locus-tag	class	description
H4P35_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H4P35_00010	COG0592	DNA-directed DNA polymerase activity
H4P35_00020	COG0583	DNA-binding transcription factor activity
H4P35_00025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_00030	COG0765	amino acid transport
H4P35_00035	COG0765	amino acid transport
H4P35_00040	COG1126	abc transporter atp-binding protein
H4P35_00065	COG1304	FMN binding
H4P35_00075	COG3842	ATPase activity
H4P35_00080	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4P35_00085	COG1177	transmembrane transport
H4P35_00140	COG1609	Transcriptional regulator
H4P35_00150	COG3842	ATPase activity
H4P35_00155	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4P35_00160	COG1177	transmembrane transport
H4P35_00185	COG0251	oxidation-reduction process
H4P35_00190	COG0402	S-adenosylhomocysteine deaminase activity
H4P35_00195	COG1079	Belongs to the binding-protein-dependent transport system permease family
H4P35_00200	COG4603	Belongs to the binding-protein-dependent transport system permease family
H4P35_00205	COG3845	ABC transporter
H4P35_00210	COG1744	ABC transporter substrate-binding protein PnrA-like
H4P35_00220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4P35_00235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4P35_00260	COG3781	membrane
H4P35_00265	COG1522	sequence-specific DNA binding
H4P35_00270	COG0028	Belongs to the TPP enzyme family
H4P35_00275	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_00280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4P35_00285	COG1116	anion transmembrane transporter activity
H4P35_00285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4P35_00295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4P35_00295	COG0551	DNA topoisomerase type I activity
H4P35_00305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4P35_00310	COG2922	Belongs to the Smg family
H4P35_00320	COG2358	TRAP transporter, solute receptor (TAXI family
H4P35_00345	COG0765	amino acid transport
H4P35_00350	COG0765	amino acid transport
H4P35_00355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_00360	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_00365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4P35_00420	COG1595	DNA-templated transcription, initiation
H4P35_00425	COG0753	catalase activity
H4P35_00465	COG0477	Major facilitator Superfamily
H4P35_00475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4P35_00480	COG0183	Belongs to the thiolase family
H4P35_00485	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H4P35_00490	COG1960	acyl-CoA dehydrogenase activity
H4P35_00495	COG1473	amidohydrolase
H4P35_00500	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_00505	COG1742	UPF0060 membrane protein
H4P35_00515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4P35_00520	COG1280	lysine exporter protein (LysE YggA)
H4P35_00545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4P35_00575	COG0395	ABC-type sugar transport system, permease component
H4P35_00580	COG1175	transmembrane transport
H4P35_00585	COG1653	transport
H4P35_00595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H4P35_00600	COG1609	Transcriptional regulator
H4P35_00605	COG0154	amidase activity
H4P35_00610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4P35_00620	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H4P35_00630	COG0583	DNA-binding transcription factor activity
H4P35_00650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H4P35_00655	COG1280	lysine exporter protein (LysE YggA)
H4P35_00660	COG0513	Belongs to the DEAD box helicase family
H4P35_00665	COG5339	Protein conserved in bacteria
H4P35_00685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_00690	COG0601	transmembrane transport
H4P35_00695	COG4166	transmembrane transport
H4P35_00700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H4P35_00710	COG2207	Transcriptional regulator
H4P35_00710	COG3708	Transcriptional regulator
H4P35_00715	COG0697	spore germination
H4P35_00720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4P35_00730	COG0583	DNA-binding transcription factor activity
H4P35_00760	COG2969	positive regulation of protein catabolic process
H4P35_00765	COG0625	glutathione transferase activity
H4P35_00770	COG2857	Cytochrome c1
H4P35_00775	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4P35_00780	COG0723	plastoquinol--plastocyanin reductase activity
H4P35_00785	COG1970	mechanosensitive ion channel activity
H4P35_00790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H4P35_00795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4P35_00810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4P35_00815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4P35_00820	COG0537	adenosine 5'-monophosphoramidase activity
H4P35_00825	COG0140	phosphoribosyl-ATP diphosphatase activity
H4P35_00830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H4P35_00835	COG0107	imidazoleglycerol-phosphate synthase activity
H4P35_00840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H4P35_00845	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H4P35_00850	COG0131	Imidazoleglycerol-phosphate dehydratase
H4P35_00855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4P35_00860	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H4P35_00865	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H4P35_00870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4P35_00880	COG0842	Transport permease protein
H4P35_00885	COG1131	(ABC) transporter
H4P35_00895	COG2853	Lipoprotein
H4P35_00900	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4P35_00905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4P35_00910	COG1127	ABC transporter
H4P35_00915	COG2070	2-Nitropropane dioxygenase
H4P35_00925	COG0477	Major facilitator Superfamily
H4P35_00930	COG0583	DNA-binding transcription factor activity
H4P35_00935	COG3047	cAMP biosynthetic process
H4P35_00945	COG0067	glutamate synthase
H4P35_00945	COG0069	glutamate synthase activity
H4P35_00945	COG0070	glutamate synthase
H4P35_00970	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H4P35_00990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4P35_01020	COG1612	heme a metabolic process
H4P35_01030	COG1999	signal sequence binding
H4P35_01050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H4P35_01055	COG2814	Major facilitator Superfamily
H4P35_01080	COG1522	sequence-specific DNA binding
H4P35_01105	COG2814	Major facilitator Superfamily
H4P35_01115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4P35_01120	COG3437	response regulator, receiver
H4P35_01125	COG0784	Response regulator, receiver
H4P35_01125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_01125	COG2198	Histidine kinase
H4P35_01125	COG2205	protein histidine kinase activity
H4P35_01165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4P35_01180	COG0154	amidase activity
H4P35_01190	COG0583	DNA-binding transcription factor activity
H4P35_01195	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_01225	COG0583	DNA-binding transcription factor activity
H4P35_01230	COG4566	intracellular signal transduction
H4P35_01240	COG2814	Major facilitator Superfamily
H4P35_01260	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H4P35_01265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H4P35_01275	COG0745	RESPONSE REGULATOR receiver
H4P35_01290	COG0789	Transcriptional regulator
H4P35_01295	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H4P35_01305	COG0596	Alpha beta hydrolase
H4P35_01320	COG0583	DNA-binding transcription factor activity
H4P35_01325	COG0861	Integral membrane protein TerC family
H4P35_01365	COG0243	molybdopterin cofactor binding
H4P35_01390	COG0154	amidase activity
H4P35_01395	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_01400	COG0583	DNA-binding transcription factor activity
H4P35_01405	COG0656	L-ascorbic acid biosynthetic process
H4P35_01410	COG0583	DNA-binding transcription factor activity
H4P35_01420	COG2814	Major facilitator Superfamily
H4P35_01425	COG0583	DNA-binding transcription factor activity
H4P35_01435	COG2423	ornithine cyclodeaminase activity
H4P35_01445	COG2200	EAL domain
H4P35_01470	COG5001	Diguanylate cyclase
H4P35_01475	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H4P35_01505	COG0840	transmembrane signaling receptor activity
H4P35_01510	COG2814	Major facilitator Superfamily
H4P35_01555	COG1802	Transcriptional regulator
H4P35_01565	COG3069	C4-dicarboxylate transmembrane transporter activity
H4P35_01570	COG1012	belongs to the aldehyde dehydrogenase family
H4P35_01590	COG3064	Membrane
H4P35_01615	COG1607	acyl-coa hydrolase
H4P35_01630	COG0437	4 iron, 4 sulfur cluster binding
H4P35_01635	COG2864	formate dehydrogenase
H4P35_01650	COG3276	selenocysteine insertion sequence binding
H4P35_01660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4P35_01665	COG1305	Transglutaminase-like
H4P35_01675	COG0583	DNA-binding transcription factor activity
H4P35_01700	COG1012	belongs to the aldehyde dehydrogenase family
H4P35_01705	COG3284	Transcriptional regulator
H4P35_01715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4P35_01720	COG0512	Glutamine amidotransferase of anthranilate synthase
H4P35_01730	COG0546	phosphoglycolate phosphatase activity
H4P35_01735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4P35_01740	COG2967	ApaG domain
H4P35_01745	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H4P35_01750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4P35_01760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4P35_01765	COG0037	tRNA processing
H4P35_01800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4P35_01805	COG1024	Enoyl-CoA hydratase
H4P35_01820	COG0356	it plays a direct role in the translocation of protons across the membrane
H4P35_01830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H4P35_01835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H4P35_01840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H4P35_01845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H4P35_01850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H4P35_01855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H4P35_01865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H4P35_01870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H4P35_01875	COG0210	DNA helicase
H4P35_01880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4P35_01890	COG2171	N-acyltransferase activity
H4P35_01895	COG2195	Cleaves the N-terminal amino acid of tripeptides
H4P35_01905	COG4608	Belongs to the ABC transporter superfamily
H4P35_01915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_01920	COG0601	transmembrane transport
H4P35_01925	COG2988	succinylglutamate desuccinylase activity
H4P35_01930	COG0747	negative chemotaxis
H4P35_01940	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H4P35_01945	COG1024	Enoyl-CoA hydratase
H4P35_01950	COG1024	Enoyl-CoA hydratase
H4P35_01975	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4P35_01990	COG0583	DNA-binding transcription factor activity
H4P35_02020	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4P35_02025	COG1802	Transcriptional regulator
H4P35_02030	COG0583	DNA-binding transcription factor activity
H4P35_02050	COG2918	glutathione biosynthetic process
H4P35_02065	COG2197	response regulator
H4P35_02075	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H4P35_02080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4P35_02090	COG2721	sulfolactate sulfo-lyase activity
H4P35_02095	COG2721	sulfolactate sulfo-lyase activity
H4P35_02100	COG2188	Transcriptional regulator
H4P35_02105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4P35_02110	COG2813	Specifically methylates the guanine in position
H4P35_02110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4P35_02115	COG2223	nitrite transmembrane transporter activity
H4P35_02125	COG2860	membrane
H4P35_02130	COG1802	Transcriptional regulator
H4P35_02140	COG1984	allophanate hydrolase subunit 2
H4P35_02145	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H4P35_02155	COG0583	DNA-binding transcription factor activity
H4P35_02160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4P35_02175	COG2132	Multicopper oxidase
H4P35_02185	COG0642	Histidine kinase
H4P35_02200	COG0745	RESPONSE REGULATOR receiver
H4P35_02205	COG2226	methyltransferase
H4P35_02220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4P35_02230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H4P35_02235	COG3547	Transposase (IS116 IS110 IS902 family)
H4P35_02240	COG3328	transposase activity
H4P35_02250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4P35_02255	COG0351	phosphomethylpyrimidine kinase
H4P35_02260	COG2022	thiamine diphosphate biosynthetic process
H4P35_02265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4P35_02270	COG4771	TonB-dependent receptor
H4P35_02285	COG2186	Transcriptional regulator
H4P35_02290	COG1063	alcohol dehydrogenase
H4P35_02295	COG4948	Mandelate Racemase Muconate Lactonizing
H4P35_02300	COG0246	Mannitol dehydrogenase
H4P35_02305	COG2226	methyltransferase
H4P35_02315	COG1194	a g-specific adenine glycosylase
H4P35_02350	COG0477	Major facilitator Superfamily
H4P35_02360	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H4P35_02365	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H4P35_02385	COG0237	dephospho-CoA kinase activity
H4P35_02390	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H4P35_02415	COG0154	amidase activity
H4P35_02430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H4P35_02505	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_02510	COG1024	Enoyl-CoA hydratase
H4P35_02550	COG4638	Rieske (2fe-2S)
H4P35_02555	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H4P35_02560	COG1335	isochorismatase
H4P35_02565	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_02575	COG0741	lytic transglycosylase activity
H4P35_02580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H4P35_02585	COG0352	thiamine-phosphate diphosphorylase activity
H4P35_02600	COG1678	Uncharacterized ACR, COG1678
H4P35_02605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H4P35_02625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4P35_02635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4P35_02640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4P35_02650	COG3842	ATPase activity
H4P35_02655	COG1175	transmembrane transport
H4P35_02675	COG0557	exoribonuclease II activity
H4P35_02680	COG3150	esterase
H4P35_02685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4P35_02690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4P35_02695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H4P35_02700	COG0511	ligase activity, forming carbon-carbon bonds
H4P35_02705	COG0439	Biotin carboxylase
H4P35_02710	COG2264	protein methyltransferase activity
H4P35_02745	COG1696	Membrane protein involved in D-alanine export
H4P35_02750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4P35_02780	COG1522	sequence-specific DNA binding
H4P35_02785	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_02795	COG0583	DNA-binding transcription factor activity
H4P35_02805	COG0477	Major facilitator Superfamily
H4P35_02810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4P35_02815	COG0045	succinate-CoA ligase (ADP-forming) activity
H4P35_02815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4P35_02815	COG1042	CoA-binding domain protein
H4P35_02820	COG1335	isochorismatase
H4P35_02825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4P35_02830	COG1116	anion transmembrane transporter activity
H4P35_02850	COG0312	modulator of DNA gyrase
H4P35_02855	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H4P35_02865	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4P35_02885	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H4P35_02890	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H4P35_02895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H4P35_02905	COG0316	Belongs to the HesB IscA family
H4P35_02910	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H4P35_02920	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H4P35_02925	COG1881	PFAM PEBP family protein
H4P35_02930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H4P35_02935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H4P35_02940	COG2207	Transcriptional regulator
H4P35_02950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4P35_02950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4P35_02955	COG2766	serine protein kinase
H4P35_02960	COG2718	Belongs to the UPF0229 family
H4P35_02965	COG2719	SpoVR family
H4P35_02980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4P35_02985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_03000	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_03025	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_03045	COG1388	LysM domain
H4P35_03045	COG0741	lytic transglycosylase activity
H4P35_03050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4P35_03055	COG2226	methyltransferase
H4P35_03060	COG0328	RNA-DNA hybrid ribonuclease activity
H4P35_03070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4P35_03075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4P35_03095	COG1671	Belongs to the UPF0178 family
H4P35_03110	COG0786	glutamate:sodium symporter activity
H4P35_03120	COG0463	Glycosyl transferase, family 2
H4P35_03125	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H4P35_03140	COG0583	DNA-binding transcription factor activity
H4P35_03155	COG0583	DNA-binding transcription factor activity
H4P35_03165	COG1346	cytolysis
H4P35_03175	COG0697	spore germination
H4P35_03180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4P35_03195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H4P35_03205	COG1522	sequence-specific DNA binding
H4P35_03220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H4P35_03225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4P35_03240	COG0823	Involved in the tonB-independent uptake of proteins
H4P35_03250	COG0848	biopolymer transport protein
H4P35_03255	COG0811	peptide transport
H4P35_03260	COG0824	Thioesterase
H4P35_03295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4P35_03310	COG2084	Dehydrogenase
H4P35_03315	COG0405	Gamma-glutamyltransferase
H4P35_03355	COG0129	dihydroxy-acid dehydratase activity
H4P35_03360	COG4654	Cytochrome c, class I
H4P35_03365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4P35_03435	COG1473	amidohydrolase
H4P35_03440	COG0418	dihydroorotase activity
H4P35_03445	COG0488	(ABC) transporter
H4P35_03455	COG2001	Belongs to the MraZ family
H4P35_03460	COG0275	rRNA processing
H4P35_03465	COG3116	cell division
H4P35_03475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4P35_03480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4P35_03485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H4P35_03495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H4P35_03500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4P35_03505	COG1181	Belongs to the D-alanine--D-alanine ligase family
H4P35_03510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H4P35_03520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H4P35_03525	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H4P35_03535	COG0739	heme binding
H4P35_03540	COG0653	protein targeting
H4P35_03555	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_03560	COG0028	Belongs to the TPP enzyme family
H4P35_03565	COG0300	oxidoreductase activity
H4P35_03570	COG1522	sequence-specific DNA binding
H4P35_03585	COG2239	Acts as a magnesium transporter
H4P35_03595	COG2855	membrane
H4P35_03605	COG1473	amidohydrolase
H4P35_03610	COG0318	PFAM AMP-dependent synthetase and ligase
H4P35_03615	COG0483	inositol monophosphate 1-phosphatase activity
H4P35_03620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4P35_03620	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H4P35_03625	COG1501	Belongs to the glycosyl hydrolase 31 family
H4P35_03630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4P35_03635	COG2011	ABC-type metal ion transport system permease component
H4P35_03660	COG2610	gluconate transmembrane transporter activity
H4P35_03675	COG0735	belongs to the Fur family
H4P35_03690	COG2818	Glycosylase
H4P35_03695	COG1368	sulfuric ester hydrolase activity
H4P35_03700	COG2982	Protein involved in outer membrane biogenesis
H4P35_03710	COG1309	transcriptional regulator
H4P35_03715	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_03735	COG3328	transposase activity
H4P35_03740	COG1401	restriction endodeoxyribonuclease activity
H4P35_03795	COG0737	Belongs to the 5'-nucleotidase family
H4P35_03810	COG2154	pterin-4-alpha-carbinolamine dehydratase
H4P35_03825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4P35_03835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4P35_03850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4P35_03855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H4P35_03860	COG3547	Transposase (IS116 IS110 IS902 family)
H4P35_03865	COG1929	Belongs to the glycerate kinase type-1 family
H4P35_03870	COG0469	pyruvate kinase activity
H4P35_03875	COG0700	Nucleoside recognition
H4P35_03885	COG0242	peptide deformylase activity
H4P35_03905	COG0204	Acyl-transferase
H4P35_03910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H4P35_03915	COG0751	glycine-tRNA ligase activity
H4P35_03920	COG0752	glycyl-tRNA synthetase alpha subunit
H4P35_03925	COG1024	Enoyl-CoA hydratase
H4P35_03935	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4P35_03940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_03945	COG2030	dehydratase
H4P35_03950	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_03980	COG0318	PFAM AMP-dependent synthetase and ligase
H4P35_03995	COG1960	acyl-CoA dehydrogenase activity
H4P35_04000	COG1960	acyl-CoA dehydrogenase activity
H4P35_04005	COG1024	Enoyl-CoA hydratase
H4P35_04010	COG0583	DNA-binding transcription factor activity
H4P35_04015	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
H4P35_04020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_04025	COG2301	Belongs to the HpcH HpaI aldolase family
H4P35_04030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4P35_04040	COG0617	tRNA 3'-terminal CCA addition
H4P35_04055	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H4P35_04060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H4P35_04065	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H4P35_04070	COG0586	Pfam SNARE associated Golgi protein
H4P35_04075	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4P35_04080	COG0802	atpase or kinase
H4P35_04085	COG0114	fumarate hydratase activity
H4P35_04095	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_04105	COG0405	Gamma-glutamyltransferase
H4P35_04110	COG0531	amino acid
H4P35_04115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_04125	COG1960	acyl-CoA dehydrogenase activity
H4P35_04130	COG0583	DNA-binding transcription factor activity
H4P35_04140	COG0579	oxidoreductase
H4P35_04150	COG0259	pyridoxamine-phosphate oxidase activity
H4P35_04165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4P35_04170	COG0577	efflux transmembrane transporter activity
H4P35_04170	COG1136	(ABC) transporter
H4P35_04175	COG1538	Outer membrane efflux protein
H4P35_04180	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H4P35_04215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4P35_04225	COG0800	Aldolase
H4P35_04240	COG0463	Glycosyl transferase, family 2
H4P35_04240	COG1216	Glycosyl transferase, family 2
H4P35_04270	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H4P35_04290	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H4P35_04295	COG4638	Rieske (2fe-2S)
H4P35_04320	COG0747	negative chemotaxis
H4P35_04325	COG0601	transmembrane transport
H4P35_04330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_04335	COG0444	Belongs to the ABC transporter superfamily
H4P35_04340	COG4608	Belongs to the ABC transporter superfamily
H4P35_04355	COG0488	(ABC) transporter
H4P35_04370	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H4P35_04375	COG2894	cell division
H4P35_04380	COG0850	regulation of cytokinetic process
H4P35_04385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4P35_04390	COG1271	oxidase subunit
H4P35_04395	COG1294	oxidase, subunit
H4P35_04400	COG0514	ATP-dependent DNA helicase (RecQ)
H4P35_04415	COG4191	Histidine kinase
H4P35_04420	COG2255	four-way junction helicase activity
H4P35_04430	COG1090	epimerase
H4P35_04435	COG0632	four-way junction helicase activity
H4P35_04440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H4P35_04460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4P35_04470	COG0006	proline dipeptidase activity
H4P35_04485	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H4P35_04490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H4P35_04505	COG4783	chaperone-mediated protein folding
H4P35_04510	COG0429	hydrolase of the alpha beta-hydrolase fold
H4P35_04540	COG0513	Belongs to the DEAD box helicase family
H4P35_04555	COG1058	Belongs to the CinA family
H4P35_04555	COG1546	Belongs to the CinA family
H4P35_04560	COG1414	Transcriptional regulator
H4P35_04575	COG0167	dihydroorotate dehydrogenase activity
H4P35_04580	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H4P35_04585	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H4P35_04650	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4P35_04655	COG0735	belongs to the Fur family
H4P35_04660	COG0497	DNA recombination
H4P35_04670	COG1420	regulation of RNA biosynthetic process
H4P35_04675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H4P35_04685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H4P35_04695	COG0443	Heat shock 70 kDa protein
H4P35_04700	COG0484	heat shock protein binding
H4P35_04715	COG0612	Peptidase, M16
H4P35_04740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4P35_04770	COG0840	transmembrane signaling receptor activity
H4P35_04775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4P35_04790	COG0745	RESPONSE REGULATOR receiver
H4P35_04795	COG2205	protein histidine kinase activity
H4P35_04800	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H4P35_04805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H4P35_04810	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H4P35_04825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4P35_04845	COG1193	negative regulation of DNA recombination
H4P35_04850	COG0492	ferredoxin-NADP+ reductase activity
H4P35_04855	COG1674	ftsk spoiiie
H4P35_04860	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H4P35_04870	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H4P35_04875	COG0517	IMP dehydrogenase activity
H4P35_04875	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H4P35_04895	COG0601	transmembrane transport
H4P35_04900	COG0747	negative chemotaxis
H4P35_04910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4P35_04915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H4P35_04920	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H4P35_04970	COG0477	Major facilitator Superfamily
H4P35_04975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4P35_04980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4P35_05000	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_05005	COG3022	response to hydroperoxide
H4P35_05010	COG1289	transmembrane transporter activity
H4P35_05015	COG0028	Belongs to the TPP enzyme family
H4P35_05020	COG0440	acetolactate synthase activity
H4P35_05025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H4P35_05030	COG1183	phosphatidylcholine synthase activity
H4P35_05040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H4P35_05045	COG1185	polyribonucleotide nucleotidyltransferase activity
H4P35_05055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4P35_05125	COG3829	transcription factor binding
H4P35_05155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_05165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4P35_05180	COG0604	alcohol dehydrogenase
H4P35_05180	COG3321	synthase
H4P35_05185	COG0149	triose-phosphate isomerase activity
H4P35_05190	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4P35_05195	COG0583	DNA-binding transcription factor activity
H4P35_05200	COG5383	Protein conserved in bacteria
H4P35_05260	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H4P35_05265	COG4608	Belongs to the ABC transporter superfamily
H4P35_05270	COG0444	Belongs to the ABC transporter superfamily
H4P35_05275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_05280	COG0601	transmembrane transport
H4P35_05285	COG0747	negative chemotaxis
H4P35_05385	COG2207	Transcriptional regulator
H4P35_05390	COG4221	oxidoreductase activity
H4P35_05410	COG2851	Citrate transporter
H4P35_05415	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_05425	COG3119	arylsulfatase activity
H4P35_05430	COG0583	DNA-binding transcription factor activity
H4P35_05450	COG1278	Cold shock
H4P35_05460	COG3604	Transcriptional regulator
H4P35_05465	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
H4P35_05475	COG2354	Protein conserved in bacteria
H4P35_05485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4P35_05500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4P35_05505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4P35_05510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4P35_05525	COG0583	DNA-binding transcription factor activity
H4P35_05540	COG1597	lipid kinase activity
H4P35_05545	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H4P35_05555	COG0287	Prephenate dehydrogenase
H4P35_05570	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H4P35_05575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4P35_05580	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4P35_05585	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4P35_05590	COG0649	NAD binding
H4P35_05595	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H4P35_05605	COG1034	ATP synthesis coupled electron transport
H4P35_05610	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H4P35_05615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4P35_05625	COG0713	ATP synthesis coupled electron transport
H4P35_05640	COG1007	ATP synthesis coupled electron transport
H4P35_05650	COG4774	siderophore transport
H4P35_05655	COG0560	Phosphoserine phosphatase
H4P35_05660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H4P35_05665	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H4P35_05670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H4P35_05680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4P35_05685	COG0450	alkyl hydroperoxide reductase
H4P35_05700	COG1214	PFAM Peptidase M22, glycoprotease
H4P35_05705	COG1573	uracil-dna glycosylase
H4P35_05710	COG0477	Major facilitator Superfamily
H4P35_05715	COG1196	nuclear chromosome segregation
H4P35_05725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H4P35_05730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4P35_05740	COG2917	probably involved in intracellular septation
H4P35_05745	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4P35_05750	COG1122	ATPase activity
H4P35_05755	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H4P35_05760	COG1268	BioY protein
H4P35_05790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4P35_05825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H4P35_05830	COG2878	Part of a membrane complex involved in electron transport
H4P35_05845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H4P35_05850	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H4P35_05855	COG0251	oxidation-reduction process
H4P35_05865	COG3228	Belongs to the MtfA family
H4P35_05870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4P35_05880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4P35_05890	COG0159	tryptophan synthase activity
H4P35_05895	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H4P35_05900	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H4P35_05905	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_05910	COG2721	sulfolactate sulfo-lyase activity
H4P35_05925	COG1530	ribonuclease E activity
H4P35_05930	COG0564	pseudouridine synthase activity
H4P35_05940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4P35_05945	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H4P35_05950	COG3023	N-Acetylmuramoyl-L-alanine amidase
H4P35_05960	COG0424	maF-like protein
H4P35_05965	COG1399	metal-binding, possibly nucleic acid-binding protein
H4P35_05970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H4P35_05975	COG0416	fatty acid biosynthetic process
H4P35_05980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4P35_05985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H4P35_05990	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_05995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4P35_06000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4P35_06025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4P35_06035	COG0681	Belongs to the peptidase S26 family
H4P35_06040	COG0571	ribonuclease III activity
H4P35_06045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H4P35_06050	COG1381	Involved in DNA repair and RecF pathway recombination
H4P35_06100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H4P35_06125	COG0583	DNA-binding transcription factor activity
H4P35_06135	COG0791	NLP P60 protein
H4P35_06145	COG3193	protein, possibly involved in utilization of glycolate and propanediol
H4P35_06155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4P35_06160	COG0697	spore germination
H4P35_06165	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H4P35_06180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4P35_06215	COG1446	asparaginase
H4P35_06220	COG4172	Belongs to the ABC transporter superfamily
