locus-tag	class	description
APT56_00005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APT56_00010	COG0085	RNA polymerase activity
APT56_00015	COG0222	ribosome binding
APT56_00020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APT56_00025	COG0081	regulation of translation
APT56_00030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APT56_00040	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APT56_00050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APT56_00090	COG1840	ABC-type Fe3 transport system, periplasmic component
APT56_00095	COG3842	ATPase activity
APT56_00105	COG1349	DNA-binding transcription factor activity
APT56_00130	COG0583	DNA-binding transcription factor activity
APT56_00135	COG0252	asparaginase activity
APT56_00140	COG1475	DNA binding
APT56_00150	COG1192	Involved in chromosome partitioning
APT56_00155	COG0357	Ribosomal RNA small subunit methyltransferase G
APT56_00160	COG0445	tRNA wobble uridine modification
APT56_00165	COG1278	Cold shock
APT56_00170	COG3180	Ammonia monooxygenase
APT56_00175	COG0436	Aminotransferase
APT56_00195	COG2205	protein histidine kinase activity
APT56_00205	COG0038	chloride channel
APT56_00215	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APT56_00225	COG0601	transmembrane transport
APT56_00230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_00235	COG0444	Belongs to the ABC transporter superfamily
APT56_00240	COG4608	Belongs to the ABC transporter superfamily
APT56_00245	COG1473	amidohydrolase
APT56_00265	COG0753	catalase activity
APT56_00275	COG0594	ribonuclease P activity
APT56_00280	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APT56_00285	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APT56_00290	COG0592	DNA-directed DNA polymerase activity
APT56_00300	COG0583	DNA-binding transcription factor activity
APT56_00325	COG1574	metal-dependent hydrolase with the TIM-barrel fold
APT56_00335	COG0583	DNA-binding transcription factor activity
APT56_00340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_00345	COG0765	amino acid transport
APT56_00350	COG0765	amino acid transport
APT56_00355	COG1126	abc transporter atp-binding protein
APT56_00370	COG1254	Belongs to the acylphosphatase family
APT56_00380	COG1304	FMN binding
APT56_00390	COG3842	ATPase activity
APT56_00395	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT56_00400	COG1177	transmembrane transport
APT56_00415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_00455	COG1609	Transcriptional regulator
APT56_00465	COG3842	ATPase activity
APT56_00470	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT56_00475	COG1177	transmembrane transport
APT56_00500	COG0251	oxidation-reduction process
APT56_00510	COG3210	domain, Protein
APT56_00530	COG0402	S-adenosylhomocysteine deaminase activity
APT56_00550	COG1744	ABC transporter substrate-binding protein PnrA-like
APT56_00560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APT56_00575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT56_00590	COG2814	Major facilitator Superfamily
APT56_00595	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APT56_00605	COG3781	membrane
APT56_00610	COG1522	sequence-specific DNA binding
APT56_00615	COG0028	Belongs to the TPP enzyme family
APT56_00620	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_00625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_00630	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APT56_00650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT56_00655	COG2922	Belongs to the Smg family
APT56_00680	COG0765	amino acid transport
APT56_00685	COG0765	amino acid transport
APT56_00690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_00695	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_00700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APT56_00730	COG4977	sequence-specific DNA binding
APT56_00750	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
APT56_00765	COG3339	Conserved Protein
APT56_00775	COG1280	lysine exporter protein (LysE YggA)
APT56_00795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_00820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APT56_00825	COG0183	Belongs to the thiolase family
APT56_00830	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
APT56_00835	COG1960	acyl-CoA dehydrogenase activity
APT56_00840	COG1473	amidohydrolase
APT56_00855	COG1742	UPF0060 membrane protein
APT56_00870	COG1280	lysine exporter protein (LysE YggA)
APT56_00895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APT56_00905	COG0018	arginyl-trna synthetase
APT56_00920	COG0395	ABC-type sugar transport system, permease component
APT56_00925	COG1175	transmembrane transport
APT56_00930	COG1653	transport
APT56_00935	COG3842	ATPase activity
APT56_00940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APT56_00945	COG1609	Transcriptional regulator
APT56_00955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT56_00970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
APT56_00980	COG0583	DNA-binding transcription factor activity
APT56_01000	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APT56_01005	COG1280	lysine exporter protein (LysE YggA)
APT56_01010	COG0513	Belongs to the DEAD box helicase family
APT56_01015	COG5339	Protein conserved in bacteria
APT56_01020	COG5339	Protein conserved in bacteria
APT56_01025	COG1228	amidohydrolase
APT56_01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_01045	COG0747	negative chemotaxis
APT56_01060	COG3708	Transcriptional regulator
APT56_01060	COG2207	Transcriptional regulator
APT56_01070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APT56_01080	COG0583	DNA-binding transcription factor activity
APT56_01125	COG2969	positive regulation of protein catabolic process
APT56_01130	COG0625	glutathione transferase activity
APT56_01135	COG2857	Cytochrome c1
APT56_01140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APT56_01145	COG0723	plastoquinol--plastocyanin reductase activity
APT56_01150	COG1970	mechanosensitive ion channel activity
APT56_01155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APT56_01170	COG0805	protein transport
APT56_01175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APT56_01180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APT56_01185	COG0537	adenosine 5'-monophosphoramidase activity
APT56_01190	COG0140	phosphoribosyl-ATP diphosphatase activity
APT56_01195	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APT56_01200	COG0107	imidazoleglycerol-phosphate synthase activity
APT56_01205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APT56_01210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APT56_01215	COG0131	Imidazoleglycerol-phosphate dehydratase
APT56_01220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APT56_01225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APT56_01230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APT56_01235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APT56_01245	COG0842	Transport permease protein
APT56_01250	COG1131	(ABC) transporter
APT56_01260	COG2853	Lipoprotein
APT56_01265	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APT56_01270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APT56_01275	COG1127	ABC transporter
APT56_01290	COG0477	Major facilitator Superfamily
APT56_01305	COG0583	DNA-binding transcription factor activity
APT56_01310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
APT56_01315	COG0511	ligase activity, forming carbon-carbon bonds
APT56_01330	COG1984	allophanate hydrolase subunit 2
APT56_01345	COG2059	Chromate
APT56_01355	COG0070	glutamate synthase
APT56_01355	COG0067	glutamate synthase
APT56_01355	COG0069	glutamate synthase activity
APT56_01380	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APT56_01400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APT56_01410	COG1845	cytochrome c oxidase, subunit III
APT56_01430	COG1612	heme a metabolic process
APT56_01435	COG0109	protoheme IX farnesyltransferase activity
APT56_01440	COG1999	signal sequence binding
APT56_01460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APT56_01465	COG2814	Major facilitator Superfamily
APT56_01485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APT56_01490	COG0456	acetyltransferase
APT56_01505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APT56_01530	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APT56_01540	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APT56_01545	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
APT56_01550	COG2814	Major facilitator Superfamily
APT56_01555	COG0583	DNA-binding transcription factor activity
APT56_01560	COG2423	ornithine cyclodeaminase activity
APT56_01565	COG5001	Diguanylate cyclase
APT56_01570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APT56_01575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APT56_01585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APT56_01595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APT56_01600	COG0463	Glycosyl transferase, family 2
APT56_01640	COG0737	Belongs to the 5'-nucleotidase family
APT56_01670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
APT56_01690	COG0840	transmembrane signaling receptor activity
APT56_01695	COG2814	Major facilitator Superfamily
APT56_01710	COG3188	usher protein
APT56_01770	COG1802	Transcriptional regulator
APT56_01780	COG3069	C4-dicarboxylate transmembrane transporter activity
APT56_01785	COG1012	belongs to the aldehyde dehydrogenase family
APT56_01800	COG0589	response to stress
APT56_01805	COG4172	Belongs to the ABC transporter superfamily
APT56_01810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_01820	COG0747	negative chemotaxis
APT56_01845	COG1464	Belongs to the NlpA lipoprotein family
APT56_01850	COG0431	NADPH-dependent FMN reductase
APT56_01855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT56_01860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT56_01865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_01880	COG2011	ABC-type metal ion transport system permease component
APT56_01885	COG1464	Belongs to the NlpA lipoprotein family
APT56_01890	COG1116	anion transmembrane transporter activity
APT56_01895	COG3585	molybdate ion transport
APT56_01915	COG1607	acyl-coa hydrolase
APT56_01925	COG0243	molybdopterin cofactor binding
APT56_01925	COG3383	formate dehydrogenase (NAD+) activity
APT56_01930	COG0243	molybdopterin cofactor binding
APT56_01930	COG3383	formate dehydrogenase (NAD+) activity
APT56_01935	COG0437	4 iron, 4 sulfur cluster binding
APT56_01940	COG2864	formate dehydrogenase
APT56_01955	COG3276	selenocysteine insertion sequence binding
APT56_01965	COG1215	transferase activity, transferring glycosyl groups
APT56_01970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT56_01975	COG1305	Transglutaminase-like
APT56_01980	COG0709	Synthesizes selenophosphate from selenide and ATP
APT56_02010	COG1012	belongs to the aldehyde dehydrogenase family
APT56_02015	COG3284	Transcriptional regulator
APT56_02020	COG0134	indole-3-glycerol-phosphate synthase activity
APT56_02025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APT56_02030	COG0512	Glutamine amidotransferase of anthranilate synthase
APT56_02040	COG0546	phosphoglycolate phosphatase activity
APT56_02050	COG2967	ApaG domain
APT56_02060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT56_02065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APT56_02070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT56_02075	COG0037	tRNA processing
APT56_02090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT56_02095	COG0583	DNA-binding transcription factor activity
APT56_02100	COG3473	Maleate cis-trans isomerase
APT56_02105	COG0583	DNA-binding transcription factor activity
APT56_02120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APT56_02130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT56_02135	COG1024	Enoyl-CoA hydratase
APT56_02150	COG0356	it plays a direct role in the translocation of protons across the membrane
APT56_02160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APT56_02165	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APT56_02170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APT56_02175	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APT56_02180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APT56_02185	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APT56_02195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APT56_02200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APT56_02205	COG0210	DNA helicase
APT56_02220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APT56_02225	COG4221	oxidoreductase activity
APT56_02235	COG2171	N-acyltransferase activity
APT56_02245	COG2195	Cleaves the N-terminal amino acid of tripeptides
APT56_02255	COG4608	Belongs to the ABC transporter superfamily
APT56_02260	COG0444	Belongs to the ABC transporter superfamily
APT56_02270	COG0601	transmembrane transport
APT56_02275	COG0747	negative chemotaxis
APT56_02280	COG2988	succinylglutamate desuccinylase activity
APT56_02290	COG0583	DNA-binding transcription factor activity
APT56_02295	COG0747	negative chemotaxis
APT56_02305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APT56_02310	COG1024	Enoyl-CoA hydratase
APT56_02315	COG1024	Enoyl-CoA hydratase
APT56_02325	COG1309	transcriptional regulator
APT56_02340	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_02365	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_02370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_02385	COG0179	Fumarylacetoacetate (FAA) hydrolase
APT56_02395	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_02405	COG1129	ABC transporter
APT56_02420	COG1802	Transcriptional regulator
APT56_02430	COG0583	DNA-binding transcription factor activity
APT56_02440	COG2988	succinylglutamate desuccinylase activity
APT56_02450	COG2918	glutathione biosynthetic process
APT56_02485	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APT56_02490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT56_02500	COG2721	sulfolactate sulfo-lyase activity
APT56_02505	COG2721	sulfolactate sulfo-lyase activity
APT56_02510	COG2188	Transcriptional regulator
APT56_02515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT56_02520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT56_02520	COG2813	Specifically methylates the guanine in position
APT56_02525	COG2223	nitrite transmembrane transporter activity
APT56_02535	COG2860	membrane
APT56_02540	COG1802	Transcriptional regulator
APT56_02545	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
APT56_02550	COG1984	allophanate hydrolase subunit 2
APT56_02555	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
APT56_02575	COG1247	-acetyltransferase
APT56_02590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT56_02605	COG2132	Multicopper oxidase
APT56_02630	COG0745	RESPONSE REGULATOR receiver
APT56_02635	COG2226	methyltransferase
APT56_02650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APT56_02660	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APT56_02670	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APT56_02675	COG0351	phosphomethylpyrimidine kinase
APT56_02680	COG2022	thiamine diphosphate biosynthetic process
APT56_02685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APT56_02690	COG4771	TonB-dependent receptor
APT56_02700	COG2186	Transcriptional regulator
APT56_02715	COG1063	alcohol dehydrogenase
APT56_02725	COG0765	amino acid transport
APT56_02730	COG1126	abc transporter atp-binding protein
APT56_02735	COG4948	Mandelate Racemase Muconate Lactonizing
APT56_02740	COG0246	Mannitol dehydrogenase
APT56_02755	COG1194	a g-specific adenine glycosylase
APT56_02775	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
APT56_02780	COG2177	Part of the ABC transporter FtsEX involved in
APT56_02785	COG2884	Cell division ATP-binding protein ftsE
APT56_02790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_02795	COG4597	amino acid ABC transporter
APT56_02800	COG0765	amino acid transport
APT56_02805	COG1126	abc transporter atp-binding protein
APT56_02825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT56_02830	COG2081	HI0933 family
APT56_02840	COG1605	Chorismate mutase
APT56_02840	COG0077	Prephenate dehydratase
APT56_02870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APT56_02875	COG0477	Major facilitator Superfamily
APT56_02885	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APT56_02890	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APT56_02910	COG0237	dephospho-CoA kinase activity
APT56_02915	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
APT56_02935	COG1538	Outer membrane efflux protein
APT56_02945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_02950	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APT56_02965	COG3833	ABC-type maltose transport systems, permease component
APT56_02975	COG3842	ATPase activity
APT56_02995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APT56_03015	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_03030	COG0410	ABC transporter
APT56_03050	COG3706	GGDEF domain
APT56_03065	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_03070	COG1024	Enoyl-CoA hydratase
APT56_03110	COG4638	Rieske (2fe-2S)
APT56_03115	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
APT56_03120	COG1335	isochorismatase
APT56_03125	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_03135	COG0741	lytic transglycosylase activity
APT56_03140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APT56_03160	COG1678	Uncharacterized ACR, COG1678
APT56_03165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APT56_03185	COG1126	abc transporter atp-binding protein
APT56_03190	COG0765	amino acid transport
APT56_03200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_03210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APT56_03220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APT56_03230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APT56_03235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APT56_03245	COG3842	ATPase activity
APT56_03250	COG1175	transmembrane transport
APT56_03260	COG0642	Histidine kinase
APT56_03270	COG0557	exoribonuclease II activity
APT56_03275	COG3150	esterase
APT56_03280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APT56_03285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT56_03290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APT56_03295	COG0511	ligase activity, forming carbon-carbon bonds
APT56_03300	COG0439	Biotin carboxylase
APT56_03305	COG2264	protein methyltransferase activity
APT56_03315	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APT56_03315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APT56_03340	COG1696	Membrane protein involved in D-alanine export
APT56_03345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APT56_03375	COG1522	sequence-specific DNA binding
APT56_03380	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_03390	COG0583	DNA-binding transcription factor activity
APT56_03405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT56_03410	COG0045	succinate-CoA ligase (ADP-forming) activity
APT56_03410	COG1042	CoA-binding domain protein
APT56_03410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APT56_03415	COG1335	isochorismatase
APT56_03420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_03425	COG1116	anion transmembrane transporter activity
APT56_03440	COG3028	Belongs to the UPF0307 family
APT56_03445	COG0312	modulator of DNA gyrase
APT56_03450	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
APT56_03460	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_03465	COG4177	L-phenylalanine transmembrane transporter activity
APT56_03480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APT56_03485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APT56_03490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APT56_03500	COG0316	Belongs to the HesB IscA family
APT56_03505	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APT56_03515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APT56_03525	COG1280	lysine exporter protein (LysE YggA)
APT56_03530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APT56_03535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APT56_03550	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APT56_03550	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APT56_03565	COG2766	serine protein kinase
APT56_03570	COG2718	Belongs to the UPF0229 family
APT56_03575	COG2719	SpoVR family
APT56_03585	COG0583	DNA-binding transcription factor activity
APT56_03590	COG1942	4-Oxalocrotonate Tautomerase
APT56_03600	COG0456	acetyltransferase
APT56_03610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APT56_03665	COG4789	Type iii secretion
APT56_03740	COG4669	(LipO)protein
APT56_03770	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APT56_03775	COG4790	Type iii secretion
APT56_03780	COG4794	Type iii secretion
APT56_03785	COG4791	protein targeting
APT56_03790	COG4792	protein secretion
APT56_03820	COG2770	Histidine kinase
APT56_03820	COG2208	phosphoserine phosphatase activity
APT56_03830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APT56_03835	COG2172	sigma factor antagonist activity
APT56_03840	COG1366	Belongs to the anti-sigma-factor antagonist family
APT56_03880	COG0741	lytic transglycosylase activity
APT56_03880	COG1388	LysM domain
APT56_03885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APT56_03890	COG2226	methyltransferase
APT56_03895	COG0328	RNA-DNA hybrid ribonuclease activity
APT56_03905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT56_03910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APT56_03920	COG1671	Belongs to the UPF0178 family
APT56_03935	COG0786	glutamate:sodium symporter activity
APT56_03945	COG0463	Glycosyl transferase, family 2
APT56_03950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APT56_03965	COG0583	DNA-binding transcription factor activity
APT56_03985	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_04005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_04015	COG0583	DNA-binding transcription factor activity
APT56_04020	COG1380	Effector of murein hydrolase LrgA
APT56_04035	COG0697	spore germination
APT56_04040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_04055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APT56_04065	COG1522	sequence-specific DNA binding
APT56_04080	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
APT56_04085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT56_04100	COG0823	Involved in the tonB-independent uptake of proteins
APT56_04110	COG0848	biopolymer transport protein
APT56_04115	COG0811	peptide transport
APT56_04120	COG0824	Thioesterase
APT56_04125	COG0442	prolyl-tRNA aminoacylation
APT56_04155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT56_04165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APT56_04170	COG2084	Dehydrogenase
APT56_04175	COG0405	Gamma-glutamyltransferase
APT56_04215	COG0129	dihydroxy-acid dehydratase activity
APT56_04220	COG4654	Cytochrome c, class I
APT56_04225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT56_04235	COG1522	sequence-specific DNA binding
APT56_04280	COG1473	amidohydrolase
APT56_04285	COG0418	dihydroorotase activity
APT56_04300	COG2001	Belongs to the MraZ family
APT56_04305	COG0275	rRNA processing
APT56_04310	COG3116	cell division
APT56_04320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APT56_04325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APT56_04330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APT56_04340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APT56_04345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APT56_04350	COG1181	Belongs to the D-alanine--D-alanine ligase family
APT56_04355	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APT56_04365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APT56_04370	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APT56_04380	COG0739	heme binding
APT56_04385	COG0653	protein targeting
APT56_04400	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_04405	COG0028	Belongs to the TPP enzyme family
APT56_04415	COG0300	oxidoreductase activity
APT56_04420	COG1522	sequence-specific DNA binding
APT56_04435	COG2239	Acts as a magnesium transporter
APT56_04440	COG1607	acyl-coa hydrolase
APT56_04445	COG2855	membrane
APT56_04450	COG0583	DNA-binding transcription factor activity
APT56_04455	COG1473	amidohydrolase
APT56_04460	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_04465	COG0483	inositol monophosphate 1-phosphatase activity
APT56_04470	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
APT56_04470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_04475	COG1501	Belongs to the glycosyl hydrolase 31 family
APT56_04480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APT56_04485	COG2011	ABC-type metal ion transport system permease component
APT56_04510	COG0840	transmembrane signaling receptor activity
APT56_04515	COG0583	DNA-binding transcription factor activity
APT56_04525	COG0735	belongs to the Fur family
APT56_04545	COG2818	Glycosylase
APT56_04550	COG1368	sulfuric ester hydrolase activity
APT56_04555	COG2982	Protein involved in outer membrane biogenesis
APT56_04570	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_04600	COG2154	pterin-4-alpha-carbinolamine dehydratase
APT56_04625	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APT56_04640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT56_04645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APT56_04650	COG1929	Belongs to the glycerate kinase type-1 family
APT56_04655	COG0469	pyruvate kinase activity
APT56_04660	COG0700	Nucleoside recognition
APT56_04670	COG0242	peptide deformylase activity
APT56_04690	COG0204	Acyl-transferase
APT56_04695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APT56_04700	COG0751	glycine-tRNA ligase activity
APT56_04705	COG0752	glycyl-tRNA synthetase alpha subunit
APT56_04710	COG1024	Enoyl-CoA hydratase
APT56_04725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_04730	COG2030	dehydratase
APT56_04735	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_04755	COG2070	2-Nitropropane dioxygenase
APT56_04765	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_04770	COG0183	Belongs to the thiolase family
APT56_04780	COG1960	acyl-CoA dehydrogenase activity
APT56_04785	COG1960	acyl-CoA dehydrogenase activity
APT56_04790	COG1024	Enoyl-CoA hydratase
APT56_04800	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
APT56_04810	COG2301	Belongs to the HpcH HpaI aldolase family
APT56_04815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APT56_04825	COG0617	tRNA 3'-terminal CCA addition
APT56_04840	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APT56_04850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APT56_04855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APT56_04860	COG0586	Pfam SNARE associated Golgi protein
APT56_04870	COG0860	N-Acetylmuramoyl-L-alanine amidase
APT56_04875	COG0114	fumarate hydratase activity
APT56_04885	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_04900	COG0531	amino acid
APT56_04905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_04910	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_04915	COG1960	acyl-CoA dehydrogenase activity
APT56_04920	COG0583	DNA-binding transcription factor activity
APT56_04930	COG0579	oxidoreductase
APT56_04935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT56_04940	COG0259	pyridoxamine-phosphate oxidase activity
APT56_04955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_04960	COG1136	(ABC) transporter
APT56_04960	COG0577	efflux transmembrane transporter activity
APT56_04965	COG1538	Outer membrane efflux protein
APT56_04970	COG0583	DNA-binding transcription factor activity
APT56_04980	COG1136	(ABC) transporter
APT56_04985	COG0577	efflux transmembrane transporter activity
APT56_04985	COG1136	(ABC) transporter
APT56_04995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_05000	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APT56_05035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APT56_05045	COG0800	Aldolase
APT56_05060	COG0463	Glycosyl transferase, family 2
APT56_05060	COG1216	Glycosyl transferase, family 2
APT56_05065	COG0410	ABC transporter
APT56_05070	COG0411	ABC transporter
APT56_05085	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_05090	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
APT56_05110	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
APT56_05115	COG4638	Rieske (2fe-2S)
APT56_05140	COG0747	negative chemotaxis
APT56_05150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_05155	COG0444	Belongs to the ABC transporter superfamily
APT56_05160	COG4608	Belongs to the ABC transporter superfamily
APT56_05180	COG2746	aminoglycoside 3-N-acetyltransferase activity
APT56_05185	COG0488	(ABC) transporter
APT56_05205	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
APT56_05210	COG2894	cell division
APT56_05215	COG0850	regulation of cytokinetic process
APT56_05220	COG1414	Transcriptional regulator
APT56_05230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_05240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT56_05250	COG1294	oxidase, subunit
APT56_05255	COG0514	ATP-dependent DNA helicase (RecQ)
APT56_05265	COG0745	RESPONSE REGULATOR receiver
APT56_05275	COG2255	four-way junction helicase activity
APT56_05285	COG1090	epimerase
APT56_05290	COG0632	four-way junction helicase activity
APT56_05315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT56_05325	COG0006	proline dipeptidase activity
APT56_05340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APT56_05345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_05360	COG4783	chaperone-mediated protein folding
APT56_05400	COG2814	Major facilitator Superfamily
APT56_05415	COG0513	Belongs to the DEAD box helicase family
APT56_05435	COG1414	Transcriptional regulator
APT56_05450	COG0167	dihydroorotate dehydrogenase activity
APT56_05455	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
APT56_05460	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APT56_05470	COG0583	DNA-binding transcription factor activity
APT56_05525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APT56_05545	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APT56_05550	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APT56_05555	COG0735	belongs to the Fur family
APT56_05560	COG0497	DNA recombination
APT56_05565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APT56_05570	COG1420	regulation of RNA biosynthetic process
APT56_05575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APT56_05585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APT56_05595	COG0443	Heat shock 70 kDa protein
APT56_05600	COG0484	heat shock protein binding
APT56_05610	COG0612	Peptidase, M16
APT56_05635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT56_05665	COG3307	-O-antigen
APT56_05670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_05685	COG0745	RESPONSE REGULATOR receiver
APT56_05690	COG2205	protein histidine kinase activity
APT56_05695	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
APT56_05700	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APT56_05720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APT56_05730	COG1193	negative regulation of DNA recombination
APT56_05735	COG0492	ferredoxin-NADP+ reductase activity
APT56_05740	COG1674	ftsk spoiiie
APT56_05745	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
APT56_05750	COG0251	oxidation-reduction process
APT56_05755	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APT56_05760	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APT56_05760	COG0517	IMP dehydrogenase activity
APT56_05780	COG0601	transmembrane transport
APT56_05795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APT56_05800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APT56_05805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APT56_05840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_05860	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_05865	COG3022	response to hydroperoxide
APT56_05870	COG1289	transmembrane transporter activity
APT56_05875	COG0028	Belongs to the TPP enzyme family
APT56_05880	COG0440	acetolactate synthase activity
APT56_05885	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APT56_05890	COG1183	phosphatidylcholine synthase activity
APT56_05900	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APT56_05905	COG1185	polyribonucleotide nucleotidyltransferase activity
APT56_05915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APT56_05965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APT56_05990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_06000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT56_06020	COG0149	triose-phosphate isomerase activity
APT56_06025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APT56_06105	COG1595	DNA-templated transcription, initiation
APT56_06110	COG3712	iron ion homeostasis
APT56_06130	COG1595	DNA-templated transcription, initiation
APT56_06140	COG4206	TonB-dependent receptor
APT56_06140	COG1629	transport
APT56_06150	COG0642	Histidine kinase
APT56_06165	COG2851	Citrate transporter
APT56_06170	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_06190	COG1278	Cold shock
APT56_06205	COG3813	Protein conserved in bacteria
APT56_06210	COG2354	Protein conserved in bacteria
APT56_06225	COG4772	TonB-dependent receptor
APT56_06230	COG1522	sequence-specific DNA binding
APT56_06260	COG0747	negative chemotaxis
APT56_06280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT56_06295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APT56_06300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_06305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT56_06325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT56_06330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_06335	COG1309	transcriptional regulator
APT56_06340	COG0583	DNA-binding transcription factor activity
APT56_06360	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APT56_06385	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_06390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT56_06395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT56_06400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT56_06405	COG0649	NAD binding
APT56_06410	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APT56_06420	COG1034	ATP synthesis coupled electron transport
APT56_06425	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APT56_06430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT56_06440	COG0713	ATP synthesis coupled electron transport
APT56_06455	COG1007	ATP synthesis coupled electron transport
APT56_06465	COG4774	siderophore transport
APT56_06470	COG0560	Phosphoserine phosphatase
APT56_06475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APT56_06480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APT56_06485	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APT56_06495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT56_06500	COG0450	alkyl hydroperoxide reductase
APT56_06505	COG2205	protein histidine kinase activity
APT56_06510	COG0745	RESPONSE REGULATOR receiver
APT56_06515	COG1214	PFAM Peptidase M22, glycoprotease
APT56_06520	COG1573	uracil-dna glycosylase
APT56_06525	COG0477	Major facilitator Superfamily
APT56_06530	COG1196	nuclear chromosome segregation
APT56_06540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APT56_06545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT56_06555	COG2917	probably involved in intracellular septation
APT56_06560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT56_06565	COG1122	ATPase activity
APT56_06570	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APT56_06575	COG1268	BioY protein
APT56_06590	COG0411	ABC transporter
APT56_06610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APT56_06640	COG0411	ABC transporter
APT56_06645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APT56_06650	COG2878	Part of a membrane complex involved in electron transport
APT56_06665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APT56_06670	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APT56_06675	COG0251	oxidation-reduction process
APT56_06685	COG3228	Belongs to the MtfA family
APT56_06690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APT56_06700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT56_06705	COG0133	tryptophan synthase activity
APT56_06710	COG0159	tryptophan synthase activity
APT56_06715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APT56_06720	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APT56_06725	COG1530	ribonuclease E activity
APT56_06730	COG0564	pseudouridine synthase activity
APT56_06735	COG0546	phosphoglycolate phosphatase activity
APT56_06740	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APT56_06745	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
APT56_06760	COG0424	maF-like protein
APT56_06765	COG1399	metal-binding, possibly nucleic acid-binding protein
APT56_06770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APT56_06775	COG0416	fatty acid biosynthetic process
APT56_06780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APT56_06785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APT56_06795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APT56_06800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT56_06825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT56_06830	COG0481	GTPase activity
APT56_06835	COG0681	Belongs to the peptidase S26 family
APT56_06840	COG0571	ribonuclease III activity
APT56_06845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APT56_06850	COG1381	Involved in DNA repair and RecF pathway recombination
APT56_06860	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APT56_06880	COG0667	Aldo Keto reductase
APT56_06900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APT56_06925	COG0583	DNA-binding transcription factor activity
APT56_06935	COG0791	NLP P60 protein
APT56_06945	COG3193	protein, possibly involved in utilization of glycolate and propanediol
APT56_06960	COG0697	spore germination
APT56_06965	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
APT56_07005	COG2153	protein acetylation
APT56_07015	COG1446	asparaginase
APT56_07020	COG4172	Belongs to the ABC transporter superfamily
APT56_07025	COG0747	negative chemotaxis
APT56_07035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_07060	COG0504	CTP synthase activity
APT56_07070	COG0148	phosphopyruvate hydratase activity
APT56_07085	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APT56_07095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APT56_07150	COG0039	L-malate dehydrogenase activity
APT56_07155	COG2188	Transcriptional regulator
APT56_07160	COG2009	succinate dehydrogenase
APT56_07165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
APT56_07170	COG1053	succinate dehydrogenase
APT56_07175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APT56_07180	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APT56_07185	COG0372	Belongs to the citrate synthase family
APT56_07200	COG0280	phosphate acetyltransferase
APT56_07200	COG0281	malic enzyme
APT56_07210	COG1297	OPT oligopeptide transporter protein
APT56_07215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT56_07230	COG2515	1-aminocyclopropane-1-carboxylate deaminase
APT56_07235	COG1522	sequence-specific DNA binding
APT56_07240	COG0567	Dehydrogenase, E1 component
APT56_07245	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT56_07250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT56_07255	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APT56_07260	COG1595	DNA-templated transcription, initiation
APT56_07265	COG3712	iron ion homeostasis
APT56_07270	COG4774	siderophore transport
APT56_07295	COG0180	Tryptophanyl-tRNA synthetase
APT56_07305	COG2183	response to ionizing radiation
APT56_07310	COG1199	ATP-dependent helicase activity
APT56_07320	COG0564	pseudouridine synthase activity
APT56_07330	COG3243	poly(R)-hydroxyalkanoic acid synthase
APT56_07335	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_07340	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
APT56_07365	COG2831	hemolysin activation secretion protein
APT56_07390	COG2823	Periplasmic or secreted lipoprotein
APT56_07395	COG3237	CsbD-like
APT56_07400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APT56_07400	COG0189	ligase activity
APT56_07405	COG0189	ligase activity
APT56_07405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APT56_07410	COG1132	(ABC) transporter
APT56_07425	COG2833	Protein of unknown function (DUF455)
APT56_07430	COG2258	MOSC domain
APT56_07435	COG2951	lytic endotransglycosylase activity
APT56_07450	COG1960	acyl-CoA dehydrogenase activity
APT56_07460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APT56_07470	COG1696	Membrane protein involved in D-alanine export
APT56_07490	COG1215	transferase activity, transferring glycosyl groups
APT56_07500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APT56_07525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT56_07540	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APT56_07560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APT56_07565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APT56_07585	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APT56_07590	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APT56_07595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT56_07625	COG2951	lytic endotransglycosylase activity
APT56_07630	COG0123	including yeast histone deacetylase and acetoin utilization protein
APT56_07655	COG2985	domain, Protein
APT56_07660	COG1960	acyl-CoA dehydrogenase activity
APT56_07665	COG0450	alkyl hydroperoxide reductase
APT56_07675	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APT56_07680	COG4208	sulfate ABC transporter
APT56_07690	COG0175	sulfate reduction
APT56_07720	COG0335	large ribosomal subunit rRNA binding
APT56_07730	COG1162	GTPase activity
APT56_07735	COG0501	Belongs to the peptidase M48B family
APT56_07740	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APT56_07745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APT56_07750	COG3327	negative regulation of DNA-templated transcription, initiation
APT56_07755	COG3396	Phenylacetate-CoA oxygenase
APT56_07760	COG3460	Phenylacetate-CoA oxygenase
APT56_07765	COG3396	Phenylacetate-CoA oxygenase
APT56_07770	COG2151	metal-sulfur cluster biosynthetic enzyme
APT56_07775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APT56_07780	COG1012	belongs to the aldehyde dehydrogenase family
APT56_07785	COG1024	Enoyl-CoA hydratase
APT56_07790	COG2050	protein possibly involved in aromatic compounds catabolism
APT56_07800	COG0534	Mate efflux family protein
APT56_07810	COG0254	rRNA binding
APT56_07815	COG3483	tryptophan 2,3-dioxygenase activity
APT56_07820	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
APT56_07825	COG2003	Belongs to the UPF0758 family
APT56_07840	COG0625	glutathione transferase activity
APT56_07845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT56_07855	COG0745	RESPONSE REGULATOR receiver
APT56_07870	COG0523	cobalamin synthesis protein
APT56_07875	COG0523	cobalamin synthesis protein
APT56_07880	COG0583	DNA-binding transcription factor activity
APT56_07890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APT56_07895	COG1187	pseudouridine synthase activity
APT56_07900	COG0779	Required for maturation of 30S ribosomal subunits
APT56_07905	COG0195	Participates in both transcription termination and antitermination
APT56_07905	COG2251	uridine kinase activity
APT56_07910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APT56_07915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APT56_07920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APT56_07945	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_07950	COG1473	amidohydrolase
APT56_07955	COG1611	Belongs to the LOG family
APT56_07960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APT56_07960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APT56_07970	COG0412	Dienelactone hydrolase
APT56_07975	COG1283	sodium-dependent phosphate transmembrane transporter activity
APT56_07980	COG1760	l-serine dehydratase
APT56_07985	COG0501	Belongs to the peptidase M48B family
APT56_08005	COG0583	DNA-binding transcription factor activity
APT56_08010	COG3842	ATPase activity
APT56_08020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT56_08025	COG1840	ABC-type Fe3 transport system, periplasmic component
APT56_08045	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_08055	COG1722	exodeoxyribonuclease VII activity
APT56_08060	COG0142	geranyltranstransferase activity
APT56_08065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APT56_08070	COG1469	GTP cyclohydrolase I activity
APT56_08075	COG3739	integral membrane protein
APT56_08080	COG0360	Binds together with S18 to 16S ribosomal RNA
APT56_08085	COG2965	DNA replication, synthesis of RNA primer
APT56_08090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APT56_08095	COG0359	binds to the 23S rRNA
APT56_08105	COG0305	Participates in initiation and elongation during chromosome replication
APT56_08115	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APT56_08150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_08170	COG0493	'glutamate synthase
APT56_08200	COG0540	Belongs to the ATCase OTCase family
APT56_08225	COG0642	Histidine kinase
APT56_08235	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APT56_08240	COG2137	regulation of response to DNA damage stimulus
APT56_08245	COG0583	DNA-binding transcription factor activity
APT56_08250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APT56_08255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APT56_08265	COG0045	succinate-CoA ligase (ADP-forming) activity
APT56_08270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APT56_08275	COG0861	Integral membrane protein TerC family
APT56_08280	COG0861	Integral membrane protein TerC family
APT56_08285	COG0181	hydroxymethylbilane synthase activity
APT56_08305	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APT56_08315	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_08330	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_08335	COG0411	ABC transporter
APT56_08345	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_08365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
APT56_08370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APT56_08380	COG0436	Aminotransferase
APT56_08400	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APT56_08405	COG0308	aminopeptidase N
APT56_08420	COG0312	modulator of DNA gyrase
APT56_08425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APT56_08430	COG0277	FAD linked oxidase domain protein
APT56_08435	COG0277	FAD linked oxidase domain protein
APT56_08440	COG0277	FAD linked oxidase domain protein
APT56_08445	COG0247	lactate metabolic process
APT56_08450	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APT56_08455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APT56_08460	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APT56_08475	COG0583	DNA-binding transcription factor activity
APT56_08480	COG0482	sulfurtransferase activity
APT56_08485	COG0730	response to heat
APT56_08490	COG0625	glutathione transferase activity
APT56_08500	COG3909	cytochrome
APT56_08540	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
APT56_08660	COG0697	spore germination
APT56_08695	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
APT56_08705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APT56_08710	COG0069	glutamate synthase activity
APT56_08715	COG2391	methyltransferase activity
APT56_08720	COG0679	Auxin Efflux Carrier
APT56_08730	COG2153	protein acetylation
APT56_08750	COG0557	exoribonuclease II activity
APT56_08755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APT56_08765	COG3128	pkhd-type hydroxylase
APT56_08770	COG0776	regulation of translation
APT56_08795	COG0745	RESPONSE REGULATOR receiver
APT56_08800	COG0642	Histidine kinase
APT56_08805	COG3158	transport of potassium into the cell
APT56_08820	COG0137	argininosuccinate synthase activity
APT56_08825	COG1538	Outer membrane efflux protein
APT56_08835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT56_08845	COG5002	protein histidine kinase activity
APT56_08850	COG0583	DNA-binding transcription factor activity
APT56_08855	COG3618	amidohydrolase
APT56_08875	COG0596	Alpha beta hydrolase
APT56_08875	COG2945	thiolester hydrolase activity
APT56_08880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APT56_08885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APT56_08915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_08935	COG4608	Belongs to the ABC transporter superfamily
APT56_08950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT56_08955	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
APT56_08965	COG3642	lipopolysaccharide core region biosynthetic process
APT56_08975	COG3842	ATPase activity
APT56_08980	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT56_08985	COG1177	transmembrane transport
APT56_09015	COG1960	acyl-CoA dehydrogenase activity
APT56_09025	COG0704	Plays a role in the regulation of phosphate uptake
APT56_09035	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
APT56_09040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
APT56_09040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APT56_09045	COG1643	Atp-dependent helicase
APT56_09050	COG0395	ABC-type sugar transport system, permease component
APT56_09055	COG1116	anion transmembrane transporter activity
APT56_09070	COG0438	transferase activity, transferring glycosyl groups
APT56_09075	COG0726	polysaccharide deacetylase
APT56_09090	COG0726	polysaccharide deacetylase
APT56_09115	COG1132	(ABC) transporter
APT56_09120	COG0475	glutathione-regulated potassium exporter activity
APT56_09120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APT56_09135	COG3706	GGDEF domain
APT56_09135	COG2203	Gaf domain
APT56_09135	COG4251	negative regulation of phosphorylation
APT56_09135	COG5001	Diguanylate cyclase
APT56_09145	COG1530	ribonuclease E activity
APT56_09175	COG2204	response regulator
APT56_09180	COG4191	Histidine kinase
APT56_09185	COG1301	dicarboxylic acid transport
APT56_09190	COG0424	maF-like protein
APT56_09195	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APT56_09200	COG0799	negative regulation of ribosome biogenesis
APT56_09205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APT56_09210	COG0408	coproporphyrinogen oxidase activity
APT56_09215	COG0151	Belongs to the GarS family
APT56_09220	COG0217	transcriptional regulatory protein
APT56_09225	COG0433	COG0433 Predicted ATPase
APT56_09230	COG0473	3-isopropylmalate dehydrogenase activity
APT56_09240	COG2814	Major facilitator Superfamily
APT56_09245	COG1566	PFAM secretion protein HlyD family protein
APT56_09255	COG1846	Transcriptional regulator
APT56_09285	COG3391	amine dehydrogenase activity
APT56_09295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APT56_09315	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APT56_09320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
APT56_09335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APT56_09345	COG0187	DNA topoisomerase II activity
APT56_09360	COG1309	transcriptional regulator
APT56_09365	COG2311	Membrane
APT56_09370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APT56_09390	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APT56_09395	COG0662	Cupin 2, conserved barrel domain protein
APT56_09400	COG5285	phytanoyl-CoA dioxygenase
APT56_09405	COG0633	Ferredoxin
APT56_09405	COG3217	Mosc domain protein beta barrel domain protein
APT56_09410	COG2076	Multidrug Resistance protein
APT56_09415	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APT56_09425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_09440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APT56_09445	COG0425	Belongs to the sulfur carrier protein TusA family
APT56_09455	COG0228	four-way junction DNA binding
APT56_09460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APT56_09465	COG0336	Belongs to the RNA methyltransferase TrmD family
APT56_09470	COG1396	sequence-specific DNA binding
APT56_09475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_09480	COG0765	amino acid transport
APT56_09490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_09495	COG0525	valine-tRNA ligase activity
APT56_09500	COG0105	UTP biosynthetic process
APT56_09505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APT56_09515	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APT56_09520	COG0124	histidyl-tRNA synthetase
APT56_09525	COG2976	Protein conserved in bacteria
APT56_09530	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APT56_09535	COG1160	GTP binding
APT56_09540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APT56_09545	COG1923	regulation of RNA biosynthetic process
APT56_09550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APT56_09555	COG0330	HflC and HflK could
APT56_09560	COG0330	HflC and HflK could
APT56_09565	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APT56_09570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APT56_09575	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APT56_09580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APT56_09605	COG0438	transferase activity, transferring glycosyl groups
APT56_09620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APT56_09620	COG2755	lipolytic protein G-D-S-L family
APT56_09650	COG4964	Belongs to the GSP D family
APT56_09680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APT56_09690	COG1295	ribonuclease BN
APT56_09700	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APT56_09725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APT56_09730	COG4783	chaperone-mediated protein folding
APT56_09760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_09765	COG2274	protein secretion by the type I secretion system
APT56_09775	COG1538	Outer membrane efflux protein
APT56_09780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APT56_09785	COG0066	3-isopropylmalate dehydratase activity
APT56_09790	COG0473	3-isopropylmalate dehydrogenase activity
APT56_09795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APT56_09805	COG0101	tRNA pseudouridine synthase activity
APT56_09810	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
APT56_09815	COG0135	phosphoribosylanthranilate isomerase activity
APT56_09860	COG2755	lipolytic protein G-D-S-L family
APT56_09860	COG0657	acetylesterase activity
APT56_09865	COG0129	dihydroxy-acid dehydratase activity
APT56_09870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT56_09875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APT56_09880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APT56_09885	COG1609	Transcriptional regulator
APT56_09910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_09915	COG0601	transmembrane transport
APT56_09925	COG1012	belongs to the aldehyde dehydrogenase family
APT56_09955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APT56_09960	COG2197	response regulator
APT56_09970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APT56_09975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APT56_09980	COG0189	ligase activity
APT56_09990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT56_09995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APT56_10000	COG0004	ammonium transporteR
APT56_10005	COG0347	Belongs to the P(II) protein family
APT56_10015	COG2960	long-chain fatty acid transporting porin activity
APT56_10025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APT56_10030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APT56_10035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APT56_10040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT56_10040	COG0072	phenylalanine-tRNA ligase activity
APT56_10045	COG0776	regulation of translation
APT56_10065	COG1475	DNA binding
APT56_10075	COG3723	Recombinational DNA repair protein, rece pathway
APT56_10080	COG5377	YqaJ viral recombinase family
APT56_10125	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
APT56_10145	COG5410	chromosome segregation
APT56_10155	COG2369	cell adhesion
APT56_10325	COG0384	phenazine biosynthesis protein PhzF
APT56_10375	COG1522	sequence-specific DNA binding
APT56_10405	COG0583	DNA-binding transcription factor activity
APT56_10410	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_10435	COG1116	anion transmembrane transporter activity
APT56_10465	COG5265	(ABC) transporter
APT56_10485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APT56_10500	COG2223	nitrite transmembrane transporter activity
APT56_10510	COG1215	transferase activity, transferring glycosyl groups
APT56_10515	COG1649	PFAM Uncharacterised BCR, COG1649
APT56_10515	COG0726	polysaccharide deacetylase
APT56_10520	COG0457	Tetratricopeptide repeat
APT56_10550	COG1610	YqeY-like protein
APT56_10560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT56_10565	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_10575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT56_10615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APT56_10625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APT56_10630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APT56_10650	COG1017	nitric oxide dioxygenase activity
APT56_10650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APT56_10655	COG1959	2 iron, 2 sulfur cluster binding
APT56_10660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_10665	COG0697	spore germination
APT56_10670	COG0506	proline dehydrogenase activity
APT56_10690	COG0583	DNA-binding transcription factor activity
APT56_10695	COG2814	Major facilitator Superfamily
APT56_10705	COG0583	DNA-binding transcription factor activity
APT56_10710	COG0625	glutathione transferase activity
APT56_10725	COG2814	Major facilitator Superfamily
APT56_10730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APT56_10750	COG1960	acyl-CoA dehydrogenase activity
APT56_10755	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_10775	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APT56_10780	COG1280	lysine exporter protein (LysE YggA)
APT56_10795	COG1280	lysine exporter protein (LysE YggA)
APT56_10810	COG0697	spore germination
APT56_10815	COG0697	spore germination
APT56_10830	COG0534	Mate efflux family protein
APT56_10835	COG1024	Enoyl-CoA hydratase
APT56_10840	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_10850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APT56_10855	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
APT56_10865	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_10900	COG2207	Transcriptional regulator
APT56_10905	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_10910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT56_10915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APT56_10935	COG1063	alcohol dehydrogenase
APT56_10945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT56_10960	COG4172	Belongs to the ABC transporter superfamily
APT56_10985	COG0583	DNA-binding transcription factor activity
APT56_10990	COG5002	protein histidine kinase activity
APT56_10990	COG3447	MASE1 domain protein
APT56_10990	COG5001	Diguanylate cyclase
APT56_11010	COG3088	subunit of a heme lyase
APT56_11015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT56_11025	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
APT56_11040	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APT56_11045	COG4133	protoheme IX ABC transporter activity
APT56_11050	COG3005	denitrification pathway
APT56_11060	COG3381	protein complex oligomerization
APT56_11080	COG3246	L-lysine catabolic process to acetate
APT56_11085	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_11090	COG0583	DNA-binding transcription factor activity
APT56_11100	COG0129	dihydroxy-acid dehydratase activity
APT56_11105	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_11110	COG5001	Diguanylate cyclase
APT56_11115	COG1024	Enoyl-CoA hydratase
APT56_11155	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
APT56_11160	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_11165	COG0583	DNA-binding transcription factor activity
APT56_11170	COG2610	gluconate transmembrane transporter activity
APT56_11210	COG0235	Class ii aldolase
APT56_11215	COG0477	Major facilitator Superfamily
APT56_11235	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_11280	COG5265	(ABC) transporter
APT56_11290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT56_11310	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_11325	COG2059	Chromate
APT56_11345	COG1132	(ABC) transporter
APT56_11350	COG0583	DNA-binding transcription factor activity
APT56_11365	COG0583	DNA-binding transcription factor activity
APT56_11380	COG2814	Major facilitator Superfamily
APT56_11405	COG2814	Major facilitator Superfamily
APT56_11410	COG0154	amidase activity
APT56_11460	COG2070	2-Nitropropane dioxygenase
APT56_11490	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_11495	COG2186	Transcriptional regulator
APT56_11505	COG0307	riboflavin synthase, alpha
APT56_11515	COG2271	Major facilitator Superfamily
APT56_11525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APT56_11535	COG0789	Transcriptional regulator
APT56_11560	COG4774	siderophore transport
APT56_11570	COG0022	dehydrogenase e1 component
APT56_11590	COG0165	Argininosuccinate lyase
APT56_11595	COG0668	transmembrane transport
APT56_11610	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
APT56_11680	COG2165	general secretion pathway protein
APT56_11715	COG0583	DNA-binding transcription factor activity
APT56_11725	COG0747	negative chemotaxis
APT56_11730	COG0601	transmembrane transport
APT56_11740	COG4172	Belongs to the ABC transporter superfamily
APT56_11745	COG4681	YaeQ
APT56_11765	COG0477	Major facilitator Superfamily
APT56_11770	COG3161	chorismate lyase activity
APT56_11775	COG1187	pseudouridine synthase activity
APT56_11780	COG0583	DNA-binding transcription factor activity
APT56_11795	COG1538	Outer membrane efflux protein
APT56_11800	COG2261	transglycosylase associated protein
APT56_11805	COG1999	signal sequence binding
APT56_11815	COG0339	signal peptide processing
APT56_11825	COG4566	intracellular signal transduction
APT56_11840	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT56_11845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT56_11875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APT56_11875	COG4797	methyltransferase
APT56_11880	COG1191	sigma factor activity
APT56_11915	COG0835	chemotaxis
APT56_11920	COG0840	transmembrane signaling receptor activity
APT56_11925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APT56_11930	COG2201	protein-glutamate methylesterase activity
APT56_11935	COG0745	RESPONSE REGULATOR receiver
APT56_11940	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
APT56_11945	COG0840	transmembrane signaling receptor activity
APT56_11970	COG2747	anti-sigma28 factor FlgM
APT56_11985	COG1558	bacterial-type flagellum-dependent cell motility
APT56_11990	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
APT56_11995	COG1749	Flagellar hook protein flgE
APT56_12000	COG4787	bacterial-type flagellum-dependent cell motility
APT56_12005	COG4786	Flagellar basal body rod
APT56_12010	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
APT56_12015	COG1706	bacterial-type flagellum-dependent cell motility
APT56_12025	COG1256	bacterial-type flagellum assembly
APT56_12035	COG0840	transmembrane signaling receptor activity
APT56_12040	COG0840	transmembrane signaling receptor activity
APT56_12050	COG0840	transmembrane signaling receptor activity
APT56_12055	COG0840	transmembrane signaling receptor activity
APT56_12080	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APT56_12090	COG1580	Controls the rotational direction of flagella during chemotaxis
APT56_12115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APT56_12120	COG1766	The M ring may be actively involved in energy transduction
APT56_12125	COG1677	Flagellar hook-basal body complex protein FliE
APT56_12135	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APT56_12155	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
APT56_12175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_12180	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_12190	COG0285	dihydrofolate synthase activity
APT56_12200	COG1286	toxin biosynthetic process
APT56_12210	COG1451	nucleotide metabolic process
APT56_12220	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APT56_12230	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
APT56_12235	COG0024	Methionine aminopeptidase
APT56_12240	COG0052	Belongs to the universal ribosomal protein uS2 family
APT56_12245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APT56_12250	COG0528	UMP kinase activity
APT56_12255	COG0233	cytoplasmic translational termination
APT56_12260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APT56_12270	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APT56_12275	COG0750	zinc metalloprotease
APT56_12280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APT56_12285	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
APT56_12290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT56_12295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APT56_12305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT56_12310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APT56_12315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APT56_12335	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
APT56_12345	COG4774	siderophore transport
APT56_12360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APT56_12360	COG2169	Transcriptional regulator
APT56_12365	COG0519	Catalyzes the synthesis of GMP from XMP
APT56_12365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APT56_12380	COG3706	GGDEF domain
APT56_12385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APT56_12390	COG2867	negative regulation of translational initiation
APT56_12395	COG2914	Belongs to the UPF0125 (RnfH) family
APT56_12405	COG1024	Enoyl-CoA hydratase
APT56_12405	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_12430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APT56_12435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APT56_12440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APT56_12445	COG0084	hydrolase, TatD family'
APT56_12460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_12470	COG1126	abc transporter atp-binding protein
APT56_12475	COG0010	Belongs to the arginase family
APT56_12485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APT56_12495	COG0095	Lipoate-protein ligase
APT56_12510	COG0625	glutathione transferase activity
APT56_12520	COG1522	sequence-specific DNA binding
APT56_12525	COG0386	Belongs to the glutathione peroxidase family
APT56_12530	COG2814	Major facilitator Superfamily
APT56_12560	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APT56_12570	COG0840	transmembrane signaling receptor activity
APT56_12580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_12600	COG0513	Belongs to the DEAD box helicase family
APT56_12605	COG1414	Transcriptional regulator
APT56_12620	COG0747	negative chemotaxis
APT56_12625	COG0601	transmembrane transport
APT56_12630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_12640	COG1228	amidohydrolase
APT56_12675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_12680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APT56_12685	COG4521	taurine ABC transporter
APT56_12690	COG0583	DNA-binding transcription factor activity
APT56_12695	COG0697	spore germination
APT56_12715	COG1966	Carbon starvation protein
APT56_12720	COG2879	small protein
APT56_12725	COG0697	spore germination
APT56_12730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_12750	COG0783	Belongs to the Dps family
APT56_12765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT56_12770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT56_12780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APT56_12785	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
APT56_12790	COG0745	RESPONSE REGULATOR receiver
APT56_12795	COG5002	protein histidine kinase activity
APT56_12800	COG2070	2-Nitropropane dioxygenase
APT56_12820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_12850	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_12860	COG0583	DNA-binding transcription factor activity
APT56_12870	COG0583	DNA-binding transcription factor activity
APT56_12895	COG2223	nitrite transmembrane transporter activity
APT56_12900	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
APT56_12905	COG1140	nitrate reductase beta subunit
APT56_12910	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
APT56_12915	COG2181	nitrate reductase activity
APT56_12920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT56_12925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APT56_12930	COG0288	reversible hydration of carbon dioxide
APT56_12935	COG1763	Mo-molybdopterin cofactor biosynthetic process
APT56_12940	COG3850	Histidine kinase
APT56_12945	COG2197	response regulator
APT56_12965	COG4597	amino acid ABC transporter
APT56_12970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_13005	COG1116	anion transmembrane transporter activity
APT56_13010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT56_13015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_13040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APT56_13055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_13060	COG1802	Transcriptional regulator
APT56_13105	COG0251	oxidation-reduction process
APT56_13130	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
APT56_13155	COG0277	FAD linked oxidase domain protein
APT56_13165	COG0765	amino acid transport
APT56_13195	COG0583	DNA-binding transcription factor activity
APT56_13260	COG4566	intracellular signal transduction
APT56_13265	COG4191	Histidine kinase
APT56_13280	COG0583	DNA-binding transcription factor activity
APT56_13285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APT56_13315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APT56_13325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT56_13330	COG2070	2-Nitropropane dioxygenase
APT56_13340	COG0765	amino acid transport
APT56_13350	COG1120	ATPase activity
APT56_13355	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT56_13360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT56_13365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APT56_13410	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APT56_13415	COG0390	transport system, permease component
APT56_13420	COG0586	Pfam SNARE associated Golgi protein
APT56_13435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APT56_13440	COG1120	ATPase activity
APT56_13445	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
APT56_13450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT56_13460	COG0745	RESPONSE REGULATOR receiver
APT56_13475	COG1126	abc transporter atp-binding protein
APT56_13480	COG0765	amino acid transport
APT56_13485	COG4597	amino acid ABC transporter
APT56_13495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_13500	COG2188	Transcriptional regulator
APT56_13520	COG2721	sulfolactate sulfo-lyase activity
APT56_13525	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_13545	COG1276	copper resistance
APT56_13555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APT56_13555	COG0519	Catalyzes the synthesis of GMP from XMP
APT56_13570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_13575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_13590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APT56_13600	COG4208	sulfate ABC transporter
APT56_13605	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APT56_13610	COG4150	thiosulfate binding
APT56_13620	COG4771	TonB-dependent receptor
APT56_13630	COG1126	abc transporter atp-binding protein
APT56_13650	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
APT56_13660	COG1640	4-alpha-glucanotransferase
APT56_13665	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APT56_13675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APT56_13680	COG0366	Alpha amylase catalytic
APT56_13685	COG0366	Alpha amylase catalytic
APT56_13690	COG0297	glycogen (starch) synthase activity
APT56_13695	COG0392	lysyltransferase activity
APT56_13700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APT56_13705	COG3568	Endonuclease Exonuclease Phosphatase
APT56_13710	COG0387	Pfam Sodium calcium exchanger
APT56_13720	COG3685	Protein conserved in bacteria
APT56_13730	COG0166	Belongs to the GPI family
APT56_13740	COG0668	transmembrane transport
APT56_13760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APT56_13770	COG0589	response to stress
APT56_13780	COG0589	response to stress
APT56_13790	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
APT56_13795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
APT56_13800	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
APT56_13820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT56_13835	COG0589	response to stress
APT56_13840	COG1914	H( )-stimulated, divalent metal cation uptake system
APT56_13865	COG0071	Belongs to the small heat shock protein (HSP20) family
APT56_13890	COG1280	lysine exporter protein (LysE YggA)
APT56_13910	COG0579	oxidoreductase
APT56_13920	COG0477	Major facilitator Superfamily
APT56_13935	COG0625	glutathione transferase activity
APT56_13965	COG3971	2-oxopent-4-enoate hydratase activity
APT56_13990	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
APT56_14005	COG0179	Fumarylacetoacetate (FAA) hydrolase
APT56_14025	COG0251	oxidation-reduction process
APT56_14035	COG0747	negative chemotaxis
APT56_14040	COG0601	transmembrane transport
APT56_14050	COG0444	Belongs to the ABC transporter superfamily
APT56_14055	COG4608	Belongs to the ABC transporter superfamily
APT56_14060	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APT56_14070	COG0531	amino acid
APT56_14095	COG0628	permease
APT56_14155	COG3706	GGDEF domain
APT56_14165	COG0789	Transcriptional regulator
APT56_14170	COG3706	GGDEF domain
APT56_14225	COG2205	protein histidine kinase activity
APT56_14235	COG1253	flavin adenine dinucleotide binding
APT56_14285	COG3300	MHYT domain
APT56_14285	COG5001	Diguanylate cyclase
APT56_14290	COG1289	transmembrane transporter activity
APT56_14300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT56_14310	COG0693	protein deglycase activity
APT56_14330	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_14365	COG2204	response regulator
APT56_14370	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
APT56_14395	COG2814	Major facilitator Superfamily
APT56_14410	COG3300	MHYT domain
APT56_14410	COG5001	Diguanylate cyclase
APT56_14415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APT56_14420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_14445	COG0488	(ABC) transporter
APT56_14455	COG0688	phosphatidylethanolamine metabolic process
APT56_14485	COG1408	metallophosphoesterase
APT56_14495	COG2814	Major facilitator Superfamily
APT56_14505	COG1464	Belongs to the NlpA lipoprotein family
APT56_14510	COG0010	Belongs to the arginase family
APT56_14530	COG2363	Small membrane protein
APT56_14535	COG0697	spore germination
APT56_14545	COG2133	pyrroloquinoline quinone binding
APT56_14550	COG0625	glutathione transferase activity
APT56_14555	COG0583	DNA-binding transcription factor activity
APT56_14565	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APT56_14580	COG0410	ABC transporter
APT56_14595	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_14605	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APT56_14615	COG1653	transport
APT56_14620	COG1175	transmembrane transport
APT56_14625	COG0395	ABC-type sugar transport system, permease component
APT56_14630	COG3842	ATPase activity
APT56_14645	COG2205	protein histidine kinase activity
APT56_14650	COG0745	RESPONSE REGULATOR receiver
APT56_14665	COG3866	Pectate lyase
APT56_14670	COG4783	chaperone-mediated protein folding
APT56_14670	COG1560	Kdo2-lipid A biosynthetic process
APT56_14695	COG0438	transferase activity, transferring glycosyl groups
APT56_14700	COG0457	Tetratricopeptide repeat
APT56_14710	COG0783	Belongs to the Dps family
APT56_14720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APT56_14740	COG0583	DNA-binding transcription factor activity
APT56_14755	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_14765	COG1840	ABC-type Fe3 transport system, periplasmic component
APT56_14770	COG4149	molybdate abc transporter
APT56_14775	COG3842	ATPase activity
APT56_14785	COG1690	Belongs to the RtcB family
APT56_14790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APT56_14795	COG1741	Belongs to the pirin family
APT56_14800	COG1741	Belongs to the pirin family
APT56_14805	COG0583	DNA-binding transcription factor activity
APT56_14810	COG2204	response regulator
APT56_14815	COG3852	Histidine kinase
APT56_14825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APT56_14830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APT56_14855	COG1960	acyl-CoA dehydrogenase activity
APT56_14865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APT56_14870	COG1561	YicC-like family, N-terminal region
APT56_14875	COG0833	amino acid
APT56_14880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APT56_14895	COG0791	NLP P60 protein
APT56_14905	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_14910	COG2863	cytochrome
APT56_14915	COG3258	Cytochrome c
APT56_14920	COG0194	GDP metabolic process
APT56_14925	COG1758	RNA polymerase activity
APT56_14930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APT56_14935	COG1126	abc transporter atp-binding protein
APT56_14940	COG0765	amino acid transport
APT56_14945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_14965	COG2816	NAD+ diphosphatase activity
APT56_14985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_14990	COG0410	ABC transporter
APT56_14995	COG0411	ABC transporter
APT56_15005	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_15015	COG4336	lyase activity
APT56_15020	COG0583	DNA-binding transcription factor activity
APT56_15035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APT56_15050	COG0583	DNA-binding transcription factor activity
APT56_15060	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APT56_15065	COG0560	Phosphoserine phosphatase
APT56_15070	COG0583	DNA-binding transcription factor activity
APT56_15075	COG3842	ATPase activity
APT56_15080	COG1178	ABC-type Fe3 transport system permease component
APT56_15090	COG4181	ATPase activity
APT56_15100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT56_15110	COG0584	glycerophosphoryl diester phosphodiesterase
APT56_15115	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APT56_15125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APT56_15125	COG0678	peroxiredoxin activity
APT56_15140	COG0789	Transcriptional regulator
APT56_15145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APT56_15170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APT56_15175	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APT56_15180	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APT56_15185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APT56_15190	COG2252	PERMEase
APT56_15200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT56_15205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT56_15230	COG1116	anion transmembrane transporter activity
APT56_15235	COG2814	Major facilitator Superfamily
APT56_15240	COG0488	(ABC) transporter
APT56_15245	COG1619	proteins homologs of microcin C7 resistance protein MccF
APT56_15250	COG0590	tRNA wobble adenosine to inosine editing
APT56_15265	COG1320	monovalent cation:proton antiporter activity
APT56_15270	COG2212	antiporter activity
APT56_15275	COG1863	multisubunit Na H antiporter MnhE subunit
APT56_15280	COG0651	ATP synthesis coupled electron transport
APT56_15285	COG1006	Multisubunit Na H antiporter MnhC subunit
APT56_15290	COG2111	Na H antiporter
APT56_15290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APT56_15315	COG0420	3'-5' exonuclease activity
APT56_15320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_15355	COG1960	acyl-CoA dehydrogenase activity
APT56_15360	COG1959	2 iron, 2 sulfur cluster binding
APT56_15365	COG3634	alkyl hydroperoxide reductase activity
APT56_15390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_15425	COG0395	ABC-type sugar transport system, permease component
APT56_15435	COG3842	ATPase activity
APT56_15440	COG3842	ATPase activity
APT56_15465	COG2130	NADP-dependent
APT56_15480	COG1131	(ABC) transporter
APT56_15485	COG0842	Transport permease protein
APT56_15500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APT56_15530	COG1902	pentaerythritol trinitrate reductase activity
APT56_15545	COG0602	queuosine metabolic process
APT56_15550	COG0720	synthase
APT56_15560	COG1289	transmembrane transporter activity
APT56_15570	COG1566	PFAM secretion protein HlyD family protein
APT56_15585	COG0028	Belongs to the TPP enzyme family
APT56_15595	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_15605	COG0400	carboxylic ester hydrolase activity
APT56_15610	COG0833	amino acid
APT56_15630	COG0587	DNA-directed DNA polymerase activity
APT56_15640	COG0789	Transcriptional regulator
APT56_15650	COG0667	Aldo Keto reductase
APT56_15660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APT56_15685	COG0765	amino acid transport
APT56_15690	COG0765	amino acid transport
APT56_15695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_15705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APT56_15730	COG1309	transcriptional regulator
APT56_15735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT56_15740	COG3038	cytochrome b561
APT56_15770	COG0840	transmembrane signaling receptor activity
APT56_15845	COG2764	glyoxalase bleomycin resistance protein dioxygenase
APT56_15860	COG1414	Transcriptional regulator
APT56_15870	COG0477	Major facilitator Superfamily
APT56_15875	COG0667	Aldo Keto reductase
APT56_15885	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_15890	COG1309	transcriptional regulator
APT56_15910	COG1683	Conserved Protein
APT56_15940	COG3047	cAMP biosynthetic process
APT56_15940	COG2885	chlorophyll binding
APT56_15945	COG3795	YCII-related domain
APT56_15950	COG3795	YCII-related domain
APT56_15960	COG4941	Belongs to the sigma-70 factor family
APT56_15970	COG0697	spore germination
APT56_15980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT56_15990	COG0583	DNA-binding transcription factor activity
APT56_16000	COG0456	acetyltransferase
APT56_16020	COG1846	Transcriptional regulator
APT56_16025	COG3541	Predicted nucleotidyltransferase
APT56_16045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_16075	COG2885	chlorophyll binding
APT56_16085	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
APT56_16105	COG3501	Rhs element vgr protein
APT56_16255	COG0024	Methionine aminopeptidase
APT56_16265	COG0625	glutathione transferase activity
APT56_16275	COG2733	membrane
APT56_16285	COG0148	phosphopyruvate hydratase activity
APT56_16310	COG0583	DNA-binding transcription factor activity
APT56_16315	COG1024	Enoyl-CoA hydratase
APT56_16315	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_16320	COG0183	Belongs to the thiolase family
APT56_16325	COG1960	acyl-CoA dehydrogenase activity
APT56_16335	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_16345	COG2515	1-aminocyclopropane-1-carboxylate deaminase
APT56_16360	COG0583	DNA-binding transcription factor activity
APT56_16370	COG1846	Transcriptional regulator
APT56_16375	COG0477	Major facilitator Superfamily
APT56_16380	COG2010	Cytochrome c
APT56_16380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APT56_16385	COG2080	2 iron, 2 sulfur cluster binding
APT56_16395	COG0596	Alpha beta hydrolase
APT56_16400	COG2309	aminopeptidase activity
APT56_16405	COG1335	isochorismatase
APT56_16410	COG2010	Cytochrome c
APT56_16410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APT56_16430	COG1522	sequence-specific DNA binding
APT56_16435	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_16440	COG3842	ATPase activity
APT56_16445	COG1840	ABC-type Fe3 transport system, periplasmic component
APT56_16450	COG4149	molybdate abc transporter
APT56_16455	COG5001	Diguanylate cyclase
APT56_16455	COG4251	negative regulation of phosphorylation
APT56_16455	COG3706	GGDEF domain
APT56_16455	COG2203	Gaf domain
APT56_16485	COG0840	transmembrane signaling receptor activity
APT56_16490	COG0154	amidase activity
APT56_16500	COG0583	DNA-binding transcription factor activity
APT56_16515	COG1199	ATP-dependent helicase activity
APT56_16530	COG0456	acetyltransferase
APT56_16565	COG0477	Major facilitator Superfamily
APT56_16590	COG0583	DNA-binding transcription factor activity
APT56_16630	COG2267	carboxylic ester hydrolase activity
APT56_16650	COG2207	Transcriptional regulator
APT56_16670	COG1335	isochorismatase
APT56_16675	COG0583	DNA-binding transcription factor activity
APT56_16680	COG0640	Transcriptional regulator
APT56_16715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APT56_16715	COG0519	Catalyzes the synthesis of GMP from XMP
APT56_16745	COG0583	DNA-binding transcription factor activity
APT56_16755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT56_16780	COG0583	DNA-binding transcription factor activity
APT56_16785	COG3048	D-serine ammonia-lyase activity
APT56_16790	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_16820	COG2072	flavoprotein involved in K transport
APT56_16825	COG0601	transmembrane transport
APT56_16830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_16840	COG4608	Belongs to the ABC transporter superfamily
APT56_16845	COG0747	negative chemotaxis
APT56_16860	COG0583	DNA-binding transcription factor activity
APT56_16865	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_16870	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APT56_16920	COG4774	siderophore transport
APT56_16960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT56_16985	COG0583	DNA-binding transcription factor activity
APT56_17020	COG1024	Enoyl-CoA hydratase
APT56_17030	COG1960	acyl-CoA dehydrogenase activity
APT56_17040	COG0583	DNA-binding transcription factor activity
APT56_17045	COG3618	amidohydrolase
APT56_17060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT56_17090	COG4774	siderophore transport
APT56_17100	COG5001	Diguanylate cyclase
APT56_17105	COG4774	siderophore transport
APT56_17150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APT56_17160	COG1953	Uracil, thiamine, allantoin
APT56_17185	COG0784	Response regulator, receiver
APT56_17185	COG2205	protein histidine kinase activity
APT56_17185	COG2198	Histidine kinase
APT56_17185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_17215	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_17225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APT56_17240	COG0583	DNA-binding transcription factor activity
APT56_17260	COG0642	Histidine kinase
APT56_17265	COG0745	RESPONSE REGULATOR receiver
APT56_17285	COG0047	phosphoribosylformylglycinamidine synthase activity
APT56_17285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APT56_17295	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APT56_17300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT56_17310	COG0613	PHP domain protein
APT56_17330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APT56_17340	COG0583	DNA-binding transcription factor activity
APT56_17350	COG0583	DNA-binding transcription factor activity
APT56_17355	COG0477	Major facilitator Superfamily
APT56_17360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT56_17370	COG0159	tryptophan synthase activity
APT56_17390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APT56_17395	COG3093	addiction module antidote protein HigA
APT56_17420	COG2249	NAD(P)H dehydrogenase (quinone) activity
APT56_17430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APT56_17435	COG0459	protein refolding
APT56_17465	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_17470	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
APT56_17500	COG4604	ABC transporter, ATP-binding protein
APT56_17505	COG4605	iron ion homeostasis
APT56_17510	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT56_17515	COG4607	ABC-type enterochelin transport system periplasmic component
APT56_17520	COG4771	TonB-dependent receptor
APT56_17525	COG0745	RESPONSE REGULATOR receiver
APT56_17535	COG0084	hydrolase, TatD family'
APT56_17540	COG1136	(ABC) transporter
APT56_17565	COG2271	Major facilitator Superfamily
APT56_17570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APT56_17575	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_17580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APT56_17595	COG3135	benzoate transporter
APT56_17600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APT56_17605	COG1309	transcriptional regulator
APT56_17610	COG0183	Belongs to the thiolase family
APT56_17615	COG1022	Amp-dependent synthetase and ligase
APT56_17620	COG0410	ABC transporter
APT56_17645	COG1024	Enoyl-CoA hydratase
APT56_17655	COG1803	Methylglyoxal synthase
APT56_17660	COG2975	iron-sulfur cluster assembly
APT56_17665	COG0633	Ferredoxin
APT56_17670	COG0443	Heat shock 70 kDa protein
APT56_17675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APT56_17680	COG0316	Belongs to the HesB IscA family
APT56_17685	COG0822	iron-sulfur transferase activity
APT56_17690	COG1104	cysteine desulfurase activity
APT56_17700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APT56_17705	COG0556	nucleotide-excision repair
APT56_17715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APT56_17720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APT56_17725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APT56_17730	COG0740	serine-type endopeptidase activity
APT56_17735	COG0544	peptidyl-prolyl cis-trans isomerase activity
APT56_17740	COG0501	Belongs to the peptidase M48B family
APT56_17750	COG1278	Cold shock
APT56_17760	COG1278	Cold shock
APT56_17785	COG0251	oxidation-reduction process
APT56_17795	COG0583	DNA-binding transcription factor activity
APT56_17835	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APT56_17850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APT56_17860	COG0277	FAD linked oxidase domain protein
APT56_17870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APT56_17875	COG2271	Major facilitator Superfamily
APT56_17910	COG2171	N-acyltransferase activity
APT56_17920	COG2890	protein-(glutamine-N5) methyltransferase activity
APT56_17925	COG0488	(ABC) transporter
APT56_17940	COG4771	TonB-dependent receptor
APT56_17945	COG4771	TonB-dependent receptor
APT56_17950	COG1858	cytochrome C peroxidase
APT56_17960	COG0210	DNA helicase
APT56_17975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APT56_17975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT56_17980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APT56_17985	COG0196	riboflavin kinase activity
APT56_17990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APT56_17995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APT56_18000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APT56_18050	COG1902	pentaerythritol trinitrate reductase activity
APT56_18055	COG1126	abc transporter atp-binding protein
APT56_18060	COG0765	amino acid transport
APT56_18065	COG0765	amino acid transport
APT56_18070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_18085	COG1764	response to oxidative stress
APT56_18090	COG1914	H( )-stimulated, divalent metal cation uptake system
APT56_18100	COG1566	PFAM secretion protein HlyD family protein
APT56_18130	COG2271	Major facilitator Superfamily
APT56_18145	COG0411	ABC transporter
APT56_18155	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_18165	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APT56_18165	COG0506	proline dehydrogenase activity
APT56_18165	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APT56_18175	COG3008	intermembrane lipid transfer
APT56_18180	COG2995	paraquat-inducible protein a
APT56_18190	COG4953	penicillin-binding protein 1C
APT56_18195	COG2373	Large extracellular alpha-helical protein
APT56_18200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APT56_18205	COG1278	Cold shock
APT56_18215	COG0183	Belongs to the thiolase family
APT56_18220	COG0038	chloride channel
APT56_18230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APT56_18240	COG1570	exodeoxyribonuclease VII activity
APT56_18245	COG0811	peptide transport
APT56_18255	COG1663	tetraacyldisaccharide 4'-kinase activity
APT56_18265	COG2835	tetraacyldisaccharide 4'-kinase activity
APT56_18270	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APT56_18275	COG0563	adenylate kinase activity
APT56_18285	COG0728	peptidoglycan biosynthetic process
APT56_18295	COG0268	Binds directly to 16S ribosomal RNA
APT56_18300	COG0583	DNA-binding transcription factor activity
APT56_18305	COG0019	diaminopimelate decarboxylase activity
APT56_18315	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_18320	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APT56_18325	COG2186	Transcriptional regulator
APT56_18335	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_18345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT56_18375	COG3384	dioxygenase
APT56_18380	COG1012	belongs to the aldehyde dehydrogenase family
APT56_18395	COG3971	2-oxopent-4-enoate hydratase activity
APT56_18405	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_18410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APT56_18420	COG1562	ergosterol biosynthetic process
APT56_18430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APT56_18445	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APT56_18460	COG5564	TIM-barrel signal transduction protein
APT56_18465	COG5441	Belongs to the UPF0261 family
APT56_18490	COG0542	response to heat
APT56_18500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT56_18510	COG0477	Major facilitator Superfamily
APT56_18515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT56_18525	COG0494	nUDIX hydrolase
APT56_18530	COG0443	Heat shock 70 kDa protein
APT56_18565	COG2814	Major facilitator Superfamily
APT56_18575	COG3530	Putative quorum-sensing-regulated virulence factor
APT56_18590	COG0625	glutathione transferase activity
APT56_18620	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_18630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT56_18650	COG3386	PFAM SMP-30 Gluconolaconase
APT56_18690	COG1522	sequence-specific DNA binding
APT56_18725	COG0519	Catalyzes the synthesis of GMP from XMP
APT56_18745	COG0519	Catalyzes the synthesis of GMP from XMP
APT56_18755	COG2951	lytic endotransglycosylase activity
APT56_18765	COG0583	DNA-binding transcription factor activity
APT56_18770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APT56_18780	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_18785	COG1309	transcriptional regulator
APT56_18795	COG1473	amidohydrolase
APT56_18800	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_18810	COG3153	acetyltransferase
APT56_18815	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
APT56_18830	COG3618	amidohydrolase
APT56_18835	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_18870	COG2011	ABC-type metal ion transport system permease component
APT56_18875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APT56_18880	COG1464	Belongs to the NlpA lipoprotein family
APT56_18925	COG2837	iron assimilation
APT56_18945	COG2169	Transcriptional regulator
APT56_18975	COG1272	protein, Hemolysin III
APT56_19015	COG3321	synthase
APT56_19015	COG0604	alcohol dehydrogenase
APT56_19025	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_19055	COG0183	Belongs to the thiolase family
APT56_19070	COG0842	Transport permease protein
APT56_19075	COG1131	(ABC) transporter
APT56_19085	COG2197	response regulator
APT56_19090	COG1116	anion transmembrane transporter activity
APT56_19090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT56_19095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_19100	COG1116	anion transmembrane transporter activity
APT56_19105	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
APT56_19110	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
APT56_19155	COG0811	peptide transport
APT56_19215	COG1396	sequence-specific DNA binding
APT56_19220	COG0235	Class ii aldolase
APT56_19230	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_19260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_19270	COG0837	glucose binding
APT56_19270	COG1737	Transcriptional regulator
APT56_19290	COG0583	DNA-binding transcription factor activity
APT56_19295	COG2814	Major facilitator Superfamily
APT56_19300	COG3706	GGDEF domain
APT56_19315	COG0500	methyltransferase
APT56_19330	COG1609	Transcriptional regulator
APT56_19335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT56_19340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APT56_19350	COG1850	ribulose-bisphosphate carboxylase activity
APT56_19360	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APT56_19360	COG3608	succinylglutamate desuccinylase aspartoacylase
APT56_19375	COG1064	alcohol dehydrogenase
APT56_19380	COG2207	Transcriptional regulator
APT56_19395	COG1113	amino acid transport
APT56_19410	COG1058	Belongs to the CinA family
APT56_19410	COG1546	Belongs to the CinA family
APT56_19420	COG3852	Histidine kinase
APT56_19445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT56_19455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APT56_19465	COG0477	Major facilitator Superfamily
APT56_19470	COG1595	DNA-templated transcription, initiation
APT56_19480	COG4774	siderophore transport
APT56_19490	COG4206	TonB-dependent receptor
APT56_19520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT56_19555	COG1414	Transcriptional regulator
APT56_19560	COG0179	Fumarylacetoacetate (FAA) hydrolase
APT56_19565	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_19575	COG2721	sulfolactate sulfo-lyase activity
APT56_19585	COG0765	amino acid transport
APT56_19600	COG4948	Mandelate Racemase Muconate Lactonizing
APT56_19610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APT56_19615	COG3958	Transketolase
APT56_19620	COG3959	Transketolase, thiamine diphosphate binding domain
APT56_19625	COG1802	Transcriptional regulator
APT56_19630	COG0371	Dehydrogenase
APT56_19635	COG3246	L-lysine catabolic process to acetate
APT56_19645	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_19655	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_19665	COG0410	ABC transporter
APT56_19675	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_19695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APT56_19700	COG2885	chlorophyll binding
APT56_19700	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APT56_19705	COG3384	dioxygenase
APT56_19720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APT56_19775	COG4964	Belongs to the GSP D family
APT56_19820	COG1846	Transcriptional regulator
APT56_19825	COG4172	Belongs to the ABC transporter superfamily
APT56_19830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_19850	COG0598	Magnesium transport protein CorA
APT56_19870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APT56_19880	COG0483	inositol monophosphate 1-phosphatase activity
APT56_19885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT56_19890	COG1045	serine acetyltransferase
APT56_19895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APT56_19900	COG0166	Belongs to the GPI family
APT56_19925	COG1051	belongs to the nudix hydrolase family
APT56_19945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT56_19970	COG0463	Glycosyl transferase, family 2
APT56_19975	COG0110	maltose O-acetyltransferase activity
APT56_19980	COG0297	glycogen (starch) synthase activity
APT56_19985	COG2197	response regulator
APT56_19990	COG2197	response regulator
APT56_20000	COG1309	transcriptional regulator
APT56_20005	COG1960	acyl-CoA dehydrogenase activity
APT56_20015	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_20015	COG1024	Enoyl-CoA hydratase
APT56_20025	COG1024	Enoyl-CoA hydratase
APT56_20025	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_20030	COG0183	Belongs to the thiolase family
APT56_20045	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_20055	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_20065	COG1132	(ABC) transporter
APT56_20075	COG3395	kinase activity
APT56_20080	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APT56_20090	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APT56_20095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
APT56_20110	COG1414	Transcriptional regulator
APT56_20120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT56_20145	COG0583	DNA-binding transcription factor activity
APT56_20155	COG0456	acetyltransferase
APT56_20185	COG1309	transcriptional regulator
APT56_20195	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
APT56_20205	COG0784	Response regulator, receiver
APT56_20205	COG2205	protein histidine kinase activity
APT56_20215	COG2205	protein histidine kinase activity
APT56_20215	COG0784	Response regulator, receiver
APT56_20235	COG0527	aspartate kinase activity
APT56_20240	COG0037	tRNA processing
APT56_20245	COG0825	malonyl-CoA metabolic process
APT56_20255	COG0215	cysteine-tRNA ligase activity
APT56_20265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APT56_20270	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT56_20275	COG1968	undecaprenyl-diphosphatase activity
APT56_20280	COG1253	flavin adenine dinucleotide binding
APT56_20305	COG0668	transmembrane transport
APT56_20345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT56_20350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_20390	COG3360	Dodecin
APT56_20400	COG0583	DNA-binding transcription factor activity
APT56_20405	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_20440	COG0583	DNA-binding transcription factor activity
APT56_20460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APT56_20465	COG2850	peptidyl-arginine hydroxylation
APT56_20475	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
APT56_20480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_20485	COG1994	Peptidase M50
APT56_20490	COG0009	L-threonylcarbamoyladenylate synthase
APT56_20495	COG2321	neutral zinc metallopeptidase
APT56_20550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT56_20555	COG1971	Probably functions as a manganese efflux pump
APT56_20560	COG3969	phosphoadenosine phosphosulfate
APT56_20565	COG1475	DNA binding
APT56_20570	COG0642	Histidine kinase
APT56_20575	COG0745	RESPONSE REGULATOR receiver
APT56_20590	COG3188	usher protein
APT56_20595	COG3121	Chaperone
APT56_20610	COG3300	MHYT domain
APT56_20610	COG5001	Diguanylate cyclase
APT56_20615	COG2205	protein histidine kinase activity
APT56_20615	COG0784	Response regulator, receiver
APT56_20620	COG2197	response regulator
APT56_20650	COG3121	Chaperone
APT56_20655	COG3188	usher protein
APT56_20665	COG0840	transmembrane signaling receptor activity
APT56_20700	COG0840	transmembrane signaling receptor activity
APT56_20705	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_20760	COG1917	Cupin 2, conserved barrel domain protein
APT56_20760	COG2207	Transcriptional regulator
APT56_20770	COG2084	Dehydrogenase
APT56_20780	COG0583	DNA-binding transcription factor activity
APT56_20795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APT56_20810	COG1802	Transcriptional regulator
APT56_20845	COG0745	RESPONSE REGULATOR receiver
APT56_20850	COG2205	protein histidine kinase activity
APT56_20855	COG1764	response to oxidative stress
APT56_20860	COG0583	DNA-binding transcription factor activity
APT56_20865	COG0601	transmembrane transport
APT56_20870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_20875	COG0444	Belongs to the ABC transporter superfamily
APT56_20880	COG4608	Belongs to the ABC transporter superfamily
APT56_20895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_20900	COG0586	Pfam SNARE associated Golgi protein
APT56_20905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_20910	COG0583	DNA-binding transcription factor activity
APT56_20925	COG1566	PFAM secretion protein HlyD family protein
APT56_20945	COG0438	transferase activity, transferring glycosyl groups
APT56_20950	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APT56_20975	COG1396	sequence-specific DNA binding
APT56_20980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_20985	COG0765	amino acid transport
APT56_20995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_21005	COG1012	belongs to the aldehyde dehydrogenase family
APT56_21030	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_21050	COG0348	domain, Protein
APT56_21070	COG3278	Belongs to the heme-copper respiratory oxidase family
APT56_21090	COG0156	8-amino-7-oxononanoate synthase activity
APT56_21100	COG4106	trans-aconitate 2-methyltransferase activity
APT56_21100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APT56_21105	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APT56_21105	COG4106	trans-aconitate 2-methyltransferase activity
APT56_21120	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
APT56_21135	COG0583	DNA-binding transcription factor activity
APT56_21140	COG2224	Isocitrate lyase
APT56_21145	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APT56_21145	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APT56_21150	COG1858	cytochrome C peroxidase
APT56_21155	COG0583	DNA-binding transcription factor activity
APT56_21160	COG0473	3-isopropylmalate dehydrogenase activity
APT56_21170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APT56_21175	COG0322	excinuclease ABC activity
APT56_21180	COG1472	Belongs to the glycosyl hydrolase 3 family
APT56_21185	COG0736	holo-[acyl-carrier-protein] synthase activity
APT56_21190	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APT56_21195	COG1538	Outer membrane efflux protein
APT56_21200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT56_21205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_21230	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APT56_21235	COG4149	molybdate abc transporter
APT56_21240	COG0725	ABC transporter, periplasmic molybdate-binding protein
APT56_21245	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
APT56_21265	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APT56_21275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_21290	COG4120	Belongs to the binding-protein-dependent transport system permease family
APT56_21300	COG0667	Aldo Keto reductase
APT56_21310	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_21315	COG1024	Enoyl-CoA hydratase
APT56_21325	COG1802	Transcriptional regulator
APT56_21335	COG0183	Belongs to the thiolase family
APT56_21340	COG1960	acyl-CoA dehydrogenase activity
APT56_21345	COG1960	acyl-CoA dehydrogenase activity
APT56_21350	COG0583	DNA-binding transcription factor activity
APT56_21375	COG4213	ABC transporter substrate-binding protein
APT56_21380	COG1129	ABC transporter
APT56_21385	COG4214	carbohydrate transport
APT56_21390	COG2706	6-phosphogluconolactonase activity
APT56_21395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT56_21410	COG4175	Glycine betaine
APT56_21410	COG3448	diguanylate cyclase activity
APT56_21415	COG4176	ABC-type proline glycine betaine transport system permease component
APT56_21425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APT56_21430	COG2814	Major facilitator Superfamily
APT56_21435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APT56_21440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APT56_21475	COG1686	Belongs to the peptidase S11 family
APT56_21485	COG1846	Transcriptional regulator
APT56_21490	COG2814	Major facilitator Superfamily
APT56_21495	COG0495	leucyl-tRNA aminoacylation
APT56_21510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APT56_21530	COG0154	amidase activity
APT56_21540	COG0477	Major facilitator Superfamily
APT56_21550	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_21565	COG0583	DNA-binding transcription factor activity
APT56_21615	COG0583	DNA-binding transcription factor activity
APT56_21620	COG0427	acetyl-CoA hydrolase
APT56_21625	COG0583	DNA-binding transcription factor activity
APT56_21630	COG3264	Mechanosensitive ion channel
APT56_21630	COG1511	domain protein
APT56_21690	COG3842	ATPase activity
APT56_21695	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT56_21700	COG1177	transmembrane transport
APT56_21705	COG3938	Belongs to the proline racemase family
APT56_21720	COG0517	IMP dehydrogenase activity
APT56_21750	COG0500	methyltransferase
APT56_21755	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APT56_21775	COG0667	Aldo Keto reductase
APT56_21780	COG2207	Transcriptional regulator
APT56_21790	COG1595	DNA-templated transcription, initiation
APT56_21805	COG2841	Protein conserved in bacteria
APT56_21820	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT56_21825	COG0477	Major facilitator Superfamily
APT56_21835	COG2814	Major facilitator Superfamily
APT56_21840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APT56_21875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APT56_21885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT56_21890	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APT56_21895	COG1534	Rna-binding protein
APT56_21900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APT56_21905	COG0840	transmembrane signaling receptor activity
APT56_21910	COG2233	PERMEase
APT56_21920	COG1840	ABC-type Fe3 transport system, periplasmic component
APT56_21940	COG0406	alpha-ribazole phosphatase activity
APT56_21945	COG4221	oxidoreductase activity
APT56_21955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APT56_21960	COG0505	Belongs to the CarA family
APT56_21965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APT56_21980	COG0745	RESPONSE REGULATOR receiver
APT56_21995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_22005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT56_22010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_22015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APT56_22025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APT56_22035	COG1074	ATP-dependent DNA helicase activity
APT56_22050	COG2070	2-Nitropropane dioxygenase
APT56_22070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_22075	COG1024	Enoyl-CoA hydratase
APT56_22085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT56_22090	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_22105	COG1686	Belongs to the peptidase S11 family
APT56_22125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APT56_22130	COG4974	Belongs to the 'phage' integrase family
APT56_22135	COG0583	DNA-binding transcription factor activity
APT56_22140	COG0028	Belongs to the TPP enzyme family
APT56_22170	COG2030	dehydratase
APT56_22190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APT56_22225	COG0411	ABC transporter
APT56_22235	COG0028	Belongs to the TPP enzyme family
APT56_22240	COG1126	abc transporter atp-binding protein
APT56_22245	COG0765	amino acid transport
APT56_22255	COG0010	Belongs to the arginase family
APT56_22260	COG1414	Transcriptional regulator
APT56_22265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_22280	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APT56_22285	COG1414	Transcriptional regulator
APT56_22290	COG0009	L-threonylcarbamoyladenylate synthase
APT56_22295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APT56_22300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APT56_22305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APT56_22310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APT56_22335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_22350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT56_22365	COG1301	dicarboxylic acid transport
APT56_22385	COG3454	Phosphonate metabolism
APT56_22390	COG4778	phosphonate C-P lyase system protein PhnL
APT56_22395	COG4107	phosphonate C-P lyase system protein PhnK
APT56_22400	COG3627	carbon phosphorus lyase activity
APT56_22405	COG3626	phosphonate metabolism
APT56_22410	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
APT56_22415	COG3624	Phosphonate C-P lyase system protein PhnG
APT56_22420	COG2188	Transcriptional regulator
APT56_22425	COG3454	Phosphonate metabolism
APT56_22430	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
APT56_22435	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
APT56_22440	COG0583	DNA-binding transcription factor activity
APT56_22460	COG3639	organic phosphonate transmembrane transporter activity
APT56_22465	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
APT56_22470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
APT56_22480	COG0640	Transcriptional regulator
APT56_22490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APT56_22500	COG0739	heme binding
APT56_22510	COG0521	Mo-molybdopterin cofactor biosynthetic process
APT56_22520	COG0306	phosphate transporter
APT56_22555	COG0625	glutathione transferase activity
APT56_22575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APT56_22580	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APT56_22595	COG0126	phosphoglycerate kinase activity
APT56_22600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APT56_22605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APT56_22615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APT56_22620	COG2732	(Barnase) inhibitor
APT56_22630	COG0281	malic enzyme
APT56_22630	COG0280	phosphate acetyltransferase
APT56_22640	COG0436	Aminotransferase
APT56_22645	COG0741	lytic transglycosylase activity
APT56_22650	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APT56_22665	COG4575	ribosome binding
APT56_22675	COG1116	anion transmembrane transporter activity
APT56_22685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT56_22690	COG1648	precorrin-2 dehydrogenase activity
APT56_22690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APT56_22695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APT56_22700	COG2027	D-alanyl-D-alanine carboxypeptidase
APT56_22715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT56_22725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APT56_22730	COG0343	queuine tRNA-ribosyltransferase activity
APT56_22735	COG1862	Preprotein translocase
APT56_22740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT56_22745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT56_22755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APT56_22765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APT56_22770	COG1702	phosphate starvation-inducible protein PhoH
APT56_22775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APT56_22780	COG4535	Mg2 and Co2 transporter CorC
APT56_22785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APT56_22790	COG0667	Aldo Keto reductase
APT56_22830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APT56_22835	COG0697	spore germination
APT56_22845	COG0678	peroxiredoxin activity
APT56_22855	COG0412	Dienelactone hydrolase
APT56_22865	COG0315	cyclic pyranopterin monophosphate synthase activity
APT56_22875	COG0314	molybdopterin synthase activity
APT56_22880	COG0521	Mo-molybdopterin cofactor biosynthetic process
APT56_22895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APT56_22915	COG3383	formate dehydrogenase (NAD+) activity
APT56_22920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APT56_22955	COG0583	DNA-binding transcription factor activity
APT56_22960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APT56_22975	COG2205	protein histidine kinase activity
APT56_22980	COG0745	RESPONSE REGULATOR receiver
APT56_22995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APT56_23010	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_23030	COG2828	Protein conserved in bacteria
APT56_23035	COG0583	DNA-binding transcription factor activity
APT56_23040	COG0456	acetyltransferase
APT56_23085	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_23095	COG0411	ABC transporter
APT56_23100	COG0410	ABC transporter
APT56_23110	COG4774	siderophore transport
APT56_23125	COG0671	phosphoesterase, PA-phosphatase related
APT56_23130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APT56_23140	COG1666	GTP binding
APT56_23145	COG1120	ATPase activity
APT56_23150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT56_23155	COG4558	Periplasmic binding protein
APT56_23160	COG3720	iron ion transport
APT56_23170	COG3712	iron ion homeostasis
APT56_23175	COG1595	DNA-templated transcription, initiation
APT56_23205	COG2378	regulation of single-species biofilm formation
APT56_23235	COG1113	amino acid transport
APT56_23245	COG1522	sequence-specific DNA binding
APT56_23250	COG1272	protein, Hemolysin III
APT56_23255	COG3191	aminopeptidase activity
APT56_23260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_23265	COG0765	amino acid transport
APT56_23270	COG1126	abc transporter atp-binding protein
APT56_23295	COG1999	signal sequence binding
APT56_23315	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
APT56_23325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APT56_23330	COG1845	cytochrome c oxidase, subunit III
APT56_23335	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APT56_23355	COG4772	TonB-dependent receptor
APT56_23375	COG0280	phosphate acetyltransferase
APT56_23375	COG0281	malic enzyme
APT56_23390	COG0697	spore germination
APT56_23425	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_23435	COG0583	DNA-binding transcription factor activity
APT56_23450	COG0456	acetyltransferase
APT56_23460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APT56_23470	COG3145	DNA-N1-methyladenine dioxygenase activity
APT56_23475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APT56_23490	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
APT56_23495	COG1285	pathogenesis
APT56_23500	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_23505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT56_23510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
APT56_23520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APT56_23535	COG3712	iron ion homeostasis
APT56_23550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APT56_23555	COG0330	HflC and HflK could
APT56_23580	COG2807	transmembrane transport
APT56_23585	COG2207	Transcriptional regulator
APT56_23590	COG4106	trans-aconitate 2-methyltransferase activity
APT56_23605	COG0583	DNA-binding transcription factor activity
APT56_23645	COG0477	Major facilitator Superfamily
APT56_23650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APT56_23655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APT56_23660	COG1845	cytochrome c oxidase, subunit III
APT56_23665	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APT56_23675	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_23680	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_23690	COG2814	Major facilitator Superfamily
APT56_23700	COG0625	glutathione transferase activity
APT56_23725	COG2197	response regulator
APT56_23750	COG3707	response regulator
APT56_23755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APT56_23755	COG2146	nitrite reductase [NAD(P)H] activity
APT56_23760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APT56_23760	COG2146	nitrite reductase [NAD(P)H] activity
APT56_23765	COG0243	molybdopterin cofactor binding
APT56_23770	COG0667	Aldo Keto reductase
APT56_23775	COG0656	L-ascorbic acid biosynthetic process
APT56_23780	COG0583	DNA-binding transcription factor activity
APT56_23785	COG0023	Translation Initiation Factor
APT56_23815	COG0840	transmembrane signaling receptor activity
APT56_23820	COG2203	Gaf domain
APT56_23820	COG2199	diguanylate cyclase activity
APT56_23825	COG0640	Transcriptional regulator
APT56_23835	COG0740	serine-type endopeptidase activity
APT56_23860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_23870	COG0596	Alpha beta hydrolase
APT56_23915	COG0028	Belongs to the TPP enzyme family
APT56_23935	COG1230	cation diffusion facilitator family transporter
APT56_23965	COG1201	RNA secondary structure unwinding
APT56_23970	COG1793	dna ligase
APT56_23985	COG0798	PFAM Bile acid sodium symporter
APT56_23990	COG1393	Belongs to the ArsC family
APT56_23995	COG0431	NADPH-dependent FMN reductase
APT56_24010	COG0697	spore germination
APT56_24045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APT56_24085	COG0745	RESPONSE REGULATOR receiver
APT56_24095	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APT56_24120	COG0793	Belongs to the peptidase S41A family
APT56_24165	COG2200	EAL domain
APT56_24190	COG4191	Histidine kinase
APT56_24205	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_24220	COG1686	Belongs to the peptidase S11 family
APT56_24260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APT56_24265	COG0459	protein refolding
APT56_24275	COG1846	Transcriptional regulator
APT56_24295	COG1917	Cupin 2, conserved barrel domain protein
APT56_24320	COG1137	ATPase activity
APT56_24325	COG0410	ABC transporter
APT56_24330	COG0246	Mannitol dehydrogenase
APT56_24335	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APT56_24340	COG1252	NADH dehydrogenase
APT56_24345	COG0284	orotidine-5'-phosphate decarboxylase activity
APT56_24350	COG1546	Belongs to the CinA family
APT56_24355	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APT56_24360	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APT56_24365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT56_24370	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APT56_24395	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
APT56_24400	COG3639	organic phosphonate transmembrane transporter activity
APT56_24405	COG3639	organic phosphonate transmembrane transporter activity
APT56_24420	COG0742	ribosomal rna small subunit methyltransferase
APT56_24425	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APT56_24430	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APT56_24435	COG3135	benzoate transporter
APT56_24450	COG2814	Major facilitator Superfamily
APT56_24475	COG0012	GTP binding
APT56_24485	COG0193	aminoacyl-tRNA hydrolase activity
APT56_24490	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APT56_24495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APT56_24505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APT56_24510	COG0840	transmembrane signaling receptor activity
APT56_24515	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
APT56_24525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APT56_24550	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
APT56_24560	COG0204	Acyl-transferase
APT56_24565	COG1368	sulfuric ester hydrolase activity
APT56_24570	COG2186	Transcriptional regulator
APT56_24575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT56_24585	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT56_24595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APT56_24605	COG2205	protein histidine kinase activity
APT56_24610	COG0745	RESPONSE REGULATOR receiver
APT56_24615	COG0277	FAD linked oxidase domain protein
APT56_24630	COG0166	Belongs to the GPI family
APT56_24635	COG0405	Gamma-glutamyltransferase
APT56_24645	COG0438	transferase activity, transferring glycosyl groups
APT56_24650	COG0438	transferase activity, transferring glycosyl groups
APT56_24660	COG0438	transferase activity, transferring glycosyl groups
APT56_24675	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APT56_24680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APT56_24685	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
APT56_24695	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
APT56_24710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_24730	COG0747	negative chemotaxis
APT56_24735	COG0601	transmembrane transport
APT56_24740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_24745	COG4172	Belongs to the ABC transporter superfamily
APT56_24750	COG0154	amidase activity
APT56_24765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APT56_24765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APT56_24770	COG0509	glycine decarboxylation via glycine cleavage system
APT56_24775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APT56_24790	COG2081	HI0933 family
APT56_24795	COG1982	Orn Lys Arg decarboxylase major
APT56_24810	COG3706	GGDEF domain
APT56_24820	COG0717	Belongs to the dCTP deaminase family
APT56_24835	COG0489	protein tyrosine kinase activity
APT56_24845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT56_24845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT56_24875	COG0745	RESPONSE REGULATOR receiver
APT56_24880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APT56_24905	COG2200	EAL domain
APT56_24915	COG3243	poly(R)-hydroxyalkanoic acid synthase
APT56_24925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_24930	COG1129	ABC transporter
APT56_24930	COG0842	Transport permease protein
APT56_24935	COG0842	Transport permease protein
APT56_24945	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_24950	COG1271	oxidase subunit
APT56_24955	COG1294	oxidase, subunit
APT56_24960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_24975	COG0410	ABC transporter
APT56_24980	COG0411	ABC transporter
APT56_25000	COG0784	Response regulator, receiver
APT56_25000	COG2205	protein histidine kinase activity
APT56_25000	COG2198	Histidine kinase
APT56_25000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_25005	COG3437	response regulator, receiver
APT56_25035	COG0583	DNA-binding transcription factor activity
APT56_25040	COG3258	Cytochrome c
APT56_25050	COG0625	glutathione transferase activity
APT56_25055	COG0477	Major facilitator Superfamily
APT56_25070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APT56_25110	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APT56_25125	COG2828	Protein conserved in bacteria
APT56_25135	COG0165	Argininosuccinate lyase
APT56_25140	COG2205	protein histidine kinase activity
APT56_25145	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_25150	COG3246	L-lysine catabolic process to acetate
APT56_25170	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APT56_25205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT56_25210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_25215	COG0583	DNA-binding transcription factor activity
APT56_25220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APT56_25235	COG1652	LysM domain
APT56_25240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APT56_25245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APT56_25260	COG0625	glutathione transferase activity
APT56_25290	COG1012	belongs to the aldehyde dehydrogenase family
APT56_25335	COG1414	Transcriptional regulator
APT56_25345	COG0800	Aldolase
APT56_25350	COG4948	Mandelate Racemase Muconate Lactonizing
APT56_25355	COG2271	Major facilitator Superfamily
APT56_25360	COG1131	(ABC) transporter
APT56_25375	COG4774	siderophore transport
APT56_25380	COG2814	Major facilitator Superfamily
APT56_25390	COG1396	sequence-specific DNA binding
APT56_25395	COG0326	Molecular chaperone. Has ATPase activity
APT56_25405	COG2233	PERMEase
APT56_25430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APT56_25480	COG3657	addiction module killer protein
APT56_25495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_25500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT56_25515	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT56_25520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APT56_25530	COG3246	L-lysine catabolic process to acetate
APT56_25540	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_25545	COG0583	DNA-binding transcription factor activity
APT56_25650	COG0745	RESPONSE REGULATOR receiver
APT56_25675	COG0583	DNA-binding transcription factor activity
APT56_25685	COG1695	Transcriptional regulator
APT56_25700	COG0477	Major facilitator Superfamily
APT56_25715	COG0277	FAD linked oxidase domain protein
APT56_25725	COG3842	ATPase activity
APT56_25730	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT56_25750	COG0628	permease
APT56_25755	COG0583	DNA-binding transcription factor activity
APT56_25760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_25810	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
APT56_25820	COG2186	Transcriptional regulator
APT56_25830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APT56_25840	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_25850	COG0411	ABC transporter
APT56_25855	COG0410	ABC transporter
APT56_25860	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_25865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APT56_25875	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT56_25880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT56_25885	COG0583	DNA-binding transcription factor activity
APT56_25890	COG0129	dihydroxy-acid dehydratase activity
APT56_25900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT56_25905	COG0583	DNA-binding transcription factor activity
APT56_25925	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APT56_25930	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APT56_25935	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_25940	COG2031	fatty acid transporter
APT56_25945	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_25950	COG1414	Transcriptional regulator
APT56_25960	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APT56_25975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT56_25995	COG0288	reversible hydration of carbon dioxide
APT56_26000	COG1802	Transcriptional regulator
APT56_26005	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_26015	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_26035	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_26050	COG0625	glutathione transferase activity
APT56_26065	COG0583	DNA-binding transcription factor activity
APT56_26075	COG0583	DNA-binding transcription factor activity
APT56_26080	COG0477	Major facilitator Superfamily
APT56_26105	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_26125	COG1464	Belongs to the NlpA lipoprotein family
APT56_26140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APT56_26145	COG2890	protein-(glutamine-N5) methyltransferase activity
APT56_26150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APT56_26155	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
APT56_26165	COG1280	lysine exporter protein (LysE YggA)
APT56_26170	COG1522	sequence-specific DNA binding
APT56_26190	COG3622	Belongs to the hyi family
APT56_26205	COG0477	Major facilitator Superfamily
APT56_26215	COG2186	Transcriptional regulator
APT56_26220	COG3395	kinase activity
APT56_26225	COG2084	Dehydrogenase
APT56_26230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT56_26235	COG3622	Belongs to the hyi family
APT56_26240	COG0235	Class ii aldolase
APT56_26275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APT56_26280	COG2814	Major facilitator Superfamily
APT56_26285	COG0583	DNA-binding transcription factor activity
APT56_26295	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_26300	COG0183	Belongs to the thiolase family
APT56_26305	COG4580	involved in the transport of maltose and maltodextrins
APT56_26315	COG0142	geranyltranstransferase activity
APT56_26320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APT56_26325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APT56_26330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APT56_26335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APT56_26350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT56_26350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT56_26355	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APT56_26365	COG2186	Transcriptional regulator
APT56_26370	COG3447	MASE1 domain protein
APT56_26370	COG5001	Diguanylate cyclase
APT56_26370	COG5002	protein histidine kinase activity
APT56_26375	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APT56_26380	COG0793	Belongs to the peptidase S41A family
APT56_26385	COG4942	peptidase
APT56_26390	COG0588	phosphoglycerate mutase activity
APT56_26400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APT56_26405	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APT56_26410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APT56_26430	COG2226	methyltransferase
APT56_26435	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
APT56_26440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APT56_26445	COG0569	domain protein
APT56_26450	COG2204	response regulator
APT56_26455	COG5000	phosphorelay sensor kinase activity
APT56_26465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT56_26465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APT56_26470	COG1280	lysine exporter protein (LysE YggA)
APT56_26480	COG2076	Multidrug Resistance protein
APT56_26485	COG1733	regulation of RNA biosynthetic process
APT56_26505	COG0546	phosphoglycolate phosphatase activity
APT56_26515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APT56_26520	COG0242	peptide deformylase activity
APT56_26525	COG0758	DNA mediated transformation
APT56_26540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_26545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_26550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APT56_26555	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_26570	COG1238	metal cluster binding
APT56_26575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APT56_26580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_26595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APT56_26600	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APT56_26605	COG4988	ABC transporter
APT56_26615	COG1294	oxidase, subunit
APT56_26630	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APT56_26640	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APT56_26655	COG1137	ATPase activity
APT56_26660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APT56_26670	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APT56_26675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_26690	COG1660	Displays ATPase and GTPase activities
APT56_26700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APT56_26710	COG0792	nuclease activity
APT56_26715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APT56_26725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT56_26735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APT56_26745	COG1309	transcriptional regulator
APT56_26750	COG0471	metal ion transport
APT56_26755	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APT56_26760	COG0772	Belongs to the SEDS family
APT56_26765	COG0768	penicillin binding
APT56_26775	COG1792	Involved in formation and maintenance of cell shape
APT56_26780	COG1077	Cell shape determining protein MreB Mrl
APT56_26785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APT56_26790	COG0154	amidase activity
APT56_26795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APT56_26805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APT56_26810	COG0708	Exodeoxyribonuclease III
APT56_26815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APT56_26825	COG0583	DNA-binding transcription factor activity
APT56_26840	COG0583	DNA-binding transcription factor activity
APT56_26855	COG0411	ABC transporter
APT56_26865	COG1764	response to oxidative stress
APT56_26870	COG1846	Transcriptional regulator
APT56_26930	COG0640	Transcriptional regulator
APT56_26955	COG0297	glycogen (starch) synthase activity
APT56_26960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APT56_26965	COG3189	MarR family transcriptional regulator
APT56_26985	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_26990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APT56_26990	COG0351	phosphomethylpyrimidine kinase
APT56_26990	COG0352	thiamine-phosphate diphosphorylase activity
APT56_27015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APT56_27020	COG0513	Belongs to the DEAD box helicase family
APT56_27030	COG0617	tRNA 3'-terminal CCA addition
APT56_27040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APT56_27045	COG2308	Evidence 4 Homologs of previously reported genes of
APT56_27055	COG1305	Transglutaminase-like
APT56_27075	COG1950	PFAM Membrane protein of
APT56_27080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APT56_27085	COG0438	transferase activity, transferring glycosyl groups
APT56_27100	COG0066	3-isopropylmalate dehydratase activity
APT56_27110	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_27115	COG0583	DNA-binding transcription factor activity
APT56_27120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT56_27155	COG0477	Major facilitator Superfamily
APT56_27160	COG0154	amidase activity
APT56_27165	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APT56_27175	COG1560	Kdo2-lipid A biosynthetic process
APT56_27180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APT56_27190	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APT56_27195	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APT56_27220	COG0735	belongs to the Fur family
APT56_27225	COG0523	cobalamin synthesis protein
APT56_27230	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APT56_27235	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APT56_27240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APT56_27250	COG2096	Adenosyltransferase
APT56_27255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APT56_27260	COG1609	Transcriptional regulator
APT56_27270	COG0321	lipoyl(octanoyl) transferase activity
APT56_27275	COG2921	Belongs to the UPF0250 family
APT56_27285	COG1686	Belongs to the peptidase S11 family
APT56_27310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APT56_27320	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APT56_27330	COG0859	PFAM glycosyl transferase family 9
APT56_27340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APT56_27375	COG0438	transferase activity, transferring glycosyl groups
APT56_27385	COG2076	Multidrug Resistance protein
APT56_27400	COG2814	Major facilitator Superfamily
APT56_27430	COG3568	Endonuclease Exonuclease Phosphatase
APT56_27435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APT56_27460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APT56_27475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_27480	COG1956	GAF domain-containing protein
APT56_27485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_27495	COG1422	Protein of unknown function (DUF1090)
APT56_27510	COG2186	Transcriptional regulator
APT56_27515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APT56_27545	COG2226	methyltransferase
APT56_27550	COG0629	single-stranded DNA binding
APT56_27555	COG2814	Major facilitator Superfamily
APT56_27565	COG0625	glutathione transferase activity
APT56_27570	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APT56_27575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APT56_27580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APT56_27600	COG1965	Belongs to the frataxin family
APT56_27610	COG0019	diaminopimelate decarboxylase activity
APT56_27620	COG1333	cytochrome c biogenesis protein
APT56_27630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APT56_27645	COG4232	protein-disulfide reductase activity
APT56_27650	COG1324	tolerance protein
APT56_27660	COG0203	ribosomal protein L17
APT56_27665	COG0202	RNA polymerase activity
APT56_27670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APT56_27675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APT56_27680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APT56_27685	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APT56_27690	COG0201	protein transport
APT56_27695	COG0200	Binds to the 23S rRNA
APT56_27700	COG1841	ribosomal large subunit assembly
APT56_27705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APT56_27710	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APT56_27715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APT56_27720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APT56_27725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APT56_27730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APT56_27735	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APT56_27740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APT56_27760	COG2207	Transcriptional regulator
APT56_27765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT56_27775	COG0411	ABC transporter
APT56_27780	COG0410	ABC transporter
APT56_27800	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APT56_27805	COG0255	Belongs to the universal ribosomal protein uL29 family
APT56_27810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APT56_27815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APT56_27820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APT56_27825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APT56_27830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APT56_27835	COG0089	rRNA binding
APT56_27840	COG0088	Forms part of the polypeptide exit tunnel
APT56_27845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APT56_27850	COG0051	transcription antitermination factor activity, RNA binding
APT56_27855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APT56_27860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APT56_27865	COG0049	tRNA binding
APT56_27870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APT56_27875	COG0745	RESPONSE REGULATOR receiver
APT56_27890	COG5002	protein histidine kinase activity