locus-tag	class	description
LH59_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LH59_00010	COG0592	DNA-directed DNA polymerase activity
LH59_00020	COG0583	DNA-binding transcription factor activity
LH59_00045	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LH59_00055	COG0583	DNA-binding transcription factor activity
LH59_00060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_00065	COG0765	amino acid transport
LH59_00070	COG0765	amino acid transport
LH59_00075	COG1126	abc transporter atp-binding protein
LH59_00090	COG1254	Belongs to the acylphosphatase family
LH59_00100	COG1304	FMN binding
LH59_00115	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH59_00120	COG1177	transmembrane transport
LH59_00175	COG1609	Transcriptional regulator
LH59_00185	COG3842	ATPase activity
LH59_00190	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH59_00195	COG1177	transmembrane transport
LH59_00220	COG0251	oxidation-reduction process
LH59_00225	COG0402	S-adenosylhomocysteine deaminase activity
LH59_00245	COG1744	ABC transporter substrate-binding protein PnrA-like
LH59_00255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LH59_00270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH59_00285	COG2814	Major facilitator Superfamily
LH59_00290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LH59_00300	COG3781	membrane
LH59_00305	COG1522	sequence-specific DNA binding
LH59_00310	COG0028	Belongs to the TPP enzyme family
LH59_00315	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_00320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_00325	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LH59_00345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH59_00350	COG2922	Belongs to the Smg family
LH59_00380	COG0765	amino acid transport
LH59_00385	COG0765	amino acid transport
LH59_00390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_00400	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_00405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LH59_00415	COG4977	sequence-specific DNA binding
LH59_00420	COG2814	Major facilitator Superfamily
LH59_00430	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
LH59_00440	COG3339	Conserved Protein
LH59_00470	COG2186	Transcriptional regulator
LH59_00475	COG2814	Major facilitator Superfamily
LH59_00490	COG1595	DNA-templated transcription, initiation
LH59_00495	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_00510	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_00520	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_00560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LH59_00565	COG0183	Belongs to the thiolase family
LH59_00570	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LH59_00575	COG1960	acyl-CoA dehydrogenase activity
LH59_00580	COG1473	amidohydrolase
LH59_00590	COG1742	UPF0060 membrane protein
LH59_00605	COG1280	lysine exporter protein (LysE YggA)
LH59_00630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LH59_00640	COG0018	arginyl-trna synthetase
LH59_00655	COG0395	ABC-type sugar transport system, permease component
LH59_00660	COG1175	transmembrane transport
LH59_00665	COG1653	transport
LH59_00670	COG3842	ATPase activity
LH59_00675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH59_00680	COG1609	Transcriptional regulator
LH59_00690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH59_00705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LH59_00725	COG0583	DNA-binding transcription factor activity
LH59_00750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LH59_00755	COG1280	lysine exporter protein (LysE YggA)
LH59_00765	COG0513	Belongs to the DEAD box helicase family
LH59_00770	COG5339	Protein conserved in bacteria
LH59_00775	COG5339	Protein conserved in bacteria
LH59_00780	COG1228	amidohydrolase
LH59_00790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_00800	COG0747	negative chemotaxis
LH59_00805	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LH59_00815	COG2207	Transcriptional regulator
LH59_00815	COG3708	Transcriptional regulator
LH59_00835	COG0583	DNA-binding transcription factor activity
LH59_00865	COG2969	positive regulation of protein catabolic process
LH59_00870	COG0625	glutathione transferase activity
LH59_00875	COG2857	Cytochrome c1
LH59_00880	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LH59_00885	COG0723	plastoquinol--plastocyanin reductase activity
LH59_00890	COG1970	mechanosensitive ion channel activity
LH59_00895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LH59_00900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH59_00915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LH59_00920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LH59_00925	COG0537	adenosine 5'-monophosphoramidase activity
LH59_00930	COG0140	phosphoribosyl-ATP diphosphatase activity
LH59_00935	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LH59_00940	COG0107	imidazoleglycerol-phosphate synthase activity
LH59_00945	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LH59_00950	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LH59_00955	COG0131	Imidazoleglycerol-phosphate dehydratase
LH59_00960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LH59_00965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LH59_00970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LH59_00975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LH59_00985	COG0842	Transport permease protein
LH59_00990	COG1131	(ABC) transporter
LH59_01000	COG2853	Lipoprotein
LH59_01005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LH59_01010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LH59_01015	COG1127	ABC transporter
LH59_01020	COG2070	2-Nitropropane dioxygenase
LH59_01030	COG0477	Major facilitator Superfamily
LH59_01045	COG0583	DNA-binding transcription factor activity
LH59_01050	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LH59_01055	COG0511	ligase activity, forming carbon-carbon bonds
LH59_01070	COG1984	allophanate hydrolase subunit 2
LH59_01085	COG0070	glutamate synthase
LH59_01085	COG0067	glutamate synthase
LH59_01085	COG0069	glutamate synthase activity
LH59_01110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH59_01130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH59_01165	COG1612	heme a metabolic process
LH59_01170	COG0109	protoheme IX farnesyltransferase activity
LH59_01175	COG1999	signal sequence binding
LH59_01195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LH59_01200	COG2814	Major facilitator Superfamily
LH59_01210	COG0438	transferase activity, transferring glycosyl groups
LH59_01220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LH59_01235	COG1959	2 iron, 2 sulfur cluster binding
LH59_01240	COG2814	Major facilitator Superfamily
LH59_01250	COG4774	siderophore transport
LH59_01255	COG4592	Periplasmic binding protein
LH59_01260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_01265	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_01270	COG1120	ATPase activity
LH59_01290	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LH59_01315	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LH59_01320	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LH59_01325	COG2814	Major facilitator Superfamily
LH59_01330	COG0583	DNA-binding transcription factor activity
LH59_01340	COG2423	ornithine cyclodeaminase activity
LH59_01345	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LH59_01350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LH59_01360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH59_01370	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LH59_01375	COG0463	Glycosyl transferase, family 2
LH59_01425	COG0737	Belongs to the 5'-nucleotidase family
LH59_01440	COG2188	Transcriptional regulator
LH59_01450	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LH59_01455	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LH59_01470	COG0840	transmembrane signaling receptor activity
LH59_01475	COG2814	Major facilitator Superfamily
LH59_01490	COG3188	usher protein
LH59_01550	COG1802	Transcriptional regulator
LH59_01560	COG3069	C4-dicarboxylate transmembrane transporter activity
LH59_01565	COG1012	belongs to the aldehyde dehydrogenase family
LH59_01590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_01600	COG0747	negative chemotaxis
LH59_01625	COG1464	Belongs to the NlpA lipoprotein family
LH59_01630	COG0431	NADPH-dependent FMN reductase
LH59_01635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_01640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH59_01645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_01660	COG2011	ABC-type metal ion transport system permease component
LH59_01665	COG1464	Belongs to the NlpA lipoprotein family
LH59_01670	COG1116	anion transmembrane transporter activity
LH59_01675	COG3585	molybdate ion transport
LH59_01680	COG3064	Membrane
LH59_01705	COG1607	acyl-coa hydrolase
LH59_01715	COG0243	molybdopterin cofactor binding
LH59_01715	COG3383	formate dehydrogenase (NAD+) activity
LH59_01720	COG3383	formate dehydrogenase (NAD+) activity
LH59_01720	COG0243	molybdopterin cofactor binding
LH59_01725	COG0437	4 iron, 4 sulfur cluster binding
LH59_01730	COG2864	formate dehydrogenase
LH59_01745	COG3276	selenocysteine insertion sequence binding
LH59_01755	COG1216	Glycosyl transferase, family 2
LH59_01760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH59_01765	COG1305	Transglutaminase-like
LH59_01770	COG0709	Synthesizes selenophosphate from selenide and ATP
LH59_01805	COG1012	belongs to the aldehyde dehydrogenase family
LH59_01810	COG3284	Transcriptional regulator
LH59_01815	COG0134	indole-3-glycerol-phosphate synthase activity
LH59_01820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LH59_01825	COG0512	Glutamine amidotransferase of anthranilate synthase
LH59_01835	COG0546	phosphoglycolate phosphatase activity
LH59_01845	COG2967	ApaG domain
LH59_01855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH59_01860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LH59_01870	COG0037	tRNA processing
LH59_01885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH59_01900	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_01905	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_01920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH59_01945	COG3473	Maleate cis-trans isomerase
LH59_01950	COG0583	DNA-binding transcription factor activity
LH59_01965	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LH59_01975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH59_01980	COG1024	Enoyl-CoA hydratase
LH59_01995	COG0356	it plays a direct role in the translocation of protons across the membrane
LH59_02005	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LH59_02010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LH59_02015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LH59_02020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LH59_02025	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LH59_02030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LH59_02040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LH59_02045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LH59_02050	COG0210	DNA helicase
LH59_02065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LH59_02080	COG2171	N-acyltransferase activity
LH59_02090	COG2195	Cleaves the N-terminal amino acid of tripeptides
LH59_02100	COG4608	Belongs to the ABC transporter superfamily
LH59_02105	COG0444	Belongs to the ABC transporter superfamily
LH59_02115	COG0601	transmembrane transport
LH59_02120	COG0747	negative chemotaxis
LH59_02125	COG2988	succinylglutamate desuccinylase activity
LH59_02140	COG0747	negative chemotaxis
LH59_02150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LH59_02155	COG1024	Enoyl-CoA hydratase
LH59_02160	COG1024	Enoyl-CoA hydratase
LH59_02170	COG1309	transcriptional regulator
LH59_02185	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_02200	COG2814	Major facilitator Superfamily
LH59_02215	COG1764	response to oxidative stress
LH59_02220	COG0583	DNA-binding transcription factor activity
LH59_02230	COG1595	DNA-templated transcription, initiation
LH59_02235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH59_02255	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH59_02265	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_02275	COG1129	ABC transporter
LH59_02290	COG1802	Transcriptional regulator
LH59_02300	COG0583	DNA-binding transcription factor activity
LH59_02310	COG2988	succinylglutamate desuccinylase activity
LH59_02320	COG2918	glutathione biosynthetic process
LH59_02350	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LH59_02355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH59_02365	COG2721	sulfolactate sulfo-lyase activity
LH59_02370	COG2721	sulfolactate sulfo-lyase activity
LH59_02375	COG2188	Transcriptional regulator
LH59_02380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH59_02385	COG2813	Specifically methylates the guanine in position
LH59_02385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH59_02390	COG2223	nitrite transmembrane transporter activity
LH59_02400	COG2860	membrane
LH59_02405	COG1802	Transcriptional regulator
LH59_02410	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LH59_02415	COG1984	allophanate hydrolase subunit 2
LH59_02420	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LH59_02430	COG0583	DNA-binding transcription factor activity
LH59_02440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH59_02455	COG2132	Multicopper oxidase
LH59_02480	COG0745	RESPONSE REGULATOR receiver
LH59_02485	COG2226	methyltransferase
LH59_02500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LH59_02510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LH59_02520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LH59_02525	COG0351	phosphomethylpyrimidine kinase
LH59_02530	COG2022	thiamine diphosphate biosynthetic process
LH59_02535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LH59_02540	COG4771	TonB-dependent receptor
LH59_02550	COG2186	Transcriptional regulator
LH59_02565	COG1063	alcohol dehydrogenase
LH59_02575	COG0765	amino acid transport
LH59_02580	COG1126	abc transporter atp-binding protein
LH59_02585	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_02590	COG0246	Mannitol dehydrogenase
LH59_02625	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LH59_02630	COG2177	Part of the ABC transporter FtsEX involved in
LH59_02635	COG2884	Cell division ATP-binding protein ftsE
LH59_02640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_02645	COG4597	amino acid ABC transporter
LH59_02650	COG0765	amino acid transport
LH59_02655	COG1126	abc transporter atp-binding protein
LH59_02675	COG0410	ABC transporter
LH59_02680	COG1129	ABC transporter
LH59_02685	COG4177	L-phenylalanine transmembrane transporter activity
LH59_02690	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_02700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH59_02705	COG2081	HI0933 family
LH59_02715	COG1605	Chorismate mutase
LH59_02715	COG0077	Prephenate dehydratase
LH59_02745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LH59_02750	COG0477	Major facilitator Superfamily
LH59_02760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LH59_02765	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LH59_02785	COG0237	dephospho-CoA kinase activity
LH59_02790	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LH59_02820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_02825	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LH59_02840	COG3833	ABC-type maltose transport systems, permease component
LH59_02845	COG1175	transmembrane transport
LH59_02850	COG3842	ATPase activity
LH59_02870	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LH59_02890	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_02905	COG0410	ABC transporter
LH59_02925	COG3706	GGDEF domain
LH59_02940	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_02945	COG1024	Enoyl-CoA hydratase
LH59_02985	COG4638	Rieske (2fe-2S)
LH59_02990	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LH59_02995	COG1335	isochorismatase
LH59_03000	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_03010	COG0741	lytic transglycosylase activity
LH59_03015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LH59_03035	COG1678	Uncharacterized ACR, COG1678
LH59_03040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LH59_03070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LH59_03080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_03090	COG0765	amino acid transport
LH59_03095	COG1126	abc transporter atp-binding protein
LH59_03100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LH59_03110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LH59_03115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LH59_03130	COG1175	transmembrane transport
LH59_03140	COG0642	Histidine kinase
LH59_03150	COG0557	exoribonuclease II activity
LH59_03155	COG3150	esterase
LH59_03160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LH59_03165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH59_03170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LH59_03175	COG0511	ligase activity, forming carbon-carbon bonds
LH59_03180	COG0439	Biotin carboxylase
LH59_03185	COG2264	protein methyltransferase activity
LH59_03195	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LH59_03195	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LH59_03220	COG1696	Membrane protein involved in D-alanine export
LH59_03225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LH59_03260	COG1522	sequence-specific DNA binding
LH59_03265	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_03275	COG0583	DNA-binding transcription factor activity
LH59_03290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH59_03295	COG0045	succinate-CoA ligase (ADP-forming) activity
LH59_03295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH59_03295	COG1042	CoA-binding domain protein
LH59_03300	COG1335	isochorismatase
LH59_03305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_03310	COG1116	anion transmembrane transporter activity
LH59_03325	COG3028	Belongs to the UPF0307 family
LH59_03330	COG0312	modulator of DNA gyrase
LH59_03335	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LH59_03345	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_03350	COG4177	L-phenylalanine transmembrane transporter activity
LH59_03365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LH59_03370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LH59_03375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LH59_03385	COG0316	Belongs to the HesB IscA family
LH59_03390	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LH59_03400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LH59_03415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LH59_03420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LH59_03430	COG1335	isochorismatase
LH59_03435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH59_03435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH59_03450	COG2766	serine protein kinase
LH59_03455	COG2718	Belongs to the UPF0229 family
LH59_03460	COG2719	SpoVR family
LH59_03470	COG0583	DNA-binding transcription factor activity
LH59_03475	COG1942	4-Oxalocrotonate Tautomerase
LH59_03485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LH59_03495	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_03515	COG2770	Histidine kinase
LH59_03515	COG2208	phosphoserine phosphatase activity
LH59_03525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LH59_03530	COG2172	sigma factor antagonist activity
LH59_03535	COG1366	Belongs to the anti-sigma-factor antagonist family
LH59_03575	COG0741	lytic transglycosylase activity
LH59_03575	COG1388	LysM domain
LH59_03580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH59_03585	COG2226	methyltransferase
LH59_03590	COG0328	RNA-DNA hybrid ribonuclease activity
LH59_03600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH59_03605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LH59_03620	COG1671	Belongs to the UPF0178 family
LH59_03635	COG0786	glutamate:sodium symporter activity
LH59_03645	COG0463	Glycosyl transferase, family 2
LH59_03650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LH59_03665	COG0583	DNA-binding transcription factor activity
LH59_03685	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_03705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_03715	COG0583	DNA-binding transcription factor activity
LH59_03725	COG1346	cytolysis
LH59_03735	COG0697	spore germination
LH59_03740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_03755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LH59_03765	COG1522	sequence-specific DNA binding
LH59_03780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LH59_03785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_03800	COG0823	Involved in the tonB-independent uptake of proteins
LH59_03810	COG0848	biopolymer transport protein
LH59_03815	COG0811	peptide transport
LH59_03820	COG0824	Thioesterase
LH59_03825	COG0442	prolyl-tRNA aminoacylation
LH59_03855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH59_03865	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LH59_03870	COG2084	Dehydrogenase
LH59_03875	COG0405	Gamma-glutamyltransferase
LH59_03910	COG0129	dihydroxy-acid dehydratase activity
LH59_03915	COG4654	Cytochrome c, class I
LH59_03920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH59_03930	COG1522	sequence-specific DNA binding
LH59_03980	COG0583	DNA-binding transcription factor activity
LH59_03990	COG1473	amidohydrolase
LH59_03995	COG0418	dihydroorotase activity
LH59_04005	COG2001	Belongs to the MraZ family
LH59_04010	COG0275	rRNA processing
LH59_04015	COG3116	cell division
LH59_04025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH59_04030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH59_04035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LH59_04045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LH59_04050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LH59_04055	COG1181	Belongs to the D-alanine--D-alanine ligase family
LH59_04060	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LH59_04070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LH59_04075	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LH59_04085	COG0739	heme binding
LH59_04090	COG0653	protein targeting
LH59_04105	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_04110	COG0028	Belongs to the TPP enzyme family
LH59_04120	COG0300	oxidoreductase activity
LH59_04125	COG1522	sequence-specific DNA binding
LH59_04140	COG2239	Acts as a magnesium transporter
LH59_04145	COG1607	acyl-coa hydrolase
LH59_04150	COG2855	membrane
LH59_04155	COG0583	DNA-binding transcription factor activity
LH59_04160	COG1473	amidohydrolase
LH59_04165	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_04170	COG0483	inositol monophosphate 1-phosphatase activity
LH59_04175	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LH59_04175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_04180	COG1501	Belongs to the glycosyl hydrolase 31 family
LH59_04185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LH59_04190	COG2011	ABC-type metal ion transport system permease component
LH59_04205	COG1595	DNA-templated transcription, initiation
LH59_04210	COG3712	iron ion homeostasis
LH59_04230	COG0840	transmembrane signaling receptor activity
LH59_04235	COG0583	DNA-binding transcription factor activity
LH59_04245	COG0735	belongs to the Fur family
LH59_04275	COG1368	sulfuric ester hydrolase activity
LH59_04280	COG2982	Protein involved in outer membrane biogenesis
LH59_04295	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_04335	COG2154	pterin-4-alpha-carbinolamine dehydratase
LH59_04350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH59_04365	COG3178	'Phosphotransferase
LH59_04370	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LH59_04375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH59_04380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LH59_04385	COG1929	Belongs to the glycerate kinase type-1 family
LH59_04390	COG0469	pyruvate kinase activity
LH59_04395	COG0700	Nucleoside recognition
LH59_04400	COG1960	acyl-CoA dehydrogenase activity
LH59_04405	COG0242	peptide deformylase activity
LH59_04425	COG0204	Acyl-transferase
LH59_04430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LH59_04435	COG0751	glycine-tRNA ligase activity
LH59_04440	COG0752	glycyl-tRNA synthetase alpha subunit
LH59_04445	COG1024	Enoyl-CoA hydratase
LH59_04465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_04470	COG2030	dehydratase
LH59_04475	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_04490	COG2070	2-Nitropropane dioxygenase
LH59_04500	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_04505	COG0183	Belongs to the thiolase family
LH59_04515	COG1960	acyl-CoA dehydrogenase activity
LH59_04525	COG1024	Enoyl-CoA hydratase
LH59_04535	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
LH59_04545	COG2301	Belongs to the HpcH HpaI aldolase family
LH59_04550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH59_04560	COG0617	tRNA 3'-terminal CCA addition
LH59_04575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LH59_04585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LH59_04590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LH59_04595	COG0586	Pfam SNARE associated Golgi protein
LH59_04605	COG0860	N-Acetylmuramoyl-L-alanine amidase
LH59_04610	COG0114	fumarate hydratase activity
LH59_04620	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_04635	COG0531	amino acid
LH59_04640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_04650	COG1960	acyl-CoA dehydrogenase activity
LH59_04655	COG0583	DNA-binding transcription factor activity
LH59_04660	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH59_04690	COG0583	DNA-binding transcription factor activity
LH59_04700	COG0579	oxidoreductase
LH59_04710	COG0259	pyridoxamine-phosphate oxidase activity
LH59_04725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH59_04730	COG0577	efflux transmembrane transporter activity
LH59_04730	COG1136	(ABC) transporter
LH59_04735	COG1538	Outer membrane efflux protein
LH59_04740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LH59_04780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LH59_04790	COG0800	Aldolase
LH59_04810	COG1216	Glycosyl transferase, family 2
LH59_04810	COG0463	Glycosyl transferase, family 2
LH59_04815	COG0410	ABC transporter
LH59_04820	COG0411	ABC transporter
LH59_04835	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_04840	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LH59_04860	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LH59_04865	COG4638	Rieske (2fe-2S)
LH59_04890	COG0747	negative chemotaxis
LH59_04900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_04905	COG0444	Belongs to the ABC transporter superfamily
LH59_04910	COG4608	Belongs to the ABC transporter superfamily
LH59_04930	COG2746	aminoglycoside 3-N-acetyltransferase activity
LH59_04935	COG0488	(ABC) transporter
LH59_04955	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LH59_04960	COG2894	cell division
LH59_04965	COG0850	regulation of cytokinetic process
LH59_04970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH59_04980	COG1294	oxidase, subunit
LH59_04985	COG0514	ATP-dependent DNA helicase (RecQ)
LH59_04995	COG0745	RESPONSE REGULATOR receiver
LH59_05000	COG4191	Histidine kinase
LH59_05005	COG2255	four-way junction helicase activity
LH59_05015	COG1090	epimerase
LH59_05020	COG0632	four-way junction helicase activity
LH59_05045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH59_05055	COG0006	proline dipeptidase activity
LH59_05070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LH59_05075	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_05090	COG4783	chaperone-mediated protein folding
LH59_05130	COG2814	Major facilitator Superfamily
LH59_05135	COG4771	TonB-dependent receptor
LH59_05145	COG0513	Belongs to the DEAD box helicase family
LH59_05160	COG1058	Belongs to the CinA family
LH59_05160	COG1546	Belongs to the CinA family
LH59_05165	COG1414	Transcriptional regulator
LH59_05180	COG0167	dihydroorotate dehydrogenase activity
LH59_05185	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LH59_05190	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LH59_05265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LH59_05270	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH59_05275	COG0735	belongs to the Fur family
LH59_05280	COG0497	DNA recombination
LH59_05285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LH59_05290	COG1420	regulation of RNA biosynthetic process
LH59_05295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LH59_05305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LH59_05315	COG0443	Heat shock 70 kDa protein
LH59_05320	COG0484	heat shock protein binding
LH59_05330	COG0612	Peptidase, M16
LH59_05355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LH59_05390	COG0840	transmembrane signaling receptor activity
LH59_05395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_05410	COG0745	RESPONSE REGULATOR receiver
LH59_05415	COG2205	protein histidine kinase activity
LH59_05420	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LH59_05425	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LH59_05450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH59_05460	COG1193	negative regulation of DNA recombination
LH59_05465	COG0492	ferredoxin-NADP+ reductase activity
LH59_05470	COG1674	ftsk spoiiie
LH59_05475	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LH59_05480	COG0251	oxidation-reduction process
LH59_05485	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LH59_05490	COG0517	IMP dehydrogenase activity
LH59_05490	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LH59_05510	COG0601	transmembrane transport
LH59_05525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH59_05530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LH59_05535	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LH59_05565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_05575	COG4774	siderophore transport
LH59_05580	COG4607	ABC-type enterochelin transport system periplasmic component
LH59_05585	COG4604	ABC transporter, ATP-binding protein
LH59_05590	COG4605	iron ion homeostasis
LH59_05595	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_05625	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_05630	COG3022	response to hydroperoxide
LH59_05635	COG1289	transmembrane transporter activity
LH59_05640	COG0028	Belongs to the TPP enzyme family
LH59_05645	COG0440	acetolactate synthase activity
LH59_05650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LH59_05655	COG1183	phosphatidylcholine synthase activity
LH59_05665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LH59_05670	COG1185	polyribonucleotide nucleotidyltransferase activity
LH59_05680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LH59_05690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH59_05700	COG2207	Transcriptional regulator
LH59_05705	COG2814	Major facilitator Superfamily
LH59_05725	COG0149	triose-phosphate isomerase activity
LH59_05730	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH59_05770	COG0840	transmembrane signaling receptor activity
LH59_05790	COG1910	domain protein
LH59_05825	COG1116	anion transmembrane transporter activity
LH59_05840	COG1595	DNA-templated transcription, initiation
LH59_05845	COG3712	iron ion homeostasis
LH59_05865	COG0642	Histidine kinase
LH59_05875	COG2851	Citrate transporter
LH59_05880	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_05890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LH59_05895	COG3706	GGDEF domain
LH59_05895	COG0745	RESPONSE REGULATOR receiver
LH59_05900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LH59_05905	COG4191	Histidine kinase
LH59_05905	COG0784	Response regulator, receiver
LH59_05920	COG3604	Transcriptional regulator
LH59_05925	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
LH59_05930	COG3813	Protein conserved in bacteria
LH59_05935	COG2354	Protein conserved in bacteria
LH59_05940	COG4772	TonB-dependent receptor
LH59_05945	COG1522	sequence-specific DNA binding
LH59_05965	COG4172	Belongs to the ABC transporter superfamily
LH59_05975	COG0747	negative chemotaxis
LH59_05995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH59_06010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LH59_06015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH59_06020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH59_06040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH59_06050	COG1309	transcriptional regulator
LH59_06055	COG0583	DNA-binding transcription factor activity
LH59_06100	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_06105	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH59_06110	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH59_06115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH59_06120	COG0649	NAD binding
LH59_06125	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LH59_06135	COG1034	ATP synthesis coupled electron transport
LH59_06140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LH59_06145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH59_06155	COG0713	ATP synthesis coupled electron transport
LH59_06170	COG1007	ATP synthesis coupled electron transport
LH59_06180	COG4774	siderophore transport
LH59_06185	COG0560	Phosphoserine phosphatase
LH59_06190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LH59_06195	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LH59_06200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LH59_06210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH59_06215	COG0450	alkyl hydroperoxide reductase
LH59_06220	COG2205	protein histidine kinase activity
LH59_06225	COG0745	RESPONSE REGULATOR receiver
LH59_06230	COG1214	PFAM Peptidase M22, glycoprotease
LH59_06235	COG1573	uracil-dna glycosylase
LH59_06240	COG0477	Major facilitator Superfamily
LH59_06245	COG1196	nuclear chromosome segregation
LH59_06255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LH59_06260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH59_06270	COG2917	probably involved in intracellular septation
LH59_06275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH59_06280	COG1122	ATPase activity
LH59_06285	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LH59_06290	COG1268	BioY protein
LH59_06325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LH59_06355	COG0411	ABC transporter
LH59_06360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LH59_06365	COG2878	Part of a membrane complex involved in electron transport
LH59_06380	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LH59_06385	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LH59_06390	COG0251	oxidation-reduction process
LH59_06400	COG3228	Belongs to the MtfA family
LH59_06405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LH59_06415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH59_06420	COG0133	tryptophan synthase activity
LH59_06425	COG0159	tryptophan synthase activity
LH59_06430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LH59_06435	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LH59_06440	COG1530	ribonuclease E activity
LH59_06450	COG0546	phosphoglycolate phosphatase activity
LH59_06455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LH59_06460	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LH59_06475	COG0424	maF-like protein
LH59_06480	COG1399	metal-binding, possibly nucleic acid-binding protein
LH59_06485	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LH59_06490	COG0416	fatty acid biosynthetic process
LH59_06495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LH59_06500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LH59_06510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH59_06515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LH59_06540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH59_06545	COG0481	GTPase activity
LH59_06550	COG0681	Belongs to the peptidase S26 family
LH59_06555	COG0571	ribonuclease III activity
LH59_06560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LH59_06565	COG1381	Involved in DNA repair and RecF pathway recombination
LH59_06615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LH59_06640	COG0583	DNA-binding transcription factor activity
LH59_06650	COG0791	NLP P60 protein
LH59_06660	COG3193	protein, possibly involved in utilization of glycolate and propanediol
LH59_06680	COG0697	spore germination
LH59_06685	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LH59_06710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_06735	COG2153	protein acetylation
LH59_06745	COG1446	asparaginase
LH59_06750	COG4172	Belongs to the ABC transporter superfamily
LH59_06755	COG0747	negative chemotaxis
LH59_06790	COG0504	CTP synthase activity
LH59_06800	COG0148	phosphopyruvate hydratase activity
LH59_06815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LH59_06825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LH59_06880	COG0039	L-malate dehydrogenase activity
LH59_06885	COG2188	Transcriptional regulator
LH59_06890	COG2009	succinate dehydrogenase
LH59_06895	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LH59_06900	COG1053	succinate dehydrogenase
LH59_06905	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LH59_06910	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LH59_06915	COG0372	Belongs to the citrate synthase family
LH59_06930	COG0281	malic enzyme
LH59_06930	COG0280	phosphate acetyltransferase
LH59_06940	COG1297	OPT oligopeptide transporter protein
LH59_06945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH59_06960	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LH59_06965	COG1522	sequence-specific DNA binding
LH59_06970	COG0567	Dehydrogenase, E1 component
LH59_06980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH59_06985	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LH59_06990	COG1595	DNA-templated transcription, initiation
LH59_07025	COG0180	Tryptophanyl-tRNA synthetase
LH59_07035	COG2183	response to ionizing radiation
LH59_07040	COG1199	ATP-dependent helicase activity
LH59_07050	COG0564	pseudouridine synthase activity
LH59_07060	COG3243	poly(R)-hydroxyalkanoic acid synthase
LH59_07065	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_07070	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
LH59_07095	COG2831	hemolysin activation secretion protein
LH59_07110	COG2823	Periplasmic or secreted lipoprotein
LH59_07120	COG3237	CsbD-like
LH59_07130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH59_07130	COG0189	ligase activity
LH59_07135	COG0189	ligase activity
LH59_07135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH59_07140	COG1132	(ABC) transporter
LH59_07155	COG2833	Protein of unknown function (DUF455)
LH59_07160	COG2258	MOSC domain
LH59_07165	COG2951	lytic endotransglycosylase activity
LH59_07180	COG1960	acyl-CoA dehydrogenase activity
LH59_07190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LH59_07200	COG1696	Membrane protein involved in D-alanine export
LH59_07220	COG1215	transferase activity, transferring glycosyl groups
LH59_07230	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LH59_07250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LH59_07265	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LH59_07285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LH59_07290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LH59_07310	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LH59_07320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_07350	COG2951	lytic endotransglycosylase activity
LH59_07355	COG0123	including yeast histone deacetylase and acetoin utilization protein
LH59_07380	COG2985	domain, Protein
LH59_07385	COG1960	acyl-CoA dehydrogenase activity
LH59_07390	COG0450	alkyl hydroperoxide reductase
LH59_07400	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LH59_07405	COG4208	sulfate ABC transporter
LH59_07415	COG0175	sulfate reduction
LH59_07445	COG0335	large ribosomal subunit rRNA binding
LH59_07455	COG1162	GTPase activity
LH59_07460	COG0501	Belongs to the peptidase M48B family
LH59_07465	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LH59_07470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LH59_07475	COG3327	negative regulation of DNA-templated transcription, initiation
LH59_07480	COG3396	Phenylacetate-CoA oxygenase
LH59_07485	COG3460	Phenylacetate-CoA oxygenase
LH59_07490	COG3396	Phenylacetate-CoA oxygenase
LH59_07495	COG2151	metal-sulfur cluster biosynthetic enzyme
LH59_07500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LH59_07505	COG1012	belongs to the aldehyde dehydrogenase family
LH59_07510	COG1024	Enoyl-CoA hydratase
LH59_07515	COG2050	protein possibly involved in aromatic compounds catabolism
LH59_07525	COG0534	Mate efflux family protein
LH59_07535	COG0254	rRNA binding
LH59_07540	COG3483	tryptophan 2,3-dioxygenase activity
LH59_07545	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LH59_07550	COG2003	Belongs to the UPF0758 family
LH59_07565	COG0625	glutathione transferase activity
LH59_07570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH59_07580	COG0745	RESPONSE REGULATOR receiver
LH59_07595	COG0523	cobalamin synthesis protein
LH59_07600	COG0523	cobalamin synthesis protein
LH59_07605	COG0583	DNA-binding transcription factor activity
LH59_07615	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LH59_07620	COG1187	pseudouridine synthase activity
LH59_07625	COG0779	Required for maturation of 30S ribosomal subunits
LH59_07630	COG0195	Participates in both transcription termination and antitermination
LH59_07630	COG2251	uridine kinase activity
LH59_07635	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LH59_07640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LH59_07645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LH59_07670	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_07675	COG1473	amidohydrolase
LH59_07680	COG1611	Belongs to the LOG family
LH59_07695	COG0412	Dienelactone hydrolase
LH59_07705	COG1283	sodium-dependent phosphate transmembrane transporter activity
LH59_07710	COG1760	l-serine dehydratase
LH59_07715	COG0501	Belongs to the peptidase M48B family
LH59_07735	COG0583	DNA-binding transcription factor activity
LH59_07740	COG3842	ATPase activity
LH59_07750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH59_07755	COG1840	ABC-type Fe3 transport system, periplasmic component
LH59_07775	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_07785	COG1722	exodeoxyribonuclease VII activity
LH59_07790	COG0142	geranyltranstransferase activity
LH59_07795	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LH59_07800	COG1469	GTP cyclohydrolase I activity
LH59_07805	COG3739	integral membrane protein
LH59_07810	COG0360	Binds together with S18 to 16S ribosomal RNA
LH59_07815	COG2965	DNA replication, synthesis of RNA primer
LH59_07820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LH59_07825	COG0359	binds to the 23S rRNA
LH59_07835	COG0305	Participates in initiation and elongation during chromosome replication
LH59_07845	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LH59_07880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_07930	COG0540	Belongs to the ATCase OTCase family
LH59_07955	COG0642	Histidine kinase
LH59_07965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LH59_07970	COG2137	regulation of response to DNA damage stimulus
LH59_07975	COG0583	DNA-binding transcription factor activity
LH59_07980	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LH59_07995	COG0045	succinate-CoA ligase (ADP-forming) activity
LH59_08000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LH59_08005	COG0861	Integral membrane protein TerC family
LH59_08010	COG0861	Integral membrane protein TerC family
LH59_08020	COG0181	hydroxymethylbilane synthase activity
LH59_08040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LH59_08050	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_08070	COG0411	ABC transporter
LH59_08080	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_08100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LH59_08105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LH59_08115	COG0436	Aminotransferase
LH59_08135	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LH59_08140	COG0308	aminopeptidase N
LH59_08155	COG0312	modulator of DNA gyrase
LH59_08160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LH59_08165	COG0277	FAD linked oxidase domain protein
LH59_08170	COG0277	FAD linked oxidase domain protein
LH59_08175	COG0277	FAD linked oxidase domain protein
LH59_08180	COG0247	lactate metabolic process
LH59_08185	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LH59_08190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LH59_08195	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LH59_08210	COG0583	DNA-binding transcription factor activity
LH59_08215	COG0482	sulfurtransferase activity
LH59_08220	COG0730	response to heat
LH59_08225	COG0625	glutathione transferase activity
LH59_08235	COG3909	cytochrome
LH59_08275	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LH59_08395	COG0697	spore germination
LH59_08430	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LH59_08440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH59_08445	COG0069	glutamate synthase activity
LH59_08450	COG2391	methyltransferase activity
LH59_08455	COG0679	Auxin Efflux Carrier
LH59_08465	COG2153	protein acetylation
LH59_08485	COG0557	exoribonuclease II activity
LH59_08490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH59_08500	COG3128	pkhd-type hydroxylase
LH59_08505	COG0776	regulation of translation
LH59_08530	COG0745	RESPONSE REGULATOR receiver
LH59_08535	COG0642	Histidine kinase
LH59_08540	COG3158	transport of potassium into the cell
LH59_08545	COG0137	argininosuccinate synthase activity
LH59_08560	COG3618	amidohydrolase
LH59_08580	COG0596	Alpha beta hydrolase
LH59_08580	COG2945	thiolester hydrolase activity
LH59_08585	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LH59_08590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LH59_08610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_08615	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LH59_08625	COG3642	lipopolysaccharide core region biosynthetic process
LH59_08635	COG3842	ATPase activity
LH59_08640	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH59_08645	COG1177	transmembrane transport
LH59_08665	COG1322	Protein conserved in bacteria
LH59_08675	COG1960	acyl-CoA dehydrogenase activity
LH59_08685	COG0704	Plays a role in the regulation of phosphate uptake
LH59_08695	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LH59_08700	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LH59_08700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LH59_08705	COG1643	Atp-dependent helicase
LH59_08710	COG0395	ABC-type sugar transport system, permease component
LH59_08715	COG1116	anion transmembrane transporter activity
LH59_08730	COG0438	transferase activity, transferring glycosyl groups
LH59_08735	COG0726	polysaccharide deacetylase
LH59_08750	COG0726	polysaccharide deacetylase
LH59_08775	COG1132	(ABC) transporter
LH59_08780	COG0475	glutathione-regulated potassium exporter activity
LH59_08780	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH59_08790	COG5001	Diguanylate cyclase
LH59_08790	COG4251	negative regulation of phosphorylation
LH59_08790	COG3706	GGDEF domain
LH59_08790	COG2203	Gaf domain
LH59_08800	COG1530	ribonuclease E activity
LH59_08830	COG2204	response regulator
LH59_08835	COG4191	Histidine kinase
LH59_08840	COG1301	dicarboxylic acid transport
LH59_08845	COG0424	maF-like protein
LH59_08850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LH59_08855	COG0799	negative regulation of ribosome biogenesis
LH59_08860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LH59_08865	COG0408	coproporphyrinogen oxidase activity
LH59_08870	COG0151	Belongs to the GarS family
LH59_08875	COG0217	transcriptional regulatory protein
LH59_08880	COG0433	COG0433 Predicted ATPase
LH59_08885	COG0473	3-isopropylmalate dehydrogenase activity
LH59_08895	COG2814	Major facilitator Superfamily
LH59_08900	COG1566	PFAM secretion protein HlyD family protein
LH59_08910	COG1846	Transcriptional regulator
LH59_08940	COG3391	amine dehydrogenase activity
LH59_08950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LH59_08970	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LH59_08975	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LH59_08985	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LH59_08995	COG0187	DNA topoisomerase II activity
LH59_09010	COG1309	transcriptional regulator
LH59_09015	COG2311	Membrane
LH59_09020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LH59_09040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LH59_09045	COG0662	Cupin 2, conserved barrel domain protein
LH59_09050	COG5285	phytanoyl-CoA dioxygenase
LH59_09055	COG0633	Ferredoxin
LH59_09055	COG3217	Mosc domain protein beta barrel domain protein
LH59_09060	COG2076	Multidrug Resistance protein
LH59_09065	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LH59_09075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_09090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LH59_09095	COG0425	Belongs to the sulfur carrier protein TusA family
LH59_09105	COG0228	four-way junction DNA binding
LH59_09110	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LH59_09115	COG0336	Belongs to the RNA methyltransferase TrmD family
LH59_09120	COG1396	sequence-specific DNA binding
LH59_09125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_09130	COG0765	amino acid transport
LH59_09140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_09145	COG0525	valine-tRNA ligase activity
LH59_09150	COG0105	UTP biosynthetic process
LH59_09155	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LH59_09165	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LH59_09170	COG0124	histidyl-tRNA synthetase
LH59_09175	COG2976	Protein conserved in bacteria
LH59_09180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH59_09185	COG1160	GTP binding
LH59_09190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LH59_09195	COG1923	regulation of RNA biosynthetic process
LH59_09200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LH59_09205	COG0330	HflC and HflK could
LH59_09210	COG0330	HflC and HflK could
LH59_09215	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LH59_09225	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LH59_09230	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LH59_09250	COG0438	transferase activity, transferring glycosyl groups
LH59_09260	COG2755	lipolytic protein G-D-S-L family
LH59_09260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH59_09290	COG4964	Belongs to the GSP D family
LH59_09320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LH59_09330	COG1295	ribonuclease BN
LH59_09340	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LH59_09365	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LH59_09370	COG4783	chaperone-mediated protein folding
LH59_09400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH59_09405	COG2274	protein secretion by the type I secretion system
LH59_09415	COG1538	Outer membrane efflux protein
LH59_09420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LH59_09425	COG0066	3-isopropylmalate dehydratase activity
LH59_09430	COG0473	3-isopropylmalate dehydrogenase activity
LH59_09435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LH59_09445	COG0101	tRNA pseudouridine synthase activity
LH59_09450	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LH59_09470	COG0596	Alpha beta hydrolase
LH59_09505	COG0129	dihydroxy-acid dehydratase activity
LH59_09510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_09515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LH59_09520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LH59_09525	COG1609	Transcriptional regulator
LH59_09550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_09555	COG0601	transmembrane transport
LH59_09565	COG1012	belongs to the aldehyde dehydrogenase family
LH59_09595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH59_09600	COG2197	response regulator
LH59_09610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LH59_09615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LH59_09620	COG0189	ligase activity
LH59_09630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH59_09635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LH59_09640	COG0004	ammonium transporteR
LH59_09645	COG0347	Belongs to the P(II) protein family
LH59_09655	COG2960	long-chain fatty acid transporting porin activity
LH59_09670	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LH59_09675	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LH59_09680	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LH59_09685	COG0072	phenylalanine-tRNA ligase activity
LH59_09685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH59_09690	COG0776	regulation of translation
LH59_09740	COG0384	phenazine biosynthesis protein PhzF
LH59_09745	COG0456	acetyltransferase
LH59_09780	COG1522	sequence-specific DNA binding
LH59_09810	COG0583	DNA-binding transcription factor activity
LH59_09815	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_09840	COG1116	anion transmembrane transporter activity
LH59_09870	COG5265	(ABC) transporter
LH59_09875	COG0656	L-ascorbic acid biosynthetic process
LH59_09890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LH59_09900	COG4977	sequence-specific DNA binding
LH59_09900	COG1917	Cupin 2, conserved barrel domain protein
LH59_09905	COG2223	nitrite transmembrane transporter activity
LH59_09915	COG1215	transferase activity, transferring glycosyl groups
LH59_09920	COG0726	polysaccharide deacetylase
LH59_09920	COG1649	PFAM Uncharacterised BCR, COG1649
LH59_09935	COG3706	GGDEF domain
LH59_09960	COG1610	YqeY-like protein
LH59_09965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LH59_09970	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_10010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH59_10020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH59_10025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH59_10045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LH59_10045	COG1017	nitric oxide dioxygenase activity
LH59_10050	COG1959	2 iron, 2 sulfur cluster binding
LH59_10055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_10060	COG0697	spore germination
LH59_10065	COG0506	proline dehydrogenase activity
LH59_10085	COG0583	DNA-binding transcription factor activity
LH59_10095	COG0625	glutathione transferase activity
LH59_10115	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LH59_10130	COG1960	acyl-CoA dehydrogenase activity
LH59_10135	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_10175	COG3245	cytochrome
LH59_10180	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LH59_10195	COG1280	lysine exporter protein (LysE YggA)
LH59_10210	COG0697	spore germination
LH59_10215	COG0697	spore germination
LH59_10230	COG0534	Mate efflux family protein
LH59_10235	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LH59_10240	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_10250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LH59_10255	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LH59_10265	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_10300	COG2207	Transcriptional regulator
LH59_10315	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_10320	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_10325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH59_10330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LH59_10340	COG1304	FMN binding
LH59_10360	COG3712	iron ion homeostasis
LH59_10365	COG1595	DNA-templated transcription, initiation
LH59_10400	COG3088	subunit of a heme lyase
LH59_10415	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LH59_10435	COG4133	protoheme IX ABC transporter activity
LH59_10475	COG4235	cytochrome complex assembly
LH59_10485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH59_10495	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LH59_10515	COG4133	protoheme IX ABC transporter activity
LH59_10520	COG3005	denitrification pathway
LH59_10525	COG3043	anaerobic respiration
LH59_10545	COG3246	L-lysine catabolic process to acetate
LH59_10550	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_10555	COG0583	DNA-binding transcription factor activity
LH59_10565	COG0129	dihydroxy-acid dehydratase activity
LH59_10570	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_10575	COG5001	Diguanylate cyclase
LH59_10580	COG1024	Enoyl-CoA hydratase
LH59_10610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_10620	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
LH59_10625	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_10630	COG0583	DNA-binding transcription factor activity
LH59_10635	COG2610	gluconate transmembrane transporter activity
LH59_10675	COG0235	Class ii aldolase
LH59_10700	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_10740	COG1280	lysine exporter protein (LysE YggA)
LH59_10745	COG5265	(ABC) transporter
LH59_10755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_10770	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_10775	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_10810	COG0583	DNA-binding transcription factor activity
LH59_10820	COG0583	DNA-binding transcription factor activity
LH59_10830	COG0583	DNA-binding transcription factor activity
LH59_10855	COG2226	methyltransferase
LH59_10865	COG2814	Major facilitator Superfamily
LH59_10870	COG0154	amidase activity
LH59_10910	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_10915	COG2186	Transcriptional regulator
LH59_10920	COG1012	belongs to the aldehyde dehydrogenase family
LH59_10925	COG0307	riboflavin synthase, alpha
LH59_10935	COG2271	Major facilitator Superfamily
LH59_10945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH59_10955	COG0789	Transcriptional regulator
LH59_10980	COG4774	siderophore transport
LH59_10995	COG0022	dehydrogenase e1 component
LH59_11015	COG0165	Argininosuccinate lyase
LH59_11020	COG0668	transmembrane transport
LH59_11090	COG2165	general secretion pathway protein
LH59_11130	COG0583	DNA-binding transcription factor activity
LH59_11140	COG0747	negative chemotaxis
LH59_11145	COG0601	transmembrane transport
LH59_11155	COG4172	Belongs to the ABC transporter superfamily
LH59_11160	COG4681	YaeQ
LH59_11175	COG0477	Major facilitator Superfamily
LH59_11180	COG3161	chorismate lyase activity
LH59_11185	COG1187	pseudouridine synthase activity
LH59_11190	COG0583	DNA-binding transcription factor activity
LH59_11205	COG1538	Outer membrane efflux protein
LH59_11215	COG1999	signal sequence binding
LH59_11225	COG0339	signal peptide processing
LH59_11235	COG4566	intracellular signal transduction
LH59_11245	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LH59_11250	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH59_11255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH59_11265	COG0583	DNA-binding transcription factor activity
LH59_11290	COG1191	sigma factor activity
LH59_11310	COG1360	Flagellar Motor Protein
LH59_11325	COG0835	chemotaxis
LH59_11330	COG0840	transmembrane signaling receptor activity
LH59_11335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LH59_11340	COG2201	protein-glutamate methylesterase activity
LH59_11345	COG0745	RESPONSE REGULATOR receiver
LH59_11350	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LH59_11355	COG0840	transmembrane signaling receptor activity
LH59_11385	COG2747	anti-sigma28 factor FlgM
LH59_11395	COG1815	bacterial-type flagellum-dependent cell motility
LH59_11400	COG1558	bacterial-type flagellum-dependent cell motility
LH59_11405	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LH59_11410	COG1749	Flagellar hook protein flgE
LH59_11415	COG4787	bacterial-type flagellum-dependent cell motility
LH59_11420	COG4786	Flagellar basal body rod
LH59_11425	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LH59_11430	COG1706	bacterial-type flagellum-dependent cell motility
LH59_11440	COG1256	bacterial-type flagellum assembly
LH59_11450	COG0840	transmembrane signaling receptor activity
LH59_11460	COG0840	transmembrane signaling receptor activity
LH59_11465	COG0840	transmembrane signaling receptor activity
LH59_11485	COG3190	flagellar
LH59_11500	COG1580	Controls the rotational direction of flagella during chemotaxis
LH59_11525	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LH59_11530	COG1766	The M ring may be actively involved in energy transduction
LH59_11535	COG1677	Flagellar hook-basal body complex protein FliE
LH59_11545	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LH59_11565	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LH59_11570	COG1334	flagellar protein FlaG
LH59_11575	COG1414	Transcriptional regulator
LH59_11585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_11590	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_11600	COG0285	dihydrofolate synthase activity
LH59_11620	COG1451	nucleotide metabolic process
LH59_11625	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LH59_11635	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LH59_11640	COG0024	Methionine aminopeptidase
LH59_11645	COG0052	Belongs to the universal ribosomal protein uS2 family
LH59_11650	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LH59_11655	COG0528	UMP kinase activity
LH59_11660	COG0233	cytoplasmic translational termination
LH59_11665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LH59_11675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LH59_11680	COG0750	zinc metalloprotease
LH59_11685	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH59_11690	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LH59_11695	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH59_11700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH59_11710	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH59_11715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LH59_11720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH59_11730	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LH59_11745	COG0519	Catalyzes the synthesis of GMP from XMP
LH59_11745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH59_11760	COG0745	RESPONSE REGULATOR receiver
LH59_11760	COG3706	GGDEF domain
LH59_11765	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LH59_11770	COG2867	negative regulation of translational initiation
LH59_11785	COG1024	Enoyl-CoA hydratase
LH59_11785	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_11810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LH59_11815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LH59_11820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LH59_11825	COG0084	hydrolase, TatD family'
LH59_11840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_11850	COG1126	abc transporter atp-binding protein
LH59_11855	COG0010	Belongs to the arginase family
LH59_11865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LH59_11875	COG0095	Lipoate-protein ligase
LH59_11890	COG0625	glutathione transferase activity
LH59_11900	COG1522	sequence-specific DNA binding
LH59_11905	COG0386	Belongs to the glutathione peroxidase family
LH59_11910	COG2814	Major facilitator Superfamily
LH59_11985	COG1902	pentaerythritol trinitrate reductase activity
LH59_12015	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LH59_12030	COG0842	Transport permease protein
LH59_12035	COG1131	(ABC) transporter
LH59_12050	COG2130	NADP-dependent
LH59_12075	COG3842	ATPase activity
LH59_12080	COG3842	ATPase activity
LH59_12090	COG0395	ABC-type sugar transport system, permease component
LH59_12140	COG0346	lactoylglutathione lyase activity
LH59_12145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_12165	COG3634	alkyl hydroperoxide reductase activity
LH59_12170	COG1959	2 iron, 2 sulfur cluster binding
LH59_12175	COG1960	acyl-CoA dehydrogenase activity
LH59_12210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_12215	COG0420	3'-5' exonuclease activity
LH59_12240	COG2111	Na H antiporter
LH59_12240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LH59_12245	COG1006	Multisubunit Na H antiporter MnhC subunit
LH59_12250	COG0651	ATP synthesis coupled electron transport
LH59_12255	COG1863	multisubunit Na H antiporter MnhE subunit
LH59_12260	COG2212	antiporter activity
LH59_12265	COG1320	monovalent cation:proton antiporter activity
LH59_12280	COG0590	tRNA wobble adenosine to inosine editing
LH59_12285	COG1619	proteins homologs of microcin C7 resistance protein MccF
LH59_12290	COG0488	(ABC) transporter
LH59_12295	COG2814	Major facilitator Superfamily
LH59_12325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH59_12330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH59_12340	COG2252	PERMEase
LH59_12345	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LH59_12350	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LH59_12355	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LH59_12360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LH59_12385	COG0583	DNA-binding transcription factor activity
LH59_12390	COG2814	Major facilitator Superfamily
LH59_12395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LH59_12400	COG0789	Transcriptional regulator
LH59_12415	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LH59_12415	COG0678	peroxiredoxin activity
LH59_12425	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LH59_12430	COG0584	glycerophosphoryl diester phosphodiesterase
LH59_12440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH59_12450	COG4181	ATPase activity
LH59_12460	COG1178	ABC-type Fe3 transport system permease component
LH59_12465	COG3842	ATPase activity
LH59_12470	COG0583	DNA-binding transcription factor activity
LH59_12475	COG0560	Phosphoserine phosphatase
LH59_12490	COG0583	DNA-binding transcription factor activity
LH59_12505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LH59_12520	COG0583	DNA-binding transcription factor activity
LH59_12525	COG4336	lyase activity
LH59_12535	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_12545	COG0411	ABC transporter
LH59_12555	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_12575	COG2816	NAD+ diphosphatase activity
LH59_12605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_12610	COG0765	amino acid transport
LH59_12615	COG1126	abc transporter atp-binding protein
LH59_12620	COG1335	isochorismatase
LH59_12630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LH59_12635	COG1758	RNA polymerase activity
LH59_12645	COG0194	GDP metabolic process
LH59_12650	COG3258	Cytochrome c
LH59_12655	COG2863	cytochrome
LH59_12660	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_12665	COG2831	hemolysin activation secretion protein
LH59_12675	COG0791	NLP P60 protein
LH59_12690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LH59_12695	COG0833	amino acid
LH59_12700	COG1561	YicC-like family, N-terminal region
LH59_12705	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LH59_12715	COG1960	acyl-CoA dehydrogenase activity
LH59_12720	COG0840	transmembrane signaling receptor activity
LH59_12730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LH59_12735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH59_12745	COG3852	Histidine kinase
LH59_12750	COG2204	response regulator
LH59_12755	COG0583	DNA-binding transcription factor activity
LH59_12760	COG1741	Belongs to the pirin family
LH59_12765	COG1741	Belongs to the pirin family
LH59_12770	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_12775	COG3842	ATPase activity
LH59_12780	COG4149	molybdate abc transporter
LH59_12785	COG1840	ABC-type Fe3 transport system, periplasmic component
LH59_12795	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_12805	COG0583	DNA-binding transcription factor activity
LH59_12815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LH59_12825	COG0783	Belongs to the Dps family
LH59_12835	COG0457	Tetratricopeptide repeat
LH59_12840	COG0438	transferase activity, transferring glycosyl groups
LH59_12870	COG3866	Pectate lyase
LH59_12885	COG0745	RESPONSE REGULATOR receiver
LH59_12890	COG2205	protein histidine kinase activity
LH59_12905	COG3842	ATPase activity
LH59_12910	COG0395	ABC-type sugar transport system, permease component
LH59_12915	COG1175	transmembrane transport
LH59_12920	COG1653	transport
LH59_12930	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LH59_12940	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_12955	COG0410	ABC transporter
LH59_12965	COG1794	racemase activity, acting on amino acids and derivatives
LH59_12970	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LH59_12980	COG0583	DNA-binding transcription factor activity
LH59_12985	COG0625	glutathione transferase activity
LH59_12990	COG2133	pyrroloquinoline quinone binding
LH59_13000	COG0697	spore germination
LH59_13005	COG2363	Small membrane protein
LH59_13025	COG0010	Belongs to the arginase family
LH59_13030	COG1464	Belongs to the NlpA lipoprotein family
LH59_13035	COG0745	RESPONSE REGULATOR receiver
LH59_13035	COG3706	GGDEF domain
LH59_13040	COG2814	Major facilitator Superfamily
LH59_13050	COG1408	metallophosphoesterase
LH59_13060	COG0688	phosphatidylethanolamine metabolic process
LH59_13065	COG0488	(ABC) transporter
LH59_13090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_13095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LH59_13100	COG5001	Diguanylate cyclase
LH59_13100	COG3300	MHYT domain
LH59_13140	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LH59_13145	COG2204	response regulator
LH59_13175	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_13195	COG0693	protein deglycase activity
LH59_13215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH59_13230	COG3300	MHYT domain
LH59_13230	COG5001	Diguanylate cyclase
LH59_13245	COG4774	siderophore transport
LH59_13285	COG1253	flavin adenine dinucleotide binding
LH59_13295	COG2205	protein histidine kinase activity
LH59_13470	COG3706	GGDEF domain
LH59_13475	COG0789	Transcriptional regulator
LH59_13485	COG3706	GGDEF domain
LH59_13515	COG1116	anion transmembrane transporter activity
LH59_13520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_13525	COG4521	taurine ABC transporter
LH59_13555	COG0793	Belongs to the peptidase S41A family
LH59_13575	COG0628	permease
LH59_13585	COG1619	proteins homologs of microcin C7 resistance protein MccF
LH59_13600	COG0531	amino acid
LH59_13610	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LH59_13615	COG4608	Belongs to the ABC transporter superfamily
LH59_13620	COG0444	Belongs to the ABC transporter superfamily
LH59_13630	COG0601	transmembrane transport
LH59_13635	COG0747	negative chemotaxis
LH59_13645	COG0251	oxidation-reduction process
LH59_13665	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH59_13680	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LH59_13695	COG0446	pyridine nucleotide-disulphide oxidoreductase
LH59_13705	COG3971	2-oxopent-4-enoate hydratase activity
LH59_13735	COG0625	glutathione transferase activity
LH59_13750	COG0477	Major facilitator Superfamily
LH59_13760	COG0579	oxidoreductase
LH59_13775	COG0625	glutathione transferase activity
LH59_13790	COG0431	NADPH-dependent FMN reductase
LH59_13800	COG0798	PFAM Bile acid sodium symporter
LH59_13810	COG0640	Transcriptional regulator
LH59_13825	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LH59_13845	COG1126	abc transporter atp-binding protein
LH59_13850	COG0765	amino acid transport
LH59_13855	COG4597	amino acid ABC transporter
LH59_13865	COG0626	cystathionine gamma-synthase activity
LH59_13870	COG0583	DNA-binding transcription factor activity
LH59_13900	COG0601	transmembrane transport
LH59_13905	COG0747	negative chemotaxis
LH59_13915	COG0583	DNA-binding transcription factor activity
LH59_13920	COG1335	isochorismatase
LH59_13925	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH59_13940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_13945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_13960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH59_13960	COG0519	Catalyzes the synthesis of GMP from XMP
LH59_13970	COG1276	copper resistance
LH59_13990	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_13995	COG3386	PFAM SMP-30 Gluconolaconase
LH59_14000	COG2721	sulfolactate sulfo-lyase activity
LH59_14020	COG0745	RESPONSE REGULATOR receiver
LH59_14030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_14035	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LH59_14040	COG3842	ATPase activity
LH59_14045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LH59_14060	COG0586	Pfam SNARE associated Golgi protein
LH59_14065	COG0390	transport system, permease component
LH59_14120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_14125	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_14130	COG1120	ATPase activity
LH59_14135	COG1126	abc transporter atp-binding protein
LH59_14140	COG0765	amino acid transport
LH59_14150	COG2070	2-Nitropropane dioxygenase
LH59_14155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH59_14165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LH59_14190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LH59_14195	COG0583	DNA-binding transcription factor activity
LH59_14205	COG1846	Transcriptional regulator
LH59_14215	COG4191	Histidine kinase
LH59_14220	COG4566	intracellular signal transduction
LH59_14250	COG0583	DNA-binding transcription factor activity
LH59_14280	COG0765	amino acid transport
LH59_14310	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LH59_14335	COG0251	oxidation-reduction process
LH59_14375	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_14385	COG1802	Transcriptional regulator
LH59_14390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_14405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LH59_14430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_14435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_14440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_14440	COG1116	anion transmembrane transporter activity
LH59_14475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_14480	COG4597	amino acid ABC transporter
LH59_14500	COG2197	response regulator
LH59_14505	COG3850	Histidine kinase
LH59_14510	COG1763	Mo-molybdopterin cofactor biosynthetic process
LH59_14515	COG0288	reversible hydration of carbon dioxide
LH59_14520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LH59_14525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH59_14530	COG2181	nitrate reductase activity
LH59_14535	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
LH59_14540	COG1140	nitrate reductase beta subunit
LH59_14545	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LH59_14550	COG2223	nitrite transmembrane transporter activity
LH59_14595	COG0583	DNA-binding transcription factor activity
LH59_14605	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_14635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_14655	COG2070	2-Nitropropane dioxygenase
LH59_14675	COG5002	protein histidine kinase activity
LH59_14680	COG0745	RESPONSE REGULATOR receiver
LH59_14690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LH59_14700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH59_14705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH59_14720	COG0783	Belongs to the Dps family
LH59_14750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_14755	COG0697	spore germination
LH59_14760	COG2879	small protein
LH59_14765	COG1966	Carbon starvation protein
LH59_14790	COG0583	DNA-binding transcription factor activity
LH59_14795	COG4521	taurine ABC transporter
LH59_14800	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LH59_14805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_14820	COG3712	iron ion homeostasis
LH59_14825	COG1595	DNA-templated transcription, initiation
LH59_14830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_14850	COG0235	Class ii aldolase
LH59_14855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_14865	COG0523	cobalamin synthesis protein
LH59_14870	COG1228	amidohydrolase
LH59_14875	COG4172	Belongs to the ABC transporter superfamily
LH59_14880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_14885	COG0601	transmembrane transport
LH59_14890	COG0747	negative chemotaxis
LH59_14905	COG1414	Transcriptional regulator
LH59_14910	COG0513	Belongs to the DEAD box helicase family
LH59_14915	COG0602	queuosine metabolic process
LH59_14920	COG0720	synthase
LH59_14930	COG1289	transmembrane transporter activity
LH59_14940	COG1566	PFAM secretion protein HlyD family protein
LH59_14955	COG0028	Belongs to the TPP enzyme family
LH59_14965	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_14975	COG0400	carboxylic ester hydrolase activity
LH59_14980	COG0833	amino acid
LH59_15000	COG0587	DNA-directed DNA polymerase activity
LH59_15010	COG0789	Transcriptional regulator
LH59_15020	COG0667	Aldo Keto reductase
LH59_15025	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_15030	COG0583	DNA-binding transcription factor activity
LH59_15040	COG3038	cytochrome b561
LH59_15060	COG0840	transmembrane signaling receptor activity
LH59_15125	COG2764	glyoxalase bleomycin resistance protein dioxygenase
LH59_15145	COG4774	siderophore transport
LH59_15150	COG2345	Transcriptional regulator
LH59_15160	COG1414	Transcriptional regulator
LH59_15170	COG0477	Major facilitator Superfamily
LH59_15175	COG0667	Aldo Keto reductase
LH59_15185	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_15190	COG1309	transcriptional regulator
LH59_15210	COG1683	Conserved Protein
LH59_15220	COG2207	Transcriptional regulator
LH59_15240	COG3047	cAMP biosynthetic process
LH59_15240	COG2885	chlorophyll binding
LH59_15255	COG3795	YCII-related domain
LH59_15260	COG3795	YCII-related domain
LH59_15270	COG4941	Belongs to the sigma-70 factor family
LH59_15280	COG0697	spore germination
LH59_15290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH59_15300	COG0583	DNA-binding transcription factor activity
LH59_15330	COG1846	Transcriptional regulator
LH59_15335	COG3541	Predicted nucleotidyltransferase
LH59_15355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_15385	COG1360	Flagellar Motor Protein
LH59_15395	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
LH59_15425	COG3501	Rhs element vgr protein
LH59_15575	COG0024	Methionine aminopeptidase
LH59_15585	COG0625	glutathione transferase activity
LH59_15590	COG2032	superoxide dismutase activity
LH59_15595	COG2733	membrane
LH59_15605	COG0148	phosphopyruvate hydratase activity
LH59_15630	COG0583	DNA-binding transcription factor activity
LH59_15640	COG0183	Belongs to the thiolase family
LH59_15645	COG1960	acyl-CoA dehydrogenase activity
LH59_15650	COG1960	acyl-CoA dehydrogenase activity
LH59_15655	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_15665	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LH59_15680	COG0583	DNA-binding transcription factor activity
LH59_15690	COG1846	Transcriptional regulator
LH59_15695	COG0477	Major facilitator Superfamily
LH59_15710	COG2080	2 iron, 2 sulfur cluster binding
LH59_15720	COG0596	Alpha beta hydrolase
LH59_15725	COG2309	aminopeptidase activity
LH59_15730	COG1335	isochorismatase
LH59_15735	COG2010	Cytochrome c
LH59_15735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LH59_15745	COG1522	sequence-specific DNA binding
LH59_15750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_15755	COG3842	ATPase activity
LH59_15760	COG1840	ABC-type Fe3 transport system, periplasmic component
LH59_15765	COG4149	molybdate abc transporter
LH59_15770	COG5001	Diguanylate cyclase
LH59_15770	COG4251	negative regulation of phosphorylation
LH59_15770	COG3706	GGDEF domain
LH59_15770	COG2203	Gaf domain
LH59_15775	COG2201	protein-glutamate methylesterase activity
LH59_15800	COG0840	transmembrane signaling receptor activity
LH59_15805	COG0154	amidase activity
LH59_15820	COG0583	DNA-binding transcription factor activity
LH59_15850	COG0456	acetyltransferase
LH59_15865	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_15895	COG0477	Major facilitator Superfamily
LH59_15925	COG0165	Argininosuccinate lyase
LH59_15965	COG2267	carboxylic ester hydrolase activity
LH59_15975	COG4221	oxidoreductase activity
LH59_15980	COG2207	Transcriptional regulator
LH59_16015	COG0640	Transcriptional regulator
LH59_16025	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LH59_16030	COG0583	DNA-binding transcription factor activity
LH59_16035	COG0431	NADPH-dependent FMN reductase
LH59_16045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LH59_16065	COG4264	IucA IucC family
LH59_16085	COG3328	transposase activity
LH59_16105	COG0519	Catalyzes the synthesis of GMP from XMP
LH59_16105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH59_16135	COG0583	DNA-binding transcription factor activity
LH59_16145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH59_16170	COG0583	DNA-binding transcription factor activity
LH59_16175	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_16215	COG2072	flavoprotein involved in K transport
LH59_16220	COG0601	transmembrane transport
LH59_16225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_16235	COG4608	Belongs to the ABC transporter superfamily
LH59_16240	COG0747	negative chemotaxis
LH59_16255	COG0583	DNA-binding transcription factor activity
LH59_16260	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_16265	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LH59_16270	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_16315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH59_16340	COG0583	DNA-binding transcription factor activity
LH59_16390	COG5001	Diguanylate cyclase
LH59_16395	COG4774	siderophore transport
LH59_16410	COG0583	DNA-binding transcription factor activity
LH59_16460	COG1953	Uracil, thiamine, allantoin
LH59_16495	COG0583	DNA-binding transcription factor activity
LH59_16500	COG2205	protein histidine kinase activity
LH59_16500	COG2198	Histidine kinase
LH59_16500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_16500	COG0784	Response regulator, receiver
LH59_16530	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_16535	COG0583	DNA-binding transcription factor activity
LH59_16540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_16550	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_16560	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LH59_16570	COG0583	DNA-binding transcription factor activity
LH59_16585	COG0642	Histidine kinase
LH59_16590	COG0745	RESPONSE REGULATOR receiver
LH59_16620	COG0047	phosphoribosylformylglycinamidine synthase activity
LH59_16620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LH59_16635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_16645	COG0613	PHP domain protein
LH59_16660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LH59_16670	COG0583	DNA-binding transcription factor activity
LH59_16680	COG0583	DNA-binding transcription factor activity
LH59_16685	COG0477	Major facilitator Superfamily
LH59_16690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH59_16700	COG0159	tryptophan synthase activity
LH59_16710	COG0583	DNA-binding transcription factor activity
LH59_16730	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_16780	COG2149	membrane
LH59_16790	COG3093	addiction module antidote protein HigA
LH59_16815	COG2249	NAD(P)H dehydrogenase (quinone) activity
LH59_16825	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LH59_16830	COG0459	protein refolding
LH59_16865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LH59_16870	COG0714	Associated with various cellular activities
LH59_16890	COG2304	oxidoreductase activity
LH59_16905	COG3119	arylsulfatase activity
LH59_16915	COG1280	lysine exporter protein (LysE YggA)
LH59_16945	COG0633	Ferredoxin
LH59_16950	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_16955	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_16960	COG4133	protoheme IX ABC transporter activity
LH59_16965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH59_17010	COG4604	ABC transporter, ATP-binding protein
LH59_17015	COG4605	iron ion homeostasis
LH59_17020	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_17025	COG4607	ABC-type enterochelin transport system periplasmic component
LH59_17030	COG4771	TonB-dependent receptor
LH59_17035	COG0745	RESPONSE REGULATOR receiver
LH59_17045	COG0084	hydrolase, TatD family'
LH59_17050	COG1136	(ABC) transporter
LH59_17070	COG2271	Major facilitator Superfamily
LH59_17075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LH59_17080	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_17085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LH59_17100	COG3135	benzoate transporter
LH59_17105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LH59_17110	COG1309	transcriptional regulator
LH59_17115	COG0183	Belongs to the thiolase family
LH59_17120	COG1022	Amp-dependent synthetase and ligase
LH59_17125	COG0410	ABC transporter
LH59_17145	COG1024	Enoyl-CoA hydratase
LH59_17155	COG1803	Methylglyoxal synthase
LH59_17160	COG2975	iron-sulfur cluster assembly
LH59_17165	COG0633	Ferredoxin
LH59_17170	COG0443	Heat shock 70 kDa protein
LH59_17175	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LH59_17180	COG0316	Belongs to the HesB IscA family
LH59_17185	COG0822	iron-sulfur transferase activity
LH59_17190	COG1104	cysteine desulfurase activity
LH59_17200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LH59_17205	COG0556	nucleotide-excision repair
LH59_17215	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LH59_17220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LH59_17225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LH59_17230	COG0740	serine-type endopeptidase activity
LH59_17235	COG0544	peptidyl-prolyl cis-trans isomerase activity
LH59_17240	COG0501	Belongs to the peptidase M48B family
LH59_17250	COG1278	Cold shock
LH59_17260	COG1278	Cold shock
LH59_17285	COG0251	oxidation-reduction process
LH59_17295	COG0583	DNA-binding transcription factor activity
LH59_17330	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LH59_17345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LH59_17355	COG0277	FAD linked oxidase domain protein
LH59_17365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LH59_17370	COG2814	Major facilitator Superfamily
LH59_17505	COG0740	serine-type endopeptidase activity
LH59_17605	COG2171	N-acyltransferase activity
LH59_17615	COG2890	protein-(glutamine-N5) methyltransferase activity
LH59_17620	COG0488	(ABC) transporter
LH59_17635	COG4771	TonB-dependent receptor
LH59_17640	COG4771	TonB-dependent receptor
LH59_17655	COG1858	cytochrome C peroxidase
LH59_17665	COG0210	DNA helicase
LH59_17680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LH59_17680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LH59_17690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LH59_17695	COG0196	riboflavin kinase activity
LH59_17700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LH59_17705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LH59_17710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LH59_17760	COG1902	pentaerythritol trinitrate reductase activity
LH59_17765	COG1126	abc transporter atp-binding protein
LH59_17770	COG0765	amino acid transport
LH59_17775	COG0765	amino acid transport
LH59_17780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_17790	COG2423	ornithine cyclodeaminase activity
LH59_17795	COG1764	response to oxidative stress
LH59_17805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH59_17810	COG0625	glutathione transferase activity
LH59_17830	COG2271	Major facilitator Superfamily
LH59_17840	COG0411	ABC transporter
LH59_17850	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_17860	COG0506	proline dehydrogenase activity
LH59_17860	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LH59_17860	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LH59_17870	COG3008	intermembrane lipid transfer
LH59_17875	COG2995	paraquat-inducible protein a
LH59_17885	COG4953	penicillin-binding protein 1C
LH59_17890	COG2373	Large extracellular alpha-helical protein
LH59_17895	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LH59_17900	COG1278	Cold shock
LH59_17910	COG0183	Belongs to the thiolase family
LH59_17915	COG0038	chloride channel
LH59_17925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LH59_17935	COG1570	exodeoxyribonuclease VII activity
LH59_17940	COG0811	peptide transport
LH59_17950	COG1663	tetraacyldisaccharide 4'-kinase activity
LH59_17960	COG2835	tetraacyldisaccharide 4'-kinase activity
LH59_17965	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LH59_17970	COG0563	adenylate kinase activity
LH59_17980	COG0728	peptidoglycan biosynthetic process
LH59_17990	COG0268	Binds directly to 16S ribosomal RNA
LH59_17995	COG0583	DNA-binding transcription factor activity
LH59_18000	COG0019	diaminopimelate decarboxylase activity
LH59_18010	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_18015	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LH59_18020	COG2186	Transcriptional regulator
LH59_18030	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_18040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH59_18075	COG3384	dioxygenase
LH59_18080	COG1012	belongs to the aldehyde dehydrogenase family
LH59_18095	COG3971	2-oxopent-4-enoate hydratase activity
LH59_18105	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_18110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LH59_18115	COG1562	ergosterol biosynthetic process
LH59_18120	COG1562	ergosterol biosynthetic process
LH59_18130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LH59_18160	COG5564	TIM-barrel signal transduction protein
LH59_18165	COG5441	Belongs to the UPF0261 family
LH59_18190	COG0542	response to heat
LH59_18200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH59_18210	COG0477	Major facilitator Superfamily
LH59_18225	COG0494	nUDIX hydrolase
LH59_18230	COG0583	DNA-binding transcription factor activity
LH59_18235	COG0443	Heat shock 70 kDa protein
LH59_18270	COG2814	Major facilitator Superfamily
LH59_18280	COG3530	Putative quorum-sensing-regulated virulence factor
LH59_18295	COG0625	glutathione transferase activity
LH59_18320	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_18330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH59_18390	COG1522	sequence-specific DNA binding
LH59_18400	COG4172	Belongs to the ABC transporter superfamily
LH59_18425	COG0519	Catalyzes the synthesis of GMP from XMP
LH59_18430	COG0519	Catalyzes the synthesis of GMP from XMP
LH59_18455	COG0583	DNA-binding transcription factor activity
LH59_18460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LH59_18465	COG2272	Belongs to the type-B carboxylesterase lipase family
LH59_18470	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_18475	COG1309	transcriptional regulator
LH59_18485	COG1473	amidohydrolase
LH59_18500	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
LH59_18520	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_18555	COG2011	ABC-type metal ion transport system permease component
LH59_18560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LH59_18565	COG1464	Belongs to the NlpA lipoprotein family
LH59_18575	COG2814	Major facilitator Superfamily
LH59_18585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LH59_18590	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_18630	COG2837	iron assimilation
LH59_18695	COG0583	DNA-binding transcription factor activity
LH59_18700	COG2814	Major facilitator Superfamily
LH59_18705	COG2169	Transcriptional regulator
LH59_18735	COG1272	protein, Hemolysin III
LH59_18745	COG1278	Cold shock
LH59_18775	COG4638	Rieske (2fe-2S)
LH59_18790	COG0604	alcohol dehydrogenase
LH59_18790	COG3321	synthase
LH59_18805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_18830	COG0183	Belongs to the thiolase family
LH59_18845	COG0842	Transport permease protein
LH59_18850	COG1131	(ABC) transporter
LH59_18860	COG2197	response regulator
LH59_18865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_18865	COG1116	anion transmembrane transporter activity
LH59_18870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_18875	COG1116	anion transmembrane transporter activity
LH59_18880	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
LH59_18885	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LH59_18900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH59_18990	COG1396	sequence-specific DNA binding
LH59_18995	COG0235	Class ii aldolase
LH59_19005	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_19040	COG0045	succinate-CoA ligase (ADP-forming) activity
LH59_19040	COG1042	CoA-binding domain protein
LH59_19040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH59_19045	COG1024	Enoyl-CoA hydratase
LH59_19060	COG0583	DNA-binding transcription factor activity
LH59_19120	COG3384	dioxygenase
LH59_19150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LH59_19155	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LH59_19160	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LH59_19170	COG1609	Transcriptional regulator
LH59_19180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_19185	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LH59_19195	COG1850	ribulose-bisphosphate carboxylase activity
LH59_19210	COG0505	Belongs to the CarA family
LH59_19225	COG1982	Orn Lys Arg decarboxylase major
LH59_19235	COG3608	succinylglutamate desuccinylase aspartoacylase
LH59_19235	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LH59_19240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LH59_19260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_19360	COG0387	Pfam Sodium calcium exchanger
LH59_19365	COG3568	Endonuclease Exonuclease Phosphatase
LH59_19370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH59_19375	COG0392	lysyltransferase activity
LH59_19385	COG0366	Alpha amylase catalytic
LH59_19390	COG0366	Alpha amylase catalytic
LH59_19405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LH59_19410	COG1640	4-alpha-glucanotransferase
LH59_19420	COG1113	amino acid transport
LH59_19435	COG1546	Belongs to the CinA family
LH59_19435	COG1058	Belongs to the CinA family
LH59_19445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH59_19455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LH59_19465	COG0477	Major facilitator Superfamily
LH59_19505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH59_19540	COG1414	Transcriptional regulator
LH59_19545	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH59_19550	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_19560	COG2721	sulfolactate sulfo-lyase activity
LH59_19570	COG0765	amino acid transport
LH59_19585	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_19595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LH59_19600	COG3958	Transketolase
LH59_19605	COG3959	Transketolase, thiamine diphosphate binding domain
LH59_19610	COG1802	Transcriptional regulator
LH59_19615	COG0371	Dehydrogenase
LH59_19620	COG3246	L-lysine catabolic process to acetate
LH59_19625	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_19630	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_19640	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_19650	COG0410	ABC transporter
LH59_19655	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_19655	COG0604	alcohol dehydrogenase
LH59_19655	COG3321	synthase
LH59_19660	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_19690	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_19695	COG0583	DNA-binding transcription factor activity
LH59_19700	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LH59_19705	COG2885	chlorophyll binding
LH59_19705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LH59_19725	COG2814	Major facilitator Superfamily
LH59_19740	COG3384	dioxygenase
LH59_19755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LH59_19810	COG4964	Belongs to the GSP D family
LH59_19855	COG1846	Transcriptional regulator
LH59_19860	COG4172	Belongs to the ABC transporter superfamily
LH59_19865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_19870	COG0601	transmembrane transport
LH59_19885	COG0598	Magnesium transport protein CorA
LH59_19890	COG0210	DNA helicase
LH59_19905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LH59_19920	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LH59_19925	COG1045	serine acetyltransferase
LH59_19930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LH59_19935	COG0166	Belongs to the GPI family
LH59_19940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH59_19945	COG0489	protein tyrosine kinase activity
LH59_19945	COG3206	protein involved in exopolysaccharide biosynthesis
LH59_19960	COG1051	belongs to the nudix hydrolase family
LH59_19980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_20010	COG0463	Glycosyl transferase, family 2
LH59_20015	COG0110	maltose O-acetyltransferase activity
LH59_20020	COG0297	glycogen (starch) synthase activity
LH59_20025	COG2197	response regulator
LH59_20030	COG2197	response regulator
LH59_20040	COG1309	transcriptional regulator
LH59_20045	COG1960	acyl-CoA dehydrogenase activity
LH59_20055	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_20055	COG1024	Enoyl-CoA hydratase
LH59_20065	COG1024	Enoyl-CoA hydratase
LH59_20065	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_20070	COG0183	Belongs to the thiolase family
LH59_20085	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_20095	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_20105	COG1132	(ABC) transporter
LH59_20115	COG3395	kinase activity
LH59_20120	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LH59_20135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LH59_20140	COG1024	Enoyl-CoA hydratase
LH59_20150	COG1414	Transcriptional regulator
LH59_20160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LH59_20180	COG0583	DNA-binding transcription factor activity
LH59_20200	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LH59_20205	COG1309	transcriptional regulator
LH59_20215	COG1051	belongs to the nudix hydrolase family
LH59_20220	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LH59_20235	COG0784	Response regulator, receiver
LH59_20235	COG2205	protein histidine kinase activity
LH59_20245	COG0784	Response regulator, receiver
LH59_20245	COG2205	protein histidine kinase activity
LH59_20260	COG2863	cytochrome
LH59_20270	COG3278	Belongs to the heme-copper respiratory oxidase family
LH59_20300	COG0527	aspartate kinase activity
LH59_20305	COG0037	tRNA processing
LH59_20310	COG0825	malonyl-CoA metabolic process
LH59_20320	COG0215	cysteine-tRNA ligase activity
LH59_20340	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH59_20345	COG1968	undecaprenyl-diphosphatase activity
LH59_20350	COG1253	flavin adenine dinucleotide binding
LH59_20365	COG4263	nitrous-oxide reductase activity
LH59_20380	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LH59_20390	COG1477	protein flavinylation
LH59_20395	COG4804	nuclease activity
LH59_20420	COG0668	transmembrane transport
LH59_20460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_20465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_20470	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LH59_20505	COG3360	Dodecin
LH59_20515	COG0583	DNA-binding transcription factor activity
LH59_20520	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_20580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LH59_20585	COG2850	peptidyl-arginine hydroxylation
LH59_20600	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LH59_20605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_20610	COG1994	Peptidase M50
LH59_20615	COG0009	L-threonylcarbamoyladenylate synthase
LH59_20620	COG2321	neutral zinc metallopeptidase
LH59_20680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH59_20685	COG3969	phosphoadenosine phosphosulfate
LH59_20690	COG1475	DNA binding
LH59_20695	COG0642	Histidine kinase
LH59_20700	COG0745	RESPONSE REGULATOR receiver
LH59_20715	COG3188	usher protein
LH59_20720	COG3121	Chaperone
LH59_20760	COG3387	PFAM Glycoside hydrolase 15-related
LH59_20775	COG0840	transmembrane signaling receptor activity
LH59_20780	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_20785	COG1280	lysine exporter protein (LysE YggA)
LH59_20800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH59_20820	COG2084	Dehydrogenase
LH59_20845	COG1595	DNA-templated transcription, initiation
LH59_20860	COG1802	Transcriptional regulator
LH59_20875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH59_20895	COG0745	RESPONSE REGULATOR receiver
LH59_20900	COG2205	protein histidine kinase activity
LH59_20905	COG1764	response to oxidative stress
LH59_20910	COG0583	DNA-binding transcription factor activity
LH59_20915	COG0601	transmembrane transport
LH59_20920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_20925	COG0444	Belongs to the ABC transporter superfamily
LH59_20930	COG4608	Belongs to the ABC transporter superfamily
LH59_20945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_20950	COG0586	Pfam SNARE associated Golgi protein
LH59_20955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_20960	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LH59_21015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_21020	COG0765	amino acid transport
LH59_21040	COG1012	belongs to the aldehyde dehydrogenase family
LH59_21085	COG0348	domain, Protein
LH59_21105	COG3278	Belongs to the heme-copper respiratory oxidase family
LH59_21120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LH59_21125	COG0156	8-amino-7-oxononanoate synthase activity
LH59_21135	COG4106	trans-aconitate 2-methyltransferase activity
LH59_21135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LH59_21155	COG2224	Isocitrate lyase
LH59_21160	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LH59_21160	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LH59_21165	COG1858	cytochrome C peroxidase
LH59_21170	COG0583	DNA-binding transcription factor activity
LH59_21175	COG0473	3-isopropylmalate dehydrogenase activity
LH59_21185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LH59_21190	COG0322	excinuclease ABC activity
LH59_21195	COG1472	Belongs to the glycosyl hydrolase 3 family
LH59_21200	COG0736	holo-[acyl-carrier-protein] synthase activity
LH59_21205	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LH59_21210	COG1538	Outer membrane efflux protein
LH59_21215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH59_21220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH59_21245	COG3842	ATPase activity
LH59_21250	COG4149	molybdate abc transporter
LH59_21255	COG0725	ABC transporter, periplasmic molybdate-binding protein
LH59_21260	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LH59_21285	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LH59_21295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_21305	COG4120	Belongs to the binding-protein-dependent transport system permease family
LH59_21315	COG0667	Aldo Keto reductase
LH59_21325	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_21330	COG1024	Enoyl-CoA hydratase
LH59_21340	COG1802	Transcriptional regulator
LH59_21350	COG0183	Belongs to the thiolase family
LH59_21355	COG1960	acyl-CoA dehydrogenase activity
LH59_21360	COG1960	acyl-CoA dehydrogenase activity
LH59_21365	COG0583	DNA-binding transcription factor activity
LH59_21390	COG4213	ABC transporter substrate-binding protein
LH59_21395	COG1129	ABC transporter
LH59_21400	COG4214	carbohydrate transport
LH59_21405	COG2706	6-phosphogluconolactonase activity
LH59_21410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_21425	COG3448	diguanylate cyclase activity
LH59_21425	COG4175	Glycine betaine
LH59_21430	COG4176	ABC-type proline glycine betaine transport system permease component
LH59_21440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LH59_21445	COG2814	Major facilitator Superfamily
LH59_21450	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LH59_21455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LH59_21490	COG1686	Belongs to the peptidase S11 family
LH59_21500	COG1846	Transcriptional regulator
LH59_21505	COG2814	Major facilitator Superfamily
LH59_21510	COG0495	leucyl-tRNA aminoacylation
LH59_21525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LH59_21545	COG0154	amidase activity
LH59_21555	COG0477	Major facilitator Superfamily
LH59_21565	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_21580	COG0583	DNA-binding transcription factor activity
LH59_21630	COG0583	DNA-binding transcription factor activity
LH59_21635	COG0427	acetyl-CoA hydrolase
LH59_21640	COG0583	DNA-binding transcription factor activity
LH59_21645	COG1511	domain protein
LH59_21645	COG3264	Mechanosensitive ion channel
LH59_21695	COG3842	ATPase activity
LH59_21700	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH59_21705	COG1177	transmembrane transport
LH59_21710	COG3938	Belongs to the proline racemase family
LH59_21725	COG0517	IMP dehydrogenase activity
LH59_21755	COG0500	methyltransferase
LH59_21770	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LH59_21790	COG0667	Aldo Keto reductase
LH59_21795	COG2207	Transcriptional regulator
LH59_21800	COG0583	DNA-binding transcription factor activity
LH59_21805	COG1335	isochorismatase
LH59_21815	COG2841	Protein conserved in bacteria
LH59_21830	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH59_21835	COG0438	transferase activity, transferring glycosyl groups
LH59_21870	COG2814	Major facilitator Superfamily
LH59_21875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH59_21915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH59_21925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LH59_21930	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LH59_21935	COG1534	Rna-binding protein
LH59_21940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LH59_21945	COG0840	transmembrane signaling receptor activity
LH59_21950	COG2233	PERMEase
LH59_21960	COG1840	ABC-type Fe3 transport system, periplasmic component
LH59_21985	COG4221	oxidoreductase activity
LH59_21995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LH59_22000	COG0505	Belongs to the CarA family
LH59_22005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LH59_22020	COG0745	RESPONSE REGULATOR receiver
LH59_22035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_22045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_22050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_22055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LH59_22080	COG1074	ATP-dependent DNA helicase activity
LH59_22100	COG2070	2-Nitropropane dioxygenase
LH59_22135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH59_22140	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_22155	COG1686	Belongs to the peptidase S11 family
LH59_22170	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LH59_22175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LH59_22180	COG4974	Belongs to the 'phage' integrase family
LH59_22185	COG0583	DNA-binding transcription factor activity
LH59_22190	COG0028	Belongs to the TPP enzyme family
LH59_22235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LH59_22275	COG0411	ABC transporter
LH59_22285	COG0028	Belongs to the TPP enzyme family
LH59_22290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_22305	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LH59_22310	COG1414	Transcriptional regulator
LH59_22315	COG0009	L-threonylcarbamoyladenylate synthase
LH59_22320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LH59_22325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LH59_22330	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LH59_22340	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LH59_22360	COG1301	dicarboxylic acid transport
LH59_22370	COG3454	Phosphonate metabolism
LH59_22375	COG4778	phosphonate C-P lyase system protein PhnL
LH59_22380	COG4107	phosphonate C-P lyase system protein PhnK
LH59_22385	COG3627	carbon phosphorus lyase activity
LH59_22390	COG3626	phosphonate metabolism
LH59_22395	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
LH59_22400	COG3624	Phosphonate C-P lyase system protein PhnG
LH59_22405	COG2188	Transcriptional regulator
LH59_22410	COG3454	Phosphonate metabolism
LH59_22415	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LH59_22420	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LH59_22425	COG0583	DNA-binding transcription factor activity
LH59_22430	COG0405	Gamma-glutamyltransferase
LH59_22445	COG3639	organic phosphonate transmembrane transporter activity
LH59_22450	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LH59_22455	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LH59_22465	COG0640	Transcriptional regulator
LH59_22475	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LH59_22485	COG0739	heme binding
LH59_22495	COG0521	Mo-molybdopterin cofactor biosynthetic process
LH59_22510	COG0306	phosphate transporter
LH59_22545	COG0625	glutathione transferase activity
LH59_22565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LH59_22570	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LH59_22585	COG0126	phosphoglycerate kinase activity
LH59_22590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LH59_22595	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LH59_22605	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LH59_22610	COG2732	(Barnase) inhibitor
LH59_22620	COG0280	phosphate acetyltransferase
LH59_22620	COG0281	malic enzyme
LH59_22630	COG0436	Aminotransferase
LH59_22645	COG0741	lytic transglycosylase activity
LH59_22650	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LH59_22665	COG4575	ribosome binding
LH59_22675	COG1116	anion transmembrane transporter activity
LH59_22680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_22685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_22690	COG1648	precorrin-2 dehydrogenase activity
LH59_22690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LH59_22695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LH59_22700	COG2027	D-alanyl-D-alanine carboxypeptidase
LH59_22715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH59_22725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LH59_22730	COG0343	queuine tRNA-ribosyltransferase activity
LH59_22735	COG1862	Preprotein translocase
LH59_22740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LH59_22745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LH59_22765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LH59_22775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH59_22780	COG1702	phosphate starvation-inducible protein PhoH
LH59_22785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LH59_22790	COG4535	Mg2 and Co2 transporter CorC
LH59_22795	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LH59_22800	COG0667	Aldo Keto reductase
LH59_22840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LH59_22845	COG0697	spore germination
LH59_22855	COG0678	peroxiredoxin activity
LH59_22865	COG0412	Dienelactone hydrolase
LH59_22875	COG0315	cyclic pyranopterin monophosphate synthase activity
LH59_22885	COG0314	molybdopterin synthase activity
LH59_22890	COG0521	Mo-molybdopterin cofactor biosynthetic process
LH59_22895	COG0303	'Molybdopterin
LH59_22905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LH59_22925	COG3383	formate dehydrogenase (NAD+) activity
LH59_22930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LH59_22965	COG0583	DNA-binding transcription factor activity
LH59_22970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LH59_22985	COG2205	protein histidine kinase activity
LH59_22990	COG0745	RESPONSE REGULATOR receiver
LH59_23005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LH59_23020	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_23040	COG2828	Protein conserved in bacteria
LH59_23045	COG0583	DNA-binding transcription factor activity
LH59_23050	COG0456	acetyltransferase
LH59_23095	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_23105	COG0411	ABC transporter
LH59_23110	COG0410	ABC transporter
LH59_23120	COG4774	siderophore transport
LH59_23140	COG4585	Histidine kinase
LH59_23150	COG0671	phosphoesterase, PA-phosphatase related
LH59_23155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LH59_23165	COG1666	GTP binding
LH59_23170	COG1120	ATPase activity
LH59_23175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_23180	COG4558	Periplasmic binding protein
LH59_23185	COG3720	iron ion transport
LH59_23195	COG3712	iron ion homeostasis
LH59_23200	COG1595	DNA-templated transcription, initiation
LH59_23220	COG2378	regulation of single-species biofilm formation
LH59_23250	COG1113	amino acid transport
LH59_23260	COG1522	sequence-specific DNA binding
LH59_23265	COG1272	protein, Hemolysin III
LH59_23270	COG3191	aminopeptidase activity
LH59_23275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_23280	COG0765	amino acid transport
LH59_23290	COG4942	peptidase
LH59_23310	COG1999	signal sequence binding
LH59_23330	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LH59_23340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH59_23345	COG1845	cytochrome c oxidase, subunit III
LH59_23350	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LH59_23360	COG4772	TonB-dependent receptor
LH59_23380	COG0280	phosphate acetyltransferase
LH59_23380	COG0281	malic enzyme
LH59_23395	COG0697	spore germination
LH59_23430	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_23440	COG0583	DNA-binding transcription factor activity
LH59_23460	COG1396	sequence-specific DNA binding
LH59_23465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH59_23505	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LH59_23510	COG1285	pathogenesis
LH59_23515	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_23520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH59_23550	COG3712	iron ion homeostasis
LH59_23555	COG1595	DNA-templated transcription, initiation
LH59_23560	COG4773	Receptor
LH59_23580	COG5001	Diguanylate cyclase
LH59_23585	COG0330	HflC and HflK could
LH59_23615	COG2807	transmembrane transport
LH59_23620	COG2207	Transcriptional regulator
LH59_23625	COG4106	trans-aconitate 2-methyltransferase activity
LH59_23640	COG0583	DNA-binding transcription factor activity
LH59_23670	COG3712	iron ion homeostasis
LH59_23695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LH59_23700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_23705	COG0477	Major facilitator Superfamily
LH59_23710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LH59_23715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH59_23720	COG1845	cytochrome c oxidase, subunit III
LH59_23725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LH59_23735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_23740	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_23750	COG2814	Major facilitator Superfamily
LH59_23765	COG0625	glutathione transferase activity
LH59_23815	COG3707	response regulator
LH59_23820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH59_23820	COG2146	nitrite reductase [NAD(P)H] activity
LH59_23825	COG2146	nitrite reductase [NAD(P)H] activity
LH59_23825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH59_23835	COG0667	Aldo Keto reductase
LH59_23855	COG0583	DNA-binding transcription factor activity
LH59_23860	COG0023	Translation Initiation Factor
LH59_23870	COG0456	acetyltransferase
LH59_23870	COG0454	-acetyltransferase
LH59_23875	COG0583	DNA-binding transcription factor activity
LH59_23880	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_23895	COG0840	transmembrane signaling receptor activity
LH59_23900	COG2203	Gaf domain
LH59_23900	COG2199	diguanylate cyclase activity
LH59_23905	COG0640	Transcriptional regulator
LH59_23915	COG0740	serine-type endopeptidase activity
LH59_23920	COG2814	Major facilitator Superfamily
LH59_23950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_23960	COG0596	Alpha beta hydrolase
LH59_23970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH59_23980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH59_23985	COG0583	DNA-binding transcription factor activity
LH59_24020	COG0028	Belongs to the TPP enzyme family
LH59_24040	COG1230	cation diffusion facilitator family transporter
LH59_24060	COG1132	(ABC) transporter
LH59_24070	COG1201	RNA secondary structure unwinding
LH59_24075	COG1793	dna ligase
LH59_24080	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LH59_24080	COG1793	dna ligase
LH59_24120	COG1960	acyl-CoA dehydrogenase activity
LH59_24130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_24135	COG0697	spore germination
LH59_24145	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_24160	COG0583	DNA-binding transcription factor activity
LH59_24165	COG0583	DNA-binding transcription factor activity
LH59_24195	COG0583	DNA-binding transcription factor activity
LH59_24205	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_24210	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_24225	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_24270	COG1595	DNA-templated transcription, initiation
LH59_24295	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LH59_24300	COG0459	protein refolding
LH59_24310	COG1846	Transcriptional regulator
LH59_24330	COG1917	Cupin 2, conserved barrel domain protein
LH59_24355	COG1137	ATPase activity
LH59_24360	COG0410	ABC transporter
LH59_24370	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LH59_24375	COG1252	NADH dehydrogenase
LH59_24380	COG0284	orotidine-5'-phosphate decarboxylase activity
LH59_24385	COG1546	Belongs to the CinA family
LH59_24400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LH59_24405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LH59_24430	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LH59_24435	COG3639	organic phosphonate transmembrane transporter activity
LH59_24440	COG3639	organic phosphonate transmembrane transporter activity
LH59_24460	COG0742	ribosomal rna small subunit methyltransferase
LH59_24465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LH59_24470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LH59_24475	COG3135	benzoate transporter
LH59_24490	COG2814	Major facilitator Superfamily
LH59_24515	COG4804	nuclease activity
LH59_24520	COG0012	GTP binding
LH59_24530	COG0193	aminoacyl-tRNA hydrolase activity
LH59_24535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LH59_24540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LH59_24550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LH59_24555	COG0840	transmembrane signaling receptor activity
LH59_24570	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LH59_24595	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LH59_24605	COG0204	Acyl-transferase
LH59_24610	COG1368	sulfuric ester hydrolase activity
LH59_24615	COG2186	Transcriptional regulator
LH59_24620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_24630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_24640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LH59_24655	COG0745	RESPONSE REGULATOR receiver
LH59_24660	COG0277	FAD linked oxidase domain protein
LH59_24675	COG0166	Belongs to the GPI family
LH59_24685	COG0438	transferase activity, transferring glycosyl groups
LH59_24690	COG0438	transferase activity, transferring glycosyl groups
LH59_24695	COG0438	transferase activity, transferring glycosyl groups
LH59_24720	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LH59_24725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH59_24730	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LH59_24740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LH59_24755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_24775	COG0747	negative chemotaxis
LH59_24780	COG0601	transmembrane transport
LH59_24785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_24790	COG4172	Belongs to the ABC transporter superfamily
LH59_24795	COG0154	amidase activity
LH59_24815	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH59_24815	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH59_24820	COG0509	glycine decarboxylation via glycine cleavage system
LH59_24825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LH59_24850	COG1982	Orn Lys Arg decarboxylase major
LH59_24865	COG3706	GGDEF domain
LH59_24875	COG0717	Belongs to the dCTP deaminase family
LH59_24890	COG0489	protein tyrosine kinase activity
LH59_24900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH59_24900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH59_24920	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH59_24920	COG2755	lipolytic protein G-D-S-L family
LH59_24930	COG0745	RESPONSE REGULATOR receiver
LH59_24935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH59_24960	COG2200	EAL domain
LH59_24980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH59_24985	COG0842	Transport permease protein
LH59_24985	COG1129	ABC transporter
LH59_24990	COG0842	Transport permease protein
LH59_25000	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_25005	COG0583	DNA-binding transcription factor activity
LH59_25010	COG0697	spore germination
LH59_25015	COG1271	oxidase subunit
LH59_25020	COG1294	oxidase, subunit
LH59_25030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_25065	COG3258	Cytochrome c
LH59_25075	COG0625	glutathione transferase activity
LH59_25080	COG2986	histidine ammonia-lyase
LH59_25085	COG1234	tRNA 3'-trailer cleavage
LH59_25090	COG0477	Major facilitator Superfamily
LH59_25095	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LH59_25110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LH59_25140	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LH59_25155	COG2828	Protein conserved in bacteria
LH59_25160	COG1595	DNA-templated transcription, initiation
LH59_25165	COG3712	iron ion homeostasis
LH59_25175	COG0165	Argininosuccinate lyase
LH59_25180	COG2205	protein histidine kinase activity
LH59_25190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH59_25215	COG0625	glutathione transferase activity
LH59_25220	COG0477	Major facilitator Superfamily
LH59_25230	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_25235	COG3246	L-lysine catabolic process to acetate
LH59_25250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LH59_25255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LH59_25260	COG0154	amidase activity
LH59_25265	COG0372	Belongs to the citrate synthase family
LH59_25270	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_25315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH59_25320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_25325	COG0583	DNA-binding transcription factor activity
LH59_25330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LH59_25355	COG1652	LysM domain
LH59_25360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LH59_25365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LH59_25380	COG0625	glutathione transferase activity
LH59_25405	COG1012	belongs to the aldehyde dehydrogenase family
LH59_25445	COG3550	peptidyl-serine autophosphorylation
LH59_25465	COG1414	Transcriptional regulator
LH59_25475	COG0800	Aldolase
LH59_25480	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_25485	COG2271	Major facilitator Superfamily
LH59_25490	COG1131	(ABC) transporter
LH59_25505	COG4774	siderophore transport
LH59_25510	COG2814	Major facilitator Superfamily
LH59_25515	COG0326	Molecular chaperone. Has ATPase activity
LH59_25525	COG2233	PERMEase
LH59_25545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_25550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH59_25555	COG3246	L-lysine catabolic process to acetate
LH59_25565	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_25690	COG0583	DNA-binding transcription factor activity
LH59_25700	COG1695	Transcriptional regulator
LH59_25715	COG0477	Major facilitator Superfamily
LH59_25730	COG0277	FAD linked oxidase domain protein
LH59_25740	COG3842	ATPase activity
LH59_25745	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH59_25765	COG0628	permease
LH59_25770	COG0583	DNA-binding transcription factor activity
LH59_25775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH59_25795	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
LH59_25805	COG2186	Transcriptional regulator
LH59_25815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LH59_25825	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_25835	COG0411	ABC transporter
LH59_25840	COG0410	ABC transporter
LH59_25845	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_25850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LH59_25860	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH59_25865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH59_25870	COG0583	DNA-binding transcription factor activity
LH59_25875	COG0129	dihydroxy-acid dehydratase activity
LH59_25885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH59_25890	COG0583	DNA-binding transcription factor activity
LH59_25905	COG2200	EAL domain
LH59_25910	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LH59_25915	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LH59_25920	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_25925	COG2031	fatty acid transporter
LH59_25930	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_25935	COG1414	Transcriptional regulator
LH59_25945	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LH59_25960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH59_25980	COG0288	reversible hydration of carbon dioxide
LH59_25985	COG1802	Transcriptional regulator
LH59_25990	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_26000	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_26015	COG0410	ABC transporter
LH59_26020	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_26035	COG0625	glutathione transferase activity
LH59_26050	COG0583	DNA-binding transcription factor activity
LH59_26060	COG0583	DNA-binding transcription factor activity
LH59_26065	COG0477	Major facilitator Superfamily
LH59_26090	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_26110	COG1464	Belongs to the NlpA lipoprotein family
LH59_26125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LH59_26130	COG2890	protein-(glutamine-N5) methyltransferase activity
LH59_26135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LH59_26140	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LH59_26150	COG1280	lysine exporter protein (LysE YggA)
LH59_26155	COG1522	sequence-specific DNA binding
LH59_26175	COG3622	Belongs to the hyi family
LH59_26190	COG0477	Major facilitator Superfamily
LH59_26200	COG2186	Transcriptional regulator
LH59_26205	COG3395	kinase activity
LH59_26210	COG2084	Dehydrogenase
LH59_26215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_26220	COG3622	Belongs to the hyi family
LH59_26225	COG0235	Class ii aldolase
LH59_26275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH59_26295	COG0142	geranyltranstransferase activity
LH59_26300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LH59_26305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LH59_26310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LH59_26315	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LH59_26330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LH59_26335	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LH59_26345	COG2186	Transcriptional regulator
LH59_26350	COG5001	Diguanylate cyclase
LH59_26350	COG3447	MASE1 domain protein
LH59_26350	COG5002	protein histidine kinase activity
LH59_26355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LH59_26360	COG0793	Belongs to the peptidase S41A family
LH59_26365	COG4942	peptidase
LH59_26370	COG0588	phosphoglycerate mutase activity
LH59_26380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LH59_26385	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LH59_26390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LH59_26395	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_26405	COG1040	competence protein
LH59_26410	COG2226	methyltransferase
LH59_26415	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LH59_26420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LH59_26425	COG0569	domain protein
LH59_26430	COG2204	response regulator
LH59_26435	COG5000	phosphorelay sensor kinase activity
LH59_26445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LH59_26445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LH59_26450	COG1280	lysine exporter protein (LysE YggA)
LH59_26460	COG2076	Multidrug Resistance protein
LH59_26465	COG1733	regulation of RNA biosynthetic process
LH59_26485	COG0546	phosphoglycolate phosphatase activity
LH59_26495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LH59_26500	COG0242	peptide deformylase activity
LH59_26505	COG0758	DNA mediated transformation
LH59_26520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_26525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_26530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LH59_26535	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_26550	COG1238	metal cluster binding
LH59_26555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LH59_26560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_26575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LH59_26580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LH59_26585	COG4988	ABC transporter
LH59_26595	COG1294	oxidase, subunit
LH59_26610	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LH59_26620	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LH59_26635	COG1137	ATPase activity
LH59_26640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LH59_26650	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LH59_26655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_26670	COG1660	Displays ATPase and GTPase activities
LH59_26680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LH59_26690	COG0792	nuclease activity
LH59_26695	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LH59_26705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH59_26715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LH59_26725	COG1309	transcriptional regulator
LH59_26730	COG0471	metal ion transport
LH59_26735	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LH59_26740	COG0772	Belongs to the SEDS family
LH59_26745	COG0768	penicillin binding
LH59_26755	COG1792	Involved in formation and maintenance of cell shape
LH59_26760	COG1077	Cell shape determining protein MreB Mrl
LH59_26765	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LH59_26770	COG0154	amidase activity
LH59_26775	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LH59_26785	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LH59_26790	COG0708	Exodeoxyribonuclease III
LH59_26795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LH59_26805	COG0583	DNA-binding transcription factor activity
LH59_26815	COG0583	DNA-binding transcription factor activity
LH59_26830	COG0411	ABC transporter
LH59_26840	COG1764	response to oxidative stress
LH59_26845	COG1846	Transcriptional regulator
LH59_26910	COG0640	Transcriptional regulator
LH59_26935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LH59_26940	COG3189	MarR family transcriptional regulator
LH59_26960	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_26965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LH59_26965	COG0351	phosphomethylpyrimidine kinase
LH59_26965	COG0352	thiamine-phosphate diphosphorylase activity
LH59_26975	COG0443	Heat shock 70 kDa protein
LH59_26985	COG3210	domain, Protein
LH59_26995	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LH59_27000	COG0513	Belongs to the DEAD box helicase family
LH59_27010	COG0617	tRNA 3'-terminal CCA addition
LH59_27020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LH59_27025	COG2308	Evidence 4 Homologs of previously reported genes of
LH59_27035	COG1305	Transglutaminase-like
LH59_27055	COG1950	PFAM Membrane protein of
LH59_27060	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LH59_27065	COG0438	transferase activity, transferring glycosyl groups
LH59_27080	COG0066	3-isopropylmalate dehydratase activity
LH59_27090	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_27095	COG0583	DNA-binding transcription factor activity
LH59_27105	COG0477	Major facilitator Superfamily
LH59_27110	COG0154	amidase activity
LH59_27115	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LH59_27130	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LH59_27140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LH59_27145	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LH59_27155	COG0803	Belongs to the bacterial solute-binding protein 9 family
LH59_27175	COG0735	belongs to the Fur family
LH59_27180	COG0523	cobalamin synthesis protein
LH59_27185	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LH59_27190	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LH59_27195	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LH59_27205	COG2096	Adenosyltransferase
LH59_27210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LH59_27225	COG0321	lipoyl(octanoyl) transferase activity
LH59_27230	COG2921	Belongs to the UPF0250 family
LH59_27240	COG1686	Belongs to the peptidase S11 family
LH59_27265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LH59_27275	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LH59_27290	COG0859	PFAM glycosyl transferase family 9
LH59_27315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LH59_27350	COG0367	asparagine synthase
LH59_27365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_27375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LH59_27385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LH59_27400	COG0175	sulfate reduction
LH59_27430	COG2226	methyltransferase
LH59_27445	COG0367	asparagine synthase
LH59_27460	COG2814	Major facilitator Superfamily
LH59_27465	COG0697	spore germination
LH59_27490	COG3568	Endonuclease Exonuclease Phosphatase
LH59_27495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LH59_27520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LH59_27535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_27540	COG1956	GAF domain-containing protein
LH59_27545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_27570	COG2186	Transcriptional regulator
LH59_27575	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LH59_27620	COG4106	trans-aconitate 2-methyltransferase activity
LH59_27625	COG0629	single-stranded DNA binding
LH59_27630	COG2814	Major facilitator Superfamily
LH59_27640	COG0625	glutathione transferase activity
LH59_27645	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LH59_27650	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LH59_27655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LH59_27665	COG1965	Belongs to the frataxin family
LH59_27670	COG0019	diaminopimelate decarboxylase activity
LH59_27680	COG1333	cytochrome c biogenesis protein
LH59_27690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LH59_27705	COG4232	protein-disulfide reductase activity
LH59_27710	COG1324	tolerance protein
LH59_27720	COG0203	ribosomal protein L17
LH59_27725	COG0202	RNA polymerase activity
LH59_27730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LH59_27735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LH59_27740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LH59_27745	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LH59_27750	COG0201	protein transport
LH59_27755	COG0200	Binds to the 23S rRNA
LH59_27760	COG1841	ribosomal large subunit assembly
LH59_27765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LH59_27770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LH59_27775	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LH59_27780	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LH59_27785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LH59_27790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LH59_27795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LH59_27800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LH59_27815	COG2169	Transcriptional regulator
LH59_27815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LH59_27830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH59_27845	COG0410	ABC transporter
LH59_27850	COG4177	L-phenylalanine transmembrane transporter activity
LH59_27865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LH59_27870	COG0255	Belongs to the universal ribosomal protein uL29 family
LH59_27875	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LH59_27880	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LH59_27885	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LH59_27890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LH59_27895	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LH59_27900	COG0089	rRNA binding
LH59_27905	COG0088	Forms part of the polypeptide exit tunnel
LH59_27910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LH59_27915	COG0051	transcription antitermination factor activity, RNA binding
LH59_27925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LH59_27930	COG0049	tRNA binding
LH59_27935	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LH59_27940	COG0745	RESPONSE REGULATOR receiver
LH59_27955	COG5002	protein histidine kinase activity
LH59_27970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LH59_27975	COG0085	RNA polymerase activity
LH59_27980	COG0222	ribosome binding
LH59_27985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LH59_27990	COG0081	regulation of translation
LH59_27995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LH59_28005	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH59_28015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LH59_28055	COG1840	ABC-type Fe3 transport system, periplasmic component
LH59_28060	COG3842	ATPase activity
LH59_28070	COG1349	DNA-binding transcription factor activity
LH59_28095	COG0583	DNA-binding transcription factor activity
LH59_28100	COG0252	asparaginase activity
LH59_28105	COG1475	DNA binding
LH59_28115	COG1192	Involved in chromosome partitioning
LH59_28120	COG0357	Ribosomal RNA small subunit methyltransferase G
LH59_28125	COG0445	tRNA wobble uridine modification
LH59_28130	COG1278	Cold shock
LH59_28135	COG3180	Ammonia monooxygenase
LH59_28140	COG0436	Aminotransferase
LH59_28170	COG0038	chloride channel
LH59_28185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LH59_28195	COG0601	transmembrane transport
LH59_28200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_28205	COG0444	Belongs to the ABC transporter superfamily
LH59_28210	COG4608	Belongs to the ABC transporter superfamily
LH59_28215	COG1473	amidohydrolase
LH59_28230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LH59_28235	COG0753	catalase activity
LH59_28250	COG0594	ribonuclease P activity
LH59_28255	COG0230	Belongs to the bacterial ribosomal protein bL34 family