locus-tag	class	description
HLG70_00035	COG0583	DNA-binding transcription factor activity
HLG70_00050	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG70_00060	COG0477	Major facilitator Superfamily
HLG70_00070	COG0154	amidase activity
HLG70_00085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HLG70_00100	COG0495	leucyl-tRNA aminoacylation
HLG70_00105	COG2814	Major facilitator Superfamily
HLG70_00110	COG1846	Transcriptional regulator
HLG70_00120	COG1686	Belongs to the peptidase S11 family
HLG70_00150	COG0583	DNA-binding transcription factor activity
HLG70_00160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLG70_00165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HLG70_00170	COG2814	Major facilitator Superfamily
HLG70_00175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLG70_00185	COG4176	ABC-type proline glycine betaine transport system permease component
HLG70_00215	COG0583	DNA-binding transcription factor activity
HLG70_00230	COG1408	metallophosphoesterase
HLG70_00245	COG1595	DNA-templated transcription, initiation
HLG70_00250	COG3712	iron ion homeostasis
HLG70_00255	COG4774	siderophore transport
HLG70_00285	COG1793	dna ligase
HLG70_00285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HLG70_00290	COG1793	dna ligase
HLG70_00295	COG1201	RNA secondary structure unwinding
HLG70_00315	COG0469	pyruvate kinase activity
HLG70_00320	COG2271	Major facilitator Superfamily
HLG70_00325	COG0148	phosphopyruvate hydratase activity
HLG70_00370	COG1024	Enoyl-CoA hydratase
HLG70_00390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_00400	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HLG70_00405	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_00450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_00455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_00470	COG1802	Transcriptional regulator
HLG70_00500	COG1024	Enoyl-CoA hydratase
HLG70_00500	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG70_00520	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HLG70_00525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_00530	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_00555	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_00570	COG1396	sequence-specific DNA binding
HLG70_00640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLG70_00660	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HLG70_00665	COG1116	anion transmembrane transporter activity
HLG70_00670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG70_00675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLG70_00675	COG1116	anion transmembrane transporter activity
HLG70_00680	COG2197	response regulator
HLG70_00685	COG3851	Histidine kinase
HLG70_00705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG70_00710	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_00715	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLG70_00725	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HLG70_00735	COG1012	belongs to the aldehyde dehydrogenase family
HLG70_00740	COG1126	abc transporter atp-binding protein
HLG70_00755	COG0765	amino acid transport
HLG70_00760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLG70_00810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLG70_00815	COG0583	DNA-binding transcription factor activity
HLG70_00830	COG0747	negative chemotaxis
HLG70_00835	COG0601	transmembrane transport
HLG70_00840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_00845	COG4172	Belongs to the ABC transporter superfamily
HLG70_00865	COG2885	chlorophyll binding
HLG70_00870	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLG70_00885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG70_00895	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HLG70_00915	COG1802	Transcriptional regulator
HLG70_00935	COG2084	Dehydrogenase
HLG70_00945	COG0183	Belongs to the thiolase family
HLG70_00955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLG70_00960	COG1960	acyl-CoA dehydrogenase activity
HLG70_00965	COG1024	Enoyl-CoA hydratase
HLG70_00965	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG70_00990	COG1024	Enoyl-CoA hydratase
HLG70_01000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLG70_01045	COG0628	permease
HLG70_01065	COG0490	domain, Protein
HLG70_01065	COG0471	metal ion transport
HLG70_01075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLG70_01085	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HLG70_01105	COG2808	Putative FMN-binding domain
HLG70_01140	COG2321	neutral zinc metallopeptidase
HLG70_01145	COG0009	L-threonylcarbamoyladenylate synthase
HLG70_01150	COG1994	Peptidase M50
HLG70_01155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG70_01160	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HLG70_01170	COG2850	peptidyl-arginine hydroxylation
HLG70_01175	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HLG70_01185	COG0583	DNA-binding transcription factor activity
HLG70_01205	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_01210	COG0583	DNA-binding transcription factor activity
HLG70_01220	COG3360	Dodecin
HLG70_01230	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_01265	COG1802	Transcriptional regulator
HLG70_01285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG70_01290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLG70_01345	COG0668	transmembrane transport
HLG70_01365	COG0483	inositol monophosphate 1-phosphatase activity
HLG70_01380	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HLG70_01395	COG4263	nitrous-oxide reductase activity
HLG70_01410	COG1253	flavin adenine dinucleotide binding
HLG70_01415	COG1968	undecaprenyl-diphosphatase activity
HLG70_01420	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLG70_01435	COG0215	cysteine-tRNA ligase activity
HLG70_01445	COG0825	malonyl-CoA metabolic process
HLG70_01450	COG0037	tRNA processing
HLG70_01455	COG0527	aspartate kinase activity
HLG70_01475	COG2188	Transcriptional regulator
HLG70_01480	COG0154	amidase activity
HLG70_01510	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HLG70_01560	COG0583	DNA-binding transcription factor activity
HLG70_01575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HLG70_01585	COG1414	Transcriptional regulator
HLG70_01590	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_01610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLG70_01615	COG0318	PFAM AMP-dependent synthetase and ligase
HLG70_01625	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLG70_01630	COG2186	Transcriptional regulator
HLG70_01645	COG1764	response to oxidative stress
HLG70_01650	COG0583	DNA-binding transcription factor activity
HLG70_01660	COG1595	DNA-templated transcription, initiation
HLG70_01685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HLG70_01690	COG3395	kinase activity
HLG70_01700	COG4774	siderophore transport
HLG70_01705	COG0318	PFAM AMP-dependent synthetase and ligase
HLG70_01720	COG0183	Belongs to the thiolase family
HLG70_01725	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG70_01725	COG1024	Enoyl-CoA hydratase
HLG70_01735	COG1024	Enoyl-CoA hydratase
HLG70_01735	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG70_01760	COG2197	response regulator
HLG70_01765	COG2197	response regulator
HLG70_01770	COG0297	glycogen (starch) synthase activity
HLG70_01775	COG0110	maltose O-acetyltransferase activity
HLG70_01805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLG70_01825	COG1051	belongs to the nudix hydrolase family
HLG70_01840	COG0489	protein tyrosine kinase activity
HLG70_01840	COG3206	protein involved in exopolysaccharide biosynthesis
HLG70_01850	COG0166	Belongs to the GPI family
HLG70_01855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLG70_01860	COG1045	serine acetyltransferase
HLG70_01865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HLG70_01870	COG0483	inositol monophosphate 1-phosphatase activity
HLG70_01880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLG70_01900	COG0598	Magnesium transport protein CorA
HLG70_01915	COG0601	transmembrane transport
HLG70_01920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_01925	COG4172	Belongs to the ABC transporter superfamily
HLG70_01935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HLG70_01950	COG3384	dioxygenase
HLG70_01955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLG70_01965	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_02020	COG0517	IMP dehydrogenase activity
HLG70_02025	COG0583	DNA-binding transcription factor activity
HLG70_02040	COG1960	acyl-CoA dehydrogenase activity
HLG70_02045	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_02050	COG1024	Enoyl-CoA hydratase
HLG70_02055	COG0183	Belongs to the thiolase family
HLG70_02080	COG1960	acyl-CoA dehydrogenase activity
HLG70_02095	COG1802	Transcriptional regulator
HLG70_02105	COG1024	Enoyl-CoA hydratase
HLG70_02110	COG0318	PFAM AMP-dependent synthetase and ligase
HLG70_02120	COG0667	Aldo Keto reductase
HLG70_02130	COG4120	Belongs to the binding-protein-dependent transport system permease family
HLG70_02135	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HLG70_02145	COG1126	abc transporter atp-binding protein
HLG70_02150	COG0765	amino acid transport
HLG70_02160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLG70_02165	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HLG70_02165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLG70_02170	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HLG70_02195	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HLG70_02200	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLG70_02205	COG4149	molybdate abc transporter
HLG70_02210	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HLG70_02235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG70_02240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLG70_02250	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HLG70_02255	COG0736	holo-[acyl-carrier-protein] synthase activity
HLG70_02270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLG70_02280	COG1858	cytochrome C peroxidase
HLG70_02285	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HLG70_02285	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HLG70_02290	COG2224	Isocitrate lyase
HLG70_02295	COG1064	alcohol dehydrogenase
HLG70_02300	COG0583	DNA-binding transcription factor activity
HLG70_02305	COG0583	DNA-binding transcription factor activity
HLG70_02310	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_02315	COG2301	Belongs to the HpcH HpaI aldolase family
HLG70_02325	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HLG70_02325	COG4106	trans-aconitate 2-methyltransferase activity
HLG70_02335	COG0156	8-amino-7-oxononanoate synthase activity
HLG70_02355	COG3278	Belongs to the heme-copper respiratory oxidase family
HLG70_02375	COG0348	domain, Protein
HLG70_02390	COG2824	Alkylphosphonate utilization operon protein PhnA
HLG70_02400	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_02410	COG4948	Mandelate Racemase Muconate Lactonizing
HLG70_02420	COG1131	(ABC) transporter
HLG70_02425	COG0842	Transport permease protein
HLG70_02450	COG1272	protein, Hemolysin III
HLG70_02480	COG2169	Transcriptional regulator
HLG70_02490	COG0840	transmembrane signaling receptor activity
HLG70_02545	COG0747	negative chemotaxis
HLG70_02550	COG0601	transmembrane transport
HLG70_02555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_02560	COG4608	Belongs to the ABC transporter superfamily
HLG70_02565	COG0444	Belongs to the ABC transporter superfamily
HLG70_02580	COG1464	Belongs to the NlpA lipoprotein family
HLG70_02590	COG2011	ABC-type metal ion transport system permease component
HLG70_02650	COG0023	Translation Initiation Factor
HLG70_02680	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_02700	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HLG70_02705	COG3153	acetyltransferase
HLG70_02715	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_02720	COG1473	amidohydrolase
HLG70_02730	COG1309	transcriptional regulator
HLG70_02735	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_02740	COG2272	Belongs to the type-B carboxylesterase lipase family
HLG70_02750	COG0583	DNA-binding transcription factor activity
HLG70_02770	COG2951	lytic endotransglycosylase activity
HLG70_02780	COG0519	Catalyzes the synthesis of GMP from XMP
HLG70_02800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_02825	COG0488	(ABC) transporter
HLG70_02830	COG1196	nuclear chromosome segregation
HLG70_02830	COG0739	heme binding
HLG70_02830	COG0741	lytic transglycosylase activity
HLG70_02845	COG1522	sequence-specific DNA binding
HLG70_02900	COG3530	Putative quorum-sensing-regulated virulence factor
HLG70_02910	COG0443	Heat shock 70 kDa protein
HLG70_02915	COG0494	nUDIX hydrolase
HLG70_02950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLG70_02960	COG0542	response to heat
HLG70_02975	COG5441	Belongs to the UPF0261 family
HLG70_02980	COG5564	TIM-barrel signal transduction protein
HLG70_02990	COG0583	DNA-binding transcription factor activity
HLG70_02995	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HLG70_03010	COG1477	protein flavinylation
HLG70_03035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HLG70_03040	COG2188	Transcriptional regulator
HLG70_03050	COG0583	DNA-binding transcription factor activity
HLG70_03075	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLG70_03085	COG1562	ergosterol biosynthetic process
HLG70_03090	COG1562	ergosterol biosynthetic process
HLG70_03095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLG70_03100	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_03110	COG3971	2-oxopent-4-enoate hydratase activity
HLG70_03125	COG1012	belongs to the aldehyde dehydrogenase family
HLG70_03130	COG3384	dioxygenase
HLG70_03160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLG70_03165	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_03170	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_03180	COG2186	Transcriptional regulator
HLG70_03195	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_03210	COG0583	DNA-binding transcription factor activity
HLG70_03215	COG0268	Binds directly to 16S ribosomal RNA
HLG70_03225	COG0728	peptidoglycan biosynthetic process
HLG70_03235	COG0563	adenylate kinase activity
HLG70_03240	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HLG70_03245	COG2835	tetraacyldisaccharide 4'-kinase activity
HLG70_03250	COG1663	tetraacyldisaccharide 4'-kinase activity
HLG70_03260	COG0811	peptide transport
HLG70_03275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLG70_03285	COG0038	chloride channel
HLG70_03290	COG0183	Belongs to the thiolase family
HLG70_03300	COG1278	Cold shock
HLG70_03305	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HLG70_03310	COG2373	Large extracellular alpha-helical protein
HLG70_03315	COG4953	penicillin-binding protein 1C
HLG70_03320	COG0542	response to heat
HLG70_03325	COG2995	paraquat-inducible protein a
HLG70_03330	COG3008	intermembrane lipid transfer
HLG70_03340	COG0506	proline dehydrogenase activity
HLG70_03340	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HLG70_03340	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HLG70_03350	COG0559	Belongs to the binding-protein-dependent transport system permease family
HLG70_03370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_03375	COG1024	Enoyl-CoA hydratase
HLG70_03385	COG1802	Transcriptional regulator
HLG70_03390	COG2271	Major facilitator Superfamily
HLG70_03405	COG1914	H( )-stimulated, divalent metal cation uptake system
HLG70_03410	COG1764	response to oxidative stress
HLG70_03420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_03425	COG0765	amino acid transport
HLG70_03430	COG0765	amino acid transport
HLG70_03435	COG1126	abc transporter atp-binding protein
HLG70_03440	COG1902	pentaerythritol trinitrate reductase activity
HLG70_03490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLG70_03495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HLG70_03500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLG70_03505	COG0196	riboflavin kinase activity
HLG70_03510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLG70_03515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLG70_03515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLG70_03530	COG0210	DNA helicase
HLG70_03545	COG4771	TonB-dependent receptor
HLG70_03560	COG0488	(ABC) transporter
HLG70_03565	COG2890	protein-(glutamine-N5) methyltransferase activity
HLG70_03575	COG2171	N-acyltransferase activity
HLG70_03580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLG70_03590	COG2755	lipolytic protein G-D-S-L family
HLG70_03590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HLG70_03605	COG2271	Major facilitator Superfamily
HLG70_03610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HLG70_03615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HLG70_03620	COG0277	FAD linked oxidase domain protein
HLG70_03645	COG3038	cytochrome b561
HLG70_03650	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HLG70_03665	COG3008	intermembrane lipid transfer
HLG70_03685	COG1309	transcriptional regulator
HLG70_03700	COG0583	DNA-binding transcription factor activity
HLG70_03710	COG0251	oxidation-reduction process
HLG70_03740	COG1278	Cold shock
HLG70_03750	COG1278	Cold shock
HLG70_03760	COG0501	Belongs to the peptidase M48B family
HLG70_03765	COG0544	peptidyl-prolyl cis-trans isomerase activity
HLG70_03770	COG0740	serine-type endopeptidase activity
HLG70_03775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HLG70_03780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLG70_03785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLG70_03795	COG0556	nucleotide-excision repair
HLG70_03800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLG70_03810	COG1104	cysteine desulfurase activity
HLG70_03815	COG0822	iron-sulfur transferase activity
HLG70_03825	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HLG70_03830	COG0443	Heat shock 70 kDa protein
HLG70_03845	COG1803	Methylglyoxal synthase
HLG70_03850	COG1024	Enoyl-CoA hydratase
HLG70_03880	COG1022	Amp-dependent synthetase and ligase
HLG70_03885	COG0183	Belongs to the thiolase family
HLG70_03890	COG1309	transcriptional regulator
HLG70_03900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HLG70_03905	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_03915	COG2271	Major facilitator Superfamily
HLG70_03935	COG1136	(ABC) transporter
HLG70_03945	COG4771	TonB-dependent receptor
HLG70_03955	COG0745	RESPONSE REGULATOR receiver
HLG70_03960	COG4771	TonB-dependent receptor
HLG70_03965	COG4607	ABC-type enterochelin transport system periplasmic component
HLG70_03970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG70_03975	COG4605	iron ion homeostasis
HLG70_03980	COG4604	ABC transporter, ATP-binding protein
HLG70_03985	COG0737	Belongs to the 5'-nucleotidase family
HLG70_04005	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HLG70_04040	COG0583	DNA-binding transcription factor activity
HLG70_04050	COG0473	3-isopropylmalate dehydrogenase activity
HLG70_04065	COG1850	ribulose-bisphosphate carboxylase activity
HLG70_04075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HLG70_04080	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLG70_04115	COG2197	response regulator
HLG70_04120	COG3851	Histidine kinase
HLG70_04125	COG1846	Transcriptional regulator
HLG70_04135	COG1566	PFAM secretion protein HlyD family protein
HLG70_04145	COG3707	response regulator
HLG70_04160	COG2116	formate transmembrane transporter activity
HLG70_04165	COG2146	nitrite reductase [NAD(P)H] activity
HLG70_04170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLG70_04170	COG2146	nitrite reductase [NAD(P)H] activity
HLG70_04175	COG0583	DNA-binding transcription factor activity
HLG70_04180	COG4804	nuclease activity
HLG70_04190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLG70_04200	COG0613	PHP domain protein
HLG70_04210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLG70_04215	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HLG70_04215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HLG70_04225	COG0047	phosphoribosylformylglycinamidine synthase activity
HLG70_04225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLG70_04230	COG0583	DNA-binding transcription factor activity
HLG70_04250	COG1012	belongs to the aldehyde dehydrogenase family
HLG70_04255	COG2084	Dehydrogenase
HLG70_04265	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_04290	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_04310	COG2353	YceI-like domain
HLG70_04335	COG1309	transcriptional regulator
HLG70_04360	COG2207	Transcriptional regulator
HLG70_04360	COG3708	Transcriptional regulator
HLG70_04365	COG1335	isochorismatase
HLG70_04415	COG0583	DNA-binding transcription factor activity
HLG70_04420	COG2130	NADP-dependent
HLG70_04480	COG0747	negative chemotaxis
HLG70_04485	COG4608	Belongs to the ABC transporter superfamily
HLG70_04495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_04500	COG0601	transmembrane transport
HLG70_04505	COG2072	flavoprotein involved in K transport
HLG70_04535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLG70_04545	COG0583	DNA-binding transcription factor activity
HLG70_04610	COG0519	Catalyzes the synthesis of GMP from XMP
HLG70_04610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLG70_04620	COG0640	Transcriptional regulator
HLG70_04630	COG3550	peptidyl-serine autophosphorylation
HLG70_04635	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HLG70_04640	COG1522	sequence-specific DNA binding
HLG70_04650	COG0436	Aminotransferase
HLG70_04685	COG0667	Aldo Keto reductase
HLG70_04690	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLG70_04710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HLG70_04715	COG2188	Transcriptional regulator
HLG70_04745	COG1199	ATP-dependent helicase activity
HLG70_04760	COG0583	DNA-binding transcription factor activity
HLG70_04765	COG0154	amidase activity
HLG70_04770	COG0840	transmembrane signaling receptor activity
HLG70_04795	COG2201	protein-glutamate methylesterase activity
HLG70_04800	COG2203	Gaf domain
HLG70_04800	COG3706	GGDEF domain
HLG70_04800	COG4251	negative regulation of phosphorylation
HLG70_04800	COG5001	Diguanylate cyclase
HLG70_04805	COG1522	sequence-specific DNA binding
HLG70_04850	COG0318	PFAM AMP-dependent synthetase and ligase
HLG70_04855	COG1960	acyl-CoA dehydrogenase activity
HLG70_04860	COG1960	acyl-CoA dehydrogenase activity
HLG70_04865	COG0183	Belongs to the thiolase family
HLG70_04875	COG0583	DNA-binding transcription factor activity
HLG70_04880	COG0628	permease
HLG70_04890	COG2733	membrane
HLG70_04900	COG0625	glutathione transferase activity
HLG70_04930	COG1864	DNA RNA non-specific endonuclease
HLG70_04930	COG3591	Belongs to the peptidase S1B family
HLG70_04960	COG2885	chlorophyll binding
HLG70_05015	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HLG70_05025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HLG70_05040	COG1846	Transcriptional regulator
HLG70_05050	COG3541	Predicted nucleotidyltransferase
HLG70_05055	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_05060	COG0583	DNA-binding transcription factor activity
HLG70_05085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLG70_05090	COG0697	spore germination
HLG70_05100	COG4941	Belongs to the sigma-70 factor family
HLG70_05110	COG3795	YCII-related domain
HLG70_05120	COG3795	YCII-related domain
HLG70_05135	COG3047	cAMP biosynthetic process
HLG70_05135	COG2885	chlorophyll binding
HLG70_05155	COG2207	Transcriptional regulator
HLG70_05165	COG1683	Conserved Protein
HLG70_05175	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_05185	COG1309	transcriptional regulator
HLG70_05195	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_05200	COG0668	transmembrane transport
HLG70_05210	COG4608	Belongs to the ABC transporter superfamily
HLG70_05215	COG0444	Belongs to the ABC transporter superfamily
HLG70_05220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_05230	COG0747	negative chemotaxis
HLG70_05235	COG1802	Transcriptional regulator
HLG70_05240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLG70_05265	COG0667	Aldo Keto reductase
HLG70_05275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG70_05280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLG70_05300	COG1414	Transcriptional regulator
HLG70_05305	COG3311	Transcriptional regulator
HLG70_05310	COG1569	PIN domain
HLG70_05325	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLG70_05335	COG1473	amidohydrolase
HLG70_05350	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HLG70_05400	COG2271	Major facilitator Superfamily
HLG70_05405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLG70_05420	COG0587	DNA-directed DNA polymerase activity
HLG70_05435	COG0833	amino acid
HLG70_05440	COG0400	carboxylic ester hydrolase activity
HLG70_05450	COG1566	PFAM secretion protein HlyD family protein
HLG70_05470	COG0720	synthase
HLG70_05475	COG0602	queuosine metabolic process
HLG70_05495	COG1902	pentaerythritol trinitrate reductase activity
HLG70_05525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLG70_05540	COG0842	Transport permease protein
HLG70_05545	COG1131	(ABC) transporter
HLG70_05560	COG2130	NADP-dependent
HLG70_05585	COG3842	ATPase activity
HLG70_05590	COG3842	ATPase activity
HLG70_05600	COG0395	ABC-type sugar transport system, permease component
HLG70_05625	COG2199	diguanylate cyclase activity
HLG70_05625	COG2203	Gaf domain
HLG70_05630	COG3634	alkyl hydroperoxide reductase activity
HLG70_05635	COG3387	PFAM Glycoside hydrolase 15-related
HLG70_05640	COG1960	acyl-CoA dehydrogenase activity
HLG70_05685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLG70_05690	COG0420	3'-5' exonuclease activity
HLG70_05715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLG70_05715	COG2111	Na H antiporter
HLG70_05720	COG1006	Multisubunit Na H antiporter MnhC subunit
HLG70_05725	COG0651	ATP synthesis coupled electron transport
HLG70_05730	COG1863	multisubunit Na H antiporter MnhE subunit
HLG70_05735	COG2212	antiporter activity
HLG70_05755	COG0590	tRNA wobble adenosine to inosine editing
HLG70_05760	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLG70_05765	COG0488	(ABC) transporter
HLG70_05800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLG70_05805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLG70_05815	COG2252	PERMEase
HLG70_05820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HLG70_05825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HLG70_05835	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HLG70_05865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLG70_05870	COG0789	Transcriptional regulator
HLG70_05885	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HLG70_05885	COG0678	peroxiredoxin activity
HLG70_05895	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HLG70_05900	COG0584	glycerophosphoryl diester phosphodiesterase
HLG70_05910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLG70_05920	COG4181	ATPase activity
HLG70_05930	COG1178	ABC-type Fe3 transport system permease component
HLG70_05935	COG3842	ATPase activity
HLG70_05940	COG0583	DNA-binding transcription factor activity
HLG70_05945	COG0560	Phosphoserine phosphatase
HLG70_05955	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HLG70_05965	COG0583	DNA-binding transcription factor activity
HLG70_05980	COG0583	DNA-binding transcription factor activity
HLG70_05985	COG4336	lyase activity
HLG70_06020	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLG70_06060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_06065	COG0765	amino acid transport
HLG70_06070	COG1126	abc transporter atp-binding protein
HLG70_06075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLG70_06080	COG1758	RNA polymerase activity
HLG70_06085	COG0194	GDP metabolic process
HLG70_06090	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_06095	COG0791	NLP P60 protein
HLG70_06100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLG70_06105	COG0833	amino acid
HLG70_06110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLG70_06115	COG0583	DNA-binding transcription factor activity
HLG70_06120	COG1942	4-Oxalocrotonate Tautomerase
HLG70_06125	COG1561	YicC-like family, N-terminal region
HLG70_06130	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HLG70_06135	COG1012	belongs to the aldehyde dehydrogenase family
HLG70_06160	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_06165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLG70_06180	COG1960	acyl-CoA dehydrogenase activity
HLG70_06190	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HLG70_06195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HLG70_06200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLG70_06205	COG0174	glutamine synthetase
HLG70_06215	COG2204	response regulator
HLG70_06220	COG0583	DNA-binding transcription factor activity
HLG70_06225	COG1741	Belongs to the pirin family
HLG70_06230	COG1741	Belongs to the pirin family
HLG70_06245	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_06250	COG3842	ATPase activity
HLG70_06260	COG1840	ABC-type Fe3 transport system, periplasmic component
HLG70_06305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLG70_06310	COG0583	DNA-binding transcription factor activity
HLG70_06315	COG0783	Belongs to the Dps family
HLG70_06330	COG1215	transferase activity, transferring glycosyl groups
HLG70_06350	COG0438	transferase activity, transferring glycosyl groups
HLG70_06360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HLG70_06385	COG0156	8-amino-7-oxononanoate synthase activity
HLG70_06390	COG0604	alcohol dehydrogenase
HLG70_06390	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_06390	COG3321	synthase
HLG70_06405	COG3842	ATPase activity
HLG70_06410	COG0395	ABC-type sugar transport system, permease component
HLG70_06415	COG1175	transmembrane transport
HLG70_06420	COG1653	transport
HLG70_06430	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HLG70_06440	COG0559	Belongs to the binding-protein-dependent transport system permease family
HLG70_06460	COG1794	racemase activity, acting on amino acids and derivatives
HLG70_06465	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HLG70_06475	COG0583	DNA-binding transcription factor activity
HLG70_06480	COG0625	glutathione transferase activity
HLG70_06485	COG2133	pyrroloquinoline quinone binding
HLG70_06495	COG0697	spore germination
HLG70_06500	COG2363	Small membrane protein
HLG70_06530	COG0010	Belongs to the arginase family
HLG70_06535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLG70_06540	COG1464	Belongs to the NlpA lipoprotein family
HLG70_06555	COG1408	metallophosphoesterase
HLG70_06565	COG0688	phosphatidylethanolamine metabolic process
HLG70_06570	COG0488	(ABC) transporter
HLG70_06595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLG70_06600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLG70_06605	COG3300	MHYT domain
HLG70_06605	COG5001	Diguanylate cyclase
HLG70_06625	COG2814	Major facilitator Superfamily
HLG70_06645	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HLG70_06650	COG2204	response regulator
HLG70_06655	COG2204	response regulator
HLG70_06680	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_06720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLG70_06725	COG0589	response to stress
HLG70_06730	COG1289	transmembrane transporter activity
HLG70_06735	COG2199	diguanylate cyclase activity
HLG70_06735	COG2200	EAL domain
HLG70_06750	COG1640	4-alpha-glucanotransferase
HLG70_06755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HLG70_06765	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HLG70_06770	COG0366	Alpha amylase catalytic
HLG70_06775	COG0366	Alpha amylase catalytic
HLG70_06780	COG0297	glycogen (starch) synthase activity
HLG70_06785	COG0028	Belongs to the TPP enzyme family
HLG70_06830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLG70_06835	COG3568	Endonuclease Exonuclease Phosphatase
HLG70_06850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_06855	COG4172	Belongs to the ABC transporter superfamily
HLG70_06905	COG1253	flavin adenine dinucleotide binding
HLG70_06920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HLG70_06925	COG0714	Associated with various cellular activities
HLG70_06945	COG2304	oxidoreductase activity
HLG70_06960	COG3119	arylsulfatase activity
HLG70_07005	COG1024	Enoyl-CoA hydratase
HLG70_07010	COG2814	Major facilitator Superfamily
HLG70_07030	COG2807	transmembrane transport
HLG70_07035	COG1846	Transcriptional regulator
HLG70_07050	COG4774	siderophore transport
HLG70_07055	COG3712	iron ion homeostasis
HLG70_07070	COG2199	diguanylate cyclase activity
HLG70_07075	COG3706	GGDEF domain
HLG70_07095	COG2197	response regulator
HLG70_07105	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HLG70_07110	COG0784	Response regulator, receiver
HLG70_07110	COG2205	protein histidine kinase activity
HLG70_07125	COG0628	permease
HLG70_07150	COG1959	2 iron, 2 sulfur cluster binding
HLG70_07160	COG0531	amino acid
HLG70_07180	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HLG70_07200	COG4772	TonB-dependent receptor
HLG70_07220	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HLG70_07225	COG3119	arylsulfatase activity
HLG70_07230	COG0431	NADPH-dependent FMN reductase
HLG70_07240	COG0798	PFAM Bile acid sodium symporter
HLG70_07270	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_07290	COG1024	Enoyl-CoA hydratase
HLG70_07295	COG2079	MmgE PrpD family protein
HLG70_07310	COG1414	Transcriptional regulator
HLG70_07345	COG1073	alpha beta
HLG70_07365	COG1696	Membrane protein involved in D-alanine export
HLG70_07400	COG1215	transferase activity, transferring glycosyl groups
HLG70_07410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HLG70_07430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLG70_07445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLG70_07455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLG70_07460	COG0581	inorganic phosphate transmembrane transporter activity
HLG70_07465	COG0573	inorganic phosphate transmembrane transporter activity
HLG70_07470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLG70_07485	COG2072	flavoprotein involved in K transport
HLG70_07500	COG0431	NADPH-dependent FMN reductase
HLG70_07515	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HLG70_07530	COG4191	Histidine kinase
HLG70_07550	COG4654	Cytochrome c, class I
HLG70_07555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLG70_07630	COG3210	domain, Protein
HLG70_07650	COG3210	domain, Protein
HLG70_07705	COG2831	hemolysin activation secretion protein
HLG70_07725	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HLG70_07750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLG70_07760	COG2084	Dehydrogenase
HLG70_07790	COG3111	PFAM Bacterial OB fold (BOF) protein
HLG70_07800	COG0583	DNA-binding transcription factor activity
HLG70_07805	COG0583	DNA-binding transcription factor activity
HLG70_07815	COG5001	Diguanylate cyclase
HLG70_07815	COG3300	MHYT domain
HLG70_07820	COG3706	GGDEF domain
HLG70_07840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLG70_07915	COG0702	epimerase
HLG70_07925	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_07930	COG2721	sulfolactate sulfo-lyase activity
HLG70_07955	COG1335	isochorismatase
HLG70_07990	COG0166	Belongs to the GPI family
HLG70_07995	COG3459	Glycosyltransferase 36 associated
HLG70_08010	COG4774	siderophore transport
HLG70_08015	COG2186	Transcriptional regulator
HLG70_08020	COG0747	negative chemotaxis
HLG70_08030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_08035	COG0444	Belongs to the ABC transporter superfamily
HLG70_08050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLG70_08060	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HLG70_08060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HLG70_08070	COG0028	Belongs to the TPP enzyme family
HLG70_08080	COG1012	belongs to the aldehyde dehydrogenase family
HLG70_08100	COG0583	DNA-binding transcription factor activity
HLG70_08115	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_08120	COG3386	PFAM SMP-30 Gluconolaconase
HLG70_08125	COG2721	sulfolactate sulfo-lyase activity
HLG70_08130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG70_08150	COG3321	synthase
HLG70_08150	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_08150	COG0604	alcohol dehydrogenase
HLG70_08165	COG0601	transmembrane transport
HLG70_08170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_08175	COG0318	PFAM AMP-dependent synthetase and ligase
HLG70_08190	COG1116	anion transmembrane transporter activity
HLG70_08195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG70_08215	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLG70_08230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLG70_08245	COG0390	transport system, permease component
HLG70_08255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG70_08265	COG1538	Outer membrane efflux protein
HLG70_08275	COG1126	abc transporter atp-binding protein
HLG70_08280	COG0765	amino acid transport
HLG70_08285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_08290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLG70_08300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HLG70_08330	COG4566	intracellular signal transduction
HLG70_08355	COG2897	thiosulfate sulfurtransferase activity
HLG70_08375	COG0583	DNA-binding transcription factor activity
HLG70_08395	COG1126	abc transporter atp-binding protein
HLG70_08405	COG0765	amino acid transport
HLG70_08415	COG0277	FAD linked oxidase domain protein
HLG70_08435	COG2175	clavaminate synthase activity
HLG70_08445	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HLG70_08475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLG70_08485	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_08520	COG1335	isochorismatase
HLG70_08550	COG2207	Transcriptional regulator
HLG70_08555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLG70_08560	COG3608	succinylglutamate desuccinylase aspartoacylase
HLG70_08575	COG1414	Transcriptional regulator
HLG70_08585	COG2814	Major facilitator Superfamily
HLG70_08595	COG0784	Response regulator, receiver
HLG70_08595	COG4191	Histidine kinase
HLG70_08655	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_08670	COG0583	DNA-binding transcription factor activity
HLG70_08675	COG0277	FAD linked oxidase domain protein
HLG70_08675	COG0247	lactate metabolic process
HLG70_08680	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_08685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG70_08695	COG3706	GGDEF domain
HLG70_08710	COG1335	isochorismatase
HLG70_08720	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_08725	COG0477	Major facilitator Superfamily
HLG70_08730	COG0251	oxidation-reduction process
HLG70_08740	COG1960	acyl-CoA dehydrogenase activity
HLG70_08785	COG0583	DNA-binding transcription factor activity
HLG70_08800	COG4948	Mandelate Racemase Muconate Lactonizing
HLG70_08820	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLG70_08825	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HLG70_08850	COG2010	Cytochrome c
HLG70_08860	COG0737	Belongs to the 5'-nucleotidase family
HLG70_08875	COG0300	oxidoreductase activity
HLG70_08880	COG2207	Transcriptional regulator
HLG70_08900	COG2382	esterase
HLG70_08955	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HLG70_08965	COG0251	oxidation-reduction process
HLG70_08980	COG0346	lactoylglutathione lyase activity
HLG70_08985	COG1802	Transcriptional regulator
HLG70_08990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG70_08995	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_09005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLG70_09040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_09045	COG4597	amino acid ABC transporter
HLG70_09050	COG3154	lipid carrier protein
HLG70_09055	COG0826	peptidase U32
HLG70_09060	COG0826	peptidase U32
HLG70_09065	COG2197	response regulator
HLG70_09070	COG3850	Histidine kinase
HLG70_09075	COG1763	Mo-molybdopterin cofactor biosynthetic process
HLG70_09080	COG0288	reversible hydration of carbon dioxide
HLG70_09085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLG70_09090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLG70_09095	COG2181	nitrate reductase activity
HLG70_09100	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HLG70_09105	COG1140	nitrate reductase beta subunit
HLG70_09110	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HLG70_09115	COG2223	nitrite transmembrane transporter activity
HLG70_09145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLG70_09160	COG1538	Outer membrane efflux protein
HLG70_09165	COG1566	PFAM secretion protein HlyD family protein
HLG70_09200	COG1328	CTP reductase activity
HLG70_09215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG70_09235	COG2070	2-Nitropropane dioxygenase
HLG70_09245	COG3848	Pyruvate phosphate dikinase
HLG70_09245	COG0574	Belongs to the PEP-utilizing enzyme family
HLG70_09250	COG5002	protein histidine kinase activity
HLG70_09255	COG0745	RESPONSE REGULATOR receiver
HLG70_09260	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HLG70_09265	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HLG70_09275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLG70_09280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLG70_09335	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HLG70_09355	COG0625	glutathione transferase activity
HLG70_09370	COG2226	methyltransferase
HLG70_09380	COG1401	restriction endodeoxyribonuclease activity
HLG70_09400	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLG70_09430	COG3386	PFAM SMP-30 Gluconolaconase
HLG70_09445	COG0583	DNA-binding transcription factor activity
HLG70_09485	COG5001	Diguanylate cyclase
HLG70_09485	COG4251	negative regulation of phosphorylation
HLG70_09485	COG3706	GGDEF domain
HLG70_09485	COG2203	Gaf domain
HLG70_09495	COG0583	DNA-binding transcription factor activity
HLG70_09500	COG0604	alcohol dehydrogenase
HLG70_09510	COG0640	Transcriptional regulator
HLG70_09520	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HLG70_09530	COG1414	Transcriptional regulator
HLG70_09535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLG70_09540	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HLG70_09545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HLG70_09550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HLG70_09555	COG3485	protocatechuate 3,4-dioxygenase
HLG70_09560	COG3485	protocatechuate 3,4-dioxygenase
HLG70_09565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLG70_09570	COG0783	Belongs to the Dps family
HLG70_09580	COG2879	small protein
HLG70_09585	COG1966	Carbon starvation protein
HLG70_09605	COG4521	taurine ABC transporter
HLG70_09610	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HLG70_09615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG70_09635	COG0523	cobalamin synthesis protein
HLG70_09655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_09660	COG0601	transmembrane transport
HLG70_09665	COG0747	negative chemotaxis
HLG70_09680	COG1414	Transcriptional regulator
HLG70_09685	COG0513	Belongs to the DEAD box helicase family
HLG70_09710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_09715	COG0415	Belongs to the DNA photolyase family
HLG70_09720	COG0840	transmembrane signaling receptor activity
HLG70_09740	COG0386	Belongs to the glutathione peroxidase family
HLG70_09745	COG1522	sequence-specific DNA binding
HLG70_09755	COG0625	glutathione transferase activity
HLG70_09770	COG0095	Lipoate-protein ligase
HLG70_09780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLG70_09785	COG0010	Belongs to the arginase family
HLG70_09790	COG1126	abc transporter atp-binding protein
HLG70_09795	COG0765	amino acid transport
HLG70_09800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_09815	COG0084	hydrolase, TatD family'
HLG70_09820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLG70_09825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HLG70_09830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLG70_09855	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HLG70_09860	COG1960	acyl-CoA dehydrogenase activity
HLG70_09870	COG2867	negative regulation of translational initiation
HLG70_09875	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HLG70_09895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLG70_09895	COG0519	Catalyzes the synthesis of GMP from XMP
HLG70_09900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLG70_09900	COG2169	Transcriptional regulator
HLG70_09920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLG70_09925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HLG70_09940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HLG70_09945	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLG70_09950	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HLG70_09955	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLG70_09960	COG0750	zinc metalloprotease
HLG70_09965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HLG70_09970	COG0575	Belongs to the CDS family
HLG70_09975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLG70_09980	COG0233	cytoplasmic translational termination
HLG70_09985	COG0528	UMP kinase activity
HLG70_09990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HLG70_09995	COG0052	Belongs to the universal ribosomal protein uS2 family
HLG70_10000	COG0024	Methionine aminopeptidase
HLG70_10005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HLG70_10015	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HLG70_10020	COG1451	nucleotide metabolic process
HLG70_10030	COG1286	toxin biosynthetic process
HLG70_10040	COG0285	dihydrofolate synthase activity
HLG70_10055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_10070	COG1334	flagellar protein FlaG
HLG70_10075	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HLG70_10095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLG70_10105	COG1677	Flagellar hook-basal body complex protein FliE
HLG70_10115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLG70_10150	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLG70_10165	COG1987	bacterial-type flagellum assembly
HLG70_10175	COG0840	transmembrane signaling receptor activity
HLG70_10180	COG0840	transmembrane signaling receptor activity
HLG70_10190	COG0840	transmembrane signaling receptor activity
HLG70_10195	COG0840	transmembrane signaling receptor activity
HLG70_10205	COG1256	bacterial-type flagellum assembly
HLG70_10210	COG1705	Flagellar rod assembly protein muramidase FlgJ
HLG70_10210	COG3951	Flagellar rod assembly protein muramidase FlgJ
HLG70_10230	COG4787	bacterial-type flagellum-dependent cell motility
HLG70_10245	COG1558	bacterial-type flagellum-dependent cell motility
HLG70_10250	COG1815	bacterial-type flagellum-dependent cell motility
HLG70_10260	COG2747	anti-sigma28 factor FlgM
HLG70_10275	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLG70_10285	COG0840	transmembrane signaling receptor activity
HLG70_10290	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HLG70_10295	COG0745	RESPONSE REGULATOR receiver
HLG70_10300	COG2201	protein-glutamate methylesterase activity
HLG70_10305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLG70_10310	COG0840	transmembrane signaling receptor activity
HLG70_10315	COG0835	chemotaxis
HLG70_10325	COG0745	RESPONSE REGULATOR receiver
HLG70_10350	COG1191	sigma factor activity
HLG70_10370	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HLG70_10380	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HLG70_10425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLG70_10430	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLG70_10445	COG4566	intracellular signal transduction
HLG70_10450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HLG70_10455	COG0339	signal peptide processing
HLG70_10460	COG1999	signal sequence binding
HLG70_10465	COG2261	transglycosylase associated protein
HLG70_10485	COG0583	DNA-binding transcription factor activity
HLG70_10490	COG1187	pseudouridine synthase activity
HLG70_10495	COG3161	chorismate lyase activity
HLG70_10525	COG0066	3-isopropylmalate dehydratase activity
HLG70_10530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HLG70_10560	COG2188	Transcriptional regulator
HLG70_10595	COG4681	YaeQ
HLG70_10600	COG1280	lysine exporter protein (LysE YggA)
HLG70_10605	COG4172	Belongs to the ABC transporter superfamily
HLG70_10610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_10615	COG0601	transmembrane transport
HLG70_10620	COG0747	negative chemotaxis
HLG70_10630	COG0583	DNA-binding transcription factor activity
HLG70_10725	COG0668	transmembrane transport
HLG70_10730	COG0165	Argininosuccinate lyase
HLG70_10770	COG0022	dehydrogenase e1 component
HLG70_10815	COG1024	Enoyl-CoA hydratase
HLG70_10820	COG2186	Transcriptional regulator
HLG70_10825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_10830	COG0789	Transcriptional regulator
HLG70_10840	COG4753	response regulator
HLG70_10840	COG2207	Transcriptional regulator
HLG70_10860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLG70_10870	COG2271	Major facilitator Superfamily
HLG70_10880	COG0307	riboflavin synthase, alpha
HLG70_10885	COG1012	belongs to the aldehyde dehydrogenase family
HLG70_10905	COG0784	Response regulator, receiver
HLG70_10905	COG4191	Histidine kinase
HLG70_10910	COG2204	response regulator
HLG70_10915	COG1278	Cold shock
HLG70_10920	COG1546	Belongs to the CinA family
HLG70_10920	COG1058	Belongs to the CinA family
HLG70_10925	COG1757	Na H antiporter
HLG70_11065	COG4608	Belongs to the ABC transporter superfamily
HLG70_11070	COG0444	Belongs to the ABC transporter superfamily
HLG70_11085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLG70_11105	COG0583	DNA-binding transcription factor activity
HLG70_11110	COG0747	negative chemotaxis
HLG70_11115	COG2226	methyltransferase
HLG70_11120	COG2814	Major facilitator Superfamily
HLG70_11165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG70_11190	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_11200	COG1129	ABC transporter
HLG70_11235	COG1802	Transcriptional regulator
HLG70_11240	COG5265	(ABC) transporter
HLG70_11245	COG1280	lysine exporter protein (LysE YggA)
HLG70_11260	COG4977	sequence-specific DNA binding
HLG70_11280	COG0318	PFAM AMP-dependent synthetase and ligase
HLG70_11285	COG2188	Transcriptional regulator
HLG70_11300	COG0477	Major facilitator Superfamily
HLG70_11305	COG0235	Class ii aldolase
HLG70_11320	COG0583	DNA-binding transcription factor activity
HLG70_11330	COG2223	nitrite transmembrane transporter activity
HLG70_11345	COG2610	gluconate transmembrane transporter activity
HLG70_11350	COG0583	DNA-binding transcription factor activity
HLG70_11355	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_11360	COG1024	Enoyl-CoA hydratase
HLG70_11365	COG5001	Diguanylate cyclase
HLG70_11370	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_11375	COG0129	dihydroxy-acid dehydratase activity
HLG70_11385	COG1595	DNA-templated transcription, initiation
HLG70_11390	COG3712	iron ion homeostasis
HLG70_11400	COG0583	DNA-binding transcription factor activity
HLG70_11405	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG70_11410	COG3246	L-lysine catabolic process to acetate
HLG70_11430	COG3043	anaerobic respiration
HLG70_11435	COG3005	denitrification pathway
HLG70_11440	COG4133	protoheme IX ABC transporter activity
HLG70_11460	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HLG70_11470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLG70_11515	COG0583	DNA-binding transcription factor activity
HLG70_11520	COG0667	Aldo Keto reductase
HLG70_11530	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HLG70_11535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLG70_11545	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_11565	COG0697	spore germination
HLG70_11570	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HLG70_11575	COG0697	spore germination
HLG70_11595	COG0183	Belongs to the thiolase family
HLG70_11600	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_11605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_11615	COG0583	DNA-binding transcription factor activity
HLG70_11625	COG1280	lysine exporter protein (LysE YggA)
HLG70_11640	COG1280	lysine exporter protein (LysE YggA)
HLG70_11645	COG3245	cytochrome
HLG70_11655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLG70_11670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLG70_11680	COG0318	PFAM AMP-dependent synthetase and ligase
HLG70_11685	COG1960	acyl-CoA dehydrogenase activity
HLG70_11690	COG2814	Major facilitator Superfamily
HLG70_11705	COG0625	glutathione transferase activity
HLG70_11715	COG0583	DNA-binding transcription factor activity
HLG70_11725	COG0583	DNA-binding transcription factor activity
HLG70_11740	COG0506	proline dehydrogenase activity
HLG70_11750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLG70_11755	COG1959	2 iron, 2 sulfur cluster binding
HLG70_11765	COG1610	YqeY-like protein
HLG70_11795	COG0457	Tetratricopeptide repeat
HLG70_11800	COG0726	polysaccharide deacetylase
HLG70_11800	COG1649	PFAM Uncharacterised BCR, COG1649
HLG70_11805	COG1215	transferase activity, transferring glycosyl groups
HLG70_11815	COG2223	nitrite transmembrane transporter activity
HLG70_11830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLG70_11845	COG0656	L-ascorbic acid biosynthetic process
HLG70_11850	COG5265	(ABC) transporter
HLG70_11865	COG0583	DNA-binding transcription factor activity
HLG70_11880	COG1116	anion transmembrane transporter activity
HLG70_11905	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_11940	COG1522	sequence-specific DNA binding
HLG70_11965	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_11975	COG0456	acetyltransferase
HLG70_11980	COG0384	phenazine biosynthesis protein PhzF
HLG70_11985	COG3119	arylsulfatase activity
HLG70_12015	COG0776	regulation of translation
HLG70_12020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLG70_12020	COG0072	phenylalanine-tRNA ligase activity
HLG70_12025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HLG70_12030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HLG70_12035	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HLG70_12040	COG0606	chelatase, subunit chli
HLG70_12045	COG2960	long-chain fatty acid transporting porin activity
HLG70_12050	COG0347	Belongs to the P(II) protein family
HLG70_12055	COG0004	ammonium transporteR
HLG70_12060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLG70_12065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLG70_12080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HLG70_12085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLG70_12090	COG2197	response regulator
HLG70_12095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLG70_12115	COG1012	belongs to the aldehyde dehydrogenase family
HLG70_12125	COG0601	transmembrane transport
HLG70_12130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_12135	COG4172	Belongs to the ABC transporter superfamily
HLG70_12155	COG4774	siderophore transport
HLG70_12160	COG4607	ABC-type enterochelin transport system periplasmic component
HLG70_12165	COG4604	ABC transporter, ATP-binding protein
HLG70_12170	COG4605	iron ion homeostasis
HLG70_12175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG70_12185	COG2375	cellular response to nickel ion
HLG70_12185	COG1132	(ABC) transporter
HLG70_12195	COG1609	Transcriptional regulator
HLG70_12200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HLG70_12205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HLG70_12210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLG70_12215	COG0129	dihydroxy-acid dehydratase activity
HLG70_12240	COG0135	phosphoribosylanthranilate isomerase activity
HLG70_12245	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HLG70_12250	COG0101	tRNA pseudouridine synthase activity
HLG70_12260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLG70_12280	COG1538	Outer membrane efflux protein
HLG70_12290	COG2274	protein secretion by the type I secretion system
HLG70_12295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG70_12320	COG4783	chaperone-mediated protein folding
HLG70_12325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HLG70_12340	COG2205	protein histidine kinase activity
HLG70_12350	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HLG70_12360	COG1295	ribonuclease BN
HLG70_12370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLG70_12400	COG4964	Belongs to the GSP D family
HLG70_12445	COG0330	HflC and HflK could
HLG70_12460	COG5484	DNA packaging
HLG70_12460	COG3728	DNA packaging
HLG70_12505	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HLG70_12510	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HLG70_12515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HLG70_12520	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HLG70_12525	COG0330	HflC and HflK could
HLG70_12530	COG0330	HflC and HflK could
HLG70_12535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLG70_12540	COG1923	regulation of RNA biosynthetic process
HLG70_12545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLG70_12550	COG1160	GTP binding
HLG70_12555	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLG70_12560	COG2976	Protein conserved in bacteria
HLG70_12580	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HLG70_12585	COG0105	UTP biosynthetic process
HLG70_12590	COG0525	valine-tRNA ligase activity
HLG70_12595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLG70_12600	COG1126	abc transporter atp-binding protein
HLG70_12605	COG0765	amino acid transport
HLG70_12610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_12615	COG1396	sequence-specific DNA binding
HLG70_12620	COG0336	Belongs to the RNA methyltransferase TrmD family
HLG70_12625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HLG70_12630	COG0228	four-way junction DNA binding
HLG70_12640	COG0425	Belongs to the sulfur carrier protein TusA family
HLG70_12645	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLG70_12665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLG70_12695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLG70_12710	COG2076	Multidrug Resistance protein
HLG70_12715	COG0633	Ferredoxin
HLG70_12715	COG3217	Mosc domain protein beta barrel domain protein
HLG70_12720	COG5285	phytanoyl-CoA dioxygenase
HLG70_12725	COG0662	Cupin 2, conserved barrel domain protein
HLG70_12750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLG70_12755	COG2358	TRAP transporter, solute receptor (TAXI family
HLG70_12765	COG2311	Membrane
HLG70_12780	COG0187	DNA topoisomerase II activity
HLG70_12790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HLG70_12800	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HLG70_12805	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HLG70_12825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLG70_12835	COG3391	amine dehydrogenase activity
HLG70_12875	COG1566	PFAM secretion protein HlyD family protein
HLG70_12880	COG2814	Major facilitator Superfamily
HLG70_12890	COG0473	3-isopropylmalate dehydrogenase activity
HLG70_12895	COG0433	COG0433 Predicted ATPase
HLG70_12900	COG0217	transcriptional regulatory protein
HLG70_12905	COG0151	Belongs to the GarS family
HLG70_12915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HLG70_12920	COG0799	negative regulation of ribosome biogenesis
HLG70_12925	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HLG70_12935	COG1301	dicarboxylic acid transport
HLG70_12940	COG4191	Histidine kinase
HLG70_12945	COG2204	response regulator
HLG70_12975	COG1530	ribonuclease E activity
HLG70_12995	COG0475	glutathione-regulated potassium exporter activity
HLG70_12995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLG70_13000	COG1132	(ABC) transporter
HLG70_13035	COG0726	polysaccharide deacetylase
HLG70_13055	COG1643	Atp-dependent helicase
HLG70_13060	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLG70_13060	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HLG70_13065	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HLG70_13075	COG0704	Plays a role in the regulation of phosphate uptake
HLG70_13080	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HLG70_13085	COG1960	acyl-CoA dehydrogenase activity
HLG70_13115	COG1177	transmembrane transport
HLG70_13120	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLG70_13125	COG3842	ATPase activity
HLG70_13135	COG3642	lipopolysaccharide core region biosynthetic process
HLG70_13145	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HLG70_13150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLG70_13160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HLG70_13160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HLG70_13175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLG70_13180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HLG70_13205	COG0583	DNA-binding transcription factor activity
HLG70_13210	COG0137	argininosuccinate synthase activity
HLG70_13215	COG3158	transport of potassium into the cell
HLG70_13220	COG0642	Histidine kinase
HLG70_13250	COG0776	regulation of translation
HLG70_13255	COG3128	pkhd-type hydroxylase
HLG70_13260	COG0626	cystathionine gamma-synthase activity
HLG70_13265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLG70_13270	COG0557	exoribonuclease II activity
HLG70_13305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLG70_13310	COG2391	methyltransferase activity
HLG70_13315	COG0069	glutamate synthase activity
HLG70_13320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLG70_13415	COG0697	spore germination
HLG70_13440	COG0628	permease
HLG70_13465	COG3909	cytochrome
HLG70_13475	COG0625	glutathione transferase activity
HLG70_13480	COG0730	response to heat
HLG70_13485	COG0482	sulfurtransferase activity
HLG70_13490	COG0583	DNA-binding transcription factor activity
HLG70_13520	COG0247	lactate metabolic process
HLG70_13525	COG0277	FAD linked oxidase domain protein
HLG70_13530	COG0277	FAD linked oxidase domain protein
HLG70_13535	COG1414	Transcriptional regulator
HLG70_13540	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_13555	COG0277	FAD linked oxidase domain protein
HLG70_13560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLG70_13565	COG0312	modulator of DNA gyrase
HLG70_13580	COG0308	aminopeptidase N
HLG70_13585	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HLG70_13605	COG0436	Aminotransferase
HLG70_13615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLG70_13620	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HLG70_13640	COG0559	Belongs to the binding-protein-dependent transport system permease family
HLG70_13655	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_13670	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_13680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HLG70_13700	COG0181	hydroxymethylbilane synthase activity
HLG70_13705	COG0861	Integral membrane protein TerC family
HLG70_13710	COG0861	Integral membrane protein TerC family
HLG70_13715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HLG70_13720	COG0045	succinate-CoA ligase (ADP-forming) activity
HLG70_13740	COG2137	regulation of response to DNA damage stimulus
HLG70_13745	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HLG70_13780	COG0540	Belongs to the ATCase OTCase family
HLG70_13830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG70_13865	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HLG70_13875	COG0305	Participates in initiation and elongation during chromosome replication
HLG70_13885	COG0359	binds to the 23S rRNA
HLG70_13890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HLG70_13895	COG2965	DNA replication, synthesis of RNA primer
HLG70_13900	COG0360	Binds together with S18 to 16S ribosomal RNA
HLG70_13905	COG3739	integral membrane protein
HLG70_13910	COG1469	GTP cyclohydrolase I activity
HLG70_13920	COG0142	geranyltranstransferase activity
HLG70_13925	COG1722	exodeoxyribonuclease VII activity
HLG70_13935	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_13960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLG70_13970	COG3842	ATPase activity
HLG70_13995	COG0501	Belongs to the peptidase M48B family
HLG70_14000	COG1760	l-serine dehydratase
HLG70_14005	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLG70_14015	COG0428	transporter
HLG70_14030	COG1473	amidohydrolase
HLG70_14035	COG0583	DNA-binding transcription factor activity
HLG70_14050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLG70_14055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HLG70_14060	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HLG70_14065	COG2251	uridine kinase activity
HLG70_14065	COG0195	Participates in both transcription termination and antitermination
HLG70_14070	COG0779	Required for maturation of 30S ribosomal subunits
HLG70_14075	COG1187	pseudouridine synthase activity
HLG70_14080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HLG70_14090	COG0583	DNA-binding transcription factor activity
HLG70_14115	COG0642	Histidine kinase
HLG70_14120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLG70_14125	COG0625	glutathione transferase activity
HLG70_14130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HLG70_14135	COG1047	Peptidyl-prolyl cis-trans
HLG70_14140	COG2003	Belongs to the UPF0758 family
HLG70_14145	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HLG70_14150	COG3483	tryptophan 2,3-dioxygenase activity
HLG70_14155	COG0254	rRNA binding
HLG70_14165	COG0534	Mate efflux family protein
HLG70_14175	COG2050	protein possibly involved in aromatic compounds catabolism
HLG70_14180	COG1024	Enoyl-CoA hydratase
HLG70_14185	COG1012	belongs to the aldehyde dehydrogenase family
HLG70_14190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLG70_14195	COG2151	metal-sulfur cluster biosynthetic enzyme
HLG70_14200	COG3396	Phenylacetate-CoA oxygenase
HLG70_14205	COG3460	Phenylacetate-CoA oxygenase
HLG70_14210	COG3396	Phenylacetate-CoA oxygenase
HLG70_14215	COG3327	negative regulation of DNA-templated transcription, initiation
HLG70_14220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HLG70_14225	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HLG70_14230	COG0501	Belongs to the peptidase M48B family
HLG70_14235	COG1162	GTPase activity
HLG70_14245	COG0335	large ribosomal subunit rRNA binding
HLG70_14280	COG0175	sulfate reduction
HLG70_14285	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HLG70_14290	COG4208	sulfate ABC transporter
HLG70_14295	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HLG70_14305	COG0450	alkyl hydroperoxide reductase
HLG70_14310	COG1960	acyl-CoA dehydrogenase activity
HLG70_14315	COG2985	domain, Protein
HLG70_14345	COG2951	lytic endotransglycosylase activity
HLG70_14360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLG70_14365	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HLG70_14370	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HLG70_14390	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HLG70_14395	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HLG70_14400	COG0287	Prephenate dehydrogenase
HLG70_14405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLG70_14415	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HLG70_14430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLG70_14455	COG0210	DNA helicase
HLG70_14460	COG0515	serine threonine protein kinase
HLG70_14460	COG3266	domain, Protein
HLG70_14480	COG2951	lytic endotransglycosylase activity
HLG70_14485	COG2258	MOSC domain
HLG70_14490	COG2833	Protein of unknown function (DUF455)
HLG70_14505	COG1132	(ABC) transporter
HLG70_14510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLG70_14510	COG0189	ligase activity
HLG70_14520	COG3237	CsbD-like
HLG70_14530	COG2823	Periplasmic or secreted lipoprotein
HLG70_14545	COG0672	)-iron permease
HLG70_14560	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HLG70_14565	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_14570	COG3243	poly(R)-hydroxyalkanoic acid synthase
HLG70_14575	COG1496	oxidoreductase activity
HLG70_14580	COG0564	pseudouridine synthase activity
HLG70_14590	COG1199	ATP-dependent helicase activity
HLG70_14595	COG2183	response to ionizing radiation
HLG70_14630	COG4774	siderophore transport
HLG70_14635	COG3712	iron ion homeostasis
HLG70_14640	COG1595	DNA-templated transcription, initiation
HLG70_14645	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HLG70_14650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLG70_14655	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLG70_14660	COG0567	Dehydrogenase, E1 component
HLG70_14665	COG1522	sequence-specific DNA binding
HLG70_14670	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HLG70_14685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLG70_14690	COG1297	OPT oligopeptide transporter protein
HLG70_14700	COG0280	phosphate acetyltransferase
HLG70_14700	COG0281	malic enzyme
HLG70_14715	COG0372	Belongs to the citrate synthase family
HLG70_14720	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HLG70_14725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLG70_14730	COG1053	succinate dehydrogenase
HLG70_14735	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HLG70_14740	COG2009	succinate dehydrogenase
HLG70_14745	COG2188	Transcriptional regulator
HLG70_14750	COG0039	L-malate dehydrogenase activity
HLG70_14770	COG1981	membrane
HLG70_14800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLG70_14810	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HLG70_14820	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HLG70_14825	COG0148	phosphopyruvate hydratase activity
HLG70_14835	COG0504	CTP synthase activity
HLG70_14850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG70_14875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_14885	COG0747	negative chemotaxis
HLG70_14890	COG4172	Belongs to the ABC transporter superfamily
HLG70_14895	COG1446	asparaginase
HLG70_14905	COG2153	protein acetylation
HLG70_14930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLG70_14940	COG4172	Belongs to the ABC transporter superfamily
HLG70_14955	COG0747	negative chemotaxis
HLG70_14970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLG70_14975	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HLG70_14980	COG0697	spore germination
HLG70_14985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLG70_14995	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HLG70_15005	COG0791	NLP P60 protein
HLG70_15015	COG0583	DNA-binding transcription factor activity
HLG70_15040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HLG70_15090	COG1381	Involved in DNA repair and RecF pathway recombination
HLG70_15095	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLG70_15100	COG0571	ribonuclease III activity
HLG70_15105	COG0681	Belongs to the peptidase S26 family
HLG70_15115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLG70_15135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLG70_15140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLG70_15150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLG70_15155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLG70_15160	COG0416	fatty acid biosynthetic process
HLG70_15165	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HLG70_15170	COG1399	metal-binding, possibly nucleic acid-binding protein
HLG70_15175	COG0424	maF-like protein
HLG70_15185	COG3023	N-Acetylmuramoyl-L-alanine amidase
HLG70_15190	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HLG70_15195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HLG70_15200	COG0546	phosphoglycolate phosphatase activity
HLG70_15205	COG0564	pseudouridine synthase activity
HLG70_15210	COG1530	ribonuclease E activity
HLG70_15215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HLG70_15220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HLG70_15225	COG0159	tryptophan synthase activity
HLG70_15235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLG70_15245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLG70_15250	COG3228	Belongs to the MtfA family
HLG70_15260	COG0251	oxidation-reduction process
HLG70_15265	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HLG70_15270	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HLG70_15285	COG2878	Part of a membrane complex involved in electron transport
HLG70_15290	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLG70_15325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLG70_15350	COG0559	Belongs to the binding-protein-dependent transport system permease family
HLG70_15370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLG70_15380	COG0183	Belongs to the thiolase family
HLG70_15390	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG70_15390	COG1024	Enoyl-CoA hydratase
HLG70_15395	COG0511	ligase activity, forming carbon-carbon bonds
HLG70_15400	COG0439	Biotin carboxylase
HLG70_15410	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_15420	COG1012	belongs to the aldehyde dehydrogenase family
HLG70_15425	COG2084	Dehydrogenase
HLG70_15430	COG1414	Transcriptional regulator
HLG70_15460	COG1268	BioY protein
HLG70_15465	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HLG70_15470	COG1122	ATPase activity
HLG70_15475	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLG70_15480	COG2917	probably involved in intracellular septation
HLG70_15490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLG70_15495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLG70_15505	COG1196	nuclear chromosome segregation
HLG70_15510	COG0477	Major facilitator Superfamily
HLG70_15515	COG1573	uracil-dna glycosylase
HLG70_15520	COG1214	PFAM Peptidase M22, glycoprotease
HLG70_15535	COG0450	alkyl hydroperoxide reductase
HLG70_15540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLG70_15550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HLG70_15555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HLG70_15560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HLG70_15565	COG0560	Phosphoserine phosphatase
HLG70_15570	COG4774	siderophore transport
HLG70_15580	COG1007	ATP synthesis coupled electron transport
HLG70_15595	COG0713	ATP synthesis coupled electron transport
HLG70_15605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLG70_15610	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HLG70_15615	COG1034	ATP synthesis coupled electron transport
HLG70_15625	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HLG70_15630	COG0649	NAD binding
HLG70_15635	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLG70_15640	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLG70_15645	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLG70_15650	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLG70_15665	COG0287	Prephenate dehydrogenase
HLG70_15675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLG70_15680	COG1597	lipid kinase activity
HLG70_15695	COG0583	DNA-binding transcription factor activity
HLG70_15710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLG70_15715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG70_15720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLG70_15735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG70_15740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLG70_15775	COG0747	negative chemotaxis
HLG70_15780	COG0747	negative chemotaxis
HLG70_15810	COG2354	Protein conserved in bacteria
HLG70_15825	COG3604	Transcriptional regulator
HLG70_15860	COG1278	Cold shock
HLG70_15875	COG0583	DNA-binding transcription factor activity
HLG70_15885	COG0747	negative chemotaxis
HLG70_15890	COG4172	Belongs to the ABC transporter superfamily
HLG70_15895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_15905	COG0583	DNA-binding transcription factor activity
HLG70_15910	COG3119	arylsulfatase activity
HLG70_15930	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_15935	COG2851	Citrate transporter
HLG70_15955	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_15960	COG4221	oxidoreductase activity
HLG70_15965	COG2207	Transcriptional regulator
HLG70_15990	COG0501	Belongs to the peptidase M48B family
HLG70_16005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLG70_16065	COG0583	DNA-binding transcription factor activity
HLG70_16085	COG0251	oxidation-reduction process
HLG70_16095	COG0747	negative chemotaxis
HLG70_16100	COG0601	transmembrane transport
HLG70_16105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_16110	COG0444	Belongs to the ABC transporter superfamily
HLG70_16115	COG4608	Belongs to the ABC transporter superfamily
HLG70_16120	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HLG70_16150	COG5383	Protein conserved in bacteria
HLG70_16155	COG0583	DNA-binding transcription factor activity
HLG70_16160	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLG70_16165	COG0149	triose-phosphate isomerase activity
HLG70_16170	COG3321	synthase
HLG70_16170	COG0604	alcohol dehydrogenase
HLG70_16185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLG70_16195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_16260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HLG70_16280	COG1301	dicarboxylic acid transport
HLG70_16305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLG70_16315	COG1185	polyribonucleotide nucleotidyltransferase activity
HLG70_16320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HLG70_16330	COG1183	phosphatidylcholine synthase activity
HLG70_16335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HLG70_16340	COG0440	acetolactate synthase activity
HLG70_16345	COG0028	Belongs to the TPP enzyme family
HLG70_16350	COG1289	transmembrane transporter activity
HLG70_16355	COG3022	response to hydroperoxide
HLG70_16360	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_16395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG70_16400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLG70_16405	COG0477	Major facilitator Superfamily
HLG70_16425	COG4948	Mandelate Racemase Muconate Lactonizing
HLG70_16465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HLG70_16470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLG70_16475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLG70_16490	COG0601	transmembrane transport
HLG70_16510	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HLG70_16510	COG0517	IMP dehydrogenase activity
HLG70_16515	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HLG70_16525	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HLG70_16530	COG1674	ftsk spoiiie
HLG70_16535	COG0492	ferredoxin-NADP+ reductase activity
HLG70_16540	COG1193	negative regulation of DNA recombination
HLG70_16560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLG70_16575	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HLG70_16580	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HLG70_16585	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HLG70_16590	COG2205	protein histidine kinase activity
HLG70_16595	COG0745	RESPONSE REGULATOR receiver
HLG70_16610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG70_16615	COG0840	transmembrane signaling receptor activity
HLG70_16645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLG70_16670	COG0612	Peptidase, M16
HLG70_16680	COG0484	heat shock protein binding
HLG70_16685	COG0443	Heat shock 70 kDa protein
HLG70_16695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HLG70_16705	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HLG70_16710	COG1420	regulation of RNA biosynthetic process
HLG70_16720	COG0497	DNA recombination
HLG70_16725	COG0735	belongs to the Fur family
HLG70_16730	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLG70_16790	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HLG70_16795	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HLG70_16800	COG0167	dihydroorotate dehydrogenase activity
HLG70_16815	COG1414	Transcriptional regulator
HLG70_16835	COG0513	Belongs to the DEAD box helicase family
HLG70_16865	COG0429	hydrolase of the alpha beta-hydrolase fold
HLG70_16870	COG4783	chaperone-mediated protein folding
HLG70_16885	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLG70_16890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLG70_16905	COG0006	proline dipeptidase activity
HLG70_16915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG70_16940	COG0632	four-way junction helicase activity
HLG70_16945	COG1090	epimerase
HLG70_16955	COG2255	four-way junction helicase activity
HLG70_16960	COG4191	Histidine kinase
HLG70_16975	COG0514	ATP-dependent DNA helicase (RecQ)
HLG70_16990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLG70_16995	COG0850	regulation of cytokinetic process
HLG70_17000	COG2894	cell division
HLG70_17005	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HLG70_17020	COG0488	(ABC) transporter
HLG70_17040	COG4608	Belongs to the ABC transporter superfamily
HLG70_17045	COG0444	Belongs to the ABC transporter superfamily
HLG70_17050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_17055	COG0601	transmembrane transport
HLG70_17060	COG0747	negative chemotaxis
HLG70_17085	COG4638	Rieske (2fe-2S)
HLG70_17090	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HLG70_17110	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HLG70_17115	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_17130	COG0411	ABC transporter
HLG70_17140	COG0463	Glycosyl transferase, family 2
HLG70_17140	COG1216	Glycosyl transferase, family 2
HLG70_17155	COG0800	Aldolase
HLG70_17165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLG70_17200	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLG70_17205	COG1538	Outer membrane efflux protein
HLG70_17210	COG1136	(ABC) transporter
HLG70_17210	COG0577	efflux transmembrane transporter activity
HLG70_17215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG70_17230	COG0259	pyridoxamine-phosphate oxidase activity
HLG70_17240	COG0579	oxidoreductase
HLG70_17250	COG0583	DNA-binding transcription factor activity
HLG70_17255	COG1960	acyl-CoA dehydrogenase activity
HLG70_17260	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_17265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_17270	COG0531	amino acid
HLG70_17275	COG0405	Gamma-glutamyltransferase
HLG70_17285	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_17290	COG0114	fumarate hydratase activity
HLG70_17295	COG0802	atpase or kinase
HLG70_17300	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLG70_17305	COG0586	Pfam SNARE associated Golgi protein
HLG70_17310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HLG70_17315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HLG70_17320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HLG70_17335	COG0617	tRNA 3'-terminal CCA addition
HLG70_17345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLG70_17350	COG2301	Belongs to the HpcH HpaI aldolase family
HLG70_17355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_17360	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HLG70_17365	COG0583	DNA-binding transcription factor activity
HLG70_17370	COG1024	Enoyl-CoA hydratase
HLG70_17380	COG1960	acyl-CoA dehydrogenase activity
HLG70_17390	COG0183	Belongs to the thiolase family
HLG70_17395	COG0318	PFAM AMP-dependent synthetase and ligase
HLG70_17420	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_17425	COG2030	dehydratase
HLG70_17430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_17450	COG1024	Enoyl-CoA hydratase
HLG70_17455	COG0752	glycyl-tRNA synthetase alpha subunit
HLG70_17460	COG0751	glycine-tRNA ligase activity
HLG70_17465	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HLG70_17470	COG0204	Acyl-transferase
HLG70_17490	COG0242	peptide deformylase activity
HLG70_17495	COG1960	acyl-CoA dehydrogenase activity
HLG70_17500	COG0700	Nucleoside recognition
HLG70_17505	COG0469	pyruvate kinase activity
HLG70_17510	COG1929	Belongs to the glycerate kinase type-1 family
HLG70_17515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLG70_17520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLG70_17545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG70_17560	COG2154	pterin-4-alpha-carbinolamine dehydratase
HLG70_17590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG70_17595	COG1120	ATPase activity
HLG70_17610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLG70_17620	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_17635	COG2982	Protein involved in outer membrane biogenesis
HLG70_17640	COG1368	sulfuric ester hydrolase activity
HLG70_17645	COG2818	Glycosylase
HLG70_17660	COG0735	belongs to the Fur family
HLG70_17675	COG2610	gluconate transmembrane transporter activity
HLG70_17690	COG0443	Heat shock 70 kDa protein
HLG70_17775	COG2011	ABC-type metal ion transport system permease component
HLG70_17780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLG70_17785	COG1501	Belongs to the glycosyl hydrolase 31 family
HLG70_17790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLG70_17790	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HLG70_17795	COG0483	inositol monophosphate 1-phosphatase activity
HLG70_17800	COG0318	PFAM AMP-dependent synthetase and ligase
HLG70_17805	COG1473	amidohydrolase
HLG70_17815	COG2855	membrane
HLG70_17825	COG2239	Acts as a magnesium transporter
HLG70_17840	COG1522	sequence-specific DNA binding
HLG70_17855	COG0028	Belongs to the TPP enzyme family
HLG70_17860	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_17875	COG0653	protein targeting
HLG70_17880	COG0739	heme binding
HLG70_17890	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HLG70_17905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HLG70_17910	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLG70_17915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLG70_17920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLG70_17930	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HLG70_17935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLG70_17940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLG70_17950	COG3116	cell division
HLG70_17955	COG0275	rRNA processing
HLG70_17960	COG2001	Belongs to the MraZ family
HLG70_17970	COG0488	(ABC) transporter
HLG70_17975	COG0418	dihydroorotase activity
HLG70_17980	COG1473	amidohydrolase
HLG70_18075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLG70_18080	COG4654	Cytochrome c, class I
HLG70_18085	COG0129	dihydroxy-acid dehydratase activity
HLG70_18130	COG2084	Dehydrogenase
HLG70_18145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLG70_18175	COG0442	prolyl-tRNA aminoacylation
HLG70_18180	COG0824	Thioesterase
HLG70_18185	COG0811	peptide transport
HLG70_18190	COG0848	biopolymer transport protein
HLG70_18200	COG0823	Involved in the tonB-independent uptake of proteins
HLG70_18215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG70_18220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HLG70_18235	COG1522	sequence-specific DNA binding
HLG70_18245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HLG70_18260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG70_18265	COG0697	spore germination
HLG70_18275	COG1346	cytolysis
HLG70_18285	COG0583	DNA-binding transcription factor activity
HLG70_18300	COG0583	DNA-binding transcription factor activity
HLG70_18315	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HLG70_18320	COG0463	Glycosyl transferase, family 2
HLG70_18330	COG0786	glutamate:sodium symporter activity
HLG70_18345	COG1671	Belongs to the UPF0178 family
HLG70_18365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLG70_18375	COG0328	RNA-DNA hybrid ribonuclease activity
HLG70_18380	COG2226	methyltransferase
HLG70_18385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLG70_18390	COG1388	LysM domain
HLG70_18390	COG0741	lytic transglycosylase activity
HLG70_18430	COG1366	Belongs to the anti-sigma-factor antagonist family
HLG70_18435	COG2172	sigma factor antagonist activity
HLG70_18440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLG70_18450	COG2770	Histidine kinase
HLG70_18450	COG2208	phosphoserine phosphatase activity
HLG70_18480	COG4792	protein secretion
HLG70_18485	COG4791	protein targeting
HLG70_18490	COG4794	Type iii secretion
HLG70_18495	COG4790	Type iii secretion
HLG70_18500	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLG70_18530	COG4669	(LipO)protein
HLG70_18600	COG4789	Type iii secretion
HLG70_18650	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_18665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_18670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLG70_18675	COG0583	DNA-binding transcription factor activity
HLG70_18690	COG2719	SpoVR family
HLG70_18695	COG2718	Belongs to the UPF0229 family
HLG70_18700	COG2766	serine protein kinase
HLG70_18715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLG70_18715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLG70_18725	COG2207	Transcriptional regulator
HLG70_18730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLG70_18735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLG70_18745	COG1881	PFAM PEBP family protein
HLG70_18750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLG70_18760	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HLG70_18765	COG0316	Belongs to the HesB IscA family
HLG70_18775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HLG70_18780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLG70_18785	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HLG70_18800	COG4177	L-phenylalanine transmembrane transporter activity
HLG70_18805	COG0559	Belongs to the binding-protein-dependent transport system permease family
HLG70_18815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HLG70_18820	COG0312	modulator of DNA gyrase
HLG70_18825	COG3028	Belongs to the UPF0307 family
HLG70_18840	COG1116	anion transmembrane transporter activity
HLG70_18845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG70_18850	COG1335	isochorismatase
HLG70_18855	COG0045	succinate-CoA ligase (ADP-forming) activity
HLG70_18855	COG1042	CoA-binding domain protein
HLG70_18855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLG70_18860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLG70_18875	COG0583	DNA-binding transcription factor activity
HLG70_18885	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_18890	COG1522	sequence-specific DNA binding
HLG70_18920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLG70_18925	COG1696	Membrane protein involved in D-alanine export
HLG70_18950	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HLG70_18950	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HLG70_18960	COG2264	protein methyltransferase activity
HLG70_18965	COG0439	Biotin carboxylase
HLG70_18970	COG0511	ligase activity, forming carbon-carbon bonds
HLG70_18975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HLG70_18980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLG70_18985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLG70_18990	COG3150	esterase
HLG70_18995	COG0557	exoribonuclease II activity
HLG70_19015	COG1175	transmembrane transport
HLG70_19030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HLG70_19035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLG70_19045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLG70_19055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLG70_19065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HLG70_19070	COG1678	Uncharacterized ACR, COG1678
HLG70_19085	COG0352	thiamine-phosphate diphosphorylase activity
HLG70_19090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HLG70_19095	COG0741	lytic transglycosylase activity
HLG70_19105	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_19110	COG1335	isochorismatase
HLG70_19115	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HLG70_19160	COG1024	Enoyl-CoA hydratase
HLG70_19165	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_19175	COG2200	EAL domain
HLG70_19175	COG2199	diguanylate cyclase activity
HLG70_19175	COG2202	Pas domain
HLG70_19240	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HLG70_19275	COG0583	DNA-binding transcription factor activity
HLG70_19280	COG0683	leucine binding
HLG70_19285	COG0154	amidase activity
HLG70_19295	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HLG70_19300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLG70_19330	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HLG70_19335	COG0237	dephospho-CoA kinase activity
HLG70_19355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HLG70_19360	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HLG70_19370	COG0477	Major facilitator Superfamily
HLG70_19385	COG1194	a g-specific adenine glycosylase
HLG70_19395	COG2226	methyltransferase
HLG70_19400	COG0246	Mannitol dehydrogenase
HLG70_19405	COG4948	Mandelate Racemase Muconate Lactonizing
HLG70_19410	COG1063	alcohol dehydrogenase
HLG70_19415	COG2186	Transcriptional regulator
HLG70_19425	COG4771	TonB-dependent receptor
HLG70_19430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLG70_19435	COG2022	thiamine diphosphate biosynthetic process
HLG70_19440	COG0351	phosphomethylpyrimidine kinase
HLG70_19445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HLG70_19455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HLG70_19465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLG70_19480	COG2226	methyltransferase
HLG70_19485	COG0745	RESPONSE REGULATOR receiver
HLG70_19500	COG0642	Histidine kinase
HLG70_19505	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HLG70_19510	COG2132	Multicopper oxidase
HLG70_19525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLG70_19530	COG0583	DNA-binding transcription factor activity
HLG70_19545	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HLG70_19550	COG1984	allophanate hydrolase subunit 2
HLG70_19560	COG1802	Transcriptional regulator
HLG70_19565	COG2860	membrane
HLG70_19575	COG2223	nitrite transmembrane transporter activity
HLG70_19580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLG70_19580	COG2813	Specifically methylates the guanine in position
HLG70_19590	COG2188	Transcriptional regulator
HLG70_19595	COG2721	sulfolactate sulfo-lyase activity
HLG70_19600	COG2721	sulfolactate sulfo-lyase activity
HLG70_19605	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_19610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLG70_19615	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HLG70_19625	COG2197	response regulator
HLG70_19640	COG2918	glutathione biosynthetic process
HLG70_19660	COG0583	DNA-binding transcription factor activity
HLG70_19670	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLG70_19715	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG70_19720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_19740	COG1024	Enoyl-CoA hydratase
HLG70_19745	COG1024	Enoyl-CoA hydratase
HLG70_19750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HLG70_19760	COG0747	negative chemotaxis
HLG70_19765	COG2988	succinylglutamate desuccinylase activity
HLG70_19770	COG0747	negative chemotaxis
HLG70_19775	COG0601	transmembrane transport
HLG70_19785	COG0444	Belongs to the ABC transporter superfamily
HLG70_19790	COG4608	Belongs to the ABC transporter superfamily
HLG70_19800	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLG70_19805	COG2171	N-acyltransferase activity
HLG70_19815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLG70_19820	COG0210	DNA helicase
HLG70_19825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLG70_19830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HLG70_19840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HLG70_19845	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HLG70_19850	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HLG70_19855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HLG70_19860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLG70_19865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HLG70_19875	COG0356	it plays a direct role in the translocation of protons across the membrane
HLG70_19890	COG1024	Enoyl-CoA hydratase
HLG70_19895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLG70_19905	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLG70_19925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLG70_19940	COG0037	tRNA processing
HLG70_19945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLG70_19950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLG70_19955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG70_19960	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HLG70_19965	COG2967	ApaG domain
HLG70_19970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLG70_19975	COG0546	phosphoglycolate phosphatase activity
HLG70_19985	COG0512	Glutamine amidotransferase of anthranilate synthase
HLG70_19990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLG70_20000	COG3284	Transcriptional regulator
HLG70_20005	COG1012	belongs to the aldehyde dehydrogenase family
HLG70_20035	COG0709	Synthesizes selenophosphate from selenide and ATP
HLG70_20040	COG1305	Transglutaminase-like
HLG70_20045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLG70_20055	COG3276	selenocysteine insertion sequence binding
HLG70_20070	COG2864	formate dehydrogenase
HLG70_20075	COG0437	4 iron, 4 sulfur cluster binding
HLG70_20090	COG1607	acyl-coa hydrolase
HLG70_20115	COG3064	Membrane
HLG70_20120	COG3585	molybdate ion transport
HLG70_20125	COG1116	anion transmembrane transporter activity
HLG70_20130	COG1464	Belongs to the NlpA lipoprotein family
HLG70_20135	COG2011	ABC-type metal ion transport system permease component
HLG70_20150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG70_20155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLG70_20160	COG0431	NADPH-dependent FMN reductase
HLG70_20165	COG1464	Belongs to the NlpA lipoprotein family
HLG70_20200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_20215	COG0543	2 iron, 2 sulfur cluster binding
HLG70_20215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLG70_20225	COG1012	belongs to the aldehyde dehydrogenase family
HLG70_20230	COG3069	C4-dicarboxylate transmembrane transporter activity
HLG70_20240	COG1802	Transcriptional regulator
HLG70_20285	COG2814	Major facilitator Superfamily
HLG70_20290	COG0840	transmembrane signaling receptor activity
HLG70_20300	COG1228	amidohydrolase
HLG70_20345	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HLG70_20350	COG5001	Diguanylate cyclase
HLG70_20360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HLG70_20370	COG5001	Diguanylate cyclase
HLG70_20370	COG3300	MHYT domain
HLG70_20380	COG2423	ornithine cyclodeaminase activity
HLG70_20385	COG1522	sequence-specific DNA binding
HLG70_20400	COG0583	DNA-binding transcription factor activity
HLG70_20410	COG4172	Belongs to the ABC transporter superfamily
HLG70_20415	COG0402	S-adenosylhomocysteine deaminase activity
HLG70_20420	COG0747	negative chemotaxis
HLG70_20425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_20435	COG2423	ornithine cyclodeaminase activity
HLG70_20440	COG0583	DNA-binding transcription factor activity
HLG70_20445	COG2814	Major facilitator Superfamily
HLG70_20465	COG2197	response regulator
HLG70_20475	COG0583	DNA-binding transcription factor activity
HLG70_20485	COG1902	pentaerythritol trinitrate reductase activity
HLG70_20490	COG0583	DNA-binding transcription factor activity
HLG70_20500	COG0154	amidase activity
HLG70_20540	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HLG70_20550	COG0861	Integral membrane protein TerC family
HLG70_20555	COG0583	DNA-binding transcription factor activity
HLG70_20570	COG0596	Alpha beta hydrolase
HLG70_20580	COG1418	mRNA catabolic process
HLG70_20595	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_20620	COG1522	sequence-specific DNA binding
HLG70_20635	COG2814	Major facilitator Superfamily
HLG70_20660	COG1999	signal sequence binding
HLG70_20670	COG1612	heme a metabolic process
HLG70_20705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLG70_20725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLG70_20730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLG70_20750	COG0067	glutamate synthase
HLG70_20750	COG0069	glutamate synthase activity
HLG70_20750	COG0070	glutamate synthase
HLG70_20760	COG3047	cAMP biosynthetic process
HLG70_20765	COG0583	DNA-binding transcription factor activity
HLG70_20770	COG0477	Major facilitator Superfamily
HLG70_20785	COG1127	ABC transporter
HLG70_20790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HLG70_20795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HLG70_20800	COG2853	Lipoprotein
HLG70_20810	COG1131	(ABC) transporter
HLG70_20815	COG0842	Transport permease protein
HLG70_20825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HLG70_20830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HLG70_20835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLG70_20840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLG70_20845	COG0131	Imidazoleglycerol-phosphate dehydratase
HLG70_20850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HLG70_20855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HLG70_20860	COG0107	imidazoleglycerol-phosphate synthase activity
HLG70_20870	COG0140	phosphoribosyl-ATP diphosphatase activity
HLG70_20875	COG0537	adenosine 5'-monophosphoramidase activity
HLG70_20880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLG70_20885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLG70_20900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLG70_20905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLG70_20910	COG1970	mechanosensitive ion channel activity
HLG70_20915	COG0723	plastoquinol--plastocyanin reductase activity
HLG70_20920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HLG70_20925	COG2857	Cytochrome c1
HLG70_20930	COG0625	glutathione transferase activity
HLG70_20935	COG2969	positive regulation of protein catabolic process
HLG70_20955	COG0154	amidase activity
HLG70_20960	COG1414	Transcriptional regulator
HLG70_20965	COG0667	Aldo Keto reductase
HLG70_20970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_20980	COG1012	belongs to the aldehyde dehydrogenase family
HLG70_21000	COG0583	DNA-binding transcription factor activity
HLG70_21010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLG70_21020	COG2207	Transcriptional regulator
HLG70_21020	COG3708	Transcriptional regulator
HLG70_21030	COG1160	GTP binding
HLG70_21035	COG4166	transmembrane transport
HLG70_21040	COG0601	transmembrane transport
HLG70_21045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_21060	COG5339	Protein conserved in bacteria
HLG70_21065	COG5339	Protein conserved in bacteria
HLG70_21070	COG0513	Belongs to the DEAD box helicase family
HLG70_21075	COG1280	lysine exporter protein (LysE YggA)
HLG70_21080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HLG70_21100	COG0583	DNA-binding transcription factor activity
HLG70_21110	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HLG70_21120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLG70_21125	COG0154	amidase activity
HLG70_21130	COG1609	Transcriptional regulator
HLG70_21135	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLG70_21140	COG3842	ATPase activity
HLG70_21145	COG1653	transport
HLG70_21150	COG1175	transmembrane transport
HLG70_21155	COG0395	ABC-type sugar transport system, permease component
HLG70_21170	COG0018	arginyl-trna synthetase
HLG70_21180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLG70_21200	COG0778	Nitroreductase
HLG70_21205	COG1280	lysine exporter protein (LysE YggA)
HLG70_21210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLG70_21220	COG1742	UPF0060 membrane protein
HLG70_21230	COG1473	amidohydrolase
HLG70_21235	COG1960	acyl-CoA dehydrogenase activity
HLG70_21240	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HLG70_21245	COG0183	Belongs to the thiolase family
HLG70_21250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLG70_21260	COG0477	Major facilitator Superfamily
HLG70_21290	COG0753	catalase activity
HLG70_21305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLG70_21315	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_21325	COG0583	DNA-binding transcription factor activity
HLG70_21330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_21335	COG0765	amino acid transport
HLG70_21340	COG0765	amino acid transport
HLG70_21355	COG2358	TRAP transporter, solute receptor (TAXI family
HLG70_21365	COG2922	Belongs to the Smg family
HLG70_21370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLG70_21380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLG70_21380	COG0551	DNA topoisomerase type I activity
HLG70_21390	COG1116	anion transmembrane transporter activity
HLG70_21390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLG70_21395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG70_21400	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_21405	COG0028	Belongs to the TPP enzyme family
HLG70_21410	COG1522	sequence-specific DNA binding
HLG70_21415	COG3781	membrane
HLG70_21445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG70_21460	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLG70_21470	COG1744	ABC transporter substrate-binding protein PnrA-like
HLG70_21475	COG3845	ABC transporter
HLG70_21480	COG4603	Belongs to the binding-protein-dependent transport system permease family
HLG70_21490	COG0402	S-adenosylhomocysteine deaminase activity
HLG70_21495	COG0251	oxidation-reduction process
HLG70_21510	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_21550	COG1177	transmembrane transport
HLG70_21555	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLG70_21560	COG3842	ATPase activity
HLG70_21570	COG1304	FMN binding
HLG70_21595	COG1126	abc transporter atp-binding protein
HLG70_21600	COG0765	amino acid transport
HLG70_21605	COG0765	amino acid transport
HLG70_21610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_21615	COG0583	DNA-binding transcription factor activity
HLG70_21620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG70_21640	COG0592	DNA-directed DNA polymerase activity
HLG70_21645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HLG70_21650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HLG70_21655	COG0594	ribonuclease P activity
HLG70_21660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HLG70_21670	COG0753	catalase activity
HLG70_21680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HLG70_21690	COG2175	clavaminate synthase activity
HLG70_21695	COG1473	amidohydrolase
HLG70_21700	COG4608	Belongs to the ABC transporter superfamily
HLG70_21705	COG0444	Belongs to the ABC transporter superfamily
HLG70_21710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_21715	COG0601	transmembrane transport
HLG70_21725	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HLG70_21735	COG0038	chloride channel
HLG70_21745	COG0642	Histidine kinase
HLG70_21765	COG0436	Aminotransferase
HLG70_21770	COG3180	Ammonia monooxygenase
HLG70_21775	COG1278	Cold shock
HLG70_21780	COG0445	tRNA wobble uridine modification
HLG70_21785	COG0357	Ribosomal RNA small subunit methyltransferase G
HLG70_21790	COG1192	Involved in chromosome partitioning
HLG70_21800	COG1475	DNA binding
HLG70_21805	COG0252	asparaginase activity
HLG70_21810	COG0583	DNA-binding transcription factor activity
HLG70_21835	COG1349	DNA-binding transcription factor activity
HLG70_21845	COG3842	ATPase activity
HLG70_21890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLG70_21910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HLG70_21915	COG0081	regulation of translation
HLG70_21920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HLG70_21925	COG0222	ribosome binding
HLG70_21930	COG0085	RNA polymerase activity
HLG70_21935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HLG70_21950	COG5002	protein histidine kinase activity
HLG70_21965	COG0745	RESPONSE REGULATOR receiver
HLG70_21970	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HLG70_21975	COG0049	tRNA binding
HLG70_21980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HLG70_21985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLG70_21990	COG0051	transcription antitermination factor activity, RNA binding
HLG70_21995	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HLG70_22005	COG0089	rRNA binding
HLG70_22010	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HLG70_22015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HLG70_22020	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HLG70_22025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HLG70_22030	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HLG70_22035	COG0255	Belongs to the universal ribosomal protein uL29 family
HLG70_22040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HLG70_22085	COG2207	Transcriptional regulator
HLG70_22105	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HLG70_22110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HLG70_22115	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HLG70_22120	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HLG70_22125	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HLG70_22130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HLG70_22135	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HLG70_22140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HLG70_22145	COG1841	ribosomal large subunit assembly
HLG70_22150	COG0200	Binds to the 23S rRNA
HLG70_22155	COG0201	protein transport
HLG70_22160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HLG70_22165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HLG70_22170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HLG70_22175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HLG70_22180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HLG70_22185	COG0202	RNA polymerase activity
HLG70_22190	COG0203	ribosomal protein L17
HLG70_22200	COG1324	tolerance protein
HLG70_22205	COG4232	protein-disulfide reductase activity
HLG70_22220	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HLG70_22230	COG1333	cytochrome c biogenesis protein
HLG70_22235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLG70_22250	COG1965	Belongs to the frataxin family
HLG70_22260	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HLG70_22265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HLG70_22270	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HLG70_22285	COG2814	Major facilitator Superfamily
HLG70_22295	COG0583	DNA-binding transcription factor activity
HLG70_22300	COG4948	Mandelate Racemase Muconate Lactonizing
HLG70_22330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HLG70_22335	COG2186	Transcriptional regulator
HLG70_22360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG70_22365	COG1956	GAF domain-containing protein
HLG70_22370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG70_22385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLG70_22410	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HLG70_22415	COG3568	Endonuclease Exonuclease Phosphatase
HLG70_22420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLG70_22425	COG0697	spore germination
HLG70_22430	COG2814	Major facilitator Superfamily
HLG70_22440	COG0166	Belongs to the GPI family
HLG70_22445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLG70_22450	COG0859	PFAM glycosyl transferase family 9
HLG70_22465	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HLG70_22475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HLG70_22500	COG1686	Belongs to the peptidase S11 family
HLG70_22510	COG2921	Belongs to the UPF0250 family
HLG70_22530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLG70_22535	COG1682	transport, permease protein
HLG70_22545	COG0438	transferase activity, transferring glycosyl groups
HLG70_22560	COG1216	Glycosyl transferase, family 2
HLG70_22635	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HLG70_22640	COG1216	Glycosyl transferase, family 2
HLG70_22645	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HLG70_22665	COG2096	Adenosyltransferase
HLG70_22675	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HLG70_22680	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HLG70_22690	COG0523	cobalamin synthesis protein
HLG70_22695	COG0735	belongs to the Fur family
HLG70_22725	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HLG70_22730	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HLG70_22740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HLG70_22755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLG70_22760	COG0154	amidase activity
HLG70_22765	COG0477	Major facilitator Superfamily
HLG70_22800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG70_22805	COG0583	DNA-binding transcription factor activity
HLG70_22810	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_22815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HLG70_22820	COG0066	3-isopropylmalate dehydratase activity
HLG70_22835	COG0438	transferase activity, transferring glycosyl groups
HLG70_22840	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HLG70_22845	COG1950	PFAM Membrane protein of
HLG70_22850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HLG70_22875	COG2308	Evidence 4 Homologs of previously reported genes of
HLG70_22880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLG70_22900	COG0513	Belongs to the DEAD box helicase family
HLG70_22905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HLG70_22915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLG70_22920	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_22930	COG3189	MarR family transcriptional regulator
HLG70_22960	COG0640	Transcriptional regulator
HLG70_22975	COG0318	PFAM AMP-dependent synthetase and ligase
HLG70_23015	COG1846	Transcriptional regulator
HLG70_23020	COG1764	response to oxidative stress
HLG70_23045	COG0583	DNA-binding transcription factor activity
HLG70_23070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLG70_23075	COG1280	lysine exporter protein (LysE YggA)
HLG70_23085	COG0708	Exodeoxyribonuclease III
HLG70_23090	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HLG70_23105	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLG70_23110	COG0154	amidase activity
HLG70_23115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLG70_23120	COG1077	Cell shape determining protein MreB Mrl
HLG70_23125	COG1792	Involved in formation and maintenance of cell shape
HLG70_23135	COG0768	penicillin binding
HLG70_23140	COG0772	Belongs to the SEDS family
HLG70_23145	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HLG70_23150	COG0471	metal ion transport
HLG70_23155	COG1309	transcriptional regulator
HLG70_23165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLG70_23175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLG70_23180	COG2823	Periplasmic or secreted lipoprotein
HLG70_23185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HLG70_23200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLG70_23210	COG1660	Displays ATPase and GTPase activities
HLG70_23225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG70_23230	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HLG70_23240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HLG70_23245	COG1137	ATPase activity
HLG70_23260	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HLG70_23270	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HLG70_23280	COG1271	oxidase subunit
HLG70_23285	COG1294	oxidase, subunit
HLG70_23295	COG4988	ABC transporter
HLG70_23300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HLG70_23320	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLG70_23325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLG70_23330	COG1238	metal cluster binding
HLG70_23345	COG0071	Belongs to the small heat shock protein (HSP20) family
HLG70_23350	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_23355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HLG70_23360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG70_23365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_23380	COG0758	DNA mediated transformation
HLG70_23385	COG0242	peptide deformylase activity
HLG70_23390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLG70_23400	COG0546	phosphoglycolate phosphatase activity
HLG70_23420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLG70_23425	COG1280	lysine exporter protein (LysE YggA)
HLG70_23430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLG70_23430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLG70_23440	COG5000	phosphorelay sensor kinase activity
HLG70_23445	COG2204	response regulator
HLG70_23450	COG0569	domain protein
HLG70_23455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLG70_23460	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HLG70_23465	COG2226	methyltransferase
HLG70_23470	COG1040	competence protein
HLG70_23475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HLG70_23485	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HLG70_23490	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HLG70_23495	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HLG70_23500	COG1054	Belongs to the UPF0176 family
HLG70_23505	COG0588	phosphoglycerate mutase activity
HLG70_23510	COG4942	peptidase
HLG70_23515	COG0793	Belongs to the peptidase S41A family
HLG70_23530	COG2186	Transcriptional regulator
HLG70_23545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLG70_23560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HLG70_23565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HLG70_23570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HLG70_23575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HLG70_23580	COG1414	Transcriptional regulator
HLG70_23590	COG0142	geranyltranstransferase activity
HLG70_23655	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLG70_23660	COG2084	Dehydrogenase
HLG70_23690	COG0235	Class ii aldolase
HLG70_23695	COG2271	Major facilitator Superfamily
HLG70_23700	COG3622	Belongs to the hyi family
HLG70_23705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLG70_23710	COG2084	Dehydrogenase
HLG70_23715	COG3395	kinase activity
HLG70_23720	COG2186	Transcriptional regulator
HLG70_23745	COG3622	Belongs to the hyi family
HLG70_23760	COG5006	permease, DMT superfamily
HLG70_23770	COG1522	sequence-specific DNA binding
HLG70_23775	COG3264	Mechanosensitive ion channel
HLG70_23775	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HLG70_23790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HLG70_23795	COG2890	protein-(glutamine-N5) methyltransferase activity
HLG70_23800	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HLG70_23815	COG1464	Belongs to the NlpA lipoprotein family
HLG70_23835	COG0318	PFAM AMP-dependent synthetase and ligase
HLG70_23865	COG0583	DNA-binding transcription factor activity
HLG70_23880	COG0625	glutathione transferase activity
HLG70_23885	COG0288	reversible hydration of carbon dioxide
HLG70_23905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLG70_23915	COG4829	muconolactone delta-isomerase
HLG70_23920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLG70_23930	COG1414	Transcriptional regulator
HLG70_23935	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_23940	COG2031	fatty acid transporter
HLG70_23945	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG70_23955	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HLG70_23960	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HLG70_23985	COG0129	dihydroxy-acid dehydratase activity
HLG70_23990	COG0583	DNA-binding transcription factor activity
HLG70_23995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLG70_24000	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLG70_24010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLG70_24015	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_24020	COG0410	ABC transporter
HLG70_24050	COG2186	Transcriptional regulator
HLG70_24060	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HLG70_24075	COG2177	Part of the ABC transporter FtsEX involved in
HLG70_24080	COG2884	Cell division ATP-binding protein ftsE
HLG70_24085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_24090	COG4597	amino acid ABC transporter
HLG70_24095	COG0765	amino acid transport
HLG70_24100	COG1126	abc transporter atp-binding protein
HLG70_24120	COG1129	ABC transporter
HLG70_24125	COG4177	L-phenylalanine transmembrane transporter activity
HLG70_24140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG70_24145	COG2081	HI0933 family
HLG70_24155	COG0077	Prephenate dehydratase
HLG70_24155	COG1605	Chorismate mutase
HLG70_24195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG70_24200	COG0583	DNA-binding transcription factor activity
HLG70_24205	COG0628	permease
HLG70_24225	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLG70_24230	COG3842	ATPase activity
HLG70_24240	COG0277	FAD linked oxidase domain protein
HLG70_24255	COG0477	Major facilitator Superfamily
HLG70_24270	COG1695	Transcriptional regulator
HLG70_24280	COG0583	DNA-binding transcription factor activity
HLG70_24305	COG0745	RESPONSE REGULATOR receiver
HLG70_24310	COG2205	protein histidine kinase activity
HLG70_24350	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_24360	COG3246	L-lysine catabolic process to acetate
HLG70_24370	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLG70_24385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLG70_24405	COG1487	ribonuclease activity
HLG70_24415	COG4638	Rieske (2fe-2S)
HLG70_24445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLG70_24450	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_24455	COG0210	DNA helicase
HLG70_24460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_24480	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HLG70_24490	COG0583	DNA-binding transcription factor activity
HLG70_24495	COG0235	Class ii aldolase
HLG70_24505	COG0436	Aminotransferase
HLG70_24510	COG0583	DNA-binding transcription factor activity
HLG70_24520	COG0477	Major facilitator Superfamily
HLG70_24620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLG70_24655	COG2233	PERMEase
HLG70_24660	COG0326	Molecular chaperone. Has ATPase activity
HLG70_24665	COG2814	Major facilitator Superfamily
HLG70_24680	COG0402	S-adenosylhomocysteine deaminase activity
HLG70_24685	COG0747	negative chemotaxis
HLG70_24690	COG0601	transmembrane transport
HLG70_24695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_24700	COG4172	Belongs to the ABC transporter superfamily
HLG70_24735	COG2271	Major facilitator Superfamily
HLG70_24740	COG4948	Mandelate Racemase Muconate Lactonizing
HLG70_24745	COG0800	Aldolase
HLG70_24750	COG3734	2-keto-3-deoxy-galactonokinase
HLG70_24755	COG1414	Transcriptional regulator
HLG70_24760	COG0625	glutathione transferase activity
HLG70_24775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLG70_24780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLG70_24785	COG1652	LysM domain
HLG70_24805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HLG70_24810	COG0583	DNA-binding transcription factor activity
HLG70_24815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_24820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLG70_24850	COG0235	Class ii aldolase
HLG70_24860	COG0477	Major facilitator Superfamily
HLG70_24865	COG0625	glutathione transferase activity
HLG70_24885	COG1132	(ABC) transporter
HLG70_24895	COG0473	3-isopropylmalate dehydrogenase activity
HLG70_24905	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_24910	COG1802	Transcriptional regulator
HLG70_24915	COG0583	DNA-binding transcription factor activity
HLG70_24920	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_24925	COG0154	amidase activity
HLG70_24930	COG0456	acetyltransferase
HLG70_24930	COG1846	Transcriptional regulator
HLG70_24950	COG3246	L-lysine catabolic process to acetate
HLG70_24955	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_24965	COG3712	iron ion homeostasis
HLG70_24975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG70_24985	COG0583	DNA-binding transcription factor activity
HLG70_25000	COG3135	benzoate transporter
HLG70_25005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HLG70_25050	COG3279	Response regulator of the LytR AlgR family
HLG70_25055	COG2972	Histidine kinase
HLG70_25065	COG2072	flavoprotein involved in K transport
HLG70_25075	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_25080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLG70_25085	COG0235	Class ii aldolase
HLG70_25095	COG0583	DNA-binding transcription factor activity
HLG70_25115	COG0165	Argininosuccinate lyase
HLG70_25125	COG2814	Major facilitator Superfamily
HLG70_25130	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_25145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLG70_25190	COG3284	Transcriptional regulator
HLG70_25200	COG0583	DNA-binding transcription factor activity
HLG70_25210	COG0583	DNA-binding transcription factor activity
HLG70_25220	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HLG70_25225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLG70_25235	COG1131	(ABC) transporter
HLG70_25255	COG0559	Belongs to the binding-protein-dependent transport system permease family
HLG70_25265	COG1122	ATPase activity
HLG70_25320	COG1987	bacterial-type flagellum assembly
HLG70_25325	COG1684	flagellar biosynthetic protein fliR
HLG70_25330	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLG70_25335	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLG70_25340	COG4787	bacterial-type flagellum-dependent cell motility
HLG70_25355	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HLG70_25360	COG1706	bacterial-type flagellum-dependent cell motility
HLG70_25375	COG1677	Flagellar hook-basal body complex protein FliE
HLG70_25380	COG1766	The M ring may be actively involved in energy transduction
HLG70_25390	COG1317	bacterial-type flagellum organization
HLG70_25395	COG1157	protein secretion by the type III secretion system
HLG70_25410	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HLG70_25435	COG1338	Plays a role in the flagellum-specific transport system
HLG70_25505	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HLG70_25515	COG1764	response to oxidative stress
HLG70_25520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLG70_25565	COG0625	glutathione transferase activity
HLG70_25570	COG0583	DNA-binding transcription factor activity
HLG70_25575	COG3976	FMN-binding domain protein
HLG70_25575	COG0431	NADPH-dependent FMN reductase
HLG70_25575	COG1053	succinate dehydrogenase
HLG70_25595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG70_25605	COG1294	oxidase, subunit
HLG70_25610	COG1271	oxidase subunit
HLG70_25615	COG0697	spore germination
HLG70_25630	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_25640	COG0842	Transport permease protein
HLG70_25645	COG0842	Transport permease protein
HLG70_25645	COG1129	ABC transporter
HLG70_25650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG70_25665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLG70_25680	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HLG70_25695	COG1054	Belongs to the UPF0176 family
HLG70_25700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLG70_25700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLG70_25710	COG0489	protein tyrosine kinase activity
HLG70_25725	COG0717	Belongs to the dCTP deaminase family
HLG70_25755	COG2081	HI0933 family
HLG70_25770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HLG70_25775	COG0509	glycine decarboxylation via glycine cleavage system
HLG70_25780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLG70_25780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLG70_25795	COG0154	amidase activity
HLG70_25800	COG4172	Belongs to the ABC transporter superfamily
HLG70_25805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG70_25810	COG0601	transmembrane transport
HLG70_25830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLG70_25835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG70_25860	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HLG70_25865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLG70_25870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HLG70_25885	COG0438	transferase activity, transferring glycosyl groups
HLG70_25895	COG0438	transferase activity, transferring glycosyl groups
HLG70_25900	COG0438	transferase activity, transferring glycosyl groups
HLG70_25910	COG0166	Belongs to the GPI family
HLG70_25925	COG0277	FAD linked oxidase domain protein
HLG70_25930	COG0745	RESPONSE REGULATOR receiver
HLG70_25945	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HLG70_25945	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HLG70_25955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLG70_25965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLG70_25970	COG2186	Transcriptional regulator
HLG70_25975	COG1368	sulfuric ester hydrolase activity
HLG70_25980	COG0204	Acyl-transferase
HLG70_26015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HLG70_26025	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HLG70_26030	COG0840	transmembrane signaling receptor activity
HLG70_26035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HLG70_26055	COG0193	aminoacyl-tRNA hydrolase activity
HLG70_26065	COG0012	GTP binding
HLG70_26075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLG70_26080	COG3842	ATPase activity
HLG70_26090	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HLG70_26095	COG1175	transmembrane transport
HLG70_26100	COG0583	DNA-binding transcription factor activity
HLG70_26110	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG70_26125	COG1414	Transcriptional regulator
HLG70_26135	COG0477	Major facilitator Superfamily
HLG70_26150	COG3135	benzoate transporter
HLG70_26155	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLG70_26160	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HLG70_26165	COG0742	ribosomal rna small subunit methyltransferase
HLG70_26180	COG3639	organic phosphonate transmembrane transporter activity
HLG70_26185	COG3639	organic phosphonate transmembrane transporter activity
HLG70_26190	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HLG70_26215	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HLG70_26220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLG70_26230	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HLG70_26235	COG1546	Belongs to the CinA family
HLG70_26240	COG0284	orotidine-5'-phosphate decarboxylase activity
HLG70_26245	COG1252	NADH dehydrogenase
HLG70_26250	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HLG70_26255	COG2186	Transcriptional regulator
HLG70_26260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLG70_26270	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HLG70_26275	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_26280	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLG70_26285	COG2721	sulfolactate sulfo-lyase activity
HLG70_26290	COG0246	Mannitol dehydrogenase
HLG70_26295	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HLG70_26300	COG0410	ABC transporter
HLG70_26305	COG1137	ATPase activity
HLG70_26315	COG0559	Belongs to the binding-protein-dependent transport system permease family
HLG70_26330	COG1917	Cupin 2, conserved barrel domain protein
HLG70_26350	COG1846	Transcriptional regulator
HLG70_26360	COG0459	protein refolding
HLG70_26365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HLG70_26410	COG3706	GGDEF domain
HLG70_26420	COG1595	DNA-templated transcription, initiation
HLG70_26425	COG3712	iron ion homeostasis
HLG70_26450	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HLG70_26460	COG0647	UMP catabolic process
HLG70_26465	COG1737	Transcriptional regulator
HLG70_26490	COG3246	L-lysine catabolic process to acetate
HLG70_26505	COG2267	carboxylic ester hydrolase activity
HLG70_26525	COG0583	DNA-binding transcription factor activity
HLG70_26535	COG0523	cobalamin synthesis protein
HLG70_26540	COG1335	isochorismatase
HLG70_26545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLG70_26550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLG70_26555	COG1802	Transcriptional regulator
HLG70_26560	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HLG70_26570	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_26595	COG1960	acyl-CoA dehydrogenase activity
HLG70_26600	COG1960	acyl-CoA dehydrogenase activity
HLG70_26605	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLG70_26615	COG2030	dehydratase
HLG70_26620	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_26635	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_26650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_26660	COG3181	Tripartite tricarboxylate transporter family receptor
HLG70_26670	COG2814	Major facilitator Superfamily
HLG70_26680	COG2721	sulfolactate sulfo-lyase activity
HLG70_26685	COG0583	DNA-binding transcription factor activity
HLG70_26700	COG2133	pyrroloquinoline quinone binding
HLG70_26700	COG5183	chlorophyll binding
HLG70_26755	COG1222	aaa ATPase
HLG70_26810	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_26820	COG0028	Belongs to the TPP enzyme family
HLG70_26835	COG0583	DNA-binding transcription factor activity
HLG70_26840	COG0028	Belongs to the TPP enzyme family
HLG70_26860	COG1053	succinate dehydrogenase
HLG70_26890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLG70_26895	COG0583	DNA-binding transcription factor activity
HLG70_26900	COG2084	Dehydrogenase
HLG70_26950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG70_26960	COG0583	DNA-binding transcription factor activity
HLG70_26965	COG0473	3-isopropylmalate dehydrogenase activity
HLG70_26970	COG4585	Histidine kinase
HLG70_26985	COG0456	acetyltransferase
HLG70_26995	COG0667	Aldo Keto reductase
HLG70_27005	COG0546	phosphoglycolate phosphatase activity
HLG70_27020	COG2818	Glycosylase
HLG70_27040	COG2197	response regulator
HLG70_27045	COG2205	protein histidine kinase activity
HLG70_27045	COG0784	Response regulator, receiver
HLG70_27065	COG0625	glutathione transferase activity
HLG70_27090	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLG70_27095	COG3346	SURF1 family
HLG70_27100	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HLG70_27105	COG1845	cytochrome c oxidase, subunit III
HLG70_27110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLG70_27115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HLG70_27120	COG0477	Major facilitator Superfamily
HLG70_27170	COG0583	DNA-binding transcription factor activity
HLG70_27175	COG0861	Integral membrane protein TerC family
HLG70_27180	COG4106	trans-aconitate 2-methyltransferase activity
HLG70_27195	COG4774	siderophore transport
HLG70_27200	COG2207	Transcriptional regulator
HLG70_27205	COG2807	transmembrane transport
HLG70_27225	COG0330	HflC and HflK could
HLG70_27230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLG70_27250	COG4773	Receptor
HLG70_27260	COG3712	iron ion homeostasis
HLG70_27270	COG0784	Response regulator, receiver
HLG70_27270	COG4191	Histidine kinase
HLG70_27275	COG1595	DNA-templated transcription, initiation
HLG70_27280	COG3712	iron ion homeostasis
HLG70_27290	COG2706	6-phosphogluconolactonase activity
HLG70_27310	COG1309	transcriptional regulator
HLG70_27330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLG70_27335	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_27345	COG1690	Belongs to the RtcB family
HLG70_27350	COG4650	regulator
HLG70_27355	COG1285	pathogenesis
HLG70_27360	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_27395	COG3145	DNA-N1-methyladenine dioxygenase activity
HLG70_27405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLG70_27410	COG1396	sequence-specific DNA binding
HLG70_27430	COG0583	DNA-binding transcription factor activity
HLG70_27455	COG0583	DNA-binding transcription factor activity
HLG70_27470	COG0697	spore germination
HLG70_27500	COG0280	phosphate acetyltransferase
HLG70_27500	COG0281	malic enzyme
HLG70_27515	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HLG70_27525	COG4772	TonB-dependent receptor
HLG70_27540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HLG70_27545	COG1845	cytochrome c oxidase, subunit III
HLG70_27550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLG70_27560	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HLG70_27580	COG1999	signal sequence binding
HLG70_27595	COG1126	abc transporter atp-binding protein
HLG70_27600	COG0765	amino acid transport
HLG70_27605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_27610	COG3191	aminopeptidase activity
HLG70_27615	COG1272	protein, Hemolysin III
HLG70_27620	COG1522	sequence-specific DNA binding
HLG70_27630	COG1113	amino acid transport
HLG70_27650	COG2378	regulation of single-species biofilm formation
HLG70_27665	COG1595	DNA-templated transcription, initiation
HLG70_27670	COG3712	iron ion homeostasis
HLG70_27680	COG3720	iron ion transport
HLG70_27685	COG4558	Periplasmic binding protein
HLG70_27690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG70_27695	COG1120	ATPase activity
HLG70_27700	COG1666	GTP binding
HLG70_27730	COG0671	phosphoesterase, PA-phosphatase related
HLG70_27805	COG0456	acetyltransferase
HLG70_27820	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_27840	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLG70_27845	COG0583	DNA-binding transcription factor activity
HLG70_27865	COG4774	siderophore transport
HLG70_27870	COG3712	iron ion homeostasis
HLG70_27880	COG3468	outer membrane autotransporter barrel domain protein
HLG70_27895	COG2223	nitrite transmembrane transporter activity
HLG70_27905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HLG70_27910	COG3383	formate dehydrogenase (NAD+) activity
HLG70_27930	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLG70_27940	COG0303	'Molybdopterin
HLG70_27945	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLG70_27950	COG0314	molybdopterin synthase activity
HLG70_27960	COG0315	cyclic pyranopterin monophosphate synthase activity
HLG70_27970	COG0412	Dienelactone hydrolase
HLG70_27980	COG0678	peroxiredoxin activity
HLG70_27990	COG0697	spore germination
HLG70_28035	COG0667	Aldo Keto reductase
HLG70_28040	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HLG70_28045	COG4535	Mg2 and Co2 transporter CorC
HLG70_28050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HLG70_28055	COG1702	phosphate starvation-inducible protein PhoH
HLG70_28060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLG70_28070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLG70_28090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLG70_28095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLG70_28100	COG1862	Preprotein translocase
HLG70_28105	COG0343	queuine tRNA-ribosyltransferase activity
HLG70_28110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HLG70_28120	COG2027	D-alanyl-D-alanine carboxypeptidase
HLG70_28125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HLG70_28130	COG1648	precorrin-2 dehydrogenase activity
HLG70_28130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLG70_28140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLG70_28145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG70_28150	COG1116	anion transmembrane transporter activity
HLG70_28155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLG70_28160	COG0243	molybdopterin cofactor binding
HLG70_28170	COG4575	ribosome binding
HLG70_28185	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HLG70_28190	COG0741	lytic transglycosylase activity
HLG70_28195	COG0436	Aminotransferase
HLG70_28205	COG0281	malic enzyme
HLG70_28205	COG0280	phosphate acetyltransferase
HLG70_28215	COG2732	(Barnase) inhibitor
HLG70_28220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLG70_28225	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLG70_28230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLG70_28235	COG0126	phosphoglycerate kinase activity
HLG70_28245	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HLG70_28250	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLG70_28270	COG0625	glutathione transferase activity
HLG70_28315	COG0306	phosphate transporter
HLG70_28325	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLG70_28335	COG0739	heme binding
HLG70_28345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HLG70_28360	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HLG70_28365	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HLG70_28370	COG3639	organic phosphonate transmembrane transporter activity
HLG70_28390	COG0583	DNA-binding transcription factor activity
HLG70_28395	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HLG70_28400	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HLG70_28405	COG3454	Phosphonate metabolism
HLG70_28410	COG2188	Transcriptional regulator
HLG70_28415	COG3624	Phosphonate C-P lyase system protein PhnG
HLG70_28425	COG3626	phosphonate metabolism
HLG70_28430	COG3627	carbon phosphorus lyase activity
HLG70_28435	COG4107	phosphonate C-P lyase system protein PhnK
HLG70_28440	COG4778	phosphonate C-P lyase system protein PhnL
HLG70_28445	COG3454	Phosphonate metabolism
HLG70_28465	COG1301	dicarboxylic acid transport
HLG70_28485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLG70_28525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HLG70_28535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HLG70_28540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLG70_28545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HLG70_28550	COG0009	L-threonylcarbamoyladenylate synthase
HLG70_28555	COG1414	Transcriptional regulator
HLG70_28560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLG70_28575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_28585	COG0010	Belongs to the arginase family
HLG70_28595	COG0765	amino acid transport
HLG70_28600	COG1126	abc transporter atp-binding protein
HLG70_28605	COG0028	Belongs to the TPP enzyme family
HLG70_28650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HLG70_28680	COG1960	acyl-CoA dehydrogenase activity
HLG70_28685	COG0028	Belongs to the TPP enzyme family
HLG70_28690	COG0583	DNA-binding transcription factor activity
HLG70_28695	COG4974	Belongs to the 'phage' integrase family
HLG70_28700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLG70_28720	COG1686	Belongs to the peptidase S11 family
HLG70_28745	COG1074	ATP-dependent DNA helicase activity
HLG70_28770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLG70_28785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG70_28790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLG70_28800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG70_28830	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLG70_28835	COG0505	Belongs to the CarA family
HLG70_28840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HLG70_28850	COG0406	alpha-ribazole phosphatase activity
HLG70_28860	COG3842	ATPase activity
HLG70_28880	COG2233	PERMEase
HLG70_28885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLG70_28890	COG1534	Rna-binding protein
HLG70_28895	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HLG70_28900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLG70_28910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLG70_28945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLG70_28950	COG2814	Major facilitator Superfamily
HLG70_28965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HLG70_29020	COG3468	outer membrane autotransporter barrel domain protein
HLG70_29035	COG0833	amino acid
HLG70_29055	COG3121	Chaperone
HLG70_29110	COG5001	Diguanylate cyclase
HLG70_29115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_29115	COG2205	protein histidine kinase activity
HLG70_29125	COG2197	response regulator
HLG70_29130	COG0784	Response regulator, receiver
HLG70_29130	COG2205	protein histidine kinase activity
HLG70_29130	COG5002	protein histidine kinase activity
HLG70_29155	COG1335	isochorismatase
HLG70_29160	COG0583	DNA-binding transcription factor activity
HLG70_29170	COG1609	Transcriptional regulator
HLG70_29180	COG0251	oxidation-reduction process
HLG70_29185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG70_29200	COG0765	amino acid transport
HLG70_29210	COG2207	Transcriptional regulator
HLG70_29215	COG0667	Aldo Keto reductase
HLG70_29240	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HLG70_29255	COG0500	methyltransferase
HLG70_29260	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_29265	COG3321	synthase
HLG70_29265	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_29265	COG0604	alcohol dehydrogenase
HLG70_29290	COG1028	Short-chain dehydrogenase reductase Sdr
HLG70_29305	COG0371	Dehydrogenase
HLG70_29310	COG1802	Transcriptional regulator
HLG70_29315	COG3959	Transketolase, thiamine diphosphate binding domain
HLG70_29320	COG3958	Transketolase
HLG70_29325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HLG70_29335	COG3938	Belongs to the proline racemase family
HLG70_29340	COG1177	transmembrane transport
HLG70_29345	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLG70_29350	COG3842	ATPase activity
HLG70_29410	COG3264	Mechanosensitive ion channel
HLG70_29410	COG1511	domain protein
HLG70_29415	COG0583	DNA-binding transcription factor activity
HLG70_29420	COG0427	acetyl-CoA hydrolase
HLG70_29425	COG0583	DNA-binding transcription factor activity