locus-tag	class	description
C2U31_00015	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C2U31_00020	COG3639	organic phosphonate transmembrane transporter activity
C2U31_00025	COG3639	organic phosphonate transmembrane transporter activity
C2U31_00050	COG0742	ribosomal rna small subunit methyltransferase
C2U31_00055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2U31_00060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U31_00065	COG3135	benzoate transporter
C2U31_00095	COG0438	transferase activity, transferring glycosyl groups
C2U31_00100	COG0012	GTP binding
C2U31_00120	COG0193	aminoacyl-tRNA hydrolase activity
C2U31_00125	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2U31_00130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U31_00140	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2U31_00145	COG0840	transmembrane signaling receptor activity
C2U31_00150	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2U31_00160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2U31_00185	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C2U31_00195	COG0204	Acyl-transferase
C2U31_00200	COG1368	sulfuric ester hydrolase activity
C2U31_00205	COG2186	Transcriptional regulator
C2U31_00215	COG2205	protein histidine kinase activity
C2U31_00220	COG0745	RESPONSE REGULATOR receiver
C2U31_00225	COG0277	FAD linked oxidase domain protein
C2U31_00240	COG0166	Belongs to the GPI family
C2U31_00245	COG0438	transferase activity, transferring glycosyl groups
C2U31_00250	COG0438	transferase activity, transferring glycosyl groups
C2U31_00255	COG0438	transferase activity, transferring glycosyl groups
C2U31_00280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2U31_00285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U31_00290	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C2U31_00300	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C2U31_00315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_00335	COG0747	negative chemotaxis
C2U31_00340	COG0601	transmembrane transport
C2U31_00345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_00350	COG4172	Belongs to the ABC transporter superfamily
C2U31_00355	COG0154	amidase activity
C2U31_00390	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U31_00390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U31_00395	COG0509	glycine decarboxylation via glycine cleavage system
C2U31_00400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2U31_00415	COG2081	HI0933 family
C2U31_00420	COG1982	Orn Lys Arg decarboxylase major
C2U31_00430	COG0456	acetyltransferase
C2U31_00435	COG2203	Gaf domain
C2U31_00435	COG3706	GGDEF domain
C2U31_00435	COG4251	negative regulation of phosphorylation
C2U31_00435	COG5001	Diguanylate cyclase
C2U31_00445	COG0717	Belongs to the dCTP deaminase family
C2U31_00460	COG0489	protein tyrosine kinase activity
C2U31_00490	COG2755	lipolytic protein G-D-S-L family
C2U31_00490	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2U31_00500	COG0745	RESPONSE REGULATOR receiver
C2U31_00505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U31_00530	COG2200	EAL domain
C2U31_00550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_00555	COG0842	Transport permease protein
C2U31_00555	COG1129	ABC transporter
C2U31_00560	COG0842	Transport permease protein
C2U31_00570	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_00580	COG0697	spore germination
C2U31_00590	COG1271	oxidase subunit
C2U31_00595	COG1294	oxidase, subunit
C2U31_00605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_00610	COG3258	Cytochrome c
C2U31_00620	COG0625	glutathione transferase activity
C2U31_00665	COG0165	Argininosuccinate lyase
C2U31_00670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2U31_00680	COG0583	DNA-binding transcription factor activity
C2U31_00685	COG0235	Class ii aldolase
C2U31_00690	COG0477	Major facilitator Superfamily
C2U31_00730	COG0457	Tetratricopeptide repeat
C2U31_00735	COG0438	transferase activity, transferring glycosyl groups
C2U31_00740	COG1596	polysaccharide export
C2U31_00760	COG4783	chaperone-mediated protein folding
C2U31_00760	COG1560	Kdo2-lipid A biosynthetic process
C2U31_00765	COG3866	Pectate lyase
C2U31_00770	COG0583	DNA-binding transcription factor activity
C2U31_00775	COG2814	Major facilitator Superfamily
C2U31_00820	COG0583	DNA-binding transcription factor activity
C2U31_00825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U31_00875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U31_00885	COG0542	response to heat
C2U31_00890	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U31_00910	COG0583	DNA-binding transcription factor activity
C2U31_00925	COG1192	Involved in chromosome partitioning
C2U31_01105	COG3039	Transposase
C2U31_01180	COG2003	Belongs to the UPF0758 family
C2U31_01240	COG0582	viral genome integration into host DNA
C2U31_01280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_01285	COG0583	DNA-binding transcription factor activity
C2U31_01290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2U31_01310	COG1652	LysM domain
C2U31_01315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U31_01335	COG0625	glutathione transferase activity
C2U31_01340	COG1414	Transcriptional regulator
C2U31_01345	COG3734	2-keto-3-deoxy-galactonokinase
C2U31_01350	COG0800	Aldolase
C2U31_01355	COG4948	Mandelate Racemase Muconate Lactonizing
C2U31_01360	COG2271	Major facilitator Superfamily
C2U31_01365	COG2814	Major facilitator Superfamily
C2U31_01370	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C2U31_01375	COG1518	maintenance of DNA repeat elements
C2U31_01405	COG0326	Molecular chaperone. Has ATPase activity
C2U31_01420	COG2233	PERMEase
C2U31_01430	COG2026	Addiction module toxin, RelE StbE family
C2U31_01445	COG5499	transcription regulator containing HTH domain
C2U31_01450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_01455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U31_01475	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U31_01480	COG4605	iron ion homeostasis
C2U31_01485	COG4604	ABC transporter, ATP-binding protein
C2U31_01490	COG4607	ABC-type enterochelin transport system periplasmic component
C2U31_01495	COG4774	siderophore transport
C2U31_01585	COG3846	protein secretion by the type IV secretion system
C2U31_01600	COG3451	type IV secretory pathway VirB4
C2U31_01610	COG3838	Conjugal transfer protein Trbc
C2U31_01615	COG4962	Type ii secretion system protein e
C2U31_01645	COG2076	Multidrug Resistance protein
C2U31_01655	COG0583	DNA-binding transcription factor activity
C2U31_01690	COG2003	Belongs to the UPF0758 family
C2U31_01695	COG4804	nuclease activity
C2U31_01770	COG1695	Transcriptional regulator
C2U31_01790	COG0477	Major facilitator Superfamily
C2U31_01810	COG1090	epimerase
C2U31_01820	COG0628	permease
C2U31_01825	COG0583	DNA-binding transcription factor activity
C2U31_01830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_01855	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
C2U31_01880	COG2186	Transcriptional regulator
C2U31_01890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U31_01900	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_01910	COG0411	ABC transporter
C2U31_01920	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_01925	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2U31_01935	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U31_01940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U31_01945	COG0656	L-ascorbic acid biosynthetic process
C2U31_01950	COG0583	DNA-binding transcription factor activity
C2U31_01960	COG0667	Aldo Keto reductase
C2U31_01965	COG0583	DNA-binding transcription factor activity
C2U31_01975	COG0625	glutathione transferase activity
C2U31_01985	COG0129	dihydroxy-acid dehydratase activity
C2U31_02010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2U31_02015	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2U31_02020	COG1802	Transcriptional regulator
C2U31_02035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U31_02055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_02060	COG0778	Nitroreductase
C2U31_02070	COG0583	DNA-binding transcription factor activity
C2U31_02085	COG1595	DNA-templated transcription, initiation
C2U31_02090	COG3712	iron ion homeostasis
C2U31_02095	COG4774	siderophore transport
C2U31_02105	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_02110	COG2031	fatty acid transporter
C2U31_02115	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_02120	COG1414	Transcriptional regulator
C2U31_02130	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U31_02145	COG0596	Alpha beta hydrolase
C2U31_02165	COG0288	reversible hydration of carbon dioxide
C2U31_02210	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_02220	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_02255	COG0625	glutathione transferase activity
C2U31_02285	COG0583	DNA-binding transcription factor activity
C2U31_02310	COG1464	Belongs to the NlpA lipoprotein family
C2U31_02325	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U31_02330	COG1309	transcriptional regulator
C2U31_02335	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U31_02340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2U31_02345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2U31_02395	COG0583	DNA-binding transcription factor activity
C2U31_02405	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2U31_02415	COG1053	succinate dehydrogenase
C2U31_02435	COG1522	sequence-specific DNA binding
C2U31_02445	COG5006	permease, DMT superfamily
C2U31_02450	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_02455	COG3622	Belongs to the hyi family
C2U31_02490	COG0747	negative chemotaxis
C2U31_02495	COG0601	transmembrane transport
C2U31_02505	COG0444	Belongs to the ABC transporter superfamily
C2U31_02510	COG4608	Belongs to the ABC transporter superfamily
C2U31_02515	COG0583	DNA-binding transcription factor activity
C2U31_02520	COG2186	Transcriptional regulator
C2U31_02525	COG3395	kinase activity
C2U31_02530	COG2084	Dehydrogenase
C2U31_02535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U31_02540	COG3622	Belongs to the hyi family
C2U31_02545	COG2271	Major facilitator Superfamily
C2U31_02550	COG0235	Class ii aldolase
C2U31_02565	COG1802	Transcriptional regulator
C2U31_02570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_02600	COG0142	geranyltranstransferase activity
C2U31_02610	COG1414	Transcriptional regulator
C2U31_02615	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2U31_02620	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2U31_02625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2U31_02630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2U31_02645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U31_02650	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2U31_02665	COG5001	Diguanylate cyclase
C2U31_02670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U31_02675	COG0793	Belongs to the peptidase S41A family
C2U31_02680	COG4942	peptidase
C2U31_02685	COG0588	phosphoglycerate mutase activity
C2U31_02695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U31_02700	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C2U31_02705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2U31_02720	COG1040	competence protein
C2U31_02725	COG2226	methyltransferase
C2U31_02730	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C2U31_02735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U31_02740	COG0569	domain protein
C2U31_02745	COG2204	response regulator
C2U31_02750	COG5000	phosphorelay sensor kinase activity
C2U31_02760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U31_02760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U31_02765	COG3188	usher protein
C2U31_02770	COG3121	Chaperone
C2U31_02800	COG2197	response regulator
C2U31_02805	COG2205	protein histidine kinase activity
C2U31_02805	COG0784	Response regulator, receiver
C2U31_02810	COG5001	Diguanylate cyclase
C2U31_02810	COG3300	MHYT domain
C2U31_02820	COG1280	lysine exporter protein (LysE YggA)
C2U31_02840	COG2076	Multidrug Resistance protein
C2U31_02845	COG1733	regulation of RNA biosynthetic process
C2U31_02860	COG0546	phosphoglycolate phosphatase activity
C2U31_02880	COG0242	peptide deformylase activity
C2U31_02885	COG0758	DNA mediated transformation
C2U31_02900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_02905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_02910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2U31_02915	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_02920	COG2032	superoxide dismutase activity
C2U31_02935	COG1238	metal cluster binding
C2U31_02940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U31_02945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_02960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2U31_02965	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2U31_02970	COG4988	ABC transporter
C2U31_02980	COG1294	oxidase, subunit
C2U31_02995	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2U31_03005	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U31_03020	COG1137	ATPase activity
C2U31_03025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2U31_03035	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C2U31_03040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_03055	COG1660	Displays ATPase and GTPase activities
C2U31_03065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U31_03080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U31_03085	COG2823	Periplasmic or secreted lipoprotein
C2U31_03090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U31_03100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U31_03110	COG1309	transcriptional regulator
C2U31_03115	COG0471	metal ion transport
C2U31_03120	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2U31_03140	COG0772	Belongs to the SEDS family
C2U31_03145	COG0768	penicillin binding
C2U31_03155	COG1792	Involved in formation and maintenance of cell shape
C2U31_03160	COG1077	Cell shape determining protein MreB Mrl
C2U31_03165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2U31_03170	COG0154	amidase activity
C2U31_03175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2U31_03195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2U31_03200	COG0708	Exodeoxyribonuclease III
C2U31_03205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U31_03215	COG0583	DNA-binding transcription factor activity
C2U31_03240	COG0411	ABC transporter
C2U31_03250	COG1764	response to oxidative stress
C2U31_03255	COG1846	Transcriptional regulator
C2U31_03300	COG0730	response to heat
C2U31_03320	COG0640	Transcriptional regulator
C2U31_03350	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U31_03355	COG3189	MarR family transcriptional regulator
C2U31_03380	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2U31_03385	COG0351	phosphomethylpyrimidine kinase
C2U31_03385	COG0352	thiamine-phosphate diphosphorylase activity
C2U31_03385	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2U31_03390	COG2226	methyltransferase
C2U31_03400	COG3210	domain, Protein
C2U31_03400	COG3210	domain, Protein
C2U31_03405	COG2831	hemolysin activation secretion protein
C2U31_03410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2U31_03415	COG0513	Belongs to the DEAD box helicase family
C2U31_03425	COG0477	Major facilitator Superfamily
C2U31_03455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U31_03460	COG2308	Evidence 4 Homologs of previously reported genes of
C2U31_03470	COG1305	Transglutaminase-like
C2U31_03480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2U31_03485	COG1950	PFAM Membrane protein of
C2U31_03490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2U31_03495	COG0438	transferase activity, transferring glycosyl groups
C2U31_03520	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U31_03530	COG1301	dicarboxylic acid transport
C2U31_03540	COG1027	Aspartate ammonia-lyase
C2U31_03545	COG0596	Alpha beta hydrolase
C2U31_03555	COG0477	Major facilitator Superfamily
C2U31_03560	COG0154	amidase activity
C2U31_03600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2U31_03615	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2U31_03625	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2U31_03630	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2U31_03640	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2U31_03655	COG0735	belongs to the Fur family
C2U31_03660	COG0523	cobalamin synthesis protein
C2U31_03665	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U31_03670	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2U31_03675	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2U31_03685	COG2096	Adenosyltransferase
C2U31_03780	COG1215	transferase activity, transferring glycosyl groups
C2U31_03810	COG0110	maltose O-acetyltransferase activity
C2U31_03820	COG0529	Catalyzes the synthesis of activated sulfate
C2U31_03835	COG3848	Pyruvate phosphate dikinase
C2U31_03835	COG0574	Belongs to the PEP-utilizing enzyme family
C2U31_03840	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2U31_03850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U31_03855	COG1609	Transcriptional regulator
C2U31_03865	COG0321	lipoyl(octanoyl) transferase activity
C2U31_03870	COG2921	Belongs to the UPF0250 family
C2U31_03880	COG1686	Belongs to the peptidase S11 family
C2U31_03905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U31_03915	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2U31_03925	COG0859	PFAM glycosyl transferase family 9
C2U31_03935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2U31_03945	COG1215	transferase activity, transferring glycosyl groups
C2U31_03950	COG0562	UDP-galactopyranose mutase
C2U31_03980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U31_03990	COG2814	Major facilitator Superfamily
C2U31_03995	COG0697	spore germination
C2U31_04000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U31_04005	COG3568	Endonuclease Exonuclease Phosphatase
C2U31_04010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2U31_04035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U31_04050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_04055	COG1956	GAF domain-containing protein
C2U31_04060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_04085	COG2186	Transcriptional regulator
C2U31_04090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2U31_04135	COG2814	Major facilitator Superfamily
C2U31_04150	COG0583	DNA-binding transcription factor activity
C2U31_04160	COG1473	amidohydrolase
C2U31_04165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C2U31_04170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2U31_04175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2U31_04185	COG1965	Belongs to the frataxin family
C2U31_04195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U31_04200	COG1333	cytochrome c biogenesis protein
C2U31_04210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2U31_04240	COG0683	leucine binding
C2U31_04245	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_04260	COG4232	protein-disulfide reductase activity
C2U31_04265	COG1324	tolerance protein
C2U31_04275	COG0203	ribosomal protein L17
C2U31_04280	COG0202	RNA polymerase activity
C2U31_04285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2U31_04290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2U31_04295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2U31_04300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U31_04305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2U31_04310	COG0201	protein transport
C2U31_04315	COG0200	Binds to the 23S rRNA
C2U31_04320	COG1841	ribosomal large subunit assembly
C2U31_04325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2U31_04330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2U31_04335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2U31_04340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2U31_04345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2U31_04350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2U31_04355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2U31_04360	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2U31_04385	COG2207	Transcriptional regulator
C2U31_04400	COG0411	ABC transporter
C2U31_04405	COG0410	ABC transporter
C2U31_04430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2U31_04435	COG0255	Belongs to the universal ribosomal protein uL29 family
C2U31_04440	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2U31_04445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2U31_04450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2U31_04455	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2U31_04460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2U31_04465	COG0089	rRNA binding
C2U31_04470	COG0088	Forms part of the polypeptide exit tunnel
C2U31_04475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2U31_04480	COG0051	transcription antitermination factor activity, RNA binding
C2U31_04485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U31_04490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U31_04495	COG0049	tRNA binding
C2U31_04500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2U31_04505	COG0745	RESPONSE REGULATOR receiver
C2U31_04535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2U31_04540	COG0085	RNA polymerase activity
C2U31_04545	COG0222	ribosome binding
C2U31_04550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2U31_04555	COG0081	regulation of translation
C2U31_04560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2U31_04570	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U31_04580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U31_04605	COG1349	DNA-binding transcription factor activity
C2U31_04610	COG0252	asparaginase activity
C2U31_04615	COG1475	DNA binding
C2U31_04625	COG1192	Involved in chromosome partitioning
C2U31_04630	COG0357	Ribosomal RNA small subunit methyltransferase G
C2U31_04635	COG0445	tRNA wobble uridine modification
C2U31_04640	COG1278	Cold shock
C2U31_04645	COG3180	Ammonia monooxygenase
C2U31_04650	COG0436	Aminotransferase
C2U31_04670	COG0642	Histidine kinase
C2U31_04685	COG0038	chloride channel
C2U31_04690	COG0583	DNA-binding transcription factor activity
C2U31_04695	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C2U31_04700	COG0511	ligase activity, forming carbon-carbon bonds
C2U31_04705	COG0439	Biotin carboxylase
C2U31_04715	COG1984	allophanate hydrolase subunit 2
C2U31_04725	COG2207	Transcriptional regulator
C2U31_04740	COG1113	amino acid transport
C2U31_04760	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C2U31_04765	COG0277	FAD linked oxidase domain protein
C2U31_04770	COG2271	Major facilitator Superfamily
C2U31_04785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U31_04790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U31_04800	COG1279	arginine transmembrane transporter activity
C2U31_04820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2U31_04830	COG0601	transmembrane transport
C2U31_04835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_04840	COG0444	Belongs to the ABC transporter superfamily
C2U31_04845	COG4608	Belongs to the ABC transporter superfamily
C2U31_04850	COG1473	amidohydrolase
C2U31_04855	COG2175	clavaminate synthase activity
C2U31_04865	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2U31_04870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_04875	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C2U31_04880	COG2205	protein histidine kinase activity
C2U31_04885	COG0740	serine-type endopeptidase activity
C2U31_04905	COG0706	membrane insertase activity
C2U31_04910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2U31_04915	COG0594	ribonuclease P activity
C2U31_04920	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2U31_04925	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2U31_04930	COG0592	DNA-directed DNA polymerase activity
C2U31_04950	COG0583	DNA-binding transcription factor activity
C2U31_04965	COG1741	Belongs to the pirin family
C2U31_04975	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C2U31_05000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_05005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U31_05015	COG1414	Transcriptional regulator
C2U31_05020	COG1024	Enoyl-CoA hydratase
C2U31_05030	COG3842	ATPase activity
C2U31_05035	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U31_05050	COG1126	abc transporter atp-binding protein
C2U31_05055	COG0154	amidase activity
C2U31_05060	COG1917	Cupin 2, conserved barrel domain protein
C2U31_05085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U31_05090	COG0583	DNA-binding transcription factor activity
C2U31_05095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_05100	COG0765	amino acid transport
C2U31_05105	COG0765	amino acid transport
C2U31_05110	COG1126	abc transporter atp-binding protein
C2U31_05125	COG1254	Belongs to the acylphosphatase family
C2U31_05135	COG1304	FMN binding
C2U31_05150	COG0402	S-adenosylhomocysteine deaminase activity
C2U31_05180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2U31_05195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U31_05205	COG0436	Aminotransferase
C2U31_05210	COG1126	abc transporter atp-binding protein
C2U31_05215	COG0765	amino acid transport
C2U31_05220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_05240	COG2084	Dehydrogenase
C2U31_05245	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_05255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U31_05265	COG3781	membrane
C2U31_05270	COG1522	sequence-specific DNA binding
C2U31_05275	COG0028	Belongs to the TPP enzyme family
C2U31_05280	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_05285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_05290	COG1116	anion transmembrane transporter activity
C2U31_05300	COG0551	DNA topoisomerase type I activity
C2U31_05300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U31_05310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U31_05315	COG2922	Belongs to the Smg family
C2U31_05380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U31_05425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_05445	COG0583	DNA-binding transcription factor activity
C2U31_05450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U31_05455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_05480	COG0477	Major facilitator Superfamily
C2U31_05510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U31_05515	COG0183	Belongs to the thiolase family
C2U31_05520	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C2U31_05525	COG1960	acyl-CoA dehydrogenase activity
C2U31_05530	COG1473	amidohydrolase
C2U31_05540	COG1742	UPF0060 membrane protein
C2U31_05555	COG1280	lysine exporter protein (LysE YggA)
C2U31_05575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U31_05585	COG0018	arginyl-trna synthetase
C2U31_05600	COG2186	Transcriptional regulator
C2U31_05605	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C2U31_05615	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_05620	COG0395	ABC-type sugar transport system, permease component
C2U31_05625	COG1175	transmembrane transport
C2U31_05630	COG1653	transport
C2U31_05640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U31_05645	COG1609	Transcriptional regulator
C2U31_05655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U31_05670	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2U31_05680	COG0583	DNA-binding transcription factor activity
C2U31_05685	COG0697	spore germination
C2U31_05700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C2U31_05710	COG0513	Belongs to the DEAD box helicase family
C2U31_05715	COG5339	Protein conserved in bacteria
C2U31_05720	COG1228	amidohydrolase
C2U31_05730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_05735	COG0601	transmembrane transport
C2U31_05740	COG0747	negative chemotaxis
C2U31_05745	COG1160	GTP binding
C2U31_05760	COG0697	spore germination
C2U31_05775	COG0583	DNA-binding transcription factor activity
C2U31_05790	COG2969	positive regulation of protein catabolic process
C2U31_05795	COG0625	glutathione transferase activity
C2U31_05800	COG2857	Cytochrome c1
C2U31_05805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2U31_05810	COG0723	plastoquinol--plastocyanin reductase activity
C2U31_05815	COG1970	mechanosensitive ion channel activity
C2U31_05820	COG0235	Class ii aldolase
C2U31_05830	COG0477	Major facilitator Superfamily
C2U31_05840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U31_05845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U31_05860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U31_05865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U31_05870	COG0537	adenosine 5'-monophosphoramidase activity
C2U31_05875	COG0140	phosphoribosyl-ATP diphosphatase activity
C2U31_05880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2U31_05885	COG0107	imidazoleglycerol-phosphate synthase activity
C2U31_05890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2U31_05895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2U31_05900	COG0131	Imidazoleglycerol-phosphate dehydratase
C2U31_05905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2U31_05910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2U31_05915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2U31_05920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2U31_05930	COG0842	Transport permease protein
C2U31_05935	COG1131	(ABC) transporter
C2U31_05945	COG2853	Lipoprotein
C2U31_05950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U31_05955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U31_05960	COG1127	ABC transporter
C2U31_05975	COG0477	Major facilitator Superfamily
C2U31_05985	COG3047	cAMP biosynthetic process
C2U31_05995	COG0067	glutamate synthase
C2U31_05995	COG0069	glutamate synthase activity
C2U31_05995	COG0070	glutamate synthase
C2U31_06020	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U31_06040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U31_06070	COG1612	heme a metabolic process
C2U31_06075	COG0109	protoheme IX farnesyltransferase activity
C2U31_06080	COG1999	signal sequence binding
C2U31_06100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2U31_06105	COG2814	Major facilitator Superfamily
C2U31_06125	COG1522	sequence-specific DNA binding
C2U31_06130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U31_06165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U31_06170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U31_06175	COG4166	transmembrane transport
C2U31_06185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_06190	COG4172	Belongs to the ABC transporter superfamily
C2U31_06200	COG0667	Aldo Keto reductase
C2U31_06215	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2U31_06220	COG4608	Belongs to the ABC transporter superfamily
C2U31_06225	COG0444	Belongs to the ABC transporter superfamily
C2U31_06235	COG0601	transmembrane transport
C2U31_06240	COG0747	negative chemotaxis
C2U31_06250	COG0251	oxidation-reduction process
C2U31_06310	COG0840	transmembrane signaling receptor activity
C2U31_06315	COG5001	Diguanylate cyclase
C2U31_06335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2U31_06340	COG0583	DNA-binding transcription factor activity
C2U31_06345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U31_06355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U31_06360	COG0463	Glycosyl transferase, family 2
C2U31_06400	COG0737	Belongs to the 5'-nucleotidase family
C2U31_06430	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2U31_06450	COG0840	transmembrane signaling receptor activity
C2U31_06530	COG1464	Belongs to the NlpA lipoprotein family
C2U31_06535	COG0431	NADPH-dependent FMN reductase
C2U31_06540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U31_06545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U31_06550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_06560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U31_06565	COG2011	ABC-type metal ion transport system permease component
C2U31_06570	COG1464	Belongs to the NlpA lipoprotein family
C2U31_06575	COG1116	anion transmembrane transporter activity
C2U31_06580	COG3585	molybdate ion transport
C2U31_06605	COG3119	arylsulfatase activity
C2U31_06610	COG0583	DNA-binding transcription factor activity
C2U31_06615	COG1607	acyl-coa hydrolase
C2U31_06625	COG0477	Major facilitator Superfamily
C2U31_06630	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_06635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_06640	COG3383	formate dehydrogenase (NAD+) activity
C2U31_06640	COG0243	molybdopterin cofactor binding
C2U31_06645	COG0243	molybdopterin cofactor binding
C2U31_06645	COG3383	formate dehydrogenase (NAD+) activity
C2U31_06650	COG0437	4 iron, 4 sulfur cluster binding
C2U31_06655	COG2864	formate dehydrogenase
C2U31_06660	COG3058	Necessary for formate dehydrogenase activity
C2U31_06670	COG3276	selenocysteine insertion sequence binding
C2U31_06680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U31_06685	COG1305	Transglutaminase-like
C2U31_06720	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_06725	COG3284	Transcriptional regulator
C2U31_06730	COG0134	indole-3-glycerol-phosphate synthase activity
C2U31_06735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U31_06740	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U31_06750	COG0546	phosphoglycolate phosphatase activity
C2U31_06760	COG2967	ApaG domain
C2U31_06765	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2U31_06770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U31_06775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U31_06785	COG0037	tRNA processing
C2U31_06805	COG0583	DNA-binding transcription factor activity
C2U31_06815	COG1024	Enoyl-CoA hydratase
C2U31_06830	COG0356	it plays a direct role in the translocation of protons across the membrane
C2U31_06840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2U31_06845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2U31_06850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2U31_06855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2U31_06860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2U31_06865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2U31_06875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2U31_06880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U31_06885	COG0210	DNA helicase
C2U31_06900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U31_06905	COG2171	N-acyltransferase activity
C2U31_06910	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2U31_06920	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U31_06930	COG4608	Belongs to the ABC transporter superfamily
C2U31_06935	COG0444	Belongs to the ABC transporter superfamily
C2U31_06940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_06945	COG0601	transmembrane transport
C2U31_06950	COG0747	negative chemotaxis
C2U31_06955	COG2988	succinylglutamate desuccinylase activity
C2U31_06965	COG0583	DNA-binding transcription factor activity
C2U31_06970	COG0747	negative chemotaxis
C2U31_06980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U31_06985	COG1024	Enoyl-CoA hydratase
C2U31_07000	COG1309	transcriptional regulator
C2U31_07015	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_07055	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2U31_07065	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_07075	COG1129	ABC transporter
C2U31_07090	COG1802	Transcriptional regulator
C2U31_07110	COG2918	glutathione biosynthetic process
C2U31_07125	COG2197	response regulator
C2U31_07135	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2U31_07140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U31_07150	COG2721	sulfolactate sulfo-lyase activity
C2U31_07155	COG2721	sulfolactate sulfo-lyase activity
C2U31_07160	COG2188	Transcriptional regulator
C2U31_07165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U31_07170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U31_07170	COG2813	Specifically methylates the guanine in position
C2U31_07175	COG2223	nitrite transmembrane transporter activity
C2U31_07185	COG2860	membrane
C2U31_07190	COG1802	Transcriptional regulator
C2U31_07195	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C2U31_07200	COG1984	allophanate hydrolase subunit 2
C2U31_07205	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2U31_07220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U31_07235	COG2132	Multicopper oxidase
C2U31_07240	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C2U31_07245	COG0642	Histidine kinase
C2U31_07260	COG0745	RESPONSE REGULATOR receiver
C2U31_07265	COG2226	methyltransferase
C2U31_07280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U31_07290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2U31_07305	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U31_07310	COG0351	phosphomethylpyrimidine kinase
C2U31_07315	COG2022	thiamine diphosphate biosynthetic process
C2U31_07320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U31_07325	COG4771	TonB-dependent receptor
C2U31_07340	COG2186	Transcriptional regulator
C2U31_07350	COG2177	Part of the ABC transporter FtsEX involved in
C2U31_07355	COG2884	Cell division ATP-binding protein ftsE
C2U31_07360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_07365	COG4597	amino acid ABC transporter
C2U31_07370	COG0765	amino acid transport
C2U31_07375	COG1126	abc transporter atp-binding protein
C2U31_07385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_07390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_07410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U31_07415	COG2081	HI0933 family
C2U31_07425	COG0077	Prephenate dehydratase
C2U31_07425	COG1605	Chorismate mutase
C2U31_07455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2U31_07460	COG0477	Major facilitator Superfamily
C2U31_07470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2U31_07475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2U31_07480	COG4566	intracellular signal transduction
C2U31_07495	COG0237	dephospho-CoA kinase activity
C2U31_07500	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C2U31_07510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_07520	COG1538	Outer membrane efflux protein
C2U31_07525	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_07530	COG0583	DNA-binding transcription factor activity
C2U31_07540	COG0154	amidase activity
C2U31_07550	COG0583	DNA-binding transcription factor activity
C2U31_07570	COG0410	ABC transporter
C2U31_07600	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2U31_07620	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_07635	COG0410	ABC transporter
C2U31_07655	COG3706	GGDEF domain
C2U31_07660	COG2199	diguanylate cyclase activity
C2U31_07660	COG2200	EAL domain
C2U31_07660	COG2202	Pas domain
C2U31_07670	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_07675	COG1024	Enoyl-CoA hydratase
C2U31_07715	COG4638	Rieske (2fe-2S)
C2U31_07720	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U31_07725	COG1335	isochorismatase
C2U31_07730	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_07740	COG0741	lytic transglycosylase activity
C2U31_07745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U31_07765	COG1678	Uncharacterized ACR, COG1678
C2U31_07770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2U31_07795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U31_07805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_07815	COG0765	amino acid transport
C2U31_07820	COG1126	abc transporter atp-binding protein
C2U31_07825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U31_07835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U31_07840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U31_07850	COG3842	ATPase activity
C2U31_07855	COG1175	transmembrane transport
C2U31_07875	COG2972	Histidine kinase
C2U31_07875	COG2205	protein histidine kinase activity
C2U31_07885	COG0557	exoribonuclease II activity
C2U31_07890	COG3150	esterase
C2U31_07895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U31_07900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U31_07905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2U31_07910	COG0511	ligase activity, forming carbon-carbon bonds
C2U31_07915	COG0439	Biotin carboxylase
C2U31_07920	COG2264	protein methyltransferase activity
C2U31_07955	COG1696	Membrane protein involved in D-alanine export
C2U31_08000	COG2814	Major facilitator Superfamily
C2U31_08010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U31_08015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U31_08015	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U31_08015	COG1042	CoA-binding domain protein
C2U31_08025	COG3028	Belongs to the UPF0307 family
C2U31_08030	COG0312	modulator of DNA gyrase
C2U31_08035	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C2U31_08045	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_08065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2U31_08070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2U31_08075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2U31_08085	COG0316	Belongs to the HesB IscA family
C2U31_08090	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2U31_08100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U31_08105	COG1881	PFAM PEBP family protein
C2U31_08110	COG1280	lysine exporter protein (LysE YggA)
C2U31_08115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U31_08120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2U31_08130	COG1335	isochorismatase
C2U31_08135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U31_08135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U31_08150	COG2766	serine protein kinase
C2U31_08155	COG2718	Belongs to the UPF0229 family
C2U31_08160	COG2719	SpoVR family
C2U31_08195	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_08200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C2U31_08205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2U31_08225	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_08260	COG2070	2-Nitropropane dioxygenase
C2U31_08280	COG0840	transmembrane signaling receptor activity
C2U31_08305	COG0741	lytic transglycosylase activity
C2U31_08305	COG1388	LysM domain
C2U31_08315	COG2226	methyltransferase
C2U31_08320	COG0328	RNA-DNA hybrid ribonuclease activity
C2U31_08330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_08335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U31_08350	COG1671	Belongs to the UPF0178 family
C2U31_08365	COG0786	glutamate:sodium symporter activity
C2U31_08375	COG0463	Glycosyl transferase, family 2
C2U31_08380	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U31_08395	COG0583	DNA-binding transcription factor activity
C2U31_08410	COG0583	DNA-binding transcription factor activity
C2U31_08420	COG1346	cytolysis
C2U31_08430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_08445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U31_08455	COG1522	sequence-specific DNA binding
C2U31_08460	COG2267	carboxylic ester hydrolase activity
C2U31_08470	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C2U31_08475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U31_08490	COG0823	Involved in the tonB-independent uptake of proteins
C2U31_08500	COG0848	biopolymer transport protein
C2U31_08505	COG0811	peptide transport
C2U31_08510	COG0824	Thioesterase
C2U31_08515	COG0442	prolyl-tRNA aminoacylation
C2U31_08535	COG3842	ATPase activity
C2U31_08540	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U31_08555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U31_08560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U31_08565	COG0583	DNA-binding transcription factor activity
C2U31_08585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U31_08595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U31_08600	COG2084	Dehydrogenase
C2U31_08645	COG0129	dihydroxy-acid dehydratase activity
C2U31_08650	COG4654	Cytochrome c, class I
C2U31_08655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U31_08665	COG1522	sequence-specific DNA binding
C2U31_08705	COG1473	amidohydrolase
C2U31_08710	COG0418	dihydroorotase activity
C2U31_08725	COG2001	Belongs to the MraZ family
C2U31_08730	COG0275	rRNA processing
C2U31_08735	COG3116	cell division
C2U31_08745	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U31_08750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U31_08755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2U31_08765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2U31_08770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U31_08775	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U31_08780	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2U31_08795	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2U31_08805	COG0739	heme binding
C2U31_08810	COG0653	protein targeting
C2U31_08825	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_08830	COG0028	Belongs to the TPP enzyme family
C2U31_08840	COG0300	oxidoreductase activity
C2U31_08845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_08850	COG1522	sequence-specific DNA binding
C2U31_08865	COG2239	Acts as a magnesium transporter
C2U31_08870	COG1607	acyl-coa hydrolase
C2U31_08875	COG2855	membrane
C2U31_08885	COG1473	amidohydrolase
C2U31_08890	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_08900	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C2U31_08900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_08905	COG1501	Belongs to the glycosyl hydrolase 31 family
C2U31_08910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U31_08915	COG2011	ABC-type metal ion transport system permease component
C2U31_08940	COG0735	belongs to the Fur family
C2U31_08960	COG2818	Glycosylase
C2U31_08965	COG1368	sulfuric ester hydrolase activity
C2U31_08970	COG2982	Protein involved in outer membrane biogenesis
C2U31_08975	COG3706	GGDEF domain
C2U31_08980	COG1309	transcriptional regulator
C2U31_08985	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_09005	COG0473	3-isopropylmalate dehydrogenase activity
C2U31_09020	COG2154	pterin-4-alpha-carbinolamine dehydratase
C2U31_09030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2U31_09040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2U31_09045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U31_09050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2U31_09055	COG1929	Belongs to the glycerate kinase type-1 family
C2U31_09060	COG0469	pyruvate kinase activity
C2U31_09065	COG0700	Nucleoside recognition
C2U31_09070	COG1960	acyl-CoA dehydrogenase activity
C2U31_09075	COG0242	peptide deformylase activity
C2U31_09095	COG0204	Acyl-transferase
C2U31_09100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U31_09105	COG0751	glycine-tRNA ligase activity
C2U31_09110	COG0752	glycyl-tRNA synthetase alpha subunit
C2U31_09115	COG1024	Enoyl-CoA hydratase
C2U31_09130	COG2030	dehydratase
C2U31_09135	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_09140	COG0583	DNA-binding transcription factor activity
C2U31_09155	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_09160	COG0183	Belongs to the thiolase family
C2U31_09170	COG1960	acyl-CoA dehydrogenase activity
C2U31_09180	COG1024	Enoyl-CoA hydratase
C2U31_09190	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C2U31_09205	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2U31_09215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U31_09225	COG0617	tRNA 3'-terminal CCA addition
C2U31_09240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2U31_09245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2U31_09250	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U31_09255	COG0586	Pfam SNARE associated Golgi protein
C2U31_09260	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2U31_09265	COG0802	atpase or kinase
C2U31_09270	COG0114	fumarate hydratase activity
C2U31_09280	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_09295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_09305	COG1960	acyl-CoA dehydrogenase activity
C2U31_09310	COG0583	DNA-binding transcription factor activity
C2U31_09320	COG0579	oxidoreductase
C2U31_09325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U31_09330	COG0259	pyridoxamine-phosphate oxidase activity
C2U31_09345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_09350	COG1136	(ABC) transporter
C2U31_09350	COG0577	efflux transmembrane transporter activity
C2U31_09355	COG1538	Outer membrane efflux protein
C2U31_09360	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U31_09405	COG0640	Transcriptional regulator
C2U31_09425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U31_09450	COG2197	response regulator
C2U31_09485	COG0653	protein targeting
C2U31_09490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_09505	COG0583	DNA-binding transcription factor activity
C2U31_09510	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_09520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U31_09530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2U31_09535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2U31_09555	COG0583	DNA-binding transcription factor activity
C2U31_09560	COG0463	Glycosyl transferase, family 2
C2U31_09560	COG1216	Glycosyl transferase, family 2
C2U31_09565	COG0410	ABC transporter
C2U31_09570	COG0411	ABC transporter
C2U31_09590	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C2U31_09610	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U31_09615	COG4638	Rieske (2fe-2S)
C2U31_09640	COG0747	negative chemotaxis
C2U31_09650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_09655	COG0444	Belongs to the ABC transporter superfamily
C2U31_09660	COG4608	Belongs to the ABC transporter superfamily
C2U31_09680	COG0488	(ABC) transporter
C2U31_09700	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2U31_09705	COG2894	cell division
C2U31_09710	COG0850	regulation of cytokinetic process
C2U31_09715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U31_09720	COG1271	oxidase subunit
C2U31_09725	COG1294	oxidase, subunit
C2U31_09730	COG0514	ATP-dependent DNA helicase (RecQ)
C2U31_09740	COG0745	RESPONSE REGULATOR receiver
C2U31_09750	COG2255	four-way junction helicase activity
C2U31_09765	COG0632	four-way junction helicase activity
C2U31_09770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2U31_09790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U31_09800	COG0006	proline dipeptidase activity
C2U31_09815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2U31_09835	COG4783	chaperone-mediated protein folding
C2U31_09870	COG0513	Belongs to the DEAD box helicase family
C2U31_09890	COG1414	Transcriptional regulator
C2U31_09905	COG0167	dihydroorotate dehydrogenase activity
C2U31_09910	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C2U31_09915	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2U31_09925	COG0583	DNA-binding transcription factor activity
C2U31_09960	COG3128	pkhd-type hydroxylase
C2U31_09965	COG4774	siderophore transport
C2U31_09975	COG2721	sulfolactate sulfo-lyase activity
C2U31_09980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_09990	COG4597	amino acid ABC transporter
C2U31_09995	COG0765	amino acid transport
C2U31_10000	COG1802	Transcriptional regulator
C2U31_10015	COG1192	Involved in chromosome partitioning
C2U31_10050	COG0629	single-stranded DNA binding
C2U31_10060	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2U31_10110	COG0740	serine-type endopeptidase activity
C2U31_10200	COG1280	lysine exporter protein (LysE YggA)
C2U31_10295	COG2003	Belongs to the UPF0758 family
C2U31_10300	COG0477	Major facilitator Superfamily
C2U31_10380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2U31_10385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2U31_10390	COG3135	benzoate transporter
C2U31_10395	COG2271	Major facilitator Superfamily
C2U31_10420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U31_10425	COG0183	Belongs to the thiolase family
C2U31_10430	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U31_10440	COG2814	Major facilitator Superfamily
C2U31_10450	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_10470	COG3485	protocatechuate 3,4-dioxygenase
C2U31_10490	COG0583	DNA-binding transcription factor activity
C2U31_10495	COG2814	Major facilitator Superfamily
C2U31_10500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U31_10510	COG0702	epimerase
C2U31_10515	COG1733	regulation of RNA biosynthetic process
C2U31_10520	COG2814	Major facilitator Superfamily
C2U31_10525	COG2084	Dehydrogenase
C2U31_10530	COG1309	transcriptional regulator
C2U31_10560	COG3479	Phenolic acid decarboxylase
C2U31_10565	COG0583	DNA-binding transcription factor activity
C2U31_10570	COG0604	alcohol dehydrogenase
C2U31_10580	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2U31_10585	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_10595	COG2814	Major facilitator Superfamily
C2U31_10605	COG0583	DNA-binding transcription factor activity
C2U31_10620	COG0582	viral genome integration into host DNA
C2U31_10630	COG3038	cytochrome b561
C2U31_10645	COG1459	type II secretion system
C2U31_10675	COG1450	Type ii and iii secretion system protein
C2U31_10680	COG2165	general secretion pathway protein
C2U31_10695	COG0745	RESPONSE REGULATOR receiver
C2U31_10700	COG5002	protein histidine kinase activity
C2U31_10710	COG2814	Major facilitator Superfamily
C2U31_10735	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_10745	COG0247	lactate metabolic process
C2U31_10780	COG1192	Involved in chromosome partitioning
C2U31_10840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U31_11090	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2U31_11095	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U31_11100	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U31_11105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U31_11125	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_11135	COG0842	Transport permease protein
C2U31_11140	COG1129	ABC transporter
C2U31_11140	COG0842	Transport permease protein
C2U31_11165	COG0583	DNA-binding transcription factor activity
C2U31_11180	COG0582	viral genome integration into host DNA
C2U31_11195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2U31_11200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U31_11205	COG0735	belongs to the Fur family
C2U31_11210	COG0497	DNA recombination
C2U31_11215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2U31_11220	COG1420	regulation of RNA biosynthetic process
C2U31_11225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2U31_11235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2U31_11245	COG0443	Heat shock 70 kDa protein
C2U31_11250	COG0484	heat shock protein binding
C2U31_11260	COG0612	Peptidase, M16
C2U31_11285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U31_11320	COG0840	transmembrane signaling receptor activity
C2U31_11325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_11340	COG0745	RESPONSE REGULATOR receiver
C2U31_11345	COG2205	protein histidine kinase activity
C2U31_11350	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C2U31_11355	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C2U31_11375	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U31_11385	COG1193	negative regulation of DNA recombination
C2U31_11390	COG0492	ferredoxin-NADP+ reductase activity
C2U31_11395	COG1674	ftsk spoiiie
C2U31_11400	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2U31_11405	COG0251	oxidation-reduction process
C2U31_11410	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2U31_11415	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U31_11415	COG0517	IMP dehydrogenase activity
C2U31_11435	COG0601	transmembrane transport
C2U31_11450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U31_11470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U31_11490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2U31_11530	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2U31_11535	COG0840	transmembrane signaling receptor activity
C2U31_11540	COG2205	protein histidine kinase activity
C2U31_11570	COG2274	protein secretion by the type I secretion system
C2U31_11585	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_11590	COG3022	response to hydroperoxide
C2U31_11595	COG1289	transmembrane transporter activity
C2U31_11600	COG0028	Belongs to the TPP enzyme family
C2U31_11605	COG0440	acetolactate synthase activity
C2U31_11610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2U31_11615	COG1183	phosphatidylcholine synthase activity
C2U31_11625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2U31_11630	COG1185	polyribonucleotide nucleotidyltransferase activity
C2U31_11645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_11675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U31_11690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U31_11705	COG3121	Chaperone
C2U31_11725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U31_11735	COG2197	response regulator
C2U31_11740	COG4251	negative regulation of phosphorylation
C2U31_11740	COG5001	Diguanylate cyclase
C2U31_11740	COG3706	GGDEF domain
C2U31_11740	COG2203	Gaf domain
C2U31_11755	COG0583	DNA-binding transcription factor activity
C2U31_11760	COG0583	DNA-binding transcription factor activity
C2U31_11765	COG0745	RESPONSE REGULATOR receiver
C2U31_11790	COG0149	triose-phosphate isomerase activity
C2U31_11795	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U31_11840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U31_11880	COG0662	Cupin 2, conserved barrel domain protein
C2U31_11890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U31_11890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U31_11900	COG0583	DNA-binding transcription factor activity
C2U31_11905	COG2203	Gaf domain
C2U31_11905	COG2199	diguanylate cyclase activity
C2U31_11955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U31_11955	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C2U31_11980	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C2U31_11985	COG0789	Transcriptional regulator
C2U31_11990	COG0583	DNA-binding transcription factor activity
C2U31_12000	COG2271	Major facilitator Superfamily
C2U31_12030	COG3328	transposase activity
C2U31_12045	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_12065	COG2957	Belongs to the agmatine deiminase family
C2U31_12095	COG0477	Major facilitator Superfamily
C2U31_12105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2U31_12115	COG0642	Histidine kinase
C2U31_12125	COG2851	Citrate transporter
C2U31_12130	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_12170	COG3604	Transcriptional regulator
C2U31_12175	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C2U31_12185	COG3246	L-lysine catabolic process to acetate
C2U31_12190	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C2U31_12195	COG2814	Major facilitator Superfamily
C2U31_12210	COG4804	nuclease activity
C2U31_12225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_12240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U31_12250	COG3135	benzoate transporter
C2U31_12255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U31_12260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U31_12270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_12275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_12295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_12300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_12305	COG1309	transcriptional regulator
C2U31_12310	COG0583	DNA-binding transcription factor activity
C2U31_12320	COG0405	Gamma-glutamyltransferase
C2U31_12330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U31_12355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_12360	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U31_12365	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U31_12370	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U31_12375	COG0649	NAD binding
C2U31_12380	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C2U31_12390	COG1034	ATP synthesis coupled electron transport
C2U31_12395	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2U31_12400	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U31_12410	COG0713	ATP synthesis coupled electron transport
C2U31_12425	COG1007	ATP synthesis coupled electron transport
C2U31_12435	COG4774	siderophore transport
C2U31_12440	COG0560	Phosphoserine phosphatase
C2U31_12445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U31_12450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2U31_12455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2U31_12465	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U31_12470	COG0450	alkyl hydroperoxide reductase
C2U31_12475	COG2205	protein histidine kinase activity
C2U31_12480	COG0745	RESPONSE REGULATOR receiver
C2U31_12485	COG1214	PFAM Peptidase M22, glycoprotease
C2U31_12490	COG1573	uracil-dna glycosylase
C2U31_12495	COG0477	Major facilitator Superfamily
C2U31_12500	COG1196	nuclear chromosome segregation
C2U31_12510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2U31_12515	COG1414	Transcriptional regulator
C2U31_12535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U31_12540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U31_12550	COG2917	probably involved in intracellular septation
C2U31_12555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U31_12560	COG1122	ATPase activity
C2U31_12565	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2U31_12570	COG1268	BioY protein
C2U31_12590	COG0410	ABC transporter
C2U31_12605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U31_12615	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_12630	COG0411	ABC transporter
C2U31_12635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2U31_12640	COG2878	Part of a membrane complex involved in electron transport
C2U31_12665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2U31_12675	COG0251	oxidation-reduction process
C2U31_12685	COG3228	Belongs to the MtfA family
C2U31_12690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U31_12700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U31_12705	COG0133	tryptophan synthase activity
C2U31_12710	COG0159	tryptophan synthase activity
C2U31_12715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2U31_12725	COG4804	nuclease activity
C2U31_12740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2U31_12750	COG3077	Addiction module antitoxin, RelB DinJ family
C2U31_12775	COG5489	Protein of unknown function (DUF736)
C2U31_12810	COG1192	Involved in chromosome partitioning
C2U31_12835	COG3316	Transposase and inactivated derivatives
C2U31_12885	COG0583	DNA-binding transcription factor activity
C2U31_12905	COG4962	Type ii secretion system protein e
C2U31_12910	COG3838	Conjugal transfer protein Trbc
C2U31_12920	COG3451	type IV secretory pathway VirB4
C2U31_12960	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2U31_12970	COG1530	ribonuclease E activity
C2U31_12980	COG0546	phosphoglycolate phosphatase activity
C2U31_12985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U31_12990	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C2U31_12995	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U31_13005	COG0424	maF-like protein
C2U31_13010	COG1399	metal-binding, possibly nucleic acid-binding protein
C2U31_13015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2U31_13020	COG0416	fatty acid biosynthetic process
C2U31_13025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U31_13030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2U31_13040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U31_13045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U31_13070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U31_13075	COG0481	GTPase activity
C2U31_13080	COG0681	Belongs to the peptidase S26 family
C2U31_13085	COG0571	ribonuclease III activity
C2U31_13090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2U31_13095	COG1381	Involved in DNA repair and RecF pathway recombination
C2U31_13100	COG0583	DNA-binding transcription factor activity
C2U31_13135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U31_13160	COG0583	DNA-binding transcription factor activity
C2U31_13170	COG0791	NLP P60 protein
C2U31_13180	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C2U31_13195	COG0697	spore germination
C2U31_13200	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C2U31_13250	COG2153	protein acetylation
C2U31_13260	COG1446	asparaginase
C2U31_13265	COG4172	Belongs to the ABC transporter superfamily
C2U31_13270	COG0747	negative chemotaxis
C2U31_13305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_13315	COG0504	CTP synthase activity
C2U31_13325	COG0148	phosphopyruvate hydratase activity
C2U31_13340	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2U31_13350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U31_13405	COG0039	L-malate dehydrogenase activity
C2U31_13410	COG2188	Transcriptional regulator
C2U31_13415	COG2009	succinate dehydrogenase
C2U31_13420	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U31_13425	COG1053	succinate dehydrogenase
C2U31_13430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U31_13435	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U31_13440	COG0372	Belongs to the citrate synthase family
C2U31_13460	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_13470	COG1129	ABC transporter
C2U31_13485	COG0642	Histidine kinase
C2U31_13490	COG0745	RESPONSE REGULATOR receiver
C2U31_13510	COG0280	phosphate acetyltransferase
C2U31_13510	COG0281	malic enzyme
C2U31_13520	COG1297	OPT oligopeptide transporter protein
C2U31_13530	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C2U31_13535	COG1522	sequence-specific DNA binding
C2U31_13540	COG0567	Dehydrogenase, E1 component
C2U31_13545	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U31_13550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U31_13555	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U31_13580	COG0372	Belongs to the citrate synthase family
C2U31_13590	COG0180	Tryptophanyl-tRNA synthetase
C2U31_13605	COG2183	response to ionizing radiation
C2U31_13610	COG1199	ATP-dependent helicase activity
C2U31_13620	COG0564	pseudouridine synthase activity
C2U31_13630	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U31_13635	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_13640	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
C2U31_13680	COG3237	CsbD-like
C2U31_13695	COG1132	(ABC) transporter
C2U31_13710	COG2833	Protein of unknown function (DUF455)
C2U31_13715	COG2951	lytic endotransglycosylase activity
C2U31_13730	COG1960	acyl-CoA dehydrogenase activity
C2U31_13750	COG1696	Membrane protein involved in D-alanine export
C2U31_13770	COG1215	transferase activity, transferring glycosyl groups
C2U31_13780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2U31_13790	COG0582	viral genome integration into host DNA
C2U31_13915	COG0305	Participates in initiation and elongation during chromosome replication
C2U31_14035	COG4386	tail sheath protein
C2U31_14075	COG3299	homolog of phage Mu protein gp47
C2U31_14150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U31_14165	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2U31_14180	COG0287	Prephenate dehydrogenase
C2U31_14185	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2U31_14190	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2U31_14210	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2U31_14215	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2U31_14220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U31_14225	COG1596	polysaccharide export
C2U31_14225	COG1555	photosystem II stabilization
C2U31_14240	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2U31_14255	COG0450	alkyl hydroperoxide reductase
C2U31_14270	COG4208	sulfate ABC transporter
C2U31_14280	COG0175	sulfate reduction
C2U31_14290	COG2895	sulfate adenylyltransferase (ATP) activity
C2U31_14310	COG0335	large ribosomal subunit rRNA binding
C2U31_14315	COG0494	nUDIX hydrolase
C2U31_14320	COG1162	GTPase activity
C2U31_14325	COG0501	Belongs to the peptidase M48B family
C2U31_14330	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2U31_14335	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U31_14340	COG3327	negative regulation of DNA-templated transcription, initiation
C2U31_14345	COG3396	Phenylacetate-CoA oxygenase
C2U31_14350	COG3460	Phenylacetate-CoA oxygenase
C2U31_14355	COG3396	Phenylacetate-CoA oxygenase
C2U31_14360	COG2151	metal-sulfur cluster biosynthetic enzyme
C2U31_14365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U31_14370	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_14375	COG1024	Enoyl-CoA hydratase
C2U31_14380	COG2050	protein possibly involved in aromatic compounds catabolism
C2U31_14400	COG0254	rRNA binding
C2U31_14405	COG3483	tryptophan 2,3-dioxygenase activity
C2U31_14410	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C2U31_14415	COG2003	Belongs to the UPF0758 family
C2U31_14430	COG0625	glutathione transferase activity
C2U31_14435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U31_14440	COG0642	Histidine kinase
C2U31_14445	COG0745	RESPONSE REGULATOR receiver
C2U31_14460	COG0523	cobalamin synthesis protein
C2U31_14465	COG0583	DNA-binding transcription factor activity
C2U31_14475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2U31_14480	COG1187	pseudouridine synthase activity
C2U31_14485	COG0779	Required for maturation of 30S ribosomal subunits
C2U31_14490	COG0195	Participates in both transcription termination and antitermination
C2U31_14490	COG2251	uridine kinase activity
C2U31_14495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2U31_14500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2U31_14505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2U31_14520	COG0583	DNA-binding transcription factor activity
C2U31_14530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U31_14530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U31_14535	COG0428	transporter
C2U31_14540	COG0412	Dienelactone hydrolase
C2U31_14545	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2U31_14550	COG1760	l-serine dehydratase
C2U31_14560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U31_14565	COG2706	6-phosphogluconolactonase activity
C2U31_14570	COG4214	carbohydrate transport
C2U31_14575	COG1129	ABC transporter
C2U31_14580	COG4213	ABC transporter substrate-binding protein
C2U31_14590	COG0501	Belongs to the peptidase M48B family
C2U31_14615	COG3842	ATPase activity
C2U31_14625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U31_14630	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U31_14650	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_14660	COG1722	exodeoxyribonuclease VII activity
C2U31_14665	COG0142	geranyltranstransferase activity
C2U31_14670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2U31_14675	COG1469	GTP cyclohydrolase I activity
C2U31_14680	COG3739	integral membrane protein
C2U31_14685	COG0360	Binds together with S18 to 16S ribosomal RNA
C2U31_14690	COG2965	DNA replication, synthesis of RNA primer
C2U31_14695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2U31_14700	COG0359	binds to the 23S rRNA
C2U31_14710	COG0305	Participates in initiation and elongation during chromosome replication
C2U31_14720	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U31_14755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_14810	COG0540	Belongs to the ATCase OTCase family
C2U31_14830	COG0477	Major facilitator Superfamily
C2U31_14835	COG0642	Histidine kinase
C2U31_14845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2U31_14850	COG2137	regulation of response to DNA damage stimulus
C2U31_14855	COG0583	DNA-binding transcription factor activity
C2U31_14860	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2U31_14865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U31_14875	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U31_14880	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2U31_14885	COG0861	Integral membrane protein TerC family
C2U31_14890	COG0861	Integral membrane protein TerC family
C2U31_14895	COG0181	hydroxymethylbilane synthase activity
C2U31_14915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2U31_14925	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_14940	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_14945	COG0411	ABC transporter
C2U31_14955	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_14975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2U31_14980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U31_14990	COG0436	Aminotransferase
C2U31_15010	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2U31_15015	COG0308	aminopeptidase N
C2U31_15030	COG0312	modulator of DNA gyrase
C2U31_15035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U31_15040	COG0277	FAD linked oxidase domain protein
C2U31_15045	COG0277	FAD linked oxidase domain protein
C2U31_15050	COG0277	FAD linked oxidase domain protein
C2U31_15055	COG0247	lactate metabolic process
C2U31_15060	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2U31_15065	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2U31_15070	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2U31_15085	COG0583	DNA-binding transcription factor activity
C2U31_15090	COG0482	sulfurtransferase activity
C2U31_15095	COG0730	response to heat
C2U31_15100	COG0625	glutathione transferase activity
C2U31_15110	COG3909	cytochrome
C2U31_15285	COG0697	spore germination
C2U31_15325	COG0069	glutamate synthase activity
C2U31_15330	COG2391	methyltransferase activity
C2U31_15340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2U31_15350	COG0697	spore germination
C2U31_15355	COG2153	protein acetylation
C2U31_15360	COG0583	DNA-binding transcription factor activity
C2U31_15365	COG0477	Major facilitator Superfamily
C2U31_15385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U31_15395	COG1760	l-serine dehydratase
C2U31_15410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2U31_15410	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U31_15445	COG0557	exoribonuclease II activity
C2U31_15450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U31_15455	COG0626	cystathionine gamma-synthase activity
C2U31_15460	COG3128	pkhd-type hydroxylase
C2U31_15465	COG0776	regulation of translation
C2U31_15490	COG0745	RESPONSE REGULATOR receiver
C2U31_15495	COG0642	Histidine kinase
C2U31_15500	COG3158	transport of potassium into the cell
C2U31_15505	COG0137	argininosuccinate synthase activity
C2U31_15535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2U31_15540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U31_15565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2U31_15570	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U31_15580	COG2376	Dihydroxyacetone kinase
C2U31_15595	COG3842	ATPase activity
C2U31_15600	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U31_15605	COG1177	transmembrane transport
C2U31_15610	COG1393	Belongs to the ArsC family
C2U31_15615	COG2094	Belongs to the DNA glycosylase MPG family
C2U31_15625	COG1322	Protein conserved in bacteria
C2U31_15635	COG1960	acyl-CoA dehydrogenase activity
C2U31_15640	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U31_15655	COG0704	Plays a role in the regulation of phosphate uptake
C2U31_15720	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C2U31_15725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U31_15725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2U31_15730	COG1643	Atp-dependent helicase
C2U31_15740	COG1116	anion transmembrane transporter activity
C2U31_15755	COG0438	transferase activity, transferring glycosyl groups
C2U31_15760	COG0726	polysaccharide deacetylase
C2U31_15765	COG0463	Glycosyl transferase, family 2
C2U31_15775	COG0726	polysaccharide deacetylase
C2U31_15805	COG1132	(ABC) transporter
C2U31_15810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U31_15810	COG0475	glutathione-regulated potassium exporter activity
C2U31_15825	COG3706	GGDEF domain
C2U31_15825	COG2203	Gaf domain
C2U31_15825	COG4251	negative regulation of phosphorylation
C2U31_15825	COG5001	Diguanylate cyclase
C2U31_15845	COG1530	ribonuclease E activity
C2U31_15890	COG0583	DNA-binding transcription factor activity
C2U31_15905	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_15915	COG0477	Major facilitator Superfamily
C2U31_15925	COG0154	amidase activity
C2U31_15945	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2U31_15960	COG0495	leucyl-tRNA aminoacylation
C2U31_15965	COG2814	Major facilitator Superfamily
C2U31_15980	COG1686	Belongs to the peptidase S11 family
C2U31_16015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2U31_16020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2U31_16025	COG2814	Major facilitator Superfamily
C2U31_16045	COG4176	ABC-type proline glycine betaine transport system permease component
C2U31_16050	COG4175	Glycine betaine
C2U31_16050	COG3448	diguanylate cyclase activity
C2U31_16060	COG0183	Belongs to the thiolase family
C2U31_16070	COG1802	Transcriptional regulator
C2U31_16080	COG1024	Enoyl-CoA hydratase
C2U31_16085	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_16095	COG1595	DNA-templated transcription, initiation
C2U31_16100	COG3712	iron ion homeostasis
C2U31_16120	COG4120	Belongs to the binding-protein-dependent transport system permease family
C2U31_16125	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C2U31_16135	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2U31_16155	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C2U31_16160	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2U31_16165	COG4149	molybdate abc transporter
C2U31_16170	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U31_16195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_16200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_16210	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U31_16215	COG0736	holo-[acyl-carrier-protein] synthase activity
C2U31_16220	COG1472	Belongs to the glycosyl hydrolase 3 family
C2U31_16225	COG0322	excinuclease ABC activity
C2U31_16230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U31_16240	COG1858	cytochrome C peroxidase
C2U31_16245	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U31_16245	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U31_16250	COG2224	Isocitrate lyase
C2U31_16255	COG1802	Transcriptional regulator
C2U31_16260	COG1879	ABC-type sugar transport system periplasmic component
C2U31_16265	COG1129	ABC transporter
C2U31_16270	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U31_16275	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_16280	COG3246	L-lysine catabolic process to acetate
C2U31_16285	COG3386	PFAM SMP-30 Gluconolaconase
C2U31_16290	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2U31_16290	COG4106	trans-aconitate 2-methyltransferase activity
C2U31_16300	COG0156	8-amino-7-oxononanoate synthase activity
C2U31_16305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2U31_16320	COG3278	Belongs to the heme-copper respiratory oxidase family
C2U31_16340	COG0348	domain, Protein
C2U31_16370	COG4948	Mandelate Racemase Muconate Lactonizing
C2U31_16380	COG1131	(ABC) transporter
C2U31_16385	COG0842	Transport permease protein
C2U31_16415	COG1272	protein, Hemolysin III
C2U31_16445	COG2169	Transcriptional regulator
C2U31_16475	COG1024	Enoyl-CoA hydratase
C2U31_16480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_16485	COG0154	amidase activity
C2U31_16490	COG2186	Transcriptional regulator
C2U31_16510	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_16525	COG3708	Transcriptional regulator
C2U31_16525	COG2207	Transcriptional regulator
C2U31_16530	COG2814	Major facilitator Superfamily
C2U31_16540	COG1464	Belongs to the NlpA lipoprotein family
C2U31_16545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U31_16550	COG2011	ABC-type metal ion transport system permease component
C2U31_16595	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_16620	COG0443	Heat shock 70 kDa protein
C2U31_16625	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
C2U31_16635	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U31_16665	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_16670	COG1473	amidohydrolase
C2U31_16680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U31_16700	COG2951	lytic endotransglycosylase activity
C2U31_16705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U31_16720	COG0456	acetyltransferase
C2U31_16735	COG0601	transmembrane transport
C2U31_16740	COG4166	transmembrane transport
C2U31_16745	COG4172	Belongs to the ABC transporter superfamily
C2U31_16755	COG0488	(ABC) transporter
C2U31_16765	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U31_16795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U31_16800	COG1595	DNA-templated transcription, initiation
C2U31_16815	COG3530	Putative quorum-sensing-regulated virulence factor
C2U31_16820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2U31_16825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2U31_16830	COG0189	ligase activity
C2U31_16840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U31_16845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U31_16850	COG0004	ammonium transporteR
C2U31_16855	COG0347	Belongs to the P(II) protein family
C2U31_16865	COG2960	long-chain fatty acid transporting porin activity
C2U31_16875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2U31_16880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2U31_16885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2U31_16890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U31_16890	COG0072	phenylalanine-tRNA ligase activity
C2U31_16895	COG0776	regulation of translation
C2U31_16915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U31_16925	COG2072	flavoprotein involved in K transport
C2U31_16935	COG0384	phenazine biosynthesis protein PhzF
C2U31_16950	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_16970	COG1522	sequence-specific DNA binding
C2U31_17005	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_17045	COG0583	DNA-binding transcription factor activity
C2U31_17060	COG5265	(ABC) transporter
C2U31_17065	COG0656	L-ascorbic acid biosynthetic process
C2U31_17080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U31_17090	COG2207	Transcriptional regulator
C2U31_17095	COG2223	nitrite transmembrane transporter activity
C2U31_17105	COG1215	transferase activity, transferring glycosyl groups
C2U31_17110	COG0726	polysaccharide deacetylase
C2U31_17110	COG1649	PFAM Uncharacterised BCR, COG1649
C2U31_17115	COG0457	Tetratricopeptide repeat
C2U31_17120	COG2199	diguanylate cyclase activity
C2U31_17145	COG1610	YqeY-like protein
C2U31_17150	COG0583	DNA-binding transcription factor activity
C2U31_17155	COG1942	4-Oxalocrotonate Tautomerase
C2U31_17160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U31_17160	COG1017	nitric oxide dioxygenase activity
C2U31_17165	COG1959	2 iron, 2 sulfur cluster binding
C2U31_17170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_17180	COG0506	proline dehydrogenase activity
C2U31_17200	COG0583	DNA-binding transcription factor activity
C2U31_17210	COG0625	glutathione transferase activity
C2U31_17225	COG2814	Major facilitator Superfamily
C2U31_17230	COG1960	acyl-CoA dehydrogenase activity
C2U31_17235	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_17250	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2U31_17255	COG1280	lysine exporter protein (LysE YggA)
C2U31_17270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U31_17275	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2U31_17280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U31_17280	COG0515	serine threonine protein kinase
C2U31_17295	COG1280	lysine exporter protein (LysE YggA)
C2U31_17300	COG0406	alpha-ribazole phosphatase activity
C2U31_17320	COG0697	spore germination
C2U31_17325	COG0697	spore germination
C2U31_17340	COG0534	Mate efflux family protein
C2U31_17345	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C2U31_17355	COG2226	methyltransferase
C2U31_17360	COG1609	Transcriptional regulator
C2U31_17365	COG2271	Major facilitator Superfamily
C2U31_17370	COG0154	amidase activity
C2U31_17380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2U31_17415	COG2186	Transcriptional regulator
C2U31_17425	COG0307	riboflavin synthase, alpha
C2U31_17435	COG2271	Major facilitator Superfamily
C2U31_17445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U31_17450	COG4650	regulator
C2U31_17460	COG1690	Belongs to the RtcB family
C2U31_17465	COG3541	Predicted nucleotidyltransferase
C2U31_17480	COG0789	Transcriptional regulator
C2U31_17495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2U31_17500	COG3842	ATPase activity
C2U31_17505	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U31_17515	COG0726	polysaccharide deacetylase
C2U31_17520	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_17525	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_17530	COG0154	amidase activity
C2U31_17540	COG0022	dehydrogenase e1 component
C2U31_17560	COG2814	Major facilitator Superfamily
C2U31_17575	COG0165	Argininosuccinate lyase
C2U31_17580	COG0668	transmembrane transport
C2U31_17620	COG2233	PERMEase
C2U31_17625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U31_17650	COG0469	pyruvate kinase activity
C2U31_17660	COG2084	Dehydrogenase
C2U31_17665	COG3622	Belongs to the hyi family
C2U31_17670	COG3960	tartronate-semialdehyde synthase activity
C2U31_17675	COG0583	DNA-binding transcription factor activity
C2U31_17680	COG0154	amidase activity
C2U31_17685	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_17690	COG0583	DNA-binding transcription factor activity
C2U31_17725	COG2165	general secretion pathway protein
C2U31_17750	COG0583	DNA-binding transcription factor activity
C2U31_17765	COG0601	transmembrane transport
C2U31_17775	COG4172	Belongs to the ABC transporter superfamily
C2U31_17780	COG2207	Transcriptional regulator
C2U31_17790	COG1280	lysine exporter protein (LysE YggA)
C2U31_17795	COG4681	YaeQ
C2U31_17815	COG0477	Major facilitator Superfamily
C2U31_17820	COG3161	chorismate lyase activity
C2U31_17825	COG1187	pseudouridine synthase activity
C2U31_17845	COG1538	Outer membrane efflux protein
C2U31_17855	COG1999	signal sequence binding
C2U31_17865	COG0339	signal peptide processing
C2U31_17875	COG4566	intracellular signal transduction
C2U31_17890	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U31_17895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U31_17900	COG4804	nuclease activity
C2U31_17930	COG4797	methyltransferase
C2U31_17930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U31_17935	COG1191	sigma factor activity
C2U31_17970	COG0835	chemotaxis
C2U31_17975	COG0840	transmembrane signaling receptor activity
C2U31_17980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2U31_17985	COG2201	protein-glutamate methylesterase activity
C2U31_17990	COG0745	RESPONSE REGULATOR receiver
C2U31_17995	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C2U31_18010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2U31_18025	COG2747	anti-sigma28 factor FlgM
C2U31_18040	COG1558	bacterial-type flagellum-dependent cell motility
C2U31_18045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2U31_18050	COG1749	Flagellar hook protein flgE
C2U31_18055	COG4787	bacterial-type flagellum-dependent cell motility
C2U31_18060	COG4786	Flagellar basal body rod
C2U31_18065	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U31_18070	COG1706	bacterial-type flagellum-dependent cell motility
C2U31_18080	COG1256	bacterial-type flagellum assembly
C2U31_18090	COG0840	transmembrane signaling receptor activity
C2U31_18095	COG0840	transmembrane signaling receptor activity
C2U31_18105	COG0840	transmembrane signaling receptor activity
C2U31_18130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U31_18165	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U31_18170	COG1766	The M ring may be actively involved in energy transduction
C2U31_18175	COG1677	Flagellar hook-basal body complex protein FliE
C2U31_18185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2U31_18205	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2U31_18225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_18230	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_18240	COG0285	dihydrofolate synthase activity
C2U31_18260	COG1451	nucleotide metabolic process
C2U31_18270	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2U31_18280	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2U31_18285	COG0024	Methionine aminopeptidase
C2U31_18290	COG0052	Belongs to the universal ribosomal protein uS2 family
C2U31_18295	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2U31_18300	COG0528	UMP kinase activity
C2U31_18305	COG0233	cytoplasmic translational termination
C2U31_18310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2U31_18315	COG0575	Belongs to the CDS family
C2U31_18320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2U31_18325	COG0750	zinc metalloprotease
C2U31_18330	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U31_18335	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C2U31_18340	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U31_18345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U31_18355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U31_18360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2U31_18365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U31_18375	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2U31_18385	COG0477	Major facilitator Superfamily
C2U31_18390	COG0583	DNA-binding transcription factor activity
C2U31_18395	COG1309	transcriptional regulator
C2U31_18405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_18410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_18420	COG2169	Transcriptional regulator
C2U31_18420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U31_18425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U31_18425	COG0519	Catalyzes the synthesis of GMP from XMP
C2U31_18435	COG0330	HflC and HflK could
C2U31_18440	COG3706	GGDEF domain
C2U31_18445	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2U31_18450	COG2867	negative regulation of translational initiation
C2U31_18455	COG2914	Belongs to the UPF0125 (RnfH) family
C2U31_18460	COG1960	acyl-CoA dehydrogenase activity
C2U31_18465	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2U31_18490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U31_18495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2U31_18500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2U31_18505	COG0084	hydrolase, TatD family'
C2U31_18520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_18530	COG1126	abc transporter atp-binding protein
C2U31_18535	COG0010	Belongs to the arginase family
C2U31_18545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U31_18560	COG0095	Lipoate-protein ligase
C2U31_18575	COG0625	glutathione transferase activity
C2U31_18585	COG1522	sequence-specific DNA binding
C2U31_18590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2U31_18600	COG0386	Belongs to the glutathione peroxidase family
C2U31_18605	COG2814	Major facilitator Superfamily
C2U31_18635	COG0840	transmembrane signaling receptor activity
C2U31_18640	COG0415	Belongs to the DNA photolyase family
C2U31_18645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_18675	COG3949	Membrane
C2U31_18740	COG1522	sequence-specific DNA binding
C2U31_18745	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2U31_18765	COG0625	glutathione transferase activity
C2U31_18805	COG0513	Belongs to the DEAD box helicase family
C2U31_18815	COG4691	Plasmid stability protein
C2U31_18820	COG1414	Transcriptional regulator
C2U31_18840	COG1522	sequence-specific DNA binding
C2U31_18850	COG4166	transmembrane transport
C2U31_18855	COG0601	transmembrane transport
C2U31_18860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_18875	COG1228	amidohydrolase
C2U31_18895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_18900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_18905	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2U31_18910	COG4521	taurine ABC transporter
C2U31_18930	COG1414	Transcriptional regulator
C2U31_18935	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2U31_18940	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_18950	COG2721	sulfolactate sulfo-lyase activity
C2U31_18955	COG0765	amino acid transport
C2U31_18960	COG0765	amino acid transport
C2U31_18995	COG1966	Carbon starvation protein
C2U31_19000	COG2879	small protein
C2U31_19010	COG2837	iron assimilation
C2U31_19015	COG2814	Major facilitator Superfamily
C2U31_19025	COG1408	metallophosphoesterase
C2U31_19035	COG0688	phosphatidylethanolamine metabolic process
C2U31_19040	COG0488	(ABC) transporter
C2U31_19060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_19065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U31_19070	COG2203	Gaf domain
C2U31_19070	COG2200	EAL domain
C2U31_19070	COG2199	diguanylate cyclase activity
C2U31_19105	COG0783	Belongs to the Dps family
C2U31_19110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U31_19125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U31_19130	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
C2U31_19135	COG0745	RESPONSE REGULATOR receiver
C2U31_19140	COG5002	protein histidine kinase activity
C2U31_19150	COG3848	Pyruvate phosphate dikinase
C2U31_19150	COG0574	Belongs to the PEP-utilizing enzyme family
C2U31_19160	COG2070	2-Nitropropane dioxygenase
C2U31_19200	COG0583	DNA-binding transcription factor activity
C2U31_19210	COG0747	negative chemotaxis
C2U31_19215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_19225	COG2188	Transcriptional regulator
C2U31_19250	COG0410	ABC transporter
C2U31_19255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2U31_19260	COG0066	3-isopropylmalate dehydratase activity
C2U31_19280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2U31_19290	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C2U31_19295	COG0589	response to stress
C2U31_19315	COG2197	response regulator
C2U31_19330	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C2U31_19335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2U31_19355	COG0583	DNA-binding transcription factor activity
C2U31_19360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U31_19375	COG2223	nitrite transmembrane transporter activity
C2U31_19380	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2U31_19385	COG1140	nitrate reductase beta subunit
C2U31_19390	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2U31_19395	COG2181	nitrate reductase activity
C2U31_19400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U31_19405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U31_19410	COG0288	reversible hydration of carbon dioxide
C2U31_19415	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2U31_19420	COG3850	Histidine kinase
C2U31_19425	COG2197	response regulator
C2U31_19445	COG4221	oxidoreductase activity
C2U31_19450	COG4597	amino acid ABC transporter
C2U31_19455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_19475	COG4977	sequence-specific DNA binding
C2U31_19490	COG1116	anion transmembrane transporter activity
C2U31_19495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U31_19500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_19510	COG4771	TonB-dependent receptor
C2U31_19560	COG4774	siderophore transport
C2U31_19565	COG3971	2-oxopent-4-enoate hydratase activity
C2U31_19575	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_19580	COG0346	lactoylglutathione lyase activity
C2U31_19605	COG0477	Major facilitator Superfamily
C2U31_19655	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C2U31_19680	COG2814	Major facilitator Superfamily
C2U31_19685	COG2897	thiosulfate sulfurtransferase activity
C2U31_19710	COG4566	intracellular signal transduction
C2U31_19730	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2U31_19775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U31_19790	COG0583	DNA-binding transcription factor activity
C2U31_19795	COG1509	lysine 2,3-aminomutase activity
C2U31_19810	COG0625	glutathione transferase activity
C2U31_19840	COG0765	amino acid transport
C2U31_19845	COG1126	abc transporter atp-binding protein
C2U31_19885	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U31_19890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U31_19895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U31_19905	COG2814	Major facilitator Superfamily
C2U31_19945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U31_19950	COG0390	transport system, permease component
C2U31_19955	COG0586	Pfam SNARE associated Golgi protein
C2U31_19960	COG0534	Mate efflux family protein
C2U31_19970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U31_19985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U31_19995	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2U31_20010	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U31_20035	COG3971	2-oxopent-4-enoate hydratase activity
C2U31_20045	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2U31_20050	COG0625	glutathione transferase activity
C2U31_20070	COG2124	cytochrome p450
C2U31_20085	COG2192	nodulation
C2U31_20095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U31_20100	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_20140	COG2207	Transcriptional regulator
C2U31_20150	COG2072	flavoprotein involved in K transport
C2U31_20160	COG1454	alcohol dehydrogenase
C2U31_20165	COG0698	ribose 5-phosphate isomerase
C2U31_20170	COG1937	Protein conserved in bacteria
C2U31_20185	COG0589	response to stress
C2U31_20190	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C2U31_20195	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U31_20205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U31_20225	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U31_20250	COG0148	phosphopyruvate hydratase activity
C2U31_20275	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_20280	COG2814	Major facilitator Superfamily
C2U31_20310	COG1024	Enoyl-CoA hydratase
C2U31_20315	COG0596	Alpha beta hydrolase
C2U31_20330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U31_20350	COG3395	kinase activity
C2U31_20355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U31_20380	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2U31_20390	COG0789	Transcriptional regulator
C2U31_20400	COG1473	amidohydrolase
C2U31_20405	COG0583	DNA-binding transcription factor activity
C2U31_20420	COG3706	GGDEF domain
C2U31_20425	COG3706	GGDEF domain
C2U31_20490	COG1459	type II secretion system
C2U31_20525	COG1846	Transcriptional regulator
C2U31_20530	COG2807	transmembrane transport
C2U31_20545	COG1024	Enoyl-CoA hydratase
C2U31_20555	COG2205	protein histidine kinase activity
C2U31_20560	COG1253	flavin adenine dinucleotide binding
C2U31_20575	COG2199	diguanylate cyclase activity
C2U31_20575	COG2200	EAL domain
C2U31_20580	COG1289	transmembrane transporter activity
C2U31_20590	COG1464	Belongs to the NlpA lipoprotein family
C2U31_20605	COG2363	Small membrane protein
C2U31_20610	COG0697	spore germination
C2U31_20620	COG2133	pyrroloquinoline quinone binding
C2U31_20625	COG0625	glutathione transferase activity
C2U31_20635	COG0410	ABC transporter
C2U31_20650	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_20660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2U31_20670	COG1653	transport
C2U31_20675	COG1175	transmembrane transport
C2U31_20680	COG0395	ABC-type sugar transport system, permease component
C2U31_20685	COG3842	ATPase activity
C2U31_20700	COG2205	protein histidine kinase activity
C2U31_20705	COG0745	RESPONSE REGULATOR receiver
C2U31_20720	COG0783	Belongs to the Dps family
C2U31_20730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U31_20740	COG0583	DNA-binding transcription factor activity
C2U31_20765	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U31_20770	COG1178	ABC-type Fe3 transport system permease component
C2U31_20775	COG3842	ATPase activity
C2U31_20785	COG1690	Belongs to the RtcB family
C2U31_20790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C2U31_20795	COG1741	Belongs to the pirin family
C2U31_20800	COG1741	Belongs to the pirin family
C2U31_20805	COG0583	DNA-binding transcription factor activity
C2U31_20810	COG2204	response regulator
C2U31_20815	COG3852	Histidine kinase
C2U31_20830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U31_20835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2U31_20845	COG0840	transmembrane signaling receptor activity
C2U31_20850	COG1960	acyl-CoA dehydrogenase activity
C2U31_20860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2U31_20865	COG1561	YicC-like family, N-terminal region
C2U31_20890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_20900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_20905	COG1024	Enoyl-CoA hydratase
C2U31_20920	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_20925	COG0833	amino acid
C2U31_20930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U31_20935	COG0791	NLP P60 protein
C2U31_20940	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_20945	COG2863	cytochrome
C2U31_20950	COG3258	Cytochrome c
C2U31_20955	COG0194	GDP metabolic process
C2U31_20960	COG1758	RNA polymerase activity
C2U31_20965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U31_20970	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2U31_20990	COG2271	Major facilitator Superfamily
C2U31_20995	COG1126	abc transporter atp-binding protein
C2U31_21000	COG0765	amino acid transport
C2U31_21005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_21025	COG2816	NAD+ diphosphatase activity
C2U31_21045	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_21055	COG0411	ABC transporter
C2U31_21060	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U31_21065	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_21075	COG4336	lyase activity
C2U31_21080	COG0583	DNA-binding transcription factor activity
C2U31_21110	COG0583	DNA-binding transcription factor activity
C2U31_21120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U31_21125	COG0560	Phosphoserine phosphatase
C2U31_21130	COG0583	DNA-binding transcription factor activity
C2U31_21135	COG3842	ATPase activity
C2U31_21140	COG1178	ABC-type Fe3 transport system permease component
C2U31_21150	COG4181	ATPase activity
C2U31_21160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U31_21170	COG0584	glycerophosphoryl diester phosphodiesterase
C2U31_21175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U31_21185	COG5383	Protein conserved in bacteria
C2U31_21190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_21200	COG0678	peroxiredoxin activity
C2U31_21200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U31_21210	COG2217	Heavy metal translocating P-type atpase
C2U31_21220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U31_21245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U31_21250	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2U31_21255	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2U31_21260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2U31_21265	COG2252	PERMEase
C2U31_21270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U31_21275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U31_21305	COG2814	Major facilitator Superfamily
C2U31_21310	COG0488	(ABC) transporter
C2U31_21315	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2U31_21320	COG0590	tRNA wobble adenosine to inosine editing
C2U31_21335	COG1320	monovalent cation:proton antiporter activity
C2U31_21340	COG2212	antiporter activity
C2U31_21345	COG1863	multisubunit Na H antiporter MnhE subunit
C2U31_21350	COG0651	ATP synthesis coupled electron transport
C2U31_21355	COG1006	Multisubunit Na H antiporter MnhC subunit
C2U31_21360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2U31_21360	COG2111	Na H antiporter
C2U31_21390	COG0420	3'-5' exonuclease activity
C2U31_21395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_21425	COG1960	acyl-CoA dehydrogenase activity
C2U31_21445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_21450	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_21475	COG0395	ABC-type sugar transport system, permease component
C2U31_21485	COG3842	ATPase activity
C2U31_21490	COG3842	ATPase activity
C2U31_21525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U31_21550	COG1902	pentaerythritol trinitrate reductase activity
C2U31_21565	COG0602	queuosine metabolic process
C2U31_21570	COG0720	synthase
C2U31_21580	COG1289	transmembrane transporter activity
C2U31_21590	COG1566	PFAM secretion protein HlyD family protein
C2U31_21615	COG0411	ABC transporter
C2U31_21625	COG0154	amidase activity
C2U31_21635	COG0251	oxidation-reduction process
C2U31_21645	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_21660	COG0400	carboxylic ester hydrolase activity
C2U31_21665	COG0833	amino acid
C2U31_21670	COG0159	tryptophan synthase activity
C2U31_21675	COG0133	tryptophan synthase activity
C2U31_21685	COG1247	-acetyltransferase
C2U31_21690	COG0586	Pfam SNARE associated Golgi protein
C2U31_21730	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_21735	COG0531	amino acid
C2U31_21740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U31_21770	COG0587	DNA-directed DNA polymerase activity
C2U31_21820	COG0410	ABC transporter
C2U31_21830	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_21855	COG1414	Transcriptional regulator
C2U31_21870	COG0667	Aldo Keto reductase
C2U31_21875	COG1309	transcriptional regulator
C2U31_21895	COG1683	Conserved Protein
C2U31_21905	COG2207	Transcriptional regulator
C2U31_21925	COG1360	Flagellar Motor Protein
C2U31_21930	COG3795	YCII-related domain
C2U31_21940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U31_21945	COG3795	YCII-related domain
C2U31_21955	COG4941	Belongs to the sigma-70 factor family
C2U31_21960	COG2169	Transcriptional regulator
C2U31_21960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U31_21965	COG0697	spore germination
C2U31_22000	COG0456	acetyltransferase
C2U31_22010	COG1846	Transcriptional regulator
C2U31_22060	COG0024	Methionine aminopeptidase
C2U31_22070	COG0625	glutathione transferase activity
C2U31_22075	COG2733	membrane
C2U31_22085	COG0765	amino acid transport
C2U31_22090	COG0765	amino acid transport
C2U31_22130	COG0583	DNA-binding transcription factor activity
C2U31_22140	COG0183	Belongs to the thiolase family
C2U31_22145	COG1960	acyl-CoA dehydrogenase activity
C2U31_22150	COG1960	acyl-CoA dehydrogenase activity
C2U31_22155	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_22165	COG1464	Belongs to the NlpA lipoprotein family
C2U31_22225	COG1522	sequence-specific DNA binding
C2U31_22230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_22235	COG3842	ATPase activity
C2U31_22240	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U31_22245	COG4149	molybdate abc transporter
C2U31_22250	COG4251	negative regulation of phosphorylation
C2U31_22250	COG5001	Diguanylate cyclase
C2U31_22250	COG2203	Gaf domain
C2U31_22250	COG3706	GGDEF domain
C2U31_22255	COG2201	protein-glutamate methylesterase activity
C2U31_22285	COG0154	amidase activity
C2U31_22290	COG0583	DNA-binding transcription factor activity
C2U31_22325	COG0183	Belongs to the thiolase family
C2U31_22330	COG1960	acyl-CoA dehydrogenase activity
C2U31_22340	COG2030	dehydratase
C2U31_22345	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_22355	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_22380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_22385	COG1024	Enoyl-CoA hydratase
C2U31_22395	COG0456	acetyltransferase
C2U31_22410	COG0583	DNA-binding transcription factor activity
C2U31_22420	COG0183	Belongs to the thiolase family
C2U31_22425	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_22430	COG0477	Major facilitator Superfamily
C2U31_22445	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C2U31_22460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_22500	COG0251	oxidation-reduction process
C2U31_22535	COG1280	lysine exporter protein (LysE YggA)
C2U31_22550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U31_22550	COG2169	Transcriptional regulator
C2U31_22580	COG2084	Dehydrogenase
C2U31_22585	COG1309	transcriptional regulator
C2U31_22610	COG1960	acyl-CoA dehydrogenase activity
C2U31_22630	COG3719	Belongs to the RNase T2 family
C2U31_22640	COG4221	oxidoreductase activity
C2U31_22660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U31_22665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U31_22670	COG1802	Transcriptional regulator
C2U31_22725	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2U31_22735	COG0640	Transcriptional regulator
C2U31_22760	COG3246	L-lysine catabolic process to acetate
C2U31_22770	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C2U31_22775	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_22805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U31_22805	COG0519	Catalyzes the synthesis of GMP from XMP
C2U31_22835	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2U31_22855	COG2072	flavoprotein involved in K transport
C2U31_22860	COG0601	transmembrane transport
C2U31_22865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_22870	COG0444	Belongs to the ABC transporter superfamily
C2U31_22875	COG4608	Belongs to the ABC transporter superfamily
C2U31_22880	COG0747	negative chemotaxis
C2U31_22945	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
C2U31_22955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2U31_23010	COG0583	DNA-binding transcription factor activity
C2U31_23020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_23030	COG0477	Major facilitator Superfamily
C2U31_23110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U31_23135	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U31_23135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U31_23150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2U31_23175	COG1132	(ABC) transporter
C2U31_23190	COG5265	(ABC) transporter
C2U31_23195	COG1280	lysine exporter protein (LysE YggA)
C2U31_23230	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_23245	COG0494	nUDIX hydrolase
C2U31_23255	COG0583	DNA-binding transcription factor activity
C2U31_23260	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_23275	COG1024	Enoyl-CoA hydratase
C2U31_23280	COG5001	Diguanylate cyclase
C2U31_23290	COG0129	dihydroxy-acid dehydratase activity
C2U31_23310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_23340	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C2U31_23360	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U31_23365	COG1335	isochorismatase
C2U31_23370	COG2309	aminopeptidase activity
C2U31_23375	COG0596	Alpha beta hydrolase
C2U31_23400	COG0583	DNA-binding transcription factor activity
C2U31_23405	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_23410	COG3246	L-lysine catabolic process to acetate
C2U31_23430	COG3043	anaerobic respiration
C2U31_23435	COG3005	denitrification pathway
C2U31_23440	COG4133	protoheme IX ABC transporter activity
C2U31_23460	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C2U31_23470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U31_23475	COG3088	subunit of a heme lyase
C2U31_23490	COG3214	Protein conserved in bacteria
C2U31_23495	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_23505	COG0789	Transcriptional regulator
C2U31_23510	COG2814	Major facilitator Superfamily
C2U31_23555	COG0613	PHP domain protein
C2U31_23565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U31_23575	COG0583	DNA-binding transcription factor activity
C2U31_23595	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C2U31_23620	COG1304	FMN binding
C2U31_23630	COG0737	Belongs to the 5'-nucleotidase family
C2U31_23635	COG4604	ABC transporter, ATP-binding protein
C2U31_23640	COG4605	iron ion homeostasis
C2U31_23645	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U31_23650	COG4607	ABC-type enterochelin transport system periplasmic component
C2U31_23655	COG4771	TonB-dependent receptor
C2U31_23660	COG0745	RESPONSE REGULATOR receiver
C2U31_23670	COG4771	TonB-dependent receptor
C2U31_23675	COG0084	hydrolase, TatD family'
C2U31_23680	COG1136	(ABC) transporter
C2U31_23700	COG2271	Major facilitator Superfamily
C2U31_23710	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_23715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2U31_23725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_23730	COG0243	molybdopterin cofactor binding
C2U31_23740	COG0183	Belongs to the thiolase family
C2U31_23745	COG1022	Amp-dependent synthetase and ligase
C2U31_23750	COG0410	ABC transporter
C2U31_23795	COG1803	Methylglyoxal synthase
C2U31_23800	COG2975	iron-sulfur cluster assembly
C2U31_23810	COG0443	Heat shock 70 kDa protein
C2U31_23815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U31_23820	COG0316	Belongs to the HesB IscA family
C2U31_23825	COG0822	iron-sulfur transferase activity
C2U31_23830	COG1104	cysteine desulfurase activity
C2U31_23840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2U31_23845	COG0556	nucleotide-excision repair
C2U31_23855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U31_23860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U31_23865	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2U31_23870	COG0740	serine-type endopeptidase activity
C2U31_23875	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2U31_23880	COG0501	Belongs to the peptidase M48B family
C2U31_23895	COG1278	Cold shock
C2U31_23905	COG1278	Cold shock
C2U31_23930	COG0251	oxidation-reduction process
C2U31_23940	COG0583	DNA-binding transcription factor activity
C2U31_23955	COG1309	transcriptional regulator
C2U31_23975	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2U31_23980	COG3038	cytochrome b561
C2U31_23985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U31_24015	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_24020	COG0174	glutamine synthetase
C2U31_24050	COG0436	Aminotransferase
C2U31_24055	COG2171	N-acyltransferase activity
C2U31_24065	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U31_24070	COG0488	(ABC) transporter
C2U31_24085	COG4771	TonB-dependent receptor
C2U31_24100	COG0210	DNA helicase
C2U31_24115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U31_24115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U31_24125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U31_24130	COG0196	riboflavin kinase activity
C2U31_24135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2U31_24140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2U31_24145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U31_24165	COG2197	response regulator
C2U31_24185	COG3121	Chaperone
C2U31_24190	COG3188	usher protein
C2U31_24195	COG3121	Chaperone
C2U31_24225	COG1902	pentaerythritol trinitrate reductase activity
C2U31_24230	COG1126	abc transporter atp-binding protein
C2U31_24235	COG0765	amino acid transport
C2U31_24240	COG0765	amino acid transport
C2U31_24245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_24255	COG2423	ornithine cyclodeaminase activity
C2U31_24260	COG1764	response to oxidative stress
C2U31_24265	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U31_24280	COG2271	Major facilitator Superfamily
C2U31_24290	COG1309	transcriptional regulator
C2U31_24300	COG0411	ABC transporter
C2U31_24310	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_24320	COG0506	proline dehydrogenase activity
C2U31_24320	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U31_24320	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U31_24330	COG3008	intermembrane lipid transfer
C2U31_24335	COG2995	paraquat-inducible protein a
C2U31_24340	COG0542	response to heat
C2U31_24345	COG4953	penicillin-binding protein 1C
C2U31_24350	COG2373	Large extracellular alpha-helical protein
C2U31_24355	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2U31_24360	COG1278	Cold shock
C2U31_24370	COG0183	Belongs to the thiolase family
C2U31_24385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2U31_24395	COG1570	exodeoxyribonuclease VII activity
C2U31_24400	COG0811	peptide transport
C2U31_24410	COG1663	tetraacyldisaccharide 4'-kinase activity
C2U31_24420	COG2835	tetraacyldisaccharide 4'-kinase activity
C2U31_24425	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2U31_24430	COG0563	adenylate kinase activity
C2U31_24440	COG0728	peptidoglycan biosynthetic process
C2U31_24450	COG0268	Binds directly to 16S ribosomal RNA
C2U31_24455	COG0583	DNA-binding transcription factor activity
C2U31_24460	COG0019	diaminopimelate decarboxylase activity
C2U31_24470	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_24480	COG2186	Transcriptional regulator
C2U31_24495	COG2814	Major facilitator Superfamily
C2U31_24500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U31_24510	COG0439	Biotin carboxylase
C2U31_24515	COG0511	ligase activity, forming carbon-carbon bonds
C2U31_24520	COG0511	ligase activity, forming carbon-carbon bonds
C2U31_24520	COG5016	pyruvate
C2U31_24530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U31_24555	COG1846	Transcriptional regulator
C2U31_24560	COG3384	dioxygenase
C2U31_24565	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_24580	COG3971	2-oxopent-4-enoate hydratase activity
C2U31_24590	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_24595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U31_24605	COG1562	ergosterol biosynthetic process
C2U31_24610	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C2U31_24615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2U31_24635	COG1477	protein flavinylation
C2U31_24640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U31_24650	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2U31_24655	COG0583	DNA-binding transcription factor activity
C2U31_24665	COG5564	TIM-barrel signal transduction protein
C2U31_24670	COG5441	Belongs to the UPF0261 family
C2U31_24700	COG1802	Transcriptional regulator
C2U31_24710	COG0747	negative chemotaxis
C2U31_24735	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U31_24745	COG0542	response to heat
C2U31_24755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U31_24765	COG0477	Major facilitator Superfamily
C2U31_24775	COG0494	nUDIX hydrolase
C2U31_24790	COG0443	Heat shock 70 kDa protein
C2U31_24805	COG2197	response regulator
C2U31_24810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U31_24830	COG0028	Belongs to the TPP enzyme family
C2U31_24840	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_24845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U31_24855	COG0601	transmembrane transport
C2U31_24860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_24865	COG4172	Belongs to the ABC transporter superfamily
C2U31_24885	COG1609	Transcriptional regulator
C2U31_24890	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C2U31_24895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C2U31_24900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2U31_24905	COG0129	dihydroxy-acid dehydratase activity
C2U31_24920	COG1051	belongs to the nudix hydrolase family
C2U31_24950	COG0135	phosphoribosylanthranilate isomerase activity
C2U31_24955	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C2U31_24960	COG0101	tRNA pseudouridine synthase activity
C2U31_24970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U31_24975	COG0473	3-isopropylmalate dehydrogenase activity
C2U31_24980	COG0066	3-isopropylmalate dehydratase activity
C2U31_24985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2U31_24990	COG1538	Outer membrane efflux protein
C2U31_25000	COG2274	protein secretion by the type I secretion system
C2U31_25005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_25030	COG0583	DNA-binding transcription factor activity
C2U31_25035	COG2267	carboxylic ester hydrolase activity
C2U31_25040	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_25045	COG4783	chaperone-mediated protein folding
C2U31_25050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2U31_25065	COG2205	protein histidine kinase activity
C2U31_25075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2U31_25085	COG1295	ribonuclease BN
C2U31_25095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U31_25125	COG4964	Belongs to the GSP D family
C2U31_25160	COG0640	Transcriptional regulator
C2U31_25165	COG2755	lipolytic protein G-D-S-L family
C2U31_25165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2U31_25170	COG4977	sequence-specific DNA binding
C2U31_25185	COG2205	protein histidine kinase activity
C2U31_25195	COG2205	protein histidine kinase activity
C2U31_25200	COG0745	RESPONSE REGULATOR receiver
C2U31_25220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_25230	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2U31_25305	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2U31_25315	COG1609	Transcriptional regulator
C2U31_25320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U31_25320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U31_25325	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U31_25330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U31_25330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U31_25340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2U31_25345	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C2U31_25350	COG0330	HflC and HflK could
C2U31_25355	COG0330	HflC and HflK could
C2U31_25360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U31_25365	COG1923	regulation of RNA biosynthetic process
C2U31_25375	COG1160	GTP binding
C2U31_25380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U31_25385	COG2976	Protein conserved in bacteria
C2U31_25390	COG0124	histidyl-tRNA synthetase
C2U31_25395	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2U31_25405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2U31_25410	COG0105	UTP biosynthetic process
C2U31_25415	COG0525	valine-tRNA ligase activity
C2U31_25420	COG0336	Belongs to the RNA methyltransferase TrmD family
C2U31_25425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2U31_25430	COG0228	four-way junction DNA binding
C2U31_25435	COG0425	Belongs to the sulfur carrier protein TusA family
C2U31_25440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U31_25455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_25465	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2U31_25470	COG2076	Multidrug Resistance protein
C2U31_25475	COG0633	Ferredoxin
C2U31_25475	COG3217	Mosc domain protein beta barrel domain protein
C2U31_25480	COG5285	phytanoyl-CoA dioxygenase
C2U31_25485	COG0662	Cupin 2, conserved barrel domain protein
C2U31_25490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U31_25495	COG0456	acetyltransferase
C2U31_25510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2U31_25515	COG2311	Membrane
C2U31_25535	COG0187	DNA topoisomerase II activity
C2U31_25545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2U31_25560	COG1902	pentaerythritol trinitrate reductase activity
C2U31_25560	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U31_25565	COG2181	nitrate reductase activity
C2U31_25565	COG0247	lactate metabolic process
C2U31_25570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2U31_25595	COG1063	alcohol dehydrogenase
C2U31_25600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U31_25610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U31_25635	COG0625	glutathione transferase activity
C2U31_25640	COG0477	Major facilitator Superfamily
C2U31_25655	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2U31_25660	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2U31_25680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U31_25690	COG3391	amine dehydrogenase activity
C2U31_25710	COG0697	spore germination
C2U31_25720	COG1846	Transcriptional regulator
C2U31_25730	COG1566	PFAM secretion protein HlyD family protein
C2U31_25735	COG2814	Major facilitator Superfamily
C2U31_25745	COG0473	3-isopropylmalate dehydrogenase activity
C2U31_25750	COG0433	COG0433 Predicted ATPase
C2U31_25755	COG0217	transcriptional regulatory protein
C2U31_25760	COG0151	Belongs to the GarS family
C2U31_25765	COG0408	coproporphyrinogen oxidase activity
C2U31_25770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2U31_25775	COG0799	negative regulation of ribosome biogenesis
C2U31_25780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2U31_25785	COG0424	maF-like protein
C2U31_25790	COG1301	dicarboxylic acid transport
C2U31_25795	COG4191	Histidine kinase
C2U31_25800	COG2204	response regulator
C2U31_25815	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2U31_25820	COG2885	chlorophyll binding
C2U31_25820	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2U31_25825	COG3384	dioxygenase
C2U31_25840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2U31_25895	COG4964	Belongs to the GSP D family
C2U31_25945	COG1846	Transcriptional regulator
C2U31_25955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_25960	COG0601	transmembrane transport
C2U31_25975	COG0598	Magnesium transport protein CorA
C2U31_25995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U31_26020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U31_26025	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_26035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U31_26040	COG1045	serine acetyltransferase
C2U31_26045	COG0166	Belongs to the GPI family
C2U31_26055	COG3206	protein involved in exopolysaccharide biosynthesis
C2U31_26055	COG0489	protein tyrosine kinase activity
C2U31_26065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2U31_26090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U31_26115	COG0463	Glycosyl transferase, family 2
C2U31_26120	COG0110	maltose O-acetyltransferase activity
C2U31_26125	COG0297	glycogen (starch) synthase activity
C2U31_26130	COG2197	response regulator
C2U31_26135	COG2197	response regulator
C2U31_26150	COG1960	acyl-CoA dehydrogenase activity
C2U31_26160	COG1024	Enoyl-CoA hydratase
C2U31_26160	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_26170	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_26170	COG1024	Enoyl-CoA hydratase
C2U31_26175	COG0183	Belongs to the thiolase family
C2U31_26190	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_26200	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_26210	COG1132	(ABC) transporter
C2U31_26215	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_26220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U31_26225	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2U31_26230	COG1024	Enoyl-CoA hydratase
C2U31_26240	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_26250	COG1414	Transcriptional regulator
C2U31_26260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U31_26280	COG0583	DNA-binding transcription factor activity
C2U31_26290	COG0456	acetyltransferase
C2U31_26325	COG0037	tRNA processing
C2U31_26330	COG0825	malonyl-CoA metabolic process
C2U31_26340	COG0215	cysteine-tRNA ligase activity
C2U31_26350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U31_26355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U31_26365	COG1968	undecaprenyl-diphosphatase activity
C2U31_26370	COG1253	flavin adenine dinucleotide binding
C2U31_26375	COG1253	flavin adenine dinucleotide binding
C2U31_26385	COG4263	nitrous-oxide reductase activity
C2U31_26400	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2U31_26440	COG0668	transmembrane transport
C2U31_26475	COG0431	NADPH-dependent FMN reductase
C2U31_26485	COG3360	Dodecin
C2U31_26495	COG0583	DNA-binding transcription factor activity
C2U31_26500	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_26615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2U31_26620	COG2850	peptidyl-arginine hydroxylation
C2U31_26630	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2U31_26635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_26640	COG1994	Peptidase M50
C2U31_26645	COG0009	L-threonylcarbamoyladenylate synthase
C2U31_26650	COG2321	neutral zinc metallopeptidase
C2U31_26685	COG2808	Putative FMN-binding domain
C2U31_26700	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2U31_26730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U31_26735	COG2084	Dehydrogenase
C2U31_26760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U31_26765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_26795	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C2U31_26800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U31_26815	COG2072	flavoprotein involved in K transport
C2U31_26845	COG0765	amino acid transport
C2U31_26860	COG1126	abc transporter atp-binding protein
C2U31_26865	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_26870	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
C2U31_26875	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2U31_26890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U31_26960	COG1396	sequence-specific DNA binding
C2U31_26965	COG0235	Class ii aldolase
C2U31_26975	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_26990	COG1309	transcriptional regulator
C2U31_27000	COG1785	Belongs to the alkaline phosphatase family
C2U31_27065	COG1917	Cupin 2, conserved barrel domain protein
C2U31_27080	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_27090	COG1137	ATPase activity
C2U31_27095	COG0410	ABC transporter
C2U31_27105	COG0431	NADPH-dependent FMN reductase
C2U31_27110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U31_27115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U31_27120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U31_27135	COG0436	Aminotransferase
C2U31_27140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U31_27185	COG0668	transmembrane transport
C2U31_27190	COG0745	RESPONSE REGULATOR receiver
C2U31_27215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_27265	COG1136	(ABC) transporter
C2U31_27265	COG0577	efflux transmembrane transporter activity
C2U31_27280	COG2205	protein histidine kinase activity
C2U31_27285	COG0745	RESPONSE REGULATOR receiver
C2U31_27305	COG3842	ATPase activity
C2U31_27310	COG4208	sulfate ABC transporter
C2U31_27315	COG0583	DNA-binding transcription factor activity
C2U31_27320	COG1595	DNA-templated transcription, initiation
C2U31_27325	COG3712	iron ion homeostasis
C2U31_27330	COG4774	siderophore transport
C2U31_27340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U31_27345	COG3958	Transketolase
C2U31_27350	COG3959	Transketolase, thiamine diphosphate binding domain
C2U31_27355	COG1802	Transcriptional regulator
C2U31_27360	COG0371	Dehydrogenase
C2U31_27365	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_27395	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_27400	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2U31_27410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_27420	COG0500	methyltransferase
C2U31_27425	COG1595	DNA-templated transcription, initiation
C2U31_27435	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C2U31_27455	COG0667	Aldo Keto reductase
C2U31_27460	COG2207	Transcriptional regulator
C2U31_27480	COG1126	abc transporter atp-binding protein
C2U31_27490	COG0251	oxidation-reduction process
C2U31_27500	COG1609	Transcriptional regulator
C2U31_27505	COG0583	DNA-binding transcription factor activity
C2U31_27510	COG1335	isochorismatase
C2U31_27545	COG0583	DNA-binding transcription factor activity
C2U31_27550	COG2814	Major facilitator Superfamily
C2U31_27585	COG1522	sequence-specific DNA binding
C2U31_27590	COG2423	ornithine cyclodeaminase activity
C2U31_27600	COG5001	Diguanylate cyclase
C2U31_27600	COG4251	negative regulation of phosphorylation
C2U31_27600	COG3706	GGDEF domain
C2U31_27600	COG2203	Gaf domain
C2U31_27610	COG0477	Major facilitator Superfamily
C2U31_27625	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_27630	COG0477	Major facilitator Superfamily
C2U31_27640	COG0583	DNA-binding transcription factor activity
C2U31_27650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2U31_27685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U31_27695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U31_27700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2U31_27705	COG1534	Rna-binding protein
C2U31_27710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U31_27715	COG0840	transmembrane signaling receptor activity
C2U31_27720	COG2233	PERMEase
C2U31_27740	COG0300	oxidoreductase activity
C2U31_27750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2U31_27755	COG0505	Belongs to the CarA family
C2U31_27760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U31_27770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_27780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U31_27785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_27790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2U31_27800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2U31_27820	COG1074	ATP-dependent DNA helicase activity
C2U31_27840	COG1686	Belongs to the peptidase S11 family
C2U31_27860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U31_27865	COG4974	Belongs to the 'phage' integrase family
C2U31_27875	COG0028	Belongs to the TPP enzyme family
C2U31_27890	COG2030	dehydratase
C2U31_27895	COG0028	Belongs to the TPP enzyme family
C2U31_27900	COG1126	abc transporter atp-binding protein
C2U31_27905	COG0765	amino acid transport
C2U31_27925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_27965	COG0583	DNA-binding transcription factor activity
C2U31_27970	COG0427	acetyl-CoA hydrolase
C2U31_27975	COG0583	DNA-binding transcription factor activity
C2U31_27980	COG3264	Mechanosensitive ion channel
C2U31_27980	COG1511	domain protein
C2U31_28010	COG2176	DNA-directed DNA polymerase activity
C2U31_28035	COG3842	ATPase activity
C2U31_28040	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U31_28050	COG3938	Belongs to the proline racemase family
C2U31_28055	COG0517	IMP dehydrogenase activity
C2U31_28095	COG0009	L-threonylcarbamoyladenylate synthase
C2U31_28100	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U31_28105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2U31_28110	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2U31_28115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2U31_28135	COG1301	dicarboxylic acid transport
C2U31_28150	COG3454	Phosphonate metabolism
C2U31_28155	COG4778	phosphonate C-P lyase system protein PhnL
C2U31_28160	COG4107	phosphonate C-P lyase system protein PhnK
C2U31_28165	COG3627	carbon phosphorus lyase activity
C2U31_28170	COG3626	phosphonate metabolism
C2U31_28180	COG3624	Phosphonate C-P lyase system protein PhnG
C2U31_28185	COG2188	Transcriptional regulator
C2U31_28190	COG3454	Phosphonate metabolism
C2U31_28195	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C2U31_28200	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C2U31_28205	COG0583	DNA-binding transcription factor activity
C2U31_28215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U31_28230	COG3253	May function as heme-dependent peroxidase
C2U31_28245	COG0405	Gamma-glutamyltransferase
C2U31_28260	COG3639	organic phosphonate transmembrane transporter activity
C2U31_28265	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C2U31_28270	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C2U31_28290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2U31_28300	COG0739	heme binding
C2U31_28310	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U31_28315	COG0306	phosphate transporter
C2U31_28345	COG0454	-acetyltransferase
C2U31_28345	COG0456	acetyltransferase
C2U31_28355	COG0625	glutathione transferase activity
C2U31_28375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U31_28380	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U31_28390	COG0126	phosphoglycerate kinase activity
C2U31_28395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U31_28400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U31_28410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U31_28415	COG2732	(Barnase) inhibitor
C2U31_28425	COG0280	phosphate acetyltransferase
C2U31_28425	COG0281	malic enzyme
C2U31_28440	COG0741	lytic transglycosylase activity
C2U31_28445	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2U31_28480	COG4575	ribosome binding
C2U31_28490	COG0243	molybdopterin cofactor binding
C2U31_28500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U31_28505	COG1116	anion transmembrane transporter activity
C2U31_28510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_28515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U31_28525	COG1648	precorrin-2 dehydrogenase activity
C2U31_28525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U31_28530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2U31_28535	COG2027	D-alanyl-D-alanine carboxypeptidase
C2U31_28550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U31_28560	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2U31_28565	COG0343	queuine tRNA-ribosyltransferase activity
C2U31_28570	COG1862	Preprotein translocase
C2U31_28575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U31_28580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U31_28605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U31_28615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U31_28620	COG1702	phosphate starvation-inducible protein PhoH
C2U31_28625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2U31_28630	COG4535	Mg2 and Co2 transporter CorC
C2U31_28635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2U31_28640	COG0667	Aldo Keto reductase
C2U31_28675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U31_28680	COG0697	spore germination
C2U31_28690	COG0678	peroxiredoxin activity
C2U31_28700	COG0412	Dienelactone hydrolase
C2U31_28710	COG0315	cyclic pyranopterin monophosphate synthase activity
C2U31_28725	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U31_28735	COG0746	molybdenum cofactor guanylyltransferase activity
C2U31_28740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U31_28760	COG3383	formate dehydrogenase (NAD+) activity
C2U31_28765	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U31_28780	COG2161	toxin-antitoxin pair type II binding
C2U31_28805	COG0583	DNA-binding transcription factor activity
C2U31_28810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2U31_28830	COG0745	RESPONSE REGULATOR receiver
C2U31_28845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U31_28855	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_28875	COG2828	Protein conserved in bacteria
C2U31_28880	COG0583	DNA-binding transcription factor activity
C2U31_28885	COG0456	acetyltransferase
C2U31_28925	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_28940	COG0410	ABC transporter
C2U31_28950	COG4774	siderophore transport
C2U31_28970	COG4585	Histidine kinase
C2U31_28975	COG0671	phosphoesterase, PA-phosphatase related
C2U31_28980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U31_28985	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2U31_28990	COG1666	GTP binding
C2U31_29000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U31_29005	COG4558	Periplasmic binding protein
C2U31_29010	COG3720	iron ion transport
C2U31_29020	COG3712	iron ion homeostasis
C2U31_29025	COG1595	DNA-templated transcription, initiation
C2U31_29040	COG2378	regulation of single-species biofilm formation
C2U31_29070	COG1113	amino acid transport
C2U31_29080	COG1522	sequence-specific DNA binding
C2U31_29085	COG1272	protein, Hemolysin III
C2U31_29090	COG3191	aminopeptidase activity
C2U31_29095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_29100	COG0765	amino acid transport
C2U31_29105	COG1126	abc transporter atp-binding protein
C2U31_29110	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_29150	COG1999	signal sequence binding
C2U31_29170	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C2U31_29180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U31_29185	COG1845	cytochrome c oxidase, subunit III
C2U31_29190	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U31_29230	COG0281	malic enzyme
C2U31_29230	COG0280	phosphate acetyltransferase
C2U31_29245	COG0697	spore germination
C2U31_29265	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_29270	COG2267	carboxylic ester hydrolase activity
C2U31_29290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U31_29305	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_29310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U31_29335	COG1309	transcriptional regulator
C2U31_29345	COG5001	Diguanylate cyclase
C2U31_29350	COG0330	HflC and HflK could
C2U31_29365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_29370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_29395	COG2807	transmembrane transport
C2U31_29400	COG2207	Transcriptional regulator
C2U31_29405	COG4106	trans-aconitate 2-methyltransferase activity
C2U31_29420	COG0583	DNA-binding transcription factor activity
C2U31_29455	COG0477	Major facilitator Superfamily
C2U31_29460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U31_29465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U31_29470	COG1845	cytochrome c oxidase, subunit III
C2U31_29475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U31_29480	COG3346	SURF1 family
C2U31_29515	COG0625	glutathione transferase activity
C2U31_29540	COG0784	Response regulator, receiver
C2U31_29540	COG2205	protein histidine kinase activity
C2U31_29545	COG0745	RESPONSE REGULATOR receiver
C2U31_29555	COG2197	response regulator
C2U31_29560	COG3161	chorismate lyase activity
C2U31_29610	COG0006	proline dipeptidase activity
C2U31_29615	COG0583	DNA-binding transcription factor activity
C2U31_29625	COG0667	Aldo Keto reductase
C2U31_29630	COG0023	Translation Initiation Factor
C2U31_29645	COG0840	transmembrane signaling receptor activity
C2U31_29650	COG0840	transmembrane signaling receptor activity
C2U31_29655	COG2706	6-phosphogluconolactonase activity
C2U31_29660	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_29680	COG1402	creatininase
C2U31_29695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U31_29730	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U31_29740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2U31_29745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_29750	COG0697	spore germination
C2U31_29805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_29810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_29870	COG2197	response regulator
C2U31_29905	COG4172	Belongs to the ABC transporter superfamily
C2U31_29910	COG0444	Belongs to the ABC transporter superfamily
C2U31_29920	COG0601	transmembrane transport
C2U31_29925	COG0747	negative chemotaxis
C2U31_29965	COG3485	protocatechuate 3,4-dioxygenase
C2U31_30000	COG1733	regulation of RNA biosynthetic process
C2U31_30015	COG4948	Mandelate Racemase Muconate Lactonizing
C2U31_30020	COG2197	response regulator
C2U31_30030	COG2814	Major facilitator Superfamily
C2U31_30050	COG3246	L-lysine catabolic process to acetate
C2U31_30055	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_30115	COG1595	DNA-templated transcription, initiation
C2U31_30125	COG2807	transmembrane transport
C2U31_30130	COG0590	tRNA wobble adenosine to inosine editing
C2U31_30140	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_30145	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U31_30150	COG4948	Mandelate Racemase Muconate Lactonizing
C2U31_30175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U31_30205	COG2124	cytochrome p450
C2U31_30225	COG2204	response regulator
C2U31_30230	COG2610	gluconate transmembrane transporter activity
C2U31_30235	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_30265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2U31_30270	COG0459	protein refolding
C2U31_30285	COG0246	Mannitol dehydrogenase
C2U31_30290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2U31_30295	COG1252	NADH dehydrogenase
C2U31_30300	COG0284	orotidine-5'-phosphate decarboxylase activity
C2U31_30305	COG1546	Belongs to the CinA family
C2U31_30320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U31_30325	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity