0516	GMP reductase activity
MPAN_007860	COG0564	pseudouridine synthase activity
MPAN_007880	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MPAN_007890	COG0584	glycerophosphoryl diester phosphodiesterase
MPAN_007910	COG1695	Transcriptional regulator
MPAN_007990	COG0426	domain, Protein
MPAN_008000	COG0275	rRNA processing
MPAN_008050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MPAN_008070	COG2226	methyltransferase
MPAN_008080	COG3590	peptidase
MPAN_008090	COG5002	protein histidine kinase activity
MPAN_008100	COG0745	RESPONSE REGULATOR receiver
MPAN_008170	COG0546	phosphoglycolate phosphatase activity
MPAN_008180	COG0577	efflux transmembrane transporter activity
MPAN_008180	COG1136	(ABC) transporter
MPAN_008190	COG1136	(ABC) transporter
MPAN_008190	COG0577	efflux transmembrane transporter activity
MPAN_008210	COG0778	Nitroreductase
MPAN_008230	COG1194	a g-specific adenine glycosylase
MPAN_008260	COG0343	queuine tRNA-ribosyltransferase activity
MPAN_008270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MPAN_008280	COG0012	GTP binding
MPAN_008290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MPAN_008300	COG1799	cell septum assembly
MPAN_008310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MPAN_008320	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MPAN_008360	COG0813	purine-nucleoside phosphorylase activity
MPAN_008390	COG0629	single-stranded DNA binding
MPAN_008400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MPAN_008410	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MPAN_008420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MPAN_008440	COG0406	alpha-ribazole phosphatase activity
MPAN_008460	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MPAN_008530	COG3331	DNA recombination
MPAN_008540	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MPAN_008560	COG3804	dihydrodipicolinate reductase
MPAN_008600	COG5012	cobalamin binding
MPAN_008620	COG3457	Alanine racemase
MPAN_008640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MPAN_008650	COG0488	(ABC) transporter
MPAN_008660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MPAN_008670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MPAN_008680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MPAN_008690	COG1490	D-aminoacyl-tRNA deacylase activity
MPAN_008700	COG0519	Catalyzes the synthesis of GMP from XMP
MPAN_008710	COG0124	histidyl-tRNA synthetase
MPAN_008720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MPAN_008760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MPAN_008770	COG0564	pseudouridine synthase activity
MPAN_008780	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MPAN_008790	COG1193	negative regulation of DNA recombination
MPAN_008800	COG3118	belongs to the thioredoxin family
MPAN_008810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MPAN_008820	COG0196	riboflavin kinase activity
MPAN_008830	COG3870	Protein conserved in bacteria
MPAN_008850	COG1185	polyribonucleotide nucleotidyltransferase activity
MPAN_008860	COG1253	flavin adenine dinucleotide binding
MPAN_008880	COG0596	Alpha beta hydrolase
MPAN_008910	COG1253	flavin adenine dinucleotide binding
MPAN_008920	COG4536	flavin adenine dinucleotide binding
MPAN_008940	COG0481	GTPase activity
MPAN_008950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MPAN_008960	COG4974	Belongs to the 'phage' integrase family
MPAN_008970	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MPAN_009000	COG0252	asparaginase activity
MPAN_009010	COG2267	carboxylic ester hydrolase activity
MPAN_009040	COG0427	acetyl-CoA hydrolase
MPAN_009070	COG0411	ABC transporter
MPAN_009110	COG1028	Short-chain dehydrogenase reductase Sdr
MPAN_009120	COG0183	Belongs to the thiolase family
MPAN_009130	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MPAN_009140	COG2086	electron transfer activity
MPAN_009150	COG1960	acyl-CoA dehydrogenase activity
MPAN_009160	COG2030	dehydratase
MPAN_009170	COG1309	transcriptional regulator
MPAN_009190	COG0742	ribosomal rna small subunit methyltransferase
MPAN_009200	COG1363	Peptidase, m42
MPAN_009220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MPAN_009230	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MPAN_009240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MPAN_009260	COG4152	abc transporter atp-binding protein
MPAN_009290	COG0006	proline dipeptidase activity
MPAN_009300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MPAN_009310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MPAN_009340	COG1704	LemA family
MPAN_009350	COG0656	L-ascorbic acid biosynthetic process
MPAN_009360	COG1363	Peptidase, m42
MPAN_009380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MPAN_009410	COG2255	four-way junction helicase activity
MPAN_009420	COG0632	four-way junction helicase activity
MPAN_009440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MPAN_009450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MPAN_009470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MPAN_009500	COG0285	dihydrofolate synthase activity
MPAN_009510	COG0525	valine-tRNA ligase activity
MPAN_009530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MPAN_009540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPAN_009550	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MPAN_009560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MPAN_009570	COG0544	peptidyl-prolyl cis-trans isomerase activity
MPAN_009620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MPAN_009660	COG0489	protein tyrosine kinase activity
MPAN_009680	COG1164	Oligoendopeptidase f
MPAN_009690	COG0174	glutamine synthetase
MPAN_009750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MPAN_009760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MPAN_009770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MPAN_009780	COG1088	dTDP-glucose 4,6-dehydratase activity
MPAN_009790	COG1091	dTDP-4-dehydrorhamnose reductase activity
MPAN_009930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MPAN_009940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MPAN_010250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MPAN_010330	COG4974	Belongs to the 'phage' integrase family
MPAN_010520	COG5016	pyruvate
MPAN_010520	COG0511	ligase activity, forming carbon-carbon bonds
MPAN_010550	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MPAN_010570	COG3547	Transposase (IS116 IS110 IS902 family)
MPAN_010640	COG0583	DNA-binding transcription factor activity
MPAN_010690	COG0745	RESPONSE REGULATOR receiver
MPAN_010700	COG1482	cell wall glycoprotein biosynthetic process
MPAN_010710	COG1482	cell wall glycoprotein biosynthetic process
MPAN_010730	COG1929	Belongs to the glycerate kinase type-1 family
MPAN_010740	COG1744	ABC transporter substrate-binding protein PnrA-like
MPAN_010750	COG3845	ABC transporter
MPAN_010760	COG4603	Belongs to the binding-protein-dependent transport system permease family
MPAN_010770	COG1079	Belongs to the binding-protein-dependent transport system permease family
MPAN_010830	COG0110	maltose O-acetyltransferase activity
MPAN_010860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MPAN_010870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MPAN_010880	COG1272	protein, Hemolysin III
MPAN_010890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MPAN_010900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MPAN_010910	COG3022	response to hydroperoxide
MPAN_010920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MPAN_010960	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MPAN_010980	COG0366	Alpha amylase catalytic
MPAN_011040	COG0018	arginyl-trna synthetase
MPAN_011060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MPAN_011070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MPAN_011080	COG0297	glycogen (starch) synthase activity
MPAN_011090	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MPAN_011140	COG0497	DNA recombination
MPAN_011160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MPAN_011170	COG1722	exodeoxyribonuclease VII activity
MPAN_011180	COG1570	exodeoxyribonuclease VII activity
MPAN_011190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MPAN_011210	COG1177	transmembrane transport
MPAN_011220	COG1176	ABC-type spermidine putrescine transport system, permease component I
MPAN_011230	COG3839	Belongs to the ABC transporter superfamily
MPAN_011250	COG1309	transcriptional regulator
MPAN_011430	COG5001	Diguanylate cyclase
MPAN_011430	COG3300	MHYT domain
MPAN_011440	COG2205	protein histidine kinase activity
MPAN_011440	COG2198	Histidine kinase
MPAN_011440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MPAN_011440	COG0784	Response regulator, receiver
MPAN_011450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MPAN_011460	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MPAN_011480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MPAN_011560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MPAN_011580	COG5001	Diguanylate cyclase
MPAN_011590	COG0156	8-amino-7-oxononanoate synthase activity
MPAN_011600	COG1063	alcohol dehydrogenase
MPAN_011610	COG0494	nUDIX hydrolase
MPAN_011640	COG1012	belongs to the aldehyde dehydrogenase family
MPAN_011730	COG0534	Mate efflux family protein
MPAN_011740	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
MPAN_011790	COG0569	domain protein
MPAN_011840	COG0489	protein tyrosine kinase activity
MPAN_011890	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MPAN_011890	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MPAN_011910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MPAN_011920	COG1028	Short-chain dehydrogenase reductase Sdr
MPAN_011940	COG2070	2-Nitropropane dioxygenase
MPAN_011950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MPAN_011970	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MPAN_011980	COG0439	Biotin carboxylase
MPAN_012000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MPAN_012020	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MPAN_012030	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MPAN_012100	COG0748	coenzyme F420 binding
MPAN_012160	COG0386	Belongs to the glutathione peroxidase family
MPAN_012220	COG0513	Belongs to the DEAD box helicase family
MPAN_012240	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MPAN_012250	COG2137	regulation of response to DNA damage stimulus
MPAN_012260	COG0793	Belongs to the peptidase S41A family
MPAN_012260	COG3409	Peptidoglycan-binding domain 1 protein
MPAN_012270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MPAN_012280	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MPAN_012290	COG0653	protein targeting
MPAN_012320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MPAN_012340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MPAN_012350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MPAN_012360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MPAN_012370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MPAN_012380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MPAN_012400	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MPAN_012410	COG0195	Participates in both transcription termination and antitermination
MPAN_012410	COG2251	uridine kinase activity
MPAN_012420	COG0779	Required for maturation of 30S ribosomal subunits
MPAN_012440	COG1121	(ABC) transporter
MPAN_012450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MPAN_012450	COG1321	iron dependent repressor
MPAN_012470	COG0656	L-ascorbic acid biosynthetic process
MPAN_012490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MPAN_012500	COG0561	phosphatase activity
MPAN_012510	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MPAN_012540	COG1758	RNA polymerase activity
MPAN_012550	COG0194	GDP metabolic process
MPAN_012570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MPAN_012590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MPAN_012610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MPAN_012620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MPAN_012630	COG1394	ATPase activity, coupled to movement of substances
MPAN_012690	COG1269	ATP hydrolysis coupled proton transport
MPAN_012720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MPAN_012740	COG2996	Protein conserved in bacteria
MPAN_012760	COG1126	abc transporter atp-binding protein
MPAN_012770	COG0765	amino acid transport
MPAN_012790	COG1278	Cold shock
MPAN_012810	COG1132	(ABC) transporter
MPAN_012820	COG1132	(ABC) transporter
MPAN_012840	COG2356	endonuclease I
MPAN_012890	COG3557	Belongs to the UPF0374 family
MPAN_012920	COG0009	L-threonylcarbamoyladenylate synthase
MPAN_013020	COG1461	Dihydroxyacetone kinase
MPAN_013030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MPAN_013060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MPAN_013070	COG1162	GTPase activity
MPAN_013080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MPAN_013090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MPAN_013090	COG0072	phenylalanine-tRNA ligase activity
MPAN_013100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MPAN_013120	COG2176	DNA-directed DNA polymerase activity
MPAN_013140	COG1242	4 iron, 4 sulfur cluster binding
MPAN_013150	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MPAN_013180	COG1595	DNA-templated transcription, initiation
MPAN_013190	COG0495	leucyl-tRNA aminoacylation
MPAN_013220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MPAN_013230	COG0765	amino acid transport
MPAN_013240	COG1126	abc transporter atp-binding protein
MPAN_013250	COG2826	transposase and inactivated derivatives, IS30 family
MPAN_013270	COG0366	Alpha amylase catalytic
MPAN_013290	COG1609	Transcriptional regulator
MPAN_013310	COG1523	belongs to the glycosyl hydrolase 13 family
MPAN_013320	COG0366	Alpha amylase catalytic
MPAN_013330	COG0058	SHG alpha-glucan phosphorylase activity
MPAN_013340	COG3833	ABC-type maltose transport systems, permease component
MPAN_013350	COG1175	transmembrane transport
MPAN_013360	COG2182	Extracellular solute-binding protein
MPAN_013380	COG1523	belongs to the glycosyl hydrolase 13 family
MPAN_013400	COG0598	Magnesium transport protein CorA
MPAN_013530	COG0366	Alpha amylase catalytic
MPAN_013550	COG0737	Belongs to the 5'-nucleotidase family
MPAN_013560	COG2059	Chromate
MPAN_013580	COG0584	glycerophosphoryl diester phosphodiesterase
MPAN_013590	COG1368	sulfuric ester hydrolase activity
MPAN_013670	COG0657	acetylesterase activity
MPAN_013700	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MPAN_013720	COG4221	oxidoreductase activity
MPAN_013730	COG2235	arginine
MPAN_013750	COG1811	Na channel or pump
MPAN_013760	COG0667	Aldo Keto reductase
MPAN_013850	COG0701	Predicted permease
MPAN_013870	COG0330	HflC and HflK could
MPAN_013920	COG0823	Involved in the tonB-independent uptake of proteins
MPAN_013920	COG4946	Tricorn protease homolog
MPAN_013920	COG1506	peptidase
MPAN_013940	COG3706	GGDEF domain
MPAN_013960	COG0469	pyruvate kinase activity
MPAN_013990	COG0628	permease
MPAN_014130	COG2217	Heavy metal translocating P-type atpase
MPAN_014140	COG0750	zinc metalloprotease
MPAN_014150	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MPAN_014160	COG4589	Belongs to the CDS family
MPAN_014170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MPAN_014180	COG0233	cytoplasmic translational termination
MPAN_014190	COG0528	UMP kinase activity
MPAN_014200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MPAN_014210	COG0052	Belongs to the universal ribosomal protein uS2 family
MPAN_014220	COG0756	dUTP diphosphatase activity
MPAN_014240	COG4974	Belongs to the 'phage' integrase family
MPAN_014250	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MPAN_014270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MPAN_014350	COG4116	CYTH
MPAN_014370	COG1393	Belongs to the ArsC family
MPAN_014380	COG1164	Oligoendopeptidase f
MPAN_014390	COG0180	Tryptophanyl-tRNA synthetase
MPAN_014420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MPAN_014430	COG1609	Transcriptional regulator
MPAN_014440	COG0335	large ribosomal subunit rRNA binding
MPAN_014450	COG0336	Belongs to the RNA methyltransferase TrmD family
MPAN_014460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MPAN_014470	COG1837	Belongs to the UPF0109 family
MPAN_014480	COG0228	four-way junction DNA binding
MPAN_014510	COG1187	pseudouridine synthase activity
MPAN_014520	COG0242	peptide deformylase activity
MPAN_014540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MPAN_014550	COG0301	tRNA thio-modification
MPAN_014560	COG1956	GAF domain-containing protein
MPAN_014570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MPAN_014590	COG0149	triose-phosphate isomerase activity
MPAN_014600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MPAN_014620	COG0126	phosphoglycerate kinase activity
MPAN_014640	COG3842	ATPase activity
MPAN_014650	COG2508	Transcriptional regulator
MPAN_014670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPAN_014690	COG0822	iron-sulfur transferase activity
MPAN_014700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MPAN_014710	COG0719	Fe-S assembly protein
MPAN_014720	COG0396	ATPase activity
MPAN_014760	COG4608	Belongs to the ABC transporter superfamily
MPAN_014770	COG0444	Belongs to the ABC transporter superfamily
MPAN_014780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MPAN_014790	COG0601	transmembrane transport
MPAN_014820	COG0674	pyruvate-flavodoxin oxidoreductase activity
MPAN_014820	COG1013	pyruvate-flavodoxin oxidoreductase activity
MPAN_014820	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MPAN_014820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MPAN_014830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MPAN_015010	COG5002	protein histidine kinase activity
MPAN_015020	COG0745	RESPONSE REGULATOR receiver
MPAN_015030	COG0704	Plays a role in the regulation of phosphate uptake
MPAN_015040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MPAN_015050	COG0581	inorganic phosphate transmembrane transporter activity
MPAN_015060	COG0573	inorganic phosphate transmembrane transporter activity
MPAN_015080	COG1131	(ABC) transporter
MPAN_015130	COG1131	(ABC) transporter
MPAN_015180	COG1136	(ABC) transporter
MPAN_015200	COG1307	EDD domain protein, DegV family
MPAN_015210	COG2814	Major facilitator Superfamily
MPAN_015240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MPAN_015250	COG1473	amidohydrolase
MPAN_015260	COG0174	glutamine synthetase
MPAN_015410	COG0708	Exodeoxyribonuclease III
MPAN_015450	COG5002	protein histidine kinase activity
MPAN_015460	COG0745	RESPONSE REGULATOR receiver
MPAN_015510	COG1695	Transcriptional regulator
MPAN_015540	COG3547	Transposase (IS116 IS110 IS902 family)
MPAN_015560	COG0513	Belongs to the DEAD box helicase family
MPAN_015610	COG4895	conserved protein (DUF2196)
MPAN_015620	COG3839	Belongs to the ABC transporter superfamily
MPAN_015710	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MPAN_015780	COG1309	transcriptional regulator
MPAN_015840	COG4211	Belongs to the binding-protein-dependent transport system permease family
MPAN_015850	COG1129	ABC transporter
MPAN_015880	COG2972	Histidine kinase
MPAN_015890	COG2207	Transcriptional regulator
MPAN_015890	COG4753	response regulator
MPAN_015940	COG2770	Histidine kinase
MPAN_015940	COG3437	response regulator, receiver
MPAN_015970	COG5012	cobalamin binding
MPAN_015980	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MPAN_016010	COG0604	alcohol dehydrogenase
MPAN_016020	COG3246	L-lysine catabolic process to acetate
MPAN_016030	COG1607	acyl-coa hydrolase
MPAN_016050	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MPAN_016070	COG0590	tRNA wobble adenosine to inosine editing
MPAN_016100	COG1811	Na channel or pump
MPAN_016120	COG1172	Belongs to the binding-protein-dependent transport system permease family
MPAN_016130	COG1129	ABC transporter
MPAN_016150	COG0583	DNA-binding transcription factor activity
MPAN_016160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MPAN_016170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MPAN_016180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MPAN_016200	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MPAN_016240	COG0167	dihydroorotate dehydrogenase activity
MPAN_016250	COG0402	S-adenosylhomocysteine deaminase activity
MPAN_016260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MPAN_016280	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MPAN_016280	COG3608	succinylglutamate desuccinylase aspartoacylase
MPAN_016310	COG2080	2 iron, 2 sulfur cluster binding
MPAN_016430	COG3177	Filamentation induced by cAMP protein fic
MPAN_016450	COG1597	lipid kinase activity
MPAN_016510	COG0010	Belongs to the arginase family
MPAN_016520	COG1982	Orn Lys Arg decarboxylase major
MPAN_016530	COG0668	transmembrane transport
MPAN_016570	COG3706	GGDEF domain
MPAN_016610	COG0280	phosphate acetyltransferase
MPAN_016620	COG3426	butyrate kinase activity
MPAN_016630	COG0501	Belongs to the peptidase M48B family
MPAN_016640	COG3033	Beta-eliminating lyase
MPAN_016690	COG1126	abc transporter atp-binding protein
MPAN_016740	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MPAN_016750	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MPAN_016760	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MPAN_016770	COG4658	electron transport chain
MPAN_016780	COG1012	belongs to the aldehyde dehydrogenase family
MPAN_016790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MPAN_016810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MPAN_016840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPAN_016930	COG0251	oxidation-reduction process
MPAN_016960	COG0765	amino acid transport
MPAN_016970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MPAN_016980	COG4496	protein, YerC YecD
MPAN_016990	COG1764	response to oxidative stress
MPAN_017000	COG1199	ATP-dependent helicase activity
MPAN_017000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MPAN_017040	COG1024	Enoyl-CoA hydratase
MPAN_017050	COG5001	Diguanylate cyclase
MPAN_017070	COG0363	glucosamine-6-phosphate deaminase activity
MPAN_017090	COG2971	BadF BadG BcrA BcrD
MPAN_017100	COG1472	Belongs to the glycosyl hydrolase 3 family
MPAN_017110	COG3876	Protein conserved in bacteria
MPAN_017130	COG0395	ABC-type sugar transport system, permease component
MPAN_017140	COG1175	transmembrane transport
MPAN_017180	COG0395	ABC-type sugar transport system, permease component
MPAN_017230	COG3409	Peptidoglycan-binding domain 1 protein
MPAN_017230	COG5632	N-Acetylmuramoyl-L-alanine amidase
MPAN_017240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MPAN_017250	COG1649	PFAM Uncharacterised BCR, COG1649
MPAN_017260	COG1649	PFAM Uncharacterised BCR, COG1649
MPAN_017270	COG1486	melibiose metabolic process
MPAN_017300	COG0277	FAD linked oxidase domain protein
MPAN_017310	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MPAN_017320	COG2086	electron transfer activity
MPAN_017370	COG2081	HI0933 family
MPAN_017420	COG0504	CTP synthase activity
MPAN_017460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MPAN_017470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MPAN_017480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MPAN_017490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MPAN_017500	COG1285	pathogenesis
MPAN_017510	COG0037	tRNA processing
MPAN_017520	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MPAN_017530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MPAN_017580	COG1653	transport
MPAN_017600	COG1175	transmembrane transport
MPAN_017610	COG3842	ATPase activity
MPAN_017630	COG0017	Asparaginyl-tRNA synthetase
MPAN_017650	COG1322	Protein conserved in bacteria
MPAN_017740	COG0187	DNA topoisomerase II activity
MPAN_017750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MPAN_017760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MPAN_017790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome