locus-tag	class	description
I6I07_00035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I07_00070	COG1268	BioY protein
I6I07_00075	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6I07_00080	COG1122	ATPase activity
I6I07_00085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I07_00090	COG2917	probably involved in intracellular septation
I6I07_00100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I07_00105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I07_00115	COG1196	nuclear chromosome segregation
I6I07_00120	COG0477	Major facilitator Superfamily
I6I07_00125	COG1573	uracil-dna glycosylase
I6I07_00130	COG1214	PFAM Peptidase M22, glycoprotease
I6I07_00145	COG0450	alkyl hydroperoxide reductase
I6I07_00150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I07_00160	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I07_00165	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I07_00170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I07_00175	COG0560	Phosphoserine phosphatase
I6I07_00180	COG3210	domain, Protein
I6I07_00190	COG4774	siderophore transport
I6I07_00200	COG1007	ATP synthesis coupled electron transport
I6I07_00215	COG0713	ATP synthesis coupled electron transport
I6I07_00225	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I07_00230	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6I07_00235	COG1034	ATP synthesis coupled electron transport
I6I07_00245	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6I07_00250	COG0649	NAD binding
I6I07_00255	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I07_00260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I07_00265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I07_00270	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I07_00295	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I07_00300	COG1597	lipid kinase activity
I6I07_00315	COG0583	DNA-binding transcription factor activity
I6I07_00320	COG1309	transcriptional regulator
I6I07_00330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I07_00350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I07_00355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I07_00360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I07_00375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I07_00420	COG0747	negative chemotaxis
I6I07_00450	COG1522	sequence-specific DNA binding
I6I07_00460	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6I07_00465	COG3604	Transcriptional regulator
I6I07_00505	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_00510	COG2851	Citrate transporter
I6I07_00520	COG0642	Histidine kinase
I6I07_00530	COG4566	intracellular signal transduction
I6I07_00535	COG4191	Histidine kinase
I6I07_00565	COG1595	DNA-templated transcription, initiation
I6I07_00585	COG3712	iron ion homeostasis
I6I07_00590	COG1595	DNA-templated transcription, initiation
I6I07_00620	COG1116	anion transmembrane transporter activity
I6I07_00655	COG1910	domain protein
I6I07_00680	COG0840	transmembrane signaling receptor activity
I6I07_00710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I07_00720	COG1136	(ABC) transporter
I6I07_00760	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I07_00765	COG0149	triose-phosphate isomerase activity
I6I07_00770	COG3321	synthase
I6I07_00770	COG0604	alcohol dehydrogenase
I6I07_00785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I07_00795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I07_00825	COG2819	hydrolase of the alpha beta superfamily
I6I07_00835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I07_00845	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I07_00850	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I07_00860	COG1183	phosphatidylcholine synthase activity
I6I07_00865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I07_00870	COG0440	acetolactate synthase activity
I6I07_00875	COG0028	Belongs to the TPP enzyme family
I6I07_00880	COG1289	transmembrane transporter activity
I6I07_00885	COG3022	response to hydroperoxide
I6I07_00890	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_00925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I07_00965	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I07_00970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I07_00975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I07_00990	COG0601	transmembrane transport
I6I07_01010	COG0517	IMP dehydrogenase activity
I6I07_01010	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I07_01015	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I07_01020	COG0251	oxidation-reduction process
I6I07_01025	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I07_01030	COG1674	ftsk spoiiie
I6I07_01035	COG0492	ferredoxin-NADP+ reductase activity
I6I07_01040	COG1193	negative regulation of DNA recombination
I6I07_01050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I07_01070	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I07_01075	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I07_01080	COG2205	protein histidine kinase activity
I6I07_01085	COG0745	RESPONSE REGULATOR receiver
I6I07_01100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I07_01105	COG0840	transmembrane signaling receptor activity
I6I07_01130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I07_01155	COG0612	Peptidase, M16
I6I07_01165	COG0484	heat shock protein binding
I6I07_01170	COG0443	Heat shock 70 kDa protein
I6I07_01180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I07_01190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I07_01195	COG1420	regulation of RNA biosynthetic process
I6I07_01205	COG0497	DNA recombination
I6I07_01210	COG0735	belongs to the Fur family
I6I07_01215	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I07_01225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I07_01295	COG0583	DNA-binding transcription factor activity
I6I07_01305	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I07_01310	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6I07_01315	COG0167	dihydroorotate dehydrogenase activity
I6I07_01330	COG1414	Transcriptional regulator
I6I07_01335	COG1546	Belongs to the CinA family
I6I07_01335	COG1058	Belongs to the CinA family
I6I07_01360	COG0252	asparaginase activity
I6I07_01370	COG0513	Belongs to the DEAD box helicase family
I6I07_01380	COG4771	TonB-dependent receptor
I6I07_01385	COG2814	Major facilitator Superfamily
I6I07_01425	COG4783	chaperone-mediated protein folding
I6I07_01440	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I07_01445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I07_01460	COG0006	proline dipeptidase activity
I6I07_01470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I07_01495	COG0632	four-way junction helicase activity
I6I07_01500	COG1090	epimerase
I6I07_01510	COG2255	four-way junction helicase activity
I6I07_01530	COG0514	ATP-dependent DNA helicase (RecQ)
I6I07_01545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I07_01555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I07_01560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I07_01565	COG1414	Transcriptional regulator
I6I07_01570	COG0850	regulation of cytokinetic process
I6I07_01575	COG2894	cell division
I6I07_01580	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I07_01595	COG0488	(ABC) transporter
I6I07_01615	COG4608	Belongs to the ABC transporter superfamily
I6I07_01620	COG0444	Belongs to the ABC transporter superfamily
I6I07_01625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_01630	COG0601	transmembrane transport
I6I07_01635	COG0747	negative chemotaxis
I6I07_01660	COG4638	Rieske (2fe-2S)
I6I07_01685	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6I07_01690	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_01715	COG1216	Glycosyl transferase, family 2
I6I07_01715	COG0463	Glycosyl transferase, family 2
I6I07_01730	COG0800	Aldolase
I6I07_01740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I07_01755	COG1595	DNA-templated transcription, initiation
I6I07_01760	COG3712	iron ion homeostasis
I6I07_01790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I07_01795	COG1538	Outer membrane efflux protein
I6I07_01800	COG1136	(ABC) transporter
I6I07_01800	COG0577	efflux transmembrane transporter activity
I6I07_01805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I07_01820	COG0259	pyridoxamine-phosphate oxidase activity
I6I07_01825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I07_01830	COG0579	oxidoreductase
I6I07_01840	COG0583	DNA-binding transcription factor activity
I6I07_01850	COG2175	clavaminate synthase activity
I6I07_01870	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I07_01875	COG0583	DNA-binding transcription factor activity
I6I07_01880	COG1960	acyl-CoA dehydrogenase activity
I6I07_01890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I07_01895	COG0531	amino acid
I6I07_01900	COG0405	Gamma-glutamyltransferase
I6I07_01910	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_01925	COG4804	nuclease activity
I6I07_01930	COG2003	Belongs to the UPF0758 family
I6I07_01945	COG1475	DNA binding
I6I07_01955	COG5489	Protein of unknown function (DUF736)
I6I07_01985	COG1192	Involved in chromosome partitioning
I6I07_02020	COG5002	protein histidine kinase activity
I6I07_02025	COG0745	RESPONSE REGULATOR receiver
I6I07_02030	COG2132	Multicopper oxidase
I6I07_02075	COG0583	DNA-binding transcription factor activity
I6I07_02095	COG4962	Type ii secretion system protein e
I6I07_02100	COG3838	Conjugal transfer protein Trbc
I6I07_02110	COG3451	type IV secretory pathway VirB4
I6I07_02135	COG3504	Conjugal transfer protein
I6I07_02150	COG0114	fumarate hydratase activity
I6I07_02155	COG0802	atpase or kinase
I6I07_02160	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I07_02170	COG0586	Pfam SNARE associated Golgi protein
I6I07_02175	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I07_02180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I07_02190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I07_02205	COG0617	tRNA 3'-terminal CCA addition
I6I07_02215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I07_02220	COG2301	Belongs to the HpcH HpaI aldolase family
I6I07_02230	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6I07_02240	COG1024	Enoyl-CoA hydratase
I6I07_02250	COG1960	acyl-CoA dehydrogenase activity
I6I07_02265	COG0318	PFAM AMP-dependent synthetase and ligase
I6I07_02275	COG2070	2-Nitropropane dioxygenase
I6I07_02290	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_02295	COG2030	dehydratase
I6I07_02320	COG1024	Enoyl-CoA hydratase
I6I07_02330	COG0751	glycine-tRNA ligase activity
I6I07_02335	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I07_02340	COG0204	Acyl-transferase
I6I07_02360	COG0242	peptide deformylase activity
I6I07_02365	COG1960	acyl-CoA dehydrogenase activity
I6I07_02370	COG0700	Nucleoside recognition
I6I07_02375	COG0469	pyruvate kinase activity
I6I07_02380	COG1929	Belongs to the glycerate kinase type-1 family
I6I07_02385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I07_02390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I07_02400	COG3178	'Phosphotransferase
I6I07_02430	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6I07_02460	COG1595	DNA-templated transcription, initiation
I6I07_02470	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_02485	COG2982	Protein involved in outer membrane biogenesis
I6I07_02490	COG1368	sulfuric ester hydrolase activity
I6I07_02495	COG2818	Glycosylase
I6I07_02520	COG0735	belongs to the Fur family
I6I07_02530	COG0583	DNA-binding transcription factor activity
I6I07_02535	COG0840	transmembrane signaling receptor activity
I6I07_02590	COG2011	ABC-type metal ion transport system permease component
I6I07_02595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I07_02600	COG1501	Belongs to the glycosyl hydrolase 31 family
I6I07_02605	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I07_02605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I07_02610	COG0483	inositol monophosphate 1-phosphatase activity
I6I07_02615	COG0318	PFAM AMP-dependent synthetase and ligase
I6I07_02620	COG1473	amidohydrolase
I6I07_02625	COG0583	DNA-binding transcription factor activity
I6I07_02630	COG2855	membrane
I6I07_02640	COG2239	Acts as a magnesium transporter
I6I07_02655	COG1522	sequence-specific DNA binding
I6I07_02660	COG0300	oxidoreductase activity
I6I07_02670	COG0028	Belongs to the TPP enzyme family
I6I07_02675	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_02690	COG0653	protein targeting
I6I07_02695	COG0739	heme binding
I6I07_02705	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6I07_02710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I07_02720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I07_02725	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I07_02730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I07_02735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I07_02745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I07_02750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I07_02755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I07_02765	COG3116	cell division
I6I07_02770	COG0275	rRNA processing
I6I07_02775	COG2001	Belongs to the MraZ family
I6I07_02785	COG0488	(ABC) transporter
I6I07_02790	COG0418	dihydroorotase activity
I6I07_02795	COG1473	amidohydrolase
I6I07_02820	COG2948	multi-organism process
I6I07_02835	COG3846	protein secretion by the type IV secretion system
I6I07_02850	COG3451	type IV secretory pathway VirB4
I6I07_02860	COG3838	Conjugal transfer protein Trbc
I6I07_02865	COG4962	Type ii secretion system protein e
I6I07_02885	COG0583	DNA-binding transcription factor activity
I6I07_02890	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I07_02895	COG2194	sulfuric ester hydrolase activity
I6I07_02925	COG3038	cytochrome b561
I6I07_02935	COG0642	Histidine kinase
I6I07_02970	COG1192	Involved in chromosome partitioning
I6I07_02995	COG1396	sequence-specific DNA binding
I6I07_03005	COG5489	Protein of unknown function (DUF736)
I6I07_03010	COG0640	Transcriptional regulator
I6I07_03015	COG0346	lactoylglutathione lyase activity
I6I07_03025	COG0798	PFAM Bile acid sodium symporter
I6I07_03035	COG1695	Transcriptional regulator
I6I07_03075	COG2003	Belongs to the UPF0758 family
I6I07_03080	COG4804	nuclease activity
I6I07_03120	COG1522	sequence-specific DNA binding
I6I07_03130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I07_03135	COG4654	Cytochrome c, class I
I6I07_03140	COG0129	dihydroxy-acid dehydratase activity
I6I07_03185	COG2084	Dehydrogenase
I6I07_03200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I07_03235	COG0824	Thioesterase
I6I07_03240	COG0811	peptide transport
I6I07_03245	COG0848	biopolymer transport protein
I6I07_03255	COG0823	Involved in the tonB-independent uptake of proteins
I6I07_03270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I07_03275	COG1120	ATPase activity
I6I07_03290	COG1522	sequence-specific DNA binding
I6I07_03300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I07_03315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I07_03320	COG0697	spore germination
I6I07_03340	COG0583	DNA-binding transcription factor activity
I6I07_03350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I07_03370	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I07_03390	COG0583	DNA-binding transcription factor activity
I6I07_03405	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I07_03410	COG0463	Glycosyl transferase, family 2
I6I07_03420	COG0786	glutamate:sodium symporter activity
I6I07_03435	COG1671	Belongs to the UPF0178 family
I6I07_03455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I07_03460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I07_03470	COG0328	RNA-DNA hybrid ribonuclease activity
I6I07_03475	COG2226	methyltransferase
I6I07_03480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I07_03485	COG1388	LysM domain
I6I07_03485	COG0741	lytic transglycosylase activity
I6I07_03525	COG1366	Belongs to the anti-sigma-factor antagonist family
I6I07_03530	COG2172	sigma factor antagonist activity
I6I07_03535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I07_03545	COG2208	phosphoserine phosphatase activity
I6I07_03545	COG2770	Histidine kinase
I6I07_03575	COG4792	protein secretion
I6I07_03580	COG4791	protein targeting
I6I07_03585	COG4794	Type iii secretion
I6I07_03590	COG4790	Type iii secretion
I6I07_03595	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I07_03625	COG4669	(LipO)protein
I6I07_03700	COG4789	Type iii secretion
I6I07_03735	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_03745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I07_03755	COG1942	4-Oxalocrotonate Tautomerase
I6I07_03770	COG2719	SpoVR family
I6I07_03775	COG2718	Belongs to the UPF0229 family
I6I07_03780	COG2766	serine protein kinase
I6I07_03795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I07_03795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I07_03800	COG1335	isochorismatase
I6I07_03810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I07_03820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I07_03825	COG1280	lysine exporter protein (LysE YggA)
I6I07_03835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I07_03850	COG0316	Belongs to the HesB IscA family
I6I07_03860	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I07_03865	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I07_03870	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I07_03890	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I07_03905	COG0312	modulator of DNA gyrase
I6I07_03910	COG3028	Belongs to the UPF0307 family
I6I07_03925	COG1116	anion transmembrane transporter activity
I6I07_03930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I07_03935	COG1335	isochorismatase
I6I07_03940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I07_03940	COG1042	CoA-binding domain protein
I6I07_03940	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I07_03945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I07_03950	COG2814	Major facilitator Superfamily
I6I07_03960	COG0583	DNA-binding transcription factor activity
I6I07_03970	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_03975	COG1522	sequence-specific DNA binding
I6I07_04005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I07_04010	COG1696	Membrane protein involved in D-alanine export
I6I07_04035	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I07_04035	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I07_04045	COG2264	protein methyltransferase activity
I6I07_04050	COG0439	Biotin carboxylase