H4P35_06225	COG0747	negative chemotaxis
H4P35_06235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_06260	COG0504	CTP synthase activity
H4P35_06270	COG0148	phosphopyruvate hydratase activity
H4P35_06285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H4P35_06295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4P35_06325	COG1981	membrane
H4P35_06345	COG0039	L-malate dehydrogenase activity
H4P35_06350	COG2188	Transcriptional regulator
H4P35_06355	COG2009	succinate dehydrogenase
H4P35_06360	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H4P35_06365	COG1053	succinate dehydrogenase
H4P35_06370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4P35_06375	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H4P35_06380	COG0372	Belongs to the citrate synthase family
H4P35_06385	COG3539	Fimbrial protein
H4P35_06395	COG3121	Chaperone
H4P35_06400	COG3539	Fimbrial protein
H4P35_06415	COG0281	malic enzyme
H4P35_06415	COG0280	phosphate acetyltransferase
H4P35_06425	COG1297	OPT oligopeptide transporter protein
H4P35_06430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4P35_06445	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H4P35_06450	COG1522	sequence-specific DNA binding
H4P35_06455	COG0567	Dehydrogenase, E1 component
H4P35_06460	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4P35_06465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4P35_06470	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H4P35_06475	COG1595	DNA-templated transcription, initiation
H4P35_06480	COG3712	iron ion homeostasis
H4P35_06485	COG4774	siderophore transport
H4P35_06510	COG2183	response to ionizing radiation
H4P35_06515	COG1199	ATP-dependent helicase activity
H4P35_06525	COG0564	pseudouridine synthase activity
H4P35_06530	COG1496	oxidoreductase activity
H4P35_06535	COG3243	poly(R)-hydroxyalkanoic acid synthase
H4P35_06540	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_06545	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H4P35_06560	COG0672	)-iron permease
H4P35_06575	COG2823	Periplasmic or secreted lipoprotein
H4P35_06585	COG3237	CsbD-like
H4P35_06595	COG0189	ligase activity
H4P35_06595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4P35_06600	COG1132	(ABC) transporter
H4P35_06615	COG2833	Protein of unknown function (DUF455)
H4P35_06620	COG2258	MOSC domain
H4P35_06625	COG2951	lytic endotransglycosylase activity
H4P35_06660	COG0582	viral genome integration into host DNA
H4P35_06795	COG4695	Portal protein
H4P35_06980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4P35_06995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H4P35_07005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4P35_07015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H4P35_07020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H4P35_07040	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H4P35_07045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H4P35_07050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4P35_07065	COG2951	lytic endotransglycosylase activity
H4P35_07095	COG2985	domain, Protein
H4P35_07100	COG0450	alkyl hydroperoxide reductase
H4P35_07115	COG4208	sulfate ABC transporter
H4P35_07120	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H4P35_07125	COG0175	sulfate reduction
H4P35_07155	COG0335	large ribosomal subunit rRNA binding
H4P35_07165	COG1162	GTPase activity
H4P35_07170	COG0501	Belongs to the peptidase M48B family
H4P35_07175	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H4P35_07180	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H4P35_07185	COG3327	negative regulation of DNA-templated transcription, initiation
H4P35_07190	COG3396	Phenylacetate-CoA oxygenase
H4P35_07195	COG3460	Phenylacetate-CoA oxygenase
H4P35_07200	COG3396	Phenylacetate-CoA oxygenase
H4P35_07205	COG2151	metal-sulfur cluster biosynthetic enzyme
H4P35_07210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4P35_07215	COG1012	belongs to the aldehyde dehydrogenase family
H4P35_07220	COG1024	Enoyl-CoA hydratase
H4P35_07225	COG2050	protein possibly involved in aromatic compounds catabolism
H4P35_07250	COG3483	tryptophan 2,3-dioxygenase activity
H4P35_07255	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H4P35_07260	COG2003	Belongs to the UPF0758 family
H4P35_07270	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H4P35_07275	COG0625	glutathione transferase activity
H4P35_07280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4P35_07285	COG0642	Histidine kinase
H4P35_07305	COG0523	cobalamin synthesis protein
H4P35_07310	COG0583	DNA-binding transcription factor activity
H4P35_07325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H4P35_07330	COG1187	pseudouridine synthase activity
H4P35_07335	COG0779	Required for maturation of 30S ribosomal subunits
H4P35_07340	COG0195	Participates in both transcription termination and antitermination
H4P35_07340	COG2251	uridine kinase activity
H4P35_07345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H4P35_07350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H4P35_07355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H4P35_07360	COG1217	gtp-binding protein TYPA
H4P35_07370	COG0583	DNA-binding transcription factor activity
H4P35_07385	COG0428	transporter
H4P35_07395	COG1283	sodium-dependent phosphate transmembrane transporter activity
H4P35_07400	COG1760	l-serine dehydratase
H4P35_07405	COG0501	Belongs to the peptidase M48B family
H4P35_07430	COG3842	ATPase activity
H4P35_07440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4P35_07445	COG1840	ABC-type Fe3 transport system, periplasmic component
H4P35_07450	COG0492	ferredoxin-NADP+ reductase activity
H4P35_07465	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_07475	COG1722	exodeoxyribonuclease VII activity
H4P35_07480	COG0142	geranyltranstransferase activity
H4P35_07490	COG1469	GTP cyclohydrolase I activity
H4P35_07495	COG3739	integral membrane protein
H4P35_07500	COG0360	Binds together with S18 to 16S ribosomal RNA
H4P35_07505	COG2965	DNA replication, synthesis of RNA primer
H4P35_07510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H4P35_07515	COG0359	binds to the 23S rRNA
H4P35_07525	COG0305	Participates in initiation and elongation during chromosome replication
H4P35_07535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H4P35_07570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4P35_07620	COG0540	Belongs to the ATCase OTCase family
H4P35_07625	COG3706	GGDEF domain
H4P35_07655	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H4P35_07660	COG2137	regulation of response to DNA damage stimulus
H4P35_07680	COG0045	succinate-CoA ligase (ADP-forming) activity
H4P35_07685	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H4P35_07690	COG0861	Integral membrane protein TerC family
H4P35_07695	COG0861	Integral membrane protein TerC family
H4P35_07700	COG0181	hydroxymethylbilane synthase activity
H4P35_07735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H4P35_07740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H4P35_07750	COG0436	Aminotransferase
H4P35_07770	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H4P35_07775	COG0308	aminopeptidase N
H4P35_07790	COG0312	modulator of DNA gyrase
H4P35_07795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4P35_07800	COG0277	FAD linked oxidase domain protein
H4P35_07805	COG0277	FAD linked oxidase domain protein
H4P35_07810	COG0277	FAD linked oxidase domain protein
H4P35_07815	COG0247	lactate metabolic process
H4P35_07840	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_07845	COG0583	DNA-binding transcription factor activity
H4P35_07850	COG0482	sulfurtransferase activity
H4P35_07855	COG0730	response to heat
H4P35_07860	COG0625	glutathione transferase activity
H4P35_07870	COG3909	cytochrome
H4P35_07945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4P35_07960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4P35_07965	COG0069	glutamate synthase activity
H4P35_07970	COG2391	methyltransferase activity
H4P35_08005	COG0557	exoribonuclease II activity
H4P35_08010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4P35_08020	COG3128	pkhd-type hydroxylase
H4P35_08025	COG0776	regulation of translation
H4P35_08055	COG0642	Histidine kinase
H4P35_08060	COG3158	transport of potassium into the cell
H4P35_08065	COG0137	argininosuccinate synthase activity
H4P35_08070	COG0583	DNA-binding transcription factor activity
H4P35_08095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H4P35_08100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4P35_08120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4P35_08125	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H4P35_08135	COG3642	lipopolysaccharide core region biosynthetic process
H4P35_08145	COG3842	ATPase activity
H4P35_08150	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4P35_08155	COG1177	transmembrane transport
H4P35_08185	COG1960	acyl-CoA dehydrogenase activity
H4P35_08190	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H4P35_08195	COG0704	Plays a role in the regulation of phosphate uptake
H4P35_08205	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H4P35_08210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H4P35_08210	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H4P35_08215	COG0765	amino acid transport
H4P35_08220	COG0765	amino acid transport
H4P35_08230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_08245	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_08250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4P35_08255	COG0583	DNA-binding transcription factor activity
H4P35_08265	COG0277	FAD linked oxidase domain protein
H4P35_08270	COG1643	Atp-dependent helicase
H4P35_08285	COG0438	transferase activity, transferring glycosyl groups
H4P35_08290	COG0726	polysaccharide deacetylase
H4P35_08305	COG0726	polysaccharide deacetylase
H4P35_08330	COG1132	(ABC) transporter
H4P35_08335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4P35_08335	COG0475	glutathione-regulated potassium exporter activity
H4P35_08345	COG5001	Diguanylate cyclase
H4P35_08345	COG4251	negative regulation of phosphorylation
H4P35_08345	COG3706	GGDEF domain
H4P35_08345	COG2203	Gaf domain
H4P35_08355	COG1530	ribonuclease E activity
H4P35_08385	COG2204	response regulator
H4P35_08390	COG4191	Histidine kinase
H4P35_08395	COG1301	dicarboxylic acid transport
H4P35_08405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H4P35_08410	COG0799	negative regulation of ribosome biogenesis
H4P35_08415	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H4P35_08425	COG0151	Belongs to the GarS family
H4P35_08430	COG0217	transcriptional regulatory protein
H4P35_08435	COG0433	COG0433 Predicted ATPase
H4P35_08440	COG0473	3-isopropylmalate dehydrogenase activity
H4P35_08450	COG2814	Major facilitator Superfamily
H4P35_08455	COG1566	PFAM secretion protein HlyD family protein
H4P35_08485	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H4P35_08490	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H4P35_08500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H4P35_08525	COG2311	Membrane
H4P35_08530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4P35_08555	COG0662	Cupin 2, conserved barrel domain protein
H4P35_08560	COG5285	phytanoyl-CoA dioxygenase
H4P35_08565	COG3217	Mosc domain protein beta barrel domain protein
H4P35_08565	COG0633	Ferredoxin
H4P35_08570	COG2076	Multidrug Resistance protein
H4P35_08585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4P35_08615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4P35_08635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4P35_08640	COG0425	Belongs to the sulfur carrier protein TusA family
H4P35_08650	COG0228	four-way junction DNA binding
H4P35_08655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H4P35_08660	COG0336	Belongs to the RNA methyltransferase TrmD family
H4P35_08665	COG1396	sequence-specific DNA binding
H4P35_08670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_08675	COG0765	amino acid transport
H4P35_08680	COG1126	abc transporter atp-binding protein
H4P35_08685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4P35_08690	COG0525	valine-tRNA ligase activity
H4P35_08695	COG0105	UTP biosynthetic process
H4P35_08700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H4P35_08720	COG2976	Protein conserved in bacteria
H4P35_08725	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4P35_08730	COG1160	GTP binding
H4P35_08735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4P35_08740	COG1923	regulation of RNA biosynthetic process
H4P35_08745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4P35_08750	COG0330	HflC and HflK could
H4P35_08755	COG0330	HflC and HflK could
H4P35_08760	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H4P35_08765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H4P35_08770	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H4P35_08775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H4P35_08785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4P35_08830	COG4964	Belongs to the GSP D family
H4P35_08860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H4P35_08865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4P35_08875	COG1295	ribonuclease BN
H4P35_08885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H4P35_08895	COG2205	protein histidine kinase activity
H4P35_08910	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H4P35_08940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4P35_08945	COG2274	protein secretion by the type I secretion system
H4P35_08955	COG1538	Outer membrane efflux protein
H4P35_08975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H4P35_08990	COG0101	tRNA pseudouridine synthase activity
H4P35_08995	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H4P35_09000	COG0135	phosphoribosylanthranilate isomerase activity
H4P35_09015	COG2076	Multidrug Resistance protein
H4P35_09035	COG0129	dihydroxy-acid dehydratase activity
H4P35_09040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4P35_09045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4P35_09050	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H4P35_09055	COG1609	Transcriptional regulator
H4P35_09075	COG4172	Belongs to the ABC transporter superfamily
H4P35_09080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_09085	COG0601	transmembrane transport
H4P35_09090	COG0747	negative chemotaxis
H4P35_09110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4P35_09115	COG2197	response regulator
H4P35_09120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H4P35_09125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H4P35_09140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4P35_09145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4P35_09150	COG0004	ammonium transporteR
H4P35_09155	COG0347	Belongs to the P(II) protein family
H4P35_09160	COG2960	long-chain fatty acid transporting porin activity
H4P35_09165	COG0606	chelatase, subunit chli
H4P35_09170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H4P35_09175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H4P35_09180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H4P35_09185	COG0072	phenylalanine-tRNA ligase activity
H4P35_09185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4P35_09230	COG0384	phenazine biosynthesis protein PhzF
H4P35_09235	COG0456	acetyltransferase
H4P35_09260	COG1522	sequence-specific DNA binding
H4P35_09295	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_09310	COG0583	DNA-binding transcription factor activity
H4P35_09325	COG5265	(ABC) transporter
H4P35_09330	COG0656	L-ascorbic acid biosynthetic process
H4P35_09345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4P35_09360	COG2223	nitrite transmembrane transporter activity
H4P35_09390	COG1610	YqeY-like protein
H4P35_09400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4P35_09405	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_09415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4P35_09455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H4P35_09465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4P35_09470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4P35_09485	COG2091	lysine biosynthetic process via aminoadipic acid
H4P35_09500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4P35_09510	COG0506	proline dehydrogenase activity
H4P35_09525	COG0583	DNA-binding transcription factor activity
H4P35_09535	COG0625	glutathione transferase activity
H4P35_09550	COG2814	Major facilitator Superfamily
H4P35_09555	COG3958	Transketolase
H4P35_09560	COG3959	Transketolase, thiamine diphosphate binding domain
H4P35_09565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4P35_09575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4P35_09580	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_09585	COG0583	DNA-binding transcription factor activity
H4P35_09590	COG1960	acyl-CoA dehydrogenase activity
H4P35_09595	COG0318	PFAM AMP-dependent synthetase and ligase
H4P35_09605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H4P35_09620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4P35_09630	COG3245	cytochrome
H4P35_09635	COG1280	lysine exporter protein (LysE YggA)
H4P35_09650	COG1280	lysine exporter protein (LysE YggA)
H4P35_09670	COG0697	spore germination
H4P35_09675	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
H4P35_09680	COG0697	spore germination
H4P35_09695	COG1024	Enoyl-CoA hydratase
H4P35_09700	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_09710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4P35_09715	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H4P35_09720	COG0667	Aldo Keto reductase
H4P35_09725	COG0583	DNA-binding transcription factor activity
H4P35_09745	COG0583	DNA-binding transcription factor activity
H4P35_09785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4P35_09815	COG4133	protoheme IX ABC transporter activity
H4P35_09820	COG3005	denitrification pathway
H4P35_09825	COG3043	anaerobic respiration
H4P35_09845	COG3246	L-lysine catabolic process to acetate
H4P35_09850	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4P35_09855	COG0583	DNA-binding transcription factor activity
H4P35_09860	COG4774	siderophore transport
H4P35_09870	COG1595	DNA-templated transcription, initiation
H4P35_09895	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4P35_09905	COG0154	amidase activity
H4P35_09910	COG0583	DNA-binding transcription factor activity
H4P35_09920	COG0129	dihydroxy-acid dehydratase activity
H4P35_09925	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_09930	COG5001	Diguanylate cyclase
H4P35_09935	COG1024	Enoyl-CoA hydratase
H4P35_09940	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_09945	COG0583	DNA-binding transcription factor activity
H4P35_09950	COG2610	gluconate transmembrane transporter activity
H4P35_09970	COG2188	Transcriptional regulator
H4P35_09975	COG0318	PFAM AMP-dependent synthetase and ligase
H4P35_09990	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_09995	COG4977	sequence-specific DNA binding
H4P35_10005	COG5265	(ABC) transporter
H4P35_10010	COG1132	(ABC) transporter
H4P35_10025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4P35_10035	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_10040	COG2207	Transcriptional regulator
H4P35_10065	COG0583	DNA-binding transcription factor activity
H4P35_10125	COG2186	Transcriptional regulator
H4P35_10135	COG0307	riboflavin synthase, alpha
H4P35_10145	COG0154	amidase activity
H4P35_10150	COG0747	negative chemotaxis
H4P35_10155	COG0601	transmembrane transport
H4P35_10160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_10165	COG4172	Belongs to the ABC transporter superfamily
H4P35_10175	COG0657	acetylesterase activity
H4P35_10180	COG2808	Putative FMN-binding domain
H4P35_10185	COG0235	Class ii aldolase
H4P35_10190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H4P35_10195	COG0747	negative chemotaxis
H4P35_10205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4P35_10225	COG4753	response regulator
H4P35_10225	COG2207	Transcriptional regulator
H4P35_10235	COG0789	Transcriptional regulator
H4P35_10250	COG0022	dehydrogenase e1 component
H4P35_10270	COG0165	Argininosuccinate lyase
H4P35_10275	COG0668	transmembrane transport
H4P35_10335	COG2165	general secretion pathway protein
H4P35_10365	COG0583	DNA-binding transcription factor activity
H4P35_10375	COG0747	negative chemotaxis
H4P35_10380	COG0601	transmembrane transport
H4P35_10385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_10390	COG4172	Belongs to the ABC transporter superfamily
H4P35_10395	COG1280	lysine exporter protein (LysE YggA)
H4P35_10425	COG2188	Transcriptional regulator
H4P35_10455	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4P35_10460	COG0066	3-isopropylmalate dehydratase activity
H4P35_10490	COG3161	chorismate lyase activity
H4P35_10495	COG1187	pseudouridine synthase activity
H4P35_10500	COG0583	DNA-binding transcription factor activity
H4P35_10525	COG1999	signal sequence binding
H4P35_10530	COG0339	signal peptide processing
H4P35_10535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H4P35_10540	COG4566	intracellular signal transduction
H4P35_10555	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4P35_10560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4P35_10565	COG2807	transmembrane transport
H4P35_10570	COG1846	Transcriptional regulator
H4P35_10615	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H4P35_10625	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4P35_10640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4P35_10640	COG4797	methyltransferase
H4P35_10645	COG1191	sigma factor activity
H4P35_10670	COG0745	RESPONSE REGULATOR receiver
H4P35_10680	COG0835	chemotaxis
H4P35_10685	COG0840	transmembrane signaling receptor activity
H4P35_10690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H4P35_10695	COG2201	protein-glutamate methylesterase activity
H4P35_10700	COG0745	RESPONSE REGULATOR receiver
H4P35_10705	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H4P35_10715	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4P35_10720	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4P35_10735	COG2747	anti-sigma28 factor FlgM
H4P35_10750	COG1558	bacterial-type flagellum-dependent cell motility
H4P35_10760	COG1749	Flagellar hook protein flgE
H4P35_10765	COG4787	bacterial-type flagellum-dependent cell motility
H4P35_10785	COG1705	Flagellar rod assembly protein muramidase FlgJ
H4P35_10785	COG3951	Flagellar rod assembly protein muramidase FlgJ
H4P35_10805	COG0840	transmembrane signaling receptor activity
H4P35_10815	COG0840	transmembrane signaling receptor activity
H4P35_10820	COG0840	transmembrane signaling receptor activity
H4P35_10830	COG1987	bacterial-type flagellum assembly
H4P35_10875	COG1317	bacterial-type flagellum organization
H4P35_10880	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4P35_10890	COG1677	Flagellar hook-basal body complex protein FliE
H4P35_10900	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4P35_10920	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H4P35_10940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_10955	COG0285	dihydrofolate synthase activity
H4P35_10975	COG1451	nucleotide metabolic process
H4P35_10980	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H4P35_10990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H4P35_10995	COG0024	Methionine aminopeptidase
H4P35_11000	COG0052	Belongs to the universal ribosomal protein uS2 family
H4P35_11005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H4P35_11010	COG0528	UMP kinase activity
H4P35_11015	COG0233	cytoplasmic translational termination
H4P35_11020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H4P35_11025	COG0575	Belongs to the CDS family
H4P35_11030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H4P35_11035	COG0750	zinc metalloprotease
H4P35_11040	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4P35_11045	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H4P35_11050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4P35_11055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H4P35_11070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H4P35_11075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4P35_11110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4P35_11110	COG2169	Transcriptional regulator
H4P35_11115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4P35_11115	COG0519	Catalyzes the synthesis of GMP from XMP
H4P35_11125	COG0330	HflC and HflK could
H4P35_11135	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H4P35_11140	COG2867	negative regulation of translational initiation
H4P35_11150	COG1960	acyl-CoA dehydrogenase activity
H4P35_11155	COG1024	Enoyl-CoA hydratase
H4P35_11180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4P35_11185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H4P35_11190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H4P35_11195	COG0084	hydrolase, TatD family'
H4P35_11210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_11215	COG0765	amino acid transport
H4P35_11220	COG1126	abc transporter atp-binding protein
H4P35_11225	COG0010	Belongs to the arginase family
H4P35_11230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4P35_11255	COG0625	glutathione transferase activity
H4P35_11265	COG1522	sequence-specific DNA binding
H4P35_11270	COG0386	Belongs to the glutathione peroxidase family
H4P35_11280	COG0840	transmembrane signaling receptor activity
H4P35_11290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_11320	COG0513	Belongs to the DEAD box helicase family
H4P35_11330	COG1414	Transcriptional regulator
H4P35_11345	COG0747	negative chemotaxis
H4P35_11350	COG0601	transmembrane transport
H4P35_11355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_11365	COG4608	Belongs to the ABC transporter superfamily
H4P35_11370	COG1228	amidohydrolase
H4P35_11390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4P35_11395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4P35_11400	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H4P35_11405	COG4521	taurine ABC transporter
H4P35_11425	COG1966	Carbon starvation protein
H4P35_11430	COG2879	small protein
H4P35_11435	COG3547	Transposase (IS116 IS110 IS902 family)
H4P35_11460	COG0783	Belongs to the Dps family
H4P35_11470	COG0384	phenazine biosynthesis protein PhzF
H4P35_11490	COG0583	DNA-binding transcription factor activity
H4P35_11500	COG0154	amidase activity
H4P35_11510	COG0251	oxidation-reduction process
H4P35_11515	COG0583	DNA-binding transcription factor activity
H4P35_11520	COG2199	diguanylate cyclase activity
H4P35_11520	COG2203	Gaf domain
H4P35_11530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4P35_11535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4P35_11545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4P35_11550	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
H4P35_11555	COG0745	RESPONSE REGULATOR receiver
H4P35_11560	COG5002	protein histidine kinase activity
H4P35_11565	COG0574	Belongs to the PEP-utilizing enzyme family
H4P35_11565	COG3848	Pyruvate phosphate dikinase
H4P35_11575	COG0697	spore germination
H4P35_11585	COG4941	Belongs to the sigma-70 factor family
H4P35_11595	COG3795	YCII-related domain
H4P35_11605	COG3795	YCII-related domain
H4P35_11620	COG3047	cAMP biosynthetic process
H4P35_11620	COG2885	chlorophyll binding
H4P35_11630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4P35_11640	COG1683	Conserved Protein
H4P35_11655	COG1309	transcriptional regulator
H4P35_11660	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_11665	COG0668	transmembrane transport
H4P35_11705	COG4608	Belongs to the ABC transporter superfamily
H4P35_11710	COG0444	Belongs to the ABC transporter superfamily
H4P35_11715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_11720	COG0601	transmembrane transport
H4P35_11730	COG1802	Transcriptional regulator
H4P35_11735	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H4P35_11745	COG0667	Aldo Keto reductase
H4P35_11755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4P35_11760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4P35_11780	COG1414	Transcriptional regulator
H4P35_11810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4P35_11815	COG0436	Aminotransferase
H4P35_11820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_11825	COG0765	amino acid transport
H4P35_11830	COG0765	amino acid transport
H4P35_11835	COG1126	abc transporter atp-binding protein
H4P35_11850	COG0587	DNA-directed DNA polymerase activity
H4P35_11865	COG0400	carboxylic ester hydrolase activity
H4P35_11875	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_11885	COG0028	Belongs to the TPP enzyme family
H4P35_11900	COG1566	PFAM secretion protein HlyD family protein
H4P35_11920	COG0720	synthase
H4P35_11925	COG0602	queuosine metabolic process
H4P35_11945	COG1902	pentaerythritol trinitrate reductase activity
H4P35_11990	COG0842	Transport permease protein
H4P35_11995	COG1131	(ABC) transporter
H4P35_12005	COG1309	transcriptional regulator
H4P35_12010	COG2130	NADP-dependent
H4P35_12015	COG0693	protein deglycase activity
H4P35_12035	COG3842	ATPase activity
H4P35_12040	COG3842	ATPase activity
H4P35_12050	COG0395	ABC-type sugar transport system, permease component
H4P35_12070	COG2199	diguanylate cyclase activity
H4P35_12070	COG2203	Gaf domain
H4P35_12075	COG3634	alkyl hydroperoxide reductase activity
H4P35_12085	COG3387	PFAM Glycoside hydrolase 15-related
H4P35_12090	COG1960	acyl-CoA dehydrogenase activity
H4P35_12125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4P35_12130	COG0420	3'-5' exonuclease activity
H4P35_12155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4P35_12155	COG2111	Na H antiporter
H4P35_12160	COG1006	Multisubunit Na H antiporter MnhC subunit
H4P35_12165	COG0651	ATP synthesis coupled electron transport
H4P35_12170	COG1863	multisubunit Na H antiporter MnhE subunit
H4P35_12175	COG2212	antiporter activity
H4P35_12180	COG1320	monovalent cation:proton antiporter activity
H4P35_12195	COG0590	tRNA wobble adenosine to inosine editing
H4P35_12200	COG1619	proteins homologs of microcin C7 resistance protein MccF
H4P35_12205	COG0488	(ABC) transporter
H4P35_12240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4P35_12245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4P35_12255	COG2252	PERMEase
H4P35_12260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H4P35_12265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H4P35_12300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H4P35_12305	COG0789	Transcriptional regulator
H4P35_12320	COG0678	peroxiredoxin activity
H4P35_12320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H4P35_12330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H4P35_12335	COG0584	glycerophosphoryl diester phosphodiesterase
H4P35_12345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4P35_12355	COG4181	ATPase activity
H4P35_12370	COG0583	DNA-binding transcription factor activity
H4P35_12385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4P35_12400	COG4336	lyase activity
H4P35_12410	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H4P35_12450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_12455	COG0765	amino acid transport
H4P35_12460	COG1126	abc transporter atp-binding protein
H4P35_12465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4P35_12470	COG1758	RNA polymerase activity
H4P35_12475	COG0194	GDP metabolic process
H4P35_12480	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_12485	COG0791	NLP P60 protein
H4P35_12490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4P35_12495	COG0833	amino acid
H4P35_12500	COG1561	YicC-like family, N-terminal region
H4P35_12505	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H4P35_12515	COG1960	acyl-CoA dehydrogenase activity
H4P35_12525	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H4P35_12530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H4P35_12535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4P35_12540	COG0174	glutamine synthetase
H4P35_12550	COG2204	response regulator
H4P35_12555	COG0583	DNA-binding transcription factor activity
H4P35_12560	COG1741	Belongs to the pirin family
H4P35_12565	COG1741	Belongs to the pirin family
H4P35_12590	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_12600	COG3842	ATPase activity
H4P35_12610	COG1840	ABC-type Fe3 transport system, periplasmic component
H4P35_12645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4P35_12655	COG0783	Belongs to the Dps family
H4P35_12670	COG3842	ATPase activity
H4P35_12675	COG0395	ABC-type sugar transport system, permease component
H4P35_12680	COG1175	transmembrane transport
H4P35_12685	COG1653	transport
H4P35_12690	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H4P35_12720	COG1794	racemase activity, acting on amino acids and derivatives
H4P35_12725	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H4P35_12735	COG0583	DNA-binding transcription factor activity
H4P35_12740	COG0625	glutathione transferase activity
H4P35_12745	COG2133	pyrroloquinoline quinone binding
H4P35_12755	COG0697	spore germination
H4P35_12760	COG2363	Small membrane protein
H4P35_12785	COG1414	Transcriptional regulator
H4P35_12790	COG0010	Belongs to the arginase family
H4P35_12795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4P35_12800	COG1464	Belongs to the NlpA lipoprotein family
H4P35_12810	COG1408	metallophosphoesterase
H4P35_12820	COG0688	phosphatidylethanolamine metabolic process
H4P35_12825	COG0488	(ABC) transporter
H4P35_12845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4P35_12850	COG2199	diguanylate cyclase activity
H4P35_12850	COG2200	EAL domain
H4P35_12850	COG2203	Gaf domain
H4P35_12870	COG2814	Major facilitator Superfamily
H4P35_12875	COG0784	Response regulator, receiver
H4P35_12875	COG4191	Histidine kinase
H4P35_12885	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H4P35_12910	COG2155	Conserved Protein
H4P35_12930	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_12965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4P35_12975	COG1289	transmembrane transporter activity
H4P35_12980	COG2200	EAL domain
H4P35_12980	COG2199	diguanylate cyclase activity
H4P35_12995	COG1640	4-alpha-glucanotransferase
H4P35_13000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H4P35_13010	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H4P35_13015	COG0366	Alpha amylase catalytic
H4P35_13020	COG0366	Alpha amylase catalytic
H4P35_13025	COG0297	glycogen (starch) synthase activity
H4P35_13030	COG0028	Belongs to the TPP enzyme family
H4P35_13075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4P35_13080	COG3568	Endonuclease Exonuclease Phosphatase
H4P35_13085	COG0659	secondary active sulfate transmembrane transporter activity
H4P35_13090	COG2863	cytochrome
H4P35_13110	COG1253	flavin adenine dinucleotide binding
H4P35_13120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H4P35_13145	COG1024	Enoyl-CoA hydratase
H4P35_13185	COG2199	diguanylate cyclase activity
H4P35_13200	COG0028	Belongs to the TPP enzyme family
H4P35_13210	COG2197	response regulator
H4P35_13215	COG0784	Response regulator, receiver
H4P35_13215	COG2205	protein histidine kinase activity
H4P35_13220	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H4P35_13225	COG0784	Response regulator, receiver
H4P35_13225	COG2205	protein histidine kinase activity
H4P35_13240	COG0628	permease
H4P35_13245	COG1187	pseudouridine synthase activity
H4P35_13265	COG1959	2 iron, 2 sulfur cluster binding
H4P35_13275	COG0531	amino acid
H4P35_13295	COG3119	arylsulfatase activity
H4P35_13310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4P35_13320	COG3243	poly(R)-hydroxyalkanoic acid synthase
H4P35_13330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4P35_13335	COG2197	response regulator
H4P35_13355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H4P35_13360	COG0589	response to stress
H4P35_13370	COG0589	response to stress
H4P35_13385	COG0589	response to stress
H4P35_13390	COG0431	NADPH-dependent FMN reductase
H4P35_13400	COG0798	PFAM Bile acid sodium symporter
H4P35_13405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4P35_13430	COG4993	Dehydrogenase
H4P35_13435	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4P35_13470	COG0288	reversible hydration of carbon dioxide
H4P35_13475	COG2226	methyltransferase
H4P35_13490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4P35_13500	COG3038	cytochrome b561
H4P35_13590	COG1121	(ABC) transporter
H4P35_13595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4P35_13615	COG2721	sulfolactate sulfo-lyase activity
H4P35_13655	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_13660	COG3386	PFAM SMP-30 Gluconolaconase
H4P35_13665	COG2721	sulfolactate sulfo-lyase activity
H4P35_13670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4P35_13690	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_13695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4P35_13705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_13710	COG0436	Aminotransferase
H4P35_13715	COG4597	amino acid ABC transporter
H4P35_13720	COG0765	amino acid transport
H4P35_13725	COG1126	abc transporter atp-binding protein
H4P35_13730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H4P35_13745	COG0745	RESPONSE REGULATOR receiver
H4P35_13755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4P35_13760	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H4P35_13765	COG1120	ATPase activity
H4P35_13775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4P35_13795	COG0390	transport system, permease component
H4P35_13825	COG1126	abc transporter atp-binding protein
H4P35_13830	COG0765	amino acid transport
H4P35_13835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_13865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4P35_13885	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_13890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H4P35_13895	COG0583	DNA-binding transcription factor activity
H4P35_13915	COG4191	Histidine kinase
H4P35_13920	COG4566	intracellular signal transduction
H4P35_13935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4P35_13935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4P35_13945	COG0783	Belongs to the Dps family
H4P35_13950	COG4191	Histidine kinase
H4P35_13955	COG4566	intracellular signal transduction
H4P35_13995	COG2223	nitrite transmembrane transporter activity
H4P35_14010	COG1335	isochorismatase
H4P35_14025	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_14090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4P35_14100	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_14115	COG3706	GGDEF domain
H4P35_14125	COG0384	phenazine biosynthesis protein PhzF
H4P35_14140	COG0251	oxidation-reduction process
H4P35_14165	COG0693	protein deglycase activity
H4P35_14190	COG4774	siderophore transport
H4P35_14220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4P35_14220	COG2010	Cytochrome c
H4P35_14225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4P35_14240	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4P35_14250	COG2226	methyltransferase
H4P35_14255	COG0546	phosphoglycolate phosphatase activity
H4P35_14265	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4P35_14295	COG1104	cysteine desulfurase activity
H4P35_14300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_14305	COG4597	amino acid ABC transporter
H4P35_14310	COG3154	lipid carrier protein
H4P35_14315	COG0826	peptidase U32
H4P35_14320	COG0826	peptidase U32
H4P35_14325	COG2197	response regulator
H4P35_14330	COG3850	Histidine kinase
H4P35_14335	COG1763	Mo-molybdopterin cofactor biosynthetic process
H4P35_14340	COG0288	reversible hydration of carbon dioxide
H4P35_14345	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H4P35_14350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4P35_14355	COG2181	nitrate reductase activity
H4P35_14360	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H4P35_14365	COG1140	nitrate reductase beta subunit
H4P35_14370	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H4P35_14375	COG2223	nitrite transmembrane transporter activity
H4P35_14410	COG1538	Outer membrane efflux protein
H4P35_14415	COG1566	PFAM secretion protein HlyD family protein
H4P35_14430	COG0583	DNA-binding transcription factor activity
H4P35_14465	COG1328	CTP reductase activity
H4P35_14480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4P35_14500	COG2070	2-Nitropropane dioxygenase
H4P35_14505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4P35_14525	COG0583	DNA-binding transcription factor activity
H4P35_14530	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_14540	COG1846	Transcriptional regulator
H4P35_14550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4P35_14560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H4P35_14565	COG0154	amidase activity
H4P35_14570	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_14575	COG3048	D-serine ammonia-lyase activity
H4P35_14585	COG4773	Receptor
H4P35_14615	COG2885	chlorophyll binding
H4P35_14635	COG2211	Major facilitator Superfamily
H4P35_14645	COG0438	transferase activity, transferring glycosyl groups
H4P35_14655	COG2205	protein histidine kinase activity
H4P35_14660	COG0745	RESPONSE REGULATOR receiver
H4P35_14670	COG0625	glutathione transferase activity
H4P35_14675	COG2032	superoxide dismutase activity
H4P35_14680	COG2733	membrane
H4P35_14685	COG0628	permease
H4P35_14690	COG0583	DNA-binding transcription factor activity
H4P35_14695	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4P35_14695	COG1024	Enoyl-CoA hydratase
H4P35_14700	COG0183	Belongs to the thiolase family
H4P35_14705	COG1960	acyl-CoA dehydrogenase activity
H4P35_14710	COG1960	acyl-CoA dehydrogenase activity
H4P35_14715	COG0318	PFAM AMP-dependent synthetase and ligase
H4P35_14745	COG0028	Belongs to the TPP enzyme family
H4P35_14745	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
H4P35_14780	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_14785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4P35_14790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4P35_14800	COG3706	GGDEF domain
H4P35_14800	COG4251	negative regulation of phosphorylation
H4P35_14800	COG5001	Diguanylate cyclase
H4P35_14800	COG2203	Gaf domain
H4P35_14805	COG2201	protein-glutamate methylesterase activity
H4P35_14830	COG0840	transmembrane signaling receptor activity
H4P35_14870	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H4P35_14880	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_14905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4P35_14905	COG0519	Catalyzes the synthesis of GMP from XMP
H4P35_14945	COG0583	DNA-binding transcription factor activity
H4P35_14955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4P35_14990	COG2072	flavoprotein involved in K transport
H4P35_14995	COG0601	transmembrane transport
H4P35_15000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_15005	COG0444	Belongs to the ABC transporter superfamily
H4P35_15010	COG4608	Belongs to the ABC transporter superfamily
H4P35_15015	COG0747	negative chemotaxis
H4P35_15040	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H4P35_15050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4P35_15055	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_15070	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4P35_15075	COG3971	2-oxopent-4-enoate hydratase activity
H4P35_15110	COG2130	NADP-dependent
H4P35_15115	COG0583	DNA-binding transcription factor activity
H4P35_15175	COG2353	YceI-like domain
H4P35_15200	COG0583	DNA-binding transcription factor activity
H4P35_15220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4P35_15220	COG0047	phosphoribosylformylglycinamidine synthase activity
H4P35_15230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4P35_15230	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H4P35_15235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4P35_15245	COG0613	PHP domain protein
H4P35_15255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4P35_15265	COG0583	DNA-binding transcription factor activity
H4P35_15270	COG2146	nitrite reductase [NAD(P)H] activity
H4P35_15270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4P35_15280	COG2116	formate transmembrane transporter activity
H4P35_15295	COG3707	response regulator
H4P35_15305	COG1566	PFAM secretion protein HlyD family protein
H4P35_15335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4P35_15340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4P35_15350	COG1850	ribulose-bisphosphate carboxylase activity
H4P35_15365	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H4P35_15370	COG4221	oxidoreductase activity
H4P35_15385	COG4977	sequence-specific DNA binding
H4P35_15385	COG1917	Cupin 2, conserved barrel domain protein
H4P35_15395	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_15410	COG3179	chitinase
H4P35_15425	COG0737	Belongs to the 5'-nucleotidase family
H4P35_15430	COG4604	ABC transporter, ATP-binding protein
H4P35_15435	COG4605	iron ion homeostasis
H4P35_15440	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4P35_15445	COG4607	ABC-type enterochelin transport system periplasmic component
H4P35_15450	COG4771	TonB-dependent receptor
H4P35_15455	COG0745	RESPONSE REGULATOR receiver
H4P35_15465	COG0084	hydrolase, TatD family'
H4P35_15470	COG1136	(ABC) transporter
H4P35_15485	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H4P35_15490	COG2271	Major facilitator Superfamily
H4P35_15500	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_15505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H4P35_15520	COG0183	Belongs to the thiolase family
H4P35_15525	COG1022	Amp-dependent synthetase and ligase
H4P35_15540	COG1172	Belongs to the binding-protein-dependent transport system permease family
H4P35_15565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_15575	COG0583	DNA-binding transcription factor activity
H4P35_15580	COG1803	Methylglyoxal synthase
H4P35_15585	COG2975	iron-sulfur cluster assembly
H4P35_15595	COG0443	Heat shock 70 kDa protein
H4P35_15600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H4P35_15610	COG0822	iron-sulfur transferase activity
H4P35_15615	COG1104	cysteine desulfurase activity
H4P35_15625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4P35_15630	COG0556	nucleotide-excision repair
H4P35_15640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H4P35_15645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H4P35_15650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H4P35_15655	COG0740	serine-type endopeptidase activity
H4P35_15660	COG0544	peptidyl-prolyl cis-trans isomerase activity
H4P35_15665	COG0501	Belongs to the peptidase M48B family
H4P35_15675	COG1278	Cold shock
H4P35_15685	COG1278	Cold shock
H4P35_15710	COG0251	oxidation-reduction process
H4P35_15740	COG3008	intermembrane lipid transfer
H4P35_15745	COG0456	acetyltransferase
H4P35_15755	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H4P35_15770	COG2200	EAL domain
H4P35_15785	COG2171	N-acyltransferase activity
H4P35_15790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4P35_15795	COG2890	protein-(glutamine-N5) methyltransferase activity
H4P35_15800	COG0488	(ABC) transporter
H4P35_15810	COG0210	DNA helicase
H4P35_15830	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H4P35_15835	COG0196	riboflavin kinase activity
H4P35_15840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H4P35_15845	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H4P35_15850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4P35_15915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4P35_15935	COG1902	pentaerythritol trinitrate reductase activity
H4P35_15940	COG1126	abc transporter atp-binding protein
H4P35_15945	COG0765	amino acid transport
H4P35_15950	COG0765	amino acid transport
H4P35_15955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_15965	COG1764	response to oxidative stress
H4P35_15985	COG2271	Major facilitator Superfamily
H4P35_15990	COG1802	Transcriptional regulator
H4P35_15995	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_16000	COG1024	Enoyl-CoA hydratase
H4P35_16005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_16025	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4P35_16035	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H4P35_16035	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H4P35_16035	COG0506	proline dehydrogenase activity
H4P35_16045	COG3008	intermembrane lipid transfer
H4P35_16050	COG2995	paraquat-inducible protein a
H4P35_16055	COG0542	response to heat
H4P35_16060	COG4953	penicillin-binding protein 1C
H4P35_16070	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H4P35_16075	COG1278	Cold shock
H4P35_16085	COG0183	Belongs to the thiolase family
H4P35_16090	COG0038	chloride channel
H4P35_16095	COG0840	transmembrane signaling receptor activity
H4P35_16105	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4P35_16120	COG0811	peptide transport
H4P35_16135	COG2835	tetraacyldisaccharide 4'-kinase activity
H4P35_16140	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H4P35_16145	COG0563	adenylate kinase activity
H4P35_16155	COG0728	peptidoglycan biosynthetic process
H4P35_16165	COG0268	Binds directly to 16S ribosomal RNA
H4P35_16170	COG0583	DNA-binding transcription factor activity
H4P35_16195	COG2186	Transcriptional regulator
H4P35_16205	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_16210	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_16215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4P35_16250	COG4774	siderophore transport
H4P35_16255	COG3712	iron ion homeostasis
H4P35_16260	COG1595	DNA-templated transcription, initiation
H4P35_16265	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_16270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H4P35_16275	COG1562	ergosterol biosynthetic process
H4P35_16280	COG1562	ergosterol biosynthetic process
H4P35_16290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4P35_16315	COG0583	DNA-binding transcription factor activity
H4P35_16325	COG2188	Transcriptional regulator
H4P35_16330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H4P35_16355	COG1477	protein flavinylation
H4P35_16360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4P35_16370	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H4P35_16375	COG0583	DNA-binding transcription factor activity
H4P35_16385	COG5564	TIM-barrel signal transduction protein
H4P35_16390	COG5441	Belongs to the UPF0261 family
H4P35_16405	COG0542	response to heat
H4P35_16415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4P35_16450	COG0494	nUDIX hydrolase
H4P35_16455	COG0443	Heat shock 70 kDa protein
H4P35_16465	COG3530	Putative quorum-sensing-regulated virulence factor
H4P35_16530	COG1522	sequence-specific DNA binding
H4P35_16540	COG0488	(ABC) transporter
H4P35_16560	COG3328	transposase activity
H4P35_16615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_16640	COG2951	lytic endotransglycosylase activity
H4P35_16655	COG0583	DNA-binding transcription factor activity
H4P35_16670	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_16675	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
H4P35_16695	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_16705	COG0023	Translation Initiation Factor
H4P35_16735	COG2011	ABC-type metal ion transport system permease component
H4P35_16740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4P35_16765	COG1228	amidohydrolase
H4P35_16770	COG0596	Alpha beta hydrolase
H4P35_16775	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4P35_16800	COG0840	transmembrane signaling receptor activity
H4P35_16810	COG2169	Transcriptional regulator
H4P35_16835	COG1272	protein, Hemolysin III
H4P35_16855	COG0842	Transport permease protein
H4P35_16860	COG1131	(ABC) transporter
H4P35_16875	COG0348	domain, Protein
H4P35_16895	COG3278	Belongs to the heme-copper respiratory oxidase family
H4P35_16910	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H4P35_16910	COG4106	trans-aconitate 2-methyltransferase activity
H4P35_16915	COG0583	DNA-binding transcription factor activity
H4P35_16920	COG1064	alcohol dehydrogenase
H4P35_16930	COG2224	Isocitrate lyase
H4P35_16935	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H4P35_16935	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H4P35_16940	COG1858	cytochrome C peroxidase
H4P35_16950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H4P35_16965	COG0736	holo-[acyl-carrier-protein] synthase activity
H4P35_16970	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H4P35_16980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4P35_16985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4P35_17010	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H4P35_17015	COG4149	molybdate abc transporter
H4P35_17025	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H4P35_17050	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H4P35_17055	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H4P35_17055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4P35_17060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4P35_17070	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H4P35_17075	COG4120	Belongs to the binding-protein-dependent transport system permease family
H4P35_17085	COG0667	Aldo Keto reductase
H4P35_17095	COG0318	PFAM AMP-dependent synthetase and ligase
H4P35_17100	COG1024	Enoyl-CoA hydratase
H4P35_17110	COG1802	Transcriptional regulator
H4P35_17120	COG1960	acyl-CoA dehydrogenase activity
H4P35_17125	COG1960	acyl-CoA dehydrogenase activity
H4P35_17140	COG1024	Enoyl-CoA hydratase
H4P35_17150	COG0183	Belongs to the thiolase family
H4P35_17155	COG1960	acyl-CoA dehydrogenase activity
H4P35_17165	COG0517	IMP dehydrogenase activity
H4P35_17210	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4P35_17215	COG3384	dioxygenase
H4P35_17230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H4P35_17240	COG4172	Belongs to the ABC transporter superfamily
H4P35_17245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_17250	COG0601	transmembrane transport
H4P35_17265	COG0598	Magnesium transport protein CorA
H4P35_17285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H4P35_17290	COG1012	belongs to the aldehyde dehydrogenase family
H4P35_17300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H4P35_17305	COG1045	serine acetyltransferase
H4P35_17310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4P35_17315	COG0166	Belongs to the GPI family
H4P35_17330	COG1596	polysaccharide export
H4P35_17360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4P35_17380	COG0438	transferase activity, transferring glycosyl groups
H4P35_17390	COG0110	maltose O-acetyltransferase activity
H4P35_17395	COG0297	glycogen (starch) synthase activity
H4P35_17425	COG2197	response regulator
H4P35_17430	COG2197	response regulator
H4P35_17450	COG0183	Belongs to the thiolase family
H4P35_17465	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4P35_17465	COG1024	Enoyl-CoA hydratase
H4P35_17470	COG0183	Belongs to the thiolase family
H4P35_17485	COG0318	PFAM AMP-dependent synthetase and ligase
H4P35_17500	COG3395	kinase activity
H4P35_17505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H4P35_17520	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_17525	COG1609	Transcriptional regulator
H4P35_17530	COG1595	DNA-templated transcription, initiation
H4P35_17545	COG1764	response to oxidative stress
H4P35_17565	COG2186	Transcriptional regulator
H4P35_17570	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4P35_17580	COG0318	PFAM AMP-dependent synthetase and ligase
H4P35_17585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4P35_17595	COG1024	Enoyl-CoA hydratase
H4P35_17605	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_17615	COG1414	Transcriptional regulator
H4P35_17625	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H4P35_17640	COG0583	DNA-binding transcription factor activity
H4P35_17670	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H4P35_17690	COG0825	malonyl-CoA metabolic process
H4P35_17700	COG0215	cysteine-tRNA ligase activity
H4P35_17715	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4P35_17720	COG1968	undecaprenyl-diphosphatase activity
H4P35_17725	COG1253	flavin adenine dinucleotide binding
H4P35_17740	COG4263	nitrous-oxide reductase activity
H4P35_17755	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H4P35_17770	COG0483	inositol monophosphate 1-phosphatase activity
H4P35_17790	COG0668	transmembrane transport
H4P35_17820	COG0235	Class ii aldolase
H4P35_17840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4P35_17845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4P35_17865	COG1802	Transcriptional regulator
H4P35_17885	COG3360	Dodecin
H4P35_17895	COG0583	DNA-binding transcription factor activity
H4P35_17900	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_17925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H4P35_17930	COG2850	peptidyl-arginine hydroxylation
H4P35_17940	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H4P35_17945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4P35_17950	COG1994	Peptidase M50
H4P35_17955	COG0009	L-threonylcarbamoyladenylate synthase
H4P35_17960	COG2321	neutral zinc metallopeptidase
H4P35_18010	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
H4P35_18020	COG0490	domain, Protein
H4P35_18020	COG0471	metal ion transport
H4P35_18055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4P35_18060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4P35_18070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H4P35_18080	COG4191	Histidine kinase
H4P35_18080	COG0784	Response regulator, receiver
H4P35_18085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4P35_18110	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_18125	COG3546	catalase activity
H4P35_18150	COG2192	nodulation
H4P35_18160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H4P35_18165	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_18170	COG0438	transferase activity, transferring glycosyl groups
H4P35_18175	COG5265	(ABC) transporter
H4P35_18190	COG3685	Protein conserved in bacteria
H4P35_18225	COG0668	transmembrane transport
H4P35_18235	COG0387	Pfam Sodium calcium exchanger
H4P35_18260	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
H4P35_18290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H4P35_18290	COG2755	lipolytic protein G-D-S-L family
H4P35_18305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4P35_18315	COG2084	Dehydrogenase
H4P35_18325	COG1802	Transcriptional regulator
H4P35_18340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4P35_18360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H4P35_18365	COG0519	Catalyzes the synthesis of GMP from XMP
H4P35_18365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4P35_18380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4P35_18385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H4P35_18405	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H4P35_18435	COG1228	amidohydrolase
H4P35_18440	COG2070	2-Nitropropane dioxygenase
H4P35_18450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_18455	COG1024	Enoyl-CoA hydratase
H4P35_18465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4P35_18470	COG0318	PFAM AMP-dependent synthetase and ligase
H4P35_18600	COG0740	serine-type endopeptidase activity
H4P35_18630	COG0745	RESPONSE REGULATOR receiver
H4P35_18705	COG4191	Histidine kinase
H4P35_18705	COG0784	Response regulator, receiver
H4P35_18710	COG2204	response regulator
H4P35_18715	COG1278	Cold shock
H4P35_18770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4P35_18775	COG0765	amino acid transport
H4P35_18785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_18790	COG1126	abc transporter atp-binding protein
H4P35_18795	COG1012	belongs to the aldehyde dehydrogenase family
H4P35_18810	COG2197	response regulator
H4P35_18815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4P35_18820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4P35_18825	COG1116	anion transmembrane transporter activity
H4P35_18830	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H4P35_18845	COG1396	sequence-specific DNA binding
H4P35_18860	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_18880	COG0793	Belongs to the peptidase S41A family
H4P35_18895	COG0583	DNA-binding transcription factor activity
H4P35_18900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4P35_18920	COG1473	amidohydrolase
H4P35_18935	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_18940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4P35_18950	COG1595	DNA-templated transcription, initiation
H4P35_18975	COG0384	phenazine biosynthesis protein PhzF
H4P35_18980	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H4P35_19000	COG0583	DNA-binding transcription factor activity
H4P35_19005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H4P35_19015	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4P35_19020	COG3842	ATPase activity
H4P35_19025	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H4P35_19030	COG1984	allophanate hydrolase subunit 2
H4P35_19040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4P35_19045	COG0523	cobalamin synthesis protein
H4P35_19050	COG1335	isochorismatase
H4P35_19055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H4P35_19060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4P35_19065	COG1802	Transcriptional regulator
H4P35_19070	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H4P35_19080	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_19090	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_19095	COG1024	Enoyl-CoA hydratase
H4P35_19100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_19105	COG0583	DNA-binding transcription factor activity
H4P35_19110	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_19115	COG0477	Major facilitator Superfamily
H4P35_19145	COG1126	abc transporter atp-binding protein
H4P35_19150	COG0765	amino acid transport
H4P35_19160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_19165	COG0436	Aminotransferase
H4P35_19170	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4P35_19180	COG1063	alcohol dehydrogenase
H4P35_19205	COG0071	Belongs to the small heat shock protein (HSP20) family
H4P35_19240	COG1024	Enoyl-CoA hydratase
H4P35_19250	COG1595	DNA-templated transcription, initiation
H4P35_19290	COG1546	Belongs to the CinA family
H4P35_19290	COG1058	Belongs to the CinA family
H4P35_19300	COG0500	methyltransferase
H4P35_19315	COG1201	RNA secondary structure unwinding
H4P35_19320	COG1793	dna ligase
H4P35_19325	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H4P35_19325	COG1793	dna ligase
H4P35_19345	COG1063	alcohol dehydrogenase
H4P35_19365	COG1408	metallophosphoesterase
H4P35_19380	COG0583	DNA-binding transcription factor activity
H4P35_19405	COG3448	diguanylate cyclase activity
H4P35_19405	COG4175	Glycine betaine
H4P35_19410	COG4176	ABC-type proline glycine betaine transport system permease component
H4P35_19420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4P35_19425	COG2814	Major facilitator Superfamily
H4P35_19430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H4P35_19435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H4P35_19465	COG1686	Belongs to the peptidase S11 family
H4P35_19475	COG1846	Transcriptional regulator
H4P35_19480	COG2814	Major facilitator Superfamily
H4P35_19485	COG0495	leucyl-tRNA aminoacylation
H4P35_19500	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H4P35_19515	COG0154	amidase activity
H4P35_19525	COG0477	Major facilitator Superfamily
H4P35_19540	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4P35_19555	COG0583	DNA-binding transcription factor activity
H4P35_19590	COG0583	DNA-binding transcription factor activity
H4P35_19595	COG0427	acetyl-CoA hydrolase
H4P35_19600	COG0583	DNA-binding transcription factor activity
H4P35_19605	COG3264	Mechanosensitive ion channel
H4P35_19605	COG1511	domain protein
H4P35_19660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4P35_19665	COG3958	Transketolase
H4P35_19670	COG3959	Transketolase, thiamine diphosphate binding domain
H4P35_19675	COG1802	Transcriptional regulator
H4P35_19680	COG0371	Dehydrogenase
H4P35_19690	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4P35_19695	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_19705	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4P35_19720	COG0604	alcohol dehydrogenase
H4P35_19720	COG4221	oxidoreductase activity
H4P35_19720	COG3321	synthase
H4P35_19720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4P35_19725	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_19730	COG0500	methyltransferase
H4P35_19755	COG0667	Aldo Keto reductase
H4P35_19760	COG2207	Transcriptional regulator
H4P35_19765	COG0583	DNA-binding transcription factor activity
H4P35_19770	COG1335	isochorismatase
H4P35_19850	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_19860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H4P35_19880	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H4P35_19905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4P35_19910	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H4P35_19915	COG1534	Rna-binding protein
H4P35_19920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4P35_19925	COG2233	PERMEase
H4P35_19945	COG3842	ATPase activity
H4P35_19955	COG0406	alpha-ribazole phosphatase activity
H4P35_19960	COG3547	Transposase (IS116 IS110 IS902 family)
H4P35_19970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H4P35_19975	COG0505	Belongs to the CarA family
H4P35_19980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H4P35_19995	COG0745	RESPONSE REGULATOR receiver
H4P35_20010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4P35_20020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4P35_20025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_20040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H4P35_20050	COG1074	ATP-dependent DNA helicase activity
H4P35_20075	COG1686	Belongs to the peptidase S11 family
H4P35_20090	COG1609	Transcriptional regulator
H4P35_20105	COG0277	FAD linked oxidase domain protein
H4P35_20120	COG4974	Belongs to the 'phage' integrase family
H4P35_20125	COG0583	DNA-binding transcription factor activity
H4P35_20130	COG0028	Belongs to the TPP enzyme family
H4P35_20135	COG1960	acyl-CoA dehydrogenase activity
H4P35_20165	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H4P35_20210	COG0028	Belongs to the TPP enzyme family
H4P35_20215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_20230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4P35_20235	COG1414	Transcriptional regulator
H4P35_20240	COG0009	L-threonylcarbamoyladenylate synthase
H4P35_20245	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H4P35_20250	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H4P35_20255	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H4P35_20265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H4P35_20285	COG1301	dicarboxylic acid transport
H4P35_20300	COG0583	DNA-binding transcription factor activity
H4P35_20305	COG0405	Gamma-glutamyltransferase
H4P35_20330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H4P35_20340	COG0739	heme binding
H4P35_20350	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4P35_20360	COG0306	phosphate transporter
H4P35_20400	COG0625	glutathione transferase activity
H4P35_20415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H4P35_20420	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H4P35_20430	COG0126	phosphoglycerate kinase activity
H4P35_20435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4P35_20440	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H4P35_20445	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4P35_20450	COG2732	(Barnase) inhibitor
H4P35_20460	COG0280	phosphate acetyltransferase
H4P35_20460	COG0281	malic enzyme
H4P35_20470	COG0436	Aminotransferase
H4P35_20475	COG0741	lytic transglycosylase activity
H4P35_20480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H4P35_20495	COG4575	ribosome binding
H4P35_20505	COG0243	molybdopterin cofactor binding
H4P35_20510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4P35_20515	COG1116	anion transmembrane transporter activity
H4P35_20520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4P35_20525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4P35_20535	COG1648	precorrin-2 dehydrogenase activity
H4P35_20535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H4P35_20540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H4P35_20545	COG2027	D-alanyl-D-alanine carboxypeptidase
H4P35_20550	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H4P35_20555	COG0343	queuine tRNA-ribosyltransferase activity
H4P35_20560	COG1862	Preprotein translocase
H4P35_20565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4P35_20570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4P35_20595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4P35_20600	COG1702	phosphate starvation-inducible protein PhoH
H4P35_20605	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H4P35_20610	COG4535	Mg2 and Co2 transporter CorC
H4P35_20615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H4P35_20620	COG0667	Aldo Keto reductase
H4P35_20655	COG1366	Belongs to the anti-sigma-factor antagonist family
H4P35_20655	COG2202	Pas domain
H4P35_20660	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H4P35_20665	COG0697	spore germination
H4P35_20675	COG0678	peroxiredoxin activity
H4P35_20685	COG0412	Dienelactone hydrolase
H4P35_20695	COG0315	cyclic pyranopterin monophosphate synthase activity
H4P35_20705	COG0314	molybdopterin synthase activity
H4P35_20710	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4P35_20715	COG0303	'Molybdopterin
H4P35_20720	COG0746	molybdenum cofactor guanylyltransferase activity
H4P35_20725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H4P35_20745	COG3383	formate dehydrogenase (NAD+) activity
H4P35_20750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H4P35_20760	COG2223	nitrite transmembrane transporter activity
H4P35_20780	COG2207	Transcriptional regulator
H4P35_20785	COG4221	oxidoreductase activity
H4P35_20810	COG0583	DNA-binding transcription factor activity
H4P35_20815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H4P35_20835	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_20860	COG0456	acetyltransferase
H4P35_20925	COG0671	phosphoesterase, PA-phosphatase related
H4P35_20950	COG0583	DNA-binding transcription factor activity
H4P35_20955	COG1666	GTP binding
H4P35_20960	COG1120	ATPase activity
H4P35_20965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4P35_20970	COG4558	Periplasmic binding protein
H4P35_20975	COG3720	iron ion transport
H4P35_20985	COG3712	iron ion homeostasis
H4P35_20990	COG1595	DNA-templated transcription, initiation
H4P35_21005	COG2378	regulation of single-species biofilm formation
H4P35_21015	COG1113	amino acid transport
H4P35_21025	COG1522	sequence-specific DNA binding
H4P35_21030	COG1272	protein, Hemolysin III
H4P35_21035	COG3191	aminopeptidase activity
H4P35_21040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_21045	COG0765	amino acid transport
H4P35_21050	COG1126	abc transporter atp-binding protein
H4P35_21065	COG1999	signal sequence binding
H4P35_21080	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H4P35_21090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4P35_21095	COG1845	cytochrome c oxidase, subunit III
H4P35_21165	COG4772	TonB-dependent receptor
H4P35_21185	COG0280	phosphate acetyltransferase
H4P35_21185	COG0281	malic enzyme
H4P35_21215	COG0697	spore germination
H4P35_21230	COG0583	DNA-binding transcription factor activity
H4P35_21260	COG1396	sequence-specific DNA binding
H4P35_21265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4P35_21275	COG3145	DNA-N1-methyladenine dioxygenase activity
H4P35_21280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4P35_21290	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H4P35_21295	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_21300	COG1285	pathogenesis
H4P35_21305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4P35_21320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4P35_21330	COG2706	6-phosphogluconolactonase activity
H4P35_21340	COG3712	iron ion homeostasis
H4P35_21350	COG4191	Histidine kinase
H4P35_21350	COG0784	Response regulator, receiver
H4P35_21365	COG3712	iron ion homeostasis
H4P35_21385	COG0330	HflC and HflK could
H4P35_21405	COG2807	transmembrane transport
H4P35_21410	COG2207	Transcriptional regulator
H4P35_21415	COG4106	trans-aconitate 2-methyltransferase activity
H4P35_21420	COG0861	Integral membrane protein TerC family
H4P35_21425	COG0583	DNA-binding transcription factor activity
H4P35_21470	COG0477	Major facilitator Superfamily
H4P35_21475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4P35_21480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4P35_21485	COG1845	cytochrome c oxidase, subunit III
H4P35_21490	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H4P35_21505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H4P35_21515	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H4P35_21545	COG2818	Glycosylase
H4P35_21570	COG0667	Aldo Keto reductase
H4P35_21585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4P35_21655	COG1222	aaa ATPase
H4P35_21710	COG2133	pyrroloquinoline quinone binding
H4P35_21710	COG5183	chlorophyll binding
H4P35_21725	COG5295	Hep Hag repeat protein
H4P35_21725	COG5295	Hep Hag repeat protein
H4P35_21730	COG2814	Major facilitator Superfamily
H4P35_21755	COG1116	anion transmembrane transporter activity
H4P35_21780	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4P35_21785	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H4P35_21790	COG2080	2 iron, 2 sulfur cluster binding
H4P35_21800	COG2205	protein histidine kinase activity
H4P35_21800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_21810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H4P35_21815	COG3437	response regulator, receiver
H4P35_21815	COG3850	Histidine kinase
H4P35_21815	COG2205	protein histidine kinase activity
H4P35_21815	COG4999	Histidine kinase
H4P35_21820	COG2204	response regulator
H4P35_21825	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_21830	COG2271	Major facilitator Superfamily
H4P35_21855	COG1609	Transcriptional regulator
H4P35_21875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4P35_21880	COG4251	negative regulation of phosphorylation
H4P35_21880	COG2203	Gaf domain
H4P35_21880	COG3706	GGDEF domain
H4P35_21880	COG5001	Diguanylate cyclase
H4P35_21885	COG0840	transmembrane signaling receptor activity
H4P35_21950	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H4P35_21975	COG1053	succinate dehydrogenase
H4P35_22015	COG0583	DNA-binding transcription factor activity
H4P35_22020	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_22035	COG1595	DNA-templated transcription, initiation
H4P35_22055	COG4221	oxidoreductase activity
H4P35_22075	COG0745	RESPONSE REGULATOR receiver
H4P35_22080	COG0642	Histidine kinase
H4P35_22110	COG3040	lipid binding
H4P35_22115	COG3046	protein related to deoxyribodipyrimidine photolyase
H4P35_22125	COG3038	cytochrome b561
H4P35_22170	COG1454	alcohol dehydrogenase
H4P35_22190	COG3135	benzoate transporter
H4P35_22375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4P35_22415	COG2814	Major facilitator Superfamily
H4P35_22420	COG0047	phosphoribosylformylglycinamidine synthase activity
H4P35_22435	COG0277	FAD linked oxidase domain protein
H4P35_22440	COG3119	arylsulfatase activity
H4P35_22450	COG0583	DNA-binding transcription factor activity
H4P35_22475	COG0165	Argininosuccinate lyase
H4P35_22545	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_22555	COG0604	alcohol dehydrogenase
H4P35_22575	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_22590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H4P35_22595	COG0459	protein refolding
H4P35_22610	COG0246	Mannitol dehydrogenase
H4P35_22615	COG2721	sulfolactate sulfo-lyase activity
H4P35_22625	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_22630	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4P35_22640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4P35_22645	COG2186	Transcriptional regulator
H4P35_22650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H4P35_22655	COG1252	NADH dehydrogenase
H4P35_22660	COG0284	orotidine-5'-phosphate decarboxylase activity
H4P35_22665	COG1546	Belongs to the CinA family
H4P35_22670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H4P35_22680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4P35_22685	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H4P35_22710	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H4P35_22715	COG3639	organic phosphonate transmembrane transporter activity
H4P35_22720	COG3639	organic phosphonate transmembrane transporter activity
H4P35_22735	COG0742	ribosomal rna small subunit methyltransferase
H4P35_22740	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H4P35_22745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4P35_22750	COG3135	benzoate transporter
H4P35_22765	COG2814	Major facilitator Superfamily
H4P35_22800	COG0012	GTP binding
H4P35_22830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H4P35_22835	COG0840	transmembrane signaling receptor activity
H4P35_22850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H4P35_22885	COG0204	Acyl-transferase
H4P35_22890	COG1368	sulfuric ester hydrolase activity
H4P35_22895	COG2186	Transcriptional regulator
H4P35_22900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4P35_22910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4P35_22920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H4P35_22920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4P35_22935	COG0745	RESPONSE REGULATOR receiver
H4P35_22940	COG0277	FAD linked oxidase domain protein
H4P35_22950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4P35_22955	COG0166	Belongs to the GPI family
H4P35_22960	COG0438	transferase activity, transferring glycosyl groups
H4P35_22965	COG0438	transferase activity, transferring glycosyl groups
H4P35_22970	COG0438	transferase activity, transferring glycosyl groups
H4P35_22995	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H4P35_23000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4P35_23005	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H4P35_23030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4P35_23035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4P35_23050	COG0747	negative chemotaxis
H4P35_23055	COG0601	transmembrane transport
H4P35_23060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_23065	COG4172	Belongs to the ABC transporter superfamily
H4P35_23070	COG0154	amidase activity
H4P35_23085	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4P35_23085	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4P35_23090	COG0509	glycine decarboxylation via glycine cleavage system
H4P35_23095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H4P35_23110	COG2081	HI0933 family
H4P35_23130	COG3706	GGDEF domain
H4P35_23140	COG0717	Belongs to the dCTP deaminase family
H4P35_23155	COG0489	protein tyrosine kinase activity
H4P35_23165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4P35_23165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4P35_23170	COG1054	Belongs to the UPF0176 family
H4P35_23200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4P35_23205	COG2200	EAL domain
H4P35_23220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4P35_23225	COG0842	Transport permease protein
H4P35_23225	COG1129	ABC transporter
H4P35_23230	COG0842	Transport permease protein
H4P35_23245	COG1271	oxidase subunit
H4P35_23250	COG1294	oxidase, subunit
H4P35_23260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4P35_23280	COG0431	NADPH-dependent FMN reductase
H4P35_23280	COG1053	succinate dehydrogenase
H4P35_23280	COG3976	FMN-binding domain protein
H4P35_23285	COG0583	DNA-binding transcription factor activity
H4P35_23290	COG0625	glutathione transferase activity
H4P35_23315	COG1024	Enoyl-CoA hydratase
H4P35_23325	COG1960	acyl-CoA dehydrogenase activity
H4P35_23330	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_23335	COG0583	DNA-binding transcription factor activity
H4P35_23340	COG3618	amidohydrolase
H4P35_23355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4P35_23385	COG2205	protein histidine kinase activity
H4P35_23390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4P35_23395	COG1764	response to oxidative stress
H4P35_23450	COG0411	ABC transporter
H4P35_23460	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4P35_23480	COG1131	(ABC) transporter
H4P35_23485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4P35_23490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4P35_23510	COG0583	DNA-binding transcription factor activity
H4P35_23525	COG2267	carboxylic ester hydrolase activity
H4P35_23530	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_23550	COG0840	transmembrane signaling receptor activity
H4P35_23565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4P35_23575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_23585	COG2814	Major facilitator Superfamily
H4P35_23595	COG0165	Argininosuccinate lyase
H4P35_23605	COG5002	protein histidine kinase activity
H4P35_23615	COG3275	phosphorelay sensor kinase activity
H4P35_23620	COG3279	Response regulator of the LytR AlgR family
H4P35_23635	COG3712	iron ion homeostasis
H4P35_23645	COG3246	L-lysine catabolic process to acetate
H4P35_23665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4P35_23670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4P35_23675	COG0583	DNA-binding transcription factor activity
H4P35_23685	COG1024	Enoyl-CoA hydratase
H4P35_23695	COG1960	acyl-CoA dehydrogenase activity
H4P35_23710	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_23720	COG0154	amidase activity
H4P35_23725	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_23730	COG0583	DNA-binding transcription factor activity
H4P35_23735	COG1802	Transcriptional regulator
H4P35_23740	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_23750	COG0473	3-isopropylmalate dehydrogenase activity
H4P35_23755	COG3618	amidohydrolase
H4P35_23760	COG0583	DNA-binding transcription factor activity
H4P35_23765	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_23775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4P35_23780	COG1132	(ABC) transporter
H4P35_23795	COG0583	DNA-binding transcription factor activity
H4P35_23800	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_23820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4P35_23825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4P35_23830	COG0583	DNA-binding transcription factor activity
H4P35_23835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H4P35_23850	COG1652	LysM domain
H4P35_23855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H4P35_23860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4P35_23875	COG0625	glutathione transferase activity
H4P35_23885	COG0277	FAD linked oxidase domain protein
H4P35_23890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4P35_23910	COG1012	belongs to the aldehyde dehydrogenase family
H4P35_23915	COG0583	DNA-binding transcription factor activity
H4P35_23920	COG5002	protein histidine kinase activity
H4P35_23935	COG1414	Transcriptional regulator
H4P35_23940	COG3734	2-keto-3-deoxy-galactonokinase
H4P35_23945	COG0800	Aldolase
H4P35_23950	COG4948	Mandelate Racemase Muconate Lactonizing
H4P35_23955	COG2271	Major facilitator Superfamily
H4P35_23960	COG3657	addiction module killer protein
H4P35_23970	COG2814	Major facilitator Superfamily
H4P35_23980	COG1396	sequence-specific DNA binding
H4P35_23985	COG0326	Molecular chaperone. Has ATPase activity
H4P35_23990	COG2233	PERMEase
H4P35_24015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4P35_24090	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H4P35_24130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4P35_24135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H4P35_24145	COG0583	DNA-binding transcription factor activity
H4P35_24165	COG0477	Major facilitator Superfamily
H4P35_24175	COG0583	DNA-binding transcription factor activity
H4P35_24180	COG0436	Aminotransferase
H4P35_24185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4P35_24190	COG0583	DNA-binding transcription factor activity
H4P35_24200	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H4P35_24225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_24230	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_24265	COG4638	Rieske (2fe-2S)
H4P35_24275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4P35_24280	COG3246	L-lysine catabolic process to acetate
H4P35_24290	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_24345	COG0583	DNA-binding transcription factor activity
H4P35_24355	COG1695	Transcriptional regulator
H4P35_24365	COG0477	Major facilitator Superfamily
H4P35_24380	COG0628	permease
H4P35_24385	COG0583	DNA-binding transcription factor activity
H4P35_24390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4P35_24430	COG1605	Chorismate mutase
H4P35_24430	COG0077	Prephenate dehydratase
H4P35_24440	COG2081	HI0933 family
H4P35_24445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4P35_24465	COG1129	ABC transporter
H4P35_24490	COG1126	abc transporter atp-binding protein
H4P35_24495	COG0765	amino acid transport
H4P35_24500	COG4597	amino acid ABC transporter
H4P35_24505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_24510	COG2884	Cell division ATP-binding protein ftsE
H4P35_24515	COG2177	Part of the ABC transporter FtsEX involved in
H4P35_24525	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H4P35_24530	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
H4P35_24540	COG2186	Transcriptional regulator
H4P35_24545	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_24570	COG0410	ABC transporter
H4P35_24575	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_24580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H4P35_24590	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4P35_24595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4P35_24600	COG0583	DNA-binding transcription factor activity
H4P35_24605	COG0129	dihydroxy-acid dehydratase activity
H4P35_24630	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H4P35_24635	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H4P35_24645	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4P35_24650	COG2031	fatty acid transporter
H4P35_24655	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_24660	COG1414	Transcriptional regulator
H4P35_24670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4P35_24675	COG4829	muconolactone delta-isomerase
H4P35_24685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4P35_24705	COG0288	reversible hydration of carbon dioxide
H4P35_24710	COG1802	Transcriptional regulator
H4P35_24715	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_24725	COG0559	Belongs to the binding-protein-dependent transport system permease family
H4P35_24745	COG1028	Short-chain dehydrogenase reductase Sdr
H4P35_24755	COG1053	succinate dehydrogenase
H4P35_24760	COG0625	glutathione transferase activity
H4P35_24765	COG2207	Transcriptional regulator
H4P35_24770	COG0300	oxidoreductase activity
H4P35_24785	COG0583	DNA-binding transcription factor activity
H4P35_24815	COG0318	PFAM AMP-dependent synthetase and ligase
H4P35_24830	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_24835	COG4948	Mandelate Racemase Muconate Lactonizing
H4P35_24845	COG1464	Belongs to the NlpA lipoprotein family
H4P35_24860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H4P35_24865	COG2890	protein-(glutamine-N5) methyltransferase activity
H4P35_24870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H4P35_24890	COG3171	Protein conserved in bacteria
H4P35_24905	COG3264	Mechanosensitive ion channel
H4P35_24905	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H4P35_24910	COG1522	sequence-specific DNA binding
H4P35_24920	COG5006	permease, DMT superfamily
H4P35_24930	COG3622	Belongs to the hyi family
H4P35_24945	COG0523	cobalamin synthesis protein
H4P35_24955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H4P35_24965	COG3842	ATPase activity
H4P35_24970	COG1175	transmembrane transport
H4P35_24990	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H4P35_25000	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4P35_25025	COG3866	Pectate lyase
H4P35_25030	COG1560	Kdo2-lipid A biosynthetic process
H4P35_25030	COG4783	chaperone-mediated protein folding
H4P35_25055	COG0438	transferase activity, transferring glycosyl groups
H4P35_25060	COG0457	Tetratricopeptide repeat
H4P35_25075	COG0142	geranyltranstransferase activity
H4P35_25085	COG1414	Transcriptional regulator
H4P35_25090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H4P35_25095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H4P35_25100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H4P35_25105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H4P35_25120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4P35_25125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H4P35_25135	COG2186	Transcriptional regulator
H4P35_25150	COG0793	Belongs to the peptidase S41A family
H4P35_25155	COG4942	peptidase
H4P35_25160	COG0588	phosphoglycerate mutase activity
H4P35_25165	COG1054	Belongs to the UPF0176 family
H4P35_25170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H4P35_25175	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H4P35_25180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H4P35_25190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4P35_25195	COG1040	competence protein
H4P35_25200	COG2226	methyltransferase
H4P35_25205	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H4P35_25215	COG0569	domain protein
H4P35_25220	COG2204	response regulator
H4P35_25225	COG5000	phosphorelay sensor kinase activity
H4P35_25235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H4P35_25235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4P35_25240	COG1280	lysine exporter protein (LysE YggA)
H4P35_25255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H4P35_25265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4P35_25285	COG0546	phosphoglycolate phosphatase activity
H4P35_25305	COG0242	peptide deformylase activity
H4P35_25310	COG0758	DNA mediated transformation
H4P35_25325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4P35_25330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4P35_25335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H4P35_25340	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_25345	COG0071	Belongs to the small heat shock protein (HSP20) family
H4P35_25360	COG1238	metal cluster binding
H4P35_25365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4P35_25370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H4P35_25390	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H4P35_25395	COG4988	ABC transporter
H4P35_25405	COG1294	oxidase, subunit
H4P35_25410	COG1271	oxidase subunit
H4P35_25420	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H4P35_25430	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H4P35_25445	COG1137	ATPase activity
H4P35_25450	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H4P35_25460	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H4P35_25465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4P35_25470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4P35_25470	COG2010	Cytochrome c
H4P35_25480	COG1660	Displays ATPase and GTPase activities
H4P35_25490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4P35_25505	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H4P35_25510	COG2823	Periplasmic or secreted lipoprotein
H4P35_25515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4P35_25520	COG1464	Belongs to the NlpA lipoprotein family
H4P35_25525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H4P35_25535	COG1309	transcriptional regulator
H4P35_25540	COG0471	metal ion transport
H4P35_25545	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H4P35_25555	COG0772	Belongs to the SEDS family
H4P35_25560	COG0768	penicillin binding
H4P35_25570	COG1792	Involved in formation and maintenance of cell shape
H4P35_25575	COG1077	Cell shape determining protein MreB Mrl
H4P35_25580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H4P35_25585	COG0154	amidase activity
H4P35_25590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H4P35_25605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H4P35_25610	COG0708	Exodeoxyribonuclease III
H4P35_25615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4P35_25625	COG0583	DNA-binding transcription factor activity
H4P35_25635	COG0583	DNA-binding transcription factor activity
H4P35_25660	COG3328	transposase activity
H4P35_25665	COG1764	response to oxidative stress
H4P35_25670	COG1846	Transcriptional regulator
H4P35_25725	COG0640	Transcriptional regulator
H4P35_25750	COG0297	glycogen (starch) synthase activity
H4P35_25755	COG3189	MarR family transcriptional regulator
H4P35_25760	COG0351	phosphomethylpyrimidine kinase
H4P35_25760	COG0352	thiamine-phosphate diphosphorylase activity
H4P35_25760	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H4P35_25765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H4P35_25770	COG0513	Belongs to the DEAD box helicase family
H4P35_25780	COG0617	tRNA 3'-terminal CCA addition
H4P35_25790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H4P35_25795	COG2308	Evidence 4 Homologs of previously reported genes of
H4P35_25815	COG1024	Enoyl-CoA hydratase
H4P35_25845	COG0673	inositol 2-dehydrogenase activity
H4P35_25850	COG1609	Transcriptional regulator
H4P35_25880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H4P35_25885	COG1950	PFAM Membrane protein of
H4P35_25890	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H4P35_25910	COG0066	3-isopropylmalate dehydratase activity
H4P35_25915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4P35_25920	COG3181	Tripartite tricarboxylate transporter family receptor
H4P35_25925	COG0583	DNA-binding transcription factor activity
H4P35_25930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4P35_25965	COG0477	Major facilitator Superfamily
H4P35_25970	COG0154	amidase activity
H4P35_25975	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H4P35_25985	COG1560	Kdo2-lipid A biosynthetic process
H4P35_25990	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H4P35_26000	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H4P35_26005	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
H4P35_26015	COG0803	Belongs to the bacterial solute-binding protein 9 family
H4P35_26035	COG0735	belongs to the Fur family
H4P35_26040	COG0523	cobalamin synthesis protein
H4P35_26050	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H4P35_26055	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H4P35_26065	COG2096	Adenosyltransferase
H4P35_26075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H4P35_26080	COG1609	Transcriptional regulator
H4P35_26090	COG0321	lipoyl(octanoyl) transferase activity
H4P35_26105	COG1686	Belongs to the peptidase S11 family
H4P35_26130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4P35_26140	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H4P35_26155	COG0859	PFAM glycosyl transferase family 9
H4P35_26175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4P35_26185	COG1086	Polysaccharide biosynthesis protein
H4P35_26210	COG3274	enterobacterial common antigen metabolic process
H4P35_26215	COG0438	transferase activity, transferring glycosyl groups
H4P35_26220	COG0357	Ribosomal RNA small subunit methyltransferase G
H4P35_26240	COG2814	Major facilitator Superfamily
H4P35_26245	COG0697	spore germination
H4P35_26265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4P35_26270	COG3568	Endonuclease Exonuclease Phosphatase
H4P35_26275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H4P35_26300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4P35_26315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4P35_26320	COG1956	GAF domain-containing protein
H4P35_26325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4P35_26350	COG2186	Transcriptional regulator
H4P35_26355	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H4P35_26390	COG4948	Mandelate Racemase Muconate Lactonizing
H4P35_26395	COG0583	DNA-binding transcription factor activity
H4P35_26430	COG0463	Glycosyl transferase, family 2
H4P35_26440	COG2814	Major facilitator Superfamily
H4P35_26450	COG0625	glutathione transferase activity
H4P35_26455	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H4P35_26460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H4P35_26465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H4P35_26475	COG1965	Belongs to the frataxin family
H4P35_26485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4P35_26490	COG1333	cytochrome c biogenesis protein
H4P35_26500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H4P35_26515	COG4232	protein-disulfide reductase activity
H4P35_26520	COG1324	tolerance protein
H4P35_26525	COG0537	adenosine 5'-monophosphoramidase activity
H4P35_26530	COG0203	ribosomal protein L17
H4P35_26535	COG0202	RNA polymerase activity
H4P35_26540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H4P35_26545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H4P35_26550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H4P35_26555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H4P35_26560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H4P35_26565	COG0201	protein transport
H4P35_26570	COG0200	Binds to the 23S rRNA
H4P35_26575	COG1841	ribosomal large subunit assembly
H4P35_26580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H4P35_26585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H4P35_26590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H4P35_26595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H4P35_26600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H4P35_26605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H4P35_26610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H4P35_26615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H4P35_26635	COG2207	Transcriptional regulator
H4P35_26650	COG0411	ABC transporter
H4P35_26675	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H4P35_26680	COG0255	Belongs to the universal ribosomal protein uL29 family
H4P35_26685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H4P35_26690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H4P35_26695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H4P35_26700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H4P35_26705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H4P35_26710	COG0089	rRNA binding
H4P35_26720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H4P35_26725	COG0051	transcription antitermination factor activity, RNA binding
H4P35_26730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H4P35_26735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H4P35_26740	COG0049	tRNA binding
H4P35_26745	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H4P35_26750	COG0745	RESPONSE REGULATOR receiver
H4P35_26780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H4P35_26785	COG0085	RNA polymerase activity
H4P35_26790	COG0222	ribosome binding
H4P35_26795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H4P35_26800	COG0081	regulation of translation
H4P35_26805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H4P35_26825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H4P35_26885	COG0583	DNA-binding transcription factor activity
H4P35_26890	COG0252	asparaginase activity
H4P35_26895	COG1475	DNA binding
H4P35_26905	COG1192	Involved in chromosome partitioning
H4P35_26910	COG0357	Ribosomal RNA small subunit methyltransferase G
H4P35_26915	COG0445	tRNA wobble uridine modification
H4P35_26925	COG1278	Cold shock
H4P35_26930	COG3180	Ammonia monooxygenase
H4P35_26935	COG0436	Aminotransferase
H4P35_26955	COG2205	protein histidine kinase activity
H4P35_26965	COG0038	chloride channel
H4P35_27000	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H4P35_27010	COG0601	transmembrane transport
H4P35_27015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4P35_27020	COG0444	Belongs to the ABC transporter superfamily
H4P35_27025	COG4608	Belongs to the ABC transporter superfamily
H4P35_27030	COG1473	amidohydrolase
H4P35_27035	COG2175	clavaminate synthase activity
H4P35_27045	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H4P35_27055	COG0753	catalase activity
H4P35_27060	COG0706	membrane insertase activity
H4P35_27065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H4P35_27070	COG0594	ribonuclease P activity
H4P35_27075	COG0230	Belongs to the bacterial ribosomal protein bL34 family