locus-tag	class	description
E2544_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E2544_00010	COG0592	DNA-directed DNA polymerase activity
E2544_00025	COG0583	DNA-binding transcription factor activity
E2544_00050	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E2544_00070	COG0154	amidase activity
E2544_00075	COG1917	Cupin 2, conserved barrel domain protein
E2544_00100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2544_00130	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E2544_00140	COG0583	DNA-binding transcription factor activity
E2544_00150	COG0765	amino acid transport
E2544_00155	COG0765	amino acid transport
E2544_00160	COG1126	abc transporter atp-binding protein
E2544_00175	COG1254	Belongs to the acylphosphatase family
E2544_00185	COG1304	FMN binding
E2544_00200	COG0402	S-adenosylhomocysteine deaminase activity
E2544_00220	COG1744	ABC transporter substrate-binding protein PnrA-like
E2544_00225	COG0586	Pfam SNARE associated Golgi protein
E2544_00230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E2544_00245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2544_00265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E2544_00275	COG3781	membrane
E2544_00280	COG1522	sequence-specific DNA binding
E2544_00285	COG0028	Belongs to the TPP enzyme family
E2544_00290	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_00295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_00300	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E2544_00310	COG0551	DNA topoisomerase type I activity
E2544_00310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E2544_00320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2544_00325	COG2922	Belongs to the Smg family
E2544_00375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2544_00415	COG3712	iron ion homeostasis
E2544_00420	COG1595	DNA-templated transcription, initiation
E2544_00435	COG3339	Conserved Protein
E2544_00470	COG2814	Major facilitator Superfamily
E2544_00500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_00520	COG0583	DNA-binding transcription factor activity
E2544_00555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E2544_00560	COG0183	Belongs to the thiolase family
E2544_00565	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E2544_00570	COG1960	acyl-CoA dehydrogenase activity
E2544_00575	COG1473	amidohydrolase
E2544_00585	COG1742	UPF0060 membrane protein
E2544_00600	COG1280	lysine exporter protein (LysE YggA)
E2544_00605	COG0778	Nitroreductase
E2544_00625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2544_00635	COG0018	arginyl-trna synthetase
E2544_00650	COG0395	ABC-type sugar transport system, permease component
E2544_00655	COG1175	transmembrane transport
E2544_00660	COG1653	transport
E2544_00665	COG3842	ATPase activity
E2544_00670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E2544_00675	COG1609	Transcriptional regulator
E2544_00680	COG0154	amidase activity
E2544_00685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2544_00695	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E2544_00705	COG0583	DNA-binding transcription factor activity
E2544_00725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E2544_00730	COG1280	lysine exporter protein (LysE YggA)
E2544_00735	COG0513	Belongs to the DEAD box helicase family
E2544_00740	COG5339	Protein conserved in bacteria
E2544_00750	COG4172	Belongs to the ABC transporter superfamily
E2544_00755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_00760	COG0601	transmembrane transport
E2544_00765	COG0747	negative chemotaxis
E2544_00770	COG1160	GTP binding
E2544_00780	COG3708	Transcriptional regulator
E2544_00780	COG2207	Transcriptional regulator
E2544_00790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E2544_00800	COG0583	DNA-binding transcription factor activity
E2544_00810	COG1414	Transcriptional regulator
E2544_00815	COG0154	amidase activity
E2544_00830	COG2969	positive regulation of protein catabolic process
E2544_00835	COG0625	glutathione transferase activity
E2544_00840	COG2857	Cytochrome c1
E2544_00845	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E2544_00850	COG0723	plastoquinol--plastocyanin reductase activity
E2544_00855	COG1970	mechanosensitive ion channel activity
E2544_00860	COG0235	Class ii aldolase
E2544_00870	COG0477	Major facilitator Superfamily
E2544_00880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E2544_00885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2544_00900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2544_00905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2544_00910	COG0537	adenosine 5'-monophosphoramidase activity
E2544_00915	COG0140	phosphoribosyl-ATP diphosphatase activity
E2544_00920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E2544_00925	COG0107	imidazoleglycerol-phosphate synthase activity
E2544_00930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E2544_00935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E2544_00940	COG0131	Imidazoleglycerol-phosphate dehydratase
E2544_00945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2544_00950	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E2544_00955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E2544_00960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E2544_00970	COG0842	Transport permease protein
E2544_00975	COG1131	(ABC) transporter
E2544_00985	COG2853	Lipoprotein
E2544_00990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E2544_00995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E2544_01000	COG1127	ABC transporter
E2544_01015	COG0477	Major facilitator Superfamily
E2544_01020	COG0583	DNA-binding transcription factor activity
E2544_01035	COG0067	glutamate synthase
E2544_01035	COG0069	glutamate synthase activity
E2544_01035	COG0070	glutamate synthase
E2544_01060	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E2544_01080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2544_01110	COG1612	heme a metabolic process
E2544_01115	COG0109	protoheme IX farnesyltransferase activity
E2544_01120	COG1999	signal sequence binding
E2544_01140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E2544_01145	COG2814	Major facilitator Superfamily
E2544_01160	COG1522	sequence-specific DNA binding
E2544_01165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2544_01175	COG0457	Tetratricopeptide repeat
E2544_01180	COG0438	transferase activity, transferring glycosyl groups
E2544_01205	COG1560	Kdo2-lipid A biosynthetic process
E2544_01205	COG4783	chaperone-mediated protein folding
E2544_01210	COG3866	Pectate lyase
E2544_01220	COG3550	peptidyl-serine autophosphorylation
E2544_01230	COG2814	Major facilitator Superfamily
E2544_01245	COG3246	L-lysine catabolic process to acetate
E2544_01255	COG0861	Integral membrane protein TerC family
E2544_01295	COG1956	GAF domain-containing protein
E2544_01305	COG0656	L-ascorbic acid biosynthetic process
E2544_01315	COG2423	ornithine cyclodeaminase activity
E2544_01325	COG1522	sequence-specific DNA binding
E2544_01330	COG2423	ornithine cyclodeaminase activity
E2544_01340	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E2544_01345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E2544_01355	COG0438	transferase activity, transferring glycosyl groups
E2544_01360	COG0737	Belongs to the 5'-nucleotidase family
E2544_01390	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E2544_01405	COG2814	Major facilitator Superfamily
E2544_01410	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_01415	COG0583	DNA-binding transcription factor activity
E2544_01420	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_01425	COG1473	amidohydrolase
E2544_01430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E2544_01480	COG1802	Transcriptional regulator
E2544_01490	COG3069	C4-dicarboxylate transmembrane transporter activity
E2544_01505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2544_01505	COG0543	2 iron, 2 sulfur cluster binding
E2544_01515	COG0431	NADPH-dependent FMN reductase
E2544_01520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_01530	COG3585	molybdate ion transport
E2544_01535	COG3064	Membrane
E2544_01560	COG1607	acyl-coa hydrolase
E2544_01570	COG0243	molybdopterin cofactor binding
E2544_01570	COG3383	formate dehydrogenase (NAD+) activity
E2544_01575	COG3383	formate dehydrogenase (NAD+) activity
E2544_01575	COG0243	molybdopterin cofactor binding
E2544_01580	COG0437	4 iron, 4 sulfur cluster binding
E2544_01585	COG2864	formate dehydrogenase
E2544_01600	COG3276	selenocysteine insertion sequence binding
E2544_01615	COG1305	Transglutaminase-like
E2544_01620	COG0709	Synthesizes selenophosphate from selenide and ATP
E2544_01645	COG1012	belongs to the aldehyde dehydrogenase family
E2544_01650	COG3284	Transcriptional regulator
E2544_01655	COG0134	indole-3-glycerol-phosphate synthase activity
E2544_01660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E2544_01665	COG0512	Glutamine amidotransferase of anthranilate synthase
E2544_01675	COG0546	phosphoglycolate phosphatase activity
E2544_01685	COG2967	ApaG domain
E2544_01690	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E2544_01695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_01700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2544_01705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_01710	COG0037	tRNA processing
E2544_01735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2544_01745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2544_01750	COG0583	DNA-binding transcription factor activity
E2544_01755	COG0683	leucine binding
E2544_01760	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_01765	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_01780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2544_01805	COG3473	Maleate cis-trans isomerase
E2544_01820	COG1024	Enoyl-CoA hydratase
E2544_01835	COG0356	it plays a direct role in the translocation of protons across the membrane
E2544_01845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E2544_01850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E2544_01855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E2544_01860	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E2544_01865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E2544_01870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E2544_01880	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E2544_01885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E2544_01890	COG0210	DNA helicase
E2544_01895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2544_01905	COG2171	N-acyltransferase activity
E2544_01920	COG2195	Cleaves the N-terminal amino acid of tripeptides
E2544_01930	COG4608	Belongs to the ABC transporter superfamily
E2544_01935	COG0444	Belongs to the ABC transporter superfamily
E2544_01945	COG0601	transmembrane transport
E2544_01950	COG4166	transmembrane transport
E2544_01955	COG2988	succinylglutamate desuccinylase activity
E2544_01960	COG0583	DNA-binding transcription factor activity
E2544_01965	COG0747	negative chemotaxis
E2544_01975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E2544_01980	COG1024	Enoyl-CoA hydratase
E2544_01985	COG1024	Enoyl-CoA hydratase
E2544_01995	COG1309	transcriptional regulator
E2544_02005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_02010	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_02020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2544_02025	COG0523	cobalamin synthesis protein
E2544_02040	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_02055	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_02070	COG0784	Response regulator, receiver
E2544_02070	COG2205	protein histidine kinase activity
E2544_02075	COG2197	response regulator
E2544_02115	COG1764	response to oxidative stress
E2544_02120	COG0583	DNA-binding transcription factor activity
E2544_02130	COG1595	DNA-templated transcription, initiation
E2544_02140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2544_02190	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2544_02200	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_02210	COG0411	ABC transporter
E2544_02220	COG1802	Transcriptional regulator
E2544_02230	COG0583	DNA-binding transcription factor activity
E2544_02250	COG2918	glutathione biosynthetic process
E2544_02275	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E2544_02280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_02290	COG2721	sulfolactate sulfo-lyase activity
E2544_02295	COG2721	sulfolactate sulfo-lyase activity
E2544_02300	COG2188	Transcriptional regulator
E2544_02305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2544_02310	COG2813	Specifically methylates the guanine in position
E2544_02310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2544_02315	COG2223	nitrite transmembrane transporter activity
E2544_02325	COG2860	membrane
E2544_02330	COG1802	Transcriptional regulator
E2544_02335	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E2544_02340	COG1984	allophanate hydrolase subunit 2
E2544_02345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E2544_02355	COG0583	DNA-binding transcription factor activity
E2544_02360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_02380	COG5002	protein histidine kinase activity
E2544_02385	COG0745	RESPONSE REGULATOR receiver
E2544_02390	COG2226	methyltransferase
E2544_02405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E2544_02415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E2544_02425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2544_02430	COG0351	phosphomethylpyrimidine kinase
E2544_02435	COG2022	thiamine diphosphate biosynthetic process
E2544_02440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E2544_02445	COG4771	TonB-dependent receptor
E2544_02455	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_02465	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_02495	COG0583	DNA-binding transcription factor activity
E2544_02510	COG0625	glutathione transferase activity
E2544_02520	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_02525	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_02530	COG0410	ABC transporter
E2544_02545	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_02555	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_02560	COG1802	Transcriptional regulator
E2544_02565	COG0288	reversible hydration of carbon dioxide
E2544_02585	COG2226	methyltransferase
E2544_02595	COG1802	Transcriptional regulator
E2544_02600	COG0028	Belongs to the TPP enzyme family
E2544_02615	COG1194	a g-specific adenine glycosylase
E2544_02625	COG0583	DNA-binding transcription factor activity
E2544_02630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2544_02635	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2544_02645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E2544_02650	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_02660	COG0411	ABC transporter
E2544_02670	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_02680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E2544_02690	COG2186	Transcriptional regulator
E2544_02700	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
E2544_02710	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E2544_02715	COG2177	Part of the ABC transporter FtsEX involved in
E2544_02720	COG2884	Cell division ATP-binding protein ftsE
E2544_02725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_02730	COG4597	amino acid ABC transporter
E2544_02735	COG0765	amino acid transport
E2544_02740	COG1126	abc transporter atp-binding protein
E2544_02760	COG1129	ABC transporter
E2544_02765	COG4177	L-phenylalanine transmembrane transporter activity
E2544_02770	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_02780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_02785	COG2081	HI0933 family
E2544_02790	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_02795	COG0077	Prephenate dehydratase
E2544_02795	COG1605	Chorismate mutase
E2544_02800	COG0625	glutathione transferase activity
E2544_02835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_02840	COG0583	DNA-binding transcription factor activity
E2544_02845	COG0628	permease
E2544_02855	COG0477	Major facilitator Superfamily
E2544_02870	COG1695	Transcriptional regulator
E2544_02880	COG0583	DNA-binding transcription factor activity
E2544_02925	COG0583	DNA-binding transcription factor activity
E2544_02930	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_02940	COG3246	L-lysine catabolic process to acetate
E2544_02945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E2544_02950	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2544_02965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_02975	COG0583	DNA-binding transcription factor activity
E2544_02980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2544_03000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_03005	COG2010	Cytochrome c
E2544_03005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E2544_03010	COG1335	isochorismatase
E2544_03015	COG2309	aminopeptidase activity
E2544_03020	COG0596	Alpha beta hydrolase
E2544_03030	COG2080	2 iron, 2 sulfur cluster binding
E2544_03035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E2544_03035	COG2010	Cytochrome c
E2544_03040	COG0477	Major facilitator Superfamily
E2544_03045	COG1846	Transcriptional regulator
E2544_03075	COG4221	oxidoreductase activity
E2544_03160	COG2233	PERMEase
E2544_03170	COG0326	Molecular chaperone. Has ATPase activity
E2544_03180	COG0604	alcohol dehydrogenase
E2544_03210	COG2814	Major facilitator Superfamily
E2544_03220	COG1473	amidohydrolase
E2544_03225	COG2271	Major facilitator Superfamily
E2544_03230	COG4948	Mandelate Racemase Muconate Lactonizing
E2544_03235	COG0800	Aldolase
E2544_03240	COG3734	2-keto-3-deoxy-galactonokinase
E2544_03245	COG1414	Transcriptional regulator
E2544_03250	COG0625	glutathione transferase activity
E2544_03270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E2544_03280	COG1652	LysM domain
E2544_03300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E2544_03310	COG1295	ribonuclease BN
E2544_03320	COG2124	cytochrome p450
E2544_03350	COG0459	protein refolding
E2544_03355	COG2207	Transcriptional regulator
E2544_03360	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_03395	COG2070	2-Nitropropane dioxygenase
E2544_03405	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E2544_03420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_03425	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2544_03455	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E2544_03495	COG2828	Protein conserved in bacteria
E2544_03500	COG0583	DNA-binding transcription factor activity
E2544_03510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2544_03520	COG3121	Chaperone
E2544_03525	COG1448	Aminotransferase
E2544_03530	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2544_03550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E2544_03555	COG0410	ABC transporter
E2544_03590	COG3706	GGDEF domain
E2544_03590	COG0745	RESPONSE REGULATOR receiver
E2544_03615	COG3275	phosphorelay sensor kinase activity
E2544_03620	COG1522	sequence-specific DNA binding
E2544_03635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2544_03640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_03645	COG0006	proline dipeptidase activity
E2544_03660	COG1982	Orn Lys Arg decarboxylase major
E2544_03690	COG0505	Belongs to the CarA family
E2544_03700	COG0477	Major facilitator Superfamily
E2544_03710	COG1802	Transcriptional regulator
E2544_03725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_03735	COG0583	DNA-binding transcription factor activity
E2544_03740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E2544_03755	COG3135	benzoate transporter
E2544_03765	COG2072	flavoprotein involved in K transport
E2544_03770	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_03775	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E2544_03795	COG0165	Argininosuccinate lyase
E2544_03810	COG2132	Multicopper oxidase
E2544_03875	COG3210	domain, Protein
E2544_03900	COG3284	Transcriptional regulator
E2544_03910	COG2267	carboxylic ester hydrolase activity
E2544_03920	COG0583	DNA-binding transcription factor activity
E2544_03925	COG0583	DNA-binding transcription factor activity
E2544_04100	COG3501	Rhs element vgr protein
E2544_04130	COG0625	glutathione transferase activity
E2544_04135	COG0583	DNA-binding transcription factor activity
E2544_04140	COG1053	succinate dehydrogenase
E2544_04140	COG3976	FMN-binding domain protein
E2544_04155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_04165	COG1294	oxidase, subunit
E2544_04170	COG1271	oxidase subunit
E2544_04175	COG0697	spore germination
E2544_04195	COG0842	Transport permease protein
E2544_04200	COG0842	Transport permease protein
E2544_04200	COG1129	ABC transporter
E2544_04205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_04220	COG2200	EAL domain
E2544_04225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E2544_04230	COG0745	RESPONSE REGULATOR receiver
E2544_04240	COG2755	lipolytic protein G-D-S-L family
E2544_04240	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E2544_04260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2544_04260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2544_04270	COG0489	protein tyrosine kinase activity
E2544_04285	COG0717	Belongs to the dCTP deaminase family
E2544_04295	COG2199	diguanylate cyclase activity
E2544_04310	COG1982	Orn Lys Arg decarboxylase major
E2544_04315	COG2081	HI0933 family
E2544_04330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E2544_04335	COG0509	glycine decarboxylation via glycine cleavage system
E2544_04340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E2544_04340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E2544_04355	COG0154	amidase activity
E2544_04360	COG4172	Belongs to the ABC transporter superfamily
E2544_04365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_04370	COG0601	transmembrane transport
E2544_04395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_04410	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E2544_04420	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E2544_04425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2544_04430	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E2544_04445	COG0438	transferase activity, transferring glycosyl groups
E2544_04455	COG0438	transferase activity, transferring glycosyl groups
E2544_04460	COG0438	transferase activity, transferring glycosyl groups
E2544_04465	COG0438	transferase activity, transferring glycosyl groups
E2544_04470	COG0166	Belongs to the GPI family
E2544_04485	COG0277	FAD linked oxidase domain protein
E2544_04490	COG0745	RESPONSE REGULATOR receiver
E2544_04495	COG0642	Histidine kinase
E2544_04505	COG2186	Transcriptional regulator
E2544_04510	COG1368	sulfuric ester hydrolase activity
E2544_04515	COG0204	Acyl-transferase
E2544_04525	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E2544_04540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_04550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E2544_04565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E2544_04575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E2544_04580	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E2544_04585	COG0193	aminoacyl-tRNA hydrolase activity
E2544_04595	COG0012	GTP binding
E2544_04605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_04610	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_04615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_04615	COG0473	3-isopropylmalate dehydrogenase activity
E2544_04630	COG2814	Major facilitator Superfamily
E2544_04645	COG3135	benzoate transporter
E2544_04650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2544_04655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E2544_04660	COG0742	ribosomal rna small subunit methyltransferase
E2544_04680	COG3639	organic phosphonate transmembrane transporter activity
E2544_04685	COG3639	organic phosphonate transmembrane transporter activity
E2544_04690	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E2544_04715	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E2544_04720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2544_04730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E2544_04735	COG1546	Belongs to the CinA family
E2544_04740	COG0284	orotidine-5'-phosphate decarboxylase activity
E2544_04745	COG1252	NADH dehydrogenase
E2544_04750	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E2544_04760	COG1063	alcohol dehydrogenase
E2544_04765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_04775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_04780	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_04790	COG2721	sulfolactate sulfo-lyase activity
E2544_04795	COG4948	Mandelate Racemase Muconate Lactonizing
E2544_04800	COG0246	Mannitol dehydrogenase
E2544_04805	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E2544_04815	COG1917	Cupin 2, conserved barrel domain protein
E2544_04835	COG1846	Transcriptional regulator
E2544_04845	COG0459	protein refolding
E2544_04850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E2544_04875	COG0583	DNA-binding transcription factor activity
E2544_04880	COG3618	amidohydrolase
E2544_04885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_04905	COG2084	Dehydrogenase
E2544_04910	COG1304	FMN binding
E2544_04920	COG0697	spore germination
E2544_04940	COG0500	methyltransferase
E2544_04950	COG0693	protein deglycase activity
E2544_04980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_05005	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_05010	COG0411	ABC transporter
E2544_05015	COG0410	ABC transporter
E2544_05035	COG3618	amidohydrolase
E2544_05040	COG0473	3-isopropylmalate dehydrogenase activity
E2544_05050	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_05055	COG1802	Transcriptional regulator
E2544_05060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E2544_05065	COG0583	DNA-binding transcription factor activity
E2544_05075	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_05080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_05090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2544_05115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_05120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_05140	COG0583	DNA-binding transcription factor activity
E2544_05180	COG1595	DNA-templated transcription, initiation
E2544_05190	COG1024	Enoyl-CoA hydratase
E2544_05210	COG0444	Belongs to the ABC transporter superfamily
E2544_05220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_05230	COG1024	Enoyl-CoA hydratase
E2544_05260	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_05265	COG1802	Transcriptional regulator
E2544_05275	COG0247	lactate metabolic process
E2544_05285	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_05295	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_05300	COG2076	Multidrug Resistance protein
E2544_05305	COG1309	transcriptional regulator
E2544_05325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_05330	COG0583	DNA-binding transcription factor activity
E2544_05335	COG1522	sequence-specific DNA binding
E2544_05340	COG0626	cystathionine gamma-synthase activity
E2544_05345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_05350	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_05405	COG3501	Rhs element vgr protein
E2544_05430	COG1301	dicarboxylic acid transport
E2544_05475	COG4774	siderophore transport
E2544_05500	COG1733	regulation of RNA biosynthetic process
E2544_05510	COG0668	transmembrane transport
E2544_05540	COG2249	NAD(P)H dehydrogenase (quinone) activity
E2544_05545	COG1802	Transcriptional regulator
E2544_05550	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2544_05555	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_05570	COG1960	acyl-CoA dehydrogenase activity
E2544_05590	COG1454	alcohol dehydrogenase
E2544_05595	COG1012	belongs to the aldehyde dehydrogenase family
E2544_05605	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_05610	COG1012	belongs to the aldehyde dehydrogenase family
E2544_05610	COG2030	dehydratase
E2544_05640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2544_05645	COG0625	glutathione transferase activity
E2544_05655	COG1846	Transcriptional regulator
E2544_05660	COG2130	NADP-dependent
E2544_05665	COG2030	dehydratase
E2544_05675	COG3246	L-lysine catabolic process to acetate
E2544_05690	COG2301	Belongs to the HpcH HpaI aldolase family
E2544_05700	COG0154	amidase activity
E2544_05705	COG4608	Belongs to the ABC transporter superfamily
E2544_05710	COG0444	Belongs to the ABC transporter superfamily
E2544_05715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_05720	COG0601	transmembrane transport
E2544_05725	COG0747	negative chemotaxis
E2544_05770	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2544_05775	COG4605	iron ion homeostasis
E2544_05780	COG4604	ABC transporter, ATP-binding protein
E2544_05785	COG4607	ABC-type enterochelin transport system periplasmic component
E2544_05790	COG4774	siderophore transport
E2544_05795	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E2544_05800	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E2544_05805	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
E2544_05830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E2544_05850	COG0133	tryptophan synthase activity
E2544_05890	COG1280	lysine exporter protein (LysE YggA)
E2544_05900	COG1024	Enoyl-CoA hydratase
E2544_05905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_05950	COG2837	iron assimilation
E2544_05965	COG0667	Aldo Keto reductase
E2544_05970	COG3795	YCII-related domain
E2544_05990	COG0519	Catalyzes the synthesis of GMP from XMP
E2544_06010	COG0625	glutathione transferase activity
E2544_06020	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2544_06030	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E2544_06035	COG1845	cytochrome c oxidase, subunit III
E2544_06040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2544_06045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E2544_06050	COG0477	Major facilitator Superfamily
E2544_06055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_06060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E2544_06095	COG0583	DNA-binding transcription factor activity
E2544_06100	COG0861	Integral membrane protein TerC family
E2544_06105	COG4106	trans-aconitate 2-methyltransferase activity
E2544_06120	COG2207	Transcriptional regulator
E2544_06125	COG2807	transmembrane transport
E2544_06140	COG0330	HflC and HflK could
E2544_06145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E2544_06155	COG1595	DNA-templated transcription, initiation
E2544_06160	COG3712	iron ion homeostasis
E2544_06180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E2544_06185	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_06190	COG1285	pathogenesis
E2544_06195	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_06210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E2544_06220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2544_06225	COG1396	sequence-specific DNA binding
E2544_06230	COG0456	acetyltransferase
E2544_06270	COG0697	spore germination
E2544_06295	COG0281	malic enzyme
E2544_06295	COG0280	phosphate acetyltransferase
E2544_06315	COG4772	TonB-dependent receptor
E2544_06330	COG1845	cytochrome c oxidase, subunit III
E2544_06335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2544_06345	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E2544_06365	COG1999	signal sequence binding
E2544_06380	COG1126	abc transporter atp-binding protein
E2544_06385	COG0765	amino acid transport
E2544_06390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_06395	COG3191	aminopeptidase activity
E2544_06400	COG1272	protein, Hemolysin III
E2544_06405	COG1522	sequence-specific DNA binding
E2544_06415	COG1113	amino acid transport
E2544_06425	COG2378	regulation of single-species biofilm formation
E2544_06455	COG1595	DNA-templated transcription, initiation
E2544_06470	COG3720	iron ion transport
E2544_06475	COG4558	Periplasmic binding protein
E2544_06480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2544_06485	COG1120	ATPase activity
E2544_06490	COG1666	GTP binding
E2544_06495	COG0583	DNA-binding transcription factor activity
E2544_06500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E2544_06505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E2544_06525	COG0671	phosphoesterase, PA-phosphatase related
E2544_06550	COG0410	ABC transporter
E2544_06555	COG0411	ABC transporter
E2544_06605	COG0456	acetyltransferase
E2544_06620	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_06625	COG0251	oxidation-reduction process
E2544_06640	COG0411	ABC transporter
E2544_06665	COG0683	leucine binding
E2544_06670	COG2188	Transcriptional regulator
E2544_06680	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_06695	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_06705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2544_06740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E2544_06745	COG0583	DNA-binding transcription factor activity
E2544_06775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E2544_06780	COG3383	formate dehydrogenase (NAD+) activity
E2544_06790	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E2544_06800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E2544_06805	COG0746	molybdenum cofactor guanylyltransferase activity
E2544_06810	COG0303	'Molybdopterin
E2544_06815	COG0521	Mo-molybdopterin cofactor biosynthetic process
E2544_06830	COG0315	cyclic pyranopterin monophosphate synthase activity
E2544_06840	COG0412	Dienelactone hydrolase
E2544_06850	COG0678	peroxiredoxin activity
E2544_06860	COG0697	spore germination
E2544_06865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E2544_06870	COG4191	Histidine kinase
E2544_06905	COG0667	Aldo Keto reductase
E2544_06910	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E2544_06915	COG4535	Mg2 and Co2 transporter CorC
E2544_06920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E2544_06925	COG1702	phosphate starvation-inducible protein PhoH
E2544_06930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E2544_06940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2544_06950	COG0740	serine-type endopeptidase activity
E2544_06960	COG0640	Transcriptional regulator
E2544_06965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2544_06970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2544_06975	COG1862	Preprotein translocase
E2544_06980	COG0343	queuine tRNA-ribosyltransferase activity
E2544_06985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E2544_07005	COG2027	D-alanyl-D-alanine carboxypeptidase
E2544_07010	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E2544_07015	COG1648	precorrin-2 dehydrogenase activity
E2544_07015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2544_07025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2544_07030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_07035	COG1116	anion transmembrane transporter activity
E2544_07040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2544_07045	COG0243	molybdopterin cofactor binding
E2544_07055	COG4575	ribosome binding
E2544_07070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E2544_07075	COG0741	lytic transglycosylase activity
E2544_07080	COG0436	Aminotransferase
E2544_07090	COG0281	malic enzyme
E2544_07090	COG0280	phosphate acetyltransferase
E2544_07100	COG2732	(Barnase) inhibitor
E2544_07105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E2544_07110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E2544_07115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2544_07120	COG0126	phosphoglycerate kinase activity
E2544_07135	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E2544_07140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E2544_07160	COG0625	glutathione transferase activity
E2544_07200	COG0306	phosphate transporter
E2544_07210	COG0521	Mo-molybdopterin cofactor biosynthetic process
E2544_07220	COG0739	heme binding
E2544_07230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E2544_07250	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E2544_07255	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E2544_07260	COG3639	organic phosphonate transmembrane transporter activity
E2544_07275	COG0405	Gamma-glutamyltransferase
E2544_07280	COG0583	DNA-binding transcription factor activity
E2544_07285	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E2544_07290	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E2544_07295	COG3454	Phosphonate metabolism
E2544_07300	COG2188	Transcriptional regulator
E2544_07305	COG3624	Phosphonate C-P lyase system protein PhnG
E2544_07315	COG3626	phosphonate metabolism
E2544_07320	COG3627	carbon phosphorus lyase activity
E2544_07325	COG4107	phosphonate C-P lyase system protein PhnK
E2544_07330	COG4778	phosphonate C-P lyase system protein PhnL
E2544_07335	COG3454	Phosphonate metabolism
E2544_07355	COG1301	dicarboxylic acid transport
E2544_07375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E2544_07380	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E2544_07385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E2544_07390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E2544_07395	COG0009	L-threonylcarbamoyladenylate synthase
E2544_07400	COG1414	Transcriptional regulator
E2544_07405	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2544_07415	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_07420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_07425	COG1414	Transcriptional regulator
E2544_07435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_07445	COG1126	abc transporter atp-binding protein
E2544_07450	COG0028	Belongs to the TPP enzyme family
E2544_07460	COG0411	ABC transporter
E2544_07495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E2544_07515	COG2030	dehydratase
E2544_07520	COG2814	Major facilitator Superfamily
E2544_07525	COG0583	DNA-binding transcription factor activity
E2544_07540	COG1960	acyl-CoA dehydrogenase activity
E2544_07545	COG0028	Belongs to the TPP enzyme family
E2544_07550	COG0583	DNA-binding transcription factor activity
E2544_07555	COG4974	Belongs to the 'phage' integrase family
E2544_07560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E2544_07565	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
E2544_07580	COG1686	Belongs to the peptidase S11 family
E2544_07605	COG1074	ATP-dependent DNA helicase activity
E2544_07615	COG3842	ATPase activity
E2544_07620	COG1840	ABC-type Fe3 transport system, periplasmic component
E2544_07625	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2544_07630	COG1177	transmembrane transport
E2544_07645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_07660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E2544_07670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E2544_07675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_07680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2544_07690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_07710	COG0583	DNA-binding transcription factor activity
E2544_07715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E2544_07720	COG0505	Belongs to the CarA family
E2544_07725	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E2544_07735	COG0406	alpha-ribazole phosphatase activity
E2544_07740	COG0583	DNA-binding transcription factor activity
E2544_07745	COG3842	ATPase activity
E2544_07755	COG1840	ABC-type Fe3 transport system, periplasmic component
E2544_07765	COG2233	PERMEase
E2544_07770	COG0840	transmembrane signaling receptor activity
E2544_07775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2544_07780	COG1534	Rna-binding protein
E2544_07785	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E2544_07790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2544_07800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E2544_07835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E2544_07850	COG1278	Cold shock
E2544_07860	COG1418	mRNA catabolic process
E2544_07865	COG1960	acyl-CoA dehydrogenase activity
E2544_07870	COG2030	dehydratase
E2544_07890	COG1024	Enoyl-CoA hydratase
E2544_07895	COG1960	acyl-CoA dehydrogenase activity
E2544_07910	COG1024	Enoyl-CoA hydratase
E2544_07930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E2544_07935	COG0022	dehydrogenase e1 component
E2544_07940	COG1024	Enoyl-CoA hydratase
E2544_07965	COG0683	leucine binding
E2544_07970	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_07975	COG0411	ABC transporter
E2544_07980	COG0410	ABC transporter
E2544_07985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2544_08015	COG1335	isochorismatase
E2544_08025	COG0583	DNA-binding transcription factor activity
E2544_08035	COG1609	Transcriptional regulator
E2544_08045	COG0251	oxidation-reduction process
E2544_08075	COG2207	Transcriptional regulator
E2544_08080	COG0667	Aldo Keto reductase
E2544_08090	COG0500	methyltransferase
E2544_08095	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_08100	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_08100	COG3321	synthase
E2544_08100	COG0604	alcohol dehydrogenase
E2544_08115	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_08125	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_08135	COG3246	L-lysine catabolic process to acetate
E2544_08140	COG0371	Dehydrogenase
E2544_08145	COG1802	Transcriptional regulator
E2544_08150	COG3959	Transketolase, thiamine diphosphate binding domain
E2544_08155	COG3958	Transketolase
E2544_08160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E2544_08170	COG3938	Belongs to the proline racemase family
E2544_08175	COG1177	transmembrane transport
E2544_08180	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2544_08185	COG3842	ATPase activity
E2544_08240	COG1511	domain protein
E2544_08240	COG3264	Mechanosensitive ion channel
E2544_08245	COG0583	DNA-binding transcription factor activity
E2544_08250	COG0427	acetyl-CoA hydrolase
E2544_08255	COG0583	DNA-binding transcription factor activity
E2544_08290	COG0583	DNA-binding transcription factor activity
E2544_08305	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_08315	COG0477	Major facilitator Superfamily
E2544_08325	COG0154	amidase activity
E2544_08345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E2544_08360	COG0495	leucyl-tRNA aminoacylation
E2544_08365	COG2814	Major facilitator Superfamily
E2544_08370	COG1846	Transcriptional regulator
E2544_08380	COG1686	Belongs to the peptidase S11 family
E2544_08415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E2544_08420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E2544_08425	COG2814	Major facilitator Superfamily
E2544_08430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2544_08440	COG4176	ABC-type proline glycine betaine transport system permease component
E2544_08445	COG4175	Glycine betaine
E2544_08445	COG3448	diguanylate cyclase activity
E2544_08455	COG0583	DNA-binding transcription factor activity
E2544_08460	COG0243	molybdopterin cofactor binding
E2544_08465	COG3781	membrane
E2544_08495	COG2205	protein histidine kinase activity
E2544_08495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_08505	COG2197	response regulator
E2544_08510	COG2205	protein histidine kinase activity
E2544_08510	COG0784	Response regulator, receiver
E2544_08520	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_08530	COG0235	Class ii aldolase
E2544_08535	COG1396	sequence-specific DNA binding
E2544_08545	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E2544_08555	COG1012	belongs to the aldehyde dehydrogenase family
E2544_08575	COG0765	amino acid transport
E2544_08580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_08645	COG1278	Cold shock
E2544_08790	COG0740	serine-type endopeptidase activity
E2544_08835	COG1196	nuclear chromosome segregation
E2544_08950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_08965	COG0438	transferase activity, transferring glycosyl groups
E2544_08995	COG5265	(ABC) transporter
E2544_09005	COG0438	transferase activity, transferring glycosyl groups
E2544_09010	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_09015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E2544_09025	COG2192	nodulation
E2544_09080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2544_09100	COG0166	Belongs to the GPI family
E2544_09105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E2544_09110	COG0668	transmembrane transport
E2544_09130	COG1058	Belongs to the CinA family
E2544_09130	COG1546	Belongs to the CinA family
E2544_09145	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_09160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_09185	COG0028	Belongs to the TPP enzyme family
E2544_09205	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_09255	COG1802	Transcriptional regulator
E2544_09285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2544_09300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_09310	COG0633	Ferredoxin
E2544_09315	COG0789	Transcriptional regulator
E2544_09345	COG2204	response regulator
E2544_09350	COG0784	Response regulator, receiver
E2544_09350	COG4191	Histidine kinase
E2544_09365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E2544_09375	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_09385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_09395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_09405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2544_09430	COG2808	Putative FMN-binding domain
E2544_09440	COG0640	Transcriptional regulator
E2544_09460	COG2321	neutral zinc metallopeptidase
E2544_09465	COG0009	L-threonylcarbamoyladenylate synthase
E2544_09470	COG1994	Peptidase M50
E2544_09475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_09480	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E2544_09490	COG2850	peptidyl-arginine hydroxylation
E2544_09510	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_09515	COG0583	DNA-binding transcription factor activity
E2544_09540	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_09545	COG0583	DNA-binding transcription factor activity
E2544_09555	COG3360	Dodecin
E2544_09575	COG1802	Transcriptional regulator
E2544_09595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_09600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2544_09620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_09630	COG0235	Class ii aldolase
E2544_09660	COG0668	transmembrane transport
E2544_09690	COG1253	flavin adenine dinucleotide binding
E2544_09695	COG1968	undecaprenyl-diphosphatase activity
E2544_09700	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2544_09715	COG0215	cysteine-tRNA ligase activity
E2544_09725	COG0825	malonyl-CoA metabolic process
E2544_09730	COG0037	tRNA processing
E2544_09735	COG0527	aspartate kinase activity
E2544_09745	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E2544_09760	COG1414	Transcriptional regulator
E2544_09815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E2544_09825	COG1414	Transcriptional regulator
E2544_09835	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_09845	COG1024	Enoyl-CoA hydratase
E2544_09850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E2544_09855	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2544_09860	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_09870	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2544_09875	COG2186	Transcriptional regulator
E2544_09885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E2544_09890	COG3395	kinase activity
E2544_09900	COG4774	siderophore transport
E2544_09910	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_09920	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_09935	COG0183	Belongs to the thiolase family
E2544_09940	COG1024	Enoyl-CoA hydratase
E2544_09940	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_09950	COG1024	Enoyl-CoA hydratase
E2544_09950	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_09955	COG0183	Belongs to the thiolase family
E2544_09960	COG1960	acyl-CoA dehydrogenase activity
E2544_09965	COG1309	transcriptional regulator
E2544_09975	COG2197	response regulator
E2544_09980	COG2197	response regulator
E2544_09985	COG0297	glycogen (starch) synthase activity
E2544_09990	COG0110	maltose O-acetyltransferase activity
E2544_10000	COG0438	transferase activity, transferring glycosyl groups
E2544_10020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2544_10065	COG0166	Belongs to the GPI family
E2544_10070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2544_10075	COG1045	serine acetyltransferase
E2544_10080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E2544_10095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E2544_10115	COG0598	Magnesium transport protein CorA
E2544_10130	COG0601	transmembrane transport
E2544_10135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_10140	COG4172	Belongs to the ABC transporter superfamily
E2544_10145	COG1846	Transcriptional regulator
E2544_10190	COG4964	Belongs to the GSP D family
E2544_10250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E2544_10265	COG3384	dioxygenase
E2544_10270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E2544_10280	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_10285	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_10295	COG1802	Transcriptional regulator
E2544_10305	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_10365	COG0516	GMP reductase activity
E2544_10365	COG0517	IMP dehydrogenase activity
E2544_10370	COG0583	DNA-binding transcription factor activity
E2544_10375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_10385	COG1960	acyl-CoA dehydrogenase activity
E2544_10390	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_10400	COG0183	Belongs to the thiolase family
E2544_10425	COG1960	acyl-CoA dehydrogenase activity
E2544_10440	COG1802	Transcriptional regulator
E2544_10450	COG1024	Enoyl-CoA hydratase
E2544_10455	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_10465	COG0667	Aldo Keto reductase
E2544_10475	COG4120	Belongs to the binding-protein-dependent transport system permease family
E2544_10480	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E2544_10485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_10490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_10495	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E2544_10515	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E2544_10520	COG0725	ABC transporter, periplasmic molybdate-binding protein
E2544_10525	COG4149	molybdate abc transporter
E2544_10530	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E2544_10555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_10560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2544_10565	COG1538	Outer membrane efflux protein
E2544_10570	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E2544_10575	COG0736	holo-[acyl-carrier-protein] synthase activity
E2544_10580	COG1472	Belongs to the glycosyl hydrolase 3 family
E2544_10585	COG0322	excinuclease ABC activity
E2544_10590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E2544_10600	COG1858	cytochrome C peroxidase
E2544_10605	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E2544_10605	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E2544_10610	COG2224	Isocitrate lyase
E2544_10625	COG2301	Belongs to the HpcH HpaI aldolase family
E2544_10630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_10645	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E2544_10645	COG4106	trans-aconitate 2-methyltransferase activity
E2544_10655	COG0156	8-amino-7-oxononanoate synthase activity
E2544_10675	COG3278	Belongs to the heme-copper respiratory oxidase family
E2544_10695	COG0348	domain, Protein
E2544_10710	COG2824	Alkylphosphonate utilization operon protein PhnA
E2544_10720	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_10730	COG4948	Mandelate Racemase Muconate Lactonizing
E2544_10740	COG1131	(ABC) transporter
E2544_10745	COG0842	Transport permease protein
E2544_10760	COG0789	Transcriptional regulator
E2544_10785	COG1272	protein, Hemolysin III
E2544_10810	COG2169	Transcriptional regulator
E2544_10850	COG0251	oxidation-reduction process
E2544_10890	COG1566	PFAM secretion protein HlyD family protein
E2544_10915	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E2544_10930	COG1228	amidohydrolase
E2544_10945	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_10960	COG2814	Major facilitator Superfamily
E2544_10975	COG1464	Belongs to the NlpA lipoprotein family
E2544_10980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E2544_10985	COG2011	ABC-type metal ion transport system permease component
E2544_11000	COG2326	polyphosphate kinase activity
E2544_11010	COG0023	Translation Initiation Factor
E2544_11020	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_11040	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
E2544_11055	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_11065	COG0477	Major facilitator Superfamily
E2544_11075	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_11085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E2544_11090	COG0583	DNA-binding transcription factor activity
E2544_11105	COG2951	lytic endotransglycosylase activity
E2544_11125	COG0519	Catalyzes the synthesis of GMP from XMP
E2544_11135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_11190	COG1522	sequence-specific DNA binding
E2544_11235	COG0625	glutathione transferase activity
E2544_11240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2544_11245	COG1595	DNA-templated transcription, initiation
E2544_11260	COG3530	Putative quorum-sensing-regulated virulence factor
E2544_11290	COG0443	Heat shock 70 kDa protein
E2544_11295	COG0494	nUDIX hydrolase
E2544_11325	COG0477	Major facilitator Superfamily
E2544_11335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2544_11345	COG0542	response to heat
E2544_11355	COG0446	pyridine nucleotide-disulphide oxidoreductase
E2544_11365	COG3485	protocatechuate 3,4-dioxygenase
E2544_11370	COG1012	belongs to the aldehyde dehydrogenase family
E2544_11390	COG3119	arylsulfatase activity
E2544_11410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_11415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_11420	COG1802	Transcriptional regulator
E2544_11430	COG5441	Belongs to the UPF0261 family
E2544_11435	COG5564	TIM-barrel signal transduction protein
E2544_11450	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E2544_11465	COG1477	protein flavinylation
E2544_11490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E2544_11500	COG1562	ergosterol biosynthetic process
E2544_11510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E2544_11515	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_11525	COG1234	tRNA 3'-trailer cleavage
E2544_11535	COG0596	Alpha beta hydrolase
E2544_11545	COG3971	2-oxopent-4-enoate hydratase activity
E2544_11560	COG1012	belongs to the aldehyde dehydrogenase family
E2544_11565	COG3384	dioxygenase
E2544_11595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2544_11605	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_11615	COG2186	Transcriptional regulator
E2544_11640	COG0019	diaminopimelate decarboxylase activity
E2544_11645	COG0583	DNA-binding transcription factor activity
E2544_11650	COG0268	Binds directly to 16S ribosomal RNA
E2544_11660	COG0728	peptidoglycan biosynthetic process
E2544_11670	COG0563	adenylate kinase activity
E2544_11675	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E2544_11680	COG2835	tetraacyldisaccharide 4'-kinase activity
E2544_11685	COG1663	tetraacyldisaccharide 4'-kinase activity
E2544_11695	COG0811	peptide transport
E2544_11700	COG1570	exodeoxyribonuclease VII activity
E2544_11705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E2544_11720	COG0183	Belongs to the thiolase family
E2544_11730	COG1278	Cold shock
E2544_11735	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E2544_11740	COG2373	Large extracellular alpha-helical protein
E2544_11745	COG4953	penicillin-binding protein 1C
E2544_11750	COG0542	response to heat
E2544_11755	COG2995	paraquat-inducible protein a
E2544_11760	COG3008	intermembrane lipid transfer
E2544_11770	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E2544_11770	COG0506	proline dehydrogenase activity
E2544_11770	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E2544_11780	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_11790	COG0411	ABC transporter
E2544_11800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_11805	COG1024	Enoyl-CoA hydratase
E2544_11815	COG1802	Transcriptional regulator
E2544_11820	COG2271	Major facilitator Superfamily
E2544_11840	COG1914	H( )-stimulated, divalent metal cation uptake system
E2544_11845	COG1764	response to oxidative stress
E2544_11855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_11860	COG0765	amino acid transport
E2544_11865	COG0765	amino acid transport
E2544_11870	COG1126	abc transporter atp-binding protein
E2544_11875	COG1902	pentaerythritol trinitrate reductase activity
E2544_11890	COG0583	DNA-binding transcription factor activity
E2544_11930	COG0154	amidase activity
E2544_11975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E2544_11980	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E2544_11985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E2544_11990	COG0196	riboflavin kinase activity
E2544_11995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E2544_12000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2544_12000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2544_12015	COG0210	DNA helicase
E2544_12045	COG0488	(ABC) transporter
E2544_12050	COG2890	protein-(glutamine-N5) methyltransferase activity
E2544_12060	COG2171	N-acyltransferase activity
E2544_12090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E2544_12100	COG3038	cytochrome b561
E2544_12105	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E2544_12120	COG3008	intermembrane lipid transfer
E2544_12135	COG1309	transcriptional regulator
E2544_12150	COG0583	DNA-binding transcription factor activity
E2544_12160	COG0251	oxidation-reduction process
E2544_12185	COG1278	Cold shock
E2544_12195	COG1278	Cold shock
E2544_12205	COG0501	Belongs to the peptidase M48B family
E2544_12210	COG0544	peptidyl-prolyl cis-trans isomerase activity
E2544_12215	COG0740	serine-type endopeptidase activity
E2544_12220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E2544_12225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E2544_12230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E2544_12235	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_12240	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_12260	COG0556	nucleotide-excision repair
E2544_12265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E2544_12275	COG1104	cysteine desulfurase activity
E2544_12280	COG0822	iron-sulfur transferase activity
E2544_12290	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E2544_12295	COG0443	Heat shock 70 kDa protein
E2544_12300	COG0633	Ferredoxin
E2544_12305	COG2975	iron-sulfur cluster assembly
E2544_12310	COG1803	Methylglyoxal synthase
E2544_12315	COG0583	DNA-binding transcription factor activity
E2544_12325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_12335	COG1024	Enoyl-CoA hydratase
E2544_12360	COG0410	ABC transporter
E2544_12365	COG1022	Amp-dependent synthetase and ligase
E2544_12370	COG0183	Belongs to the thiolase family
E2544_12375	COG1309	transcriptional regulator
E2544_12385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E2544_12390	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_12400	COG2271	Major facilitator Superfamily
E2544_12405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E2544_12420	COG1136	(ABC) transporter
E2544_12435	COG0745	RESPONSE REGULATOR receiver
E2544_12440	COG4771	TonB-dependent receptor
E2544_12445	COG4607	ABC-type enterochelin transport system periplasmic component
E2544_12450	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2544_12455	COG4605	iron ion homeostasis
E2544_12460	COG4604	ABC transporter, ATP-binding protein
E2544_12465	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E2544_12475	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2544_12500	COG2146	nitrite reductase [NAD(P)H] activity
E2544_12525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_12530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_12565	COG1850	ribulose-bisphosphate carboxylase activity
E2544_12575	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_12580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_12595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_12600	COG0765	amino acid transport
E2544_12605	COG0765	amino acid transport
E2544_12610	COG1126	abc transporter atp-binding protein
E2544_12615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E2544_12630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2544_12630	COG2146	nitrite reductase [NAD(P)H] activity
E2544_12635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2544_12635	COG2146	nitrite reductase [NAD(P)H] activity
E2544_12640	COG0583	DNA-binding transcription factor activity
E2544_12650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2544_12660	COG0613	PHP domain protein
E2544_12670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_12685	COG0047	phosphoribosylformylglycinamidine synthase activity
E2544_12685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E2544_12690	COG4774	siderophore transport
E2544_12695	COG3712	iron ion homeostasis
E2544_12700	COG1595	DNA-templated transcription, initiation
E2544_12710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2544_12720	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_12810	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E2544_12840	COG0543	2 iron, 2 sulfur cluster binding
E2544_12840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2544_12850	COG0346	lactoylglutathione lyase activity
E2544_12865	COG1304	FMN binding
E2544_12895	COG4977	sequence-specific DNA binding
E2544_12900	COG1335	isochorismatase
E2544_12910	COG0129	dihydroxy-acid dehydratase activity
E2544_12920	COG2271	Major facilitator Superfamily
E2544_12925	COG0583	DNA-binding transcription factor activity
E2544_12930	COG4692	amylo-alpha-1,6-glucosidase activity
E2544_12975	COG3712	iron ion homeostasis
E2544_13065	COG0747	negative chemotaxis
E2544_13070	COG4608	Belongs to the ABC transporter superfamily
E2544_13075	COG0444	Belongs to the ABC transporter superfamily
E2544_13080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_13085	COG0601	transmembrane transport
E2544_13090	COG2072	flavoprotein involved in K transport
E2544_13100	COG4774	siderophore transport
E2544_13115	COG2885	chlorophyll binding
E2544_13115	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E2544_13150	COG2755	lipolytic protein G-D-S-L family
E2544_13150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E2544_13160	COG0519	Catalyzes the synthesis of GMP from XMP
E2544_13160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E2544_13170	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_13180	COG0702	epimerase
E2544_13205	COG0028	Belongs to the TPP enzyme family
E2544_13210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E2544_13225	COG0583	DNA-binding transcription factor activity
E2544_13255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_13270	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E2544_13280	COG4221	oxidoreductase activity
E2544_13285	COG2814	Major facilitator Superfamily
E2544_13305	COG1304	FMN binding
E2544_13375	COG0583	DNA-binding transcription factor activity
E2544_13380	COG2814	Major facilitator Superfamily
E2544_13400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2544_13405	COG1902	pentaerythritol trinitrate reductase activity
E2544_13410	COG0667	Aldo Keto reductase
E2544_13470	COG2201	protein-glutamate methylesterase activity
E2544_13475	COG4251	negative regulation of phosphorylation
E2544_13475	COG2203	Gaf domain
E2544_13475	COG5001	Diguanylate cyclase
E2544_13475	COG3706	GGDEF domain
E2544_13480	COG1522	sequence-specific DNA binding
E2544_13505	COG0583	DNA-binding transcription factor activity
E2544_13525	COG3842	ATPase activity
E2544_13535	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_13540	COG1960	acyl-CoA dehydrogenase activity
E2544_13545	COG1960	acyl-CoA dehydrogenase activity
E2544_13550	COG0183	Belongs to the thiolase family
E2544_13555	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_13555	COG1024	Enoyl-CoA hydratase
E2544_13560	COG0583	DNA-binding transcription factor activity
E2544_13570	COG2733	membrane
E2544_13580	COG0625	glutathione transferase activity
E2544_13590	COG0024	Methionine aminopeptidase
E2544_13605	COG2885	chlorophyll binding
E2544_13620	COG0583	DNA-binding transcription factor activity
E2544_13640	COG2986	histidine ammonia-lyase
E2544_13645	COG0745	RESPONSE REGULATOR receiver
E2544_13650	COG0642	Histidine kinase
E2544_13670	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E2544_13680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_13690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E2544_13695	COG1846	Transcriptional regulator
E2544_13705	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_13725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E2544_13730	COG0697	spore germination
E2544_13740	COG4941	Belongs to the sigma-70 factor family
E2544_13750	COG3795	YCII-related domain
E2544_13760	COG3795	YCII-related domain
E2544_13780	COG1360	Flagellar Motor Protein
E2544_13800	COG2207	Transcriptional regulator
E2544_13810	COG1683	Conserved Protein
E2544_13835	COG1309	transcriptional regulator
E2544_13845	COG4608	Belongs to the ABC transporter superfamily
E2544_13850	COG0444	Belongs to the ABC transporter superfamily
E2544_13855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_13860	COG0601	transmembrane transport
E2544_13870	COG1802	Transcriptional regulator
E2544_13875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E2544_13885	COG0667	Aldo Keto reductase
E2544_13900	COG1414	Transcriptional regulator
E2544_13905	COG1802	Transcriptional regulator
E2544_13915	COG1473	amidohydrolase
E2544_13925	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E2544_13970	COG3706	GGDEF domain
E2544_13980	COG2267	carboxylic ester hydrolase activity
E2544_14015	COG2271	Major facilitator Superfamily
E2544_14020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2544_14035	COG0587	DNA-directed DNA polymerase activity
E2544_14050	COG0833	amino acid
E2544_14055	COG0400	carboxylic ester hydrolase activity
E2544_14065	COG1566	PFAM secretion protein HlyD family protein
E2544_14085	COG0720	synthase
E2544_14090	COG0602	queuosine metabolic process
E2544_14105	COG0583	DNA-binding transcription factor activity
E2544_14110	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_14115	COG0154	amidase activity
E2544_14125	COG1902	pentaerythritol trinitrate reductase activity
E2544_14170	COG0842	Transport permease protein
E2544_14175	COG1131	(ABC) transporter
E2544_14185	COG1309	transcriptional regulator
E2544_14190	COG2130	NADP-dependent
E2544_14215	COG3842	ATPase activity
E2544_14220	COG3842	ATPase activity
E2544_14230	COG0395	ABC-type sugar transport system, permease component
E2544_14245	COG0583	DNA-binding transcription factor activity
E2544_14250	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_14255	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E2544_14265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2544_14275	COG2203	Gaf domain
E2544_14275	COG2199	diguanylate cyclase activity
E2544_14280	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_14285	COG3387	PFAM Glycoside hydrolase 15-related
E2544_14290	COG1960	acyl-CoA dehydrogenase activity
E2544_14320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_14325	COG0420	3'-5' exonuclease activity
E2544_14340	COG1960	acyl-CoA dehydrogenase activity
E2544_14345	COG1309	transcriptional regulator
E2544_14355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_14370	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_14375	COG2111	Na H antiporter
E2544_14375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E2544_14380	COG1006	Multisubunit Na H antiporter MnhC subunit
E2544_14385	COG0651	ATP synthesis coupled electron transport
E2544_14390	COG1863	multisubunit Na H antiporter MnhE subunit
E2544_14395	COG2212	antiporter activity
E2544_14415	COG0590	tRNA wobble adenosine to inosine editing
E2544_14420	COG1619	proteins homologs of microcin C7 resistance protein MccF
E2544_14440	COG0488	(ABC) transporter
E2544_14445	COG2814	Major facilitator Superfamily
E2544_14475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2544_14480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2544_14485	COG2252	PERMEase
E2544_14490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E2544_14495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E2544_14500	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E2544_14505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2544_14530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E2544_14535	COG0789	Transcriptional regulator
E2544_14545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E2544_14545	COG0678	peroxiredoxin activity
E2544_14555	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E2544_14560	COG0584	glycerophosphoryl diester phosphodiesterase
E2544_14570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2544_14580	COG4181	ATPase activity
E2544_14590	COG1178	ABC-type Fe3 transport system permease component
E2544_14595	COG3842	ATPase activity
E2544_14600	COG0583	DNA-binding transcription factor activity
E2544_14605	COG0560	Phosphoserine phosphatase
E2544_14610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E2544_14620	COG0583	DNA-binding transcription factor activity
E2544_14650	COG0583	DNA-binding transcription factor activity
E2544_14655	COG4336	lyase activity
E2544_14665	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_14675	COG0411	ABC transporter
E2544_14680	COG0410	ABC transporter
E2544_14685	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2544_14725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_14730	COG0765	amino acid transport
E2544_14735	COG1126	abc transporter atp-binding protein
E2544_14740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2544_14745	COG1758	RNA polymerase activity
E2544_14750	COG0194	GDP metabolic process
E2544_14755	COG3258	Cytochrome c
E2544_14760	COG2863	cytochrome
E2544_14765	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_14770	COG0791	NLP P60 protein
E2544_14775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E2544_14780	COG0833	amino acid
E2544_14785	COG1561	YicC-like family, N-terminal region
E2544_14790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E2544_14800	COG1960	acyl-CoA dehydrogenase activity
E2544_14815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E2544_14820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2544_14830	COG3852	Histidine kinase
E2544_14835	COG2204	response regulator
E2544_14840	COG0583	DNA-binding transcription factor activity
E2544_14845	COG1741	Belongs to the pirin family
E2544_14850	COG1741	Belongs to the pirin family
E2544_14855	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_14860	COG3842	ATPase activity
E2544_14870	COG1840	ABC-type Fe3 transport system, periplasmic component
E2544_14885	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_14890	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_14895	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_14900	COG1414	Transcriptional regulator
E2544_14920	COG0583	DNA-binding transcription factor activity
E2544_14930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E2544_14935	COG0583	DNA-binding transcription factor activity
E2544_14940	COG0783	Belongs to the Dps family
E2544_14955	COG0745	RESPONSE REGULATOR receiver
E2544_14960	COG2205	protein histidine kinase activity
E2544_14975	COG3842	ATPase activity
E2544_14980	COG0395	ABC-type sugar transport system, permease component
E2544_14985	COG1175	transmembrane transport
E2544_14990	COG1653	transport
E2544_15000	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E2544_15010	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_15030	COG1794	racemase activity, acting on amino acids and derivatives
E2544_15035	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E2544_15045	COG0583	DNA-binding transcription factor activity
E2544_15050	COG0625	glutathione transferase activity
E2544_15055	COG2133	pyrroloquinoline quinone binding
E2544_15065	COG0697	spore germination
E2544_15070	COG2363	Small membrane protein
E2544_15100	COG0010	Belongs to the arginase family
E2544_15105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2544_15110	COG1464	Belongs to the NlpA lipoprotein family
E2544_15115	COG0745	RESPONSE REGULATOR receiver
E2544_15115	COG3706	GGDEF domain
E2544_15130	COG1408	metallophosphoesterase
E2544_15140	COG0688	phosphatidylethanolamine metabolic process
E2544_15155	COG0583	DNA-binding transcription factor activity
E2544_15170	COG0488	(ABC) transporter
E2544_15175	COG1686	Belongs to the peptidase S11 family
E2544_15200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_15205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E2544_15210	COG2203	Gaf domain
E2544_15210	COG2200	EAL domain
E2544_15210	COG2199	diguanylate cyclase activity
E2544_15215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2544_15230	COG2814	Major facilitator Superfamily
E2544_15245	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E2544_15250	COG2204	response regulator
E2544_15255	COG2204	response regulator
E2544_15285	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_15315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2544_15325	COG1289	transmembrane transporter activity
E2544_15330	COG3300	MHYT domain
E2544_15330	COG5001	Diguanylate cyclase
E2544_15340	COG1640	4-alpha-glucanotransferase
E2544_15345	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E2544_15355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E2544_15365	COG0366	Alpha amylase catalytic
E2544_15370	COG0297	glycogen (starch) synthase activity
E2544_15375	COG0028	Belongs to the TPP enzyme family
E2544_15395	COG0392	lysyltransferase activity
E2544_15400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2544_15405	COG3568	Endonuclease Exonuclease Phosphatase
E2544_15410	COG4172	Belongs to the ABC transporter superfamily
E2544_15425	COG1253	flavin adenine dinucleotide binding
E2544_15435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E2544_15440	COG0714	Associated with various cellular activities
E2544_15475	COG3119	arylsulfatase activity
E2544_15510	COG2205	protein histidine kinase activity
E2544_15520	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E2544_15550	COG3706	GGDEF domain
E2544_15565	COG0628	permease
E2544_15575	COG1619	proteins homologs of microcin C7 resistance protein MccF
E2544_15590	COG0583	DNA-binding transcription factor activity
E2544_15640	COG1960	acyl-CoA dehydrogenase activity
E2544_15650	COG0531	amino acid
E2544_15665	COG0625	glutathione transferase activity
E2544_15680	COG1024	Enoyl-CoA hydratase
E2544_15685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_15690	COG0154	amidase activity
E2544_15700	COG2186	Transcriptional regulator
E2544_15705	COG2271	Major facilitator Superfamily
E2544_15730	COG0431	NADPH-dependent FMN reductase
E2544_15740	COG0798	PFAM Bile acid sodium symporter
E2544_15750	COG0346	lactoylglutathione lyase activity
E2544_15755	COG0640	Transcriptional regulator
E2544_15795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_15800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E2544_15880	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_15885	COG0477	Major facilitator Superfamily
E2544_15895	COG0583	DNA-binding transcription factor activity
E2544_15900	COG1335	isochorismatase
E2544_15925	COG0747	negative chemotaxis
E2544_15935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_15940	COG0444	Belongs to the ABC transporter superfamily
E2544_15945	COG4608	Belongs to the ABC transporter superfamily
E2544_15955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_15965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_15975	COG0028	Belongs to the TPP enzyme family
E2544_15985	COG1012	belongs to the aldehyde dehydrogenase family
E2544_15995	COG0235	Class ii aldolase
E2544_16005	COG0583	DNA-binding transcription factor activity
E2544_16015	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_16030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E2544_16040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E2544_16045	COG0390	transport system, permease component
E2544_16065	COG1126	abc transporter atp-binding protein
E2544_16070	COG0765	amino acid transport
E2544_16080	COG0583	DNA-binding transcription factor activity
E2544_16095	COG0765	amino acid transport
E2544_16100	COG0010	Belongs to the arginase family
E2544_16105	COG1126	abc transporter atp-binding protein
E2544_16125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_16130	COG0596	Alpha beta hydrolase
E2544_16140	COG0346	lactoylglutathione lyase activity
E2544_16155	COG0028	Belongs to the TPP enzyme family
E2544_16165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2544_16195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E2544_16200	COG0583	DNA-binding transcription factor activity
E2544_16225	COG4566	intracellular signal transduction
E2544_16245	COG0583	DNA-binding transcription factor activity
E2544_16270	COG0765	amino acid transport
E2544_16290	COG3321	synthase
E2544_16290	COG0604	alcohol dehydrogenase
E2544_16290	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_16310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_16315	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_16330	COG2084	Dehydrogenase
E2544_16340	COG1073	alpha beta
E2544_16355	COG3485	protocatechuate 3,4-dioxygenase
E2544_16365	COG2885	chlorophyll binding
E2544_16370	COG2207	Transcriptional regulator
E2544_16390	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E2544_16400	COG4251	negative regulation of phosphorylation
E2544_16400	COG3706	GGDEF domain
E2544_16400	COG2203	Gaf domain
E2544_16400	COG5001	Diguanylate cyclase
E2544_16405	COG1960	acyl-CoA dehydrogenase activity
E2544_16420	COG0583	DNA-binding transcription factor activity
E2544_16455	COG1802	Transcriptional regulator
E2544_16460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_16465	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_16475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_16515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_16520	COG4597	amino acid ABC transporter
E2544_16545	COG2197	response regulator
E2544_16550	COG3850	Histidine kinase
E2544_16555	COG1763	Mo-molybdopterin cofactor biosynthetic process
E2544_16560	COG0288	reversible hydration of carbon dioxide
E2544_16570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2544_16575	COG2181	nitrate reductase activity
E2544_16580	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E2544_16585	COG1140	nitrate reductase beta subunit
E2544_16590	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E2544_16595	COG2223	nitrite transmembrane transporter activity
E2544_16635	COG0387	Pfam Sodium calcium exchanger
E2544_16645	COG0583	DNA-binding transcription factor activity
E2544_16725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_16730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2544_16735	COG1414	Transcriptional regulator
E2544_16740	COG1309	transcriptional regulator
E2544_16755	COG1021	2,3-dihydroxybenzoate-AMP ligase
E2544_16770	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_16775	COG0583	DNA-binding transcription factor activity
E2544_16830	COG2070	2-Nitropropane dioxygenase
E2544_16840	COG3848	Pyruvate phosphate dikinase
E2544_16840	COG0574	Belongs to the PEP-utilizing enzyme family
E2544_16845	COG2205	protein histidine kinase activity
E2544_16850	COG0745	RESPONSE REGULATOR receiver
E2544_16855	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E2544_16860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E2544_16870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2544_16875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2544_16885	COG0783	Belongs to the Dps family
E2544_16895	COG2879	small protein
E2544_16900	COG1966	Carbon starvation protein
E2544_16920	COG4521	taurine ABC transporter
E2544_16925	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E2544_16930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_16955	COG1228	amidohydrolase
E2544_16970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_16975	COG0601	transmembrane transport
E2544_16995	COG1414	Transcriptional regulator
E2544_17000	COG0513	Belongs to the DEAD box helicase family
E2544_17020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_17030	COG0840	transmembrane signaling receptor activity
E2544_17040	COG2814	Major facilitator Superfamily
E2544_17045	COG0386	Belongs to the glutathione peroxidase family
E2544_17050	COG1522	sequence-specific DNA binding
E2544_17060	COG0625	glutathione transferase activity
E2544_17075	COG0095	Lipoate-protein ligase
E2544_17085	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2544_17090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E2544_17095	COG0010	Belongs to the arginase family
E2544_17100	COG1126	abc transporter atp-binding protein
E2544_17110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_17120	COG0154	amidase activity
E2544_17125	COG0410	ABC transporter
E2544_17130	COG1137	ATPase activity
E2544_17150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_17155	COG1024	Enoyl-CoA hydratase
E2544_17165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E2544_17180	COG0084	hydrolase, TatD family'
E2544_17185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E2544_17190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E2544_17195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E2544_17200	COG0354	folic acid binding
E2544_17220	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E2544_17225	COG1960	acyl-CoA dehydrogenase activity
E2544_17235	COG2867	negative regulation of translational initiation
E2544_17240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E2544_17245	COG3706	GGDEF domain
E2544_17245	COG0745	RESPONSE REGULATOR receiver
E2544_17250	COG0330	HflC and HflK could
E2544_17260	COG0519	Catalyzes the synthesis of GMP from XMP
E2544_17260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E2544_17265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E2544_17265	COG2169	Transcriptional regulator
E2544_17275	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E2544_17285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2544_17290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E2544_17295	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2544_17305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E2544_17310	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2544_17315	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E2544_17320	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2544_17325	COG0750	zinc metalloprotease
E2544_17330	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E2544_17335	COG0575	Belongs to the CDS family
E2544_17340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E2544_17345	COG0233	cytoplasmic translational termination
E2544_17350	COG0528	UMP kinase activity
E2544_17355	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E2544_17360	COG0052	Belongs to the universal ribosomal protein uS2 family
E2544_17365	COG0024	Methionine aminopeptidase
E2544_17370	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E2544_17380	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E2544_17385	COG1451	nucleotide metabolic process
E2544_17395	COG1286	toxin biosynthetic process
E2544_17405	COG0285	dihydrofolate synthase activity
E2544_17415	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_17420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_17435	COG1334	flagellar protein FlaG
E2544_17460	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2544_17470	COG1677	Flagellar hook-basal body complex protein FliE
E2544_17480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E2544_17490	COG1157	protein secretion by the type III secretion system
E2544_17505	COG1580	Controls the rotational direction of flagella during chemotaxis
E2544_17515	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E2544_17520	COG3190	flagellar
E2544_17530	COG1987	bacterial-type flagellum assembly
E2544_17540	COG0840	transmembrane signaling receptor activity
E2544_17545	COG0840	transmembrane signaling receptor activity
E2544_17555	COG0840	transmembrane signaling receptor activity
E2544_17560	COG0840	transmembrane signaling receptor activity
E2544_17570	COG1256	bacterial-type flagellum assembly
E2544_17575	COG3951	Flagellar rod assembly protein muramidase FlgJ
E2544_17575	COG1705	Flagellar rod assembly protein muramidase FlgJ
E2544_17580	COG1706	bacterial-type flagellum-dependent cell motility
E2544_17585	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E2544_17590	COG4786	Flagellar basal body rod
E2544_17595	COG4787	bacterial-type flagellum-dependent cell motility
E2544_17600	COG1749	Flagellar hook protein flgE
E2544_17605	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E2544_17610	COG1558	bacterial-type flagellum-dependent cell motility
E2544_17615	COG1815	bacterial-type flagellum-dependent cell motility
E2544_17640	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2544_17645	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2544_17655	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E2544_17660	COG0745	RESPONSE REGULATOR receiver
E2544_17665	COG2201	protein-glutamate methylesterase activity
E2544_17670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E2544_17675	COG0840	transmembrane signaling receptor activity
E2544_17680	COG0835	chemotaxis
E2544_17695	COG1360	Flagellar Motor Protein
E2544_17715	COG1191	sigma factor activity
E2544_17735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2544_17735	COG4797	methyltransferase
E2544_17755	COG4804	nuclease activity
E2544_17765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2544_17770	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2544_17785	COG4566	intracellular signal transduction
E2544_17795	COG0339	signal peptide processing
E2544_17805	COG1999	signal sequence binding
E2544_17815	COG1538	Outer membrane efflux protein
E2544_17830	COG0583	DNA-binding transcription factor activity
E2544_17835	COG1187	pseudouridine synthase activity
E2544_17855	COG0410	ABC transporter
E2544_17880	COG3161	chorismate lyase activity
E2544_17895	COG1335	isochorismatase
E2544_17910	COG0066	3-isopropylmalate dehydratase activity
E2544_17915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2544_17945	COG2188	Transcriptional regulator
E2544_17950	COG3706	GGDEF domain
E2544_17950	COG0745	RESPONSE REGULATOR receiver
E2544_17970	COG4681	YaeQ
E2544_17975	COG1280	lysine exporter protein (LysE YggA)
E2544_17980	COG4172	Belongs to the ABC transporter superfamily
E2544_17990	COG0601	transmembrane transport
E2544_17995	COG0747	negative chemotaxis
E2544_18005	COG0583	DNA-binding transcription factor activity
E2544_18105	COG0668	transmembrane transport
E2544_18110	COG0165	Argininosuccinate lyase
E2544_18115	COG1598	PFAM Uncharacterised protein family UPF0150
E2544_18120	COG0583	DNA-binding transcription factor activity
E2544_18125	COG2814	Major facilitator Superfamily
E2544_18135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_18165	COG0477	Major facilitator Superfamily
E2544_18195	COG0154	amidase activity
E2544_18200	COG0583	DNA-binding transcription factor activity
E2544_18215	COG0022	dehydrogenase e1 component
E2544_18240	COG1024	Enoyl-CoA hydratase
E2544_18245	COG2186	Transcriptional regulator
E2544_18250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_18255	COG0789	Transcriptional regulator
E2544_18280	COG0840	transmembrane signaling receptor activity
E2544_18290	COG2271	Major facilitator Superfamily
E2544_18305	COG0307	riboflavin synthase, alpha
E2544_18315	COG2186	Transcriptional regulator
E2544_18320	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_18355	COG0583	DNA-binding transcription factor activity
E2544_18370	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_18435	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_18445	COG0410	ABC transporter
E2544_18450	COG0183	Belongs to the thiolase family
E2544_18455	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_18485	COG1595	DNA-templated transcription, initiation
E2544_18490	COG3712	iron ion homeostasis
E2544_18500	COG0583	DNA-binding transcription factor activity
E2544_18520	COG0640	Transcriptional regulator
E2544_18540	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_18550	COG0411	ABC transporter
E2544_18585	COG1802	Transcriptional regulator
E2544_18590	COG5265	(ABC) transporter
E2544_18595	COG1280	lysine exporter protein (LysE YggA)
E2544_18640	COG2188	Transcriptional regulator
E2544_18655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2544_18665	COG0477	Major facilitator Superfamily
E2544_18675	COG0477	Major facilitator Superfamily
E2544_18680	COG0235	Class ii aldolase
E2544_18695	COG3685	Protein conserved in bacteria
E2544_18705	COG3546	catalase activity
E2544_18720	COG0583	DNA-binding transcription factor activity
E2544_18725	COG0477	Major facilitator Superfamily
E2544_18730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2544_18755	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_18760	COG0702	epimerase
E2544_18770	COG2610	gluconate transmembrane transporter activity
E2544_18775	COG0583	DNA-binding transcription factor activity
E2544_18780	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_18785	COG1024	Enoyl-CoA hydratase
E2544_18790	COG5001	Diguanylate cyclase
E2544_18795	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_18800	COG0129	dihydroxy-acid dehydratase activity
E2544_18815	COG2226	methyltransferase
E2544_18835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_18840	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E2544_18865	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E2544_18885	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E2544_18890	COG1335	isochorismatase
E2544_18895	COG2309	aminopeptidase activity
E2544_18900	COG0596	Alpha beta hydrolase
E2544_18925	COG0583	DNA-binding transcription factor activity
E2544_18930	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_18935	COG3246	L-lysine catabolic process to acetate
E2544_18955	COG3043	anaerobic respiration
E2544_18960	COG3005	denitrification pathway
E2544_18965	COG4133	protoheme IX ABC transporter activity
E2544_18985	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E2544_18995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2544_19085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2544_19095	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_19105	COG2084	Dehydrogenase
E2544_19110	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_19120	COG2186	Transcriptional regulator
E2544_19125	COG0154	amidase activity
E2544_19135	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_19150	COG1129	ABC transporter
E2544_19155	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E2544_19165	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E2544_19170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2544_19180	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_19185	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E2544_19200	COG0697	spore germination
E2544_19205	COG0697	spore germination
E2544_19235	COG1280	lysine exporter protein (LysE YggA)
E2544_19255	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E2544_19280	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_19285	COG1960	acyl-CoA dehydrogenase activity
E2544_19290	COG2814	Major facilitator Superfamily
E2544_19305	COG0625	glutathione transferase activity
E2544_19310	COG0583	DNA-binding transcription factor activity
E2544_19315	COG0583	DNA-binding transcription factor activity
E2544_19330	COG0506	proline dehydrogenase activity
E2544_19335	COG0697	spore germination
E2544_19340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_19345	COG1959	2 iron, 2 sulfur cluster binding
E2544_19350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2544_19350	COG1017	nitric oxide dioxygenase activity
E2544_19355	COG1610	YqeY-like protein
E2544_19400	COG0457	Tetratricopeptide repeat
E2544_19405	COG1649	PFAM Uncharacterised BCR, COG1649
E2544_19405	COG0726	polysaccharide deacetylase
E2544_19410	COG1215	transferase activity, transferring glycosyl groups
E2544_19420	COG2223	nitrite transmembrane transporter activity
E2544_19425	COG1917	Cupin 2, conserved barrel domain protein
E2544_19425	COG4977	sequence-specific DNA binding
E2544_19435	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E2544_19450	COG0656	L-ascorbic acid biosynthetic process
E2544_19455	COG5265	(ABC) transporter
E2544_19470	COG0583	DNA-binding transcription factor activity
E2544_19510	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_19550	COG1522	sequence-specific DNA binding
E2544_19575	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_19585	COG0456	acetyltransferase
E2544_19590	COG0384	phenazine biosynthesis protein PhzF
E2544_19605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2544_19610	COG0583	DNA-binding transcription factor activity
E2544_19615	COG0129	dihydroxy-acid dehydratase activity
E2544_19620	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_19625	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_19650	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E2544_19655	COG0789	Transcriptional regulator
E2544_19685	COG0776	regulation of translation
E2544_19690	COG0072	phenylalanine-tRNA ligase activity
E2544_19690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2544_19695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E2544_19700	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E2544_19705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E2544_19710	COG0606	chelatase, subunit chli
E2544_19715	COG2960	long-chain fatty acid transporting porin activity
E2544_19725	COG0347	Belongs to the P(II) protein family
E2544_19730	COG0004	ammonium transporteR
E2544_19735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E2544_19740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E2544_19750	COG0189	ligase activity
E2544_19755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E2544_19760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E2544_19770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2544_19795	COG0601	transmembrane transport
E2544_19800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_19825	COG1609	Transcriptional regulator
E2544_19830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E2544_19835	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_19840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_19845	COG0129	dihydroxy-acid dehydratase activity
E2544_19855	COG0840	transmembrane signaling receptor activity
E2544_19865	COG2203	Gaf domain
E2544_19865	COG2199	diguanylate cyclase activity
E2544_19875	COG0135	phosphoribosylanthranilate isomerase activity
E2544_19880	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E2544_19885	COG0101	tRNA pseudouridine synthase activity
E2544_19895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E2544_19900	COG0473	3-isopropylmalate dehydrogenase activity
E2544_19905	COG0066	3-isopropylmalate dehydratase activity
E2544_19910	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2544_19915	COG1538	Outer membrane efflux protein
E2544_19925	COG2274	protein secretion by the type I secretion system
E2544_19930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_19955	COG4783	chaperone-mediated protein folding
E2544_19960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E2544_19985	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E2544_19995	COG1295	ribonuclease BN
E2544_20005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E2544_20040	COG4964	Belongs to the GSP D family
E2544_20085	COG0583	DNA-binding transcription factor activity
E2544_20100	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E2544_20135	COG1783	phage Terminase large subunit
E2544_20170	COG0582	viral genome integration into host DNA
E2544_20180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E2544_20190	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E2544_20195	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E2544_20200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E2544_20205	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E2544_20210	COG0330	HflC and HflK could
E2544_20215	COG0330	HflC and HflK could
E2544_20220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E2544_20225	COG1923	regulation of RNA biosynthetic process
E2544_20230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2544_20235	COG1160	GTP binding
E2544_20240	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2544_20245	COG2976	Protein conserved in bacteria
E2544_20250	COG0124	histidyl-tRNA synthetase
E2544_20255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E2544_20265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E2544_20270	COG0105	UTP biosynthetic process
E2544_20275	COG0525	valine-tRNA ligase activity
E2544_20280	COG0336	Belongs to the RNA methyltransferase TrmD family
E2544_20285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E2544_20290	COG0228	four-way junction DNA binding
E2544_20300	COG0425	Belongs to the sulfur carrier protein TusA family
E2544_20305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2544_20355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_20365	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E2544_20370	COG2076	Multidrug Resistance protein
E2544_20375	COG3217	Mosc domain protein beta barrel domain protein
E2544_20375	COG0633	Ferredoxin
E2544_20380	COG5285	phytanoyl-CoA dioxygenase
E2544_20385	COG0662	Cupin 2, conserved barrel domain protein
E2544_20390	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E2544_20410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2544_20425	COG2311	Membrane
E2544_20445	COG0187	DNA topoisomerase II activity
E2544_20455	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E2544_20465	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E2544_20470	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E2544_20490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E2544_20500	COG3391	amine dehydrogenase activity
E2544_20530	COG1846	Transcriptional regulator
E2544_20540	COG1566	PFAM secretion protein HlyD family protein
E2544_20545	COG2814	Major facilitator Superfamily
E2544_20555	COG0473	3-isopropylmalate dehydrogenase activity
E2544_20560	COG0433	COG0433 Predicted ATPase
E2544_20565	COG0217	transcriptional regulatory protein
E2544_20570	COG0151	Belongs to the GarS family
E2544_20575	COG0408	coproporphyrinogen oxidase activity
E2544_20580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E2544_20585	COG0799	negative regulation of ribosome biogenesis
E2544_20590	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E2544_20595	COG0424	maF-like protein
E2544_20600	COG1301	dicarboxylic acid transport
E2544_20605	COG4191	Histidine kinase
E2544_20610	COG2204	response regulator
E2544_20640	COG1530	ribonuclease E activity
E2544_20645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2544_20650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_20655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_20675	COG2203	Gaf domain
E2544_20675	COG3706	GGDEF domain
E2544_20675	COG5001	Diguanylate cyclase
E2544_20675	COG4251	negative regulation of phosphorylation
E2544_20685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E2544_20685	COG0475	glutathione-regulated potassium exporter activity
E2544_20690	COG1132	(ABC) transporter
E2544_20715	COG0726	polysaccharide deacetylase
E2544_20730	COG0726	polysaccharide deacetylase
E2544_20735	COG0438	transferase activity, transferring glycosyl groups
E2544_20750	COG1643	Atp-dependent helicase
E2544_20755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E2544_20755	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E2544_20760	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E2544_20770	COG0704	Plays a role in the regulation of phosphate uptake
E2544_20775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E2544_20780	COG1960	acyl-CoA dehydrogenase activity
E2544_20800	COG2094	Belongs to the DNA glycosylase MPG family
E2544_20810	COG1177	transmembrane transport
E2544_20815	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2544_20820	COG3842	ATPase activity
E2544_20830	COG3642	lipopolysaccharide core region biosynthetic process
E2544_20840	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E2544_20845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_20860	COG4608	Belongs to the ABC transporter superfamily
E2544_20865	COG0444	Belongs to the ABC transporter superfamily
E2544_20880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_20890	COG0747	negative chemotaxis
E2544_20910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2544_20915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E2544_20935	COG3618	amidohydrolase
E2544_20940	COG0583	DNA-binding transcription factor activity
E2544_20945	COG0137	argininosuccinate synthase activity
E2544_20950	COG3158	transport of potassium into the cell
E2544_20955	COG0642	Histidine kinase
E2544_20960	COG0745	RESPONSE REGULATOR receiver
E2544_20985	COG0776	regulation of translation
E2544_20990	COG3128	pkhd-type hydroxylase
E2544_20995	COG0626	cystathionine gamma-synthase activity
E2544_21000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2544_21005	COG0557	exoribonuclease II activity
E2544_21025	COG2153	protein acetylation
E2544_21040	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E2544_21045	COG2391	methyltransferase activity
E2544_21050	COG0069	glutamate synthase activity
E2544_21055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2544_21100	COG0697	spore germination
E2544_21160	COG3909	cytochrome
E2544_21170	COG0625	glutathione transferase activity
E2544_21175	COG0730	response to heat
E2544_21180	COG0482	sulfurtransferase activity
E2544_21185	COG0583	DNA-binding transcription factor activity
E2544_21200	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E2544_21205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E2544_21210	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E2544_21215	COG0247	lactate metabolic process
E2544_21220	COG0277	FAD linked oxidase domain protein
E2544_21225	COG0277	FAD linked oxidase domain protein
E2544_21230	COG0277	FAD linked oxidase domain protein
E2544_21235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E2544_21240	COG0312	modulator of DNA gyrase
E2544_21255	COG0308	aminopeptidase N
E2544_21260	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E2544_21280	COG0436	Aminotransferase
E2544_21290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E2544_21295	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E2544_21315	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_21325	COG0411	ABC transporter
E2544_21330	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_21345	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_21355	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E2544_21375	COG0181	hydroxymethylbilane synthase activity
E2544_21380	COG0861	Integral membrane protein TerC family
E2544_21385	COG0861	Integral membrane protein TerC family
E2544_21390	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E2544_21395	COG0045	succinate-CoA ligase (ADP-forming) activity
E2544_21410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E2544_21415	COG0583	DNA-binding transcription factor activity
E2544_21420	COG2137	regulation of response to DNA damage stimulus
E2544_21425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E2544_21435	COG0642	Histidine kinase
E2544_21460	COG0540	Belongs to the ATCase OTCase family
E2544_21490	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
E2544_21510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_21545	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E2544_21555	COG0305	Participates in initiation and elongation during chromosome replication
E2544_21565	COG0359	binds to the 23S rRNA
E2544_21570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E2544_21575	COG2965	DNA replication, synthesis of RNA primer
E2544_21580	COG0360	Binds together with S18 to 16S ribosomal RNA
E2544_21585	COG3739	integral membrane protein
E2544_21590	COG1469	GTP cyclohydrolase I activity
E2544_21595	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E2544_21600	COG0142	geranyltranstransferase activity
E2544_21605	COG1722	exodeoxyribonuclease VII activity
E2544_21635	COG1840	ABC-type Fe3 transport system, periplasmic component
E2544_21640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E2544_21650	COG3842	ATPase activity
E2544_21670	COG0583	DNA-binding transcription factor activity
E2544_21685	COG0501	Belongs to the peptidase M48B family
E2544_21690	COG1760	l-serine dehydratase
E2544_21695	COG1283	sodium-dependent phosphate transmembrane transporter activity
E2544_21700	COG0412	Dienelactone hydrolase
E2544_21705	COG0428	transporter
E2544_21720	COG1473	amidohydrolase
E2544_21735	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_21740	COG2271	Major facilitator Superfamily
E2544_21755	COG0583	DNA-binding transcription factor activity
E2544_21760	COG0583	DNA-binding transcription factor activity
E2544_21775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E2544_21780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E2544_21785	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E2544_21790	COG2251	uridine kinase activity
E2544_21790	COG0195	Participates in both transcription termination and antitermination
E2544_21795	COG0779	Required for maturation of 30S ribosomal subunits
E2544_21800	COG1187	pseudouridine synthase activity
E2544_21805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E2544_21815	COG0583	DNA-binding transcription factor activity
E2544_21820	COG0523	cobalamin synthesis protein
E2544_21835	COG0745	RESPONSE REGULATOR receiver
E2544_21840	COG0642	Histidine kinase
E2544_21845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2544_21850	COG0625	glutathione transferase activity
E2544_21860	COG1047	Peptidyl-prolyl cis-trans
E2544_21865	COG2003	Belongs to the UPF0758 family
E2544_21870	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E2544_21875	COG3483	tryptophan 2,3-dioxygenase activity
E2544_21880	COG0254	rRNA binding
E2544_21900	COG2050	protein possibly involved in aromatic compounds catabolism
E2544_21905	COG1024	Enoyl-CoA hydratase
E2544_21910	COG1012	belongs to the aldehyde dehydrogenase family
E2544_21915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2544_21920	COG2151	metal-sulfur cluster biosynthetic enzyme
E2544_21925	COG3396	Phenylacetate-CoA oxygenase
E2544_21930	COG3460	Phenylacetate-CoA oxygenase
E2544_21935	COG3396	Phenylacetate-CoA oxygenase
E2544_21940	COG3327	negative regulation of DNA-templated transcription, initiation
E2544_21945	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E2544_21965	COG2204	response regulator
E2544_21970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E2544_21975	COG0501	Belongs to the peptidase M48B family
E2544_21980	COG1162	GTPase activity
E2544_21990	COG0335	large ribosomal subunit rRNA binding
E2544_22020	COG0175	sulfate reduction
E2544_22030	COG4208	sulfate ABC transporter
E2544_22035	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E2544_22040	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E2544_22045	COG0450	alkyl hydroperoxide reductase
E2544_22050	COG1960	acyl-CoA dehydrogenase activity
E2544_22060	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_22060	COG1024	Enoyl-CoA hydratase
E2544_22065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_22075	COG2985	domain, Protein
E2544_22100	COG0123	including yeast histone deacetylase and acetoin utilization protein
E2544_22105	COG2951	lytic endotransglycosylase activity
E2544_22135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2544_22140	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E2544_22145	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E2544_22165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E2544_22170	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E2544_22175	COG0287	Prephenate dehydrogenase
E2544_22185	COG1605	Chorismate mutase
E2544_22185	COG0077	Prephenate dehydratase
E2544_22190	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E2544_22205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2544_22235	COG1960	acyl-CoA dehydrogenase activity
E2544_22245	COG2030	dehydratase
E2544_22250	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_22260	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_22270	COG0045	succinate-CoA ligase (ADP-forming) activity
E2544_22275	COG1960	acyl-CoA dehydrogenase activity
E2544_22285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_22290	COG1024	Enoyl-CoA hydratase
E2544_22295	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_22300	COG0583	DNA-binding transcription factor activity
E2544_22315	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_22320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E2544_22330	COG1215	transferase activity, transferring glycosyl groups
E2544_22350	COG2951	lytic endotransglycosylase activity
E2544_22355	COG2833	Protein of unknown function (DUF455)
E2544_22370	COG1132	(ABC) transporter
E2544_22380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E2544_22380	COG0189	ligase activity
E2544_22385	COG3237	CsbD-like
E2544_22395	COG2823	Periplasmic or secreted lipoprotein
E2544_22430	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
E2544_22435	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_22440	COG3243	poly(R)-hydroxyalkanoic acid synthase
E2544_22450	COG0564	pseudouridine synthase activity
E2544_22470	COG1199	ATP-dependent helicase activity
E2544_22475	COG2183	response to ionizing radiation
E2544_22485	COG0180	Tryptophanyl-tRNA synthetase
E2544_22510	COG4774	siderophore transport
E2544_22515	COG3712	iron ion homeostasis
E2544_22520	COG1595	DNA-templated transcription, initiation
E2544_22525	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E2544_22530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2544_22535	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2544_22540	COG0567	Dehydrogenase, E1 component
E2544_22545	COG1522	sequence-specific DNA binding
E2544_22550	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E2544_22565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2544_22570	COG1297	OPT oligopeptide transporter protein
E2544_22580	COG0281	malic enzyme
E2544_22580	COG0280	phosphate acetyltransferase
E2544_22595	COG0372	Belongs to the citrate synthase family
E2544_22600	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E2544_22605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E2544_22610	COG1053	succinate dehydrogenase
E2544_22615	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E2544_22620	COG2009	succinate dehydrogenase
E2544_22625	COG2188	Transcriptional regulator
E2544_22630	COG0039	L-malate dehydrogenase activity
E2544_22680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2544_22690	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E2544_22705	COG0148	phosphopyruvate hydratase activity
E2544_22720	COG0504	CTP synthase activity
E2544_22745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_22755	COG0747	negative chemotaxis
E2544_22760	COG4172	Belongs to the ABC transporter superfamily
E2544_22765	COG1446	asparaginase
E2544_22775	COG2153	protein acetylation
E2544_22800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2544_22830	COG0747	negative chemotaxis
E2544_22850	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E2544_22855	COG0697	spore germination
E2544_22870	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E2544_22875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2544_22880	COG0791	NLP P60 protein
E2544_22890	COG0583	DNA-binding transcription factor activity
E2544_22915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E2544_22945	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_22955	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E2544_22965	COG1381	Involved in DNA repair and RecF pathway recombination
E2544_22970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E2544_22975	COG0571	ribonuclease III activity
E2544_22980	COG0681	Belongs to the peptidase S26 family
E2544_22985	COG0481	GTPase activity
E2544_22990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2544_23015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2544_23020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2544_23030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E2544_23035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2544_23040	COG0416	fatty acid biosynthetic process
E2544_23045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E2544_23050	COG1399	metal-binding, possibly nucleic acid-binding protein
E2544_23055	COG0424	maF-like protein
E2544_23065	COG3023	N-Acetylmuramoyl-L-alanine amidase
E2544_23070	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E2544_23075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E2544_23090	COG1530	ribonuclease E activity
E2544_23105	COG2721	sulfolactate sulfo-lyase activity
E2544_23115	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E2544_23120	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E2544_23125	COG0159	tryptophan synthase activity
E2544_23130	COG0133	tryptophan synthase activity
E2544_23135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2544_23145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2544_23150	COG3228	Belongs to the MtfA family
E2544_23155	COG0655	NAD(P)H dehydrogenase (quinone) activity
E2544_23160	COG0251	oxidation-reduction process
E2544_23165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E2544_23170	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E2544_23185	COG2878	Part of a membrane complex involved in electron transport
E2544_23190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E2544_23195	COG0411	ABC transporter
E2544_23200	COG0410	ABC transporter
E2544_23210	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_23225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E2544_23240	COG0410	ABC transporter
E2544_23245	COG0411	ABC transporter
E2544_23260	COG1268	BioY protein
E2544_23265	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E2544_23270	COG1122	ATPase activity
E2544_23275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2544_23280	COG2917	probably involved in intracellular septation
E2544_23290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2544_23295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2544_23300	COG2175	clavaminate synthase activity
E2544_23315	COG1414	Transcriptional regulator
E2544_23320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E2544_23330	COG1196	nuclear chromosome segregation
E2544_23335	COG0477	Major facilitator Superfamily
E2544_23340	COG1573	uracil-dna glycosylase
E2544_23345	COG1214	PFAM Peptidase M22, glycoprotease
E2544_23350	COG0745	RESPONSE REGULATOR receiver
E2544_23355	COG2205	protein histidine kinase activity
E2544_23360	COG0450	alkyl hydroperoxide reductase
E2544_23365	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2544_23375	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E2544_23380	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E2544_23385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E2544_23390	COG0560	Phosphoserine phosphatase
E2544_23395	COG4774	siderophore transport
E2544_23405	COG1007	ATP synthesis coupled electron transport
E2544_23420	COG0713	ATP synthesis coupled electron transport
E2544_23430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2544_23435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E2544_23440	COG1034	ATP synthesis coupled electron transport
E2544_23450	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E2544_23455	COG0649	NAD binding
E2544_23460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2544_23465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2544_23470	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2544_23475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2544_23500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E2544_23525	COG1309	transcriptional regulator
E2544_23530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_23535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2544_23555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2544_23565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E2544_23575	COG1309	transcriptional regulator
E2544_23585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2544_23605	COG0726	polysaccharide deacetylase
E2544_23630	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E2544_23640	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_23645	COG0747	negative chemotaxis
E2544_23675	COG2354	Protein conserved in bacteria
E2544_23680	COG3813	Protein conserved in bacteria
E2544_23685	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
E2544_23690	COG3604	Transcriptional regulator
E2544_23700	COG0604	alcohol dehydrogenase
E2544_23705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_23710	COG0583	DNA-binding transcription factor activity
E2544_23715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2544_23725	COG0477	Major facilitator Superfamily
E2544_23735	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2544_23745	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2544_23745	COG0022	dehydrogenase e1 component
E2544_23760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_23765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_23790	COG1609	Transcriptional regulator
E2544_23795	COG2084	Dehydrogenase
E2544_23800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_23805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_23815	COG3119	arylsulfatase activity
E2544_23825	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_23830	COG2851	Citrate transporter
E2544_23840	COG0642	Histidine kinase
E2544_23870	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_23890	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_23905	COG0410	ABC transporter
E2544_23915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_23920	COG0697	spore germination
E2544_23945	COG0583	DNA-binding transcription factor activity
E2544_23950	COG1971	Probably functions as a manganese efflux pump
E2544_23955	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_23995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2544_24015	COG0747	negative chemotaxis
E2544_24020	COG0601	transmembrane transport
E2544_24025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_24030	COG0444	Belongs to the ABC transporter superfamily
E2544_24035	COG4608	Belongs to the ABC transporter superfamily
E2544_24040	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E2544_24055	COG1960	acyl-CoA dehydrogenase activity
E2544_24070	COG1024	Enoyl-CoA hydratase
E2544_24095	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E2544_24105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2544_24145	COG1126	abc transporter atp-binding protein
E2544_24155	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2544_24160	COG1177	transmembrane transport
E2544_24165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_24170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E2544_24185	COG3842	ATPase activity
E2544_24190	COG2072	flavoprotein involved in K transport
E2544_24200	COG0071	Belongs to the small heat shock protein (HSP20) family
E2544_24225	COG5383	Protein conserved in bacteria
E2544_24230	COG0583	DNA-binding transcription factor activity
E2544_24245	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E2544_24255	COG0647	UMP catabolic process
E2544_24260	COG1737	Transcriptional regulator
E2544_24265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2544_24270	COG0149	triose-phosphate isomerase activity
E2544_24275	COG3321	synthase
E2544_24275	COG0604	alcohol dehydrogenase
E2544_24295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2544_24305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_24320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2544_24335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E2544_24350	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E2544_24360	COG1183	phosphatidylcholine synthase activity
E2544_24365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E2544_24370	COG0440	acetolactate synthase activity
E2544_24375	COG0028	Belongs to the TPP enzyme family
E2544_24380	COG1289	transmembrane transporter activity
E2544_24385	COG3022	response to hydroperoxide
E2544_24390	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_24405	COG0840	transmembrane signaling receptor activity
E2544_24410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2544_24415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2544_24420	COG0477	Major facilitator Superfamily
E2544_24430	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E2544_24475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E2544_24480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E2544_24485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2544_24500	COG0601	transmembrane transport
E2544_24520	COG1737	Transcriptional regulator
E2544_24525	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E2544_24535	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E2544_24540	COG1674	ftsk spoiiie
E2544_24545	COG0492	ferredoxin-NADP+ reductase activity
E2544_24550	COG1193	negative regulation of DNA recombination
E2544_24560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2544_24580	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E2544_24585	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E2544_24590	COG2205	protein histidine kinase activity
E2544_24595	COG0745	RESPONSE REGULATOR receiver
E2544_24610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_24615	COG0840	transmembrane signaling receptor activity
E2544_24640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2544_24665	COG0612	Peptidase, M16
E2544_24675	COG0484	heat shock protein binding
E2544_24680	COG0443	Heat shock 70 kDa protein
E2544_24690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E2544_24700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E2544_24705	COG1420	regulation of RNA biosynthetic process
E2544_24710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E2544_24715	COG0497	DNA recombination
E2544_24720	COG0735	belongs to the Fur family
E2544_24725	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2544_24730	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E2544_24760	COG0583	DNA-binding transcription factor activity
E2544_24800	COG1053	succinate dehydrogenase
E2544_24815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E2544_24825	COG3188	usher protein
E2544_24830	COG3121	Chaperone
E2544_24840	COG2197	response regulator
E2544_24850	COG2199	diguanylate cyclase activity
E2544_24850	COG2202	Pas domain
E2544_24850	COG2200	EAL domain
E2544_24855	COG0784	Response regulator, receiver
E2544_24855	COG2205	protein histidine kinase activity
E2544_24860	COG3969	phosphoadenosine phosphosulfate
E2544_24865	COG1475	DNA binding
E2544_24920	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E2544_24925	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E2544_24930	COG0167	dihydroorotate dehydrogenase activity
E2544_24945	COG1414	Transcriptional regulator
E2544_24950	COG1546	Belongs to the CinA family
E2544_24950	COG1058	Belongs to the CinA family
E2544_24965	COG0513	Belongs to the DEAD box helicase family
E2544_24995	COG0429	hydrolase of the alpha beta-hydrolase fold
E2544_25000	COG4783	chaperone-mediated protein folding
E2544_25015	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2544_25020	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E2544_25035	COG0006	proline dipeptidase activity
E2544_25045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_25065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E2544_25070	COG0632	four-way junction helicase activity
E2544_25075	COG1090	epimerase
E2544_25085	COG2255	four-way junction helicase activity
E2544_25095	COG0745	RESPONSE REGULATOR receiver
E2544_25105	COG0514	ATP-dependent DNA helicase (RecQ)
E2544_25115	COG1271	oxidase subunit
E2544_25120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2544_25125	COG0850	regulation of cytokinetic process
E2544_25130	COG2894	cell division
E2544_25135	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E2544_25150	COG0488	(ABC) transporter
E2544_25170	COG4608	Belongs to the ABC transporter superfamily
E2544_25175	COG0444	Belongs to the ABC transporter superfamily
E2544_25180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_25190	COG4166	transmembrane transport
E2544_25220	COG4638	Rieske (2fe-2S)
E2544_25245	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E2544_25250	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_25265	COG0411	ABC transporter
E2544_25270	COG0410	ABC transporter
E2544_25275	COG0463	Glycosyl transferase, family 2
E2544_25275	COG1216	Glycosyl transferase, family 2
E2544_25300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E2544_25335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E2544_25340	COG1538	Outer membrane efflux protein
E2544_25345	COG0577	efflux transmembrane transporter activity
E2544_25345	COG1136	(ABC) transporter
E2544_25350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_25365	COG0259	pyridoxamine-phosphate oxidase activity
E2544_25375	COG0579	oxidoreductase
E2544_25385	COG0659	secondary active sulfate transmembrane transporter activity
E2544_25390	COG0583	DNA-binding transcription factor activity
E2544_25395	COG1960	acyl-CoA dehydrogenase activity
E2544_25400	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_25405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_25410	COG0405	Gamma-glutamyltransferase
E2544_25420	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_25430	COG0114	fumarate hydratase activity
E2544_25435	COG0802	atpase or kinase
E2544_25440	COG0860	N-Acetylmuramoyl-L-alanine amidase
E2544_25445	COG0586	Pfam SNARE associated Golgi protein
E2544_25450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E2544_25455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E2544_25460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E2544_25475	COG0617	tRNA 3'-terminal CCA addition
E2544_25485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2544_25500	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
E2544_25505	COG0583	DNA-binding transcription factor activity
E2544_25510	COG1024	Enoyl-CoA hydratase
E2544_25520	COG1960	acyl-CoA dehydrogenase activity
E2544_25535	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_25555	COG0583	DNA-binding transcription factor activity
E2544_25560	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_25565	COG2030	dehydratase
E2544_25570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_25580	COG1024	Enoyl-CoA hydratase
E2544_25585	COG0752	glycyl-tRNA synthetase alpha subunit
E2544_25590	COG0751	glycine-tRNA ligase activity
E2544_25595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E2544_25600	COG0204	Acyl-transferase
E2544_25620	COG0242	peptide deformylase activity
E2544_25630	COG0700	Nucleoside recognition
E2544_25635	COG0469	pyruvate kinase activity
E2544_25640	COG1929	Belongs to the glycerate kinase type-1 family
E2544_25645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E2544_25650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2544_25665	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E2544_25690	COG2154	pterin-4-alpha-carbinolamine dehydratase
E2544_25720	COG1522	sequence-specific DNA binding
E2544_25735	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_25750	COG2982	Protein involved in outer membrane biogenesis
E2544_25755	COG1368	sulfuric ester hydrolase activity
E2544_25760	COG2818	Glycosylase
E2544_25780	COG0735	belongs to the Fur family
E2544_25805	COG2011	ABC-type metal ion transport system permease component
E2544_25810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E2544_25815	COG1501	Belongs to the glycosyl hydrolase 31 family
E2544_25820	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E2544_25820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_25830	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_25835	COG1473	amidohydrolase
E2544_25845	COG2855	membrane
E2544_25850	COG1607	acyl-coa hydrolase
E2544_25855	COG2239	Acts as a magnesium transporter
E2544_25870	COG1522	sequence-specific DNA binding
E2544_25875	COG0300	oxidoreductase activity
E2544_25885	COG0028	Belongs to the TPP enzyme family
E2544_25890	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_25905	COG0653	protein targeting
E2544_25910	COG0739	heme binding
E2544_25920	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E2544_25925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E2544_25935	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E2544_25940	COG1181	Belongs to the D-alanine--D-alanine ligase family
E2544_25945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2544_25950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E2544_25960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E2544_25965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2544_25970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E2544_25980	COG3116	cell division
E2544_25985	COG0275	rRNA processing
E2544_25990	COG2001	Belongs to the MraZ family
E2544_26005	COG0418	dihydroorotase activity
E2544_26010	COG1473	amidohydrolase
E2544_26070	COG1522	sequence-specific DNA binding
E2544_26080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2544_26085	COG4654	Cytochrome c, class I
E2544_26090	COG0129	dihydroxy-acid dehydratase activity
E2544_26135	COG2084	Dehydrogenase
E2544_26140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E2544_26150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_26185	COG0824	Thioesterase
E2544_26190	COG0811	peptide transport
E2544_26195	COG0848	biopolymer transport protein
E2544_26205	COG0823	Involved in the tonB-independent uptake of proteins
E2544_26220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2544_26225	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E2544_26240	COG1522	sequence-specific DNA binding
E2544_26250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2544_26265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_26270	COG0697	spore germination
E2544_26280	COG1346	cytolysis
E2544_26285	COG1380	Effector of murein hydrolase LrgA
E2544_26290	COG0583	DNA-binding transcription factor activity
E2544_26300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_26305	COG1129	ABC transporter
E2544_26320	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_26340	COG0583	DNA-binding transcription factor activity
E2544_26360	COG0463	Glycosyl transferase, family 2
E2544_26370	COG0786	glutamate:sodium symporter activity
E2544_26385	COG1671	Belongs to the UPF0178 family
E2544_26405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E2544_26410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2544_26415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_26420	COG0328	RNA-DNA hybrid ribonuclease activity
E2544_26425	COG2226	methyltransferase
E2544_26435	COG0741	lytic transglycosylase activity
E2544_26435	COG1388	LysM domain
E2544_26440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E2544_26445	COG3608	succinylglutamate desuccinylase aspartoacylase
E2544_26470	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_26495	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_26515	COG2719	SpoVR family
E2544_26520	COG2718	Belongs to the UPF0229 family
E2544_26525	COG2766	serine protein kinase
E2544_26540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2544_26540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2544_26550	COG2207	Transcriptional regulator
E2544_26555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E2544_26560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E2544_26570	COG1881	PFAM PEBP family protein
E2544_26575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E2544_26585	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E2544_26590	COG0316	Belongs to the HesB IscA family
E2544_26600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E2544_26605	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E2544_26610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E2544_26625	COG4177	L-phenylalanine transmembrane transporter activity
E2544_26630	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_26640	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E2544_26645	COG0312	modulator of DNA gyrase
E2544_26665	COG1116	anion transmembrane transporter activity
E2544_26670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_26675	COG1335	isochorismatase
E2544_26680	COG0045	succinate-CoA ligase (ADP-forming) activity
E2544_26680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E2544_26680	COG1042	CoA-binding domain protein
E2544_26685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2544_26700	COG0583	DNA-binding transcription factor activity
E2544_26710	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_26715	COG1522	sequence-specific DNA binding
E2544_26740	COG0762	integral membrane protein
E2544_26745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E2544_26750	COG1696	Membrane protein involved in D-alanine export
E2544_26775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E2544_26775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E2544_26785	COG2264	protein methyltransferase activity
E2544_26790	COG0439	Biotin carboxylase
E2544_26795	COG0511	ligase activity, forming carbon-carbon bonds
E2544_26800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E2544_26805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2544_26810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2544_26815	COG3150	esterase
E2544_26820	COG0557	exoribonuclease II activity
E2544_26825	COG0745	RESPONSE REGULATOR receiver
E2544_26830	COG0642	Histidine kinase
E2544_26835	COG1840	ABC-type Fe3 transport system, periplasmic component
E2544_26840	COG1175	transmembrane transport
E2544_26855	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E2544_26860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E2544_26870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E2544_26875	COG1126	abc transporter atp-binding protein
E2544_26880	COG0765	amino acid transport
E2544_26890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_26900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_26920	COG0540	Belongs to the ATCase OTCase family
E2544_26925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E2544_26930	COG1678	Uncharacterized ACR, COG1678
E2544_26940	COG0351	phosphomethylpyrimidine kinase
E2544_26940	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E2544_26940	COG0352	thiamine-phosphate diphosphorylase activity
E2544_26950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E2544_26955	COG0741	lytic transglycosylase activity
E2544_26965	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_26970	COG1335	isochorismatase
E2544_26975	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E2544_26980	COG4638	Rieske (2fe-2S)
E2544_26985	COG0412	Dienelactone hydrolase
E2544_27020	COG1024	Enoyl-CoA hydratase
E2544_27025	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_27035	COG2202	Pas domain
E2544_27035	COG2199	diguanylate cyclase activity
E2544_27035	COG2200	EAL domain
E2544_27040	COG3706	GGDEF domain
E2544_27060	COG0410	ABC transporter
E2544_27075	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_27095	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E2544_27110	COG0410	ABC transporter
E2544_27135	COG0683	leucine binding
E2544_27140	COG0154	amidase activity
E2544_27145	COG0583	DNA-binding transcription factor activity
E2544_27150	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_27160	COG1538	Outer membrane efflux protein
E2544_27185	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E2544_27190	COG0237	dephospho-CoA kinase activity
E2544_27210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E2544_27215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E2544_27225	COG0477	Major facilitator Superfamily
E2544_27230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E2544_27235	COG0129	dihydroxy-acid dehydratase activity
E2544_27245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2544_27250	COG0583	DNA-binding transcription factor activity
E2544_27265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E2544_27270	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E2544_27275	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_27280	COG2031	fatty acid transporter
E2544_27285	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_27290	COG1414	Transcriptional regulator
E2544_27300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2544_27315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2544_27330	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E2544_27335	COG2890	protein-(glutamine-N5) methyltransferase activity
E2544_27340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E2544_27345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E2544_27355	COG3264	Mechanosensitive ion channel
E2544_27355	COG1196	nuclear chromosome segregation
E2544_27365	COG1132	(ABC) transporter
E2544_27395	COG1522	sequence-specific DNA binding
E2544_27405	COG5006	permease, DMT superfamily
E2544_27420	COG3622	Belongs to the hyi family
E2544_27425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2544_27430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_27435	COG0410	ABC transporter
E2544_27455	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E2544_27460	COG1012	belongs to the aldehyde dehydrogenase family
E2544_27475	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2544_27490	COG0022	dehydrogenase e1 component
E2544_27495	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_27520	COG2186	Transcriptional regulator
E2544_27525	COG3395	kinase activity
E2544_27530	COG2084	Dehydrogenase
E2544_27535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2544_27540	COG3622	Belongs to the hyi family
E2544_27545	COG2271	Major facilitator Superfamily
E2544_27550	COG0235	Class ii aldolase
E2544_27565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E2544_27570	COG0560	Phosphoserine phosphatase
E2544_27580	COG2084	Dehydrogenase
E2544_27585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2544_27590	COG0683	leucine binding
E2544_27605	COG0411	ABC transporter
E2544_27620	COG2226	methyltransferase
E2544_27620	COG1073	alpha beta
E2544_27630	COG0523	cobalamin synthesis protein
E2544_27635	COG1335	isochorismatase
E2544_27640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2544_27645	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E2544_27650	COG1802	Transcriptional regulator
E2544_27655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E2544_27660	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_27665	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_27675	COG4774	siderophore transport
E2544_27690	COG4585	Histidine kinase
E2544_27700	COG3119	arylsulfatase activity
E2544_27710	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_27720	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E2544_27730	COG0142	geranyltranstransferase activity
E2544_27745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E2544_27750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E2544_27755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E2544_27760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E2544_27775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2544_27780	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E2544_27790	COG2186	Transcriptional regulator
E2544_27800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E2544_27805	COG0793	Belongs to the peptidase S41A family
E2544_27810	COG4942	peptidase
E2544_27815	COG0588	phosphoglycerate mutase activity
E2544_27825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E2544_27830	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E2544_27835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E2544_27845	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E2544_27850	COG1040	competence protein
E2544_27855	COG2226	methyltransferase
E2544_27860	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E2544_27865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E2544_27870	COG0569	domain protein
E2544_27875	COG2204	response regulator
E2544_27880	COG5000	phosphorelay sensor kinase activity
E2544_27890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2544_27895	COG1280	lysine exporter protein (LysE YggA)
E2544_27910	COG2076	Multidrug Resistance protein
E2544_27915	COG1733	regulation of RNA biosynthetic process
E2544_27935	COG0546	phosphoglycolate phosphatase activity
E2544_27945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E2544_27950	COG0242	peptide deformylase activity
E2544_27955	COG0758	DNA mediated transformation
E2544_27970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_27975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_27980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E2544_27995	COG1238	metal cluster binding
E2544_28000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E2544_28005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2544_28020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E2544_28025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E2544_28030	COG4988	ABC transporter
E2544_28040	COG1294	oxidase, subunit
E2544_28045	COG1271	oxidase subunit
E2544_28055	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E2544_28065	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E2544_28080	COG1137	ATPase activity
E2544_28085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E2544_28095	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E2544_28100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_28115	COG1660	Displays ATPase and GTPase activities
E2544_28125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E2544_28140	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E2544_28145	COG2823	Periplasmic or secreted lipoprotein
E2544_28150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2544_28160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E2544_28170	COG1309	transcriptional regulator
E2544_28175	COG0471	metal ion transport
E2544_28180	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E2544_28185	COG0772	Belongs to the SEDS family
E2544_28190	COG0768	penicillin binding
E2544_28200	COG1792	Involved in formation and maintenance of cell shape
E2544_28205	COG1077	Cell shape determining protein MreB Mrl
E2544_28210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E2544_28215	COG0154	amidase activity
E2544_28220	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E2544_28230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E2544_28235	COG0708	Exodeoxyribonuclease III
E2544_28250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E2544_28260	COG0583	DNA-binding transcription factor activity
E2544_28275	COG0583	DNA-binding transcription factor activity
E2544_28290	COG0411	ABC transporter
E2544_28300	COG1764	response to oxidative stress
E2544_28305	COG1846	Transcriptional regulator
E2544_28350	COG0730	response to heat
E2544_28370	COG0640	Transcriptional regulator
E2544_28385	COG0456	acetyltransferase
E2544_28405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2544_28410	COG3189	MarR family transcriptional regulator
E2544_28415	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_28420	COG0352	thiamine-phosphate diphosphorylase activity
E2544_28420	COG0351	phosphomethylpyrimidine kinase
E2544_28420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E2544_28425	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E2544_28430	COG0513	Belongs to the DEAD box helicase family
E2544_28440	COG0617	tRNA 3'-terminal CCA addition
E2544_28450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E2544_28455	COG2308	Evidence 4 Homologs of previously reported genes of
E2544_28465	COG1305	Transglutaminase-like
E2544_28490	COG2301	Belongs to the HpcH HpaI aldolase family
E2544_28495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_28500	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_28505	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E2544_28510	COG1950	PFAM Membrane protein of
E2544_28515	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E2544_28530	COG0596	Alpha beta hydrolase
E2544_28535	COG0066	3-isopropylmalate dehydratase activity
E2544_28545	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_28550	COG0583	DNA-binding transcription factor activity
E2544_28555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2544_28595	COG0477	Major facilitator Superfamily
E2544_28600	COG0154	amidase activity
E2544_28605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E2544_28620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E2544_28630	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E2544_28635	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E2544_28660	COG0735	belongs to the Fur family
E2544_28665	COG0523	cobalamin synthesis protein
E2544_28670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E2544_28675	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E2544_28680	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E2544_28690	COG2096	Adenosyltransferase
E2544_28705	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E2544_28715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E2544_28730	COG0321	lipoyl(octanoyl) transferase activity
E2544_28745	COG1686	Belongs to the peptidase S11 family
E2544_28780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E2544_28790	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E2544_28805	COG0859	PFAM glycosyl transferase family 9
E2544_28810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2544_28825	COG0438	transferase activity, transferring glycosyl groups
E2544_28830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2544_28845	COG0297	glycogen (starch) synthase activity
E2544_28865	COG2076	Multidrug Resistance protein
E2544_28875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2544_28890	COG2814	Major facilitator Superfamily
E2544_28895	COG0697	spore germination
E2544_28905	COG3568	Endonuclease Exonuclease Phosphatase
E2544_28910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E2544_28940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2544_28955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2544_28970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_28975	COG1956	GAF domain-containing protein
E2544_28980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_29005	COG2186	Transcriptional regulator
E2544_29010	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E2544_29040	COG0629	single-stranded DNA binding
E2544_29045	COG2814	Major facilitator Superfamily
E2544_29060	COG0583	DNA-binding transcription factor activity
E2544_29070	COG1473	amidohydrolase
E2544_29075	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E2544_29080	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E2544_29085	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E2544_29095	COG1965	Belongs to the frataxin family
E2544_29105	COG0019	diaminopimelate decarboxylase activity
E2544_29200	COG3501	Rhs element vgr protein
E2544_29230	COG1333	cytochrome c biogenesis protein
E2544_29240	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E2544_29255	COG0410	ABC transporter
E2544_29270	COG0683	leucine binding
E2544_29275	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_29290	COG4232	protein-disulfide reductase activity
E2544_29295	COG1324	tolerance protein
E2544_29300	COG0537	adenosine 5'-monophosphoramidase activity
E2544_29305	COG0203	ribosomal protein L17
E2544_29310	COG0202	RNA polymerase activity
E2544_29315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E2544_29320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E2544_29325	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E2544_29330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E2544_29335	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E2544_29340	COG0201	protein transport
E2544_29345	COG0200	Binds to the 23S rRNA
E2544_29350	COG1841	ribosomal large subunit assembly
E2544_29355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E2544_29360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E2544_29365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E2544_29370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E2544_29375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E2544_29380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E2544_29385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E2544_29390	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E2544_29405	COG2207	Transcriptional regulator
E2544_29420	COG1137	ATPase activity
E2544_29445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E2544_29450	COG0255	Belongs to the universal ribosomal protein uL29 family
E2544_29455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E2544_29460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E2544_29465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E2544_29470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E2544_29475	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E2544_29480	COG0089	rRNA binding
E2544_29485	COG0088	Forms part of the polypeptide exit tunnel
E2544_29490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E2544_29495	COG0051	transcription antitermination factor activity, RNA binding
E2544_29500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2544_29505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2544_29510	COG0049	tRNA binding
E2544_29515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E2544_29520	COG0745	RESPONSE REGULATOR receiver
E2544_29535	COG5002	protein histidine kinase activity
E2544_29550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E2544_29555	COG0085	RNA polymerase activity
E2544_29560	COG0222	ribosome binding
E2544_29565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E2544_29570	COG0081	regulation of translation
E2544_29575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E2544_29585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2544_29595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2544_29620	COG1012	belongs to the aldehyde dehydrogenase family
E2544_29635	COG1840	ABC-type Fe3 transport system, periplasmic component
E2544_29640	COG3842	ATPase activity
E2544_29650	COG1349	DNA-binding transcription factor activity
E2544_29675	COG0583	DNA-binding transcription factor activity
E2544_29680	COG0252	asparaginase activity
E2544_29685	COG1475	DNA binding
E2544_29695	COG1192	Involved in chromosome partitioning
E2544_29700	COG0357	Ribosomal RNA small subunit methyltransferase G
E2544_29705	COG0445	tRNA wobble uridine modification
E2544_29715	COG1278	Cold shock
E2544_29720	COG3180	Ammonia monooxygenase
E2544_29725	COG0436	Aminotransferase
E2544_29745	COG0642	Histidine kinase
E2544_29755	COG0038	chloride channel
E2544_29780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E2544_29790	COG0601	transmembrane transport
E2544_29795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_29800	COG0444	Belongs to the ABC transporter superfamily
E2544_29805	COG4608	Belongs to the ABC transporter superfamily
E2544_29810	COG1473	amidohydrolase
E2544_29815	COG2175	clavaminate synthase activity
E2544_29825	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E2544_29830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_29835	COG0753	catalase activity
E2544_29845	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E2544_29850	COG0594	ribonuclease P activity
E2544_29855	COG0230	Belongs to the bacterial ribosomal protein bL34 family