I6I07_04055	COG0511	ligase activity, forming carbon-carbon bonds
I6I07_04060	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I07_04065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I07_04070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I07_04075	COG3150	esterase
I6I07_04080	COG0557	exoribonuclease II activity
I6I07_04100	COG1175	transmembrane transport
I6I07_04105	COG3842	ATPase activity
I6I07_04115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I07_04120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I07_04130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I07_04135	COG1126	abc transporter atp-binding protein
I6I07_04140	COG0765	amino acid transport
I6I07_04150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_04155	COG0436	Aminotransferase
I6I07_04160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I07_04180	COG0540	Belongs to the ATCase OTCase family
I6I07_04185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I07_04190	COG1678	Uncharacterized ACR, COG1678
I6I07_04205	COG0352	thiamine-phosphate diphosphorylase activity
I6I07_04210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I07_04215	COG0741	lytic transglycosylase activity
I6I07_04225	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_04230	COG1335	isochorismatase
I6I07_04235	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6I07_04240	COG4638	Rieske (2fe-2S)
I6I07_04280	COG1024	Enoyl-CoA hydratase
I6I07_04285	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_04320	COG0410	ABC transporter
I6I07_04355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I07_04375	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I07_04380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I07_04410	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6I07_04415	COG0237	dephospho-CoA kinase activity
I6I07_04435	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I07_04440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I07_04450	COG0477	Major facilitator Superfamily
I6I07_04485	COG1605	Chorismate mutase
I6I07_04485	COG0077	Prephenate dehydratase
I6I07_04495	COG2081	HI0933 family
I6I07_04500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I07_04520	COG1126	abc transporter atp-binding protein
I6I07_04525	COG0765	amino acid transport
I6I07_04530	COG4597	amino acid ABC transporter
I6I07_04535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_04540	COG2884	Cell division ATP-binding protein ftsE
I6I07_04545	COG2177	Part of the ABC transporter FtsEX involved in
I6I07_04570	COG1194	a g-specific adenine glycosylase
I6I07_04590	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6I07_04605	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_04620	COG0246	Mannitol dehydrogenase
I6I07_04625	COG4948	Mandelate Racemase Muconate Lactonizing
I6I07_04630	COG1126	abc transporter atp-binding protein
I6I07_04635	COG0765	amino acid transport
I6I07_04645	COG1063	alcohol dehydrogenase
I6I07_04660	COG2186	Transcriptional regulator
I6I07_04670	COG4771	TonB-dependent receptor
I6I07_04675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I07_04680	COG2022	thiamine diphosphate biosynthetic process
I6I07_04685	COG0351	phosphomethylpyrimidine kinase
I6I07_04690	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I07_04700	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I07_04710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I07_04725	COG2226	methyltransferase
I6I07_04730	COG0745	RESPONSE REGULATOR receiver
I6I07_04735	COG5002	protein histidine kinase activity
I6I07_04755	COG2132	Multicopper oxidase
I6I07_04770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I07_04785	COG4774	siderophore transport
I6I07_04810	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I07_04815	COG1984	allophanate hydrolase subunit 2
I6I07_04825	COG1802	Transcriptional regulator
I6I07_04830	COG2860	membrane
I6I07_04840	COG2223	nitrite transmembrane transporter activity
I6I07_04845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I07_04845	COG2813	Specifically methylates the guanine in position
I6I07_04850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I07_04855	COG2188	Transcriptional regulator
I6I07_04860	COG2721	sulfolactate sulfo-lyase activity
I6I07_04865	COG2721	sulfolactate sulfo-lyase activity
I6I07_04870	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_04875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I07_04880	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I07_04910	COG2918	glutathione biosynthetic process
I6I07_04920	COG2988	succinylglutamate desuccinylase activity
I6I07_04930	COG0583	DNA-binding transcription factor activity
I6I07_04940	COG1802	Transcriptional regulator
I6I07_04955	COG1129	ABC transporter
I6I07_04975	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I07_04990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I07_04995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I07_05020	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I07_05035	COG1309	transcriptional regulator
I6I07_05045	COG1024	Enoyl-CoA hydratase
I6I07_05050	COG1024	Enoyl-CoA hydratase
I6I07_05055	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I07_05065	COG0747	negative chemotaxis
I6I07_05070	COG0583	DNA-binding transcription factor activity
I6I07_05080	COG2988	succinylglutamate desuccinylase activity
I6I07_05085	COG0747	negative chemotaxis
I6I07_05090	COG0601	transmembrane transport
I6I07_05100	COG0444	Belongs to the ABC transporter superfamily
I6I07_05105	COG4608	Belongs to the ABC transporter superfamily
I6I07_05115	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I07_05120	COG2171	N-acyltransferase activity
I6I07_05130	COG4221	oxidoreductase activity
I6I07_05135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I07_05150	COG0210	DNA helicase
I6I07_05155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I07_05160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I07_05170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I07_05180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I07_05185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I07_05190	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I07_05205	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I07_05220	COG1024	Enoyl-CoA hydratase
I6I07_05225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I07_05235	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I07_05250	COG0583	DNA-binding transcription factor activity
I6I07_05255	COG3473	Maleate cis-trans isomerase
I6I07_05280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I07_05295	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I07_05300	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I07_05320	COG0583	DNA-binding transcription factor activity
I6I07_05325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I07_05345	COG0037	tRNA processing
I6I07_05360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I07_05370	COG2967	ApaG domain
I6I07_05375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I07_05380	COG0546	phosphoglycolate phosphatase activity
I6I07_05390	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I07_05395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I07_05400	COG0134	indole-3-glycerol-phosphate synthase activity
I6I07_05405	COG3284	Transcriptional regulator
I6I07_05410	COG1012	belongs to the aldehyde dehydrogenase family
I6I07_05440	COG0709	Synthesizes selenophosphate from selenide and ATP
I6I07_05445	COG1305	Transglutaminase-like
I6I07_05450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I07_05460	COG3276	selenocysteine insertion sequence binding
I6I07_05465	COG1921	L-seryl-tRNASec selenium transferase activity
I6I07_05475	COG2864	formate dehydrogenase
I6I07_05480	COG0437	4 iron, 4 sulfur cluster binding
I6I07_05495	COG1607	acyl-coa hydrolase
I6I07_05520	COG3064	Membrane
I6I07_05525	COG3585	molybdate ion transport
I6I07_05530	COG1116	anion transmembrane transporter activity
I6I07_05535	COG1464	Belongs to the NlpA lipoprotein family
I6I07_05540	COG2011	ABC-type metal ion transport system permease component
I6I07_05555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I07_05560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I07_05565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I07_05570	COG0431	NADPH-dependent FMN reductase
I6I07_05575	COG1464	Belongs to the NlpA lipoprotein family
I6I07_05600	COG0747	negative chemotaxis
I6I07_05610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_05620	COG0589	response to stress
I6I07_05640	COG3069	C4-dicarboxylate transmembrane transporter activity
I6I07_05650	COG1802	Transcriptional regulator
I6I07_05710	COG3188	usher protein
I6I07_05725	COG2814	Major facilitator Superfamily
I6I07_05730	COG0840	transmembrane signaling receptor activity
I6I07_05745	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6I07_05750	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I07_05760	COG2188	Transcriptional regulator
I6I07_05775	COG0737	Belongs to the 5'-nucleotidase family
I6I07_05820	COG0463	Glycosyl transferase, family 2
I6I07_05825	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I07_05835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I07_05845	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I07_05850	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I07_05855	COG5001	Diguanylate cyclase
I6I07_05860	COG2423	ornithine cyclodeaminase activity
I6I07_05865	COG0583	DNA-binding transcription factor activity
I6I07_05870	COG2814	Major facilitator Superfamily
I6I07_05895	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I07_05910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I07_05915	COG1120	ATPase activity
I6I07_05920	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I07_05925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I07_05930	COG4592	Periplasmic binding protein
I6I07_05935	COG4774	siderophore transport
I6I07_05940	COG2207	Transcriptional regulator
I6I07_05950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I07_05985	COG2814	Major facilitator Superfamily
I6I07_05990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I07_06010	COG1999	signal sequence binding
I6I07_06020	COG1612	heme a metabolic process
I6I07_06055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I07_06075	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I07_06100	COG0067	glutamate synthase
I6I07_06100	COG0069	glutamate synthase activity
I6I07_06100	COG0070	glutamate synthase
I6I07_06110	COG2059	Chromate
I6I07_06125	COG1984	allophanate hydrolase subunit 2
I6I07_06140	COG0511	ligase activity, forming carbon-carbon bonds
I6I07_06145	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I07_06150	COG0583	DNA-binding transcription factor activity
I6I07_06160	COG0583	DNA-binding transcription factor activity
I6I07_06165	COG0477	Major facilitator Superfamily
I6I07_06175	COG2070	2-Nitropropane dioxygenase
I6I07_06180	COG1127	ABC transporter
I6I07_06185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I07_06190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I07_06195	COG2853	Lipoprotein
I6I07_06205	COG1131	(ABC) transporter
I6I07_06210	COG0842	Transport permease protein
I6I07_06220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I07_06225	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I07_06230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I07_06235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I07_06240	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I07_06245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I07_06250	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I07_06255	COG0107	imidazoleglycerol-phosphate synthase activity
I6I07_06260	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I07_06265	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I07_06270	COG0537	adenosine 5'-monophosphoramidase activity
I6I07_06275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I07_06280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I07_06295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I07_06300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I07_06305	COG1970	mechanosensitive ion channel activity
I6I07_06310	COG0723	plastoquinol--plastocyanin reductase activity
I6I07_06315	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6I07_06320	COG2857	Cytochrome c1
I6I07_06325	COG0625	glutathione transferase activity
I6I07_06330	COG2969	positive regulation of protein catabolic process
I6I07_06365	COG0583	DNA-binding transcription factor activity
I6I07_06375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I07_06385	COG2207	Transcriptional regulator
I6I07_06385	COG3708	Transcriptional regulator
I6I07_06395	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I07_06400	COG0747	negative chemotaxis
I6I07_06405	COG0601	transmembrane transport
I6I07_06410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_06415	COG4172	Belongs to the ABC transporter superfamily
I6I07_06420	COG1228	amidohydrolase
I6I07_06425	COG5339	Protein conserved in bacteria
I6I07_06430	COG5339	Protein conserved in bacteria
I6I07_06435	COG0513	Belongs to the DEAD box helicase family
I6I07_06440	COG1280	lysine exporter protein (LysE YggA)
I6I07_06445	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I07_06460	COG0697	spore germination
I6I07_06465	COG0583	DNA-binding transcription factor activity
I6I07_06475	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I07_06490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I07_06500	COG1609	Transcriptional regulator
I6I07_06505	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I07_06515	COG1653	transport
I6I07_06520	COG1175	transmembrane transport
I6I07_06525	COG0395	ABC-type sugar transport system, permease component
I6I07_06560	COG0018	arginyl-trna synthetase
I6I07_06570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I07_06595	COG1280	lysine exporter protein (LysE YggA)
I6I07_06610	COG1742	UPF0060 membrane protein
I6I07_06620	COG1473	amidohydrolase
I6I07_06625	COG1960	acyl-CoA dehydrogenase activity
I6I07_06630	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6I07_06635	COG0183	Belongs to the thiolase family
I6I07_06640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I07_06660	COG2207	Transcriptional regulator
I6I07_06705	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_06720	COG0318	PFAM AMP-dependent synthetase and ligase
I6I07_06750	COG3339	Conserved Protein
I6I07_06775	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6I07_06805	COG2814	Major facilitator Superfamily
I6I07_06810	COG4977	sequence-specific DNA binding
I6I07_06845	COG1595	DNA-templated transcription, initiation
I6I07_06850	COG3712	iron ion homeostasis
I6I07_06860	COG1595	DNA-templated transcription, initiation
I6I07_06865	COG3712	iron ion homeostasis
I6I07_06875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I07_06880	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_06885	COG1309	transcriptional regulator
I6I07_06890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_06895	COG0765	amino acid transport
I6I07_06900	COG0765	amino acid transport
I6I07_06920	COG2358	TRAP transporter, solute receptor (TAXI family
I6I07_06930	COG2922	Belongs to the Smg family
I6I07_06935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I07_06960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I07_06965	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_06970	COG0028	Belongs to the TPP enzyme family
I6I07_06975	COG1522	sequence-specific DNA binding
I6I07_06980	COG3781	membrane
I6I07_06995	COG2814	Major facilitator Superfamily
I6I07_07010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I07_07025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I07_07035	COG1744	ABC transporter substrate-binding protein PnrA-like
I6I07_07040	COG3845	ABC transporter
I6I07_07045	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6I07_07055	COG0402	S-adenosylhomocysteine deaminase activity
I6I07_07085	COG3210	domain, Protein
I6I07_07095	COG0251	oxidation-reduction process
I6I07_07120	COG1177	transmembrane transport
I6I07_07125	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I07_07130	COG3842	ATPase activity
I6I07_07195	COG1177	transmembrane transport
I6I07_07200	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I07_07240	COG1126	abc transporter atp-binding protein
I6I07_07245	COG0765	amino acid transport
I6I07_07250	COG0765	amino acid transport
I6I07_07255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_07260	COG0583	DNA-binding transcription factor activity
I6I07_07270	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6I07_07280	COG1741	Belongs to the pirin family
I6I07_07295	COG0583	DNA-binding transcription factor activity
I6I07_07310	COG0592	DNA-directed DNA polymerase activity
I6I07_07315	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I07_07320	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I07_07325	COG0594	ribonuclease P activity
I6I07_07330	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I07_07340	COG0753	catalase activity
I6I07_07345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I07_07355	COG3712	iron ion homeostasis
I6I07_07370	COG2175	clavaminate synthase activity
I6I07_07375	COG1473	amidohydrolase
I6I07_07380	COG4608	Belongs to the ABC transporter superfamily
I6I07_07385	COG0444	Belongs to the ABC transporter superfamily
I6I07_07390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_07395	COG0601	transmembrane transport
I6I07_07405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I07_07425	COG0038	chloride channel
I6I07_07435	COG2205	protein histidine kinase activity
I6I07_07455	COG0436	Aminotransferase
I6I07_07460	COG3180	Ammonia monooxygenase
I6I07_07465	COG1278	Cold shock
I6I07_07470	COG0445	tRNA wobble uridine modification
I6I07_07475	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I07_07480	COG1192	Involved in chromosome partitioning
I6I07_07490	COG1475	DNA binding
I6I07_07495	COG0252	asparaginase activity
I6I07_07500	COG0583	DNA-binding transcription factor activity
I6I07_07525	COG1349	DNA-binding transcription factor activity
I6I07_07535	COG3842	ATPase activity
I6I07_07540	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I07_07580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I07_07590	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I07_07600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I07_07605	COG0081	regulation of translation
I6I07_07610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I07_07615	COG0222	ribosome binding
I6I07_07620	COG0085	RNA polymerase activity
