locus-tag class description C2U31_00015 ENOG4105D5T phosphonate abc transporter C2U31_00050 ENOG4106H78 methyltransferase C2U31_00055 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C2U31_00060 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding C2U31_00065 ENOG4105DKK Benzoate C2U31_00095 ENOG4105CPK Glycosyl transferase (Group 1 C2U31_00100 ENOG4105C3G gtp-binding protein C2U31_00120 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C2U31_00125 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C2U31_00130 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C2U31_00140 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C2U31_00145 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_00150 ENOG41081V9 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) C2U31_00160 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C2U31_00185 ENOG4105F1J Homogentisate 1,2-dioxygenase C2U31_00195 ENOG4106HNH Acyl-transferase C2U31_00200 ENOG4105E0M Sulfatase C2U31_00205 ENOG4107YCY Transcriptional regulator C2U31_00215 ENOG4108TAG Histidine kinase C2U31_00220 ENOG4105XJC Two component transcriptional regulator (Winged helix family C2U31_00225 ENOG4105CQB FAD linked oxidase domain protein C2U31_00240 ENOG4107QP8 phosphohexose isomerase C2U31_00245 ENOG4105CGN Glycosyl transferase (Group 1 C2U31_00250 ENOG4108KMV Glycosyl transferase (Group 1 C2U31_00255 ENOG4105CG5 Glycosyl transferase (Group 1 C2U31_00265 ENOG4107XU6 Glycosyl transferase (Group 1 C2U31_00280 ENOG4107QQG Dehydrogenase C2U31_00285 ENOG4107UKG Glycosyl transferase, family 4 C2U31_00290 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) C2U31_00300 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) C2U31_00305 ENOG4105BZU Histidine kinase C2U31_00315 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U31_00320 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C2U31_00325 ENOG4105C26 Dehydrogenase C2U31_00350 ENOG4108JQ6 ABC transporter C2U31_00355 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2U31_00370 ENOG4105EQR Transposase IS116 IS110 IS902 C2U31_00390 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C2U31_00395 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C2U31_00400 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C2U31_00410 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C2U31_00415 ENOG4105CBX hi0933 family C2U31_00420 ENOG4105CXN decarboxylase C2U31_00430 ENOG4108MJ3 acetyltransferase C2U31_00445 ENOG4105DHP deoxycytidine triphosphate deaminase C2U31_00475 ENOG4105C72 UPF0176 protein C2U31_00490 ENOG4105EXC Acyl-transferase C2U31_00500 ENOG4105XJC Two component transcriptional regulator (Winged helix family C2U31_00505 ENOG4107SVH Potassium channel protein C2U31_00510 ENOG4108ZVF (LipO)protein C2U31_00530 ENOG4105CXC rtn protein C2U31_00540 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class C2U31_00550 ENOG4105D0S secretion protein (HlyD C2U31_00555 ENOG4105CJ1 ABC, transporter C2U31_00560 ENOG4105CMI transporter C2U31_00570 ENOG4105CHR reductase C2U31_00575 ENOG4105EXG Transcriptional regulator C2U31_00580 ENOG4108KTG Membrane protein, drug metabolite transporter C2U31_00590 ENOG4105C4M (Ubiquinol oxidase) subunit I C2U31_00595 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C2U31_00605 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U31_00610 ENOG4105NQN cytochrome C C2U31_00620 ENOG4105CYM Glutathione S-transferase C2U31_00650 ENOG4108I0Z Aconitate hydratase C2U31_00655 ENOG4105C7F AcnD-accessory protein PrpF C2U31_00665 ENOG4105CH7 arginosuccinase C2U31_00670 ENOG4105DFA alanine racemase domain protein C2U31_00680 ENOG4107F9Y LysR family transcriptional regulator C2U31_00685 ENOG4108S8N class II Aldolase C2U31_00690 ENOG4105CSH Transporter C2U31_00700 ENOG4105CSW GntR family transcriptional regulator C2U31_00730 ENOG4106EYY C2U31_00735 ENOG4107TAE Glycosyl transferase (Group 1 C2U31_00740 ENOG4107U8J Export protein C2U31_00760 ENOG4106PQC C2U31_00765 ENOG4105DBA pectate lyase C2U31_00770 ENOG4105CR8 Transcriptional regulator C2U31_00775 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2U31_00820 ENOG4106NZI LysR family Transcriptional regulator C2U31_00825 ENOG4105C0H protease C2U31_00830 ENOG4105D0M Protease HtpX homolog C2U31_00875 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C2U31_00885 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C2U31_00890 ENOG4105VN1 Heat shock protein C2U31_00900 ENOG4105EQR Transposase IS116 IS110 IS902 C2U31_00910 ENOG4106NZI LysR family Transcriptional regulator C2U31_00925 ENOG4107QJE Chromosome Partitioning Protein C2U31_00965 ENOG4108IYH Dna topoisomerase C2U31_01105 ENOG4105F2I Transposase C2U31_01115 ENOG4108ZXE C2U31_01180 ENOG4105W5Q DNA repair protein (RadC C2U31_01215 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression C2U31_01240 ENOG4105DFP Integrase C2U31_01280 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C2U31_01290 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C2U31_01300 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C2U31_01305 ENOG4105ECQ AraC Family Transcriptional Regulator C2U31_01310 ENOG4109066 lysm domain bon superfamily protein C2U31_01315 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY C2U31_01335 ENOG4108TGY Glutathione S-transferase C2U31_01340 ENOG4107HP6 Transcriptional regulator C2U31_01345 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 C2U31_01350 ENOG4108RTU Aldolase C2U31_01355 ENOG4105CXK mandelate racemase muconate lactonizing C2U31_01360 ENOG4105DJB Major Facilitator Superfamily C2U31_01365 ENOG4105F27 Major Facilitator C2U31_01370 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) C2U31_01375 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) C2U31_01395 ENOG4105FB9 CRISPR-associated protein C2U31_01405 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C2U31_01420 ENOG4105C2W permease C2U31_01430 ENOG4105K4U addiction module toxin, RelE StbE family C2U31_01445 ENOG4108Z3N Transcriptional regulator C2U31_01450 ENOG4107QXX ABC transporter C2U31_01455 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C2U31_01485 ENOG4108IPW abc transporter atp-binding protein C2U31_01645 ENOG4105KPY Small multidrug resistance protein C2U31_01655 ENOG4106NZI LysR family Transcriptional regulator C2U31_01665 ENOG41062JF Transcriptional regulator C2U31_01690 ENOG4108YGG dna repair protein C2U31_01695 ENOG4105DFS Conserved Protein C2U31_01770 ENOG4105NTW Transcriptional regulator C2U31_01810 ENOG4105ECP epimerase C2U31_01820 ENOG4105IPI Membrane C2U31_01825 ENOG4105CBN LysR family transcriptional regulator C2U31_01830 ENOG4105ENT Efflux transporter rnd family, mfp subunit C2U31_01855 ENOG4105GP2 5'(3')-deoxyribonucleotidase C2U31_01880 ENOG4107YCY Transcriptional regulator C2U31_01890 ENOG4105E2X shikimate dehydrogenase C2U31_01900 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_01910 ENOG4105C0Z ABC transporter C2U31_01915 ENOG4108IV0 ABC, transporter C2U31_01920 ENOG4108R85 Short chain dehydrogenase C2U31_01925 ENOG4108JYK Dehydrogenase C2U31_01935 ENOG4105C7S Dehydrogenase C2U31_01940 ENOG4107QN2 dihydrolipoyl dehydrogenase C2U31_01945 ENOG4105CV8 reductase C2U31_01950 ENOG4105HEI LysR family (Transcriptional regulator C2U31_01955 ENOG4105C6T cysteine synthase C2U31_01960 ENOG4105CPC Aldo Keto reductase C2U31_01965 ENOG4107RSM transcriptional regulator C2U31_01975 ENOG4105CYM Glutathione S-transferase C2U31_01985 ENOG4105C01 Dihydroxy-acid dehydratase C2U31_01995 ENOG4105DUM transcriptional regulator, lysR family C2U31_02010 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C2U31_02015 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) C2U31_02020 ENOG4105DRR Transcriptional regulator, GntR family C2U31_02050 ENOG4105EBR Carboxylesterase C2U31_02055 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2U31_02060 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) C2U31_02070 ENOG410811B TRANSCRIPTIONal C2U31_02085 ENOG4108SF5 RNA Polymerase C2U31_02090 ENOG4108S3W Anti-feci sigma factor, fecr C2U31_02095 ENOG4105E0K tonB-dependent siderophore receptor C2U31_02105 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C2U31_02110 ENOG4105CRW Short chain fatty acid transporter C2U31_02115 ENOG4105CHR reductase C2U31_02120 ENOG4107HP6 Transcriptional regulator C2U31_02130 ENOG4107QNJ CoA-transferase subunit B C2U31_02135 ENOG4105NN7 muconolactone delta-isomerase C2U31_02145 ENOG4105F2Z 3-oxoadipate enol-lactonase C2U31_02165 ENOG4107B2H carbonic anhydrase C2U31_02210 ENOG4105CHR reductase C2U31_02220 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_02225 ENOG4105CF8 branched-chain amino acid ABC transporter, permease C2U31_02230 ENOG4105C0Z ABC transporter C2U31_02235 ENOG4108IV0 ABC, transporter C2U31_02245 ENOG4105CHR reductase C2U31_02250 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein C2U31_02255 ENOG4108U78 Glutathione S-transferase C2U31_02310 ENOG4105D01 (LipO)protein C2U31_02320 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase C2U31_02330 ENOG4108WUH Transcriptional regulator, TetR family C2U31_02335 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C2U31_02340 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C2U31_02345 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C2U31_02375 ENOG4105JQN Transcriptional regulator C2U31_02380 ENOG4105C26 Dehydrogenase C2U31_02395 ENOG4108M0I Transcriptional regulator C2U31_02405 ENOG4107GFK fumarate C2U31_02445 ENOG4107AQZ Membrane C2U31_02455 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) C2U31_02460 ENOG4105UGU tonB-dependent Receptor C2U31_02470 ENOG4105CSH Transporter C2U31_02490 ENOG4105DEF Extracellular solute-binding protein, family 5 C2U31_02495 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U31_02500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U31_02515 ENOG4105DUM transcriptional regulator, lysR family C2U31_02520 ENOG41073TP transcriptional regulator C2U31_02530 ENOG4105ZXK Dehydrogenase C2U31_02535 ENOG4105EXW epimerase dehydratase C2U31_02540 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) C2U31_02545 ENOG4105CSP Major Facilitator Superfamily C2U31_02550 ENOG4105FB2 class II Aldolase C2U31_02560 ENOG4105ECQ AraC Family Transcriptional Regulator C2U31_02565 ENOG4105DRR Transcriptional regulator, GntR family C2U31_02570 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2U31_02575 ENOG4105JN3 extra-cytoplasmic solute receptor family protein C2U31_02600 ENOG4105EAH synthase C2U31_02610 ENOG4107HP6 Transcriptional regulator C2U31_02615 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C2U31_02620 ENOG4105K46 50S ribosomal protein l27 C2U31_02625 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C2U31_02630 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C2U31_02645 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C2U31_02650 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C2U31_02670 ENOG4105D06 uba thif-type nad fad binding protein C2U31_02675 ENOG4105CN1 protease C2U31_02680 ENOG41063SB peptidase C2U31_02685 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C2U31_02690 ENOG4105C72 UPF0176 protein C2U31_02695 ENOG4105VW4 glutaredoxin 3 C2U31_02700 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) C2U31_02705 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C2U31_02720 ENOG4105MJ2 Competence protein C2U31_02725 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C2U31_02730 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) C2U31_02735 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) C2U31_02740 ENOG4105C1A potassium transporter peripheral membrane C2U31_02745 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U31_02750 ENOG4105ES5 Histidine kinase C2U31_02760 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C2U31_02765 ENOG4105E6S usher protein( C2U31_02770 ENOG4108S1B Periplasmic chaperone protein C2U31_02800 ENOG41068CG regulatoR C2U31_02805 ENOG4105BZU Histidine kinase C2U31_02810 ENOG4105BZU Histidine kinase C2U31_02840 ENOG4105KPY Small multidrug resistance protein C2U31_02845 ENOG4105KVH Transcriptional regulator C2U31_02850 ENOG4108URH decarboxylase C2U31_02860 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 C2U31_02880 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C2U31_02885 ENOG4105C79 DNA protecting protein DprA C2U31_02890 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C2U31_02900 ENOG4107QXX ABC transporter C2U31_02905 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U31_02910 ENOG4105DFA alanine racemase domain protein C2U31_02920 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C2U31_02935 ENOG4105W39 Membrane C2U31_02940 ENOG4105C7B Threonine dehydratase C2U31_02945 ENOG4108Z9W Outer membrane porin C2U31_02955 ENOG4105EXG Transcriptional regulator C2U31_02960 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) C2U31_02965 ENOG4108JJ8 (ABC) transporter C2U31_02970 ENOG4108JJ9 ABC, transporter C2U31_02980 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C2U31_02985 ENOG4105C4M (Ubiquinol oxidase) subunit I C2U31_02995 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C2U31_03000 ENOG4105C2X Arabinose 5-phosphate isomerase C2U31_03020 ENOG4108IUZ ABC transporter C2U31_03025 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA C2U31_03030 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN C2U31_03035 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) C2U31_03040 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U31_03055 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C2U31_03065 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C2U31_03080 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) C2U31_03085 ENOG4105W4M Transport-associated protein C2U31_03090 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C2U31_03095 ENOG4105D01 (LipO)protein C2U31_03100 ENOG4105CAS nag kinase C2U31_03110 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) C2U31_03115 ENOG4107QPK )-transporter C2U31_03120 ENOG4105DG4 malate L-lactate dehydrogenase C2U31_03125 ENOG4105EQR Transposase IS116 IS110 IS902 C2U31_03140 ENOG4105CNI cell division protein FtsW C2U31_03145 ENOG4105CJN penicillin-binding protein C2U31_03155 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) C2U31_03160 ENOG4105DFF Rod shape-determining protein mreb C2U31_03165 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C2U31_03170 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2U31_03175 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C2U31_03195 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C2U31_03200 ENOG4105CGK Exodeoxyribonuclease III C2U31_03205 ENOG4105D82 Glutamate dehydrogenase C2U31_03215 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) C2U31_03230 ENOG4105CP9 extracellular ligand-binding receptor C2U31_03240 ENOG4105C0Z ABC transporter C2U31_03245 ENOG4108IV0 ABC, transporter C2U31_03250 ENOG4108ZHJ Organic hydroperoxide resistance protein C2U31_03255 ENOG4105K56 Transcriptional regulator C2U31_03270 ENOG4105C0Z ABC transporter C2U31_03275 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_03290 ENOG4108IV0 ABC, transporter C2U31_03295 ENOG4105DZS Phenylacetate-CoA ligase C2U31_03300 ENOG4108VCT Sulfite exporter TauE/SafE C2U31_03320 ENOG41080HT Transcriptional regulator, arsr family C2U31_03330 ENOG4105CSR polyphosphate kinase 2 C2U31_03350 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) C2U31_03355 ENOG4105K78 MarR family Transcriptional regulator C2U31_03380 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase C2U31_03385 ENOG4105DWF phosphomethylpyrimidine kinase C2U31_03390 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C2U31_03400 ENOG4105CKT filamentous hemagglutinin C2U31_03400 ENOG4105CKT filamentous hemagglutinin C2U31_03405 ENOG4105D5K Hemolysin activator protein C2U31_03410 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C2U31_03415 ENOG4105C1J atp-dependent rna helicase C2U31_03425 ENOG4105CSH Transporter C2U31_03450 ENOG4107SC1 transglycosylase C2U31_03455 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C2U31_03480 ENOG4105SYT Methylenetetrahydrofolate reductase C2U31_03485 ENOG41086DT Membrane protein of unknown function C2U31_03490 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) C2U31_03495 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) C2U31_03515 ENOG4105CXN decarboxylase C2U31_03520 ENOG4105CPF Cell wall formation (By similarity) C2U31_03530 ENOG4105CK2 sodium dicarboxylate symporter C2U31_03540 ENOG4108IJ0 Aspartate ammonia-lyase C2U31_03545 ENOG4105EBM Alpha Beta Hydrolase Fold protein C2U31_03555 ENOG4105CSH Transporter C2U31_03560 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2U31_03565 ENOG4108Y1S CRISPR-associated protein, Csy4 family C2U31_03600 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C2U31_03615 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) C2U31_03625 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2U31_03630 ENOG4105D7X high-affinity nickel-transporter C2U31_03640 ENOG4105DSE periplasmic solute binding protein C2U31_03645 ENOG4105CC5 ABC transporter C2U31_03650 ENOG4105DIK (ABC) transporter C2U31_03655 ENOG4105MYN Zinc uptake regulation protein C2U31_03660 ENOG4105CKI cobalamin synthesis protein C2U31_03665 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters C2U31_03670 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) C2U31_03675 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) C2U31_03685 ENOG4108WBT adenosyltransferase C2U31_03695 ENOG4108RT7 Glycosyl transferase, family 2 C2U31_03700 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C2U31_03710 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase C2U31_03720 ENOG4107RGC Glycosyl transferase, family 2 C2U31_03780 ENOG4108SHN Glycosyl transferase, family 2 C2U31_03810 ENOG4105EQK -acetyltransferase C2U31_03820 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) C2U31_03835 ENOG4105P12 pyruvate phosphate dikinase C2U31_03840 ENOG41082DT Glutamine amido-transferase C2U31_03845 ENOG4108S0S Nucleotidyl transferase C2U31_03850 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C2U31_03855 ENOG4105ETE Transcriptional regulator (LacI family C2U31_03865 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) C2U31_03870 ENOG4108Z43 UPF0250 protein C2U31_03880 ENOG4105DZ1 carboxypeptidase C2U31_03915 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) C2U31_03920 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase C2U31_03925 ENOG4105D16 lipopolysaccharide heptosyltransferase i C2U31_03940 ENOG4105CMR udp-glucose 4-epimerase C2U31_03950 ENOG4105D5D udp-galactopyranose mutase C2U31_03965 ENOG4105EY8 ABC transporter C2U31_03980 ENOG4105ESV Glycosyl transferase, family 4 C2U31_03995 ENOG4107Y9U Membrane C2U31_04000 ENOG4105DZQ phospholipase D Transphosphatidylase C2U31_04005 ENOG4105X23 Endonuclease Exonuclease phosphatase C2U31_04010 ENOG4105C9M aspartyl-trna synthetase C2U31_04035 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C2U31_04050 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2U31_04060 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U31_04085 ENOG4108KWP DNA-binding transcriptional regulator GlcC C2U31_04090 ENOG4107QP3 malate synthase g C2U31_04120 ENOG4107T8Q Glycosyl transferase (Group 1 C2U31_04135 ENOG4107RDB Major Facilitator C2U31_04140 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C2U31_04150 ENOG4105DND Transcriptional regulator C2U31_04160 ENOG4105CH2 amidohydrolase C2U31_04165 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein C2U31_04170 ENOG4105D49 3-dehydroquinate synthase C2U31_04175 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C2U31_04180 ENOG4108JQC penicillin-binding protein 1A C2U31_04185 ENOG4105XQ6 frataxin-like protein C2U31_04195 ENOG4105CRE cytochrome C C2U31_04200 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) C2U31_04210 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) C2U31_04215 ENOG4105D52 delta-aminolevulinic acid dehydratase C2U31_04225 ENOG4108IV0 ABC, transporter C2U31_04230 ENOG4105C0Z ABC transporter C2U31_04240 ENOG41083Z3 extracellular ligand-binding receptor C2U31_04245 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C2U31_04250 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein C2U31_04260 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) C2U31_04265 ENOG4105VF7 tolerance protein C2U31_04275 ENOG4108ZT0 50S ribosomal protein l17 C2U31_04280 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2U31_04285 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C2U31_04290 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C2U31_04295 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C2U31_04305 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) C2U31_04310 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C2U31_04315 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C2U31_04320 ENOG4105VPB 50S ribosomal protein L30 C2U31_04325 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C2U31_04330 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C2U31_04335 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C2U31_04340 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C2U31_04345 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C2U31_04350 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits C2U31_04355 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) C2U31_04360 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C2U31_04385 ENOG4108WFR AraC Family Transcriptional Regulator C2U31_04400 ENOG4105C0Z ABC transporter C2U31_04405 ENOG4108IV0 ABC, transporter C2U31_04430 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C2U31_04435 ENOG41084PQ 50s ribosomal protein l29 C2U31_04440 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C2U31_04445 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C2U31_04450 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) C2U31_04455 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) C2U31_04460 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C2U31_04465 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) C2U31_04470 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C2U31_04475 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C2U31_04480 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C2U31_04485 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C2U31_04490 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C2U31_04495 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C2U31_04500 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C2U31_04505 ENOG4107EXC regulatoR C2U31_04535 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2U31_04540 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2U31_04545 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) C2U31_04550 ENOG4108VZM 50s ribosomal protein L10 C2U31_04555 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) C2U31_04560 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) C2U31_04570 ENOG410683Z Preprotein translocase SecE subunit C2U31_04580 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C2U31_04610 ENOG4105HDK L-asparaginase C2U31_04615 ENOG4105FA0 parb-like partition protein C2U31_04625 ENOG4107QJE Chromosome Partitioning Protein C2U31_04630 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) C2U31_04635 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C2U31_04640 ENOG4105VEQ Cold shock protein C2U31_04645 ENOG4108KK1 membrane protein AbrB duplication C2U31_04650 ENOG4105CHM Aminotransferase C2U31_04670 ENOG4105DHQ Histidine kinase C2U31_04690 ENOG4105DUM transcriptional regulator, lysR family C2U31_04695 ENOG4105E7W lamb ycsf family protein C2U31_04700 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein C2U31_04705 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C2U31_04725 ENOG4108WFR AraC Family Transcriptional Regulator C2U31_04740 ENOG4105C85 amino acid C2U31_04755 ENOG4105CHM Aminotransferase C2U31_04760 ENOG4106IPI cyclase, family C2U31_04765 ENOG4105CQB FAD linked oxidase domain protein C2U31_04770 ENOG4105CSP Major Facilitator Superfamily C2U31_04785 ENOG4105CPU Monooxygenase C2U31_04790 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) C2U31_04800 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C2U31_04820 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C2U31_04835 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U31_04840 ENOG4105C3U ABC transporter C2U31_04845 ENOG4108JQ7 (ABC) transporter C2U31_04850 ENOG4105CH2 amidohydrolase C2U31_04855 ENOG4105E2B Taurine dioxygenase C2U31_04870 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C2U31_04875 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) C2U31_04880 ENOG4105BZU Histidine kinase C2U31_04885 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C2U31_04905 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C2U31_04910 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) C2U31_04920 ENOG4105VG0 50S ribosomal protein l34 C2U31_04925 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) C2U31_04930 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C2U31_04935 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2U31_04950 ENOG4105CC0 LysR family Transcriptional regulator C2U31_04965 ENOG4105C2I pirin domain protein C2U31_04975 ENOG4105EFZ amidohydrolase C2U31_05005 ENOG4105GVF (ABC) transporter C2U31_05015 ENOG4107HP6 Transcriptional regulator C2U31_05020 ENOG4105E39 Enoyl-CoA hydratase C2U31_05030 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U31_05035 ENOG4105F38 ABC transporter, permease C2U31_05050 ENOG4105CDA abc transporter atp-binding protein C2U31_05055 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2U31_05060 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) C2U31_05085 ENOG4107RT4 flavin reductase domain protein C2U31_05090 ENOG4105RQF LysR family Transcriptional regulator C2U31_05095 ENOG4107RP9 extracellular solute-binding protein, family 3 C2U31_05100 ENOG4105EAD ABC transporter C2U31_05105 ENOG4105DRP amino acid AbC transporter C2U31_05110 ENOG4105CDA abc transporter atp-binding protein C2U31_05120 ENOG4108594 Permease of the drug metabolite transporter C2U31_05125 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 C2U31_05135 ENOG4105DMF Dehydrogenase C2U31_05150 ENOG4105DZC cytosine deaminase C2U31_05160 ENOG4105UIB (ABC) transporter C2U31_05165 ENOG4108JQ9 ABC transporter C2U31_05180 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C2U31_05195 ENOG4108MEJ flavin reductase domain protein C2U31_05205 ENOG4105CHM Aminotransferase C2U31_05210 ENOG4105CDA abc transporter atp-binding protein C2U31_05215 ENOG4105E5Q amino acid AbC transporter C2U31_05220 ENOG4105EAB amino acid AbC transporter C2U31_05240 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C2U31_05255 ENOG4107RDF Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C2U31_05265 ENOG4105FFC UPF0187 protein C2U31_05270 ENOG4108YXU transcriptional regulator AsnC family C2U31_05275 ENOG4105C7K acetolactate synthase C2U31_05280 ENOG4105CHR reductase C2U31_05285 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component C2U31_05300 ENOG4105C9U ATP-dependent DNA helicase RecQ C2U31_05310 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) C2U31_05315 ENOG4108RPN Protein smg homolog C2U31_05380 ENOG4105C8Y Acetylornithine aminotransferase C2U31_05390 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) C2U31_05425 ENOG4107U9B transcriptional regulator C2U31_05445 ENOG4108M0I Transcriptional regulator C2U31_05450 ENOG4107UWC ABC, transporter C2U31_05455 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C2U31_05480 ENOG4105E8G Major facilitator Superfamily C2U31_05495 ENOG4105J12 Multidrug resistance protein mdtN C2U31_05510 ENOG4107QX3 carboxylase C2U31_05515 ENOG4105CHU acetyl-coa acetyltransferase C2U31_05520 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) C2U31_05525 ENOG4105C1G acyl-Coa dehydrogenase C2U31_05530 ENOG4105CH2 amidohydrolase C2U31_05540 ENOG4105KK4 UPF0060 membrane protein C2U31_05555 ENOG410829K Lysine exporter protein (Lyse ygga) C2U31_05570 ENOG4105EQR Transposase IS116 IS110 IS902 C2U31_05575 ENOG4108Z33 Thiol disulfide Interchange Protein C2U31_05585 ENOG4105C75 arginyL-tRNA synthetase C2U31_05600 ENOG4108KWP DNA-binding transcriptional regulator GlcC C2U31_05605 ENOG4108Z2U ureidoglycolate hydrolase C2U31_05620 ENOG4105DRS transport system, permease C2U31_05625 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component C2U31_05630 ENOG4105BZ7 extracellular solute-binding protein family 1 C2U31_05640 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) C2U31_05645 ENOG4105ETE Transcriptional regulator (LacI family C2U31_05655 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C2U31_05670 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2U31_05685 ENOG4107RT3 EamA-like transporter family C2U31_05690 ENOG4108UQY Iron-storage protein C2U31_05700 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) C2U31_05705 ENOG410829K Lysine exporter protein (Lyse ygga) C2U31_05710 ENOG4105C1J atp-dependent rna helicase C2U31_05715 ENOG4106J39 exported protein C2U31_05720 ENOG4105CI2 imidazolone-5-propionate hydrolase C2U31_05730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U31_05735 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U31_05740 ENOG4105DEF Extracellular solute-binding protein, family 5 C2U31_05745 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C2U31_05760 ENOG410631K Membrane C2U31_05775 ENOG4105ETT transcriptional Regulator, LysR family C2U31_05790 ENOG4105KB2 stringent starvation protein b C2U31_05795 ENOG4107MKT Stringent starvation protein a C2U31_05800 ENOG4105EIX cytochrome c1 C2U31_05805 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C2U31_05810 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C2U31_05815 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) C2U31_05820 ENOG4108S8N class II Aldolase C2U31_05830 ENOG4105CSH Transporter C2U31_05840 ENOG4107QNR UPF0135 protein C2U31_05845 ENOG4105C0H protease C2U31_05860 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) C2U31_05865 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C2U31_05870 ENOG4107YU2 histidine triad (hIT) protein C2U31_05875 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase C2U31_05880 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C2U31_05885 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C2U31_05890 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C2U31_05895 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C2U31_05900 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C2U31_05905 ENOG4105CIH Imidazole acetol-phosphate transaminase C2U31_05910 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C2U31_05915 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C2U31_05920 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C2U31_05930 ENOG4105E3A (ABC) transporter C2U31_05935 ENOG4105DA5 (ABC) transporter C2U31_05945 ENOG410903C (LipO)protein C2U31_05950 ENOG4107PE3 Mammalian cell entry related domain protein C2U31_05955 ENOG4105CY3 ABC transporter, permease C2U31_05960 ENOG4105DHJ ABC, transporter C2U31_05975 ENOG4105CBP Major Facilitator C2U31_05980 ENOG4105EGI Transcriptional regulator C2U31_05985 ENOG4105EIF outer membrane protein W C2U31_06015 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2U31_06020 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) C2U31_06035 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) C2U31_06040 ENOG4105BZ9 Cytochrome C oxidase, subunit I C2U31_06050 ENOG4107QS1 Cytochrome C Oxidase, Subunit III C2U31_06070 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) C2U31_06075 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C2U31_06100 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C2U31_06105 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2U31_06110 ENOG4105C6Y Udp-glucose 6-dehydrogenase C2U31_06130 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C2U31_06145 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C2U31_06165 ENOG41088CQ domain protein C2U31_06170 ENOG4105FBW Monooxygenase C2U31_06175 ENOG4108J59 Extracellular solute-binding protein, family 5 C2U31_06185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U31_06190 ENOG4108JQ6 ABC transporter C2U31_06200 ENOG4105CPC Aldo Keto reductase C2U31_06250 ENOG4105KME endoribonuclease L-psp C2U31_06255 ENOG4105FC8 fad dependent oxidoreductase C2U31_06260 ENOG4105IH7 synthase C2U31_06265 ENOG4106B0W Curli production assembly transport component CsgG C2U31_06275 ENOG4107Y60 (LipO)protein C2U31_06310 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_06325 ENOG4105C85 amino acid C2U31_06335 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C2U31_06340 ENOG4107NQ8 LysR family Transcriptional regulator C2U31_06345 ENOG4105CK7 Sodium proline symporter C2U31_06350 ENOG4105CYW agmatinase C2U31_06355 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C2U31_06400 ENOG4105CGH 5'-nucleotidase C2U31_06415 ENOG4105CZE histidine utilization repressor C2U31_06420 ENOG41090B9 response to stress C2U31_06430 ENOG4105ETS cytosine purines uracil thiamine allantoin C2U31_06440 ENOG4105C85 amino acid C2U31_06445 ENOG4105CI2 imidazolone-5-propionate hydrolase C2U31_06450 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_06530 ENOG4105D01 (LipO)protein C2U31_06535 ENOG4108UZX fmn reductase C2U31_06540 ENOG4105GVF (ABC) transporter C2U31_06545 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) C2U31_06550 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C2U31_06555 ENOG4107T8P acyl-Coa dehydrogenase C2U31_06560 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2U31_06565 ENOG4108UMI ABC transporter, permease C2U31_06570 ENOG4105D01 (LipO)protein C2U31_06575 ENOG4105E2Y ABC, transporter C2U31_06580 ENOG4105X1Q TOBE domain protein C2U31_06605 ENOG4105CBG Sulfatase C2U31_06610 ENOG4107RSM transcriptional regulator C2U31_06625 ENOG4105CSH Transporter C2U31_06630 ENOG4105CHR reductase C2U31_06635 ENOG4105F76 Sarcosine oxidase C2U31_06640 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) C2U31_06645 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) C2U31_06650 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein C2U31_06655 ENOG4108MG3 formate dehydrogenase C2U31_06660 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) C2U31_06670 ENOG4105EM7 Selenocysteine-specific translation elongation factor C2U31_06680 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C2U31_06685 ENOG4108KS2 transglutaminase domain protein C2U31_06700 ENOG4105ETT transcriptional Regulator, LysR family C2U31_06720 ENOG4105C26 Dehydrogenase C2U31_06725 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C2U31_06730 ENOG4105DK0 Indole-3-glycerol phosphate synthase C2U31_06735 ENOG4107QYG anthranilate phosphoribosyltransferase C2U31_06740 ENOG4105DDQ anthranilate synthase C2U31_06750 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C2U31_06760 ENOG4105NWN ApaG protein C2U31_06765 ENOG4105CA3 membrane-bound lytic murein transglycosylase C2U31_06770 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family C2U31_06775 ENOG4105T95 Thiol disulfide interChange protein C2U31_06785 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) C2U31_06805 ENOG4106NZI LysR family Transcriptional regulator C2U31_06815 ENOG4105E39 Enoyl-CoA hydratase C2U31_06830 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) C2U31_06835 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C2U31_06840 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C2U31_06845 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C2U31_06850 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C2U31_06855 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C2U31_06860 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C2U31_06865 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C2U31_06875 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C2U31_06880 ENOG4105C25 Primosomal protein n' C2U31_06885 ENOG4105C4R Atp-dependent dna helicase C2U31_06890 ENOG4105E7U AraC family transcriptional regulator C2U31_06900 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C2U31_06905 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) C2U31_06910 ENOG4105MZG transcriptional modulator of maze toxin, mazf C2U31_06920 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C2U31_06930 ENOG4108JQ7 (ABC) transporter C2U31_06935 ENOG4105C3U ABC transporter C2U31_06940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U31_06945 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U31_06950 ENOG4105DEF Extracellular solute-binding protein, family 5 C2U31_06955 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) C2U31_06965 ENOG4105EMY transcriptional regulator C2U31_06970 ENOG4105DEF Extracellular solute-binding protein, family 5 C2U31_06980 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) C2U31_06985 ENOG41060WC Enoyl-CoA hydratase C2U31_07000 ENOG4105KBX Transcriptional regulator, TetR family C2U31_07015 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C2U31_07035 ENOG4105BZU Histidine kinase C2U31_07055 ENOG4105ERH Fumarylacetoacetate hydrolase C2U31_07065 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_07070 ENOG4105CF8 branched-chain amino acid ABC transporter, permease C2U31_07075 ENOG4105C2J ABC transporter C2U31_07080 ENOG4108IV0 ABC, transporter C2U31_07090 ENOG4107XBN GntR Family Transcriptional Regulator C2U31_07110 ENOG4105D9M gamma-glutamylcysteine synthetase C2U31_07125 ENOG4105VJY transcriptional regulator C2U31_07135 ENOG4105DG4 malate L-lactate dehydrogenase C2U31_07140 ENOG4108JQ1 Dehydrogenase C2U31_07150 ENOG4105CTX dehydratase C2U31_07155 ENOG4105VP7 SAF domain protein C2U31_07160 ENOG4105FDP GntR family transcriptional regulator C2U31_07165 ENOG4105DWV Homoserine O-trans-acetylase C2U31_07170 ENOG4105DWV Homoserine O-trans-acetylase C2U31_07175 ENOG4105EYM Major Facilitator superfamily C2U31_07185 ENOG4105EN6 Membrane C2U31_07190 ENOG4105DRR Transcriptional regulator, GntR family C2U31_07195 ENOG4105E7W lamb ycsf family protein C2U31_07205 ENOG4105P4J Allophanate hydrolase, subunit 1 C2U31_07215 ENOG4105DUM transcriptional regulator, lysR family C2U31_07220 ENOG4108JQ1 Dehydrogenase C2U31_07235 ENOG4105E3B Multicopper oxidase C2U31_07240 ENOG4105UTB Blue (Type 1) copper domain protein C2U31_07245 ENOG4105GR3 Histidine kinase C2U31_07255 ENOG4105BZU Histidine kinase C2U31_07260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2U31_07265 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C2U31_07280 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) C2U31_07290 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) C2U31_07300 ENOG4105DFG type I secretion outer membrane protein C2U31_07305 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) C2U31_07310 ENOG4105DWF phosphomethylpyrimidine kinase C2U31_07315 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C2U31_07320 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C2U31_07325 ENOG4105D05 Receptor C2U31_07330 ENOG4105C3R Methionine synthase C2U31_07340 ENOG4107YCY Transcriptional regulator C2U31_07350 ENOG4105CRP Part of the ABC transporter FtsEX involved in C2U31_07355 ENOG4105CAK Cell division ATP-binding protein ftsE C2U31_07360 ENOG4107QXX ABC transporter C2U31_07365 ENOG4105EZ7 amino acid ABC transporter C2U31_07370 ENOG4105DRP amino acid AbC transporter C2U31_07375 ENOG4105CDA abc transporter atp-binding protein C2U31_07385 ENOG4105ENT Efflux transporter rnd family, mfp subunit C2U31_07390 ENOG4105BZS acriflavin resistance protein C2U31_07410 ENOG4105MSY salicylate hydroxylase C2U31_07415 ENOG4105CBX hi0933 family C2U31_07420 ENOG4105JN3 extra-cytoplasmic solute receptor family protein C2U31_07425 ENOG4105CQC Prephenate dehydratase C2U31_07455 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C2U31_07460 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2U31_07470 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) C2U31_07475 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) C2U31_07480 ENOG4108ZXC Two component transcriptional regulator, luxr family C2U31_07495 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C2U31_07500 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) C2U31_07510 ENOG4105BZS acriflavin resistance protein C2U31_07515 ENOG4105BZS acriflavin resistance protein C2U31_07520 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C2U31_07525 ENOG4105CHR reductase C2U31_07530 ENOG4105CBN LysR family transcriptional regulator C2U31_07540 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2U31_07550 ENOG4105RQF LysR family Transcriptional regulator C2U31_07560 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_07565 ENOG4105C0Z ABC transporter C2U31_07570 ENOG4108IV0 ABC, transporter C2U31_07580 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A C2U31_07600 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) C2U31_07620 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_07625 ENOG4105CF8 branched-chain amino acid ABC transporter, permease C2U31_07630 ENOG4105C2J ABC transporter C2U31_07635 ENOG4108IV0 ABC, transporter C2U31_07655 ENOG4105BZU Histidine kinase C2U31_07660 ENOG4105BZU Histidine kinase C2U31_07675 ENOG4108UKI Enoyl-CoA hydratase C2U31_07715 ENOG4105FUY alpha subunit C2U31_07720 ENOG4108UKV benzoate 1,2-dioxygenase C2U31_07725 ENOG4105D3W isochorismatase C2U31_07730 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C2U31_07740 ENOG4105E4C Lytic transglycosylase catalytic C2U31_07745 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C2U31_07760 ENOG4105VCQ rubredoxin C2U31_07765 ENOG4108UJU UPF0301 protein C2U31_07770 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C2U31_07780 ENOG4105CD3 dihydroorotase C2U31_07785 ENOG4108Z20 Acyl-transferase C2U31_07795 ENOG4105JSC dimethylmenaquinone methyltransferase C2U31_07800 ENOG4105CHM Aminotransferase C2U31_07805 ENOG4108HW3 (ABC) transporter C2U31_07810 ENOG4105E5Q amino acid AbC transporter C2U31_07815 ENOG4105DRP amino acid AbC transporter C2U31_07820 ENOG4105CDA abc transporter atp-binding protein C2U31_07825 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) C2U31_07835 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase C2U31_07840 ENOG4105E2X shikimate dehydrogenase C2U31_07850 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U31_07855 ENOG4107Z33 ABC transporter, permease C2U31_07875 ENOG41062D9 Histidine kinase C2U31_07890 ENOG4105IPS esterase C2U31_07895 ENOG4105DFU Cell wall formation (By similarity) C2U31_07900 ENOG4107QX9 Thiol disulfide interChange protein C2U31_07905 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C2U31_07910 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein C2U31_07915 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C2U31_07920 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C2U31_07955 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C2U31_07975 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2U31_07980 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2U31_07990 ENOG4105J0Q Transcriptional regulator C2U31_08010 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C2U31_08015 ENOG4105CD5 CoA-binding domain protein C2U31_08025 ENOG4105N42 UPF0307 protein C2U31_08030 ENOG4105CMS peptidase U62, modulator of DNA gyrase C2U31_08035 ENOG4105CH5 extracellular solute-binding protein, family 7 C2U31_08045 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_08050 ENOG4105CF8 branched-chain amino acid ABC transporter, permease C2U31_08055 ENOG4105C0Z ABC transporter C2U31_08060 ENOG4108IV0 ABC, transporter C2U31_08065 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C2U31_08070 ENOG4108UJD 30S ribosomal protein S9 C2U31_08075 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C2U31_08085 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C2U31_08090 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) C2U31_08100 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C2U31_08105 ENOG4108V1U phospholipid-binding protein C2U31_08110 ENOG4105N14 lysine exporter protein LysE YggA C2U31_08115 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C2U31_08120 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) C2U31_08130 ENOG4108RWI nicotinamidase C2U31_08135 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C2U31_08150 ENOG4105CYN Serine protein kinase C2U31_08155 ENOG4106AKX UPF0229 protein C2U31_08160 ENOG4105ED1 spovr family C2U31_08190 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C2U31_08200 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C2U31_08205 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C2U31_08225 ENOG4105CHR reductase C2U31_08260 ENOG4105EA8 2-Nitropropane dioxygenase C2U31_08280 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_08300 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C2U31_08305 ENOG4105E9H Lytic Murein transglycosylase C2U31_08310 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) C2U31_08315 ENOG4105D1A Methyltransferase C2U31_08320 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C2U31_08330 ENOG4105BZS acriflavin resistance protein C2U31_08335 ENOG4107RZZ dna polymerase iii epsilon subunit C2U31_08350 ENOG4108UPT UPF0178 protein C2U31_08365 ENOG4105D6U Sodium Glutamate Symporter C2U31_08380 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) C2U31_08395 ENOG4105CR8 Transcriptional regulator C2U31_08410 ENOG4105CMU LysR family (Transcriptional regulator C2U31_08415 ENOG4105VAW lrga family C2U31_08420 ENOG41067MG lrgb family C2U31_08430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U31_08445 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C2U31_08455 ENOG4108YXU transcriptional regulator AsnC family C2U31_08460 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) C2U31_08470 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) C2U31_08475 ENOG4105EHG Permease protein C2U31_08485 ENOG4105KCK Peptidoglycan-associated lipoprotein C2U31_08490 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) C2U31_08500 ENOG4105M8F Biopolymer transport protein exbD tolR C2U31_08505 ENOG4105E02 MotA TolQ exbB proton channel C2U31_08510 ENOG4107YD3 Thioesterase C2U31_08515 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C2U31_08540 ENOG4105F38 ABC transporter, permease C2U31_08550 ENOG4105CNV Aldolase C2U31_08560 ENOG4105JSC dimethylmenaquinone methyltransferase C2U31_08565 ENOG4105DND Transcriptional regulator C2U31_08585 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase C2U31_08590 ENOG4105EXG Transcriptional regulator C2U31_08595 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C2U31_08600 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C2U31_08605 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C2U31_08645 ENOG4105C01 Dihydroxy-acid dehydratase C2U31_08650 ENOG4105W2Z cytochrome C, class I C2U31_08655 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C2U31_08665 ENOG4105EW9 transcriptional regulator AsnC family C2U31_08705 ENOG4105CH2 amidohydrolase C2U31_08710 ENOG4105EKE dihydroorotase C2U31_08715 ENOG4105C5H ABC transporter C2U31_08725 ENOG4108V6E Cell division protein mraZ C2U31_08730 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C2U31_08735 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) C2U31_08740 ENOG4105CJN penicillin-binding protein C2U31_08745 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C2U31_08750 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C2U31_08755 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C2U31_08765 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C2U31_08770 ENOG4105DFU Cell wall formation (By similarity) C2U31_08775 ENOG4105CPF Cell wall formation (By similarity) C2U31_08780 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) C2U31_08785 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C2U31_08790 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C2U31_08795 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C2U31_08805 ENOG4105DR5 peptidase C2U31_08810 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C2U31_08830 ENOG4105C7K acetolactate synthase C2U31_08845 ENOG4105MWK D-amino acid dehydrogenase, small subunit C2U31_08850 ENOG4108XM1 transcriptional regulator AsnC family C2U31_08865 ENOG4105CJW magnesium transporter C2U31_08870 ENOG4105NAU thioesterase Superfamily protein C2U31_08875 ENOG4105HMI Membrane C2U31_08880 ENOG4105DUM transcriptional regulator, lysR family C2U31_08885 ENOG4105CH2 amidohydrolase C2U31_08890 ENOG4105CEY Amp-dependent synthetase and ligase C2U31_08895 ENOG4105ECY inositol monophosphatase C2U31_08900 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) C2U31_08905 ENOG4105CJQ hydrolase, family 31 C2U31_08910 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2U31_08915 ENOG4108UMI ABC transporter, permease C2U31_08920 ENOG4105D01 (LipO)protein C2U31_08940 ENOG41090R7 Ferric uptake C2U31_08960 ENOG4108R3E Dna-3-methyladenine glycosylase i C2U31_08965 ENOG4105E0M Sulfatase C2U31_08970 ENOG41066T0 asmA family C2U31_08975 ENOG4105BZU Histidine kinase C2U31_08980 ENOG4108IND Tetr family transcriptional regulator C2U31_08985 ENOG4105F6U Short-chain dehydrogenase reductase Sdr C2U31_08995 ENOG4105CSR polyphosphate kinase 2 C2U31_09005 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C2U31_09020 ENOG4105KZX Pterin carbinolamine dehydratase C2U31_09030 ENOG4108S0S Nucleotidyl transferase C2U31_09035 ENOG4105EHM Aminoglycoside phosphotransferase C2U31_09040 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) C2U31_09045 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) C2U31_09050 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C2U31_09055 ENOG4105BZW Glycerate kinase C2U31_09060 ENOG4105CA9 Pyruvate kinase C2U31_09070 ENOG4107QPN acyl-Coa dehydrogenase C2U31_09075 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C2U31_09095 ENOG4105E9Q Acyl-transferase C2U31_09100 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase C2U31_09105 ENOG4105C38 Glycyl-tRNA synthetase beta subunit C2U31_09110 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit C2U31_09130 ENOG410900P UPF0336 protein C2U31_09135 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr C2U31_09140 ENOG4105DUM transcriptional regulator, lysR family C2U31_09155 ENOG4105CEY Amp-dependent synthetase and ligase C2U31_09160 ENOG4105CHU acetyl-coa acetyltransferase C2U31_09170 ENOG4105CC9 acyl-Coa dehydrogenase C2U31_09175 ENOG4105C1G acyl-Coa dehydrogenase C2U31_09180 ENOG4108UKI Enoyl-CoA hydratase C2U31_09190 ENOG4108M9J MaoC like domain protein C2U31_09205 ENOG4108IYU L-aspartate oxidase C2U31_09215 ENOG4108MGF sugar kinase C2U31_09220 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C2U31_09225 ENOG4105DJ0 Poly(A) Polymerase C2U31_09235 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) C2U31_09240 ENOG4105CXB phosphoribosylaminoimidazole synthetase C2U31_09245 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C2U31_09250 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C2U31_09255 ENOG4105DQR SNARE associated Golgi C2U31_09260 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C2U31_09265 ENOG4105K8N protein family UPF0079, ATPase C2U31_09270 ENOG4105C9Q fumarate hydratase class II C2U31_09290 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C2U31_09295 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C2U31_09305 ENOG4105CSU acyl-Coa dehydrogenase C2U31_09310 ENOG4106NZI LysR family Transcriptional regulator C2U31_09320 ENOG4105D5U fad dependent oxidoreductase C2U31_09330 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) C2U31_09345 ENOG4105DJY efflux transporter, rnd family, mfp subunit C2U31_09350 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C2U31_09355 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C2U31_09360 ENOG4105CUZ uba thif-type nad fad binding protein C2U31_09405 ENOG41082YX Transcriptional regulator, arsr family C2U31_09420 ENOG4105K5X acetyltransferase C2U31_09425 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C2U31_09450 ENOG4105WH1 Two component transcriptional regulator luxr family C2U31_09485 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C2U31_09490 ENOG410624X efflux transporter, rnd family, mfp subunit C2U31_09505 ENOG4105F04 LysR family Transcriptional regulator C2U31_09510 ENOG4105C26 Dehydrogenase C2U31_09515 ENOG4108IGT Dipeptidase C2U31_09530 ENOG4105CRQ synthase (Component I) C2U31_09535 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C2U31_09545 ENOG4108UHU Aldolase C2U31_09555 ENOG4105CR8 Transcriptional regulator C2U31_09560 ENOG4105K64 Glycosyl transferase, family 2 C2U31_09565 ENOG4108IV0 ABC, transporter C2U31_09570 ENOG4105C0Z ABC transporter C2U31_09585 ENOG4105CHR reductase C2U31_09590 ENOG4106IPI cyclase, family C2U31_09605 ENOG4105CEY Amp-dependent synthetase and ligase C2U31_09610 ENOG4108UKV benzoate 1,2-dioxygenase C2U31_09615 ENOG4105FUY alpha subunit C2U31_09640 ENOG4105DEF Extracellular solute-binding protein, family 5 C2U31_09645 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U31_09650 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U31_09655 ENOG4105C3U ABC transporter C2U31_09660 ENOG4108JQ7 (ABC) transporter C2U31_09680 ENOG4105C5H ABC transporter C2U31_09700 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) C2U31_09705 ENOG4107QMS site-determining protein C2U31_09710 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) C2U31_09715 ENOG4105CX6 glutaminyL-tRNA synthetase C2U31_09720 ENOG4105C4M (Ubiquinol oxidase) subunit I C2U31_09725 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C2U31_09730 ENOG4105C9U ATP-dependent DNA helicase RecQ C2U31_09740 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2U31_09750 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C2U31_09765 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C2U31_09770 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) C2U31_09785 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C2U31_09790 ENOG4105D0A hydroxylase C2U31_09800 ENOG4107RAQ aminopeptidase C2U31_09815 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic C2U31_09835 ENOG4105ERG peptidase m48, ste24p C2U31_09855 ENOG4105CM2 brancheD-chain amino acid aminotransferase C2U31_09870 ENOG4105C1J atp-dependent rna helicase C2U31_09890 ENOG41069M3 Transcriptional regulator C2U31_09905 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) C2U31_09910 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate C2U31_09915 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) C2U31_09920 ENOG4105E09 nadh pyrophosphatase C2U31_09925 ENOG4105CC0 LysR family Transcriptional regulator C2U31_09960 ENOG4107E2E PKHD-type hydroxylase C2U31_09965 ENOG4108ESX Receptor C2U31_09975 ENOG4105CTX dehydratase C2U31_09980 ENOG4105CT1 (ABC) transporter C2U31_09990 ENOG4105EZ7 amino acid ABC transporter C2U31_09995 ENOG4105DRP amino acid AbC transporter C2U31_10000 ENOG4105DRR Transcriptional regulator, GntR family C2U31_10015 ENOG4107QJE Chromosome Partitioning Protein C2U31_10050 ENOG4107YH6 single-stranded DNA-binding protein C2U31_10055 ENOG4108IYH Dna topoisomerase C2U31_10060 ENOG4105NI8 Cytosine-specific methyltransferase C2U31_10110 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C2U31_10295 ENOG4105W5Q DNA repair protein (RadC C2U31_10380 ENOG4108MZY C2U31_10385 ENOG4108MR5 C2U31_10390 ENOG4105DKK Benzoate C2U31_10420 ENOG4105F2Z 3-oxoadipate enol-lactonase C2U31_10425 ENOG4105CHU acetyl-coa acetyltransferase C2U31_10430 ENOG4107QNJ CoA-transferase subunit B C2U31_10440 ENOG4105D2S major facilitator superfamily C2U31_10450 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase C2U31_10470 ENOG410626B catechol 1,2-dioxygenase C2U31_10495 ENOG4105F27 Major Facilitator C2U31_10500 ENOG4108M8W Monooxygenase C2U31_10510 ENOG4105ECR NmrA family C2U31_10515 ENOG4105KVH Transcriptional regulator C2U31_10520 ENOG4105EQ0 Major Facilitator superfamily C2U31_10525 ENOG4106KE4 Dehydrogenase C2U31_10530 ENOG4108IND Tetr family transcriptional regulator C2U31_10560 ENOG4105PY6 Phenolic acid decarboxylase C2U31_10565 ENOG4108W5M transcriptional regulator C2U31_10570 ENOG4105CB2 alcohol dehydrogenase C2U31_10580 ENOG4105CS1 NAD(P)H quinone oxidoreductase C2U31_10585 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr C2U31_10595 ENOG4105F27 Major Facilitator C2U31_10605 ENOG4106NZI LysR family Transcriptional regulator C2U31_10620 ENOG4105DFP Integrase C2U31_10630 ENOG4108VKM cytochrome b561 C2U31_10635 ENOG4108VAU general secretion pathway protein G C2U31_10645 ENOG4105D7Q type ii secretion system C2U31_10650 ENOG4107QHF type ii secretion system protein e C2U31_10675 ENOG4105GVR general secretion pathway protein D C2U31_10680 ENOG4108VAU general secretion pathway protein G C2U31_10685 ENOG4108VAU general secretion pathway protein G C2U31_10695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2U31_10700 ENOG4105BZU Histidine kinase C2U31_10710 ENOG4105D2S major facilitator superfamily C2U31_10715 ENOG4105HDK L-asparaginase C2U31_10735 ENOG4105CHR reductase C2U31_10745 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C2U31_10780 ENOG4107QJE Chromosome Partitioning Protein C2U31_10840 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C2U31_10880 ENOG4105BZU Histidine kinase C2U31_11090 ENOG4105DTA methyltransferase C2U31_11095 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C2U31_11100 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class C2U31_11105 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C2U31_11120 ENOG4105CHU acetyl-coa acetyltransferase C2U31_11125 ENOG4105CHR reductase C2U31_11135 ENOG4105CMI transporter C2U31_11140 ENOG4105CJ1 ABC, transporter C2U31_11150 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C2U31_11165 ENOG4106NZI LysR family Transcriptional regulator C2U31_11195 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C2U31_11200 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) C2U31_11205 ENOG41090R7 Ferric uptake C2U31_11210 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C2U31_11215 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C2U31_11220 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) C2U31_11225 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C2U31_11235 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C2U31_11245 ENOG4105CFG Acts as a chaperone (By similarity) C2U31_11250 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C2U31_11265 ENOG4108YYQ gCN5-related N-acetyltransferase C2U31_11275 ENOG4108Z7F N-acetyltransferase C2U31_11285 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C2U31_11295 ENOG4106RE7 Cytochrome C2U31_11320 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_11325 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2U31_11340 ENOG4105EEX Two component transcriptional regulator (Winged helix family C2U31_11345 ENOG4105C08 Histidine kinase C2U31_11350 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) C2U31_11355 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C2U31_11375 ENOG4107QN1 sodium solute C2U31_11385 ENOG4105C98 muts2 protein C2U31_11390 ENOG4105C3M thioredoxin reductase C2U31_11395 ENOG4105CNU cell division protein FtsK C2U31_11400 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) C2U31_11405 ENOG4105KME endoribonuclease L-psp C2U31_11415 ENOG4105C2X Arabinose 5-phosphate isomerase C2U31_11450 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C2U31_11460 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C2U31_11470 ENOG4105D1H recombination factor protein RarA C2U31_11490 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C2U31_11530 ENOG41066DG (EAL) domain protein C2U31_11535 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_11540 ENOG4105JJR Histidine kinase C2U31_11550 ENOG4105EQR Transposase IS116 IS110 IS902 C2U31_11560 ENOG4105DFG type I secretion outer membrane protein C2U31_11565 ENOG4105C42 Type I secretion membrane fusion protein (HlyD C2U31_11570 ENOG4108JJA ABC, transporter C2U31_11585 ENOG4105DTD Dehydrogenase C2U31_11590 ENOG4105D1Q UPF0246 protein C2U31_11600 ENOG4105C7K acetolactate synthase C2U31_11605 ENOG4108ZP8 Acetolactate synthase small subunit C2U31_11610 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C2U31_11615 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C2U31_11625 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C2U31_11630 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C2U31_11645 ENOG41080HI glycine oxidase C2U31_11675 ENOG4105E1V na solute symporter C2U31_11690 ENOG4105C7B Threonine dehydratase C2U31_11700 ENOG4105CW0 outer membrane usher protein C2U31_11705 ENOG4108VCD Chaperone C2U31_11725 ENOG4105ES4 Nitrilase C2U31_11735 ENOG41068CG regulatoR C2U31_11755 ENOG4108PZW LysR family Transcriptional regulator C2U31_11765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2U31_11790 ENOG4105CP7 Triose-phosphate isomerase C2U31_11840 ENOG4105E6M Sulphatase-modifying factor protein C2U31_11880 ENOG41082W1 Cupin 2, conserved barrel domain protein C2U31_11890 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C2U31_11900 ENOG4105ETT transcriptional Regulator, LysR family C2U31_11905 ENOG410620I Diguanylate cyclase C2U31_11985 ENOG4105W1Y Transcriptional regulator C2U31_11990 ENOG4105ETT transcriptional Regulator, LysR family C2U31_11995 ENOG4105BZC d-serine deaminase C2U31_12000 ENOG4105CSP Major Facilitator Superfamily C2U31_12030 ENOG4105D5G Transposase C2U31_12065 ENOG4105DWY Agmatine deiminase C2U31_12095 ENOG41079KZ Major Facilitator Superfamily C2U31_12105 ENOG4105CD3 dihydroorotase C2U31_12115 ENOG4105DHQ Histidine kinase C2U31_12125 ENOG4105D4T Citrate transporter C2U31_12130 ENOG4105CHR reductase C2U31_12175 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) C2U31_12185 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme C2U31_12190 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) C2U31_12195 ENOG4107RGD Major Facilitator superfamily C2U31_12210 ENOG4105DFS Conserved Protein C2U31_12225 ENOG4105BZS acriflavin resistance protein C2U31_12240 ENOG4105C94 Transporter C2U31_12250 ENOG4105DKK Benzoate C2U31_12255 ENOG4105C8Y Acetylornithine aminotransferase C2U31_12260 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C2U31_12275 ENOG4105BZS acriflavin resistance protein C2U31_12290 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C2U31_12295 ENOG4105BZS acriflavin resistance protein C2U31_12300 ENOG4105C1P efflux transporter, rnd family, mfp subunit C2U31_12305 ENOG4108IG5 Transcriptional regulator C2U31_12310 ENOG4108R4R Iron-regulated virulence regulatory protein C2U31_12320 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C2U31_12325 ENOG4107TE5 Lipid kinase C2U31_12330 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) C2U31_12355 ENOG4108Z9W Outer membrane porin C2U31_12360 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C2U31_12365 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U31_12370 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C2U31_12375 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U31_12390 ENOG4108IEH NADH dehydrogenase subunit g C2U31_12395 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) C2U31_12400 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U31_12405 ENOG4105DF2 NADH dehydrogenase subunit j C2U31_12410 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U31_12420 ENOG4105C8S subunit m C2U31_12425 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2U31_12435 ENOG4108ESX Receptor C2U31_12440 ENOG4105EAC phosphoserine phosphatase C2U31_12445 ENOG4108JA2 transcriptioN-repair coupling factor C2U31_12450 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C2U31_12455 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C2U31_12465 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C2U31_12470 ENOG4105D3R alkyl hydroperoxide reductase C2U31_12475 ENOG4105E0F Histidine kinase C2U31_12480 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2U31_12485 ENOG41072GX Peptidase M22 Glycoprotease C2U31_12490 ENOG4108UN4 phage SPO1 DNA polymerase-related protein C2U31_12495 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) C2U31_12500 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C2U31_12510 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C2U31_12515 ENOG4107HP6 Transcriptional regulator C2U31_12535 ENOG4105DWV Homoserine O-trans-acetylase C2U31_12540 ENOG4107TF3 peptidylprolyl cis-trans isomerase C2U31_12550 ENOG4107835 probably involved in intracellular septation (By similarity) C2U31_12555 ENOG4105E0X reductase C2U31_12560 ENOG4108JJB ABC transporter C2U31_12565 ENOG4107QCX Transporter C2U31_12570 ENOG4107ZYJ bioY protein C2U31_12585 ENOG4105C0Z ABC transporter C2U31_12590 ENOG4108IV0 ABC, transporter C2U31_12600 ENOG4105HSS phospholipase C C2U31_12605 ENOG4105CM2 brancheD-chain amino acid aminotransferase C2U31_12615 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_12625 ENOG4108IV0 ABC, transporter C2U31_12630 ENOG4105C0Z ABC transporter C2U31_12635 ENOG4105CSM endonuclease III C2U31_12640 ENOG4108R3D Electron transport complex C2U31_12660 ENOG4105DP0 ferredoxin-NADP reductase C2U31_12665 ENOG4108Z4U Ferredoxin C2U31_12675 ENOG4105M4H endoribonuclease L-psp C2U31_12685 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) C2U31_12690 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C2U31_12695 ENOG4105CSH Transporter C2U31_12700 ENOG4105CWC Acetylornithine deacetylase C2U31_12705 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C2U31_12710 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) C2U31_12715 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) C2U31_12725 ENOG4105DFS Conserved Protein C2U31_12740 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C2U31_12810 ENOG4107QJE Chromosome Partitioning Protein C2U31_12885 ENOG4106NZI LysR family Transcriptional regulator C2U31_12960 ENOG41061N2 exported protein C2U31_12965 ENOG4105EQR Transposase IS116 IS110 IS902 C2U31_12970 ENOG4107QQB Ribonuclease E C2U31_12975 ENOG4105EI2 Pseudouridine synthase C2U31_12980 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C2U31_12985 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) C2U31_12990 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) C2U31_12995 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase C2U31_13000 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C2U31_13005 ENOG4108UHJ MAF-like protein C2U31_13010 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein C2U31_13015 ENOG4105VGS 50s ribosomal protein l32 C2U31_13020 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) C2U31_13025 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C2U31_13030 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C2U31_13035 ENOG4105CHR reductase C2U31_13040 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C2U31_13045 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C2U31_13055 ENOG4105EMN RNA polymerase sigma factor C2U31_13070 ENOG4105C0H protease C2U31_13075 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C2U31_13080 ENOG4105C3F Signal peptidase i C2U31_13085 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C2U31_13090 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C2U31_13095 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) C2U31_13100 ENOG4105RQF LysR family Transcriptional regulator C2U31_13115 ENOG4105JN3 extra-cytoplasmic solute receptor family protein C2U31_13120 ENOG4108XRP Membrane C2U31_13135 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C2U31_13145 ENOG4108MP6 LysR family Transcriptional regulator C2U31_13155 ENOG4105C26 Dehydrogenase C2U31_13160 ENOG4107R11 Transcriptional regulator C2U31_13170 ENOG4105K4H Nlp p60 protein C2U31_13175 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C2U31_13180 ENOG4108ZJF Glcg protein C2U31_13190 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C2U31_13195 ENOG4108Q5Y Membrane C2U31_13200 ENOG4105C5W Aldolase C2U31_13220 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase C2U31_13250 ENOG4107YB6 acetyltransferase, (GNAT) family C2U31_13260 ENOG4105D44 asparaginase C2U31_13265 ENOG4108JQ6 ABC transporter C2U31_13270 ENOG4105DEF Extracellular solute-binding protein, family 5 C2U31_13305 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2U31_13315 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C2U31_13325 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C2U31_13340 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) C2U31_13345 ENOG4108Z0R Transferase C2U31_13380 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C2U31_13385 ENOG4108YXA Membrane C2U31_13390 ENOG4105DXD 2-methylcitrate dehydratase C2U31_13395 ENOG4105BZN citrate synthase C2U31_13400 ENOG4105CR4 methylisocitrate lyase C2U31_13405 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C2U31_13410 ENOG4105FDP GntR family transcriptional regulator C2U31_13415 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit C2U31_13420 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein C2U31_13430 ENOG4105E33 succinate dehydrogenase C2U31_13435 ENOG41060IS Flavinator of succinate dehydrogenase C2U31_13440 ENOG4105BZN citrate synthase C2U31_13460 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_13470 ENOG4105C2J ABC transporter C2U31_13475 ENOG4108IV0 ABC, transporter C2U31_13485 ENOG4105DHQ Histidine kinase C2U31_13490 ENOG4105XJC Two component transcriptional regulator (Winged helix family C2U31_13500 ENOG4105JQN Transcriptional regulator C2U31_13510 ENOG4105C6K Malic enzyme C2U31_13515 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) C2U31_13520 ENOG4105EPD Oligopeptide transporter, Opt family C2U31_13530 ENOG4105K6H D-cysteine desulfhydrase C2U31_13535 ENOG4108ZRZ Transcriptional regulator (AsnC family) C2U31_13540 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 C2U31_13545 ENOG4105C7S Dehydrogenase C2U31_13550 ENOG4107QN2 dihydrolipoyl dehydrogenase C2U31_13555 ENOG4105D6Z AFG1 family ATPase C2U31_13580 ENOG4105BZN citrate synthase C2U31_13590 ENOG4105C31 Tryptophanyl-tRNA synthetase C2U31_13605 ENOG4105BZM domain protein C2U31_13610 ENOG4105DVT helicase C2U31_13620 ENOG4105C34 Pseudouridine synthase C2U31_13625 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C2U31_13630 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class C2U31_13635 ENOG4105CHR reductase C2U31_13640 ENOG4108NVM synthesis repressor PhaR C2U31_13665 ENOG4105JAB phenazine biosynthesis protein, phzf family C2U31_13680 ENOG4105VDW Csbd family C2U31_13690 ENOG4107RRY Cyanophycin synthetase C2U31_13695 ENOG4105BZ1 (ABC) transporter C2U31_13710 ENOG4105ED9 Protein of unknown function (DUF455) C2U31_13715 ENOG4105CVE Lytic murein transglycosylase C2U31_13730 ENOG4105C1G acyl-Coa dehydrogenase C2U31_13740 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) C2U31_13750 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C2U31_13760 ENOG4108XTA Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate C2U31_13770 ENOG410802X bacteriophage n4 adsorption protein b C2U31_13780 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C2U31_13790 ENOG4107R08 Integrase C2U31_13915 ENOG4105CDU Replicative dna helicase C2U31_14035 ENOG4105TKZ Tail Sheath C2U31_14075 ENOG4108T86 baseplate J family protein C2U31_14090 ENOG4105UZW Tail fiber assembly protein C2U31_14145 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C2U31_14150 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) C2U31_14155 ENOG4105UYK outer membrane protein a C2U31_14160 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2U31_14165 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C2U31_14175 ENOG4105CIH Imidazole acetol-phosphate transaminase C2U31_14185 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C2U31_14190 ENOG4105CAT Cytidine monophosphate kinase C2U31_14195 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C2U31_14210 ENOG4105CFV Tetratricopeptide repeat protein C2U31_14215 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) C2U31_14220 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) C2U31_14225 ENOG4105KQC Competence protein C2U31_14230 ENOG4105C6T cysteine synthase C2U31_14245 ENOG4105BZJ Electron transfer flavoprotein C2U31_14250 ENOG4105C10 Electron transfer flavoprotein C2U31_14255 ENOG4105D3R alkyl hydroperoxide reductase C2U31_14260 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein C2U31_14265 ENOG4108I5D sulfate abc transporter C2U31_14270 ENOG4105ECW sulfate abc transporter C2U31_14290 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) C2U31_14310 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C2U31_14315 ENOG4105P8F nudix hydrolase C2U31_14320 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C2U31_14325 ENOG4105D0M Protease HtpX homolog C2U31_14330 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) C2U31_14340 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein C2U31_14345 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit C2U31_14350 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit C2U31_14355 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit C2U31_14360 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit C2U31_14365 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C2U31_14375 ENOG4108UKI Enoyl-CoA hydratase C2U31_14380 ENOG4108ZJI phenylacetic acid degradation protein C2U31_14390 ENOG4107QI1 Mate efflux family protein C2U31_14400 ENOG4105NRA 50s ribosomal protein l31 type b C2U31_14405 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) C2U31_14410 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) C2U31_14415 ENOG4105W5Q DNA repair protein (RadC C2U31_14430 ENOG4108RXX maleylacetoacetate isomerase C2U31_14435 ENOG4105C0H protease C2U31_14440 ENOG4105DHQ Histidine kinase C2U31_14445 ENOG4105XJC Two component transcriptional regulator (Winged helix family C2U31_14460 ENOG4105CKI cobalamin synthesis protein C2U31_14465 ENOG4105EJC lysr family transcriptional regulator C2U31_14475 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C2U31_14480 ENOG4105FE9 pseudouridine synthase C2U31_14485 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) C2U31_14490 ENOG4105CHV Transcription elongation factor NusA C2U31_14495 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C2U31_14500 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C2U31_14505 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C2U31_14520 ENOG4105F04 LysR family Transcriptional regulator C2U31_14525 ENOG4108URH decarboxylase C2U31_14530 ENOG4105C2M dna polymerase I C2U31_14535 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) C2U31_14540 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) C2U31_14545 ENOG4105EAM Na Pi-cotransporter C2U31_14550 ENOG4105EJQ L-serine dehydratase C2U31_14555 ENOG4105ETE Transcriptional regulator (LacI family C2U31_14560 ENOG4105E9Z Nad-dependent epimerase dehydratase C2U31_14565 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C2U31_14570 ENOG4108HWW ABC transporter C2U31_14580 ENOG4105DFW ABC transporter C2U31_14585 ENOG4105TW1 Carbohydrate-selective porin OprB C2U31_14590 ENOG4105D0M Protease HtpX homolog C2U31_14600 ENOG4105KHC sulfurtransferase C2U31_14610 ENOG4105DUM transcriptional regulator, lysR family C2U31_14615 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U31_14625 ENOG4108KAZ Involved in phosphonate degradation (By similarity) C2U31_14660 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C2U31_14665 ENOG4105CTB Polyprenyl synthetase C2U31_14670 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C2U31_14675 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) C2U31_14680 ENOG4105NX3 Membrane C2U31_14685 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C2U31_14695 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C2U31_14700 ENOG4105K9Q Binds to the 23S rRNA (By similarity) C2U31_14710 ENOG4105CDU Replicative dna helicase C2U31_14715 ENOG4105DHU Bile acid C2U31_14720 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) C2U31_14730 ENOG4105EW9 transcriptional regulator AsnC family C2U31_14755 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U31_14810 ENOG4105CXT aspartate transcarbamylase C2U31_14830 ENOG4105CSH Transporter C2U31_14835 ENOG4105DHQ Histidine kinase C2U31_14845 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) C2U31_14850 ENOG4108004 Modulates RecA activity (By similarity) C2U31_14855 ENOG4105DZ2 Transcriptional regulator C2U31_14860 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C2U31_14865 ENOG4105CEY Amp-dependent synthetase and ligase C2U31_14875 ENOG4105CMV Succinyl-CoA synthetase subunit beta C2U31_14880 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C2U31_14885 ENOG4108ZCF integral membrane protein C2U31_14890 ENOG4108ZCF integral membrane protein C2U31_14895 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C2U31_14915 ENOG4105F0N pyrophosphate phospho-hydrolase C2U31_14940 ENOG4105CHR reductase C2U31_14945 ENOG4105C0Z ABC transporter C2U31_14950 ENOG4108IV0 ABC, transporter C2U31_14955 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_14975 ENOG4108IAB Phoh family C2U31_14980 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C2U31_14990 ENOG4105CHM Aminotransferase C2U31_14995 ENOG4105D6E homoserine dehydrogenase C2U31_15010 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 C2U31_15015 ENOG4105CD8 aminopeptidase N C2U31_15025 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS C2U31_15030 ENOG4105D1U peptidase U62 modulator of DNA gyrase C2U31_15035 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C2U31_15040 ENOG4105CQB FAD linked oxidase domain protein C2U31_15045 ENOG4105CQB FAD linked oxidase domain protein C2U31_15050 ENOG4105EU8 FAD linked oxidase domain protein C2U31_15055 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C2U31_15060 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) C2U31_15065 ENOG4105W8H transhydrogenase (subunit alpha C2U31_15070 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) C2U31_15085 ENOG4105ETT transcriptional Regulator, LysR family C2U31_15090 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C2U31_15100 ENOG4108U78 Glutathione S-transferase C2U31_15105 ENOG4107QTF adenylosuccinate lyase C2U31_15110 ENOG4105T86 cytochrome C C2U31_15280 ENOG4105BZU Histidine kinase C2U31_15285 ENOG4105RPH Inner membrane protein YddG C2U31_15325 ENOG4105CBC glutamate synthase C2U31_15330 ENOG41066VF YeeE YedE family protein C2U31_15340 ENOG4107R5R arsenical pump membrane protein C2U31_15350 ENOG4108KTG Membrane protein, drug metabolite transporter C2U31_15355 ENOG41082BV acetyltransferase C2U31_15360 ENOG4105DND Transcriptional regulator C2U31_15365 ENOG41079KZ Major Facilitator Superfamily C2U31_15385 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C2U31_15390 ENOG4105ECQ AraC Family Transcriptional Regulator C2U31_15395 ENOG4105EJQ L-serine dehydratase C2U31_15410 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C2U31_15445 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C2U31_15450 ENOG4105C2N RNA methyltransferase TrmH family group 3 C2U31_15455 ENOG4105C28 cystathionine C2U31_15460 ENOG4107E2E PKHD-type hydroxylase C2U31_15465 ENOG4105K70 DNA-binding protein C2U31_15485 ENOG4105SG9 biopolymer transport protein, ExbD C2U31_15490 ENOG4105XJC Two component transcriptional regulator (Winged helix family C2U31_15495 ENOG4105DHQ Histidine kinase C2U31_15500 ENOG4105DFH Transport of potassium into the cell (By similarity) C2U31_15505 ENOG4105CDH Citrulline--aspartate ligase C2U31_15510 ENOG4105C5Q Transcriptional regulator C2U31_15515 ENOG4105GAK amidohydrolase 2 C2U31_15535 ENOG4105DBV ornithine carbamoyltransferase C2U31_15540 ENOG4105C8Y Acetylornithine aminotransferase C2U31_15555 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C2U31_15565 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C2U31_15570 ENOG4105CV6 ABC transporter, permease C2U31_15580 ENOG4105CMT Dihydroxyacetone kinase C2U31_15585 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) C2U31_15595 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U31_15600 ENOG4105F38 ABC transporter, permease C2U31_15605 ENOG4105D38 putrescine abc transporter C2U31_15610 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) C2U31_15615 ENOG4108RB4 3-methyladenine DNA glycosylase C2U31_15625 ENOG4107QSV RmuC domain protein C2U31_15635 ENOG4105CSU acyl-Coa dehydrogenase C2U31_15640 ENOG4105E66 phosphoriboisomerase A C2U31_15655 ENOG4108UTW Plays a role in the regulation of phosphate uptake C2U31_15710 ENOG4105HSS phospholipase C C2U31_15720 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) C2U31_15725 ENOG4108EKC n-acetylglutamate synthase C2U31_15730 ENOG4105CQ7 ATP-dependent helicase C2U31_15750 ENOG4105C0B DNA polymerase III (alpha subunit) C2U31_15755 ENOG4105CPK Glycosyl transferase (Group 1 C2U31_15760 ENOG4107BJW polysaccharide deacetylase C2U31_15765 ENOG4106WTF Glycosyl transferase, family 2 C2U31_15775 ENOG4107BJW polysaccharide deacetylase C2U31_15785 ENOG4105CUT histidyl-tRNA synthetase C2U31_15790 ENOG4105KRS Proteinase inhibitor C2U31_15805 ENOG4105BZ1 (ABC) transporter C2U31_15810 ENOG4105CKD glutathione-regulated potassium-efflux system protein C2U31_15820 ENOG4105BZU Histidine kinase C2U31_15845 ENOG4105C03 ribonuclease C2U31_15880 ENOG4105MP9 class II Aldolase C2U31_15905 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) C2U31_15915 ENOG4105C57 major facilitator superfamily C2U31_15925 ENOG4105EUF amidase EC 3.5.1.4 C2U31_15930 ENOG4105VDT -acetyltransferase C2U31_15945 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) C2U31_15960 ENOG4105C8T Leucyl-tRNA synthetase C2U31_15980 ENOG4105DZ1 carboxypeptidase C2U31_16000 ENOG4105C0Z ABC transporter C2U31_16015 ENOG4105W0E 50S ribosomal protein L33 C2U31_16020 ENOG4105KDC 50s ribosomal protein l28 C2U31_16025 ENOG4105C2C drug resistance transporter, Bcr CflA C2U31_16045 ENOG4108HQS Glycine betaine C2U31_16050 ENOG4108IJ7 Glycine betaine C2U31_16060 ENOG4105CHU acetyl-coa acetyltransferase C2U31_16070 ENOG4105DRR Transcriptional regulator, GntR family C2U31_16080 ENOG41060WC Enoyl-CoA hydratase C2U31_16085 ENOG4105CEY Amp-dependent synthetase and ligase C2U31_16095 ENOG4108SF5 RNA Polymerase C2U31_16100 ENOG4108S3W Anti-feci sigma factor, fecr C2U31_16105 ENOG4105CNM Receptor C2U31_16120 ENOG4105C7J ABC transporter, permease C2U31_16125 ENOG4105D5T phosphonate abc transporter C2U31_16155 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C2U31_16160 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C2U31_16165 ENOG4105E0C molybdate abc transporter C2U31_16170 ENOG4108IJ6 ABC transporter C2U31_16175 ENOG4105F4R Transcriptional regulator mode C2U31_16195 ENOG4105C1P efflux transporter, rnd family, mfp subunit C2U31_16200 ENOG4105BZS acriflavin resistance protein C2U31_16210 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) C2U31_16215 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) C2U31_16220 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) C2U31_16225 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C2U31_16230 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C2U31_16240 ENOG4105CA0 peroxidase C2U31_16245 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C2U31_16255 ENOG4108WYP Transcriptional regulator C2U31_16260 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C2U31_16265 ENOG4105C2J ABC transporter C2U31_16270 ENOG4105CNN ABC, transporter C2U31_16275 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) C2U31_16280 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme C2U31_16285 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein C2U31_16290 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) C2U31_16300 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C2U31_16305 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C2U31_16320 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i C2U31_16340 ENOG4105C58 cytochrome c oxidase accessory protein ccog C2U31_16365 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) C2U31_16370 ENOG4105CXK mandelate racemase muconate lactonizing C2U31_16380 ENOG4105DA5 (ABC) transporter C2U31_16385 ENOG4105E3A (ABC) transporter C2U31_16415 ENOG4108UT2 hemolysin iii C2U31_16475 ENOG4105E39 Enoyl-CoA hydratase C2U31_16480 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C2U31_16485 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2U31_16490 ENOG4105JXH GntR family transcriptional regulator C2U31_16510 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C2U31_16525 ENOG4105UEI Transcriptional Regulator AraC Family C2U31_16530 ENOG4105DNH Major Facilitator C2U31_16540 ENOG4105D01 (LipO)protein C2U31_16545 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2U31_16550 ENOG4108UMI ABC transporter, permease C2U31_16570 ENOG4105CSR polyphosphate kinase 2 C2U31_16575 ENOG4105VEJ Heat shock protein C2U31_16585 ENOG4105BZU Histidine kinase C2U31_16620 ENOG4105F7F Chaperone C2U31_16625 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) C2U31_16635 ENOG4105CPF Cell wall formation (By similarity) C2U31_16645 ENOG41061WM D-Alanyl-D-Alanine C2U31_16670 ENOG4105CH2 amidohydrolase C2U31_16680 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) C2U31_16700 ENOG4105CVE Lytic murein transglycosylase C2U31_16705 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) C2U31_16720 ENOG4105K5X acetyltransferase C2U31_16730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U31_16735 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U31_16740 ENOG4108J59 Extracellular solute-binding protein, family 5 C2U31_16745 ENOG4108JQ6 ABC transporter C2U31_16765 ENOG4105YES addiction module antidote protein C2U31_16795 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C2U31_16800 ENOG4108KPJ rna polymerase sigma factor C2U31_16815 ENOG4105VRT cytoplasmic protein C2U31_16820 ENOG4105C22 threonyL-tRNA synthetase C2U31_16825 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C2U31_16830 ENOG4105D7Z glutathione synthase C2U31_16840 ENOG41080Z8 PHOSPHOCARRIER protein C2U31_16845 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C2U31_16850 ENOG4105BZU Histidine kinase C2U31_16855 ENOG4108YZA Nitrogen regulatory protein pii C2U31_16865 ENOG4105W0Z cytoplasmic protein C2U31_16870 ENOG4105C0P Mg chelatase subunit ChlI C2U31_16875 ENOG4105VJV 50s ribosomal protein L35 C2U31_16880 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C2U31_16885 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C2U31_16890 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C2U31_16895 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) C2U31_16915 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C2U31_16925 ENOG4105H3G oxidoreductase C2U31_16935 ENOG4105JAB phenazine biosynthesis protein, phzf family C2U31_16970 ENOG4108YXU transcriptional regulator AsnC family C2U31_17000 ENOG4108MGI Transcriptional regulator C2U31_17050 ENOG4105DHU Bile acid C2U31_17060 ENOG4108JJ7 ABC transporter C2U31_17065 ENOG4105CV8 reductase C2U31_17080 ENOG4108R1E Serine threonine protein phosphatase 1 C2U31_17085 ENOG4108JQC penicillin-binding protein 1A C2U31_17090 ENOG41075H3 AraC family transcriptional regulator C2U31_17095 ENOG4105EU0 Major facilitator Superfamily C2U31_17105 ENOG4105CND Glycosyl transferase, family 2 C2U31_17110 ENOG4107BJW polysaccharide deacetylase C2U31_17115 ENOG4108TUY outer membrane protein PgaA C2U31_17120 ENOG4105BZU Histidine kinase C2U31_17140 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C2U31_17145 ENOG4105KTH gatB Yqey C2U31_17150 ENOG4105CVI Transcriptional regulator C2U31_17155 ENOG4105MDS 4-oxalocrotonate tautomerase C2U31_17160 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C2U31_17170 ENOG4105MWK D-amino acid dehydrogenase, small subunit C2U31_17180 ENOG41062BK proline dehydrogenase C2U31_17200 ENOG4105ETT transcriptional Regulator, LysR family C2U31_17205 ENOG4105EXG Transcriptional regulator C2U31_17230 ENOG4105CSU acyl-Coa dehydrogenase C2U31_17235 ENOG4105CEY Amp-dependent synthetase and ligase C2U31_17250 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) C2U31_17255 ENOG4105E82 cytochrome subunit of dehydrogenase C2U31_17270 ENOG4108W3Y Transcriptional regulator, Crp Fnr family C2U31_17275 ENOG4108UVJ appr-1-p processing domain protein C2U31_17280 ENOG4105E6M Sulphatase-modifying factor protein C2U31_17285 ENOG4105DSQ Nitric oxide reductase C2U31_17290 ENOG4105DC8 reductase C2U31_17295 ENOG4105N14 lysine exporter protein LysE YggA C2U31_17300 ENOG4108ZM9 phosphoglycerate mutase C2U31_17320 ENOG4108Q5Y Membrane C2U31_17340 ENOG4107QI1 Mate efflux family protein C2U31_17345 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) C2U31_17355 ENOG4108I0C methyltransferase C2U31_17360 ENOG4105ETE Transcriptional regulator (LacI family C2U31_17365 ENOG4105DJB Major Facilitator Superfamily C2U31_17370 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2U31_17380 ENOG4105EVD ribosomal RNA large subunit methyltransferase N C2U31_17415 ENOG41073TP transcriptional regulator C2U31_17425 ENOG4108R6K riboflavin synthase, subunit alpha C2U31_17435 ENOG4105CSP Major Facilitator Superfamily C2U31_17445 ENOG4108MK9 spermidine N(1)-acetyltransferase C2U31_17450 ENOG4105CYB regulatoR C2U31_17460 ENOG4105E0Y RtcB Protein C2U31_17465 ENOG410756H nucleotidyltransferase C2U31_17480 ENOG4105W1Y Transcriptional regulator C2U31_17495 ENOG4107RUE extracellular solute-binding protein family 1 C2U31_17500 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U31_17505 ENOG4105F38 ABC transporter, permease C2U31_17520 ENOG4105CHR reductase C2U31_17525 ENOG4105CHR reductase C2U31_17530 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2U31_17535 ENOG4107R0V Pyruvate dehydrogenase C2U31_17540 ENOG4105CPP Dehydrogenase, E1 component C2U31_17545 ENOG4107QSN dihydrolipoamide acetyltransferase C2U31_17550 ENOG4107QN2 dihydrolipoyl dehydrogenase C2U31_17560 ENOG4105F27 Major Facilitator C2U31_17570 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2U31_17575 ENOG4105CH7 arginosuccinase C2U31_17580 ENOG4105CUY Mechanosensitive ion channel C2U31_17590 ENOG4108YZA Nitrogen regulatory protein pii C2U31_17595 ENOG4105D7Q type ii secretion system C2U31_17600 ENOG4105GVR general secretion pathway protein D C2U31_17605 ENOG4107QHF type ii secretion system protein e C2U31_17620 ENOG4105C2W permease C2U31_17625 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) C2U31_17645 ENOG4105VT2 5-hydroxyisourate hydrolase C2U31_17650 ENOG4105CA9 Pyruvate kinase C2U31_17660 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C2U31_17665 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) C2U31_17670 ENOG41060W2 glyoxylate carboligase C2U31_17675 ENOG4105CC0 LysR family Transcriptional regulator C2U31_17680 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2U31_17690 ENOG4105EMY transcriptional regulator C2U31_17715 ENOG4108WWZ General secretion pathway protein J C2U31_17725 ENOG41069X0 general secretion pathway protein h C2U31_17730 ENOG4108VAU general secretion pathway protein G C2U31_17745 ENOG4105HSS phospholipase C C2U31_17750 ENOG4105DUM transcriptional regulator, lysR family C2U31_17755 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C2U31_17765 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U31_17770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U31_17775 ENOG4108JQ6 ABC transporter C2U31_17790 ENOG4105N14 lysine exporter protein LysE YggA C2U31_17795 ENOG4108VWS Yaeq family C2U31_17815 ENOG4105C57 major facilitator superfamily C2U31_17820 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) C2U31_17825 ENOG4105FE9 pseudouridine synthase C2U31_17830 ENOG4105JQN Transcriptional regulator C2U31_17835 ENOG4105C1P efflux transporter, rnd family, mfp subunit C2U31_17840 ENOG4105BZS acriflavin resistance protein C2U31_17845 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C2U31_17865 ENOG4105DGW oligopeptidase A C2U31_17875 ENOG4108ZXC Two component transcriptional regulator, luxr family C2U31_17880 ENOG4105BZU Histidine kinase C2U31_17885 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) C2U31_17890 ENOG4107QSN dihydrolipoamide acetyltransferase C2U31_17895 ENOG4107QN2 dihydrolipoyl dehydrogenase C2U31_17900 ENOG4105DFS Conserved Protein C2U31_17930 ENOG4106R49 Methyltransferase C2U31_17935 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2U31_17940 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) C2U31_17945 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region C2U31_17950 ENOG4107RD7 Flagellar Motor Protein, MotA C2U31_17955 ENOG4105ER2 Ompa motb domain protein C2U31_17965 ENOG4105CBS Chea signal transduction histidine kinase C2U31_17970 ENOG4108V3W Chemotaxis protein, CheW C2U31_17975 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_17980 ENOG4105BZU Histidine kinase C2U31_17985 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C2U31_17990 ENOG4108VYJ response regulator receiver protein C2U31_17995 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) C2U31_18005 ENOG4105D00 flagellar biosynthetic protein flhB C2U31_18010 ENOG4105D7B Flagellar biosynthesis protein flha C2U31_18015 ENOG4105FZW flagellar biosynthesis regulator FlhF C2U31_18015 ENOG4105FZW flagellar biosynthesis regulator FlhF C2U31_18025 ENOG4105M9M anti-sigma28 factor FlgM C2U31_18035 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C2U31_18040 ENOG4108ZC9 flagellar basal-body rod protein flgc C2U31_18045 ENOG4105W00 Flagellar hook capping protein C2U31_18050 ENOG4105BZE flagellar hook protein, FlgE C2U31_18055 ENOG4108KPB Flagellar basal-body rod protein FlgF C2U31_18060 ENOG4105CGA flagellar basal-body rod protein FlgG C2U31_18065 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) C2U31_18070 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) C2U31_18075 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj C2U31_18080 ENOG4105E1Q flagellar hook-associated protein C2U31_18085 ENOG4105DTJ flagellar hook-associated protein C2U31_18090 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_18095 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_18105 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_18110 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C2U31_18115 ENOG4105VS8 Flagellar biosynthetic protein fliq C2U31_18120 ENOG4105CN7 Flagellar biosynthetic protein FliP C2U31_18130 ENOG4105DD5 Flagellar motor switch protein C2U31_18135 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C2U31_18140 ENOG4107ZI8 flagellar basal body-associated protein flil C2U31_18155 ENOG4108JIR Flagellum-specific ATP synthase C2U31_18165 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C2U31_18170 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C2U31_18175 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C2U31_18185 ENOG4105D00 flagellar biosynthetic protein flhB C2U31_18200 ENOG4105MQ3 flagellar protein FliS C2U31_18205 ENOG4105DTS flagellar hook-associated C2U31_18225 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C2U31_18240 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C2U31_18255 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase C2U31_18260 ENOG4108VKG metal-dependent hydrolase C2U31_18270 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) C2U31_18280 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) C2U31_18285 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C2U31_18290 ENOG4105CE9 30S ribosomal protein S2 C2U31_18295 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) C2U31_18300 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C2U31_18305 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C2U31_18310 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C2U31_18315 ENOG4105KNE Phosphatidate cytidylyltransferase C2U31_18320 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C2U31_18325 ENOG4105DZP Membrane-associated zinc metalloprotease C2U31_18330 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane C2U31_18335 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) C2U31_18340 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C2U31_18345 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C2U31_18355 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C2U31_18360 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C2U31_18375 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C2U31_18380 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C2U31_18385 ENOG4105C57 major facilitator superfamily C2U31_18395 ENOG4107Z3H Transcriptional regulator, TetR family C2U31_18400 ENOG4105F9N Major Facilitator Superfamily C2U31_18405 ENOG410624X efflux transporter, rnd family, mfp subunit C2U31_18410 ENOG4105BZS acriflavin resistance protein C2U31_18420 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C2U31_18425 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C2U31_18435 ENOG4107QX8 SPFH domain, Band 7 family protein C2U31_18440 ENOG4105BZU Histidine kinase C2U31_18445 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C2U31_18450 ENOG4108Z1B Cyclase dehydrase C2U31_18455 ENOG4105VDB UPF0125 protein C2U31_18460 ENOG4105C1G acyl-Coa dehydrogenase C2U31_18465 ENOG4108IPT Naphthoate synthase C2U31_18470 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C2U31_18485 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) C2U31_18490 ENOG4105HHA aminodeoxychorismate lyase C2U31_18495 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C2U31_18500 ENOG4105C6E dna polymerase iii C2U31_18505 ENOG4105F8V Hydrolase, tatD family C2U31_18520 ENOG4106TNF Periplasmic binding protein C2U31_18525 ENOG4105E5Q amino acid AbC transporter C2U31_18530 ENOG4105CDA abc transporter atp-binding protein C2U31_18535 ENOG41088SP formiminoglutamate hydrolase C2U31_18545 ENOG4105D82 Glutamate dehydrogenase C2U31_18560 ENOG4105DF9 Lipoate-protein, ligase C2U31_18575 ENOG4105CYM Glutathione S-transferase C2U31_18585 ENOG4108YXU transcriptional regulator AsnC family C2U31_18590 ENOG4105ETS cytosine purines uracil thiamine allantoin C2U31_18605 ENOG4105F27 Major Facilitator C2U31_18620 ENOG4105WAP TPR repeat-containing protein C2U31_18635 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C2U31_18640 ENOG4105CVP deoxyribo-dipyrimidine photolyase C2U31_18645 ENOG410846T CoA-transferase family III C2U31_18675 ENOG4108K88 Membrane C2U31_18740 ENOG4105F7P transcriptional regulator AsnC family C2U31_18745 ENOG4108UVJ appr-1-p processing domain protein C2U31_18765 ENOG4105CYM Glutathione S-transferase C2U31_18805 ENOG4105C1J atp-dependent rna helicase C2U31_18820 ENOG4108FUF Transcriptional regulator, IclR family C2U31_18840 ENOG4108XM1 transcriptional regulator AsnC family C2U31_18850 ENOG4108J59 Extracellular solute-binding protein, family 5 C2U31_18855 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U31_18860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U31_18875 ENOG4105CI2 imidazolone-5-propionate hydrolase C2U31_18895 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U31_18900 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C2U31_18910 ENOG4106FTQ Taurine ABC transporter, periplasmic C2U31_18930 ENOG4105J4Q Transcriptional regulator C2U31_18935 ENOG4105ERH Fumarylacetoacetate hydrolase C2U31_18940 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr C2U31_18950 ENOG4105CTX dehydratase C2U31_18955 ENOG4105EAD ABC transporter C2U31_18960 ENOG4105DRP amino acid AbC transporter C2U31_18970 ENOG4107RP9 extracellular solute-binding protein, family 3 C2U31_18975 ENOG4105DIA mandelate racemase muconate lactonizing C2U31_18980 ENOG4105EUJ GTP cyclohydrolase i C2U31_18995 ENOG4105D22 carbon starvation protein C2U31_19000 ENOG4105VCD cytoplasmic protein C2U31_19010 ENOG4105EZR dyp-type peroxidase family protein C2U31_19015 ENOG4105F27 Major Facilitator C2U31_19025 ENOG4107RN3 metallophosphoesterase C2U31_19035 ENOG4105DJ4 phosphatidylserine decarboxylase C2U31_19040 ENOG4105C5H ABC transporter C2U31_19060 ENOG4108J3H Dehydrogenase C2U31_19065 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C2U31_19070 ENOG4108NJZ Sensory box GGDEF EAL domain protein C2U31_19080 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) C2U31_19110 ENOG4107U7B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C2U31_19115 ENOG4105E0X reductase C2U31_19125 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) C2U31_19130 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) C2U31_19135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2U31_19140 ENOG4105BZU Histidine kinase C2U31_19150 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C2U31_19160 ENOG4105EA8 2-Nitropropane dioxygenase C2U31_19200 ENOG4105C5Q Transcriptional regulator C2U31_19215 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U31_19225 ENOG4105FDP GntR family transcriptional regulator C2U31_19230 ENOG4105CP9 extracellular ligand-binding receptor C2U31_19235 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_19240 ENOG4105CF8 branched-chain amino acid ABC transporter, permease C2U31_19245 ENOG4105C0Z ABC transporter C2U31_19250 ENOG4108IV0 ABC, transporter C2U31_19255 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C2U31_19260 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C2U31_19280 ENOG4108IYU L-aspartate oxidase C2U31_19290 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) C2U31_19295 ENOG41080TK Universal stress protein C2U31_19310 ENOG4105DS0 Transcriptional regulator, Crp Fnr family C2U31_19320 ENOG4105BZU Histidine kinase C2U31_19330 ENOG41080XQ Signal transduction protein with cbs domains C2U31_19335 ENOG4105CY0 Metallo-Beta-Lactamase C2U31_19355 ENOG4105CR8 Transcriptional regulator C2U31_19360 ENOG41061H0 Monooxygenase C2U31_19375 ENOG4105DQQ Major facilitator superfamily MFS_1 C2U31_19380 ENOG4105CRU nitrate reductase, alpha subunit C2U31_19385 ENOG4108IUE nitrate reductase beta subunit C2U31_19390 ENOG4105R3A Nitrate reductase C2U31_19395 ENOG41076YT nitrate reductase, gamma subunit C2U31_19400 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) C2U31_19405 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C2U31_19410 ENOG4107B2H carbonic anhydrase C2U31_19415 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b C2U31_19420 ENOG4105BZU Histidine kinase C2U31_19425 ENOG4105WH1 Two component transcriptional regulator luxr family C2U31_19430 ENOG4105CFP Peptidase U32 C2U31_19435 ENOG4106RZ4 Peptidase U32 C2U31_19440 ENOG4105XPQ lipid carrier protein C2U31_19445 ENOG4105EMU Dehydrogenase C2U31_19450 ENOG4105EZ7 amino acid ABC transporter C2U31_19455 ENOG4107QXX ABC transporter C2U31_19475 ENOG4105ECQ AraC Family Transcriptional Regulator C2U31_19490 ENOG4105D7T ABC transporter C2U31_19495 ENOG4105I5W Transporter C2U31_19500 ENOG4105DG7 nitrate ABC transporter C2U31_19510 ENOG4107RNH Outer membrane receptor FepA C2U31_19560 ENOG4105E0K tonB-dependent siderophore receptor C2U31_19565 ENOG4105IKQ hydratase C2U31_19575 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase C2U31_19580 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase C2U31_19595 ENOG4105FUY alpha subunit C2U31_19605 ENOG4105CSH Transporter C2U31_19610 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase C2U31_19680 ENOG4105F27 Major Facilitator C2U31_19685 ENOG4105KHC sulfurtransferase C2U31_19690 ENOG41066VF YeeE YedE family protein C2U31_19710 ENOG4108ZXC Two component transcriptional regulator, luxr family C2U31_19730 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C2U31_19775 ENOG4107ZT5 Thiol disulfide interchange protein C2U31_19780 ENOG4106611 bacteriocin immunity C2U31_19790 ENOG4105CBN LysR family transcriptional regulator C2U31_19795 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C2U31_19810 ENOG4108RXX maleylacetoacetate isomerase C2U31_19835 ENOG4105EAB amino acid AbC transporter C2U31_19840 ENOG4105E5Q amino acid AbC transporter C2U31_19845 ENOG4105CDA abc transporter atp-binding protein C2U31_19880 ENOG4105E0A ABC, transporter C2U31_19885 ENOG4105TVJ transport system, permease C2U31_19890 ENOG4105DQ5 transport system permease protein C2U31_19895 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C2U31_19900 ENOG4105CNM Receptor C2U31_19905 ENOG4105D94 Major Facilitator Superfamily C2U31_19945 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2U31_19955 ENOG4105DQR SNARE associated Golgi C2U31_19960 ENOG4107QJQ Mate efflux family protein C2U31_19965 ENOG4105E9K Isocitrate dehydrogenase C2U31_19970 ENOG4105C7B Threonine dehydratase C2U31_19985 ENOG4105CMR udp-glucose 4-epimerase C2U31_19995 ENOG4105ERH Fumarylacetoacetate hydrolase C2U31_20045 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) C2U31_20050 ENOG4105CYM Glutathione S-transferase C2U31_20070 ENOG4106A3M Cytochrome p-450 C2U31_20100 ENOG4107RCI amp-dependent synthetase and ligase C2U31_20140 ENOG4108AHD Transcriptional regulator C2U31_20150 ENOG4105F95 Monooxygenase C2U31_20160 ENOG4105C0A alcohol dehydrogenase C2U31_20165 ENOG4108YZG isomerase C2U31_20170 ENOG4105VPX protein, conserved in bacteria C2U31_20175 ENOG41061MD high-affinity nickel-transporter C2U31_20185 ENOG4108YV4 Universal stress protein C2U31_20190 ENOG4107QRI Phosphoketolase C2U31_20195 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C2U31_20205 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2U31_20225 ENOG4105VN1 Heat shock protein C2U31_20250 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C2U31_20255 ENOG4108MGI Transcriptional regulator C2U31_20275 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr C2U31_20280 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2U31_20290 ENOG4105JQN Transcriptional regulator C2U31_20310 ENOG4105CGU Enoyl-CoA hydratase C2U31_20315 ENOG4108J2P Alpha beta hydrolase fold C2U31_20330 ENOG4105C5I Dehydrogenase C2U31_20335 ENOG4105FYA Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C2U31_20345 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) C2U31_20380 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C2U31_20390 ENOG4108Z4X TRANSCRIPTIONal C2U31_20400 ENOG4105CH2 amidohydrolase C2U31_20405 ENOG4107F9Y LysR family transcriptional regulator C2U31_20420 ENOG4105BZU Histidine kinase C2U31_20425 ENOG4105BZU Histidine kinase C2U31_20440 ENOG4105X5Z General secretion pathway protein I C2U31_20445 ENOG4105PBE general secretion pathway protein h C2U31_20485 ENOG4108UPW ABC transporter C2U31_20490 ENOG4105D7Q type ii secretion system C2U31_20495 ENOG4107QHF type ii secretion system protein e C2U31_20500 ENOG4105GVR general secretion pathway protein D C2U31_20520 ENOG4108VAU general secretion pathway protein G C2U31_20525 ENOG4108ZT1 Transcriptional regulator C2U31_20530 ENOG4105DJ2 Major Facilitator Superfamily C2U31_20540 ENOG4105C2C drug resistance transporter, Bcr CflA C2U31_20555 ENOG4105JJR Histidine kinase C2U31_20560 ENOG4105EE5 Membrane protein terC C2U31_20575 ENOG4105BZU Histidine kinase C2U31_20590 ENOG4105D01 (LipO)protein C2U31_20610 ENOG4108EHX EamA-like transporter family C2U31_20620 ENOG4105D8V Glucose sorbosone dehydrogenase C2U31_20625 ENOG4108K3A Glutathione S-transferase C2U31_20635 ENOG4108IV0 ABC, transporter C2U31_20640 ENOG4105C0Z ABC transporter C2U31_20645 ENOG4105CF8 branched-chain amino acid ABC transporter, permease C2U31_20650 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_20655 ENOG4105CP9 extracellular ligand-binding receptor C2U31_20660 ENOG4105EX9 Membrane C2U31_20665 ENOG4105II7 pyrroline-5-carboxylate reductase C2U31_20670 ENOG4105BZ7 extracellular solute-binding protein family 1 C2U31_20685 ENOG4108IJ9 (ABC) transporter C2U31_20700 ENOG4105JJR Histidine kinase C2U31_20705 ENOG4107EXC regulatoR C2U31_20710 ENOG4105CP9 extracellular ligand-binding receptor C2U31_20730 ENOG4105CB5 ATP-dependent DNA helicase recG C2U31_20735 ENOG4105KME endoribonuclease L-psp C2U31_20740 ENOG4105DND Transcriptional regulator C2U31_20760 ENOG4105DP0 ferredoxin-NADP reductase C2U31_20770 ENOG4107RCV ABC transporter, permease C2U31_20775 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U31_20780 ENOG4105JN3 extra-cytoplasmic solute receptor family protein C2U31_20790 ENOG4108S2Y peptide Chain Release factor C2U31_20795 ENOG4105EUB pirin domain protein C2U31_20805 ENOG4105EQ1 Transcriptional regulator C2U31_20810 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U31_20815 ENOG4105CUX Signal transduction histidine kinase C2U31_20825 ENOG4105C5F glutamine synthetase C2U31_20830 ENOG4105CSA Coproporphyrinogen iii oxidase C2U31_20835 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C2U31_20840 ENOG4105BZU Histidine kinase C2U31_20845 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_20850 ENOG4105C1G acyl-Coa dehydrogenase C2U31_20860 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) C2U31_20865 ENOG4105DSJ YicC domain protein C2U31_20890 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C2U31_20900 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C2U31_20910 ENOG4108Z4U Ferredoxin C2U31_20920 ENOG4105C26 Dehydrogenase C2U31_20925 ENOG4108IQI permease C2U31_20930 ENOG4105FYV Amp nucleosidase C2U31_20935 ENOG4105K4H Nlp p60 protein C2U31_20940 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C2U31_20950 ENOG4105NQN cytochrome C C2U31_20955 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C2U31_20960 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) C2U31_20965 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C2U31_20975 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) C2U31_20990 ENOG4105CSP Major Facilitator Superfamily C2U31_20995 ENOG4105CDA abc transporter atp-binding protein C2U31_21000 ENOG4105E5Q amino acid AbC transporter C2U31_21005 ENOG4107R0W ABC transporter C2U31_21025 ENOG4105E09 nadh pyrophosphatase C2U31_21040 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C2U31_21045 ENOG4108Z9W Outer membrane porin C2U31_21050 ENOG4108IV0 ABC, transporter C2U31_21055 ENOG4105C0Z ABC transporter C2U31_21060 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane C2U31_21065 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_21075 ENOG4105CFM UPF0317 protein C2U31_21080 ENOG4105DND Transcriptional regulator C2U31_21095 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C2U31_21110 ENOG4105DND Transcriptional regulator C2U31_21120 ENOG4105RKW reductase (By C2U31_21125 ENOG4105EAC phosphoserine phosphatase C2U31_21130 ENOG4105ETT transcriptional Regulator, LysR family C2U31_21135 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U31_21140 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component C2U31_21150 ENOG4108I0Y (ABC) transporter C2U31_21155 ENOG4108UJV acyl-CoA thioesterase i C2U31_21160 ENOG4105EIN peptidylprolyl cis-trans isomerase C2U31_21170 ENOG4107T6V glycerophosphoryl diester phosphodiesterase C2U31_21175 ENOG4105D6S protein involved in catabolism of external DNA C2U31_21180 ENOG4105ETT transcriptional Regulator, LysR family C2U31_21185 ENOG4105E32 cytoplasmic protein C2U31_21190 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U31_21200 ENOG4105EHV domain protein C2U31_21220 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C2U31_21240 ENOG4108K5P (LipO)protein C2U31_21245 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) C2U31_21250 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) C2U31_21255 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C2U31_21260 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C2U31_21265 ENOG4105C7N Xanthine uracil vitamin C permease C2U31_21270 ENOG4105DEN Luciferase family C2U31_21275 ENOG41080RH Thioredoxin C2U31_21305 ENOG4105F9N Major Facilitator Superfamily C2U31_21310 ENOG4105C5H ABC transporter C2U31_21315 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C2U31_21320 ENOG4108Z6B deaminase C2U31_21325 ENOG4106TCE C2U31_21335 ENOG4105KJM monovalent cation h antiporter subunit g C2U31_21340 ENOG4105W4C monovalent cation H antiporter subunit F C2U31_21345 ENOG4105SC1 monovalent cation H antiporter subunit E C2U31_21350 ENOG4107R4Z monovalent cation h antiporter subunit d C2U31_21355 ENOG4108ZE9 Monovalent cation H antiporter subunit C C2U31_21360 ENOG4105D65 subunit l C2U31_21390 ENOG4107RH8 nuclease SbcCD subunit D C2U31_21395 ENOG4105MWK D-amino acid dehydrogenase, small subunit C2U31_21400 ENOG4105EW9 transcriptional regulator AsnC family C2U31_21425 ENOG4105C1G acyl-Coa dehydrogenase C2U31_21445 ENOG4108Z9W Outer membrane porin C2U31_21450 ENOG4108Z9W Outer membrane porin C2U31_21475 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component C2U31_21485 ENOG4108IJ9 (ABC) transporter C2U31_21490 ENOG4108IJ9 (ABC) transporter C2U31_21495 ENOG4105E98 transcriptional regulator DeoR family C2U31_21510 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C2U31_21525 ENOG4108KXH Ybak prolyl-tRNA synthetase associated C2U31_21550 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C2U31_21560 ENOG4108YZN class I peptide chain release factor C2U31_21565 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C2U31_21580 ENOG4105DSW Fusaric acid resistance protein C2U31_21585 ENOG4105ZQC membrane protein AaeX C2U31_21590 ENOG4105Y49 secretion protein, HlyD family C2U31_21615 ENOG4105C0Z ABC transporter C2U31_21620 ENOG4108IV0 ABC, transporter C2U31_21625 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2U31_21635 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) C2U31_21645 ENOG4105C26 Dehydrogenase C2U31_21660 ENOG4106KED esterase YpfH C2U31_21665 ENOG4108IQI permease C2U31_21670 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) C2U31_21675 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C2U31_21680 ENOG4108MGI Transcriptional regulator C2U31_21685 ENOG4105WCN acetyltransferase C2U31_21690 ENOG4108KF1 Membrane C2U31_21720 ENOG4108ZX5 transcriptional regulator C2U31_21730 ENOG4105CHR reductase C2U31_21735 ENOG4105CUB amino acid C2U31_21740 ENOG4108JPW Aminotransferase C2U31_21770 ENOG4105C0B DNA polymerase III (alpha subunit) C2U31_21800 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C2U31_21815 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein C2U31_21820 ENOG4108IV0 ABC, transporter C2U31_21825 ENOG4105C0Z ABC transporter C2U31_21830 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_21855 ENOG4108FUF Transcriptional regulator, IclR family C2U31_21870 ENOG4105CPC Aldo Keto reductase C2U31_21875 ENOG4105PF9 Transcriptional regulator C2U31_21895 ENOG4105EWC Purine nucleoside phosphorylase C2U31_21905 ENOG4105R1U AraC Family Transcriptional Regulator C2U31_21920 ENOG4107R0U MotA TolQ exbB proton channel C2U31_21925 ENOG4105ER2 Ompa motb domain protein C2U31_21930 ENOG4105GRZ Ycii-related protein C2U31_21945 ENOG4105GRZ Ycii-related protein C2U31_21955 ENOG4105CHP RNA polymerase C2U31_21960 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C2U31_21965 ENOG4105DXC membrane C2U31_21995 ENOG4105EGI Transcriptional regulator C2U31_22000 ENOG410849A acetyltransferase, (GNAT) family C2U31_22010 ENOG41082F9 transcriptional regulator C2U31_22060 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C2U31_22070 ENOG4108TGY Glutathione S-transferase C2U31_22075 ENOG4106BRA Membrane C2U31_22085 ENOG4105E5Q amino acid AbC transporter C2U31_22090 ENOG4105E5Q amino acid AbC transporter C2U31_22130 ENOG4105CBN LysR family transcriptional regulator C2U31_22140 ENOG4105CHU acetyl-coa acetyltransferase C2U31_22145 ENOG4105CC9 acyl-Coa dehydrogenase C2U31_22150 ENOG4105C1G acyl-Coa dehydrogenase C2U31_22155 ENOG4105CEY Amp-dependent synthetase and ligase C2U31_22160 ENOG4105JN3 extra-cytoplasmic solute receptor family protein C2U31_22165 ENOG4105D01 (LipO)protein C2U31_22185 ENOG4108KSA LysR family transcriptional regulator C2U31_22225 ENOG4105F7P transcriptional regulator AsnC family C2U31_22230 ENOG4108Z9W Outer membrane porin C2U31_22235 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U31_22240 ENOG4105C4Y ABC transporter C2U31_22245 ENOG4105E0C molybdate abc transporter C2U31_22255 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C2U31_22260 ENOG4105CBS Chea signal transduction histidine kinase C2U31_22270 ENOG4108KTQ Methyltransferase C2U31_22280 ENOG4108W2P Methyl-accepting chemotaxis C2U31_22285 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2U31_22290 ENOG4105HEI LysR family (Transcriptional regulator C2U31_22310 ENOG4105F2V VRR-NUC domain-containing protein C2U31_22325 ENOG4105CHU acetyl-coa acetyltransferase C2U31_22330 ENOG4105C1G acyl-Coa dehydrogenase C2U31_22340 ENOG410900P UPF0336 protein C2U31_22355 ENOG4105CHR reductase C2U31_22360 ENOG4105DXM phenylacetic acid degradation protein C2U31_22380 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C2U31_22385 ENOG4105CGU Enoyl-CoA hydratase C2U31_22395 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) C2U31_22400 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase C2U31_22410 ENOG4105DDW LysR family Transcriptional regulator C2U31_22425 ENOG4105CEY Amp-dependent synthetase and ligase C2U31_22430 ENOG4105C57 major facilitator superfamily C2U31_22445 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) C2U31_22460 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C2U31_22475 ENOG4105KME endoribonuclease L-psp C2U31_22500 ENOG4108UQ8 endoribonuclease L-psp C2U31_22535 ENOG4105N14 lysine exporter protein LysE YggA C2U31_22550 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C2U31_22580 ENOG4106KE4 Dehydrogenase C2U31_22585 ENOG4108IND Tetr family transcriptional regulator C2U31_22610 ENOG4105CSU acyl-Coa dehydrogenase C2U31_22630 ENOG41083KI ribonuclease, T2 C2U31_22640 ENOG4105EMU Dehydrogenase C2U31_22645 ENOG4105ECQ AraC Family Transcriptional Regulator C2U31_22660 ENOG4105JSC dimethylmenaquinone methyltransferase C2U31_22665 ENOG4108JQ1 Dehydrogenase C2U31_22670 ENOG4105G3Z GntR family transcriptional regulator C2U31_22725 ENOG4105JQZ Methyltransferase C2U31_22735 ENOG4105WAB arsR family transcriptional regulator C2U31_22760 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme C2U31_22770 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) C2U31_22805 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C2U31_22810 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C2U31_22830 ENOG4105DQE DNA ligase C2U31_22835 ENOG4108M8H domain protein C2U31_22840 ENOG4105BZU Histidine kinase C2U31_22855 ENOG4105E1J oxidoreductase C2U31_22860 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U31_22865 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U31_22875 ENOG4108JQ7 (ABC) transporter C2U31_22880 ENOG4105DEF Extracellular solute-binding protein, family 5 C2U31_22945 ENOG4106YJS accessory processing protein C2U31_22955 ENOG4105CD3 dihydroorotase C2U31_23010 ENOG4108W5M transcriptional regulator C2U31_23020 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2U31_23030 ENOG4105CSH Transporter C2U31_23095 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C2U31_23110 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) C2U31_23115 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_23135 ENOG4108ETH Formylglycinamide ribotide synthetase C2U31_23145 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C2U31_23150 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C2U31_23175 ENOG4105BZ1 (ABC) transporter C2U31_23190 ENOG4108JJ7 ABC transporter C2U31_23195 ENOG4108NIW Leucine export protein LeuE C2U31_23200 ENOG4105EW9 transcriptional regulator AsnC family C2U31_23230 ENOG4105CEY Amp-dependent synthetase and ligase C2U31_23235 ENOG4105FDP GntR family transcriptional regulator C2U31_23255 ENOG4105CBN LysR family transcriptional regulator C2U31_23260 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C2U31_23275 ENOG4105E39 Enoyl-CoA hydratase C2U31_23280 ENOG4105BZU Histidine kinase C2U31_23290 ENOG4105C01 Dihydroxy-acid dehydratase C2U31_23300 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C2U31_23310 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C2U31_23340 ENOG4105CH5 extracellular solute-binding protein, family 7 C2U31_23365 ENOG4108UAU isochorismatase C2U31_23400 ENOG4107RSM transcriptional regulator C2U31_23405 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C2U31_23440 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) C2U31_23445 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) C2U31_23450 ENOG41060IM Heme exporter protein C2U31_23465 ENOG4105DA4 cytochrome c-type biogenesis protein C2U31_23470 ENOG4107QX9 Thiol disulfide interChange protein C2U31_23475 ENOG4105KWW Biogenesis protein C2U31_23480 ENOG4108M1T Cytochrome c-type biogenesis protein C2U31_23490 ENOG4105T0Z Conserved Protein C2U31_23495 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C2U31_23505 ENOG4108Z4X TRANSCRIPTIONal C2U31_23510 ENOG4105F27 Major Facilitator C2U31_23525 ENOG4105DB1 molybdopterin oxidoreductase C2U31_23530 ENOG4106WHD Tetrathionate reductase C2U31_23535 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein C2U31_23545 ENOG4105EUB pirin domain protein C2U31_23550 ENOG4108RRZ Transcription elongation factor GreB C2U31_23555 ENOG4105DB7 PHP domain protein C2U31_23565 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C2U31_23575 ENOG4105DND Transcriptional regulator C2U31_23595 ENOG4106IPI cyclase, family C2U31_23610 ENOG4108K3Z AraC family transcriptional regulator C2U31_23615 ENOG4108EC8 DNA internalization-related competence protein ComEC C2U31_23620 ENOG4105DMF Dehydrogenase C2U31_23630 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic C2U31_23635 ENOG4108IPW abc transporter atp-binding protein C2U31_23640 ENOG4105CM4 permease protein C2U31_23645 ENOG4105DHS permease protein C2U31_23655 ENOG4105D05 Receptor C2U31_23660 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2U31_23665 ENOG410804D Sensor Signal Transduction Histidine Kinase C2U31_23670 ENOG4105D05 Receptor C2U31_23675 ENOG4105EYA deoxyribonuclease C2U31_23680 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C2U31_23695 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C2U31_23700 ENOG4105CSP Major Facilitator Superfamily C2U31_23710 ENOG410904N short-chain dehydrogenase reductase C2U31_23715 ENOG4105CRK lysyL-tRNA synthetase C2U31_23725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U31_23730 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit C2U31_23740 ENOG4105CHU acetyl-coa acetyltransferase C2U31_23745 ENOG4108IQE Amp-dependent synthetase and ligase C2U31_23750 ENOG4108IV0 ABC, transporter C2U31_23770 ENOG4105C0Z ABC transporter C2U31_23795 ENOG4108Z5K methylglyoxal synthase C2U31_23800 ENOG4105WVQ Fe-S assembly protein IscX C2U31_23805 ENOG4108ZIT Ferredoxin, 2FE-2S C2U31_23810 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB C2U31_23815 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) C2U31_23820 ENOG4108Z4V iron-sulfur cluster assembly C2U31_23825 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins C2U31_23830 ENOG4105C3J Cysteine desulfurase C2U31_23835 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family C2U31_23845 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C2U31_23850 ENOG4105CGF Aromatic amino acid aminotransferase C2U31_23855 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C2U31_23860 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C2U31_23865 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C2U31_23870 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C2U31_23875 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C2U31_23880 ENOG4108K0D peptidase, M48 C2U31_23885 ENOG4108TEB UPF0114 protein C2U31_23895 ENOG4105VEQ Cold shock protein C2U31_23905 ENOG4105VEQ Cold shock protein C2U31_23930 ENOG4105KME endoribonuclease L-psp C2U31_23940 ENOG4105EJC lysr family transcriptional regulator C2U31_23955 ENOG4108Q5F Tetr family transcriptional regulator C2U31_23975 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C2U31_23980 ENOG4105DS1 cytochrome b561 C2U31_23985 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) C2U31_24015 ENOG4105C26 Dehydrogenase C2U31_24020 ENOG4105C5F glutamine synthetase C2U31_24025 ENOG4108K3Z AraC family transcriptional regulator C2U31_24050 ENOG4105CHM Aminotransferase C2U31_24055 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) C2U31_24065 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) C2U31_24070 ENOG4105C5H ABC transporter C2U31_24085 ENOG4105PE1 Receptor C2U31_24100 ENOG4105C4R Atp-dependent dna helicase C2U31_24125 ENOG4108V3E phosphoribosylglycinamide formyltransferase C2U31_24130 ENOG4105DTN riboflavin biosynthesis protein ribF C2U31_24135 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C2U31_24140 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C2U31_24145 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C2U31_24155 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) C2U31_24165 ENOG41068CG regulatoR C2U31_24185 ENOG4108VEV chaperone C2U31_24190 ENOG4105CW0 outer membrane usher protein C2U31_24195 ENOG4105GQR Chaperone C2U31_24225 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C2U31_24255 ENOG4105CIF Ornithine Cyclodeaminase C2U31_24260 ENOG4108Z9K Osmotically inducible protein C2U31_24265 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C2U31_24280 ENOG4105DCM major facilitator superfamily C2U31_24290 ENOG4108IG5 Transcriptional regulator C2U31_24295 ENOG4108IV0 ABC, transporter C2U31_24300 ENOG4105C0Z ABC transporter C2U31_24305 ENOG4105CF8 branched-chain amino acid ABC transporter, permease C2U31_24310 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_24320 ENOG4105C26 Dehydrogenase C2U31_24330 ENOG4105DY2 Paraquat-inducible protein b C2U31_24335 ENOG4105F1S paraquat-inducible protein a C2U31_24340 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C2U31_24345 ENOG4108JQB penicillin-binding protein 1C C2U31_24350 ENOG4105DN3 alpha-2-macroglobulin domain protein C2U31_24355 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) C2U31_24360 ENOG4105VEQ Cold shock protein C2U31_24370 ENOG4105CHU acetyl-coa acetyltransferase C2U31_24375 ENOG4105CMQ Chloride channel C2U31_24380 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_24385 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C2U31_24395 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C2U31_24410 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) C2U31_24420 ENOG4105W49 UPF0434 protein C2U31_24425 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) C2U31_24430 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C2U31_24440 ENOG4105CJR Integral membrane protein (MviN C2U31_24450 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) C2U31_24455 ENOG4105RQF LysR family Transcriptional regulator C2U31_24460 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C2U31_24465 ENOG4105CNV Aldolase C2U31_24480 ENOG4107YCY Transcriptional regulator C2U31_24495 ENOG4105DXI Major Facilitator superfamily C2U31_24500 ENOG4107QN1 sodium solute C2U31_24510 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C2U31_24515 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein C2U31_24520 ENOG4107QSA Oxaloacetate decarboxylase C2U31_24530 ENOG4105C5I Dehydrogenase C2U31_24545 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C2U31_24555 ENOG4105K56 Transcriptional regulator C2U31_24560 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase C2U31_24565 ENOG4105C26 Dehydrogenase C2U31_24585 ENOG4105CNV Aldolase C2U31_24590 ENOG4105CHR reductase C2U31_24595 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C2U31_24610 ENOG4107S11 squalene-associated FAD-dependent desaturase C2U31_24615 ENOG4108ARY Protein CrcB homolog C2U31_24635 ENOG4105CJ2 (LipO)protein C2U31_24640 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C2U31_24655 ENOG4107RSM transcriptional regulator C2U31_24670 ENOG4105EQN UPF0261 protein C2U31_24700 ENOG4105DRR Transcriptional regulator, GntR family C2U31_24705 ENOG4105MP9 class II Aldolase C2U31_24710 ENOG4105DEF Extracellular solute-binding protein, family 5 C2U31_24735 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase C2U31_24745 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C2U31_24755 ENOG4105DS0 Transcriptional regulator, Crp Fnr family C2U31_24765 ENOG4105CSH Transporter C2U31_24775 ENOG4108YZ4 nudix hydrolase C2U31_24790 ENOG4105R8A Heat shock protein C2U31_24800 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C2U31_24805 ENOG41068CG regulatoR C2U31_24810 ENOG4105D4P Coproporphyrinogen iii oxidase C2U31_24830 ENOG4105C7K acetolactate synthase C2U31_24835 ENOG4105CE7 Amidase, hydantoinase carbamoylase family C2U31_24840 ENOG4105C26 Dehydrogenase C2U31_24845 ENOG4107S4Y M20 DapE family protein YgeY C2U31_24855 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U31_24860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U31_24865 ENOG4108JQ6 ABC transporter C2U31_24870 ENOG4105K8K Cupin 2, conserved barrel C2U31_24885 ENOG4105DIQ Transcriptional regulator C2U31_24890 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter C2U31_24895 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C2U31_24900 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C2U31_24905 ENOG4105C01 Dihydroxy-acid dehydratase C2U31_24915 ENOG4105BZU Histidine kinase C2U31_24950 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase C2U31_24955 ENOG4105CH5 extracellular solute-binding protein, family 7 C2U31_24960 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C2U31_24970 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C2U31_24975 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C2U31_24980 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C2U31_24985 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C2U31_24990 ENOG4105DFG type I secretion outer membrane protein C2U31_25000 ENOG4108JJA ABC, transporter C2U31_25030 ENOG4107R11 Transcriptional regulator C2U31_25035 ENOG4107YUH hydrolase C2U31_25045 ENOG4105ERG peptidase m48, ste24p C2U31_25050 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C2U31_25055 ENOG4105BZU Histidine kinase C2U31_25065 ENOG4105BZU Histidine kinase C2U31_25075 ENOG4105CNG UPF0061 protein C2U31_25085 ENOG4107S2Z UPF0761 membrane protein C2U31_25095 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C2U31_25160 ENOG41082BM Transcriptional regulator, arsr family C2U31_25165 ENOG4105EXC Acyl-transferase C2U31_25170 ENOG4105ECQ AraC Family Transcriptional Regulator C2U31_25175 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) C2U31_25185 ENOG4105JJR Histidine kinase C2U31_25195 ENOG4106F60 Histidine kinase C2U31_25220 ENOG4108Z9W Outer membrane porin C2U31_25230 ENOG41061N2 exported protein C2U31_25235 ENOG4105K5X acetyltransferase C2U31_25295 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2U31_25305 ENOG4105VCC 30S ribosomal protein S21 C2U31_25315 ENOG4108M60 Transcriptional regulator C2U31_25320 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C2U31_25325 ENOG4105DE4 1-phosphofructokinase C2U31_25330 ENOG4105DM4 PTS System C2U31_25335 ENOG4105EQR Transposase IS116 IS110 IS902 C2U31_25340 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C2U31_25345 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) C2U31_25350 ENOG4105EPW hflc protein C2U31_25355 ENOG4107QJR hflk protein C2U31_25360 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C2U31_25365 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C2U31_25375 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C2U31_25380 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) C2U31_25385 ENOG4105N21 Membrane C2U31_25390 ENOG4105CUT histidyl-tRNA synthetase C2U31_25395 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C2U31_25405 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C2U31_25410 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C2U31_25415 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C2U31_25420 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C2U31_25425 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) C2U31_25430 ENOG4105K5M 30s ribosomal protein S16 C2U31_25435 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) C2U31_25440 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C2U31_25455 ENOG4105MWK D-amino acid dehydrogenase, small subunit C2U31_25465 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) C2U31_25470 ENOG4105KPY Small multidrug resistance protein C2U31_25475 ENOG4105QVC MOSC domain-containing protein C2U31_25480 ENOG4105EV8 ectoine hydroxylase C2U31_25485 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) C2U31_25490 ENOG4108JPW Aminotransferase C2U31_25495 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase C2U31_25510 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C2U31_25525 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2U31_25535 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2U31_25540 ENOG4105K63 Thioredoxin C2U31_25545 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C2U31_25565 ENOG4105DF6 Fe-S oxidoreductase C2U31_25570 ENOG4105C10 Electron transfer flavoprotein C2U31_25580 ENOG4105DVW rieske (2Fe-2S) C2U31_25590 ENOG4105ECQ AraC Family Transcriptional Regulator C2U31_25600 ENOG4105C94 Transporter C2U31_25610 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase C2U31_25635 ENOG4108RXX maleylacetoacetate isomerase C2U31_25640 ENOG4105CSH Transporter C2U31_25655 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) C2U31_25660 ENOG4105WPN DNA integration recombination invertion protein C2U31_25705 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein C2U31_25710 ENOG4108RNG Permease of the drug metabolite transporter C2U31_25720 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes C2U31_25730 ENOG4105CW7 secretion protein, HlyD family C2U31_25735 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2U31_25745 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C2U31_25750 ENOG4105D7A ATP-binding protein C2U31_25755 ENOG4105CDY transcriptional regulatory protein C2U31_25760 ENOG4105C12 Phosphoribosylglycinamide synthetase C2U31_25765 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) C2U31_25770 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C2U31_25775 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) C2U31_25780 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C2U31_25785 ENOG4108Z03 MAF-like protein C2U31_25790 ENOG4105CK2 sodium dicarboxylate symporter C2U31_25800 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U31_25810 ENOG4105JQN Transcriptional regulator C2U31_25815 ENOG4107QM5 aconitate hydratase C2U31_25820 ENOG4105UYK outer membrane protein a C2U31_25825 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b C2U31_25840 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C2U31_25855 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U31_25930 ENOG4105BZU Histidine kinase C2U31_25950 ENOG4108JQ6 ABC transporter C2U31_25955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2U31_25975 ENOG4105D7N magnesium and cobalt transport protein CorA C2U31_25995 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C2U31_26020 ENOG4108JPW Aminotransferase C2U31_26025 ENOG4105C26 Dehydrogenase C2U31_26030 ENOG4105ECY inositol monophosphatase C2U31_26035 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C2U31_26040 ENOG4105D7W serine acetyltransferase C2U31_26045 ENOG4107QP8 phosphohexose isomerase C2U31_26050 ENOG4107QKV phosphomannomutase C2U31_26065 ENOG4105D3Q Sugar transferase C2U31_26070 ENOG4105FGF GDP-mannose mannosyl hydrolase C2U31_26075 ENOG4105CJT Mannose-1-phosphate guanylyltransferase C2U31_26110 ENOG4107T8Q Glycosyl transferase (Group 1 C2U31_26115 ENOG4106WTF Glycosyl transferase, family 2 C2U31_26120 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF C2U31_26125 ENOG4106CD9 glycosyl transferase group 1 C2U31_26130 ENOG4105WH1 Two component transcriptional regulator luxr family C2U31_26135 ENOG4105WH1 Two component transcriptional regulator luxr family C2U31_26150 ENOG4107QPN acyl-Coa dehydrogenase C2U31_26155 ENOG4105CHU acetyl-coa acetyltransferase C2U31_26160 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C2U31_26175 ENOG4105CHU acetyl-coa acetyltransferase C2U31_26190 ENOG4105CEY Amp-dependent synthetase and ligase C2U31_26210 ENOG4105BZ1 (ABC) transporter C2U31_26215 ENOG4105CEY Amp-dependent synthetase and ligase C2U31_26230 ENOG4105CGU Enoyl-CoA hydratase C2U31_26250 ENOG4105J4Q Transcriptional regulator C2U31_26255 ENOG4108T2C cysteine dioxygenase type I C2U31_26260 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C2U31_26280 ENOG4105DUM transcriptional regulator, lysR family C2U31_26290 ENOG4105KD7 acetyltransferase C2U31_26320 ENOG4105CFH Aspartokinase C2U31_26325 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C2U31_26330 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) C2U31_26340 ENOG4105C8N cysteinyl-tRNA synthetase C2U31_26350 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) C2U31_26355 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) C2U31_26360 ENOG4105EUR Domain-Containing protein C2U31_26360 ENOG4105EUR Domain-Containing protein C2U31_26365 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C2U31_26370 ENOG4105EE5 Membrane protein terC C2U31_26375 ENOG4105EE5 Membrane protein terC C2U31_26380 ENOG4105HEE Binding Domain protein C2U31_26385 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) C2U31_26395 ENOG4105CIG ABC transporter C2U31_26400 ENOG4108T0W nitrous oxide maturation protein NosY C2U31_26415 ENOG4105ECY inositol monophosphatase C2U31_26420 ENOG4105CVS RNA methyltransferase TrmH family, group 1 C2U31_26440 ENOG4105D64 Mechanosensitive ion channel C2U31_26475 ENOG4108YYH Nadph-dependent fmn reductase C2U31_26485 ENOG4105WKW Pfam:DUF1458 C2U31_26495 ENOG4105HEI LysR family (Transcriptional regulator C2U31_26500 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C2U31_26615 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) C2U31_26620 ENOG4105EZE Cupin 4 family protein C2U31_26630 ENOG4105GJM (LipO)protein C2U31_26635 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2U31_26640 ENOG4108Z4T Peptidase M50 C2U31_26645 ENOG4107RTD sua5 ycio yrdc ywlc family protein C2U31_26650 ENOG4105CGZ zinc metallopeptidase C2U31_26700 ENOG4105RHY Pfam:UPF0157 C2U31_26730 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C2U31_26735 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C2U31_26760 ENOG4105C0H protease C2U31_26765 ENOG4107SQD Transcriptional regulator, GntR family C2U31_26795 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) C2U31_26800 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C2U31_26815 ENOG4105CT3 Monooxygenase C2U31_26845 ENOG4105DRP amino acid AbC transporter C2U31_26855 ENOG4105F87 Dehydratase C2U31_26860 ENOG4105CDA abc transporter atp-binding protein C2U31_26865 ENOG4105C26 Dehydrogenase C2U31_26870 ENOG4105HDD phospholipase C2U31_26875 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) C2U31_26890 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C2U31_26915 ENOG4105SG9 biopolymer transport protein, ExbD C2U31_26920 ENOG4105E02 MotA TolQ exbB proton channel C2U31_26965 ENOG4108S8N class II Aldolase C2U31_26990 ENOG4107Z3H Transcriptional regulator, TetR family C2U31_27000 ENOG4105G6Z alkaline phosphatase C2U31_27060 ENOG4105DUM transcriptional regulator, lysR family C2U31_27080 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_27090 ENOG4108IUZ ABC transporter C2U31_27095 ENOG4108IV0 ABC, transporter C2U31_27105 ENOG4105CAU Arsenical resistance protein, ArsH C2U31_27110 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2U31_27115 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2U31_27120 ENOG4105XPH Ferredoxin C2U31_27130 ENOG4105X1Z Methyltransferase type 12 C2U31_27135 ENOG4105CHM Aminotransferase C2U31_27140 ENOG4105C8Y Acetylornithine aminotransferase C2U31_27185 ENOG4105D8X mechanosensitive ion channel C2U31_27190 ENOG4107EXC regulatoR C2U31_27205 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C2U31_27210 ENOG4105BZS acriflavin resistance protein C2U31_27215 ENOG4105C1P efflux transporter, rnd family, mfp subunit C2U31_27220 ENOG4105RJZ Transcriptional regulator C2U31_27225 ENOG4108JPW Aminotransferase C2U31_27265 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C2U31_27280 ENOG4105EB3 Histidine kinase C2U31_27285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2U31_27305 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U31_27310 ENOG4105ECW sulfate abc transporter C2U31_27315 ENOG4105SKE transcriptional Regulator LysR family C2U31_27320 ENOG4108SF5 RNA Polymerase C2U31_27325 ENOG4108S3W Anti-feci sigma factor, fecr C2U31_27330 ENOG4105E0K tonB-dependent siderophore receptor C2U31_27340 ENOG4107V59 shikimate C2U31_27345 ENOG4108IUS Transketolase C2U31_27350 ENOG4108HHA Transketolase C2U31_27355 ENOG4108WYP Transcriptional regulator C2U31_27360 ENOG4105DCT glycerol dehydrogenase C2U31_27365 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C2U31_27375 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_27380 ENOG4105C0Z ABC transporter C2U31_27385 ENOG4108IV0 ABC, transporter C2U31_27395 ENOG4105CHR reductase C2U31_27410 ENOG4105MWK D-amino acid dehydrogenase, small subunit C2U31_27420 ENOG4105FQ6 thiopurine methyltransferase C2U31_27425 ENOG4105EMN RNA polymerase sigma factor C2U31_27455 ENOG4105CPC Aldo Keto reductase C2U31_27460 ENOG4105CF7 AraC family transcriptional regulator C2U31_27470 ENOG4105E5Q amino acid AbC transporter C2U31_27480 ENOG4105CDA abc transporter atp-binding protein C2U31_27490 ENOG4105M4H endoribonuclease L-psp C2U31_27500 ENOG4105K2J Transcriptional regulator C2U31_27505 ENOG4105HEI LysR family (Transcriptional regulator C2U31_27510 ENOG4105CHJ isochorismatase hydrolase C2U31_27545 ENOG4105CC0 LysR family Transcriptional regulator C2U31_27550 ENOG4105F27 Major Facilitator C2U31_27590 ENOG4107QWB Ornithine cyclodeaminase C2U31_27605 ENOG4105BZU Histidine kinase C2U31_27610 ENOG41080V3 Major Facilitator superfamily C2U31_27625 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C2U31_27630 ENOG4105CSH Transporter C2U31_27640 ENOG4107RSM transcriptional regulator C2U31_27650 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C2U31_27655 ENOG4105E2Z phosphate ABC transporter (Permease C2U31_27660 ENOG4105C8U phosphate abc transporter C2U31_27665 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) C2U31_27675 ENOG4105C9X ppx gppa phosphatase C2U31_27685 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C2U31_27695 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C2U31_27700 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) C2U31_27705 ENOG4105HBR Rna-binding protein C2U31_27710 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C2U31_27715 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_27720 ENOG4105C2W permease C2U31_27740 ENOG4107FW0 short-chain dehydrogenase reductase C2U31_27750 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C2U31_27755 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C2U31_27760 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) C2U31_27770 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C2U31_27780 ENOG4105D2X ABC transporter substrate-binding protein C2U31_27785 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C2U31_27790 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C2U31_27800 ENOG4107QMP dna polymerase iii subunits gamma and tau C2U31_27820 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation C2U31_27840 ENOG41061WM D-Alanyl-D-Alanine C2U31_27860 ENOG4108Z66 YbaK ebsC protein C2U31_27865 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2U31_27870 ENOG4105ETT transcriptional Regulator, LysR family C2U31_27875 ENOG4105C7K acetolactate synthase C2U31_27880 ENOG4105C1G acyl-Coa dehydrogenase C2U31_27890 ENOG4105DJG MaoC domain protein dehydratase C2U31_27900 ENOG4105CDA abc transporter atp-binding protein C2U31_27905 ENOG4105E5Q amino acid AbC transporter C2U31_27910 ENOG4106TNF Periplasmic binding protein C2U31_27915 ENOG4105CYW agmatinase C2U31_27920 ENOG41069M3 Transcriptional regulator C2U31_27965 ENOG4105ETT transcriptional Regulator, LysR family C2U31_27970 ENOG4105CYC Transferase C2U31_27975 ENOG4105CMU LysR family (Transcriptional regulator C2U31_27980 ENOG4105EGS Mechanosensitive ion channel C2U31_28010 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C2U31_28020 ENOG4107SDU Methyl-accepting chemotaxis C2U31_28035 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2U31_28040 ENOG4105F38 ABC transporter, permease C2U31_28050 ENOG4105CTU Proline racemase C2U31_28055 ENOG41080XP Cbs domain C2U31_28075 ENOG4107QIJ Aconitate hydratase 2 C2U31_28080 ENOG4105ZRN C2U31_28095 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C2U31_28100 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C2U31_28105 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C2U31_28110 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) C2U31_28115 ENOG4105C8V SAICAR synthetase C2U31_28135 ENOG4105CK2 sodium dicarboxylate symporter C2U31_28150 ENOG4105FD8 phosphonate metabolism protein PhnM C2U31_28155 ENOG4105HRV phosphonate c-p lyase system protein phnl C2U31_28160 ENOG4105ENV phosphonate C-P lyase system protein PhnK C2U31_28165 ENOG4105FT8 Phosphonate metabolism C2U31_28180 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG C2U31_28185 ENOG4107RJJ Transcriptional regulator C2U31_28190 ENOG4105FD8 phosphonate metabolism protein PhnM C2U31_28195 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) C2U31_28200 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) C2U31_28205 ENOG410811B TRANSCRIPTIONal C2U31_28215 ENOG4108C33 Resolvase C2U31_28245 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C2U31_28265 ENOG4105EHI Phosphonate ABC transporter, periplasmic C2U31_28270 ENOG4105D5T phosphonate abc transporter C2U31_28290 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) C2U31_28300 ENOG4105DR5 peptidase C2U31_28310 ENOG4108RIR Molybdenum cofactor biosynthesis protein C2U31_28315 ENOG4105CJ3 phosphate transporter C2U31_28345 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) C2U31_28355 ENOG4108SHQ Glutathione S-transferase C2U31_28375 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C2U31_28380 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C2U31_28390 ENOG4105BZA Phosphoglycerate kinase C2U31_28395 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C2U31_28400 ENOG4105CV1 Transketolase (EC 2.2.1.1) C2U31_28410 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C2U31_28425 ENOG4105C6K Malic enzyme C2U31_28440 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division C2U31_28445 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) C2U31_28480 ENOG4105TNS Conserved Protein C2U31_28490 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) C2U31_28500 ENOG4108IFG nitrite reductase, (NAD(P)H) C2U31_28505 ENOG4105D7T ABC transporter C2U31_28515 ENOG4105I5W Transporter C2U31_28525 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C2U31_28530 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C2U31_28535 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase C2U31_28560 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C2U31_28565 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) C2U31_28570 ENOG4105VIE preprotein translocase, subunit YajC C2U31_28575 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C2U31_28580 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C2U31_28605 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C2U31_28615 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C2U31_28620 ENOG4105C9A Phoh family C2U31_28625 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C2U31_28630 ENOG4108JU5 Magnesium and cobalt efflux protein C2U31_28635 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) C2U31_28640 ENOG4107SET aldo keto reductase C2U31_28675 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C2U31_28680 ENOG4108TZV Membrane C2U31_28700 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) C2U31_28710 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C2U31_28720 ENOG4108ZAF Molybdopterin C2U31_28725 ENOG4108RIR Molybdenum cofactor biosynthesis protein C2U31_28730 ENOG4105CVM Molybdenum cofactor synthesis domain protein C2U31_28735 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) C2U31_28740 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C2U31_28755 ENOG4107QIZ NADH dehydrogenase C2U31_28760 ENOG4108IEG Formate dehydrogenase Alpha subunit C2U31_28765 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C2U31_28785 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C2U31_28805 ENOG4106NZI LysR family Transcriptional regulator C2U31_28810 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C2U31_28815 ENOG41068KF Universal stress protein C2U31_28830 ENOG4105XJC Two component transcriptional regulator (Winged helix family C2U31_28845 ENOG4105E3J oxidoreductase C2U31_28855 ENOG4105CHR reductase C2U31_28870 ENOG4105JN3 extra-cytoplasmic solute receptor family protein C2U31_28875 ENOG4105C7F AcnD-accessory protein PrpF C2U31_28880 ENOG4105F04 LysR family Transcriptional regulator C2U31_28885 ENOG41080E2 ribosomal-protein-alanine acetyltransferase C2U31_28920 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein C2U31_28925 ENOG4105C32 Amino acid ABC transporter (Permease) C2U31_28935 ENOG4105C0Z ABC transporter C2U31_28940 ENOG4108IV0 ABC, transporter C2U31_28950 ENOG4105E0K tonB-dependent siderophore receptor C2U31_28970 ENOG4108XG2 Histidine kinase C2U31_28975 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C2U31_28980 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C2U31_28985 ENOG4105D03 DNA-3-methyladenine glycosylase II C2U31_28990 ENOG4108VPT UPF0234 protein C2U31_29000 ENOG4105EHG Permease protein C2U31_29005 ENOG4107R4I Periplasmic binding protein C2U31_29010 ENOG4106QJH hemin transport protein C2U31_29020 ENOG4108S3W Anti-feci sigma factor, fecr C2U31_29025 ENOG4108SF5 RNA Polymerase C2U31_29040 ENOG4105D29 Helix-turn-helix type 11 domain protein C2U31_29065 ENOG4105EXG Transcriptional regulator C2U31_29070 ENOG4105C85 amino acid C2U31_29080 ENOG4105F7P transcriptional regulator AsnC family C2U31_29085 ENOG4108UT2 hemolysin iii C2U31_29090 ENOG4105KXX peptidase s58 dmpa C2U31_29095 ENOG4105EAB amino acid AbC transporter C2U31_29100 ENOG4105E5Q amino acid AbC transporter C2U31_29105 ENOG4105CDA abc transporter atp-binding protein C2U31_29130 ENOG4108K5P (LipO)protein C2U31_29150 ENOG4108ZX6 Electron transport protein SCO1 SenC C2U31_29165 ENOG4105TX3 Histidine kinase C2U31_29170 ENOG4108UYB regulatoR C2U31_29175 ENOG4105E2S oxidase) subunit II C2U31_29180 ENOG4105BZ9 Cytochrome C oxidase, subunit I C2U31_29185 ENOG4105CCU oxidase (Subunit III) C2U31_29190 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) C2U31_29230 ENOG4105C6K Malic enzyme C2U31_29245 ENOG4108PCN EamA-like transporter family C2U31_29265 ENOG4105CHR reductase C2U31_29270 ENOG4105D74 hydrolase C2U31_29290 ENOG4107RZC phospholipase d C2U31_29295 ENOG4105CF1 Alkylated DNA repair protein C2U31_29305 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C2U31_29310 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 C2U31_29335 ENOG4108IND Tetr family transcriptional regulator C2U31_29345 ENOG4105BZU Histidine kinase C2U31_29350 ENOG4105EPW hflc protein C2U31_29360 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase C2U31_29365 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2U31_29370 ENOG4108Z9W Outer membrane porin C2U31_29390 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C2U31_29395 ENOG4105DJ2 Major Facilitator Superfamily C2U31_29400 ENOG4105R1U AraC Family Transcriptional Regulator C2U31_29405 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) C2U31_29415 ENOG4105DU1 integral membrane protein, terc C2U31_29420 ENOG41063Z6 transcriptional regulator, lysR family C2U31_29450 ENOG41067B5 Histone deacetylase superfamily protein C2U31_29455 ENOG4105CSH Transporter C2U31_29460 ENOG4105E2S oxidase) subunit II C2U31_29465 ENOG4105BZ9 Cytochrome C oxidase, subunit I C2U31_29470 ENOG4105CCU oxidase (Subunit III) C2U31_29475 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) C2U31_29480 ENOG4108R6F Surfeit locus 1 family protein C2U31_29515 ENOG4108K3A Glutathione S-transferase C2U31_29540 ENOG4105BZU Histidine kinase C2U31_29545 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2U31_29550 ENOG4105BZU Histidine kinase C2U31_29555 ENOG41068CG regulatoR C2U31_29560 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) C2U31_29610 ENOG4105DC7 peptidase M24 C2U31_29615 ENOG4105DDW LysR family Transcriptional regulator C2U31_29625 ENOG4105CPC Aldo Keto reductase C2U31_29645 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_29650 ENOG4105C8Q Methyl-accepting chemotaxis C2U31_29655 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C2U31_29665 ENOG4107QM5 aconitate hydratase C2U31_29680 ENOG4107W9I Creatinine amidohydrolase C2U31_29695 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) C2U31_29700 ENOG4107S2N Type III effector Hrp-dependent C2U31_29705 ENOG4108MGI Transcriptional regulator C2U31_29715 ENOG4107RGD Major Facilitator superfamily C2U31_29730 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) C2U31_29740 ENOG4105FQP Beta-lactamase C2U31_29745 ENOG4107SQD Transcriptional regulator, GntR family C2U31_29750 ENOG4105T38 integral membrane protein C2U31_29805 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component C2U31_29810 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C2U31_29815 ENOG4105D7T ABC transporter C2U31_29820 ENOG4105CPU Monooxygenase C2U31_29850 ENOG4105JQN Transcriptional regulator C2U31_29870 ENOG41068CG regulatoR C2U31_29905 ENOG4108JQ6 ABC transporter C2U31_29920 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2U31_29925 ENOG4105DEF Extracellular solute-binding protein, family 5 C2U31_29970 ENOG4105EXG Transcriptional regulator C2U31_29995 ENOG4107RTG Major Facilitator superfamily C2U31_30015 ENOG4105CMJ mandelate racemase muconate lactonizing C2U31_30020 ENOG4105WH1 Two component transcriptional regulator luxr family C2U31_30025 ENOG4105BZU Histidine kinase C2U31_30030 ENOG4105DXI Major Facilitator superfamily C2U31_30050 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme C2U31_30055 ENOG4105FGE Short-chain dehydrogenase reductase Sdr C2U31_30115 ENOG410904A RNA polymerase C2U31_30125 ENOG4105DJ2 Major Facilitator Superfamily C2U31_30130 ENOG4107Y2X deaminase C2U31_30150 ENOG4105CXK mandelate racemase muconate lactonizing C2U31_30155 ENOG4108T2C cysteine dioxygenase type I C2U31_30175 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C2U31_30205 ENOG4106A3M Cytochrome p-450 C2U31_30225 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2U31_30230 ENOG4105CY2 Citrate transporter C2U31_30235 ENOG4105DTD Dehydrogenase C2U31_30265 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) C2U31_30270 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C2U31_30285 ENOG4105DEI Mannitol dehydrogenase C2U31_30290 ENOG41080IJ Diacylglycerol kinase C2U31_30295 ENOG4105CEP NADH dehydrogenase C2U31_30300 ENOG4105SKN orotidine 5''-phosphate decarboxylase C2U31_30305 ENOG4107TH8 cina domain protein C2U31_30315 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C2U31_30320 ENOG4107YIM Involved in the transcription termination process (By similarity) C2U31_30325 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C2U31_30330 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)