locus-tag	class	description
CVS48_00035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVS48_00045	COG1185	polyribonucleotide nucleotidyltransferase activity
CVS48_00050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CVS48_00060	COG1183	phosphatidylcholine synthase activity
CVS48_00065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CVS48_00070	COG0440	acetolactate synthase activity
CVS48_00075	COG0028	Belongs to the TPP enzyme family
CVS48_00080	COG1289	transmembrane transporter activity
CVS48_00090	COG3022	response to hydroperoxide
CVS48_00095	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_00125	COG4325	translation initiation factor activity
CVS48_00130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CVS48_00135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVS48_00140	COG0477	Major facilitator Superfamily
CVS48_00190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CVS48_00195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CVS48_00200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVS48_00210	COG0747	negative chemotaxis
CVS48_00215	COG0601	transmembrane transport
CVS48_00235	COG1737	Transcriptional regulator
CVS48_00240	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CVS48_00245	COG0251	oxidation-reduction process
CVS48_00250	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CVS48_00255	COG1674	ftsk spoiiie
CVS48_00260	COG0492	ferredoxin-NADP+ reductase activity
CVS48_00265	COG1193	negative regulation of DNA recombination
CVS48_00285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVS48_00305	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CVS48_00310	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CVS48_00315	COG2205	protein histidine kinase activity
CVS48_00320	COG0745	RESPONSE REGULATOR receiver
CVS48_00335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_00340	COG0840	transmembrane signaling receptor activity
CVS48_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVS48_00395	COG0612	Peptidase, M16
CVS48_00410	COG0484	heat shock protein binding
CVS48_00415	COG0443	Heat shock 70 kDa protein
CVS48_00425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CVS48_00435	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CVS48_00440	COG1420	regulation of RNA biosynthetic process
CVS48_00445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CVS48_00450	COG0497	DNA recombination
CVS48_00455	COG0735	belongs to the Fur family
CVS48_00460	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS48_00465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CVS48_00480	COG0582	viral genome integration into host DNA
CVS48_00530	COG0745	RESPONSE REGULATOR receiver
CVS48_00535	COG5002	protein histidine kinase activity
CVS48_00545	COG0640	Transcriptional regulator
CVS48_00560	COG0798	PFAM Bile acid sodium symporter
CVS48_00570	COG1695	Transcriptional regulator
CVS48_00650	COG2003	Belongs to the UPF0758 family
CVS48_00705	COG3311	Transcriptional regulator
CVS48_00710	COG1569	PIN domain
CVS48_00715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVS48_00865	COG0789	Transcriptional regulator
CVS48_00910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CVS48_00920	COG0789	Transcriptional regulator
CVS48_00935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CVS48_00940	COG0629	single-stranded DNA binding
CVS48_00975	COG1192	Involved in chromosome partitioning
CVS48_01000	COG3397	chitin binding
CVS48_01005	COG3397	chitin binding
CVS48_01015	COG2205	protein histidine kinase activity
CVS48_01020	COG0745	RESPONSE REGULATOR receiver
CVS48_01035	COG2165	general secretion pathway protein
CVS48_01040	COG1450	Type ii and iii secretion system protein
CVS48_01070	COG1459	type II secretion system
CVS48_01110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CVS48_01110	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS48_01125	COG1063	alcohol dehydrogenase
CVS48_01150	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CVS48_01155	COG2181	nitrate reductase activity
CVS48_01155	COG0247	lactate metabolic process
CVS48_01160	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS48_01160	COG1902	pentaerythritol trinitrate reductase activity
CVS48_01175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CVS48_01195	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_01210	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_01280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CVS48_01285	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CVS48_01290	COG0167	dihydroorotate dehydrogenase activity
CVS48_01305	COG1414	Transcriptional regulator
CVS48_01310	COG1546	Belongs to the CinA family
CVS48_01310	COG1058	Belongs to the CinA family
CVS48_01325	COG0513	Belongs to the DEAD box helicase family
CVS48_01350	COG0429	hydrolase of the alpha beta-hydrolase fold
CVS48_01355	COG4783	chaperone-mediated protein folding
CVS48_01375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CVS48_01390	COG0006	proline dipeptidase activity
CVS48_01400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS48_01420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CVS48_01425	COG0632	four-way junction helicase activity
CVS48_01430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CVS48_01440	COG2255	four-way junction helicase activity
CVS48_01445	COG4191	Histidine kinase
CVS48_01450	COG0745	RESPONSE REGULATOR receiver
CVS48_01460	COG0514	ATP-dependent DNA helicase (RecQ)
CVS48_01470	COG1271	oxidase subunit
CVS48_01475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS48_01480	COG0850	regulation of cytokinetic process
CVS48_01485	COG2894	cell division
CVS48_01490	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CVS48_01515	COG0488	(ABC) transporter
CVS48_01530	COG4608	Belongs to the ABC transporter superfamily
CVS48_01535	COG0444	Belongs to the ABC transporter superfamily
CVS48_01540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_01550	COG0747	negative chemotaxis
CVS48_01575	COG4638	Rieske (2fe-2S)
CVS48_01600	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CVS48_01605	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_01620	COG0411	ABC transporter
CVS48_01625	COG0410	ABC transporter
CVS48_01630	COG1216	Glycosyl transferase, family 2
CVS48_01630	COG0463	Glycosyl transferase, family 2
CVS48_01645	COG0800	Aldolase
CVS48_01655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CVS48_01695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CVS48_01700	COG1538	Outer membrane efflux protein
CVS48_01705	COG0577	efflux transmembrane transporter activity
CVS48_01705	COG1136	(ABC) transporter
CVS48_01710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS48_01725	COG0259	pyridoxamine-phosphate oxidase activity
CVS48_01730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CVS48_01735	COG0579	oxidoreductase
CVS48_01745	COG0583	DNA-binding transcription factor activity
CVS48_01750	COG1960	acyl-CoA dehydrogenase activity
CVS48_01755	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_01760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_01765	COG0531	amino acid
CVS48_01770	COG0405	Gamma-glutamyltransferase
CVS48_01780	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_01790	COG0114	fumarate hydratase activity
CVS48_01795	COG0802	atpase or kinase
CVS48_01800	COG0860	N-Acetylmuramoyl-L-alanine amidase
CVS48_01805	COG0586	Pfam SNARE associated Golgi protein
CVS48_01810	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CVS48_01815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CVS48_01820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CVS48_01835	COG0617	tRNA 3'-terminal CCA addition
CVS48_01840	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CVS48_01845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVS48_01850	COG2301	Belongs to the HpcH HpaI aldolase family
CVS48_01860	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CVS48_01865	COG0583	DNA-binding transcription factor activity
CVS48_01870	COG1024	Enoyl-CoA hydratase
CVS48_01880	COG1960	acyl-CoA dehydrogenase activity
CVS48_01895	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_01910	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_01920	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_01925	COG2030	dehydratase
CVS48_01930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_01945	COG1024	Enoyl-CoA hydratase
CVS48_01950	COG0752	glycyl-tRNA synthetase alpha subunit
CVS48_01955	COG0751	glycine-tRNA ligase activity
CVS48_01960	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CVS48_01965	COG0204	Acyl-transferase
CVS48_01980	COG0242	peptide deformylase activity
CVS48_01990	COG0700	Nucleoside recognition
CVS48_01995	COG0469	pyruvate kinase activity
CVS48_02000	COG1929	Belongs to the glycerate kinase type-1 family
CVS48_02005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CVS48_02010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS48_02015	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CVS48_02025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CVS48_02035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS48_02050	COG2154	pterin-4-alpha-carbinolamine dehydratase
CVS48_02080	COG3501	Rhs element vgr protein
CVS48_02140	COG3501	Rhs element vgr protein
CVS48_02220	COG0330	HflC and HflK could
CVS48_02240	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_02245	COG1309	transcriptional regulator
CVS48_02255	COG2982	Protein involved in outer membrane biogenesis
CVS48_02260	COG1368	sulfuric ester hydrolase activity
CVS48_02265	COG2818	Glycosylase
CVS48_02280	COG0735	belongs to the Fur family
CVS48_02290	COG0583	DNA-binding transcription factor activity
CVS48_02295	COG0840	transmembrane signaling receptor activity
CVS48_02325	COG2011	ABC-type metal ion transport system permease component
CVS48_02330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CVS48_02335	COG1501	Belongs to the glycosyl hydrolase 31 family
CVS48_02340	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CVS48_02340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_02345	COG0483	inositol monophosphate 1-phosphatase activity
CVS48_02350	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_02355	COG1473	amidohydrolase
CVS48_02365	COG2855	membrane
CVS48_02370	COG1607	acyl-coa hydrolase
CVS48_02375	COG2239	Acts as a magnesium transporter
CVS48_02390	COG1522	sequence-specific DNA binding
CVS48_02395	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_02400	COG0028	Belongs to the TPP enzyme family
CVS48_02415	COG3415	Transposase
CVS48_02415	COG2801	Transposase and inactivated derivatives
CVS48_02425	COG0653	protein targeting
CVS48_02430	COG0739	heme binding
CVS48_02440	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CVS48_02445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CVS48_02455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CVS48_02460	COG1181	Belongs to the D-alanine--D-alanine ligase family
CVS48_02465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CVS48_02470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CVS48_02480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CVS48_02485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVS48_02490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CVS48_02500	COG3116	cell division
CVS48_02505	COG0275	rRNA processing
CVS48_02510	COG2001	Belongs to the MraZ family
CVS48_02525	COG0418	dihydroorotase activity
CVS48_02530	COG1473	amidohydrolase
CVS48_02575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVS48_02580	COG4654	Cytochrome c, class I
CVS48_02585	COG0129	dihydroxy-acid dehydratase activity
CVS48_02625	COG2084	Dehydrogenase
CVS48_02630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CVS48_02640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS48_02675	COG0824	Thioesterase
CVS48_02680	COG0811	peptide transport
CVS48_02685	COG0848	biopolymer transport protein
CVS48_02695	COG0823	Involved in the tonB-independent uptake of proteins
CVS48_02710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS48_02715	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CVS48_02730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CVS48_02745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_02750	COG0697	spore germination
CVS48_02775	COG0583	DNA-binding transcription factor activity
CVS48_02790	COG0463	Glycosyl transferase, family 2
CVS48_02800	COG0786	glutamate:sodium symporter activity
CVS48_02815	COG1671	Belongs to the UPF0178 family
CVS48_02825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CVS48_02830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS48_02840	COG0328	RNA-DNA hybrid ribonuclease activity
CVS48_02845	COG2226	methyltransferase
CVS48_02855	COG0741	lytic transglycosylase activity
CVS48_02855	COG1388	LysM domain
CVS48_02875	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_02900	COG3188	usher protein
CVS48_02910	COG2197	response regulator
CVS48_02935	COG2719	SpoVR family
CVS48_02940	COG2718	Belongs to the UPF0229 family
CVS48_02945	COG2766	serine protein kinase
CVS48_02950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVS48_02950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVS48_02965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CVS48_02970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CVS48_02975	COG1881	PFAM PEBP family protein
CVS48_02980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CVS48_02990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CVS48_02995	COG0316	Belongs to the HesB IscA family
CVS48_03005	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CVS48_03010	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CVS48_03015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CVS48_03020	COG0410	ABC transporter
CVS48_03030	COG4177	L-phenylalanine transmembrane transporter activity
CVS48_03035	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_03045	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CVS48_03050	COG0312	modulator of DNA gyrase
CVS48_03055	COG3028	Belongs to the UPF0307 family
CVS48_03070	COG1116	anion transmembrane transporter activity
CVS48_03075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_03080	COG1335	isochorismatase
CVS48_03085	COG0045	succinate-CoA ligase (ADP-forming) activity
CVS48_03085	COG1042	CoA-binding domain protein
CVS48_03085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS48_03090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS48_03095	COG2814	Major facilitator Superfamily
CVS48_03105	COG1522	sequence-specific DNA binding
CVS48_03135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVS48_03140	COG1696	Membrane protein involved in D-alanine export
CVS48_03165	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CVS48_03165	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CVS48_03175	COG2264	protein methyltransferase activity
CVS48_03180	COG0439	Biotin carboxylase
CVS48_03185	COG0511	ligase activity, forming carbon-carbon bonds
CVS48_03190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CVS48_03195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS48_03200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CVS48_03205	COG3150	esterase
CVS48_03210	COG0557	exoribonuclease II activity
CVS48_03220	COG0642	Histidine kinase
CVS48_03225	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS48_03230	COG1175	transmembrane transport
CVS48_03245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CVS48_03250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVS48_03260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CVS48_03265	COG3328	transposase activity
CVS48_03270	COG1126	abc transporter atp-binding protein
CVS48_03275	COG0765	amino acid transport
CVS48_03285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_03295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS48_03310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CVS48_03325	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CVS48_03330	COG1678	Uncharacterized ACR, COG1678
CVS48_03350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CVS48_03355	COG0741	lytic transglycosylase activity
CVS48_03365	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_03370	COG1335	isochorismatase
CVS48_03375	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CVS48_03380	COG4638	Rieske (2fe-2S)
CVS48_03395	COG2207	Transcriptional regulator
CVS48_03420	COG1024	Enoyl-CoA hydratase
CVS48_03425	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_03460	COG0410	ABC transporter
CVS48_03465	COG0411	ABC transporter
CVS48_03475	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_03495	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CVS48_03505	COG0494	nUDIX hydrolase
CVS48_03520	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CVS48_03525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_03540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS48_03555	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CVS48_03560	COG0237	dephospho-CoA kinase activity
CVS48_03565	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CVS48_03580	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CVS48_03585	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CVS48_03595	COG0477	Major facilitator Superfamily
CVS48_03600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CVS48_03605	COG3328	transposase activity
CVS48_03615	COG1194	a g-specific adenine glycosylase
CVS48_03625	COG2226	methyltransferase
CVS48_03630	COG0246	Mannitol dehydrogenase
CVS48_03635	COG4948	Mandelate Racemase Muconate Lactonizing
CVS48_03640	COG1126	abc transporter atp-binding protein
CVS48_03645	COG0765	amino acid transport
CVS48_03650	COG0765	amino acid transport
CVS48_03655	COG1063	alcohol dehydrogenase
CVS48_03665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CVS48_03670	COG2186	Transcriptional regulator
CVS48_03685	COG4771	TonB-dependent receptor
CVS48_03690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVS48_03695	COG2022	thiamine diphosphate biosynthetic process
CVS48_03700	COG0351	phosphomethylpyrimidine kinase
CVS48_03705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CVS48_03715	COG2801	Transposase and inactivated derivatives
CVS48_03715	COG3415	Transposase
CVS48_03720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CVS48_03730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CVS48_03745	COG2226	methyltransferase
CVS48_03750	COG0745	RESPONSE REGULATOR receiver
CVS48_03765	COG0642	Histidine kinase
CVS48_03770	COG2132	Multicopper oxidase
CVS48_03785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS48_03790	COG2801	Transposase and inactivated derivatives
CVS48_03790	COG3415	Transposase
CVS48_03795	COG0583	DNA-binding transcription factor activity
CVS48_03805	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CVS48_03810	COG1984	allophanate hydrolase subunit 2
CVS48_03815	COG1802	Transcriptional regulator
CVS48_03820	COG2860	membrane
CVS48_03830	COG2223	nitrite transmembrane transporter activity
CVS48_03835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CVS48_03835	COG2813	Specifically methylates the guanine in position
CVS48_03840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CVS48_03845	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CVS48_03855	COG2197	response regulator
CVS48_03870	COG2918	glutathione biosynthetic process
CVS48_03890	COG0583	DNA-binding transcription factor activity
CVS48_03900	COG1802	Transcriptional regulator
CVS48_03920	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_03930	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVS48_03955	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_03970	COG1309	transcriptional regulator
CVS48_03980	COG1024	Enoyl-CoA hydratase
CVS48_03985	COG1024	Enoyl-CoA hydratase
CVS48_03990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CVS48_04000	COG0747	negative chemotaxis
CVS48_04005	COG2988	succinylglutamate desuccinylase activity
CVS48_04010	COG0601	transmembrane transport
CVS48_04020	COG0444	Belongs to the ABC transporter superfamily
CVS48_04025	COG4608	Belongs to the ABC transporter superfamily
CVS48_04035	COG2195	Cleaves the N-terminal amino acid of tripeptides
CVS48_04040	COG2171	N-acyltransferase activity
CVS48_04050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CVS48_04065	COG0210	DNA helicase
CVS48_04070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CVS48_04075	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CVS48_04085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CVS48_04090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CVS48_04095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CVS48_04100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CVS48_04105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CVS48_04110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CVS48_04120	COG0356	it plays a direct role in the translocation of protons across the membrane
CVS48_04135	COG1024	Enoyl-CoA hydratase
CVS48_04140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVS48_04150	COG3188	usher protein
CVS48_04155	COG3121	Chaperone
CVS48_04160	COG3539	Fimbrial protein
CVS48_04170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CVS48_04195	COG0037	tRNA processing
CVS48_04200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS48_04205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVS48_04210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS48_04215	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CVS48_04220	COG2967	ApaG domain
CVS48_04230	COG0546	phosphoglycolate phosphatase activity
CVS48_04240	COG0512	Glutamine amidotransferase of anthranilate synthase
CVS48_04245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CVS48_04250	COG0134	indole-3-glycerol-phosphate synthase activity
CVS48_04255	COG3284	Transcriptional regulator
CVS48_04260	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_04280	COG0583	DNA-binding transcription factor activity
CVS48_04290	COG1305	Transglutaminase-like
CVS48_04300	COG3276	selenocysteine insertion sequence binding
CVS48_04305	COG1921	L-seryl-tRNASec selenium transferase activity
CVS48_04310	COG3058	Necessary for formate dehydrogenase activity
CVS48_04315	COG2864	formate dehydrogenase
CVS48_04320	COG0437	4 iron, 4 sulfur cluster binding
CVS48_04325	COG3383	formate dehydrogenase (NAD+) activity
CVS48_04325	COG0243	molybdopterin cofactor binding
CVS48_04330	COG0243	molybdopterin cofactor binding
CVS48_04330	COG3383	formate dehydrogenase (NAD+) activity
CVS48_04340	COG1607	acyl-coa hydrolase
CVS48_04365	COG3064	Membrane
CVS48_04385	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_04390	COG3069	C4-dicarboxylate transmembrane transporter activity
CVS48_04400	COG1802	Transcriptional regulator
CVS48_04440	COG2814	Major facilitator Superfamily
CVS48_04445	COG0840	transmembrane signaling receptor activity
CVS48_04450	COG1228	amidohydrolase
CVS48_04465	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CVS48_04470	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CVS48_04480	COG2188	Transcriptional regulator
CVS48_04500	COG0297	glycogen (starch) synthase activity
CVS48_04515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVS48_04525	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CVS48_04530	COG5001	Diguanylate cyclase
CVS48_04540	COG2423	ornithine cyclodeaminase activity
CVS48_04545	COG1522	sequence-specific DNA binding
CVS48_04580	COG4944	Protein of unknown function (DUF1109)
CVS48_04585	COG1595	DNA-templated transcription, initiation
CVS48_04590	COG3300	MHYT domain
CVS48_04590	COG5001	Diguanylate cyclase
CVS48_04595	COG0583	DNA-binding transcription factor activity
CVS48_04600	COG2814	Major facilitator Superfamily
CVS48_04610	COG0583	DNA-binding transcription factor activity
CVS48_04615	COG0656	L-ascorbic acid biosynthetic process
CVS48_04620	COG0583	DNA-binding transcription factor activity
CVS48_04625	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_04630	COG0154	amidase activity
CVS48_04635	COG0243	molybdopterin cofactor binding
CVS48_04655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CVS48_04665	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVS48_04690	COG0583	DNA-binding transcription factor activity
CVS48_04695	COG3866	Pectate lyase
CVS48_04725	COG0438	transferase activity, transferring glycosyl groups
CVS48_04730	COG0457	Tetratricopeptide repeat
CVS48_04760	COG0251	oxidation-reduction process
CVS48_04765	COG0583	DNA-binding transcription factor activity
CVS48_04795	COG0410	ABC transporter
CVS48_04820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_04820	COG2198	Histidine kinase
CVS48_04820	COG0784	Response regulator, receiver
CVS48_04820	COG2205	protein histidine kinase activity
CVS48_04825	COG3437	response regulator, receiver
CVS48_04840	COG1074	ATP-dependent DNA helicase activity
CVS48_04870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CVS48_04900	COG2814	Major facilitator Superfamily
CVS48_04905	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CVS48_04925	COG1999	signal sequence binding
CVS48_04930	COG0109	protoheme IX farnesyltransferase activity
CVS48_04935	COG1612	heme a metabolic process
CVS48_04970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVS48_04990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CVS48_04995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CVS48_05015	COG0067	glutamate synthase
CVS48_05015	COG0069	glutamate synthase activity
CVS48_05015	COG0070	glutamate synthase
CVS48_05030	COG0583	DNA-binding transcription factor activity
CVS48_05035	COG0477	Major facilitator Superfamily
CVS48_05045	COG2070	2-Nitropropane dioxygenase
CVS48_05050	COG1127	ABC transporter
CVS48_05055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CVS48_05060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CVS48_05065	COG2853	Lipoprotein
CVS48_05075	COG1131	(ABC) transporter
CVS48_05080	COG0842	Transport permease protein
CVS48_05085	COG0271	Belongs to the BolA IbaG family
CVS48_05090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CVS48_05095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CVS48_05100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CVS48_05105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVS48_05110	COG0131	Imidazoleglycerol-phosphate dehydratase
CVS48_05115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CVS48_05120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CVS48_05125	COG0107	imidazoleglycerol-phosphate synthase activity
CVS48_05130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CVS48_05135	COG0140	phosphoribosyl-ATP diphosphatase activity
CVS48_05140	COG0537	adenosine 5'-monophosphoramidase activity
CVS48_05145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVS48_05150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVS48_05170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CVS48_05175	COG1970	mechanosensitive ion channel activity
CVS48_05180	COG0723	plastoquinol--plastocyanin reductase activity
CVS48_05185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CVS48_05190	COG2857	Cytochrome c1
CVS48_05195	COG0625	glutathione transferase activity
CVS48_05200	COG2969	positive regulation of protein catabolic process
CVS48_05205	COG3718	enzyme involved in inositol metabolism
CVS48_05215	COG3962	Belongs to the TPP enzyme family
CVS48_05230	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVS48_05240	COG1737	Transcriptional regulator
CVS48_05245	COG0673	inositol 2-dehydrogenase activity
CVS48_05250	COG0673	inositol 2-dehydrogenase activity
CVS48_05280	COG0154	amidase activity
CVS48_05285	COG1414	Transcriptional regulator
CVS48_05295	COG0583	DNA-binding transcription factor activity
CVS48_05310	COG0697	spore germination
CVS48_05315	COG3708	Transcriptional regulator
CVS48_05315	COG2207	Transcriptional regulator
CVS48_05325	COG1160	GTP binding
CVS48_05330	COG0747	negative chemotaxis
CVS48_05335	COG0601	transmembrane transport
CVS48_05340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_05355	COG5339	Protein conserved in bacteria
CVS48_05360	COG0513	Belongs to the DEAD box helicase family
CVS48_05365	COG1280	lysine exporter protein (LysE YggA)
CVS48_05370	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CVS48_05390	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CVS48_05400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_05410	COG1609	Transcriptional regulator
CVS48_05415	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CVS48_05420	COG3842	ATPase activity
CVS48_05425	COG1653	transport
CVS48_05430	COG1175	transmembrane transport
CVS48_05435	COG0395	ABC-type sugar transport system, permease component
CVS48_05450	COG0018	arginyl-trna synthetase
CVS48_05460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVS48_05480	COG0778	Nitroreductase
CVS48_05485	COG1280	lysine exporter protein (LysE YggA)
CVS48_05505	COG1960	acyl-CoA dehydrogenase activity
CVS48_05510	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CVS48_05515	COG0183	Belongs to the thiolase family
CVS48_05520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CVS48_05535	COG0693	protein deglycase activity
CVS48_05560	COG3852	Histidine kinase
CVS48_05565	COG2204	response regulator
CVS48_05585	COG0346	lactoylglutathione lyase activity
CVS48_05595	COG0668	transmembrane transport
CVS48_05615	COG0583	DNA-binding transcription factor activity
CVS48_05630	COG0300	oxidoreductase activity
CVS48_05635	COG2207	Transcriptional regulator
CVS48_05660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVS48_05670	COG0477	Major facilitator Superfamily
CVS48_05675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_05680	COG0765	amino acid transport
CVS48_05685	COG0765	amino acid transport
CVS48_05710	COG2922	Belongs to the Smg family
CVS48_05715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS48_05725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CVS48_05725	COG0551	DNA topoisomerase type I activity
CVS48_05735	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CVS48_05740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_05745	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_05750	COG0028	Belongs to the TPP enzyme family
CVS48_05755	COG1522	sequence-specific DNA binding
CVS48_05760	COG3781	membrane
CVS48_05770	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CVS48_05790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CVS48_05800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CVS48_05830	COG0402	S-adenosylhomocysteine deaminase activity
CVS48_05860	COG1177	transmembrane transport
CVS48_05865	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS48_05870	COG3842	ATPase activity
CVS48_05880	COG2188	Transcriptional regulator
CVS48_05895	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_05935	COG1177	transmembrane transport
CVS48_05940	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS48_05945	COG3842	ATPase activity
CVS48_05955	COG1304	FMN binding
CVS48_05965	COG1254	Belongs to the acylphosphatase family
CVS48_05980	COG1126	abc transporter atp-binding protein
CVS48_05985	COG0765	amino acid transport
CVS48_05990	COG0765	amino acid transport
CVS48_06000	COG0583	DNA-binding transcription factor activity
CVS48_06030	COG0592	DNA-directed DNA polymerase activity
CVS48_06040	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CVS48_06045	COG0594	ribonuclease P activity
CVS48_06050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CVS48_06060	COG0753	catalase activity
CVS48_06065	COG1473	amidohydrolase
CVS48_06070	COG4608	Belongs to the ABC transporter superfamily
CVS48_06075	COG0444	Belongs to the ABC transporter superfamily
CVS48_06080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_06085	COG0601	transmembrane transport
CVS48_06095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CVS48_06100	COG0454	-acetyltransferase
CVS48_06100	COG0456	acetyltransferase
CVS48_06105	COG0038	chloride channel
CVS48_06115	COG5002	protein histidine kinase activity
CVS48_06115	COG3850	Histidine kinase
CVS48_06135	COG0436	Aminotransferase
CVS48_06140	COG3180	Ammonia monooxygenase
CVS48_06145	COG1278	Cold shock
CVS48_06150	COG0445	tRNA wobble uridine modification
CVS48_06155	COG0357	Ribosomal RNA small subunit methyltransferase G
CVS48_06160	COG1192	Involved in chromosome partitioning
CVS48_06170	COG1475	DNA binding
CVS48_06175	COG0252	asparaginase activity
CVS48_06180	COG0583	DNA-binding transcription factor activity
CVS48_06235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVS48_06255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CVS48_06260	COG0081	regulation of translation
CVS48_06265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CVS48_06270	COG0222	ribosome binding
CVS48_06275	COG0085	RNA polymerase activity
CVS48_06280	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CVS48_06315	COG0745	RESPONSE REGULATOR receiver
CVS48_06320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CVS48_06325	COG0049	tRNA binding
CVS48_06330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CVS48_06335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVS48_06340	COG0051	transcription antitermination factor activity, RNA binding
CVS48_06345	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CVS48_06350	COG1414	Transcriptional regulator
CVS48_06360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_06375	COG1116	anion transmembrane transporter activity
CVS48_06380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_06385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CVS48_06390	COG0088	Forms part of the polypeptide exit tunnel
CVS48_06395	COG0089	rRNA binding
CVS48_06400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CVS48_06405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CVS48_06410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CVS48_06415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CVS48_06420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CVS48_06425	COG0255	Belongs to the universal ribosomal protein uL29 family
CVS48_06430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CVS48_06450	COG4177	L-phenylalanine transmembrane transporter activity
CVS48_06455	COG0410	ABC transporter
CVS48_06460	COG0411	ABC transporter
CVS48_06475	COG2207	Transcriptional regulator
CVS48_06490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CVS48_06495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CVS48_06500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CVS48_06505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CVS48_06510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CVS48_06515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CVS48_06520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CVS48_06525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CVS48_06530	COG1841	ribosomal large subunit assembly
CVS48_06535	COG0200	Binds to the 23S rRNA
CVS48_06540	COG0201	protein transport
CVS48_06545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CVS48_06550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CVS48_06555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CVS48_06560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CVS48_06565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CVS48_06570	COG0202	RNA polymerase activity
CVS48_06575	COG0203	ribosomal protein L17
CVS48_06585	COG1324	tolerance protein
CVS48_06590	COG4232	protein-disulfide reductase activity
CVS48_06605	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CVS48_06615	COG1333	cytochrome c biogenesis protein
CVS48_06620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVS48_06645	COG3501	Rhs element vgr protein
CVS48_06740	COG0019	diaminopimelate decarboxylase activity
CVS48_06750	COG1965	Belongs to the frataxin family
CVS48_06760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CVS48_06765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CVS48_06770	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CVS48_06785	COG2814	Major facilitator Superfamily
CVS48_06790	COG0629	single-stranded DNA binding
CVS48_06795	COG3210	domain, Protein
CVS48_06815	COG0583	DNA-binding transcription factor activity
CVS48_06820	COG4948	Mandelate Racemase Muconate Lactonizing
CVS48_06825	COG4774	siderophore transport
CVS48_06830	COG2207	Transcriptional regulator
CVS48_06835	COG2226	methyltransferase
CVS48_06865	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CVS48_06870	COG2186	Transcriptional regulator
CVS48_06895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_06900	COG1956	GAF domain-containing protein
CVS48_06905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_06920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVS48_06945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CVS48_06950	COG3568	Endonuclease Exonuclease Phosphatase
CVS48_06955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS48_06965	COG0477	Major facilitator Superfamily
CVS48_06970	COG0756	dUTP diphosphatase activity
CVS48_06995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVS48_07030	COG1134	teichoic acid transport
CVS48_07045	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CVS48_07055	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CVS48_07065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CVS48_07075	COG2089	acid synthase
CVS48_07080	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CVS48_07085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CVS48_07090	COG1088	dTDP-glucose 4,6-dehydratase activity
CVS48_07110	COG0438	transferase activity, transferring glycosyl groups
CVS48_07115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CVS48_07120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CVS48_07140	COG0673	inositol 2-dehydrogenase activity
CVS48_07145	COG0859	PFAM glycosyl transferase family 9
CVS48_07160	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CVS48_07170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CVS48_07195	COG1686	Belongs to the peptidase S11 family
CVS48_07205	COG2921	Belongs to the UPF0250 family
CVS48_07210	COG0321	lipoyl(octanoyl) transferase activity
CVS48_07220	COG1609	Transcriptional regulator
CVS48_07225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CVS48_07230	COG2096	Adenosyltransferase
CVS48_07240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CVS48_07245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CVS48_07250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CVS48_07255	COG0523	cobalamin synthesis protein
CVS48_07260	COG0735	belongs to the Fur family
CVS48_07285	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CVS48_07290	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CVS48_07300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CVS48_07305	COG1560	Kdo2-lipid A biosynthetic process
CVS48_07315	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CVS48_07320	COG0154	amidase activity
CVS48_07325	COG0477	Major facilitator Superfamily
CVS48_07360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CVS48_07375	COG0583	DNA-binding transcription factor activity
CVS48_07380	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_07390	COG0066	3-isopropylmalate dehydratase activity
CVS48_07395	COG0596	Alpha beta hydrolase
CVS48_07405	COG0438	transferase activity, transferring glycosyl groups
CVS48_07410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CVS48_07415	COG1950	PFAM Membrane protein of
CVS48_07420	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CVS48_07435	COG1305	Transglutaminase-like
CVS48_07445	COG2308	Evidence 4 Homologs of previously reported genes of
CVS48_07470	COG0513	Belongs to the DEAD box helicase family
CVS48_07475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CVS48_07480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CVS48_07515	COG0640	Transcriptional regulator
CVS48_07550	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_07570	COG1846	Transcriptional regulator
CVS48_07575	COG1764	response to oxidative stress
CVS48_07585	COG0583	DNA-binding transcription factor activity
CVS48_07595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CVS48_07600	COG0708	Exodeoxyribonuclease III
CVS48_07605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CVS48_07615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CVS48_07620	COG0154	amidase activity
CVS48_07625	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CVS48_07630	COG1077	Cell shape determining protein MreB Mrl
CVS48_07635	COG1792	Involved in formation and maintenance of cell shape
CVS48_07645	COG0768	penicillin binding
CVS48_07650	COG0772	Belongs to the SEDS family
CVS48_07655	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CVS48_07660	COG0471	metal ion transport
CVS48_07665	COG1309	transcriptional regulator
CVS48_07675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CVS48_07680	COG1464	Belongs to the NlpA lipoprotein family
CVS48_07685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS48_07690	COG2823	Periplasmic or secreted lipoprotein
CVS48_07695	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CVS48_07700	COG0792	nuclease activity
CVS48_07710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CVS48_07720	COG1660	Displays ATPase and GTPase activities
CVS48_07735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_07740	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CVS48_07750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CVS48_07755	COG1137	ATPase activity
CVS48_07770	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CVS48_07780	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CVS48_07790	COG1271	oxidase subunit
CVS48_07795	COG1294	oxidase, subunit
CVS48_07805	COG4988	ABC transporter
CVS48_07810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CVS48_07815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CVS48_07830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_07835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVS48_07840	COG1238	metal cluster binding
CVS48_07850	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_07855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CVS48_07860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_07865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_07880	COG0758	DNA mediated transformation
CVS48_07885	COG0242	peptide deformylase activity
CVS48_07890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CVS48_07905	COG0546	phosphoglycolate phosphatase activity
CVS48_07930	COG1280	lysine exporter protein (LysE YggA)
CVS48_07935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVS48_07935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS48_07945	COG5000	phosphorelay sensor kinase activity
CVS48_07950	COG2204	response regulator
CVS48_07955	COG0569	domain protein
CVS48_07960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CVS48_07965	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CVS48_07970	COG2226	methyltransferase
CVS48_07980	COG1040	competence protein
CVS48_07985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CVS48_07990	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_08000	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CVS48_08005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CVS48_08015	COG0588	phosphoglycerate mutase activity
CVS48_08020	COG4942	peptidase
CVS48_08025	COG0793	Belongs to the peptidase S41A family
CVS48_08030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CVS48_08040	COG2186	Transcriptional regulator
CVS48_08050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CVS48_08055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS48_08070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CVS48_08075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CVS48_08080	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CVS48_08085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CVS48_08090	COG1414	Transcriptional regulator
CVS48_08100	COG0142	geranyltranstransferase activity
CVS48_08110	COG0489	protein tyrosine kinase activity
CVS48_08180	COG4974	Belongs to the 'phage' integrase family
CVS48_08200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVS48_08240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_08275	COG0463	Glycosyl transferase, family 2
CVS48_08280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CVS48_08290	COG0439	Biotin carboxylase
CVS48_08330	COG3133	Outer membrane lipoprotein
CVS48_08375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CVS48_08400	COG2948	multi-organism process
CVS48_08435	COG3451	type IV secretory pathway VirB4
CVS48_08455	COG0741	lytic transglycosylase activity
CVS48_08530	COG3501	Rhs element vgr protein
CVS48_08580	COG0659	secondary active sulfate transmembrane transporter activity
CVS48_08585	COG3415	Transposase
CVS48_08585	COG2801	Transposase and inactivated derivatives
CVS48_08595	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CVS48_08615	COG1024	Enoyl-CoA hydratase
CVS48_08625	COG1309	transcriptional regulator
CVS48_08635	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_08645	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_08650	COG0183	Belongs to the thiolase family
CVS48_08730	COG2226	methyltransferase
CVS48_08730	COG1073	alpha beta
CVS48_08745	COG0411	ABC transporter
CVS48_08755	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_08760	COG0683	leucine binding
CVS48_08765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVS48_08770	COG2084	Dehydrogenase
CVS48_08790	COG0235	Class ii aldolase
CVS48_08795	COG2271	Major facilitator Superfamily
CVS48_08800	COG3622	Belongs to the hyi family
CVS48_08805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS48_08810	COG2084	Dehydrogenase
CVS48_08815	COG3395	kinase activity
CVS48_08825	COG2186	Transcriptional regulator
CVS48_08845	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CVS48_08850	COG3842	ATPase activity
CVS48_08855	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS48_08860	COG0402	S-adenosylhomocysteine deaminase activity
CVS48_08885	COG3077	Addiction module antitoxin, RelB DinJ family
CVS48_08900	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_08905	COG0022	dehydrogenase e1 component
CVS48_08920	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS48_08950	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_08965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_08970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_08975	COG3622	Belongs to the hyi family
CVS48_08985	COG5006	permease, DMT superfamily
CVS48_08995	COG1522	sequence-specific DNA binding
CVS48_09005	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CVS48_09015	COG0583	DNA-binding transcription factor activity
CVS48_09020	COG1473	amidohydrolase
CVS48_09025	COG3264	Mechanosensitive ion channel
CVS48_09025	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CVS48_09030	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_09040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_09045	COG1116	anion transmembrane transporter activity
CVS48_09075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CVS48_09080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CVS48_09085	COG2890	protein-(glutamine-N5) methyltransferase activity
CVS48_09090	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CVS48_09105	COG1464	Belongs to the NlpA lipoprotein family
CVS48_09110	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_09120	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_09145	COG0583	DNA-binding transcription factor activity
CVS48_09160	COG0625	glutathione transferase activity
CVS48_09165	COG0288	reversible hydration of carbon dioxide
CVS48_09185	COG0596	Alpha beta hydrolase
CVS48_09200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CVS48_09210	COG1414	Transcriptional regulator
CVS48_09215	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_09220	COG2031	fatty acid transporter
CVS48_09225	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_09230	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CVS48_09235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CVS48_09250	COG0583	DNA-binding transcription factor activity
CVS48_09255	COG0129	dihydroxy-acid dehydratase activity
CVS48_09260	COG0583	DNA-binding transcription factor activity
CVS48_09265	COG2801	Transposase and inactivated derivatives
CVS48_09265	COG3415	Transposase
CVS48_09270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS48_09275	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS48_09285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CVS48_09290	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_09295	COG0410	ABC transporter
CVS48_09300	COG0411	ABC transporter
CVS48_09310	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_09325	COG2186	Transcriptional regulator
CVS48_09335	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CVS48_09345	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CVS48_09350	COG2177	Part of the ABC transporter FtsEX involved in
CVS48_09355	COG2884	Cell division ATP-binding protein ftsE
CVS48_09360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_09365	COG4597	amino acid ABC transporter
CVS48_09370	COG0765	amino acid transport
CVS48_09375	COG1126	abc transporter atp-binding protein
CVS48_09390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS48_09395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS48_09405	COG0077	Prephenate dehydratase
CVS48_09405	COG1605	Chorismate mutase
CVS48_09410	COG0625	glutathione transferase activity
CVS48_09455	COG0583	DNA-binding transcription factor activity
CVS48_09460	COG0628	permease
CVS48_09475	COG3328	transposase activity
CVS48_09480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_09485	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS48_09490	COG3842	ATPase activity
CVS48_09500	COG0277	FAD linked oxidase domain protein
CVS48_09510	COG0477	Major facilitator Superfamily
CVS48_09520	COG1695	Transcriptional regulator
CVS48_09530	COG0583	DNA-binding transcription factor activity
CVS48_09580	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_09590	COG3246	L-lysine catabolic process to acetate
CVS48_09595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS48_09600	COG0210	DNA helicase
CVS48_09605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_09615	COG0583	DNA-binding transcription factor activity
CVS48_09620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CVS48_09625	COG0477	Major facilitator Superfamily
CVS48_09635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CVS48_09635	COG2010	Cytochrome c
CVS48_09640	COG1335	isochorismatase
CVS48_09645	COG2309	aminopeptidase activity
CVS48_09650	COG0596	Alpha beta hydrolase
CVS48_09655	COG3473	Maleate cis-trans isomerase
CVS48_09665	COG2080	2 iron, 2 sulfur cluster binding
CVS48_09670	COG2010	Cytochrome c
CVS48_09670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CVS48_09675	COG0477	Major facilitator Superfamily
CVS48_09680	COG1846	Transcriptional regulator
CVS48_09735	COG2233	PERMEase
CVS48_09740	COG0326	Molecular chaperone. Has ATPase activity
CVS48_09745	COG1396	sequence-specific DNA binding
CVS48_09760	COG0604	alcohol dehydrogenase
CVS48_09770	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_09790	COG2814	Major facilitator Superfamily
CVS48_09800	COG2271	Major facilitator Superfamily
CVS48_09805	COG4948	Mandelate Racemase Muconate Lactonizing
CVS48_09810	COG0800	Aldolase
CVS48_09820	COG1414	Transcriptional regulator
CVS48_09825	COG0625	glutathione transferase activity
CVS48_09840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVS48_09845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CVS48_09850	COG1652	LysM domain
CVS48_09870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CVS48_09880	COG1802	Transcriptional regulator
CVS48_09885	COG3938	Belongs to the proline racemase family
CVS48_09895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_09900	COG3938	Belongs to the proline racemase family
CVS48_09905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_09915	COG0765	amino acid transport
CVS48_09920	COG1126	abc transporter atp-binding protein
CVS48_09940	COG3550	peptidyl-serine autophosphorylation
CVS48_09975	COG3246	L-lysine catabolic process to acetate
CVS48_09980	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_09985	COG2072	flavoprotein involved in K transport
CVS48_09990	COG3842	ATPase activity
CVS48_10005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CVS48_10010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS48_10015	COG1177	transmembrane transport
CVS48_10020	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS48_10040	COG0583	DNA-binding transcription factor activity
CVS48_10050	COG0165	Argininosuccinate lyase
CVS48_10065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_10070	COG3152	Membrane
CVS48_10080	COG2188	Transcriptional regulator
CVS48_10100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_10110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVS48_10140	COG2828	Protein conserved in bacteria
CVS48_10160	COG3284	Transcriptional regulator
CVS48_10170	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_10175	COG2267	carboxylic ester hydrolase activity
CVS48_10185	COG0583	DNA-binding transcription factor activity
CVS48_10190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVS48_10195	COG1131	(ABC) transporter
CVS48_10215	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_10225	COG0411	ABC transporter
CVS48_10230	COG0410	ABC transporter
CVS48_10285	COG3328	transposase activity
CVS48_10325	COG2205	protein histidine kinase activity
CVS48_10330	COG0745	RESPONSE REGULATOR receiver
CVS48_10370	COG0625	glutathione transferase activity
CVS48_10380	COG3976	FMN-binding domain protein
CVS48_10380	COG1053	succinate dehydrogenase
CVS48_10380	COG0431	NADPH-dependent FMN reductase
CVS48_10400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_10410	COG1294	oxidase, subunit
CVS48_10415	COG1271	oxidase subunit
CVS48_10425	COG0410	ABC transporter
CVS48_10440	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_10450	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_10460	COG2200	EAL domain
CVS48_10465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CVS48_10470	COG0745	RESPONSE REGULATOR receiver
CVS48_10510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS48_10510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS48_10520	COG0489	protein tyrosine kinase activity
CVS48_10535	COG0717	Belongs to the dCTP deaminase family
CVS48_10545	COG2203	Gaf domain
CVS48_10545	COG5001	Diguanylate cyclase
CVS48_10545	COG3706	GGDEF domain
CVS48_10545	COG4251	negative regulation of phosphorylation
CVS48_10560	COG1982	Orn Lys Arg decarboxylase major
CVS48_10565	COG2081	HI0933 family
CVS48_10580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CVS48_10585	COG0509	glycine decarboxylation via glycine cleavage system
CVS48_10590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVS48_10590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVS48_10595	COG5339	Protein conserved in bacteria
CVS48_10605	COG0154	amidase activity
CVS48_10610	COG4172	Belongs to the ABC transporter superfamily
CVS48_10615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_10620	COG0601	transmembrane transport
CVS48_10645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_10660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CVS48_10665	COG1765	OsmC-like protein
CVS48_10670	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CVS48_10675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVS48_10680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CVS48_10705	COG0438	transferase activity, transferring glycosyl groups
CVS48_10710	COG0438	transferase activity, transferring glycosyl groups
CVS48_10715	COG0438	transferase activity, transferring glycosyl groups
CVS48_10720	COG0166	Belongs to the GPI family
CVS48_10735	COG0277	FAD linked oxidase domain protein
CVS48_10740	COG0745	RESPONSE REGULATOR receiver
CVS48_10745	COG2205	protein histidine kinase activity
CVS48_10755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_10765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_10775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS48_10780	COG2186	Transcriptional regulator
CVS48_10785	COG1368	sulfuric ester hydrolase activity
CVS48_10790	COG3415	Transposase
CVS48_10790	COG2801	Transposase and inactivated derivatives
CVS48_10800	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CVS48_10815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS48_10825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CVS48_10835	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CVS48_10840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CVS48_10845	COG1309	transcriptional regulator
CVS48_10850	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_10855	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CVS48_10860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CVS48_10870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CVS48_10875	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CVS48_10880	COG0193	aminoacyl-tRNA hydrolase activity
CVS48_10890	COG0012	GTP binding
CVS48_10895	COG4804	nuclease activity
CVS48_10905	COG2801	Transposase and inactivated derivatives
CVS48_10910	COG2814	Major facilitator Superfamily
CVS48_10925	COG0583	DNA-binding transcription factor activity
CVS48_10940	COG2814	Major facilitator Superfamily
CVS48_10955	COG3135	benzoate transporter
CVS48_10960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS48_10965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CVS48_10970	COG0742	ribosomal rna small subunit methyltransferase
CVS48_10995	COG3639	organic phosphonate transmembrane transporter activity
CVS48_11000	COG3639	organic phosphonate transmembrane transporter activity
CVS48_11005	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CVS48_11030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CVS48_11035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS48_11050	COG1546	Belongs to the CinA family
CVS48_11055	COG0284	orotidine-5'-phosphate decarboxylase activity
CVS48_11060	COG1252	NADH dehydrogenase
CVS48_11065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CVS48_11075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_11085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_11090	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_11095	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVS48_11100	COG2721	sulfolactate sulfo-lyase activity
CVS48_11105	COG0246	Mannitol dehydrogenase
CVS48_11115	COG0410	ABC transporter
CVS48_11120	COG1137	ATPase activity
CVS48_11130	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_11145	COG1917	Cupin 2, conserved barrel domain protein
CVS48_11160	COG0459	protein refolding
CVS48_11165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CVS48_11170	COG1024	Enoyl-CoA hydratase
CVS48_11175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_11185	COG1960	acyl-CoA dehydrogenase activity
CVS48_11190	COG0045	succinate-CoA ligase (ADP-forming) activity
CVS48_11190	COG1042	CoA-binding domain protein
CVS48_11190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS48_11200	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_11210	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_11215	COG2030	dehydratase
CVS48_11225	COG1960	acyl-CoA dehydrogenase activity
CVS48_11265	COG0583	DNA-binding transcription factor activity
CVS48_11275	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_11295	COG5001	Diguanylate cyclase
CVS48_11295	COG4251	negative regulation of phosphorylation
CVS48_11295	COG3706	GGDEF domain
CVS48_11295	COG2203	Gaf domain
CVS48_11305	COG0745	RESPONSE REGULATOR receiver
CVS48_11370	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_11375	COG1024	Enoyl-CoA hydratase
CVS48_11400	COG0745	RESPONSE REGULATOR receiver
CVS48_11405	COG2205	protein histidine kinase activity
CVS48_11420	COG0438	transferase activity, transferring glycosyl groups
CVS48_11445	COG2207	Transcriptional regulator
CVS48_11445	COG4753	response regulator
CVS48_11470	COG0477	Major facilitator Superfamily
CVS48_11480	COG0235	Class ii aldolase
CVS48_11500	COG0745	RESPONSE REGULATOR receiver
CVS48_11505	COG0784	Response regulator, receiver
CVS48_11505	COG2198	Histidine kinase
CVS48_11505	COG2205	protein histidine kinase activity
CVS48_11505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_11515	COG0277	FAD linked oxidase domain protein
CVS48_11530	COG0583	DNA-binding transcription factor activity
CVS48_11545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS48_11580	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_11590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS48_11595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS48_11600	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_11615	COG1414	Transcriptional regulator
CVS48_11645	COG1414	Transcriptional regulator
CVS48_11665	COG0583	DNA-binding transcription factor activity
CVS48_11690	COG1595	DNA-templated transcription, initiation
CVS48_11695	COG3712	iron ion homeostasis
CVS48_11735	COG1764	response to oxidative stress
CVS48_11740	COG0583	DNA-binding transcription factor activity
CVS48_11750	COG1595	DNA-templated transcription, initiation
CVS48_11765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVS48_11770	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_11780	COG0387	Pfam Sodium calcium exchanger
CVS48_11795	COG3135	benzoate transporter
CVS48_11805	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CVS48_11805	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CVS48_11825	COG1280	lysine exporter protein (LysE YggA)
CVS48_11835	COG3387	PFAM Glycoside hydrolase 15-related
CVS48_11840	COG3706	GGDEF domain
CVS48_11845	COG0745	RESPONSE REGULATOR receiver
CVS48_11860	COG3119	arylsulfatase activity
CVS48_11890	COG2353	YceI-like domain
CVS48_11910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS48_11930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS48_11945	COG0642	Histidine kinase
CVS48_11950	COG0745	RESPONSE REGULATOR receiver
CVS48_11960	COG2837	iron assimilation
CVS48_11990	COG0667	Aldo Keto reductase
CVS48_12005	COG0519	Catalyzes the synthesis of GMP from XMP
CVS48_12030	COG2197	response regulator
CVS48_12035	COG2205	protein histidine kinase activity
CVS48_12035	COG0784	Response regulator, receiver
CVS48_12040	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CVS48_12045	COG2205	protein histidine kinase activity
CVS48_12045	COG0784	Response regulator, receiver
CVS48_12070	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_12080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CVS48_12090	COG3346	SURF1 family
CVS48_12095	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CVS48_12100	COG1845	cytochrome c oxidase, subunit III
CVS48_12105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVS48_12110	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CVS48_12115	COG0477	Major facilitator Superfamily
CVS48_12150	COG0583	DNA-binding transcription factor activity
CVS48_12155	COG0861	Integral membrane protein TerC family
CVS48_12160	COG4106	trans-aconitate 2-methyltransferase activity
CVS48_12165	COG2207	Transcriptional regulator
CVS48_12170	COG2807	transmembrane transport
CVS48_12185	COG0330	HflC and HflK could
CVS48_12205	COG4773	Receptor
CVS48_12220	COG3712	iron ion homeostasis
CVS48_12235	COG1595	DNA-templated transcription, initiation
CVS48_12240	COG3712	iron ion homeostasis
CVS48_12250	COG2706	6-phosphogluconolactonase activity
CVS48_12260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CVS48_12275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS48_12280	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_12285	COG1285	pathogenesis
CVS48_12290	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_12320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS48_12325	COG1396	sequence-specific DNA binding
CVS48_12345	COG0583	DNA-binding transcription factor activity
CVS48_12350	COG0300	oxidoreductase activity
CVS48_12360	COG0583	DNA-binding transcription factor activity
CVS48_12375	COG0697	spore germination
CVS48_12390	COG0281	malic enzyme
CVS48_12390	COG0280	phosphate acetyltransferase
CVS48_12395	COG0583	DNA-binding transcription factor activity
CVS48_12400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS48_12420	COG2900	Belongs to the SlyX family
CVS48_12425	COG4772	TonB-dependent receptor
CVS48_12440	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CVS48_12445	COG1845	cytochrome c oxidase, subunit III
CVS48_12450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVS48_12460	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CVS48_12475	COG1999	signal sequence binding
CVS48_12490	COG1126	abc transporter atp-binding protein
CVS48_12495	COG0765	amino acid transport
CVS48_12500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_12505	COG3191	aminopeptidase activity
CVS48_12510	COG1272	protein, Hemolysin III
CVS48_12525	COG1113	amino acid transport
CVS48_12550	COG1595	DNA-templated transcription, initiation
CVS48_12555	COG3712	iron ion homeostasis
CVS48_12565	COG3720	iron ion transport
CVS48_12570	COG4558	Periplasmic binding protein
CVS48_12575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS48_12580	COG1120	ATPase activity
CVS48_12585	COG1666	GTP binding
CVS48_12590	COG0583	DNA-binding transcription factor activity
CVS48_12595	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CVS48_12615	COG0671	phosphoesterase, PA-phosphatase related
CVS48_12635	COG0410	ABC transporter
CVS48_12640	COG0411	ABC transporter
CVS48_12675	COG3328	transposase activity
CVS48_12700	COG0583	DNA-binding transcription factor activity
CVS48_12705	COG2828	Protein conserved in bacteria
CVS48_12715	COG1943	Transposase
CVS48_12730	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_12755	COG0745	RESPONSE REGULATOR receiver
CVS48_12760	COG2205	protein histidine kinase activity
CVS48_12775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CVS48_12780	COG0583	DNA-binding transcription factor activity
CVS48_12815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CVS48_12820	COG3383	formate dehydrogenase (NAD+) activity
CVS48_12840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CVS48_12845	COG0746	molybdenum cofactor guanylyltransferase activity
CVS48_12850	COG0303	'Molybdopterin
CVS48_12855	COG0521	Mo-molybdopterin cofactor biosynthetic process
CVS48_12860	COG0314	molybdopterin synthase activity
CVS48_12870	COG0315	cyclic pyranopterin monophosphate synthase activity
CVS48_12880	COG0412	Dienelactone hydrolase
CVS48_12890	COG0678	peroxiredoxin activity
CVS48_12890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CVS48_12905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CVS48_12945	COG0667	Aldo Keto reductase
CVS48_12950	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CVS48_12955	COG4535	Mg2 and Co2 transporter CorC
CVS48_12960	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CVS48_12965	COG1702	phosphate starvation-inducible protein PhoH
CVS48_12970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVS48_12985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CVS48_12995	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS48_13000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS48_13005	COG1862	Preprotein translocase
CVS48_13010	COG0343	queuine tRNA-ribosyltransferase activity
CVS48_13015	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CVS48_13020	COG2027	D-alanyl-D-alanine carboxypeptidase
CVS48_13025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CVS48_13030	COG1648	precorrin-2 dehydrogenase activity
CVS48_13030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVS48_13040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS48_13045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_13050	COG1116	anion transmembrane transporter activity
CVS48_13055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVS48_13060	COG0243	molybdopterin cofactor binding
CVS48_13070	COG4575	ribosome binding
CVS48_13085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CVS48_13090	COG0741	lytic transglycosylase activity
CVS48_13095	COG0436	Aminotransferase
CVS48_13105	COG0280	phosphate acetyltransferase
CVS48_13105	COG0281	malic enzyme
CVS48_13115	COG2732	(Barnase) inhibitor
CVS48_13120	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CVS48_13130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CVS48_13135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CVS48_13140	COG0126	phosphoglycerate kinase activity
CVS48_13155	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CVS48_13160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CVS48_13175	COG0625	glutathione transferase activity
CVS48_13205	COG0306	phosphate transporter
CVS48_13215	COG0521	Mo-molybdopterin cofactor biosynthetic process
CVS48_13225	COG0739	heme binding
CVS48_13235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CVS48_13250	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CVS48_13255	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CVS48_13260	COG3639	organic phosphonate transmembrane transporter activity
CVS48_13280	COG0583	DNA-binding transcription factor activity
CVS48_13285	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CVS48_13290	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CVS48_13295	COG3454	Phosphonate metabolism
CVS48_13305	COG3624	Phosphonate C-P lyase system protein PhnG
CVS48_13315	COG3626	phosphonate metabolism
CVS48_13320	COG3627	carbon phosphorus lyase activity
CVS48_13325	COG4107	phosphonate C-P lyase system protein PhnK
CVS48_13330	COG4778	phosphonate C-P lyase system protein PhnL
CVS48_13335	COG3454	Phosphonate metabolism
CVS48_13350	COG1301	dicarboxylic acid transport
CVS48_13370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS48_13390	COG4172	Belongs to the ABC transporter superfamily
CVS48_13395	COG0154	amidase activity
CVS48_13410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CVS48_13415	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CVS48_13420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CVS48_13425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CVS48_13430	COG0009	L-threonylcarbamoyladenylate synthase
CVS48_13435	COG1414	Transcriptional regulator
CVS48_13440	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CVS48_13455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_13460	COG1414	Transcriptional regulator
CVS48_13470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_13480	COG1126	abc transporter atp-binding protein
CVS48_13485	COG0028	Belongs to the TPP enzyme family
CVS48_13495	COG0411	ABC transporter
CVS48_13525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CVS48_13550	COG1960	acyl-CoA dehydrogenase activity
CVS48_13555	COG0028	Belongs to the TPP enzyme family
CVS48_13560	COG0583	DNA-binding transcription factor activity
CVS48_13565	COG4974	Belongs to the 'phage' integrase family
CVS48_13590	COG0601	transmembrane transport
CVS48_13595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_13620	COG0583	DNA-binding transcription factor activity
CVS48_13625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_13635	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_13640	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CVS48_13655	COG1686	Belongs to the peptidase S11 family
CVS48_13680	COG2205	protein histidine kinase activity
CVS48_13695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVS48_13705	COG2271	Major facilitator Superfamily
CVS48_13715	COG1074	ATP-dependent DNA helicase activity
CVS48_13725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CVS48_13735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CVS48_13740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_13745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS48_13755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_13770	COG0745	RESPONSE REGULATOR receiver
CVS48_13785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CVS48_13790	COG0505	Belongs to the CarA family
CVS48_13795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CVS48_13815	COG3842	ATPase activity
CVS48_13825	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS48_13835	COG2233	PERMEase
CVS48_13840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVS48_13845	COG1534	Rna-binding protein
CVS48_13850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CVS48_13855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVS48_13865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CVS48_13900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CVS48_13910	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_13915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_13920	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_13930	COG4948	Mandelate Racemase Muconate Lactonizing
CVS48_13935	COG0028	Belongs to the TPP enzyme family
CVS48_13950	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_13955	COG2186	Transcriptional regulator
CVS48_13975	COG1090	epimerase
CVS48_13985	COG3685	Protein conserved in bacteria
CVS48_14010	COG0583	DNA-binding transcription factor activity
CVS48_14015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_14020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_14055	COG1335	isochorismatase
CVS48_14060	COG0583	DNA-binding transcription factor activity
CVS48_14065	COG2207	Transcriptional regulator
CVS48_14070	COG0667	Aldo Keto reductase
CVS48_14095	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CVS48_14110	COG0500	methyltransferase
CVS48_14115	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_14135	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_14145	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_14155	COG3246	L-lysine catabolic process to acetate
CVS48_14160	COG0371	Dehydrogenase
CVS48_14165	COG1802	Transcriptional regulator
CVS48_14170	COG3959	Transketolase, thiamine diphosphate binding domain
CVS48_14175	COG3958	Transketolase
CVS48_14180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CVS48_14190	COG3938	Belongs to the proline racemase family
CVS48_14195	COG1178	ABC-type Fe3 transport system permease component
CVS48_14200	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS48_14260	COG1511	domain protein
CVS48_14260	COG3264	Mechanosensitive ion channel
CVS48_14265	COG0583	DNA-binding transcription factor activity
CVS48_14270	COG0427	acetyl-CoA hydrolase
CVS48_14305	COG2204	response regulator
CVS48_14310	COG4191	Histidine kinase
CVS48_14315	COG1301	dicarboxylic acid transport
CVS48_14320	COG0424	maF-like protein
CVS48_14325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CVS48_14330	COG0799	negative regulation of ribosome biogenesis
CVS48_14335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CVS48_14340	COG0408	coproporphyrinogen oxidase activity
CVS48_14345	COG0151	Belongs to the GarS family
CVS48_14350	COG0217	transcriptional regulatory protein
CVS48_14355	COG0433	COG0433 Predicted ATPase
CVS48_14360	COG0473	3-isopropylmalate dehydrogenase activity
CVS48_14370	COG2814	Major facilitator Superfamily
CVS48_14375	COG1566	PFAM secretion protein HlyD family protein
CVS48_14415	COG3391	amine dehydrogenase activity
CVS48_14425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CVS48_14445	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CVS48_14450	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CVS48_14460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CVS48_14470	COG0187	DNA topoisomerase II activity
CVS48_14485	COG2311	Membrane
CVS48_14500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CVS48_14520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CVS48_14525	COG0662	Cupin 2, conserved barrel domain protein
CVS48_14530	COG5285	phytanoyl-CoA dioxygenase
CVS48_14535	COG0633	Ferredoxin
CVS48_14535	COG3217	Mosc domain protein beta barrel domain protein
CVS48_14540	COG2076	Multidrug Resistance protein
CVS48_14545	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CVS48_14555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_14610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CVS48_14615	COG0425	Belongs to the sulfur carrier protein TusA family
CVS48_14630	COG0228	four-way junction DNA binding
CVS48_14635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CVS48_14640	COG0336	Belongs to the RNA methyltransferase TrmD family
CVS48_14645	COG1396	sequence-specific DNA binding
CVS48_14650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_14655	COG0765	amino acid transport
CVS48_14660	COG1126	abc transporter atp-binding protein
CVS48_14665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_14675	COG0525	valine-tRNA ligase activity
CVS48_14680	COG0105	UTP biosynthetic process
CVS48_14685	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CVS48_14695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CVS48_14700	COG0124	histidyl-tRNA synthetase
CVS48_14705	COG2976	Protein conserved in bacteria
CVS48_14710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS48_14715	COG1160	GTP binding
CVS48_14720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVS48_14725	COG1923	regulation of RNA biosynthetic process
CVS48_14730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CVS48_14735	COG0330	HflC and HflK could
CVS48_14740	COG0330	HflC and HflK could
CVS48_14745	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CVS48_14750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CVS48_14755	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CVS48_14760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CVS48_14830	COG4964	Belongs to the GSP D family
CVS48_14860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CVS48_14870	COG1295	ribonuclease BN
CVS48_14880	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CVS48_14890	COG2205	protein histidine kinase activity
CVS48_14905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CVS48_14910	COG4783	chaperone-mediated protein folding
CVS48_14955	COG1538	Outer membrane efflux protein
CVS48_14960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CVS48_14965	COG0066	3-isopropylmalate dehydratase activity
CVS48_14970	COG0473	3-isopropylmalate dehydrogenase activity
CVS48_14975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CVS48_14985	COG0101	tRNA pseudouridine synthase activity
CVS48_14990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CVS48_14995	COG0135	phosphoribosylanthranilate isomerase activity
CVS48_15030	COG2832	Protein of unknown function (DUF454)
CVS48_15035	COG0129	dihydroxy-acid dehydratase activity
CVS48_15040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_15045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_15050	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CVS48_15055	COG1609	Transcriptional regulator
CVS48_15075	COG4172	Belongs to the ABC transporter superfamily
CVS48_15080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_15085	COG0601	transmembrane transport
CVS48_15110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CVS48_15115	COG2197	response regulator
CVS48_15120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CVS48_15125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CVS48_15130	COG0189	ligase activity
CVS48_15140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS48_15145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CVS48_15150	COG0004	ammonium transporteR
CVS48_15155	COG0347	Belongs to the P(II) protein family
CVS48_15160	COG2960	long-chain fatty acid transporting porin activity
CVS48_15170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CVS48_15175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CVS48_15180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CVS48_15185	COG0072	phenylalanine-tRNA ligase activity
CVS48_15185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS48_15190	COG0776	regulation of translation
CVS48_15215	COG2267	carboxylic ester hydrolase activity
CVS48_15225	COG0384	phenazine biosynthesis protein PhzF
CVS48_15230	COG0456	acetyltransferase
CVS48_15260	COG1522	sequence-specific DNA binding
CVS48_15300	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_15315	COG0583	DNA-binding transcription factor activity
CVS48_15330	COG5265	(ABC) transporter
CVS48_15335	COG0656	L-ascorbic acid biosynthetic process
CVS48_15350	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CVS48_15365	COG2223	nitrite transmembrane transporter activity
CVS48_15370	COG3300	MHYT domain
CVS48_15370	COG5001	Diguanylate cyclase
CVS48_15395	COG1610	YqeY-like protein
CVS48_15405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS48_15410	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_15420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS48_15460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVS48_15470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVS48_15475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVS48_15495	COG1017	nitric oxide dioxygenase activity
CVS48_15495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS48_15500	COG1959	2 iron, 2 sulfur cluster binding
CVS48_15505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_15510	COG0506	proline dehydrogenase activity
CVS48_15530	COG2814	Major facilitator Superfamily
CVS48_15540	COG0583	DNA-binding transcription factor activity
CVS48_15545	COG0625	glutathione transferase activity
CVS48_15560	COG2814	Major facilitator Superfamily
CVS48_15565	COG1960	acyl-CoA dehydrogenase activity
CVS48_15570	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_15605	COG1280	lysine exporter protein (LysE YggA)
CVS48_15625	COG0697	spore germination
CVS48_15630	COG0697	spore germination
CVS48_15645	COG1024	Enoyl-CoA hydratase
CVS48_15650	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_15660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVS48_15665	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CVS48_15670	COG4804	nuclease activity
CVS48_15675	COG2226	methyltransferase
CVS48_15705	COG4235	cytochrome complex assembly
CVS48_15715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS48_15745	COG4133	protoheme IX ABC transporter activity
CVS48_15750	COG3005	denitrification pathway
CVS48_15755	COG3043	anaerobic respiration
CVS48_15770	COG4459	periplasmic nitrate reductase
CVS48_15775	COG3246	L-lysine catabolic process to acetate
CVS48_15780	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_15785	COG0583	DNA-binding transcription factor activity
CVS48_15790	COG2336	PFAM SpoVT AbrB
CVS48_15805	COG0129	dihydroxy-acid dehydratase activity
CVS48_15810	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_15815	COG5001	Diguanylate cyclase
CVS48_15820	COG1024	Enoyl-CoA hydratase
CVS48_15830	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_15835	COG0583	DNA-binding transcription factor activity
CVS48_15840	COG2610	gluconate transmembrane transporter activity
CVS48_15855	COG2188	Transcriptional regulator
CVS48_15860	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_15885	COG4977	sequence-specific DNA binding
CVS48_15895	COG5265	(ABC) transporter
CVS48_15910	COG1132	(ABC) transporter
CVS48_15925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_15930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS48_15955	COG0583	DNA-binding transcription factor activity
CVS48_16005	COG1696	Membrane protein involved in D-alanine export
CVS48_16010	COG2186	Transcriptional regulator
CVS48_16015	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_16020	COG0307	riboflavin synthase, alpha
CVS48_16030	COG0235	Class ii aldolase
CVS48_16035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS48_16045	COG0789	Transcriptional regulator
CVS48_16055	COG1595	DNA-templated transcription, initiation
CVS48_16065	COG4774	siderophore transport
CVS48_16075	COG0022	dehydrogenase e1 component
CVS48_16105	COG3712	iron ion homeostasis
CVS48_16115	COG0165	Argininosuccinate lyase
CVS48_16120	COG0668	transmembrane transport
CVS48_16180	COG2165	general secretion pathway protein
CVS48_16190	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_16200	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_16205	COG0583	DNA-binding transcription factor activity
CVS48_16235	COG0583	DNA-binding transcription factor activity
CVS48_16245	COG0747	negative chemotaxis
CVS48_16250	COG0601	transmembrane transport
CVS48_16260	COG4172	Belongs to the ABC transporter superfamily
CVS48_16270	COG4681	YaeQ
CVS48_16280	COG4221	oxidoreductase activity
CVS48_16295	COG0642	Histidine kinase
CVS48_16300	COG0745	RESPONSE REGULATOR receiver
CVS48_16355	COG0625	glutathione transferase activity
CVS48_16360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVS48_16370	COG0165	Argininosuccinate lyase
CVS48_16380	COG1595	DNA-templated transcription, initiation
CVS48_16385	COG3712	iron ion homeostasis
CVS48_16395	COG1733	regulation of RNA biosynthetic process
CVS48_16400	COG0604	alcohol dehydrogenase
CVS48_16415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CVS48_16450	COG4268	DNA restriction-modification system
CVS48_16455	COG1401	restriction endodeoxyribonuclease activity
CVS48_16500	COG2188	Transcriptional regulator
CVS48_16530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CVS48_16535	COG0066	3-isopropylmalate dehydratase activity
CVS48_16550	COG1335	isochorismatase
CVS48_16575	COG3161	chorismate lyase activity
CVS48_16590	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_16600	COG0410	ABC transporter
CVS48_16620	COG1187	pseudouridine synthase activity
CVS48_16625	COG0583	DNA-binding transcription factor activity
CVS48_16640	COG1538	Outer membrane efflux protein
CVS48_16645	COG2261	transglycosylase associated protein
CVS48_16650	COG1999	signal sequence binding
CVS48_16660	COG0339	signal peptide processing
CVS48_16670	COG4566	intracellular signal transduction
CVS48_16680	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CVS48_16685	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS48_16690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS48_16715	COG2171	N-acyltransferase activity
CVS48_16735	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CVS48_16745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CVS48_16760	COG1191	sigma factor activity
CVS48_16785	COG2204	response regulator
CVS48_16795	COG0835	chemotaxis
CVS48_16800	COG0840	transmembrane signaling receptor activity
CVS48_16805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CVS48_16810	COG2201	protein-glutamate methylesterase activity
CVS48_16815	COG0745	RESPONSE REGULATOR receiver
CVS48_16820	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CVS48_16825	COG0840	transmembrane signaling receptor activity
CVS48_16835	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CVS48_16850	COG2747	anti-sigma28 factor FlgM
CVS48_16860	COG1815	bacterial-type flagellum-dependent cell motility
CVS48_16865	COG1558	bacterial-type flagellum-dependent cell motility
CVS48_16870	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CVS48_16875	COG1749	Flagellar hook protein flgE
CVS48_16880	COG4787	bacterial-type flagellum-dependent cell motility
CVS48_16885	COG4786	Flagellar basal body rod
CVS48_16890	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CVS48_16895	COG1706	bacterial-type flagellum-dependent cell motility
CVS48_16905	COG1256	bacterial-type flagellum assembly
CVS48_16915	COG0840	transmembrane signaling receptor activity
CVS48_16920	COG0840	transmembrane signaling receptor activity
CVS48_16935	COG0840	transmembrane signaling receptor activity
CVS48_16945	COG1987	bacterial-type flagellum assembly
CVS48_16970	COG1580	Controls the rotational direction of flagella during chemotaxis
CVS48_16990	COG1317	bacterial-type flagellum organization
CVS48_16995	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CVS48_17000	COG1766	The M ring may be actively involved in energy transduction
CVS48_17005	COG1677	Flagellar hook-basal body complex protein FliE
CVS48_17015	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CVS48_17035	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CVS48_17055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_17070	COG0285	dihydrofolate synthase activity
CVS48_17080	COG1286	toxin biosynthetic process
CVS48_17095	COG1451	nucleotide metabolic process
CVS48_17100	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CVS48_17110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CVS48_17115	COG0024	Methionine aminopeptidase
CVS48_17120	COG0052	Belongs to the universal ribosomal protein uS2 family
CVS48_17125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CVS48_17130	COG0528	UMP kinase activity
CVS48_17135	COG0233	cytoplasmic translational termination
CVS48_17140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CVS48_17145	COG0575	Belongs to the CDS family
CVS48_17150	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CVS48_17155	COG0750	zinc metalloprotease
CVS48_17160	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS48_17165	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CVS48_17170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS48_17175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVS48_17185	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS48_17190	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CVS48_17195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVS48_17210	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CVS48_17220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CVS48_17220	COG2169	Transcriptional regulator
CVS48_17225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVS48_17225	COG0519	Catalyzes the synthesis of GMP from XMP
CVS48_17240	COG3706	GGDEF domain
CVS48_17240	COG0745	RESPONSE REGULATOR receiver
CVS48_17245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CVS48_17250	COG2867	negative regulation of translational initiation
CVS48_17260	COG1960	acyl-CoA dehydrogenase activity
CVS48_17265	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CVS48_17290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CVS48_17295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CVS48_17300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CVS48_17305	COG0084	hydrolase, TatD family'
CVS48_17320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_17330	COG1126	abc transporter atp-binding protein
CVS48_17335	COG0010	Belongs to the arginase family
CVS48_17340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CVS48_17345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_17370	COG0625	glutathione transferase activity
CVS48_17380	COG1522	sequence-specific DNA binding
CVS48_17385	COG0386	Belongs to the glutathione peroxidase family
CVS48_17400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_17415	COG2259	Doxx family
CVS48_17440	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_17535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVS48_17540	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVS48_17550	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CVS48_17555	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CVS48_17560	COG0745	RESPONSE REGULATOR receiver
CVS48_17565	COG5002	protein histidine kinase activity
CVS48_17570	COG2070	2-Nitropropane dioxygenase
CVS48_17575	COG1414	Transcriptional regulator
CVS48_17580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_17615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_17625	COG1328	CTP reductase activity
CVS48_17690	COG1763	Mo-molybdopterin cofactor biosynthetic process
CVS48_17695	COG5295	Hep Hag repeat protein
CVS48_17705	COG0477	Major facilitator Superfamily
CVS48_17715	COG0583	DNA-binding transcription factor activity
CVS48_17740	COG0861	Integral membrane protein TerC family
CVS48_17745	COG0583	DNA-binding transcription factor activity
CVS48_17760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS48_17775	COG4948	Mandelate Racemase Muconate Lactonizing
CVS48_17795	COG3706	GGDEF domain
CVS48_17810	COG0583	DNA-binding transcription factor activity
CVS48_17815	COG3119	arylsulfatase activity
CVS48_17830	COG0251	oxidation-reduction process
CVS48_17845	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_17860	COG1304	FMN binding
CVS48_17895	COG0765	amino acid transport
CVS48_17920	COG0583	DNA-binding transcription factor activity
CVS48_17930	COG3706	GGDEF domain
CVS48_17945	COG4566	intracellular signal transduction
CVS48_17965	COG0583	DNA-binding transcription factor activity
CVS48_18005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS48_18015	COG0765	amino acid transport
CVS48_18020	COG1126	abc transporter atp-binding protein
CVS48_18025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CVS48_18035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVS48_18050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_18055	COG1126	abc transporter atp-binding protein
CVS48_18060	COG0765	amino acid transport
CVS48_18065	COG4597	amino acid ABC transporter
CVS48_18075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_18085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_18100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CVS48_18135	COG2721	sulfolactate sulfo-lyase activity
CVS48_18140	COG3386	PFAM SMP-30 Gluconolaconase
CVS48_18145	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_18175	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CVS48_18185	COG1335	isochorismatase
CVS48_18225	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_18235	COG0028	Belongs to the TPP enzyme family
CVS48_18255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_18270	COG0444	Belongs to the ABC transporter superfamily
CVS48_18275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_18285	COG0747	negative chemotaxis
CVS48_18290	COG2186	Transcriptional regulator
CVS48_18310	COG4172	Belongs to the ABC transporter superfamily
CVS48_18355	COG1408	metallophosphoesterase
CVS48_18360	COG4773	Receptor
CVS48_18375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CVS48_18390	COG0366	Alpha amylase catalytic
CVS48_18395	COG0366	Alpha amylase catalytic
CVS48_18400	COG0297	glycogen (starch) synthase activity
CVS48_18405	COG0028	Belongs to the TPP enzyme family
CVS48_18430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS48_18435	COG3568	Endonuclease Exonuclease Phosphatase
CVS48_18470	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CVS48_18475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CVS48_18480	COG4770	biotin carboxylase activity
CVS48_18490	COG1309	transcriptional regulator
CVS48_18505	COG0154	amidase activity
CVS48_18510	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_18515	COG3048	D-serine ammonia-lyase activity
CVS48_18520	COG0583	DNA-binding transcription factor activity
CVS48_18550	COG0589	response to stress
CVS48_18560	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CVS48_18565	COG0517	IMP dehydrogenase activity
CVS48_18580	COG2197	response regulator
CVS48_18585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CVS48_18595	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CVS48_18605	COG2072	flavoprotein involved in K transport
CVS48_18620	COG0431	NADPH-dependent FMN reductase
CVS48_18625	COG4172	Belongs to the ABC transporter superfamily
CVS48_18630	COG0444	Belongs to the ABC transporter superfamily
CVS48_18640	COG0601	transmembrane transport
CVS48_18645	COG0747	negative chemotaxis
CVS48_18665	COG3971	2-oxopent-4-enoate hydratase activity
CVS48_18680	COG2146	nitrite reductase [NAD(P)H] activity
CVS48_18705	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVS48_18730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVS48_18750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CVS48_18775	COG1201	RNA secondary structure unwinding
CVS48_18780	COG1793	dna ligase
CVS48_18785	COG1793	dna ligase
CVS48_18785	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CVS48_18795	COG0500	methyltransferase
CVS48_18815	COG0531	amino acid
CVS48_18820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CVS48_18825	COG1959	2 iron, 2 sulfur cluster binding
CVS48_18840	COG1619	proteins homologs of microcin C7 resistance protein MccF
CVS48_18845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CVS48_18865	COG3706	GGDEF domain
CVS48_18865	COG0745	RESPONSE REGULATOR receiver
CVS48_18870	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_18890	COG1846	Transcriptional regulator
CVS48_18895	COG2807	transmembrane transport
CVS48_18910	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_18910	COG1024	Enoyl-CoA hydratase
CVS48_18935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CVS48_18950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CVS48_18955	COG1253	flavin adenine dinucleotide binding
CVS48_18975	COG2863	cytochrome
CVS48_18990	COG2200	EAL domain
CVS48_18990	COG2199	diguanylate cyclase activity
CVS48_19005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS48_19040	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_19070	COG2204	response regulator
CVS48_19075	COG2204	response regulator
CVS48_19080	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CVS48_19110	COG2814	Major facilitator Superfamily
CVS48_19125	COG2203	Gaf domain
CVS48_19125	COG2199	diguanylate cyclase activity
CVS48_19125	COG2200	EAL domain
CVS48_19130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS48_19135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_19160	COG0488	(ABC) transporter
CVS48_19165	COG0688	phosphatidylethanolamine metabolic process
CVS48_19175	COG1408	metallophosphoesterase
CVS48_19190	COG1464	Belongs to the NlpA lipoprotein family
CVS48_19200	COG1414	Transcriptional regulator
CVS48_19225	COG2363	Small membrane protein
CVS48_19230	COG0697	spore germination
CVS48_19240	COG2133	pyrroloquinoline quinone binding
CVS48_19245	COG0625	glutathione transferase activity
CVS48_19260	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CVS48_19265	COG1794	racemase activity, acting on amino acids and derivatives
CVS48_19270	COG0410	ABC transporter
CVS48_19285	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_19295	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CVS48_19305	COG1653	transport
CVS48_19310	COG1175	transmembrane transport
CVS48_19315	COG0395	ABC-type sugar transport system, permease component
CVS48_19320	COG3842	ATPase activity
CVS48_19340	COG0156	8-amino-7-oxononanoate synthase activity
CVS48_19345	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CVS48_19345	COG0517	IMP dehydrogenase activity
CVS48_19375	COG1596	polysaccharide export
CVS48_19395	COG0783	Belongs to the Dps family
CVS48_19405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CVS48_19430	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_19440	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS48_19445	COG1178	ABC-type Fe3 transport system permease component
CVS48_19450	COG3842	ATPase activity
CVS48_19455	COG1741	Belongs to the pirin family
CVS48_19460	COG1741	Belongs to the pirin family
CVS48_19465	COG0583	DNA-binding transcription factor activity
CVS48_19470	COG2204	response regulator
CVS48_19475	COG3852	Histidine kinase
CVS48_19485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CVS48_19490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CVS48_19505	COG1960	acyl-CoA dehydrogenase activity
CVS48_19515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CVS48_19520	COG1561	YicC-like family, N-terminal region
CVS48_19525	COG0583	DNA-binding transcription factor activity
CVS48_19530	COG0833	amino acid
CVS48_19535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CVS48_19550	COG0791	NLP P60 protein
CVS48_19555	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_19560	COG2863	cytochrome
CVS48_19565	COG3258	Cytochrome c
CVS48_19570	COG0194	GDP metabolic process
CVS48_19575	COG1758	RNA polymerase activity
CVS48_19580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVS48_19585	COG1126	abc transporter atp-binding protein
CVS48_19590	COG0765	amino acid transport
CVS48_19595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_19635	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_19640	COG4336	lyase activity
CVS48_19655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_19670	COG0583	DNA-binding transcription factor activity
CVS48_19690	COG0560	Phosphoserine phosphatase
CVS48_19695	COG0583	DNA-binding transcription factor activity
CVS48_19700	COG3842	ATPase activity
CVS48_19705	COG1178	ABC-type Fe3 transport system permease component
CVS48_19715	COG4181	ATPase activity
CVS48_19725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS48_19730	COG0584	glycerophosphoryl diester phosphodiesterase
CVS48_19735	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CVS48_19755	COG0678	peroxiredoxin activity
CVS48_19755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CVS48_19770	COG0789	Transcriptional regulator
CVS48_19775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVS48_19780	COG2814	Major facilitator Superfamily
CVS48_19785	COG0583	DNA-binding transcription factor activity
CVS48_19815	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CVS48_19820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CVS48_19825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CVS48_19830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CVS48_19835	COG2252	PERMEase
CVS48_19845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVS48_19850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS48_19870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS48_19880	COG0488	(ABC) transporter
CVS48_19885	COG1619	proteins homologs of microcin C7 resistance protein MccF
CVS48_19890	COG0590	tRNA wobble adenosine to inosine editing
CVS48_19910	COG2212	antiporter activity
CVS48_19915	COG1863	multisubunit Na H antiporter MnhE subunit
CVS48_19920	COG0651	ATP synthesis coupled electron transport
CVS48_19925	COG1006	Multisubunit Na H antiporter MnhC subunit
CVS48_19930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CVS48_19930	COG2111	Na H antiporter
CVS48_19955	COG0420	3'-5' exonuclease activity
CVS48_19960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_19990	COG1960	acyl-CoA dehydrogenase activity
CVS48_19995	COG3634	alkyl hydroperoxide reductase activity
CVS48_20015	COG0395	ABC-type sugar transport system, permease component
CVS48_20025	COG3842	ATPase activity
CVS48_20030	COG3842	ATPase activity
CVS48_20055	COG2130	NADP-dependent
CVS48_20060	COG1309	transcriptional regulator
CVS48_20070	COG1131	(ABC) transporter
CVS48_20075	COG0842	Transport permease protein
CVS48_20090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CVS48_20120	COG1902	pentaerythritol trinitrate reductase activity
CVS48_20135	COG0602	queuosine metabolic process
CVS48_20140	COG0720	synthase
CVS48_20160	COG1566	PFAM secretion protein HlyD family protein
CVS48_20165	COG1538	Outer membrane efflux protein
CVS48_20175	COG0028	Belongs to the TPP enzyme family
CVS48_20185	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_20195	COG0400	carboxylic ester hydrolase activity
CVS48_20200	COG0833	amino acid
CVS48_20215	COG0587	DNA-directed DNA polymerase activity
CVS48_20235	COG0765	amino acid transport
CVS48_20240	COG0765	amino acid transport
CVS48_20245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_20255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS48_20275	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CVS48_20280	COG1414	Transcriptional regulator
CVS48_20300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS48_20305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS48_20315	COG0667	Aldo Keto reductase
CVS48_20325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CVS48_20330	COG1802	Transcriptional regulator
CVS48_20335	COG0747	negative chemotaxis
CVS48_20340	COG0601	transmembrane transport
CVS48_20345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_20350	COG0444	Belongs to the ABC transporter superfamily
CVS48_20355	COG4608	Belongs to the ABC transporter superfamily
CVS48_20380	COG1309	transcriptional regulator
CVS48_20395	COG1683	Conserved Protein
CVS48_20405	COG2207	Transcriptional regulator
CVS48_20415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CVS48_20420	COG1360	Flagellar Motor Protein
CVS48_20425	COG3795	YCII-related domain
CVS48_20430	COG4691	Plasmid stability protein
CVS48_20435	COG1487	ribonuclease activity
CVS48_20440	COG3795	YCII-related domain
CVS48_20450	COG4941	Belongs to the sigma-70 factor family
CVS48_20460	COG0697	spore germination
CVS48_20480	COG2801	Transposase and inactivated derivatives
CVS48_20480	COG3415	Transposase
CVS48_20485	COG0583	DNA-binding transcription factor activity
CVS48_20490	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_20500	COG1846	Transcriptional regulator
CVS48_20510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_20520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CVS48_20545	COG2885	chlorophyll binding
CVS48_20565	COG0024	Methionine aminopeptidase
CVS48_20575	COG0625	glutathione transferase activity
CVS48_20580	COG2032	superoxide dismutase activity
CVS48_20585	COG2733	membrane
CVS48_20590	COG0628	permease
CVS48_20595	COG0583	DNA-binding transcription factor activity
CVS48_20600	COG1024	Enoyl-CoA hydratase
CVS48_20600	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_20605	COG0183	Belongs to the thiolase family
CVS48_20610	COG1960	acyl-CoA dehydrogenase activity
CVS48_20615	COG1960	acyl-CoA dehydrogenase activity
CVS48_20620	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_20665	COG3706	GGDEF domain
CVS48_20665	COG2203	Gaf domain
CVS48_20665	COG4251	negative regulation of phosphorylation
CVS48_20665	COG5001	Diguanylate cyclase
CVS48_20695	COG0840	transmembrane signaling receptor activity
CVS48_20700	COG0154	amidase activity
CVS48_20705	COG0583	DNA-binding transcription factor activity
CVS48_20770	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CVS48_20775	COG1942	4-Oxalocrotonate Tautomerase
CVS48_20780	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_20800	COG4221	oxidoreductase activity
CVS48_20805	COG1902	pentaerythritol trinitrate reductase activity
CVS48_20820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CVS48_20830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS48_20835	COG1132	(ABC) transporter
CVS48_20845	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_20865	COG4221	oxidoreductase activity
CVS48_20870	COG0625	glutathione transferase activity
CVS48_20900	COG0583	DNA-binding transcription factor activity
CVS48_20915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CVS48_20930	COG0519	Catalyzes the synthesis of GMP from XMP
CVS48_20930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVS48_20955	COG0583	DNA-binding transcription factor activity
CVS48_20965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS48_20985	COG0633	Ferredoxin
CVS48_20990	COG0288	reversible hydration of carbon dioxide
CVS48_21010	COG2072	flavoprotein involved in K transport
CVS48_21015	COG0601	transmembrane transport
CVS48_21020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_21025	COG0444	Belongs to the ABC transporter superfamily
CVS48_21030	COG4608	Belongs to the ABC transporter superfamily
CVS48_21035	COG0747	negative chemotaxis
CVS48_21065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CVS48_21075	COG1204	response to ionizing radiation
CVS48_21085	COG3328	transposase activity
CVS48_21090	COG1414	Transcriptional regulator
CVS48_21095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CVS48_21115	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVS48_21120	COG3971	2-oxopent-4-enoate hydratase activity
CVS48_21215	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_21220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_21230	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CVS48_21240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVS48_21250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVS48_21270	COG0583	DNA-binding transcription factor activity
CVS48_21280	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_21290	COG0583	DNA-binding transcription factor activity
CVS48_21295	COG0047	phosphoribosylformylglycinamidine synthase activity
CVS48_21295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CVS48_21310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_21320	COG0613	PHP domain protein
CVS48_21330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVS48_21340	COG0583	DNA-binding transcription factor activity
CVS48_21345	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_21370	COG2146	nitrite reductase [NAD(P)H] activity
CVS48_21370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVS48_21375	COG2146	nitrite reductase [NAD(P)H] activity
CVS48_21375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVS48_21380	COG2116	formate transmembrane transporter activity
CVS48_21385	COG0515	serine threonine protein kinase
CVS48_21395	COG3707	response regulator
CVS48_21400	COG0477	Major facilitator Superfamily
CVS48_21405	COG1846	Transcriptional regulator
CVS48_21415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_21420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_21430	COG1850	ribulose-bisphosphate carboxylase activity
CVS48_21450	COG3210	domain, Protein
CVS48_21450	COG3210	domain, Protein
CVS48_21465	COG1204	response to ionizing radiation
CVS48_21535	COG0583	DNA-binding transcription factor activity
CVS48_21540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVS48_21545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS48_21675	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_21695	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_21700	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_21710	COG0583	DNA-binding transcription factor activity
CVS48_21720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CVS48_21735	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CVS48_21740	COG2814	Major facilitator Superfamily
CVS48_21745	COG4604	ABC transporter, ATP-binding protein
CVS48_21750	COG4605	iron ion homeostasis
CVS48_21760	COG4607	ABC-type enterochelin transport system periplasmic component
CVS48_21765	COG4771	TonB-dependent receptor
CVS48_21770	COG0745	RESPONSE REGULATOR receiver
CVS48_21780	COG4771	TonB-dependent receptor
CVS48_21790	COG1136	(ABC) transporter
CVS48_21815	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_21820	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CVS48_21830	COG1309	transcriptional regulator
CVS48_21840	COG1022	Amp-dependent synthetase and ligase
CVS48_21880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_21890	COG0583	DNA-binding transcription factor activity
CVS48_21895	COG1803	Methylglyoxal synthase
CVS48_21900	COG2975	iron-sulfur cluster assembly
CVS48_21905	COG0633	Ferredoxin
CVS48_21910	COG0443	Heat shock 70 kDa protein
CVS48_21915	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CVS48_21920	COG0316	Belongs to the HesB IscA family
CVS48_21925	COG0822	iron-sulfur transferase activity
CVS48_21930	COG1104	cysteine desulfurase activity
CVS48_21940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CVS48_21945	COG0556	nucleotide-excision repair
CVS48_21955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CVS48_21960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CVS48_21965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CVS48_21970	COG0740	serine-type endopeptidase activity
CVS48_21975	COG0544	peptidyl-prolyl cis-trans isomerase activity
CVS48_21980	COG0501	Belongs to the peptidase M48B family
CVS48_21990	COG1278	Cold shock
CVS48_22005	COG1278	Cold shock
CVS48_22035	COG0583	DNA-binding transcription factor activity
CVS48_22050	COG1309	transcriptional regulator
CVS48_22070	COG3008	intermembrane lipid transfer
CVS48_22075	COG0456	acetyltransferase
CVS48_22085	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CVS48_22100	COG0277	FAD linked oxidase domain protein
CVS48_22105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CVS48_22110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CVS48_22115	COG2271	Major facilitator Superfamily
CVS48_22145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_22150	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_22150	COG1024	Enoyl-CoA hydratase
CVS48_22175	COG2171	N-acyltransferase activity
CVS48_22185	COG2890	protein-(glutamine-N5) methyltransferase activity
CVS48_22190	COG0488	(ABC) transporter
CVS48_22205	COG4771	TonB-dependent receptor
CVS48_22210	COG1858	cytochrome C peroxidase
CVS48_22220	COG0210	DNA helicase
CVS48_22235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS48_22235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVS48_22240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CVS48_22245	COG0196	riboflavin kinase activity
CVS48_22250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CVS48_22255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CVS48_22260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CVS48_22300	COG1902	pentaerythritol trinitrate reductase activity
CVS48_22305	COG1126	abc transporter atp-binding protein
CVS48_22310	COG0765	amino acid transport
CVS48_22315	COG0765	amino acid transport
CVS48_22320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_22330	COG1764	response to oxidative stress
CVS48_22335	COG1914	H( )-stimulated, divalent metal cation uptake system
CVS48_22350	COG2271	Major facilitator Superfamily
CVS48_22360	COG0411	ABC transporter
CVS48_22380	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CVS48_22380	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CVS48_22380	COG0506	proline dehydrogenase activity
CVS48_22390	COG3008	intermembrane lipid transfer
CVS48_22395	COG2995	paraquat-inducible protein a
CVS48_22400	COG0542	response to heat
CVS48_22405	COG4953	penicillin-binding protein 1C
CVS48_22410	COG2373	Large extracellular alpha-helical protein
CVS48_22415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CVS48_22420	COG1278	Cold shock
CVS48_22430	COG0183	Belongs to the thiolase family
CVS48_22435	COG0038	chloride channel
CVS48_22445	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CVS48_22450	COG1570	exodeoxyribonuclease VII activity
CVS48_22455	COG0811	peptide transport
CVS48_22465	COG1663	tetraacyldisaccharide 4'-kinase activity
CVS48_22470	COG2835	tetraacyldisaccharide 4'-kinase activity
CVS48_22475	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CVS48_22480	COG0563	adenylate kinase activity
CVS48_22490	COG0728	peptidoglycan biosynthetic process
CVS48_22500	COG0268	Binds directly to 16S ribosomal RNA
CVS48_22505	COG0583	DNA-binding transcription factor activity
CVS48_22510	COG0019	diaminopimelate decarboxylase activity
CVS48_22525	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_22530	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CVS48_22535	COG2186	Transcriptional regulator
CVS48_22545	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_22555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS48_22585	COG3384	dioxygenase
CVS48_22590	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_22595	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVS48_22605	COG3971	2-oxopent-4-enoate hydratase activity
CVS48_22615	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_22620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CVS48_22625	COG1562	ergosterol biosynthetic process
CVS48_22630	COG1562	ergosterol biosynthetic process
CVS48_22640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CVS48_22660	COG1477	protein flavinylation
CVS48_22675	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CVS48_22685	COG5564	TIM-barrel signal transduction protein
CVS48_22690	COG5441	Belongs to the UPF0261 family
CVS48_22705	COG0542	response to heat
CVS48_22715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CVS48_22750	COG0494	nUDIX hydrolase
CVS48_22755	COG0443	Heat shock 70 kDa protein
CVS48_22775	COG3530	Putative quorum-sensing-regulated virulence factor
CVS48_22810	COG1522	sequence-specific DNA binding
CVS48_22815	COG0488	(ABC) transporter
CVS48_22840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_22850	COG0456	acetyltransferase
CVS48_22865	COG2951	lytic endotransglycosylase activity
CVS48_22885	COG0583	DNA-binding transcription factor activity
CVS48_22890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CVS48_22900	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_22905	COG1473	amidohydrolase
CVS48_22910	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CVS48_22925	COG3618	amidohydrolase
CVS48_22975	COG0444	Belongs to the ABC transporter superfamily
CVS48_22980	COG4608	Belongs to the ABC transporter superfamily
CVS48_22985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_22995	COG0747	negative chemotaxis
CVS48_23005	COG2814	Major facilitator Superfamily
CVS48_23010	COG3708	Transcriptional regulator
CVS48_23010	COG2207	Transcriptional regulator
CVS48_23020	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_23035	COG4942	peptidase
CVS48_23050	COG2169	Transcriptional regulator
CVS48_23075	COG1272	protein, Hemolysin III
CVS48_23095	COG0842	Transport permease protein
CVS48_23100	COG1131	(ABC) transporter
CVS48_23110	COG4948	Mandelate Racemase Muconate Lactonizing
CVS48_23120	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_23130	COG2824	Alkylphosphonate utilization operon protein PhnA
CVS48_23145	COG0348	domain, Protein
CVS48_23165	COG3278	Belongs to the heme-copper respiratory oxidase family
CVS48_23185	COG0156	8-amino-7-oxononanoate synthase activity
CVS48_23195	COG4106	trans-aconitate 2-methyltransferase activity
CVS48_23195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CVS48_23200	COG3609	addiction module antidote protein, CC2985 family
CVS48_23205	COG0583	DNA-binding transcription factor activity
CVS48_23210	COG1064	alcohol dehydrogenase
CVS48_23215	COG2224	Isocitrate lyase
CVS48_23220	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CVS48_23220	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CVS48_23225	COG1473	amidohydrolase
CVS48_23235	COG2814	Major facilitator Superfamily
CVS48_23240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CVS48_23245	COG0322	excinuclease ABC activity
CVS48_23250	COG1472	Belongs to the glycosyl hydrolase 3 family
CVS48_23255	COG0736	holo-[acyl-carrier-protein] synthase activity
CVS48_23260	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CVS48_23265	COG1538	Outer membrane efflux protein
CVS48_23300	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CVS48_23305	COG4149	molybdate abc transporter
CVS48_23310	COG0725	ABC transporter, periplasmic molybdate-binding protein
CVS48_23315	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CVS48_23335	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CVS48_23355	COG4120	Belongs to the binding-protein-dependent transport system permease family
CVS48_23365	COG0667	Aldo Keto reductase
CVS48_23375	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_23380	COG1024	Enoyl-CoA hydratase
CVS48_23390	COG1802	Transcriptional regulator
CVS48_23405	COG1960	acyl-CoA dehydrogenase activity
CVS48_23420	COG1024	Enoyl-CoA hydratase
CVS48_23430	COG0183	Belongs to the thiolase family
CVS48_23435	COG1024	Enoyl-CoA hydratase
CVS48_23440	COG1960	acyl-CoA dehydrogenase activity
CVS48_23450	COG0583	DNA-binding transcription factor activity
CVS48_23455	COG0517	IMP dehydrogenase activity
CVS48_23520	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_23530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CVS48_23535	COG3384	dioxygenase
CVS48_23550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CVS48_23605	COG4964	Belongs to the GSP D family
CVS48_23650	COG1846	Transcriptional regulator
CVS48_23655	COG4172	Belongs to the ABC transporter superfamily
CVS48_23660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_23665	COG0601	transmembrane transport
CVS48_23680	COG0598	Magnesium transport protein CorA
CVS48_23700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CVS48_23710	COG0483	inositol monophosphate 1-phosphatase activity
CVS48_23715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CVS48_23720	COG1045	serine acetyltransferase
CVS48_23725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CVS48_23730	COG0166	Belongs to the GPI family
CVS48_23755	COG1051	belongs to the nudix hydrolase family
CVS48_23775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS48_23805	COG0110	maltose O-acetyltransferase activity
CVS48_23810	COG0297	glycogen (starch) synthase activity
CVS48_23815	COG3415	Transposase
CVS48_23815	COG2801	Transposase and inactivated derivatives
CVS48_23820	COG2197	response regulator
CVS48_23825	COG2197	response regulator
CVS48_23845	COG0183	Belongs to the thiolase family
CVS48_23850	COG1024	Enoyl-CoA hydratase
CVS48_23850	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_23860	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_23860	COG1024	Enoyl-CoA hydratase
CVS48_23865	COG0183	Belongs to the thiolase family
CVS48_23880	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_23890	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_23900	COG4774	siderophore transport
CVS48_23910	COG3395	kinase activity
CVS48_23915	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CVS48_23935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS48_23940	COG0842	Transport permease protein
CVS48_23940	COG1129	ABC transporter
CVS48_23945	COG0842	Transport permease protein
CVS48_23950	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_23955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CVS48_23960	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CVS48_23975	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_23985	COG1414	Transcriptional regulator
CVS48_23995	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CVS48_24025	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CVS48_24040	COG0037	tRNA processing
CVS48_24045	COG0825	malonyl-CoA metabolic process
CVS48_24055	COG0215	cysteine-tRNA ligase activity
CVS48_24070	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS48_24075	COG1968	undecaprenyl-diphosphatase activity
CVS48_24080	COG1253	flavin adenine dinucleotide binding
CVS48_24105	COG0668	transmembrane transport
CVS48_24135	COG0235	Class ii aldolase
CVS48_24150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS48_24155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_24175	COG1802	Transcriptional regulator
CVS48_24195	COG3360	Dodecin
CVS48_24205	COG0583	DNA-binding transcription factor activity
CVS48_24210	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_24490	COG0582	viral genome integration into host DNA
CVS48_24520	COG2916	Histone family protein nucleoid-structuring protein H-NS
CVS48_24605	COG1403	HNH endonuclease
CVS48_24660	COG2850	peptidyl-arginine hydroxylation
CVS48_24670	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CVS48_24675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_24680	COG1994	Peptidase M50
CVS48_24685	COG0009	L-threonylcarbamoyladenylate synthase
CVS48_24690	COG2321	neutral zinc metallopeptidase
CVS48_24745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVS48_24855	COG3756	Protein conserved in bacteria
CVS48_24895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS48_24905	COG1024	Enoyl-CoA hydratase
CVS48_24935	COG1802	Transcriptional regulator
CVS48_24950	COG2197	response regulator
CVS48_24975	COG3121	Chaperone
CVS48_24980	COG3188	usher protein
CVS48_24995	COG2271	Major facilitator Superfamily
CVS48_25000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_25020	COG0028	Belongs to the TPP enzyme family
CVS48_25025	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_25030	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_25045	COG1414	Transcriptional regulator
CVS48_25050	COG0583	DNA-binding transcription factor activity
CVS48_25060	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_25075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CVS48_25080	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CVS48_25085	COG2080	2 iron, 2 sulfur cluster binding
CVS48_25105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS48_25105	COG1042	CoA-binding domain protein
CVS48_25105	COG0045	succinate-CoA ligase (ADP-forming) activity
CVS48_25110	COG1024	Enoyl-CoA hydratase
CVS48_25120	COG1228	amidohydrolase
CVS48_25135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_25150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_25155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CVS48_25160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CVS48_25165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_25170	COG3485	protocatechuate 3,4-dioxygenase
CVS48_25175	COG3485	protocatechuate 3,4-dioxygenase
CVS48_25190	COG1278	Cold shock
CVS48_25215	COG2070	2-Nitropropane dioxygenase
CVS48_25225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_25240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_25245	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_25250	COG1024	Enoyl-CoA hydratase
CVS48_25305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_25310	COG0765	amino acid transport
CVS48_25330	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_25340	COG2423	ornithine cyclodeaminase activity
CVS48_25345	COG0601	transmembrane transport
CVS48_25350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_25355	COG0747	negative chemotaxis
CVS48_25360	COG0402	S-adenosylhomocysteine deaminase activity
CVS48_25365	COG4172	Belongs to the ABC transporter superfamily
CVS48_25375	COG0583	DNA-binding transcription factor activity
CVS48_25395	COG2197	response regulator
CVS48_25400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS48_25405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_25410	COG1116	anion transmembrane transporter activity
CVS48_25415	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CVS48_25420	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CVS48_25435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS48_25505	COG1396	sequence-specific DNA binding
CVS48_25510	COG0235	Class ii aldolase
CVS48_25515	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_25540	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_25545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_25550	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CVS48_25565	COG0183	Belongs to the thiolase family
CVS48_25570	COG1024	Enoyl-CoA hydratase
CVS48_25570	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_25580	COG1063	alcohol dehydrogenase
CVS48_25600	COG0071	Belongs to the small heat shock protein (HSP20) family
CVS48_25635	COG4585	Histidine kinase
CVS48_25660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS48_25680	COG2192	nodulation
CVS48_25690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CVS48_25695	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_25700	COG0438	transferase activity, transferring glycosyl groups
CVS48_25705	COG5265	(ABC) transporter
CVS48_25715	COG0463	Glycosyl transferase, family 2
CVS48_25740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CVS48_25745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CVS48_25750	COG3546	catalase activity
CVS48_25790	COG2201	protein-glutamate methylesterase activity
CVS48_25810	COG0668	transmembrane transport
CVS48_25820	COG1546	Belongs to the CinA family
CVS48_25820	COG1058	Belongs to the CinA family
CVS48_25835	COG3485	protocatechuate 3,4-dioxygenase
CVS48_25840	COG3485	protocatechuate 3,4-dioxygenase
CVS48_25850	COG2271	Major facilitator Superfamily
CVS48_25860	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_25875	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_25880	COG1960	acyl-CoA dehydrogenase activity
CVS48_25885	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_25890	COG0183	Belongs to the thiolase family
CVS48_25900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_25920	COG4176	ABC-type proline glycine betaine transport system permease component
CVS48_25930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVS48_25935	COG2814	Major facilitator Superfamily
CVS48_25940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CVS48_25945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CVS48_25975	COG1686	Belongs to the peptidase S11 family
CVS48_25985	COG1846	Transcriptional regulator
CVS48_25990	COG2814	Major facilitator Superfamily
CVS48_25995	COG0495	leucyl-tRNA aminoacylation
CVS48_26010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CVS48_26025	COG0154	amidase activity
CVS48_26035	COG0477	Major facilitator Superfamily
CVS48_26040	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_26055	COG0583	DNA-binding transcription factor activity
CVS48_26065	COG0235	Class ii aldolase
CVS48_26095	COG1530	ribonuclease E activity
CVS48_26105	COG4251	negative regulation of phosphorylation
CVS48_26105	COG2203	Gaf domain
CVS48_26105	COG5001	Diguanylate cyclase
CVS48_26105	COG3706	GGDEF domain
CVS48_26115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CVS48_26115	COG0475	glutathione-regulated potassium exporter activity
CVS48_26120	COG1132	(ABC) transporter
CVS48_26145	COG0726	polysaccharide deacetylase
CVS48_26150	COG0438	transferase activity, transferring glycosyl groups
CVS48_26160	COG0726	polysaccharide deacetylase
CVS48_26165	COG0438	transferase activity, transferring glycosyl groups
CVS48_26180	COG1643	Atp-dependent helicase
CVS48_26185	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CVS48_26185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CVS48_26190	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CVS48_26200	COG0704	Plays a role in the regulation of phosphate uptake
CVS48_26205	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CVS48_26210	COG1960	acyl-CoA dehydrogenase activity
CVS48_26230	COG2094	Belongs to the DNA glycosylase MPG family
CVS48_26240	COG1177	transmembrane transport
CVS48_26245	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS48_26250	COG3842	ATPase activity
CVS48_26255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CVS48_26260	COG3642	lipopolysaccharide core region biosynthetic process
CVS48_26270	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CVS48_26275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_26290	COG4608	Belongs to the ABC transporter superfamily
CVS48_26295	COG0444	Belongs to the ABC transporter superfamily
CVS48_26320	COG0747	negative chemotaxis
CVS48_26340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVS48_26345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CVS48_26375	COG0583	DNA-binding transcription factor activity
CVS48_26380	COG0137	argininosuccinate synthase activity
CVS48_26385	COG3158	transport of potassium into the cell
CVS48_26390	COG0642	Histidine kinase
CVS48_26395	COG0745	RESPONSE REGULATOR receiver
CVS48_26420	COG0776	regulation of translation
CVS48_26425	COG3128	pkhd-type hydroxylase
CVS48_26430	COG0626	cystathionine gamma-synthase activity
CVS48_26435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVS48_26440	COG0557	exoribonuclease II activity
CVS48_26465	COG2153	protein acetylation
CVS48_26480	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CVS48_26485	COG2391	methyltransferase activity
CVS48_26490	COG0069	glutamate synthase activity
CVS48_26495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS48_26505	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CVS48_26510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CVS48_26540	COG0697	spore germination
CVS48_26585	COG3909	cytochrome
CVS48_26595	COG0625	glutathione transferase activity
CVS48_26600	COG0730	response to heat
CVS48_26605	COG0482	sulfurtransferase activity
CVS48_26610	COG0583	DNA-binding transcription factor activity
CVS48_26625	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CVS48_26630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CVS48_26635	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CVS48_26640	COG0247	lactate metabolic process
CVS48_26645	COG0277	FAD linked oxidase domain protein
CVS48_26650	COG0277	FAD linked oxidase domain protein
CVS48_26655	COG0277	FAD linked oxidase domain protein
CVS48_26660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS48_26665	COG0312	modulator of DNA gyrase
CVS48_26680	COG0308	aminopeptidase N
CVS48_26685	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CVS48_26705	COG0436	Aminotransferase
CVS48_26715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CVS48_26720	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CVS48_26740	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_26750	COG0411	ABC transporter
CVS48_26770	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_26780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CVS48_26800	COG0181	hydroxymethylbilane synthase activity
CVS48_26805	COG0861	Integral membrane protein TerC family
CVS48_26810	COG0861	Integral membrane protein TerC family
CVS48_26815	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CVS48_26820	COG0045	succinate-CoA ligase (ADP-forming) activity
CVS48_26830	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CVS48_26835	COG0583	DNA-binding transcription factor activity
CVS48_26840	COG2137	regulation of response to DNA damage stimulus
CVS48_26845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CVS48_26855	COG0642	Histidine kinase
CVS48_26880	COG0540	Belongs to the ATCase OTCase family
CVS48_26910	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CVS48_26930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_26965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CVS48_26975	COG0305	Participates in initiation and elongation during chromosome replication
CVS48_26985	COG0359	binds to the 23S rRNA
CVS48_26990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CVS48_26995	COG2965	DNA replication, synthesis of RNA primer
CVS48_27000	COG0360	Binds together with S18 to 16S ribosomal RNA
CVS48_27005	COG3739	integral membrane protein
CVS48_27010	COG1469	GTP cyclohydrolase I activity
CVS48_27015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CVS48_27020	COG0142	geranyltranstransferase activity
CVS48_27025	COG1722	exodeoxyribonuclease VII activity
CVS48_27035	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_27050	COG0492	ferredoxin-NADP+ reductase activity
CVS48_27060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS48_27070	COG3842	ATPase activity
CVS48_27095	COG0501	Belongs to the peptidase M48B family
CVS48_27100	COG1760	l-serine dehydratase
CVS48_27105	COG1283	sodium-dependent phosphate transmembrane transporter activity
CVS48_27110	COG0412	Dienelactone hydrolase
CVS48_27115	COG0428	transporter
CVS48_27125	COG1611	Belongs to the LOG family
CVS48_27135	COG0583	DNA-binding transcription factor activity
CVS48_27150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CVS48_27155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CVS48_27160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CVS48_27165	COG0195	Participates in both transcription termination and antitermination
CVS48_27165	COG2251	uridine kinase activity
CVS48_27170	COG0779	Required for maturation of 30S ribosomal subunits
CVS48_27175	COG1187	pseudouridine synthase activity
CVS48_27180	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CVS48_27190	COG0583	DNA-binding transcription factor activity
CVS48_27195	COG0523	cobalamin synthesis protein
CVS48_27210	COG0745	RESPONSE REGULATOR receiver
CVS48_27215	COG0642	Histidine kinase
CVS48_27220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVS48_27225	COG0625	glutathione transferase activity
CVS48_27240	COG2003	Belongs to the UPF0758 family
CVS48_27245	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CVS48_27250	COG3483	tryptophan 2,3-dioxygenase activity
CVS48_27255	COG0254	rRNA binding
CVS48_27265	COG0534	Mate efflux family protein
CVS48_27275	COG2050	protein possibly involved in aromatic compounds catabolism
CVS48_27280	COG1024	Enoyl-CoA hydratase
CVS48_27285	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_27290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS48_27295	COG2151	metal-sulfur cluster biosynthetic enzyme
CVS48_27300	COG3396	Phenylacetate-CoA oxygenase
CVS48_27305	COG3460	Phenylacetate-CoA oxygenase
CVS48_27310	COG3396	Phenylacetate-CoA oxygenase
CVS48_27315	COG3327	negative regulation of DNA-templated transcription, initiation
CVS48_27320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CVS48_27325	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CVS48_27330	COG0501	Belongs to the peptidase M48B family
CVS48_27335	COG1162	GTPase activity
CVS48_27350	COG0335	large ribosomal subunit rRNA binding
CVS48_27370	COG2895	sulfate adenylyltransferase (ATP) activity
CVS48_27380	COG0175	sulfate reduction
CVS48_27385	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CVS48_27390	COG4208	sulfate ABC transporter
CVS48_27405	COG0450	alkyl hydroperoxide reductase
CVS48_27410	COG1960	acyl-CoA dehydrogenase activity
CVS48_27415	COG2985	domain, Protein
CVS48_27440	COG0123	including yeast histone deacetylase and acetoin utilization protein
CVS48_27445	COG2951	lytic endotransglycosylase activity
CVS48_27470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS48_27475	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CVS48_27480	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CVS48_27500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CVS48_27505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CVS48_27510	COG0287	Prephenate dehydrogenase
CVS48_27525	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CVS48_27540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CVS48_27560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CVS48_27570	COG1215	transferase activity, transferring glycosyl groups
CVS48_27590	COG2951	lytic endotransglycosylase activity
CVS48_27595	COG2258	MOSC domain
CVS48_27600	COG2833	Protein of unknown function (DUF455)
CVS48_27615	COG1132	(ABC) transporter
CVS48_27620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CVS48_27620	COG0189	ligase activity
CVS48_27625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CVS48_27625	COG0189	ligase activity
CVS48_27630	COG3237	CsbD-like
CVS48_27670	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CVS48_27675	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_27680	COG3243	poly(R)-hydroxyalkanoic acid synthase
CVS48_27690	COG0564	pseudouridine synthase activity
CVS48_27700	COG1199	ATP-dependent helicase activity
CVS48_27705	COG2183	response to ionizing radiation
CVS48_27715	COG0180	Tryptophanyl-tRNA synthetase
CVS48_27740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_27750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_27760	COG0483	inositol monophosphate 1-phosphatase activity
CVS48_27775	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS48_27780	COG4774	siderophore transport
CVS48_27785	COG3712	iron ion homeostasis
CVS48_27790	COG1595	DNA-templated transcription, initiation
CVS48_27795	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CVS48_27800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS48_27805	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS48_27810	COG0567	Dehydrogenase, E1 component
CVS48_27815	COG1522	sequence-specific DNA binding
CVS48_27820	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CVS48_27845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS48_27850	COG2233	PERMEase
CVS48_27855	COG1297	OPT oligopeptide transporter protein
CVS48_27865	COG0280	phosphate acetyltransferase
CVS48_27865	COG0281	malic enzyme
CVS48_27885	COG0372	Belongs to the citrate synthase family
CVS48_27890	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CVS48_27895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CVS48_27900	COG1053	succinate dehydrogenase
CVS48_27905	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CVS48_27910	COG2009	succinate dehydrogenase
CVS48_27915	COG2188	Transcriptional regulator
CVS48_27920	COG0039	L-malate dehydrogenase activity
CVS48_27935	COG2079	MmgE PrpD family protein
CVS48_27975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CVS48_27985	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CVS48_27990	COG0148	phosphopyruvate hydratase activity
CVS48_28005	COG0504	CTP synthase activity
CVS48_28015	COG3415	Transposase
CVS48_28015	COG2801	Transposase and inactivated derivatives
CVS48_28040	COG0601	transmembrane transport
CVS48_28045	COG0747	negative chemotaxis
CVS48_28050	COG4172	Belongs to the ABC transporter superfamily
CVS48_28055	COG1446	asparaginase
CVS48_28065	COG2153	protein acetylation
CVS48_28130	COG1802	Transcriptional regulator
CVS48_28140	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CVS48_28145	COG0697	spore germination
CVS48_28160	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CVS48_28165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVS48_28170	COG0791	NLP P60 protein
CVS48_28180	COG0583	DNA-binding transcription factor activity
CVS48_28205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CVS48_28225	COG0667	Aldo Keto reductase
CVS48_28235	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_28245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CVS48_28255	COG1381	Involved in DNA repair and RecF pathway recombination
CVS48_28260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CVS48_28265	COG0571	ribonuclease III activity
CVS48_28270	COG0681	Belongs to the peptidase S26 family
CVS48_28275	COG0481	GTPase activity
CVS48_28280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVS48_28305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS48_28310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVS48_28320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CVS48_28325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVS48_28330	COG0416	fatty acid biosynthetic process
CVS48_28335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CVS48_28340	COG1399	metal-binding, possibly nucleic acid-binding protein
CVS48_28345	COG0424	maF-like protein
CVS48_28355	COG3023	N-Acetylmuramoyl-L-alanine amidase
CVS48_28360	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CVS48_28365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CVS48_28380	COG1530	ribonuclease E activity
CVS48_28385	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CVS48_28390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CVS48_28395	COG0159	tryptophan synthase activity
CVS48_28400	COG0133	tryptophan synthase activity
CVS48_28405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS48_28415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVS48_28420	COG3228	Belongs to the MtfA family
CVS48_28430	COG0251	oxidation-reduction process
CVS48_28440	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CVS48_28455	COG2878	Part of a membrane complex involved in electron transport
CVS48_28460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CVS48_28465	COG0411	ABC transporter
CVS48_28495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CVS48_28500	COG0410	ABC transporter
CVS48_28505	COG0411	ABC transporter
CVS48_28520	COG1268	BioY protein
CVS48_28525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CVS48_28530	COG1122	ATPase activity
CVS48_28535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVS48_28540	COG2917	probably involved in intracellular septation
CVS48_28555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CVS48_28565	COG1196	nuclear chromosome segregation
CVS48_28570	COG0477	Major facilitator Superfamily
CVS48_28575	COG1573	uracil-dna glycosylase
CVS48_28580	COG1214	PFAM Peptidase M22, glycoprotease
CVS48_28585	COG0745	RESPONSE REGULATOR receiver
CVS48_28590	COG2205	protein histidine kinase activity
CVS48_28595	COG0450	alkyl hydroperoxide reductase
CVS48_28600	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVS48_28610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CVS48_28615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CVS48_28620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CVS48_28625	COG0560	Phosphoserine phosphatase
CVS48_28630	COG4774	siderophore transport
CVS48_28640	COG1007	ATP synthesis coupled electron transport
CVS48_28655	COG0713	ATP synthesis coupled electron transport
CVS48_28665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS48_28670	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CVS48_28675	COG1034	ATP synthesis coupled electron transport
CVS48_28685	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CVS48_28690	COG0649	NAD binding
CVS48_28695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS48_28700	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS48_28705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS48_28710	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_28735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CVS48_28755	COG0583	DNA-binding transcription factor activity
CVS48_28770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS48_28775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS48_28780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CVS48_28790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS48_28795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS48_28810	COG4166	transmembrane transport
CVS48_28815	COG4166	transmembrane transport
CVS48_28825	COG4172	Belongs to the ABC transporter superfamily
CVS48_28845	COG2354	Protein conserved in bacteria
CVS48_28855	COG1278	Cold shock
CVS48_28880	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_28885	COG2851	Citrate transporter
CVS48_28915	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_28960	COG2203	Gaf domain
CVS48_28960	COG2199	diguanylate cyclase activity
CVS48_28990	COG2365	Tyrosine phosphatase family
CVS48_29020	COG1595	DNA-templated transcription, initiation
CVS48_29025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CVS48_29030	COG0149	triose-phosphate isomerase activity
CVS48_29045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_29055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_29090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVS48_29100	COG1185	polyribonucleotide nucleotidyltransferase activity
CVS48_29105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CVS48_29115	COG1183	phosphatidylcholine synthase activity
CVS48_29120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CVS48_29125	COG0440	acetolactate synthase activity