I6I07_07625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I07_07640	COG5002	protein histidine kinase activity
I6I07_07655	COG0745	RESPONSE REGULATOR receiver
I6I07_07660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I07_07665	COG0049	tRNA binding
I6I07_07670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I07_07675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I07_07680	COG0051	transcription antitermination factor activity, RNA binding
I6I07_07685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I07_07695	COG0089	rRNA binding
I6I07_07700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I07_07705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I07_07710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I07_07715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I07_07720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I07_07725	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I07_07730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I07_07745	COG3307	-O-antigen
I6I07_07755	COG1215	transferase activity, transferring glycosyl groups
I6I07_07770	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I07_07810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I07_07830	COG0455	bacterial-type flagellum organization
I6I07_07835	COG1215	transferase activity, transferring glycosyl groups
I6I07_07840	COG1215	transferase activity, transferring glycosyl groups
I6I07_07845	COG1215	transferase activity, transferring glycosyl groups
I6I07_07850	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6I07_07855	COG0457	Tetratricopeptide repeat
I6I07_07890	COG4177	L-phenylalanine transmembrane transporter activity
I6I07_07915	COG2207	Transcriptional regulator
I6I07_07935	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I07_07940	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I07_07945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I07_07950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I07_07955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I07_07960	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I07_07965	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I07_07970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I07_07975	COG1841	ribosomal large subunit assembly
I6I07_07980	COG0200	Binds to the 23S rRNA
I6I07_07985	COG0201	protein transport
I6I07_07990	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I07_07995	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I07_08000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I07_08005	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I07_08010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I07_08015	COG0202	RNA polymerase activity
I6I07_08020	COG0203	ribosomal protein L17
I6I07_08030	COG1324	tolerance protein
I6I07_08035	COG4232	protein-disulfide reductase activity
I6I07_08050	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I07_08060	COG1333	cytochrome c biogenesis protein
I6I07_08065	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I07_08070	COG0019	diaminopimelate decarboxylase activity
I6I07_08080	COG1965	Belongs to the frataxin family
I6I07_08090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I07_08095	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I07_08100	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I07_08105	COG0625	glutathione transferase activity
I6I07_08115	COG2814	Major facilitator Superfamily
I6I07_08155	COG2186	Transcriptional regulator
I6I07_08180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I07_08185	COG1956	GAF domain-containing protein
I6I07_08190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I07_08205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I07_08230	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I07_08235	COG3568	Endonuclease Exonuclease Phosphatase
I6I07_08250	COG2814	Major facilitator Superfamily
I6I07_08265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I07_08275	COG0728	peptidoglycan biosynthetic process
I6I07_08325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I07_08330	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_08335	COG1083	cytidylyl-transferase
I6I07_08340	COG0673	inositol 2-dehydrogenase activity
I6I07_08350	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I07_08355	COG2089	acid synthase
I6I07_08365	COG0859	PFAM glycosyl transferase family 9
I6I07_08380	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6I07_08390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I07_08425	COG2921	Belongs to the UPF0250 family
I6I07_08430	COG0321	lipoyl(octanoyl) transferase activity
I6I07_08445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I07_08455	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6I07_08465	COG2096	Adenosyltransferase
I6I07_08475	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6I07_08480	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I07_08490	COG0523	cobalamin synthesis protein
I6I07_08495	COG0735	belongs to the Fur family
I6I07_08510	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I07_08520	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I07_08525	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I07_08535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I07_08540	COG1560	Kdo2-lipid A biosynthetic process
I6I07_08550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I07_08555	COG0154	amidase activity
I6I07_08560	COG0477	Major facilitator Superfamily
I6I07_08570	COG0583	DNA-binding transcription factor activity
I6I07_08575	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_08585	COG0066	3-isopropylmalate dehydratase activity
I6I07_08590	COG0596	Alpha beta hydrolase
I6I07_08600	COG0438	transferase activity, transferring glycosyl groups
I6I07_08605	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I07_08610	COG1950	PFAM Membrane protein of
I6I07_08635	COG1305	Transglutaminase-like
I6I07_08645	COG2308	Evidence 4 Homologs of previously reported genes of
I6I07_08650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I07_08675	COG0513	Belongs to the DEAD box helicase family
I6I07_08680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I07_08710	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I07_08735	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_08755	COG3189	MarR family transcriptional regulator
I6I07_08785	COG0640	Transcriptional regulator
I6I07_08845	COG1846	Transcriptional regulator
I6I07_08850	COG1764	response to oxidative stress
I6I07_08875	COG0583	DNA-binding transcription factor activity
I6I07_08890	COG0583	DNA-binding transcription factor activity
I6I07_08900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I07_08905	COG0708	Exodeoxyribonuclease III
I6I07_08910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I07_08925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I07_08930	COG0154	amidase activity
I6I07_08935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I07_08940	COG1077	Cell shape determining protein MreB Mrl
I6I07_08945	COG1792	Involved in formation and maintenance of cell shape
I6I07_08955	COG0768	penicillin binding
I6I07_08960	COG0772	Belongs to the SEDS family
I6I07_08965	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I07_08970	COG0471	metal ion transport
I6I07_08975	COG1309	transcriptional regulator
I6I07_08985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I07_08995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I07_09005	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6I07_09010	COG0792	nuclease activity
I6I07_09020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I07_09030	COG1660	Displays ATPase and GTPase activities
I6I07_09045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I07_09050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6I07_09060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I07_09065	COG1137	ATPase activity
I6I07_09090	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I07_09105	COG1294	oxidase, subunit
I6I07_09115	COG4988	ABC transporter
I6I07_09120	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I07_09125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I07_09140	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I07_09145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I07_09150	COG1238	metal cluster binding
I6I07_09165	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_09170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I07_09175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I07_09180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_09195	COG0758	DNA mediated transformation
I6I07_09200	COG0242	peptide deformylase activity
I6I07_09205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I07_09215	COG0546	phosphoglycolate phosphatase activity
I6I07_09235	COG1733	regulation of RNA biosynthetic process
I6I07_09245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I07_09250	COG1280	lysine exporter protein (LysE YggA)
I6I07_09255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I07_09255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I07_09265	COG5000	phosphorelay sensor kinase activity
I6I07_09270	COG2204	response regulator
I6I07_09275	COG0569	domain protein
I6I07_09280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I07_09285	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6I07_09290	COG2226	methyltransferase
I6I07_09295	COG1040	competence protein
I6I07_09305	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_09310	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I07_09315	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6I07_09320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I07_09325	COG1054	Belongs to the UPF0176 family
I6I07_09330	COG0588	phosphoglycerate mutase activity
I6I07_09340	COG0793	Belongs to the peptidase S41A family
I6I07_09345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I07_09350	COG5001	Diguanylate cyclase
I6I07_09350	COG3300	MHYT domain
I6I07_09355	COG2186	Transcriptional regulator
I6I07_09370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I07_09370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I07_09385	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I07_09390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I07_09395	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I07_09400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I07_09405	COG0142	geranyltranstransferase activity
I6I07_09430	COG2986	histidine ammonia-lyase
I6I07_09495	COG0235	Class ii aldolase
I6I07_09500	COG3622	Belongs to the hyi family
I6I07_09505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I07_09510	COG2084	Dehydrogenase
I6I07_09515	COG3395	kinase activity
I6I07_09520	COG2186	Transcriptional regulator
I6I07_09545	COG3622	Belongs to the hyi family
I6I07_09565	COG1522	sequence-specific DNA binding
I6I07_09570	COG1280	lysine exporter protein (LysE YggA)
I6I07_09585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I07_09590	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I07_09595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I07_09610	COG1464	Belongs to the NlpA lipoprotein family
I6I07_09630	COG0318	PFAM AMP-dependent synthetase and ligase
I6I07_09655	COG0477	Major facilitator Superfamily
I6I07_09660	COG0583	DNA-binding transcription factor activity
I6I07_09670	COG0583	DNA-binding transcription factor activity
I6I07_09690	COG0625	glutathione transferase activity
I6I07_09695	COG1053	succinate dehydrogenase
I6I07_09700	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_09705	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_09725	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I07_09735	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_09740	COG1802	Transcriptional regulator
I6I07_09745	COG0288	reversible hydration of carbon dioxide
I6I07_09765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I07_09775	COG4829	muconolactone delta-isomerase
I6I07_09780	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I07_09790	COG1414	Transcriptional regulator
I6I07_09795	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_09800	COG2031	fatty acid transporter
I6I07_09805	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I07_09810	COG4774	siderophore transport
I6I07_09815	COG3712	iron ion homeostasis
I6I07_09820	COG1595	DNA-templated transcription, initiation
I6I07_09825	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I07_09830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I07_09850	COG0583	DNA-binding transcription factor activity
I6I07_09855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I07_09865	COG0129	dihydroxy-acid dehydratase activity
I6I07_09870	COG0583	DNA-binding transcription factor activity
I6I07_09875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I07_09880	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I07_09885	COG0346	lactoylglutathione lyase activity
I6I07_09890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I07_09895	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_09900	COG0410	ABC transporter
I6I07_09925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I07_09935	COG2186	Transcriptional regulator
I6I07_09945	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I6I07_09970	COG0583	DNA-binding transcription factor activity
I6I07_09975	COG0628	permease
I6I07_09985	COG0477	Major facilitator Superfamily
I6I07_10000	COG1695	Transcriptional regulator
I6I07_10010	COG0583	DNA-binding transcription factor activity
I6I07_10155	COG0583	DNA-binding transcription factor activity
I6I07_10160	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_10170	COG3246	L-lysine catabolic process to acetate
I6I07_10175	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I07_10180	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I07_10200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I07_10210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_10235	COG2233	PERMEase
I6I07_10245	COG0326	Molecular chaperone. Has ATPase activity
I6I07_10250	COG1396	sequence-specific DNA binding
I6I07_10255	COG3550	peptidyl-serine autophosphorylation
I6I07_10260	COG2814	Major facilitator Superfamily
I6I07_10265	COG4774	siderophore transport
I6I07_10280	COG1131	(ABC) transporter
I6I07_10285	COG2271	Major facilitator Superfamily
I6I07_10290	COG4948	Mandelate Racemase Muconate Lactonizing
I6I07_10295	COG0800	Aldolase
I6I07_10305	COG1414	Transcriptional regulator
I6I07_10350	COG0583	DNA-binding transcription factor activity
I6I07_10355	COG1012	belongs to the aldehyde dehydrogenase family
I6I07_10385	COG0625	glutathione transferase activity
I6I07_10400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I07_10405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I07_10410	COG1652	LysM domain
I6I07_10425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I07_10430	COG0583	DNA-binding transcription factor activity
I6I07_10435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I07_10440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I07_10510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I07_10540	COG3246	L-lysine catabolic process to acetate
I6I07_10545	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_10555	COG2205	protein histidine kinase activity
I6I07_10565	COG2205	protein histidine kinase activity
I6I07_10565	COG2198	Histidine kinase
I6I07_10565	COG0784	Response regulator, receiver
I6I07_10575	COG0165	Argininosuccinate lyase
I6I07_10585	COG2828	Protein conserved in bacteria
I6I07_10600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I07_10610	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I07_10650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I07_10665	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I07_10675	COG1234	tRNA 3'-trailer cleavage
I6I07_10685	COG0625	glutathione transferase activity
I6I07_10695	COG3258	Cytochrome c
I6I07_10730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I07_10740	COG1294	oxidase, subunit
I6I07_10745	COG1271	oxidase subunit
I6I07_10750	COG1942	4-Oxalocrotonate Tautomerase
I6I07_10755	COG0697	spore germination
I6I07_10765	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_10775	COG0842	Transport permease protein
I6I07_10780	COG0842	Transport permease protein
I6I07_10780	COG1129	ABC transporter
I6I07_10785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I07_10795	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6I07_10805	COG4774	siderophore transport
I6I07_10815	COG1595	DNA-templated transcription, initiation
I6I07_10820	COG2200	EAL domain
I6I07_10840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I07_10845	COG0745	RESPONSE REGULATOR receiver
I6I07_10855	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I07_10855	COG2755	lipolytic protein G-D-S-L family
I6I07_10870	COG1054	Belongs to the UPF0176 family
I6I07_10875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I07_10875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I07_10885	COG0489	protein tyrosine kinase activity
I6I07_10900	COG0717	Belongs to the dCTP deaminase family
I6I07_10910	COG3706	GGDEF domain
I6I07_10930	COG2081	HI0933 family
I6I07_10945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I07_10950	COG0509	glycine decarboxylation via glycine cleavage system
I6I07_10955	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I07_10955	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I07_10970	COG0154	amidase activity
I6I07_10975	COG4172	Belongs to the ABC transporter superfamily
I6I07_10980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_10985	COG0601	transmembrane transport
I6I07_10990	COG0747	negative chemotaxis
I6I07_11005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I07_11010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I07_11035	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6I07_11040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I07_11045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I07_11060	COG0438	transferase activity, transferring glycosyl groups
I6I07_11070	COG0438	transferase activity, transferring glycosyl groups
I6I07_11075	COG0438	transferase activity, transferring glycosyl groups
I6I07_11080	COG0438	transferase activity, transferring glycosyl groups
I6I07_11085	COG0405	Gamma-glutamyltransferase
I6I07_11090	COG0166	Belongs to the GPI family
I6I07_11105	COG0277	FAD linked oxidase domain protein
I6I07_11110	COG0745	RESPONSE REGULATOR receiver
I6I07_11115	COG2205	protein histidine kinase activity
I6I07_11125	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I07_11125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I07_11135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I07_11145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I07_11150	COG2186	Transcriptional regulator
I6I07_11155	COG1368	sulfuric ester hydrolase activity
I6I07_11160	COG0204	Acyl-transferase
I6I07_11195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I07_11210	COG0840	transmembrane signaling receptor activity
I6I07_11215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I07_11245	COG0012	GTP binding
I6I07_11250	COG0582	viral genome integration into host DNA
I6I07_11255	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6I07_11280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I07_11285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I07_11300	COG0488	(ABC) transporter
I6I07_11315	COG2814	Major facilitator Superfamily
I6I07_11330	COG3135	benzoate transporter
I6I07_11335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I07_11340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I07_11345	COG0742	ribosomal rna small subunit methyltransferase
I6I07_11365	COG3639	organic phosphonate transmembrane transporter activity
I6I07_11370	COG3639	organic phosphonate transmembrane transporter activity
I6I07_11375	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I07_11400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I07_11405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I07_11420	COG1058	Belongs to the CinA family
I6I07_11420	COG1546	Belongs to the CinA family
I6I07_11425	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I07_11430	COG1252	NADH dehydrogenase
I6I07_11435	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I07_11440	COG0246	Mannitol dehydrogenase
I6I07_11450	COG1137	ATPase activity
I6I07_11475	COG1917	Cupin 2, conserved barrel domain protein
I6I07_11495	COG4774	siderophore transport
I6I07_11510	COG1846	Transcriptional regulator
I6I07_11520	COG0459	protein refolding
I6I07_11525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I07_11540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I07_11545	COG4172	Belongs to the ABC transporter superfamily
I6I07_11550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_11555	COG0601	transmembrane transport
I6I07_11570	COG0583	DNA-binding transcription factor activity
I6I07_11575	COG1132	(ABC) transporter
I6I07_11620	COG1136	(ABC) transporter
I6I07_11620	COG0577	efflux transmembrane transporter activity
I6I07_11635	COG0745	RESPONSE REGULATOR receiver
I6I07_11640	COG2205	protein histidine kinase activity
I6I07_11645	COG0745	RESPONSE REGULATOR receiver
I6I07_11695	COG2186	Transcriptional regulator
I6I07_11705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I07_11730	COG0372	Belongs to the citrate synthase family
I6I07_11745	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_11750	COG2207	Transcriptional regulator
I6I07_11760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I07_11765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I07_11770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I07_11785	COG0583	DNA-binding transcription factor activity
I6I07_11800	COG0243	molybdopterin cofactor binding
I6I07_11805	COG0038	chloride channel
I6I07_11815	COG4191	Histidine kinase
I6I07_11820	COG2204	response regulator
I6I07_11840	COG2200	EAL domain
I6I07_11845	COG2814	Major facilitator Superfamily
I6I07_11855	COG0300	oxidoreductase activity
I6I07_11870	COG2375	cellular response to nickel ion
I6I07_11870	COG1132	(ABC) transporter
I6I07_11875	COG1132	(ABC) transporter
I6I07_11880	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I07_11885	COG4605	iron ion homeostasis
I6I07_11890	COG4604	ABC transporter, ATP-binding protein
I6I07_11895	COG4607	ABC-type enterochelin transport system periplasmic component
I6I07_11900	COG4774	siderophore transport
I6I07_11925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I07_11975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I07_11985	COG0745	RESPONSE REGULATOR receiver
I6I07_12015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I07_12030	COG0277	FAD linked oxidase domain protein
I6I07_12045	COG0793	Belongs to the peptidase S41A family
I6I07_12070	COG1595	DNA-templated transcription, initiation
I6I07_12085	COG1595	DNA-templated transcription, initiation
I6I07_12095	COG0698	ribose 5-phosphate isomerase
I6I07_12105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_12110	COG4597	amino acid ABC transporter
I6I07_12115	COG0765	amino acid transport
I6I07_12120	COG1126	abc transporter atp-binding protein
I6I07_12140	COG4772	TonB-dependent receptor
I6I07_12145	COG3712	iron ion homeostasis
I6I07_12150	COG1595	DNA-templated transcription, initiation
I6I07_12155	COG1073	alpha beta
I6I07_12195	COG0583	DNA-binding transcription factor activity
I6I07_12200	COG0697	spore germination
I6I07_12235	COG0431	NADPH-dependent FMN reductase
I6I07_12240	COG0798	PFAM Bile acid sodium symporter
I6I07_12275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_12335	COG1793	dna ligase
I6I07_12335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6I07_12340	COG1793	dna ligase
I6I07_12345	COG1201	RNA secondary structure unwinding
I6I07_12355	COG1132	(ABC) transporter
I6I07_12355	COG2375	cellular response to nickel ion
I6I07_12370	COG4771	TonB-dependent receptor
I6I07_12420	COG1309	transcriptional regulator
I6I07_12425	COG0028	Belongs to the TPP enzyme family
I6I07_12475	COG0583	DNA-binding transcription factor activity
I6I07_12480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I07_12490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I07_12510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I07_12530	COG2814	Major facilitator Superfamily
I6I07_12535	COG0740	serine-type endopeptidase activity
I6I07_12545	COG0640	Transcriptional regulator
I6I07_12550	COG2199	diguanylate cyclase activity
I6I07_12550	COG2203	Gaf domain
I6I07_12555	COG0840	transmembrane signaling receptor activity
I6I07_12580	COG4948	Mandelate Racemase Muconate Lactonizing
I6I07_12585	COG0583	DNA-binding transcription factor activity
I6I07_12590	COG0456	acetyltransferase
I6I07_12600	COG0023	Translation Initiation Factor
I6I07_12605	COG0583	DNA-binding transcription factor activity
I6I07_12610	COG0656	L-ascorbic acid biosynthetic process
I6I07_12620	COG0667	Aldo Keto reductase
I6I07_12630	COG0243	molybdopterin cofactor binding
I6I07_12635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I07_12635	COG2146	nitrite reductase [NAD(P)H] activity
I6I07_12640	COG2146	nitrite reductase [NAD(P)H] activity
I6I07_12640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I07_12645	COG3707	response regulator
I6I07_12675	COG2197	response regulator
I6I07_12700	COG0625	glutathione transferase activity
I6I07_12715	COG2814	Major facilitator Superfamily
I6I07_12725	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I07_12730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I07_12740	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I07_12745	COG1845	cytochrome c oxidase, subunit III
I6I07_12750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I07_12755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I07_12760	COG0477	Major facilitator Superfamily
I6I07_12770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_12775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I07_12815	COG0583	DNA-binding transcription factor activity
I6I07_12830	COG4106	trans-aconitate 2-methyltransferase activity
I6I07_12835	COG2207	Transcriptional regulator
I6I07_12840	COG2807	transmembrane transport
I6I07_12860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I07_12870	COG0330	HflC and HflK could
I6I07_12875	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I07_12890	COG3712	iron ion homeostasis
I6I07_12900	COG4221	oxidoreductase activity
I6I07_12915	COG3712	iron ion homeostasis
I6I07_12925	COG1595	DNA-templated transcription, initiation
I6I07_12930	COG3712	iron ion homeostasis
I6I07_12945	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I07_12960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I07_12965	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_12970	COG1285	pathogenesis
I6I07_12975	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6I07_12990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I07_13015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I07_13020	COG1396	sequence-specific DNA binding
I6I07_13040	COG0583	DNA-binding transcription factor activity
I6I07_13080	COG0697	spore germination
I6I07_13085	COG2207	Transcriptional regulator
I6I07_13085	COG1917	Cupin 2, conserved barrel domain protein
I6I07_13095	COG0281	malic enzyme
I6I07_13095	COG0280	phosphate acetyltransferase
I6I07_13115	COG4772	TonB-dependent receptor
I6I07_13135	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I07_13140	COG1845	cytochrome c oxidase, subunit III
I6I07_13145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I07_13155	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6I07_13175	COG1999	signal sequence binding
I6I07_13200	COG1126	abc transporter atp-binding protein
I6I07_13205	COG0765	amino acid transport
I6I07_13210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_13215	COG3191	aminopeptidase activity
I6I07_13220	COG1272	protein, Hemolysin III
I6I07_13225	COG1522	sequence-specific DNA binding
I6I07_13235	COG1113	amino acid transport
I6I07_13240	COG0583	DNA-binding transcription factor activity
I6I07_13265	COG2378	regulation of single-species biofilm formation
I6I07_13295	COG1595	DNA-templated transcription, initiation
I6I07_13300	COG3712	iron ion homeostasis
I6I07_13310	COG3720	iron ion transport
I6I07_13315	COG4558	Periplasmic binding protein
I6I07_13320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I07_13325	COG1120	ATPase activity
I6I07_13330	COG1666	GTP binding
I6I07_13345	COG0671	phosphoesterase, PA-phosphatase related
I6I07_13355	COG4585	Histidine kinase
I6I07_13375	COG4774	siderophore transport
I6I07_13400	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I07_13440	COG0456	acetyltransferase
I6I07_13445	COG0583	DNA-binding transcription factor activity
I6I07_13450	COG2828	Protein conserved in bacteria
I6I07_13470	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_13485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I07_13520	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I07_13525	COG0583	DNA-binding transcription factor activity
I6I07_13550	COG2223	nitrite transmembrane transporter activity
I6I07_13560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I07_13565	COG3383	formate dehydrogenase (NAD+) activity
I6I07_13585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I07_13590	COG0746	molybdenum cofactor guanylyltransferase activity
I6I07_13595	COG0303	'Molybdopterin
I6I07_13600	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I07_13605	COG0314	molybdopterin synthase activity
I6I07_13615	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I07_13625	COG0412	Dienelactone hydrolase
I6I07_13635	COG0678	peroxiredoxin activity
I6I07_13645	COG0697	spore germination
I6I07_13690	COG0667	Aldo Keto reductase
I6I07_13695	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I07_13700	COG4535	Mg2 and Co2 transporter CorC
I6I07_13705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I07_13710	COG1702	phosphate starvation-inducible protein PhoH
I6I07_13715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I07_13725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I07_13745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I07_13750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I07_13755	COG1862	Preprotein translocase
I6I07_13760	COG0343	queuine tRNA-ribosyltransferase activity
I6I07_13765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I07_13780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I07_13795	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I07_13800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I07_13805	COG1648	precorrin-2 dehydrogenase activity
I6I07_13805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I07_13810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I07_13820	COG1116	anion transmembrane transporter activity
I6I07_13830	COG4575	ribosome binding
I6I07_13855	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6I07_13860	COG0741	lytic transglycosylase activity
I6I07_13870	COG0436	Aminotransferase
I6I07_13880	COG0280	phosphate acetyltransferase
I6I07_13880	COG0281	malic enzyme
I6I07_13890	COG2732	(Barnase) inhibitor
I6I07_13895	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I07_13905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I07_13910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I07_13915	COG0126	phosphoglycerate kinase activity
I6I07_13930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I07_13935	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I07_13955	COG0625	glutathione transferase activity
I6I07_13975	COG0789	Transcriptional regulator
I6I07_13990	COG0306	phosphate transporter
I6I07_14000	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I07_14010	COG0739	heme binding
I6I07_14020	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I07_14030	COG0640	Transcriptional regulator
I6I07_14040	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I07_14045	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6I07_14050	COG3639	organic phosphonate transmembrane transporter activity
I6I07_14070	COG0583	DNA-binding transcription factor activity
I6I07_14075	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6I07_14080	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6I07_14085	COG3454	Phosphonate metabolism
I6I07_14090	COG2188	Transcriptional regulator
I6I07_14095	COG3624	Phosphonate C-P lyase system protein PhnG
I6I07_14100	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6I07_14105	COG3626	phosphonate metabolism
I6I07_14110	COG3627	carbon phosphorus lyase activity
I6I07_14115	COG4107	phosphonate C-P lyase system protein PhnK
I6I07_14120	COG4778	phosphonate C-P lyase system protein PhnL
I6I07_14125	COG3454	Phosphonate metabolism
I6I07_14140	COG1301	dicarboxylic acid transport
I6I07_14155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I07_14170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_14175	COG4172	Belongs to the ABC transporter superfamily
I6I07_14195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I07_14205	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I07_14210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I07_14215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I07_14220	COG0009	L-threonylcarbamoyladenylate synthase
I6I07_14225	COG1414	Transcriptional regulator
I6I07_14230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I07_14245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_14250	COG1414	Transcriptional regulator
I6I07_14255	COG0010	Belongs to the arginase family
I6I07_14265	COG0765	amino acid transport
I6I07_14270	COG1126	abc transporter atp-binding protein
I6I07_14275	COG0028	Belongs to the TPP enzyme family
I6I07_14320	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I07_14365	COG0028	Belongs to the TPP enzyme family
I6I07_14370	COG0583	DNA-binding transcription factor activity
I6I07_14375	COG4974	Belongs to the 'phage' integrase family
I6I07_14380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I07_14400	COG0583	DNA-binding transcription factor activity
I6I07_14410	COG3842	ATPase activity
I6I07_14415	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I07_14430	COG1686	Belongs to the peptidase S11 family
I6I07_14445	COG0318	PFAM AMP-dependent synthetase and ligase
I6I07_14450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I07_14460	COG1024	Enoyl-CoA hydratase
I6I07_14465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I07_14485	COG2070	2-Nitropropane dioxygenase
I6I07_14505	COG1074	ATP-dependent DNA helicase activity
I6I07_14515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I07_14530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I07_14535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I07_14545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I07_14560	COG0745	RESPONSE REGULATOR receiver
I6I07_14575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I07_14580	COG0505	Belongs to the CarA family
I6I07_14585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I07_14595	COG4221	oxidoreductase activity
I6I07_14600	COG0406	alpha-ribazole phosphatase activity
I6I07_14610	COG3842	ATPase activity
I6I07_14630	COG2233	PERMEase
I6I07_14635	COG0840	transmembrane signaling receptor activity
I6I07_14640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I07_14645	COG1534	Rna-binding protein
I6I07_14650	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I07_14655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I07_14665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I07_14700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I07_14705	COG2814	Major facilitator Superfamily
I6I07_14725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I07_14735	COG0438	transferase activity, transferring glycosyl groups
I6I07_14750	COG2841	Protein conserved in bacteria
I6I07_14765	COG1595	DNA-templated transcription, initiation
I6I07_14775	COG0583	DNA-binding transcription factor activity
I6I07_14780	COG2207	Transcriptional regulator
I6I07_14785	COG0667	Aldo Keto reductase
I6I07_14810	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I6I07_14815	COG0500	methyltransferase
I6I07_14845	COG0517	IMP dehydrogenase activity
I6I07_14855	COG3938	Belongs to the proline racemase family
I6I07_14860	COG1177	transmembrane transport
I6I07_14870	COG3842	ATPase activity
I6I07_14930	COG1511	domain protein
I6I07_14930	COG3264	Mechanosensitive ion channel
I6I07_14935	COG0583	DNA-binding transcription factor activity
I6I07_14940	COG0427	acetyl-CoA hydrolase
I6I07_14945	COG0583	DNA-binding transcription factor activity
I6I07_14985	COG0235	Class ii aldolase
I6I07_14995	COG0583	DNA-binding transcription factor activity
I6I07_15010	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I07_15020	COG0477	Major facilitator Superfamily
I6I07_15030	COG0154	amidase activity
I6I07_15050	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I07_15065	COG0495	leucyl-tRNA aminoacylation
I6I07_15070	COG2814	Major facilitator Superfamily
I6I07_15075	COG1846	Transcriptional regulator
I6I07_15085	COG1686	Belongs to the peptidase S11 family
I6I07_15120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I07_15125	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I07_15130	COG2814	Major facilitator Superfamily
I6I07_15135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I07_15145	COG4176	ABC-type proline glycine betaine transport system permease component
I6I07_15160	COG1609	Transcriptional regulator
I6I07_15165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I07_15170	COG2706	6-phosphogluconolactonase activity
I6I07_15175	COG4214	carbohydrate transport
I6I07_15180	COG1129	ABC transporter
I6I07_15185	COG4213	ABC transporter substrate-binding protein
I6I07_15195	COG0183	Belongs to the thiolase family
I6I07_15205	COG1802	Transcriptional regulator
I6I07_15215	COG1024	Enoyl-CoA hydratase
I6I07_15220	COG0318	PFAM AMP-dependent synthetase and ligase
I6I07_15230	COG1595	DNA-templated transcription, initiation
I6I07_15235	COG3712	iron ion homeostasis
I6I07_15245	COG0667	Aldo Keto reductase
I6I07_15255	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6I07_15260	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I07_15270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I07_15280	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I07_15305	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6I07_15310	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I07_15315	COG4149	molybdate abc transporter
I6I07_15320	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6I07_15345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I07_15350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I07_15360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I07_15365	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I07_15380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I07_15390	COG0473	3-isopropylmalate dehydrogenase activity
I6I07_15395	COG0583	DNA-binding transcription factor activity
I6I07_15400	COG1858	cytochrome C peroxidase
I6I07_15405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I07_15405	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I07_15410	COG2224	Isocitrate lyase
I6I07_15425	COG4106	trans-aconitate 2-methyltransferase activity
I6I07_15425	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6I07_15435	COG0156	8-amino-7-oxononanoate synthase activity
I6I07_15455	COG3278	Belongs to the heme-copper respiratory oxidase family
I6I07_15475	COG0348	domain, Protein
I6I07_15495	COG1012	belongs to the aldehyde dehydrogenase family
I6I07_15500	COG1126	abc transporter atp-binding protein
I6I07_15505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_15515	COG0765	amino acid transport
I6I07_15520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I07_15550	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6I07_15560	COG0438	transferase activity, transferring glycosyl groups
I6I07_15575	COG1538	Outer membrane efflux protein
I6I07_15580	COG1566	PFAM secretion protein HlyD family protein
I6I07_15595	COG0583	DNA-binding transcription factor activity
I6I07_15600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I07_15605	COG0586	Pfam SNARE associated Golgi protein
I6I07_15610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I07_15625	COG4608	Belongs to the ABC transporter superfamily
I6I07_15630	COG0444	Belongs to the ABC transporter superfamily
I6I07_15635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_15640	COG0601	transmembrane transport
I6I07_15645	COG0583	DNA-binding transcription factor activity
I6I07_15650	COG0300	oxidoreductase activity
I6I07_15655	COG1764	response to oxidative stress
I6I07_15660	COG2205	protein histidine kinase activity
I6I07_15690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I07_15705	COG1802	Transcriptional regulator
I6I07_15720	COG1595	DNA-templated transcription, initiation
I6I07_15730	COG4774	siderophore transport
I6I07_15740	COG2084	Dehydrogenase
I6I07_15750	COG2207	Transcriptional regulator
I6I07_15750	COG1917	Cupin 2, conserved barrel domain protein
I6I07_15760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I07_16045	COG1196	nuclear chromosome segregation
I6I07_16140	COG1280	lysine exporter protein (LysE YggA)
I6I07_16145	COG1522	sequence-specific DNA binding
I6I07_16160	COG1280	lysine exporter protein (LysE YggA)
I6I07_16190	COG4774	siderophore transport
I6I07_16195	COG3712	iron ion homeostasis
I6I07_16200	COG1595	DNA-templated transcription, initiation
I6I07_16205	COG0840	transmembrane signaling receptor activity
I6I07_16210	COG3121	Chaperone
I6I07_16215	COG3188	usher protein
I6I07_16235	COG0642	Histidine kinase
I6I07_16240	COG1475	DNA binding
I6I07_16250	COG3969	phosphoadenosine phosphosulfate
I6I07_16255	COG1971	Probably functions as a manganese efflux pump
I6I07_16260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I07_16320	COG2321	neutral zinc metallopeptidase
I6I07_16325	COG0009	L-threonylcarbamoyladenylate synthase
I6I07_16330	COG1994	Peptidase M50
I6I07_16335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I07_16340	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6I07_16355	COG2850	peptidyl-arginine hydroxylation
I6I07_16360	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I07_16400	COG0583	DNA-binding transcription factor activity
I6I07_16440	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_16445	COG0583	DNA-binding transcription factor activity
I6I07_16455	COG3360	Dodecin
I6I07_16490	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I07_16495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I07_16500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I07_16540	COG0668	transmembrane transport
I6I07_16560	COG0483	inositol monophosphate 1-phosphatase activity
I6I07_16565	COG4804	nuclease activity
I6I07_16570	COG1477	protein flavinylation
I6I07_16580	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6I07_16595	COG4263	nitrous-oxide reductase activity
I6I07_16610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I07_16615	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I07_16625	COG1253	flavin adenine dinucleotide binding
I6I07_16630	COG1968	undecaprenyl-diphosphatase activity
I6I07_16635	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I07_16650	COG0215	cysteine-tRNA ligase activity
I6I07_16660	COG0825	malonyl-CoA metabolic process
I6I07_16670	COG0527	aspartate kinase activity
I6I07_16680	COG4695	Portal protein
I6I07_16690	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I07_16695	COG0784	Response regulator, receiver
I6I07_16695	COG2205	protein histidine kinase activity
I6I07_16700	COG2199	diguanylate cyclase activity
I6I07_16700	COG2200	EAL domain
I6I07_16700	COG2202	Pas domain
I6I07_16705	COG2205	protein histidine kinase activity
I6I07_16705	COG0784	Response regulator, receiver
I6I07_16710	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6I07_16720	COG1309	transcriptional regulator
I6I07_16725	COG1116	anion transmembrane transporter activity
I6I07_16765	COG0583	DNA-binding transcription factor activity
I6I07_16790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I07_16800	COG1414	Transcriptional regulator
I6I07_16810	COG1024	Enoyl-CoA hydratase
I6I07_16815	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I07_16820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I07_16830	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I07_16835	COG3395	kinase activity
I6I07_16845	COG1132	(ABC) transporter
I6I07_16855	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_16865	COG0318	PFAM AMP-dependent synthetase and ligase
I6I07_16880	COG0183	Belongs to the thiolase family
I6I07_16885	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I07_16885	COG1024	Enoyl-CoA hydratase
I6I07_16895	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I07_16895	COG1024	Enoyl-CoA hydratase
I6I07_16905	COG1960	acyl-CoA dehydrogenase activity
I6I07_16910	COG1309	transcriptional regulator
I6I07_16920	COG2197	response regulator
I6I07_16925	COG2197	response regulator
I6I07_16930	COG0297	glycogen (starch) synthase activity
I6I07_16935	COG0110	maltose O-acetyltransferase activity
I6I07_16940	COG0463	Glycosyl transferase, family 2
I6I07_16945	COG0438	transferase activity, transferring glycosyl groups
I6I07_16965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I07_17010	COG0166	Belongs to the GPI family
I6I07_17015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I07_17020	COG1045	serine acetyltransferase
I6I07_17025	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I07_17040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I07_17055	COG0210	DNA helicase
I6I07_17060	COG0598	Magnesium transport protein CorA
I6I07_17075	COG0601	transmembrane transport
I6I07_17080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_17085	COG4172	Belongs to the ABC transporter superfamily
I6I07_17095	COG1846	Transcriptional regulator
I6I07_17140	COG4964	Belongs to the GSP D family
I6I07_17195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I07_17210	COG3384	dioxygenase
I6I07_17220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I07_17240	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_17245	COG3321	synthase
I6I07_17245	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_17245	COG0604	alcohol dehydrogenase
I6I07_17260	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I07_17270	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_17275	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I07_17280	COG3246	L-lysine catabolic process to acetate
I6I07_17285	COG0371	Dehydrogenase
I6I07_17290	COG1802	Transcriptional regulator
I6I07_17295	COG3959	Transketolase, thiamine diphosphate binding domain
I6I07_17300	COG3958	Transketolase
I6I07_17305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I07_17315	COG4948	Mandelate Racemase Muconate Lactonizing
I6I07_17320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_17330	COG0765	amino acid transport
I6I07_17340	COG2721	sulfolactate sulfo-lyase activity
I6I07_17350	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_17355	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I07_17360	COG1414	Transcriptional regulator
I6I07_17385	COG2188	Transcriptional regulator
I6I07_17390	COG0596	Alpha beta hydrolase
I6I07_17410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I07_17420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I07_17425	COG1120	ATPase activity
I6I07_17440	COG4771	TonB-dependent receptor
I6I07_17465	COG5295	Hep Hag repeat protein
I6I07_17500	COG0477	Major facilitator Superfamily
I6I07_17510	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I07_17520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I07_17540	COG1113	amino acid transport
I6I07_17550	COG1640	4-alpha-glucanotransferase
I6I07_17555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I07_17565	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I07_17570	COG0366	Alpha amylase catalytic
I6I07_17575	COG0366	Alpha amylase catalytic
I6I07_17580	COG0297	glycogen (starch) synthase activity
I6I07_17585	COG0392	lysyltransferase activity
I6I07_17590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I07_17595	COG3568	Endonuclease Exonuclease Phosphatase
I6I07_17600	COG0387	Pfam Sodium calcium exchanger
I6I07_17615	COG3685	Protein conserved in bacteria
I6I07_17625	COG0166	Belongs to the GPI family
I6I07_17635	COG0668	transmembrane transport
I6I07_17665	COG1064	alcohol dehydrogenase
I6I07_17680	COG1850	ribulose-bisphosphate carboxylase activity
I6I07_17690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I07_17695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I07_17700	COG1609	Transcriptional regulator
I6I07_17730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I07_17755	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_17760	COG0625	glutathione transferase activity
I6I07_17770	COG1396	sequence-specific DNA binding
I6I07_17860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I07_17880	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6I07_17885	COG1116	anion transmembrane transporter activity
I6I07_17890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I07_17895	COG1116	anion transmembrane transporter activity
I6I07_17895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I07_17900	COG2197	response regulator
I6I07_17910	COG1131	(ABC) transporter
I6I07_17915	COG0842	Transport permease protein
I6I07_17930	COG0183	Belongs to the thiolase family
I6I07_17955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I07_17970	COG0604	alcohol dehydrogenase
I6I07_17970	COG3321	synthase
I6I07_17985	COG4638	Rieske (2fe-2S)
I6I07_18015	COG1278	Cold shock
I6I07_18025	COG1272	protein, Hemolysin III
I6I07_18055	COG2169	Transcriptional regulator
I6I07_18075	COG0583	DNA-binding transcription factor activity
I6I07_18085	COG4172	Belongs to the ABC transporter superfamily
I6I07_18090	COG0402	S-adenosylhomocysteine deaminase activity
I6I07_18095	COG0747	negative chemotaxis
I6I07_18100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_18120	COG1595	DNA-templated transcription, initiation
I6I07_18125	COG2814	Major facilitator Superfamily
I6I07_18130	COG0583	DNA-binding transcription factor activity
I6I07_18170	COG4126	flavin adenine dinucleotide binding
I6I07_18185	COG2837	iron assimilation
I6I07_18215	COG0583	DNA-binding transcription factor activity
I6I07_18220	COG2814	Major facilitator Superfamily
I6I07_18225	COG0583	DNA-binding transcription factor activity
I6I07_18240	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I07_18255	COG2814	Major facilitator Superfamily
I6I07_18265	COG1464	Belongs to the NlpA lipoprotein family
I6I07_18270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I07_18275	COG2011	ABC-type metal ion transport system permease component
I6I07_18310	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_18315	COG3618	amidohydrolase
I6I07_18320	COG0583	DNA-binding transcription factor activity
I6I07_18330	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6I07_18335	COG3153	acetyltransferase
I6I07_18345	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_18350	COG1473	amidohydrolase
I6I07_18360	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_18375	COG0583	DNA-binding transcription factor activity
I6I07_18390	COG2951	lytic endotransglycosylase activity
I6I07_18395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I07_18400	COG0519	Catalyzes the synthesis of GMP from XMP
I6I07_18430	COG0519	Catalyzes the synthesis of GMP from XMP
I6I07_18440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_18455	COG4172	Belongs to the ABC transporter superfamily
I6I07_18465	COG1522	sequence-specific DNA binding
I6I07_18485	COG3706	GGDEF domain
I6I07_18520	COG0625	glutathione transferase activity
I6I07_18535	COG3530	Putative quorum-sensing-regulated virulence factor
I6I07_18545	COG2814	Major facilitator Superfamily
I6I07_18580	COG0443	Heat shock 70 kDa protein
I6I07_18585	COG0583	DNA-binding transcription factor activity
I6I07_18605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I07_18610	COG0477	Major facilitator Superfamily
I6I07_18620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I07_18630	COG0542	response to heat
I6I07_18655	COG5441	Belongs to the UPF0261 family
I6I07_18660	COG5564	TIM-barrel signal transduction protein
I6I07_18675	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I07_18690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I07_18700	COG1562	ergosterol biosynthetic process
I6I07_18710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I07_18715	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_18725	COG3971	2-oxopent-4-enoate hydratase activity
I6I07_18740	COG1012	belongs to the aldehyde dehydrogenase family
I6I07_18745	COG3384	dioxygenase
I6I07_18775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I07_18785	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_18795	COG2186	Transcriptional regulator
I6I07_18800	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I07_18805	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_18820	COG0583	DNA-binding transcription factor activity
I6I07_18825	COG0268	Binds directly to 16S ribosomal RNA
I6I07_18835	COG0728	peptidoglycan biosynthetic process
I6I07_18845	COG0563	adenylate kinase activity
I6I07_18850	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I07_18855	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I07_18865	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I07_18875	COG0811	peptide transport
I6I07_18880	COG1570	exodeoxyribonuclease VII activity
I6I07_18890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I07_18900	COG0038	chloride channel
I6I07_18905	COG0183	Belongs to the thiolase family
I6I07_18915	COG1278	Cold shock
I6I07_18920	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I07_18925	COG2373	Large extracellular alpha-helical protein
I6I07_18930	COG4953	penicillin-binding protein 1C
I6I07_18940	COG2995	paraquat-inducible protein a
I6I07_18945	COG3008	intermembrane lipid transfer
I6I07_18955	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I07_18955	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I07_18955	COG0506	proline dehydrogenase activity
I6I07_18990	COG2271	Major facilitator Superfamily
I6I07_19010	COG1289	transmembrane transporter activity
I6I07_19020	COG1566	PFAM secretion protein HlyD family protein
I6I07_19030	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I07_19035	COG1764	response to oxidative stress
I6I07_19050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_19055	COG0765	amino acid transport
I6I07_19060	COG0765	amino acid transport
I6I07_19065	COG1126	abc transporter atp-binding protein
I6I07_19070	COG1902	pentaerythritol trinitrate reductase activity
I6I07_19120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I07_19125	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I07_19130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I07_19135	COG0196	riboflavin kinase activity
I6I07_19140	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I07_19145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I07_19145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I07_19160	COG0210	DNA helicase
I6I07_19170	COG1858	cytochrome C peroxidase
I6I07_19180	COG4771	TonB-dependent receptor
I6I07_19195	COG4771	TonB-dependent receptor
I6I07_19200	COG4771	TonB-dependent receptor
I6I07_19215	COG0488	(ABC) transporter
I6I07_19220	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I07_19230	COG2171	N-acyltransferase activity
I6I07_19245	COG0582	viral genome integration into host DNA
I6I07_19315	COG1475	DNA binding
I6I07_19455	COG0740	serine-type endopeptidase activity
I6I07_19630	COG3038	cytochrome b561
I6I07_19635	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6I07_19675	COG0583	DNA-binding transcription factor activity
I6I07_19685	COG0251	oxidation-reduction process
I6I07_19710	COG1278	Cold shock
I6I07_19720	COG1278	Cold shock
I6I07_19730	COG0501	Belongs to the peptidase M48B family
I6I07_19735	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I07_19740	COG0740	serine-type endopeptidase activity
I6I07_19745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I07_19750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I07_19755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I07_19765	COG0556	nucleotide-excision repair
I6I07_19770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I07_19780	COG1104	cysteine desulfurase activity
I6I07_19785	COG0822	iron-sulfur transferase activity
I6I07_19790	COG0316	Belongs to the HesB IscA family
I6I07_19795	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I07_19800	COG0443	Heat shock 70 kDa protein
I6I07_19805	COG0633	Ferredoxin
I6I07_19810	COG2975	iron-sulfur cluster assembly
I6I07_19815	COG1803	Methylglyoxal synthase
I6I07_19825	COG1024	Enoyl-CoA hydratase
I6I07_19855	COG1022	Amp-dependent synthetase and ligase
I6I07_19865	COG1309	transcriptional regulator
I6I07_19875	COG3135	benzoate transporter
I6I07_19890	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I07_19895	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_19905	COG2271	Major facilitator Superfamily
I6I07_19930	COG1136	(ABC) transporter
I6I07_19935	COG0084	hydrolase, TatD family'
I6I07_19945	COG0745	RESPONSE REGULATOR receiver
I6I07_19950	COG4771	TonB-dependent receptor
I6I07_19955	COG4607	ABC-type enterochelin transport system periplasmic component
I6I07_19960	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I07_19965	COG4605	iron ion homeostasis
I6I07_19970	COG4604	ABC transporter, ATP-binding protein
I6I07_19990	COG1595	DNA-templated transcription, initiation
I6I07_20020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I07_20025	COG1116	anion transmembrane transporter activity
I6I07_20030	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_20055	COG2149	membrane
I6I07_20090	COG3119	arylsulfatase activity
I6I07_20100	COG0277	FAD linked oxidase domain protein
I6I07_20120	COG0159	tryptophan synthase activity
I6I07_20140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I07_20145	COG0477	Major facilitator Superfamily
I6I07_20150	COG0583	DNA-binding transcription factor activity
I6I07_20160	COG0583	DNA-binding transcription factor activity
I6I07_20170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I07_20190	COG0613	PHP domain protein
I6I07_20200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I07_20205	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I07_20205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I07_20215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I07_20215	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I07_20240	COG0642	Histidine kinase
I6I07_20260	COG0583	DNA-binding transcription factor activity
I6I07_20275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I07_20285	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_20300	COG0583	DNA-binding transcription factor activity
I6I07_20305	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_20330	COG0745	RESPONSE REGULATOR receiver
I6I07_20335	COG2205	protein histidine kinase activity
I6I07_20335	COG2198	Histidine kinase
I6I07_20335	COG0784	Response regulator, receiver
I6I07_20335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_20340	COG0583	DNA-binding transcription factor activity
I6I07_20355	COG1309	transcriptional regulator
I6I07_20375	COG1953	Uracil, thiamine, allantoin
I6I07_20400	COG0477	Major facilitator Superfamily
I6I07_20440	COG0583	DNA-binding transcription factor activity
I6I07_20470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I07_20475	COG4774	siderophore transport
I6I07_20480	COG3706	GGDEF domain
I6I07_20490	COG4774	siderophore transport
I6I07_20520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I07_20535	COG3618	amidohydrolase
I6I07_20540	COG0583	DNA-binding transcription factor activity
I6I07_20550	COG1960	acyl-CoA dehydrogenase activity
I6I07_20560	COG1024	Enoyl-CoA hydratase
I6I07_20610	COG0583	DNA-binding transcription factor activity
I6I07_20635	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I07_20700	COG4774	siderophore transport
I6I07_20710	COG4774	siderophore transport
I6I07_20765	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_20770	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I07_20775	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_20780	COG0583	DNA-binding transcription factor activity
I6I07_20795	COG0747	negative chemotaxis
I6I07_20800	COG4608	Belongs to the ABC transporter superfamily
I6I07_20810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_20815	COG0601	transmembrane transport
I6I07_20820	COG2072	flavoprotein involved in K transport
I6I07_20840	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_20845	COG3048	D-serine ammonia-lyase activity
I6I07_20870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I07_20880	COG0583	DNA-binding transcription factor activity
I6I07_20910	COG0519	Catalyzes the synthesis of GMP from XMP
I6I07_20910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I07_20915	COG0582	viral genome integration into host DNA
I6I07_20940	COG2003	Belongs to the UPF0758 family
I6I07_20990	COG4959	Type IV secretory pathway protease TraF
I6I07_21005	COG0300	oxidoreductase activity
I6I07_21015	COG0583	DNA-binding transcription factor activity
I6I07_21035	COG4962	Type ii secretion system protein e
I6I07_21040	COG3838	Conjugal transfer protein Trbc
I6I07_21050	COG3451	type IV secretory pathway VirB4
I6I07_21065	COG3846	protein secretion by the type IV secretion system
I6I07_21100	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6I07_21115	COG0515	serine threonine protein kinase
I6I07_21115	COG2815	serine threonine protein kinase
I6I07_21130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I07_21170	COG3328	transposase activity
I6I07_21195	COG0640	Transcriptional regulator
I6I07_21200	COG0583	DNA-binding transcription factor activity
I6I07_21205	COG1335	isochorismatase
I6I07_21225	COG2207	Transcriptional regulator
I6I07_21230	COG4221	oxidoreductase activity
I6I07_21235	COG0300	oxidoreductase activity
I6I07_21250	COG2267	carboxylic ester hydrolase activity
I6I07_21255	COG2207	Transcriptional regulator
I6I07_21285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I07_21300	COG0583	DNA-binding transcription factor activity
I6I07_21315	COG0165	Argininosuccinate lyase
I6I07_21325	COG1214	PFAM Peptidase M22, glycoprotease
I6I07_21325	COG0456	acetyltransferase
I6I07_21345	COG2814	Major facilitator Superfamily
I6I07_21350	COG1864	DNA RNA non-specific endonuclease
I6I07_21350	COG3591	Belongs to the peptidase S1B family
I6I07_21360	COG0667	Aldo Keto reductase
I6I07_21365	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I07_21370	COG1129	ABC transporter
I6I07_21390	COG2188	Transcriptional regulator
I6I07_21425	COG0456	acetyltransferase
I6I07_21440	COG1199	ATP-dependent helicase activity
I6I07_21455	COG0583	DNA-binding transcription factor activity
I6I07_21470	COG0840	transmembrane signaling receptor activity
I6I07_21500	COG4251	negative regulation of phosphorylation
I6I07_21500	COG2203	Gaf domain
I6I07_21500	COG3706	GGDEF domain
I6I07_21500	COG5001	Diguanylate cyclase
I6I07_21505	COG4149	molybdate abc transporter
I6I07_21510	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I07_21515	COG3842	ATPase activity
I6I07_21520	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I07_21525	COG1522	sequence-specific DNA binding
I6I07_21535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I07_21545	COG2010	Cytochrome c
I6I07_21545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I07_21550	COG1335	isochorismatase
I6I07_21555	COG2309	aminopeptidase activity
I6I07_21560	COG0596	Alpha beta hydrolase
I6I07_21570	COG2080	2 iron, 2 sulfur cluster binding
I6I07_21575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I07_21575	COG2010	Cytochrome c
I6I07_21580	COG0477	Major facilitator Superfamily
I6I07_21585	COG1846	Transcriptional regulator
I6I07_21590	COG2814	Major facilitator Superfamily
I6I07_21595	COG4771	TonB-dependent receptor
I6I07_21610	COG0583	DNA-binding transcription factor activity
I6I07_21635	COG0583	DNA-binding transcription factor activity
I6I07_21640	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I07_21650	COG0318	PFAM AMP-dependent synthetase and ligase
I6I07_21655	COG1960	acyl-CoA dehydrogenase activity
I6I07_21660	COG1960	acyl-CoA dehydrogenase activity
I6I07_21665	COG0183	Belongs to the thiolase family
I6I07_21670	COG1024	Enoyl-CoA hydratase
I6I07_21670	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I07_21675	COG0583	DNA-binding transcription factor activity
I6I07_21705	COG2207	Transcriptional regulator
I6I07_21710	COG0148	phosphopyruvate hydratase activity
I6I07_21720	COG2733	membrane
I6I07_21730	COG0625	glutathione transferase activity
I6I07_21915	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I6I07_21925	COG2885	chlorophyll binding
I6I07_21955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I07_21975	COG3971	2-oxopent-4-enoate hydratase activity
I6I07_21980	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I07_22000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I07_22005	COG1414	Transcriptional regulator
I6I07_22015	COG3541	Predicted nucleotidyltransferase
I6I07_22020	COG1846	Transcriptional regulator
I6I07_22045	COG0456	acetyltransferase
I6I07_22055	COG0583	DNA-binding transcription factor activity
I6I07_22065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I07_22075	COG0697	spore germination
I6I07_22080	COG2207	Transcriptional regulator
I6I07_22085	COG4941	Belongs to the sigma-70 factor family
I6I07_22095	COG3795	YCII-related domain
I6I07_22100	COG3795	YCII-related domain
I6I07_22115	COG2885	chlorophyll binding
I6I07_22115	COG3047	cAMP biosynthetic process
I6I07_22135	COG2207	Transcriptional regulator
I6I07_22150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I07_22155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I07_22160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I07_22165	COG0084	hydrolase, TatD family'
I6I07_22180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_22185	COG0765	amino acid transport
I6I07_22190	COG1126	abc transporter atp-binding protein
I6I07_22195	COG0010	Belongs to the arginase family
I6I07_22205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I07_22215	COG4774	siderophore transport
I6I07_22225	COG0095	Lipoate-protein ligase
I6I07_22240	COG0625	glutathione transferase activity
I6I07_22250	COG1522	sequence-specific DNA binding
I6I07_22255	COG0386	Belongs to the glutathione peroxidase family
I6I07_22260	COG2814	Major facilitator Superfamily
I6I07_22285	COG3395	kinase activity
I6I07_22290	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I07_22300	COG0840	transmembrane signaling receptor activity
I6I07_22310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I07_22335	COG0513	Belongs to the DEAD box helicase family
I6I07_22340	COG1414	Transcriptional regulator
I6I07_22355	COG0747	negative chemotaxis
I6I07_22360	COG0601	transmembrane transport
I6I07_22370	COG4172	Belongs to the ABC transporter superfamily
I6I07_22375	COG1228	amidohydrolase
I6I07_22380	COG0523	cobalamin synthesis protein
I6I07_22390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I07_22410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I07_22415	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I07_22420	COG4521	taurine ABC transporter
I6I07_22440	COG1966	Carbon starvation protein
I6I07_22445	COG2879	small protein
I6I07_22450	COG0697	spore germination
I6I07_22455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I07_22475	COG0783	Belongs to the Dps family
I6I07_22490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I07_22495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I07_22505	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I07_22510	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6I07_22515	COG0745	RESPONSE REGULATOR receiver
I6I07_22520	COG5002	protein histidine kinase activity
I6I07_22525	COG2070	2-Nitropropane dioxygenase
I6I07_22545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I07_22580	COG4771	TonB-dependent receptor
I6I07_22610	COG0583	DNA-binding transcription factor activity
I6I07_22615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I07_22630	COG0038	chloride channel
I6I07_22640	COG0583	DNA-binding transcription factor activity
I6I07_22665	COG2223	nitrite transmembrane transporter activity
I6I07_22670	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6I07_22675	COG1140	nitrate reductase beta subunit
I6I07_22680	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6I07_22685	COG2181	nitrate reductase activity
I6I07_22690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I07_22695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I07_22700	COG0288	reversible hydration of carbon dioxide
I6I07_22705	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6I07_22710	COG3850	Histidine kinase
I6I07_22715	COG2197	response regulator
I6I07_22720	COG0826	peptidase U32
I6I07_22725	COG0826	peptidase U32
I6I07_22730	COG3154	lipid carrier protein
I6I07_22735	COG4597	amino acid ABC transporter
I6I07_22740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_22745	COG1104	cysteine desulfurase activity
I6I07_22775	COG1116	anion transmembrane transporter activity
I6I07_22780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I07_22785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I07_22810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I07_22830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I07_22835	COG1802	Transcriptional regulator
I6I07_22845	COG4948	Mandelate Racemase Muconate Lactonizing
I6I07_22870	COG2375	cellular response to nickel ion
I6I07_22870	COG1132	(ABC) transporter
I6I07_22880	COG4774	siderophore transport
I6I07_22885	COG1309	transcriptional regulator
I6I07_22905	COG0251	oxidation-reduction process
I6I07_22930	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6I07_22955	COG0277	FAD linked oxidase domain protein
I6I07_22960	COG0436	Aminotransferase
I6I07_22965	COG0765	amino acid transport
I6I07_22975	COG1126	abc transporter atp-binding protein
I6I07_22995	COG0583	DNA-binding transcription factor activity
I6I07_23065	COG4566	intracellular signal transduction
I6I07_23070	COG4191	Histidine kinase
I6I07_23080	COG1846	Transcriptional regulator
I6I07_23090	COG0583	DNA-binding transcription factor activity
I6I07_23095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I07_23125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I07_23135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I07_23140	COG2070	2-Nitropropane dioxygenase
I6I07_23145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_23150	COG0765	amino acid transport
I6I07_23155	COG1126	abc transporter atp-binding protein
I6I07_23160	COG1595	DNA-templated transcription, initiation
I6I07_23165	COG3712	iron ion homeostasis
I6I07_23170	COG4774	siderophore transport
I6I07_23200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I07_23220	COG0657	acetylesterase activity
I6I07_23225	COG4774	siderophore transport
I6I07_23255	COG1120	ATPase activity
I6I07_23260	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I07_23265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I07_23270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I07_23290	COG1136	(ABC) transporter
I6I07_23295	COG0390	transport system, permease component
I6I07_23300	COG0586	Pfam SNARE associated Golgi protein
I6I07_23320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I07_23325	COG1120	ATPase activity
I6I07_23330	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I6I07_23335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I07_23345	COG0745	RESPONSE REGULATOR receiver
I6I07_23350	COG0642	Histidine kinase
I6I07_23370	COG2721	sulfolactate sulfo-lyase activity
I6I07_23375	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_23405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I07_23405	COG0519	Catalyzes the synthesis of GMP from XMP
I6I07_23410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I07_23420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I07_23425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I07_23430	COG2358	TRAP transporter, solute receptor (TAXI family
I6I07_23440	COG4774	siderophore transport
I6I07_23450	COG1595	DNA-templated transcription, initiation
I6I07_23455	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I07_23460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I07_23465	COG4208	sulfate ABC transporter
I6I07_23470	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I07_23475	COG4150	thiosulfate binding
I6I07_23480	COG0583	DNA-binding transcription factor activity
I6I07_23485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I07_23490	COG0747	negative chemotaxis
I6I07_23495	COG0601	transmembrane transport
I6I07_23500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_23505	COG0444	Belongs to the ABC transporter superfamily
I6I07_23525	COG0583	DNA-binding transcription factor activity
I6I07_23530	COG0626	cystathionine gamma-synthase activity
I6I07_23535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_23540	COG4597	amino acid ABC transporter
I6I07_23545	COG0765	amino acid transport
I6I07_23550	COG1126	abc transporter atp-binding protein
I6I07_23555	COG1595	DNA-templated transcription, initiation
I6I07_23560	COG4774	siderophore transport
I6I07_23565	COG3712	iron ion homeostasis
I6I07_23585	COG0583	DNA-binding transcription factor activity
I6I07_23590	COG2957	Belongs to the agmatine deiminase family
I6I07_23600	COG1045	serine acetyltransferase
I6I07_23605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I07_23610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I07_23615	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6I07_23625	COG1121	(ABC) transporter
I6I07_23630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I07_23635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I07_23645	COG2207	Transcriptional regulator
I6I07_23655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I07_23665	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I07_23690	COG0583	DNA-binding transcription factor activity
I6I07_23725	COG1609	Transcriptional regulator
I6I07_23740	COG1175	transmembrane transport
I6I07_23765	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_23770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I07_23785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I07_23790	COG0583	DNA-binding transcription factor activity
I6I07_23825	COG0579	oxidoreductase
I6I07_23850	COG0625	glutathione transferase activity
I6I07_23875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_23895	COG3971	2-oxopent-4-enoate hydratase activity
I6I07_23920	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6I07_23935	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I07_23955	COG0251	oxidation-reduction process
I6I07_23965	COG0747	negative chemotaxis
I6I07_23970	COG0601	transmembrane transport
I6I07_23980	COG0444	Belongs to the ABC transporter superfamily
I6I07_23985	COG4608	Belongs to the ABC transporter superfamily
I6I07_23990	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I07_24000	COG0531	amino acid
I6I07_24005	COG2226	methyltransferase
I6I07_24030	COG0628	permease
I6I07_24040	COG4774	siderophore transport
I6I07_24050	COG4139	cobalamin transport
I6I07_24055	COG1120	ATPase activity
I6I07_24075	COG0583	DNA-binding transcription factor activity
I6I07_24080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I07_24090	COG3706	GGDEF domain
I6I07_24100	COG0789	Transcriptional regulator
I6I07_24105	COG3706	GGDEF domain
I6I07_24255	COG0667	Aldo Keto reductase
I6I07_24260	COG0583	DNA-binding transcription factor activity
I6I07_24265	COG1024	Enoyl-CoA hydratase
I6I07_24275	COG2205	protein histidine kinase activity
I6I07_24280	COG1253	flavin adenine dinucleotide binding
I6I07_24330	COG5001	Diguanylate cyclase
I6I07_24330	COG3300	MHYT domain
I6I07_24335	COG1289	transmembrane transporter activity
I6I07_24345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I07_24365	COG0693	protein deglycase activity
I6I07_24385	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_24415	COG2204	response regulator
I6I07_24420	COG2204	response regulator
I6I07_24425	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I07_24445	COG4771	TonB-dependent receptor
I6I07_24475	COG2814	Major facilitator Superfamily
I6I07_24495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I07_24500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I07_24525	COG0488	(ABC) transporter
I6I07_24535	COG0688	phosphatidylethanolamine metabolic process
I6I07_24565	COG1408	metallophosphoesterase
I6I07_24575	COG2814	Major facilitator Superfamily
I6I07_24585	COG1464	Belongs to the NlpA lipoprotein family
I6I07_24590	COG0010	Belongs to the arginase family
I6I07_24600	COG2363	Small membrane protein
I6I07_24605	COG0697	spore germination
I6I07_24615	COG2133	pyrroloquinoline quinone binding
I6I07_24620	COG0625	glutathione transferase activity
I6I07_24625	COG0583	DNA-binding transcription factor activity
I6I07_24635	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I07_24640	COG1794	racemase activity, acting on amino acids and derivatives
I6I07_24660	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I07_24675	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I07_24685	COG1653	transport
I6I07_24690	COG1175	transmembrane transport
I6I07_24695	COG0395	ABC-type sugar transport system, permease component
I6I07_24700	COG3842	ATPase activity
I6I07_24715	COG2205	protein histidine kinase activity
I6I07_24720	COG0745	RESPONSE REGULATOR receiver
I6I07_24735	COG3866	Pectate lyase
I6I07_24740	COG1560	Kdo2-lipid A biosynthetic process
I6I07_24740	COG4783	chaperone-mediated protein folding
I6I07_24765	COG0438	transferase activity, transferring glycosyl groups
I6I07_24770	COG0457	Tetratricopeptide repeat
I6I07_24780	COG0783	Belongs to the Dps family
I6I07_24790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I07_24810	COG0583	DNA-binding transcription factor activity
I6I07_24835	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I07_24840	COG4149	molybdate abc transporter
I6I07_24845	COG3842	ATPase activity
I6I07_24850	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_24855	COG1741	Belongs to the pirin family
I6I07_24860	COG1741	Belongs to the pirin family
I6I07_24865	COG0583	DNA-binding transcription factor activity
I6I07_24870	COG2204	response regulator
I6I07_24880	COG0174	glutamine synthetase
I6I07_24885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I07_24890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I07_24905	COG1960	acyl-CoA dehydrogenase activity
I6I07_24915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I07_24920	COG1561	YicC-like family, N-terminal region
I6I07_24925	COG0833	amino acid
I6I07_24930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I07_24945	COG0791	NLP P60 protein
I6I07_24950	COG3210	domain, Protein
I6I07_24955	COG2831	hemolysin activation secretion protein
I6I07_24960	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_24965	COG2863	cytochrome
I6I07_24970	COG3258	Cytochrome c
I6I07_24975	COG0194	GDP metabolic process
I6I07_24980	COG1758	RNA polymerase activity
I6I07_24985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I07_24990	COG1126	abc transporter atp-binding protein
I6I07_24995	COG0765	amino acid transport
I6I07_25000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_25025	COG2816	NAD+ diphosphatase activity
I6I07_25045	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I07_25075	COG4336	lyase activity
I6I07_25080	COG0583	DNA-binding transcription factor activity
I6I07_25095	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I07_25110	COG0583	DNA-binding transcription factor activity
I6I07_25120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I07_25125	COG0560	Phosphoserine phosphatase
I6I07_25130	COG0583	DNA-binding transcription factor activity
I6I07_25135	COG3842	ATPase activity
I6I07_25140	COG1178	ABC-type Fe3 transport system permease component
I6I07_25150	COG4181	ATPase activity
I6I07_25160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I07_25170	COG0584	glycerophosphoryl diester phosphodiesterase
I6I07_25175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I07_25190	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I6I07_25200	COG2986	histidine ammonia-lyase
I6I07_25210	COG0678	peroxiredoxin activity
I6I07_25210	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I07_25225	COG0789	Transcriptional regulator
I6I07_25230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I07_25265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I07_25270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I07_25275	COG2252	PERMEase
I6I07_25285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I07_25290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I07_25325	COG0488	(ABC) transporter
I6I07_25345	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6I07_25350	COG0590	tRNA wobble adenosine to inosine editing
I6I07_25365	COG1320	monovalent cation:proton antiporter activity
I6I07_25370	COG2212	antiporter activity
I6I07_25375	COG1863	multisubunit Na H antiporter MnhE subunit
I6I07_25380	COG0651	ATP synthesis coupled electron transport
I6I07_25385	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I07_25390	COG2111	Na H antiporter
I6I07_25390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I07_25400	COG4774	siderophore transport
I6I07_25425	COG0420	3'-5' exonuclease activity
I6I07_25430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I07_25470	COG4774	siderophore transport
I6I07_25480	COG1960	acyl-CoA dehydrogenase activity
I6I07_25485	COG1959	2 iron, 2 sulfur cluster binding
I6I07_25490	COG3634	alkyl hydroperoxide reductase activity
I6I07_25515	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I07_25520	COG0346	lactoylglutathione lyase activity
I6I07_25565	COG0395	ABC-type sugar transport system, permease component
I6I07_25575	COG3842	ATPase activity
I6I07_25580	COG3842	ATPase activity
I6I07_25605	COG2130	NADP-dependent
I6I07_25610	COG1309	transcriptional regulator
I6I07_25620	COG1131	(ABC) transporter
I6I07_25625	COG0842	Transport permease protein
I6I07_25640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I07_25670	COG1902	pentaerythritol trinitrate reductase activity
I6I07_25685	COG0602	queuosine metabolic process
I6I07_25690	COG0720	synthase
I6I07_25700	COG1289	transmembrane transporter activity
I6I07_25710	COG1566	PFAM secretion protein HlyD family protein
I6I07_25725	COG0028	Belongs to the TPP enzyme family
I6I07_25735	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_25745	COG0400	carboxylic ester hydrolase activity
I6I07_25750	COG0833	amino acid
I6I07_25765	COG0587	DNA-directed DNA polymerase activity
I6I07_25785	COG0667	Aldo Keto reductase
I6I07_25795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I07_25830	COG0765	amino acid transport
I6I07_25835	COG0765	amino acid transport
I6I07_25840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_25845	COG0436	Aminotransferase
I6I07_25850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I07_25875	COG3038	cytochrome b561
I6I07_25905	COG0840	transmembrane signaling receptor activity
I6I07_25995	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6I07_26015	COG4771	TonB-dependent receptor
I6I07_26020	COG2345	Transcriptional regulator
I6I07_26030	COG1414	Transcriptional regulator
I6I07_26040	COG0477	Major facilitator Superfamily
I6I07_26050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I07_26055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I07_26065	COG0667	Aldo Keto reductase
I6I07_26075	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_26080	COG1309	transcriptional regulator
I6I07_26100	COG1683	Conserved Protein
I6I07_26120	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I07_26120	COG1024	Enoyl-CoA hydratase
I6I07_26135	COG2867	negative regulation of translational initiation
I6I07_26140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I07_26160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I07_26160	COG0519	Catalyzes the synthesis of GMP from XMP
I6I07_26165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I07_26165	COG2169	Transcriptional regulator
I6I07_26180	COG4774	siderophore transport
I6I07_26205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I07_26210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I07_26225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I07_26230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I07_26235	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6I07_26240	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I07_26245	COG0750	zinc metalloprotease
I6I07_26250	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I07_26260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I07_26265	COG0233	cytoplasmic translational termination
I6I07_26270	COG0528	UMP kinase activity
I6I07_26275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I07_26280	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I07_26290	COG0024	Methionine aminopeptidase
I6I07_26295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I07_26305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I07_26310	COG1451	nucleotide metabolic process
I6I07_26330	COG0285	dihydrofolate synthase activity
I6I07_26340	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_26345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I07_26365	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6I07_26385	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I07_26395	COG1677	Flagellar hook-basal body complex protein FliE
I6I07_26405	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I07_26430	COG1580	Controls the rotational direction of flagella during chemotaxis
I6I07_26440	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I07_26465	COG0840	transmembrane signaling receptor activity
I6I07_26470	COG0840	transmembrane signaling receptor activity
I6I07_26480	COG0840	transmembrane signaling receptor activity
I6I07_26485	COG0840	transmembrane signaling receptor activity
I6I07_26520	COG4787	bacterial-type flagellum-dependent cell motility
I6I07_26535	COG1558	bacterial-type flagellum-dependent cell motility
I6I07_26540	COG1815	bacterial-type flagellum-dependent cell motility
I6I07_26550	COG2747	anti-sigma28 factor FlgM
I6I07_26565	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I07_26575	COG0840	transmembrane signaling receptor activity
I6I07_26580	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6I07_26585	COG0745	RESPONSE REGULATOR receiver
I6I07_26590	COG2201	protein-glutamate methylesterase activity
I6I07_26595	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I07_26600	COG0840	transmembrane signaling receptor activity
I6I07_26605	COG0835	chemotaxis
I6I07_26615	COG0745	RESPONSE REGULATOR receiver
I6I07_26640	COG1191	sigma factor activity
I6I07_26645	COG4797	methyltransferase
I6I07_26645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I07_26660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I07_26670	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I6I07_26680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I07_26690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I07_26720	COG0583	DNA-binding transcription factor activity
I6I07_26730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I07_26735	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I07_26740	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I07_26750	COG4566	intracellular signal transduction
I6I07_26755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I07_26760	COG0339	signal peptide processing
I6I07_26770	COG1999	signal sequence binding
I6I07_26795	COG0583	DNA-binding transcription factor activity
I6I07_26800	COG1187	pseudouridine synthase activity
I6I07_26805	COG3161	chorismate lyase activity
I6I07_26810	COG0477	Major facilitator Superfamily
I6I07_26825	COG4681	YaeQ
I6I07_26830	COG4172	Belongs to the ABC transporter superfamily
I6I07_26835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_26840	COG0601	transmembrane transport
I6I07_26845	COG0747	negative chemotaxis
I6I07_26855	COG0583	DNA-binding transcription factor activity
I6I07_26890	COG2165	general secretion pathway protein
I6I07_26960	COG0668	transmembrane transport
I6I07_26965	COG0165	Argininosuccinate lyase
I6I07_26985	COG0022	dehydrogenase e1 component
I6I07_26995	COG4774	siderophore transport
I6I07_27020	COG0789	Transcriptional regulator
I6I07_27040	COG2271	Major facilitator Superfamily
I6I07_27050	COG0307	riboflavin synthase, alpha
I6I07_27115	COG0154	amidase activity
I6I07_27120	COG2814	Major facilitator Superfamily
I6I07_27130	COG2226	methyltransferase
I6I07_27135	COG4608	Belongs to the ABC transporter superfamily
I6I07_27140	COG0444	Belongs to the ABC transporter superfamily
I6I07_27150	COG0601	transmembrane transport
I6I07_27155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I07_27180	COG0747	negative chemotaxis
I6I07_27195	COG2814	Major facilitator Superfamily
I6I07_27200	COG0583	DNA-binding transcription factor activity
I6I07_27210	COG0583	DNA-binding transcription factor activity
I6I07_27225	COG1733	regulation of RNA biosynthetic process
I6I07_27235	COG0583	DNA-binding transcription factor activity
I6I07_27310	COG0318	PFAM AMP-dependent synthetase and ligase
I6I07_27325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I07_27335	COG5265	(ABC) transporter
I6I07_27340	COG1280	lysine exporter protein (LysE YggA)
I6I07_27380	COG0318	PFAM AMP-dependent synthetase and ligase
I6I07_27385	COG2188	Transcriptional regulator
I6I07_27400	COG0477	Major facilitator Superfamily
I6I07_27405	COG0235	Class ii aldolase
I6I07_27445	COG2610	gluconate transmembrane transporter activity
I6I07_27450	COG0583	DNA-binding transcription factor activity
I6I07_27455	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_27465	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6I07_27510	COG1024	Enoyl-CoA hydratase
I6I07_27515	COG5001	Diguanylate cyclase
I6I07_27520	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_27525	COG0129	dihydroxy-acid dehydratase activity
I6I07_27535	COG0583	DNA-binding transcription factor activity
I6I07_27540	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I07_27545	COG3246	L-lysine catabolic process to acetate
I6I07_27565	COG0243	molybdopterin cofactor binding
I6I07_27570	COG3043	anaerobic respiration
I6I07_27575	COG3005	denitrification pathway
I6I07_27580	COG4133	protoheme IX ABC transporter activity
I6I07_27600	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I07_27610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I07_27640	COG3381	protein complex oligomerization
I6I07_27660	COG4133	protoheme IX ABC transporter activity
I6I07_27670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I07_27680	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I07_27690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I07_27695	COG3088	subunit of a heme lyase
I6I07_27715	COG0109	protoheme IX farnesyltransferase activity
I6I07_27720	COG0583	DNA-binding transcription factor activity
I6I07_27735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I07_27740	COG4977	sequence-specific DNA binding
I6I07_27745	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_27755	COG1595	DNA-templated transcription, initiation
I6I07_27760	COG3712	iron ion homeostasis
I6I07_27790	COG2207	Transcriptional regulator
I6I07_27825	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_27835	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I07_27840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I07_27850	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_27855	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I07_27860	COG0534	Mate efflux family protein
I6I07_27875	COG0697	spore germination
I6I07_27880	COG0697	spore germination
I6I07_27895	COG1280	lysine exporter protein (LysE YggA)
I6I07_27915	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I07_27920	COG3245	cytochrome
I6I07_27930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I07_27945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I07_27970	COG0318	PFAM AMP-dependent synthetase and ligase
I6I07_27975	COG1960	acyl-CoA dehydrogenase activity
I6I07_27990	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I07_28000	COG2814	Major facilitator Superfamily
I6I07_28015	COG0625	glutathione transferase activity
I6I07_28020	COG0583	DNA-binding transcription factor activity
I6I07_28025	COG0583	DNA-binding transcription factor activity
I6I07_28030	COG2814	Major facilitator Superfamily
I6I07_28035	COG0583	DNA-binding transcription factor activity
I6I07_28055	COG0506	proline dehydrogenase activity
I6I07_28060	COG0697	spore germination
I6I07_28065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I07_28070	COG1959	2 iron, 2 sulfur cluster binding
I6I07_28080	COG1610	YqeY-like protein
I6I07_28115	COG0457	Tetratricopeptide repeat
I6I07_28120	COG0726	polysaccharide deacetylase
I6I07_28120	COG1649	PFAM Uncharacterised BCR, COG1649
I6I07_28125	COG1215	transferase activity, transferring glycosyl groups
I6I07_28135	COG2223	nitrite transmembrane transporter activity
I6I07_28150	COG1595	DNA-templated transcription, initiation
I6I07_28155	COG3712	iron ion homeostasis
I6I07_28160	COG4774	siderophore transport
I6I07_28165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I07_28180	COG0656	L-ascorbic acid biosynthetic process
I6I07_28185	COG5265	(ABC) transporter
I6I07_28215	COG1116	anion transmembrane transporter activity
I6I07_28240	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_28245	COG0583	DNA-binding transcription factor activity
I6I07_28275	COG1522	sequence-specific DNA binding
I6I07_28300	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_28320	COG0456	acetyltransferase
I6I07_28325	COG0384	phenazine biosynthesis protein PhzF
I6I07_28380	COG0072	phenylalanine-tRNA ligase activity
I6I07_28380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I07_28385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I07_28390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I07_28395	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I07_28405	COG2960	long-chain fatty acid transporting porin activity
I6I07_28415	COG0347	Belongs to the P(II) protein family
I6I07_28420	COG0004	ammonium transporteR
I6I07_28425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I07_28430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I07_28445	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I07_28450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I07_28460	COG2197	response regulator
I6I07_28465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I07_28470	COG0789	Transcriptional regulator
I6I07_28500	COG1012	belongs to the aldehyde dehydrogenase family
I6I07_28510	COG0601	transmembrane transport
I6I07_28515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I07_28540	COG1609	Transcriptional regulator
I6I07_28545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I07_28550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I07_28555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I07_28560	COG0129	dihydroxy-acid dehydratase activity
I6I07_28565	COG2755	lipolytic protein G-D-S-L family
I6I07_28565	COG0657	acetylesterase activity
I6I07_28600	COG0135	phosphoribosylanthranilate isomerase activity
I6I07_28605	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6I07_28610	COG0101	tRNA pseudouridine synthase activity
I6I07_28620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I07_28640	COG4783	chaperone-mediated protein folding
I6I07_28645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I07_28655	COG3706	GGDEF domain
I6I07_28660	COG5002	protein histidine kinase activity
I6I07_28670	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I07_28680	COG1295	ribonuclease BN
I6I07_28690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I07_28720	COG4964	Belongs to the GSP D family
I6I07_28750	COG2755	lipolytic protein G-D-S-L family
I6I07_28750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I07_28785	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I07_28790	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6I07_28795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I07_28800	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6I07_28805	COG0330	HflC and HflK could
I6I07_28810	COG0330	HflC and HflK could
I6I07_28815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I07_28820	COG1923	regulation of RNA biosynthetic process
I6I07_28825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I07_28830	COG1160	GTP binding
I6I07_28835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I07_28840	COG2976	Protein conserved in bacteria
I6I07_28860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I07_28865	COG0105	UTP biosynthetic process
I6I07_28870	COG0525	valine-tRNA ligase activity
I6I07_28875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I07_28880	COG1126	abc transporter atp-binding protein
I6I07_28885	COG0765	amino acid transport
I6I07_28890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I07_28895	COG1396	sequence-specific DNA binding
I6I07_28900	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I07_28910	COG0228	four-way junction DNA binding
I6I07_28920	COG0425	Belongs to the sulfur carrier protein TusA family
I6I07_28925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I07_28940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I07_28955	COG2076	Multidrug Resistance protein
I6I07_28960	COG3217	Mosc domain protein beta barrel domain protein
I6I07_28960	COG0633	Ferredoxin
I6I07_28965	COG5285	phytanoyl-CoA dioxygenase
I6I07_28970	COG0662	Cupin 2, conserved barrel domain protein
I6I07_28995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I07_29000	COG2311	Membrane
I6I07_29005	COG1309	transcriptional regulator
I6I07_29030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I07_29045	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I07_29050	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I07_29070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I07_29080	COG3391	amine dehydrogenase activity
I6I07_29110	COG1846	Transcriptional regulator
I6I07_29120	COG1566	PFAM secretion protein HlyD family protein
I6I07_29125	COG2814	Major facilitator Superfamily
I6I07_29135	COG0473	3-isopropylmalate dehydrogenase activity
I6I07_29140	COG0433	COG0433 Predicted ATPase
I6I07_29145	COG0217	transcriptional regulatory protein
I6I07_29150	COG0151	Belongs to the GarS family
I6I07_29160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I07_29165	COG0799	negative regulation of ribosome biogenesis
I6I07_29170	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6I07_29180	COG1301	dicarboxylic acid transport
I6I07_29185	COG4191	Histidine kinase
I6I07_29190	COG2204	response regulator
I6I07_29220	COG1530	ribonuclease E activity
I6I07_29245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I07_29245	COG0475	glutathione-regulated potassium exporter activity
I6I07_29250	COG1132	(ABC) transporter
I6I07_29275	COG0726	polysaccharide deacetylase
I6I07_29290	COG0726	polysaccharide deacetylase
I6I07_29295	COG0438	transferase activity, transferring glycosyl groups
I6I07_29310	COG1116	anion transmembrane transporter activity
I6I07_29315	COG0395	ABC-type sugar transport system, permease component
I6I07_29320	COG1643	Atp-dependent helicase
I6I07_29325	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I07_29325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I07_29330	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6I07_29340	COG0704	Plays a role in the regulation of phosphate uptake
I6I07_29350	COG1960	acyl-CoA dehydrogenase activity
I6I07_29380	COG1177	transmembrane transport
I6I07_29385	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I07_29390	COG3842	ATPase activity
I6I07_29400	COG3642	lipopolysaccharide core region biosynthetic process
I6I07_29410	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I07_29415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I07_29425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I07_29425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I07_29435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I07_29440	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I07_29445	COG2945	thiolester hydrolase activity
I6I07_29445	COG0596	Alpha beta hydrolase
I6I07_29465	COG3618	amidohydrolase
I6I07_29470	COG0583	DNA-binding transcription factor activity
I6I07_29475	COG5002	protein histidine kinase activity
I6I07_29485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I07_29495	COG1538	Outer membrane efflux protein
I6I07_29500	COG0137	argininosuccinate synthase activity
I6I07_29505	COG3158	transport of potassium into the cell
I6I07_29510	COG0642	Histidine kinase
I6I07_29545	COG0776	regulation of translation
I6I07_29550	COG3128	pkhd-type hydroxylase
I6I07_29560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I07_29565	COG0557	exoribonuclease II activity
I6I07_29595	COG0679	Auxin Efflux Carrier
I6I07_29600	COG2391	methyltransferase activity
I6I07_29605	COG0069	glutamate synthase activity
I6I07_29610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I07_29620	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6I07_29660	COG0697	spore germination
I6I07_29780	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6I07_29790	COG0628	permease
I6I07_29820	COG3909	cytochrome
I6I07_29830	COG0625	glutathione transferase activity
I6I07_29835	COG0730	response to heat
I6I07_29840	COG0482	sulfurtransferase activity
I6I07_29845	COG0583	DNA-binding transcription factor activity
I6I07_29875	COG0247	lactate metabolic process
I6I07_29880	COG0277	FAD linked oxidase domain protein
I6I07_29885	COG0277	FAD linked oxidase domain protein
I6I07_29890	COG0277	FAD linked oxidase domain protein
I6I07_29895	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I07_29905	COG0312	modulator of DNA gyrase
I6I07_29920	COG0308	aminopeptidase N
I6I07_29925	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6I07_29945	COG0436	Aminotransferase
I6I07_29955	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I07_29960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6I07_29980	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I07_29995	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_30010	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_30040	COG0181	hydroxymethylbilane synthase activity
I6I07_30045	COG0861	Integral membrane protein TerC family
I6I07_30050	COG0861	Integral membrane protein TerC family
I6I07_30055	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I07_30060	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I07_30085	COG2137	regulation of response to DNA damage stimulus
I6I07_30090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I07_30125	COG0540	Belongs to the ATCase OTCase family
I6I07_30180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I07_30215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I07_30225	COG0305	Participates in initiation and elongation during chromosome replication
I6I07_30235	COG0359	binds to the 23S rRNA
I6I07_30240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I07_30245	COG2965	DNA replication, synthesis of RNA primer
I6I07_30250	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I07_30255	COG3739	integral membrane protein
I6I07_30260	COG1469	GTP cyclohydrolase I activity
I6I07_30270	COG0142	geranyltranstransferase activity
I6I07_30275	COG1722	exodeoxyribonuclease VII activity
I6I07_30285	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_30305	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I07_30310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I07_30320	COG3842	ATPase activity
I6I07_30345	COG0501	Belongs to the peptidase M48B family
I6I07_30350	COG1760	l-serine dehydratase
I6I07_30355	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I07_30360	COG0412	Dienelactone hydrolase
I6I07_30375	COG1611	Belongs to the LOG family
I6I07_30380	COG1473	amidohydrolase
I6I07_30385	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_30405	COG1217	gtp-binding protein TYPA
I6I07_30410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I07_30415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I07_30420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I07_30425	COG2251	uridine kinase activity
I6I07_30425	COG0195	Participates in both transcription termination and antitermination
I6I07_30430	COG0779	Required for maturation of 30S ribosomal subunits
I6I07_30435	COG1187	pseudouridine synthase activity
I6I07_30440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I07_30450	COG0583	DNA-binding transcription factor activity
I6I07_30455	COG0523	cobalamin synthesis protein
I6I07_30460	COG0523	cobalamin synthesis protein
I6I07_30485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I07_30490	COG0625	glutathione transferase activity
I6I07_30495	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I07_30505	COG2003	Belongs to the UPF0758 family
I6I07_30510	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6I07_30515	COG3483	tryptophan 2,3-dioxygenase activity
I6I07_30530	COG0534	Mate efflux family protein
I6I07_30540	COG2050	protein possibly involved in aromatic compounds catabolism
I6I07_30545	COG1024	Enoyl-CoA hydratase
I6I07_30550	COG1012	belongs to the aldehyde dehydrogenase family
I6I07_30555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I07_30560	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I07_30565	COG3396	Phenylacetate-CoA oxygenase
I6I07_30570	COG3460	Phenylacetate-CoA oxygenase
I6I07_30575	COG3396	Phenylacetate-CoA oxygenase
I6I07_30580	COG3327	negative regulation of DNA-templated transcription, initiation
I6I07_30585	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I07_30590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I07_30595	COG0501	Belongs to the peptidase M48B family
I6I07_30600	COG1162	GTPase activity
I6I07_30605	COG0494	nUDIX hydrolase
I6I07_30610	COG0335	large ribosomal subunit rRNA binding
I6I07_30630	COG2895	sulfate adenylyltransferase (ATP) activity
I6I07_30640	COG0175	sulfate reduction
I6I07_30650	COG4208	sulfate ABC transporter
I6I07_30655	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I07_30665	COG0450	alkyl hydroperoxide reductase
I6I07_30670	COG1960	acyl-CoA dehydrogenase activity
I6I07_30675	COG2985	domain, Protein
I6I07_30700	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6I07_30705	COG2951	lytic endotransglycosylase activity
I6I07_30735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I07_30740	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I07_30745	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6I07_30765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I07_30770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I07_30780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I07_30790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I07_30805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I07_30815	COG2814	Major facilitator Superfamily
I6I07_30835	COG2951	lytic endotransglycosylase activity
I6I07_30855	COG1132	(ABC) transporter
I6I07_30860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I07_30860	COG0189	ligase activity
I6I07_30865	COG0189	ligase activity
I6I07_30865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I07_30870	COG3237	CsbD-like
I6I07_30880	COG2823	Periplasmic or secreted lipoprotein
I6I07_30910	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
I6I07_30915	COG1028	Short-chain dehydrogenase reductase Sdr
I6I07_30920	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6I07_30925	COG1496	oxidoreductase activity
I6I07_30930	COG0564	pseudouridine synthase activity
I6I07_30940	COG1199	ATP-dependent helicase activity
I6I07_30945	COG2183	response to ionizing radiation
I6I07_30980	COG4774	siderophore transport
I6I07_30985	COG3712	iron ion homeostasis
I6I07_30990	COG1595	DNA-templated transcription, initiation
I6I07_30995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I07_31000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I07_31005	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I07_31010	COG0567	Dehydrogenase, E1 component
I6I07_31015	COG1522	sequence-specific DNA binding
I6I07_31035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I07_31040	COG1297	OPT oligopeptide transporter protein
I6I07_31050	COG0281	malic enzyme
I6I07_31050	COG0280	phosphate acetyltransferase
I6I07_31065	COG0372	Belongs to the citrate synthase family
I6I07_31070	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6I07_31075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I07_31080	COG1053	succinate dehydrogenase
I6I07_31085	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I07_31090	COG2009	succinate dehydrogenase
I6I07_31095	COG2188	Transcriptional regulator
I6I07_31100	COG0039	L-malate dehydrogenase activity
I6I07_31120	COG1981	membrane
I6I07_31155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I07_31165	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I07_31180	COG0148	phosphopyruvate hydratase activity
I6I07_31190	COG0504	CTP synthase activity
I6I07_31225	COG0747	negative chemotaxis
I6I07_31230	COG4172	Belongs to the ABC transporter superfamily
I6I07_31235	COG1446	asparaginase
I6I07_31245	COG2153	protein acetylation
I6I07_31270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I07_31290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I07_31295	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6I07_31300	COG0697	spore germination
I6I07_31305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I07_31315	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6I07_31325	COG0791	NLP P60 protein
I6I07_31335	COG0583	DNA-binding transcription factor activity
I6I07_31360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I07_31390	COG3181	Tripartite tricarboxylate transporter family receptor
I6I07_31400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I07_31410	COG1381	Involved in DNA repair and RecF pathway recombination
I6I07_31415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I07_31420	COG0571	ribonuclease III activity
I6I07_31425	COG0681	Belongs to the peptidase S26 family
I6I07_31435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I07_31460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I07_31465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I07_31475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I07_31480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I07_31490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I07_31495	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I07_31500	COG0424	maF-like protein
I6I07_31510	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I07_31515	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6I07_31520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I07_31525	COG0546	phosphoglycolate phosphatase activity
I6I07_31530	COG0564	pseudouridine synthase activity
I6I07_31535	COG1530	ribonuclease E activity
I6I07_31540	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6I07_31545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I07_31550	COG0159	tryptophan synthase activity
I6I07_31560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I07_31570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I07_31575	COG3228	Belongs to the MtfA family
I6I07_31585	COG0251	oxidation-reduction process
I6I07_31590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I07_31610	COG2878	Part of a membrane complex involved in electron transport
I6I07_31615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate