locus-tag	class	description
I6I48_00015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I48_00020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I48_00045	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I48_00050	COG3639	organic phosphonate transmembrane transporter activity
I6I48_00055	COG3639	organic phosphonate transmembrane transporter activity
I6I48_00075	COG0742	ribosomal rna small subunit methyltransferase
I6I48_00080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I48_00085	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I48_00090	COG3135	benzoate transporter
I6I48_00105	COG2814	Major facilitator Superfamily
I6I48_00120	COG0488	(ABC) transporter
I6I48_00125	COG4773	Receptor
I6I48_00130	COG4804	nuclease activity
I6I48_00135	COG0012	GTP binding
I6I48_00145	COG0193	aminoacyl-tRNA hydrolase activity
I6I48_00165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I48_00185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I48_00210	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6I48_00220	COG0204	Acyl-transferase
I6I48_00225	COG1368	sulfuric ester hydrolase activity
I6I48_00230	COG2186	Transcriptional regulator
I6I48_00235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I48_00245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_00255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_00255	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I48_00270	COG0745	RESPONSE REGULATOR receiver
I6I48_00275	COG0277	FAD linked oxidase domain protein
I6I48_00290	COG0166	Belongs to the GPI family
I6I48_00295	COG0405	Gamma-glutamyltransferase
I6I48_00300	COG0438	transferase activity, transferring glycosyl groups
I6I48_00305	COG0438	transferase activity, transferring glycosyl groups
I6I48_00310	COG0438	transferase activity, transferring glycosyl groups
I6I48_00335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I48_00340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I48_00370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_00375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I48_00390	COG0747	negative chemotaxis
I6I48_00395	COG0601	transmembrane transport
I6I48_00400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_00405	COG4172	Belongs to the ABC transporter superfamily
I6I48_00410	COG0154	amidase activity
I6I48_00425	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I48_00425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I48_00430	COG0509	glycine decarboxylation via glycine cleavage system
I6I48_00435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I48_00450	COG2081	HI0933 family
I6I48_00470	COG3706	GGDEF domain
I6I48_00480	COG0717	Belongs to the dCTP deaminase family
I6I48_00495	COG0489	protein tyrosine kinase activity
I6I48_00505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I48_00505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I48_00510	COG1054	Belongs to the UPF0176 family
I6I48_00525	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I48_00525	COG2755	lipolytic protein G-D-S-L family
I6I48_00540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I48_00565	COG2200	EAL domain
I6I48_00585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_00590	COG0842	Transport permease protein
I6I48_00590	COG1129	ABC transporter
I6I48_00595	COG0842	Transport permease protein
I6I48_00605	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_00610	COG0583	DNA-binding transcription factor activity
I6I48_00615	COG0697	spore germination
I6I48_00625	COG1271	oxidase subunit
I6I48_00630	COG1294	oxidase, subunit
I6I48_00640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_00675	COG3258	Cytochrome c
I6I48_00685	COG0625	glutathione transferase activity
I6I48_00690	COG2986	histidine ammonia-lyase
I6I48_00695	COG1234	tRNA 3'-trailer cleavage
I6I48_00705	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I48_00720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I48_00750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I48_00765	COG2828	Protein conserved in bacteria
I6I48_00770	COG1595	DNA-templated transcription, initiation
I6I48_00775	COG3712	iron ion homeostasis
I6I48_00785	COG0165	Argininosuccinate lyase
I6I48_00790	COG2205	protein histidine kinase activity
I6I48_00800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I48_00830	COG0477	Major facilitator Superfamily
I6I48_00840	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_00845	COG3246	L-lysine catabolic process to acetate
I6I48_00860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I48_00865	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I48_00870	COG0154	amidase activity
I6I48_00875	COG0372	Belongs to the citrate synthase family
I6I48_00880	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_00905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I48_00910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_00915	COG0583	DNA-binding transcription factor activity
I6I48_00920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I48_00940	COG1652	LysM domain
I6I48_00945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I48_00950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I48_00965	COG0625	glutathione transferase activity
I6I48_00985	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_01030	COG1414	Transcriptional regulator
I6I48_01035	COG3734	2-keto-3-deoxy-galactonokinase
I6I48_01040	COG0800	Aldolase
I6I48_01045	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_01050	COG2271	Major facilitator Superfamily
I6I48_01055	COG1131	(ABC) transporter
I6I48_01070	COG4774	siderophore transport
I6I48_01075	COG2814	Major facilitator Superfamily
I6I48_01080	COG3550	peptidyl-serine autophosphorylation
I6I48_01085	COG1396	sequence-specific DNA binding
I6I48_01090	COG0326	Molecular chaperone. Has ATPase activity
I6I48_01100	COG2233	PERMEase
I6I48_01135	COG3451	type IV secretory pathway VirB4
I6I48_01145	COG3838	Conjugal transfer protein Trbc
I6I48_01150	COG4962	Type ii secretion system protein e
I6I48_01170	COG0583	DNA-binding transcription factor activity
I6I48_01185	COG1960	acyl-CoA dehydrogenase activity
I6I48_01200	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_01210	COG1960	acyl-CoA dehydrogenase activity
I6I48_01215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_01220	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_01225	COG0183	Belongs to the thiolase family
I6I48_01230	COG1024	Enoyl-CoA hydratase
I6I48_01240	COG0625	glutathione transferase activity
I6I48_01285	COG4959	Type IV secretory pathway protease TraF
I6I48_01300	COG1192	Involved in chromosome partitioning
I6I48_01330	COG5489	Protein of unknown function (DUF736)
I6I48_01355	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_01380	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_01390	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_01395	COG0183	Belongs to the thiolase family
I6I48_01400	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_01440	COG4804	nuclease activity
I6I48_01480	COG2433	Pfam Transposase IS66
I6I48_01500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_01505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I48_01510	COG3246	L-lysine catabolic process to acetate
I6I48_01520	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_01630	COG2198	Histidine kinase
I6I48_01630	COG0784	Response regulator, receiver
I6I48_01630	COG5002	protein histidine kinase activity
I6I48_01660	COG0583	DNA-binding transcription factor activity
I6I48_01670	COG1695	Transcriptional regulator
I6I48_01685	COG0477	Major facilitator Superfamily
I6I48_01700	COG0277	FAD linked oxidase domain protein
I6I48_01710	COG3842	ATPase activity
I6I48_01715	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I48_01735	COG0628	permease
I6I48_01740	COG0583	DNA-binding transcription factor activity
I6I48_01745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_01765	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I6I48_01775	COG2186	Transcriptional regulator
I6I48_01785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I48_01810	COG0410	ABC transporter
I6I48_01815	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_01820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I48_01830	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I48_01835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I48_01840	COG0583	DNA-binding transcription factor activity
I6I48_01845	COG0129	dihydroxy-acid dehydratase activity
I6I48_01855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I48_01860	COG0583	DNA-binding transcription factor activity
I6I48_01875	COG2200	EAL domain
I6I48_01880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I48_01885	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I48_01890	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_01895	COG2031	fatty acid transporter
I6I48_01900	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_01905	COG1414	Transcriptional regulator
I6I48_01915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I48_01920	COG4829	muconolactone delta-isomerase
I6I48_01930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I48_01950	COG0288	reversible hydration of carbon dioxide
I6I48_01955	COG1802	Transcriptional regulator
I6I48_01960	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_01970	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_01990	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_02000	COG1053	succinate dehydrogenase
I6I48_02005	COG0625	glutathione transferase activity
I6I48_02030	COG0583	DNA-binding transcription factor activity
I6I48_02035	COG0477	Major facilitator Superfamily
I6I48_02060	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_02080	COG1464	Belongs to the NlpA lipoprotein family
I6I48_02095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I48_02100	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I48_02105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I48_02120	COG1280	lysine exporter protein (LysE YggA)
I6I48_02125	COG1522	sequence-specific DNA binding
I6I48_02145	COG3622	Belongs to the hyi family
I6I48_02165	COG0583	DNA-binding transcription factor activity
I6I48_02170	COG2186	Transcriptional regulator
I6I48_02175	COG3395	kinase activity
I6I48_02180	COG2084	Dehydrogenase
I6I48_02185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I48_02190	COG3622	Belongs to the hyi family
I6I48_02195	COG0235	Class ii aldolase
I6I48_02265	COG0142	geranyltranstransferase activity
I6I48_02270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I48_02275	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I48_02280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I48_02285	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I48_02300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I48_02305	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I48_02315	COG2186	Transcriptional regulator
I6I48_02320	COG3447	MASE1 domain protein
I6I48_02320	COG5001	Diguanylate cyclase
I6I48_02320	COG5002	protein histidine kinase activity
I6I48_02325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I48_02330	COG0793	Belongs to the peptidase S41A family
I6I48_02335	COG4942	peptidase
I6I48_02340	COG0588	phosphoglycerate mutase activity
I6I48_02350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I48_02355	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6I48_02360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I48_02365	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_02375	COG1040	competence protein
I6I48_02380	COG2226	methyltransferase
I6I48_02385	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6I48_02390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I48_02395	COG0569	domain protein
I6I48_02400	COG2204	response regulator
I6I48_02405	COG5000	phosphorelay sensor kinase activity
I6I48_02415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I48_02415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I48_02420	COG1280	lysine exporter protein (LysE YggA)
I6I48_02425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I48_02435	COG1733	regulation of RNA biosynthetic process
I6I48_02455	COG0546	phosphoglycolate phosphatase activity
I6I48_02465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I48_02470	COG0242	peptide deformylase activity
I6I48_02475	COG0758	DNA mediated transformation
I6I48_02490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_02495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_02500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I48_02505	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_02520	COG1238	metal cluster binding
I6I48_02525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I48_02530	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_02545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I48_02550	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I48_02555	COG4988	ABC transporter
I6I48_02565	COG1294	oxidase, subunit
I6I48_02580	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I48_02590	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I48_02605	COG1137	ATPase activity
I6I48_02610	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I48_02620	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6I48_02625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_02640	COG1660	Displays ATPase and GTPase activities
I6I48_02650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I48_02660	COG0792	nuclease activity
I6I48_02665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6I48_02675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_02680	COG1464	Belongs to the NlpA lipoprotein family
I6I48_02685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I48_02695	COG1309	transcriptional regulator
I6I48_02700	COG0471	metal ion transport
I6I48_02705	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I48_02710	COG0772	Belongs to the SEDS family
I6I48_02715	COG0768	penicillin binding
I6I48_02725	COG1792	Involved in formation and maintenance of cell shape
I6I48_02730	COG1077	Cell shape determining protein MreB Mrl
I6I48_02735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I48_02740	COG0154	amidase activity
I6I48_02745	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I48_02760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I48_02765	COG0708	Exodeoxyribonuclease III
I6I48_02770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I48_02780	COG0583	DNA-binding transcription factor activity
I6I48_02790	COG0583	DNA-binding transcription factor activity
I6I48_02815	COG1764	response to oxidative stress
I6I48_02820	COG1846	Transcriptional regulator
I6I48_02880	COG0640	Transcriptional regulator
I6I48_02910	COG3189	MarR family transcriptional regulator
I6I48_02930	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_02935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I48_02935	COG0352	thiamine-phosphate diphosphorylase activity
I6I48_02935	COG0351	phosphomethylpyrimidine kinase
I6I48_02975	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I48_02980	COG0513	Belongs to the DEAD box helicase family
I6I48_02990	COG0617	tRNA 3'-terminal CCA addition
I6I48_03005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I48_03010	COG2308	Evidence 4 Homologs of previously reported genes of
I6I48_03020	COG1305	Transglutaminase-like
I6I48_03040	COG1950	PFAM Membrane protein of
I6I48_03045	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I48_03050	COG0438	transferase activity, transferring glycosyl groups
I6I48_03065	COG0066	3-isopropylmalate dehydratase activity
I6I48_03080	COG0583	DNA-binding transcription factor activity
I6I48_03085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I48_03120	COG0477	Major facilitator Superfamily
I6I48_03125	COG0154	amidase activity
I6I48_03130	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I48_03145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I48_03155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I48_03160	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I48_03170	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I48_03185	COG0735	belongs to the Fur family
I6I48_03190	COG0523	cobalamin synthesis protein
I6I48_03200	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I48_03205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6I48_03215	COG2096	Adenosyltransferase
I6I48_03240	COG1216	Glycosyl transferase, family 2
I6I48_03245	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I48_03325	COG0438	transferase activity, transferring glycosyl groups
I6I48_03335	COG1682	transport, permease protein
I6I48_03340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I48_03355	COG0321	lipoyl(octanoyl) transferase activity
I6I48_03360	COG2921	Belongs to the UPF0250 family
I6I48_03370	COG1686	Belongs to the peptidase S11 family
I6I48_03395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I48_03405	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6I48_03420	COG0859	PFAM glycosyl transferase family 9
I6I48_03425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I48_03435	COG2814	Major facilitator Superfamily
I6I48_03450	COG3568	Endonuclease Exonuclease Phosphatase
I6I48_03455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I48_03480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I48_03495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_03500	COG1956	GAF domain-containing protein
I6I48_03505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_03530	COG2186	Transcriptional regulator
I6I48_03565	COG4106	trans-aconitate 2-methyltransferase activity
I6I48_03575	COG2814	Major facilitator Superfamily
I6I48_03585	COG0625	glutathione transferase activity
I6I48_03590	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I48_03595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I48_03600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I48_03610	COG1965	Belongs to the frataxin family
I6I48_03620	COG0019	diaminopimelate decarboxylase activity
I6I48_03625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I48_03630	COG1333	cytochrome c biogenesis protein
I6I48_03640	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I48_03655	COG4232	protein-disulfide reductase activity
I6I48_03660	COG1324	tolerance protein
I6I48_03670	COG0203	ribosomal protein L17
I6I48_03675	COG0202	RNA polymerase activity
I6I48_03680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I48_03685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I48_03690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I48_03695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I48_03700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I48_03705	COG0201	protein transport
I6I48_03710	COG0200	Binds to the 23S rRNA
I6I48_03715	COG1841	ribosomal large subunit assembly
I6I48_03720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I48_03725	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I48_03730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I48_03735	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I48_03740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I48_03745	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I48_03750	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I48_03755	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I48_03770	COG2169	Transcriptional regulator
I6I48_03770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I48_03785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I48_03820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I48_03825	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I48_03830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I48_03835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I48_03840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I48_03845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I48_03850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I48_03855	COG0089	rRNA binding
I6I48_03865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I48_03870	COG0051	transcription antitermination factor activity, RNA binding
I6I48_03875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I48_03880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I48_03885	COG0049	tRNA binding
I6I48_03890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I48_03895	COG0745	RESPONSE REGULATOR receiver
I6I48_03910	COG5002	protein histidine kinase activity
I6I48_03925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I48_03930	COG0085	RNA polymerase activity
I6I48_03935	COG0222	ribosome binding
I6I48_03940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I48_03945	COG0081	regulation of translation
I6I48_03950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I48_03960	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I48_03970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I48_04010	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I48_04015	COG3842	ATPase activity
I6I48_04025	COG1349	DNA-binding transcription factor activity
I6I48_04050	COG0583	DNA-binding transcription factor activity
I6I48_04055	COG0252	asparaginase activity
I6I48_04060	COG1475	DNA binding
I6I48_04070	COG1192	Involved in chromosome partitioning
I6I48_04075	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I48_04080	COG0445	tRNA wobble uridine modification
I6I48_04085	COG1278	Cold shock
I6I48_04090	COG3180	Ammonia monooxygenase
I6I48_04095	COG0436	Aminotransferase
I6I48_04125	COG0038	chloride channel
I6I48_04135	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I48_04145	COG0601	transmembrane transport
I6I48_04150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_04155	COG0444	Belongs to the ABC transporter superfamily
I6I48_04160	COG4608	Belongs to the ABC transporter superfamily
I6I48_04165	COG1473	amidohydrolase
I6I48_04170	COG2175	clavaminate synthase activity
I6I48_04180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I48_04185	COG0753	catalase activity
I6I48_04195	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I48_04200	COG0594	ribonuclease P activity
I6I48_04205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I48_04210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I48_04215	COG0592	DNA-directed DNA polymerase activity
I6I48_04225	COG0583	DNA-binding transcription factor activity
I6I48_04250	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6I48_04260	COG0583	DNA-binding transcription factor activity
I6I48_04265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_04270	COG0765	amino acid transport
I6I48_04275	COG0765	amino acid transport
I6I48_04280	COG1126	abc transporter atp-binding protein
I6I48_04315	COG3842	ATPase activity
I6I48_04320	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I48_04325	COG1177	transmembrane transport
I6I48_04380	COG1609	Transcriptional regulator
I6I48_04390	COG3842	ATPase activity
I6I48_04395	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I48_04400	COG1177	transmembrane transport
I6I48_04425	COG0251	oxidation-reduction process
I6I48_04430	COG0402	S-adenosylhomocysteine deaminase activity
I6I48_04440	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6I48_04445	COG3845	ABC transporter
I6I48_04450	COG1744	ABC transporter substrate-binding protein PnrA-like
I6I48_04460	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I48_04475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I48_04490	COG2814	Major facilitator Superfamily
I6I48_04505	COG3781	membrane
I6I48_04510	COG1522	sequence-specific DNA binding
I6I48_04515	COG0028	Belongs to the TPP enzyme family
I6I48_04520	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_04525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_04550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I48_04555	COG2922	Belongs to the Smg family
I6I48_04565	COG2358	TRAP transporter, solute receptor (TAXI family
I6I48_04585	COG0765	amino acid transport
I6I48_04590	COG0765	amino acid transport
I6I48_04595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_04600	COG3422	double-strand break repair
I6I48_04605	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_04610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I48_04625	COG1204	response to ionizing radiation
I6I48_04640	COG4977	sequence-specific DNA binding
I6I48_04645	COG2814	Major facilitator Superfamily
I6I48_04655	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6I48_04665	COG3339	Conserved Protein
I6I48_04695	COG2186	Transcriptional regulator
I6I48_04700	COG2814	Major facilitator Superfamily
I6I48_04715	COG1595	DNA-templated transcription, initiation
I6I48_04720	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_04735	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_04745	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_04785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I48_04790	COG0183	Belongs to the thiolase family
I6I48_04795	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6I48_04800	COG1960	acyl-CoA dehydrogenase activity
I6I48_04805	COG1473	amidohydrolase
I6I48_04815	COG1742	UPF0060 membrane protein
I6I48_04830	COG1280	lysine exporter protein (LysE YggA)
I6I48_04855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I48_04865	COG0018	arginyl-trna synthetase
I6I48_04880	COG0395	ABC-type sugar transport system, permease component
I6I48_04885	COG1175	transmembrane transport
I6I48_04890	COG1653	transport
I6I48_04895	COG3842	ATPase activity
I6I48_04900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I48_04905	COG1609	Transcriptional regulator
I6I48_04915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I48_04930	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I48_04950	COG0583	DNA-binding transcription factor activity
I6I48_04970	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I48_04975	COG1280	lysine exporter protein (LysE YggA)
I6I48_04980	COG0513	Belongs to the DEAD box helicase family
I6I48_04985	COG5339	Protein conserved in bacteria
I6I48_04990	COG5339	Protein conserved in bacteria
I6I48_04995	COG1228	amidohydrolase
I6I48_05005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_05010	COG0601	transmembrane transport
I6I48_05015	COG0747	negative chemotaxis
I6I48_05020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I48_05030	COG3708	Transcriptional regulator
I6I48_05030	COG2207	Transcriptional regulator
I6I48_05050	COG0583	DNA-binding transcription factor activity
I6I48_05085	COG2969	positive regulation of protein catabolic process
I6I48_05090	COG0625	glutathione transferase activity
I6I48_05095	COG2857	Cytochrome c1
I6I48_05100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6I48_05105	COG0723	plastoquinol--plastocyanin reductase activity
I6I48_05110	COG1970	mechanosensitive ion channel activity
I6I48_05115	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I48_05120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I48_05135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I48_05140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I48_05145	COG0537	adenosine 5'-monophosphoramidase activity
I6I48_05150	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I48_05160	COG0107	imidazoleglycerol-phosphate synthase activity
I6I48_05165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I48_05170	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I48_05175	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I48_05180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I48_05185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I48_05190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I48_05195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I48_05205	COG0842	Transport permease protein
I6I48_05210	COG1131	(ABC) transporter
I6I48_05220	COG2853	Lipoprotein
I6I48_05225	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I48_05230	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I48_05235	COG1127	ABC transporter
I6I48_05240	COG2070	2-Nitropropane dioxygenase
I6I48_05250	COG0477	Major facilitator Superfamily
I6I48_05265	COG0583	DNA-binding transcription factor activity
I6I48_05270	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I48_05275	COG0511	ligase activity, forming carbon-carbon bonds
I6I48_05290	COG1984	allophanate hydrolase subunit 2
I6I48_05305	COG0069	glutamate synthase activity
I6I48_05305	COG0067	glutamate synthase
I6I48_05305	COG0070	glutamate synthase
I6I48_05330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I48_05350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I48_05380	COG1612	heme a metabolic process
I6I48_05390	COG1999	signal sequence binding
I6I48_05410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I48_05415	COG2814	Major facilitator Superfamily
I6I48_05425	COG0438	transferase activity, transferring glycosyl groups
I6I48_05445	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6I48_05455	COG2814	Major facilitator Superfamily
I6I48_05470	COG4774	siderophore transport
I6I48_05475	COG4592	Periplasmic binding protein
I6I48_05480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_05485	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_05490	COG1120	ATPase activity
I6I48_05495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I48_05510	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I48_05535	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6I48_05540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I48_05545	COG2814	Major facilitator Superfamily
I6I48_05550	COG0583	DNA-binding transcription factor activity
I6I48_05560	COG2423	ornithine cyclodeaminase activity
I6I48_05565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I48_05570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I48_05580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I48_05590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I48_05595	COG0463	Glycosyl transferase, family 2
I6I48_05645	COG0737	Belongs to the 5'-nucleotidase family
I6I48_05660	COG2188	Transcriptional regulator
I6I48_05670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I48_05675	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6I48_05690	COG0840	transmembrane signaling receptor activity
I6I48_05695	COG2814	Major facilitator Superfamily
I6I48_05710	COG3188	usher protein
I6I48_05770	COG1802	Transcriptional regulator
I6I48_05780	COG3069	C4-dicarboxylate transmembrane transporter activity
I6I48_05785	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_05810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_05820	COG0747	negative chemotaxis
I6I48_05845	COG1464	Belongs to the NlpA lipoprotein family
I6I48_05850	COG0431	NADPH-dependent FMN reductase
I6I48_05855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I48_05860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I48_05865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_05880	COG2011	ABC-type metal ion transport system permease component
I6I48_05885	COG1464	Belongs to the NlpA lipoprotein family
I6I48_05890	COG1116	anion transmembrane transporter activity
I6I48_05895	COG3585	molybdate ion transport
I6I48_05900	COG3064	Membrane
I6I48_05925	COG1607	acyl-coa hydrolase
I6I48_05940	COG0437	4 iron, 4 sulfur cluster binding
I6I48_05945	COG2864	formate dehydrogenase
I6I48_05960	COG3276	selenocysteine insertion sequence binding
I6I48_05970	COG1215	transferase activity, transferring glycosyl groups
I6I48_05975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_05980	COG1305	Transglutaminase-like
I6I48_05985	COG0709	Synthesizes selenophosphate from selenide and ATP
I6I48_06020	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_06025	COG3284	Transcriptional regulator
I6I48_06030	COG0134	indole-3-glycerol-phosphate synthase activity
I6I48_06035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I48_06040	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I48_06050	COG0546	phosphoglycolate phosphatase activity
I6I48_06055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I48_06060	COG2967	ApaG domain
I6I48_06070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I48_06075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I48_06085	COG0037	tRNA processing
I6I48_06100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I48_06115	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_06120	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_06135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I48_06160	COG3473	Maleate cis-trans isomerase
I6I48_06165	COG0583	DNA-binding transcription factor activity
I6I48_06180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I48_06190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I48_06195	COG1024	Enoyl-CoA hydratase
I6I48_06210	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I48_06225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I48_06230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I48_06235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I48_06245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I48_06255	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I48_06260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I48_06265	COG0210	DNA helicase
I6I48_06280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I48_06285	COG4221	oxidoreductase activity
I6I48_06295	COG2171	N-acyltransferase activity
I6I48_06305	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I48_06315	COG4608	Belongs to the ABC transporter superfamily
I6I48_06330	COG0601	transmembrane transport
I6I48_06340	COG2988	succinylglutamate desuccinylase activity
I6I48_06350	COG0583	DNA-binding transcription factor activity
I6I48_06355	COG0747	negative chemotaxis
I6I48_06365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I48_06370	COG1024	Enoyl-CoA hydratase
I6I48_06375	COG1024	Enoyl-CoA hydratase
I6I48_06385	COG1309	transcriptional regulator
I6I48_06400	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_06415	COG2814	Major facilitator Superfamily
I6I48_06430	COG1764	response to oxidative stress
I6I48_06435	COG0583	DNA-binding transcription factor activity
I6I48_06445	COG1595	DNA-templated transcription, initiation
I6I48_06450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I48_06455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_06470	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I48_06490	COG1129	ABC transporter
I6I48_06505	COG1802	Transcriptional regulator
I6I48_06515	COG0583	DNA-binding transcription factor activity
I6I48_06525	COG2988	succinylglutamate desuccinylase activity
I6I48_06535	COG2918	glutathione biosynthetic process
I6I48_06565	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I48_06570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I48_06580	COG2721	sulfolactate sulfo-lyase activity
I6I48_06585	COG2721	sulfolactate sulfo-lyase activity
I6I48_06590	COG2188	Transcriptional regulator
I6I48_06595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I48_06600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I48_06600	COG2813	Specifically methylates the guanine in position
I6I48_06605	COG2223	nitrite transmembrane transporter activity
I6I48_06615	COG2860	membrane
I6I48_06620	COG1802	Transcriptional regulator
I6I48_06630	COG1984	allophanate hydrolase subunit 2
I6I48_06635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I48_06645	COG0583	DNA-binding transcription factor activity
I6I48_06660	COG4774	siderophore transport
I6I48_06665	COG3712	iron ion homeostasis
I6I48_06675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I48_06690	COG2132	Multicopper oxidase
I6I48_06715	COG0745	RESPONSE REGULATOR receiver
I6I48_06720	COG2226	methyltransferase
I6I48_06735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I48_06745	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I48_06755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I48_06760	COG0351	phosphomethylpyrimidine kinase
I6I48_06765	COG2022	thiamine diphosphate biosynthetic process
I6I48_06770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I48_06775	COG4771	TonB-dependent receptor
I6I48_06785	COG2186	Transcriptional regulator
I6I48_06800	COG1063	alcohol dehydrogenase
I6I48_06810	COG0765	amino acid transport
I6I48_06815	COG1126	abc transporter atp-binding protein
I6I48_06820	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_06825	COG0246	Mannitol dehydrogenase
I6I48_06840	COG1194	a g-specific adenine glycosylase
I6I48_06860	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6I48_06865	COG2177	Part of the ABC transporter FtsEX involved in
I6I48_06870	COG2884	Cell division ATP-binding protein ftsE
I6I48_06875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_06880	COG4597	amino acid ABC transporter
I6I48_06885	COG0765	amino acid transport
I6I48_06890	COG1126	abc transporter atp-binding protein
I6I48_06915	COG1129	ABC transporter
I6I48_06920	COG4177	L-phenylalanine transmembrane transporter activity
I6I48_06935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I48_06940	COG2081	HI0933 family
I6I48_06950	COG0077	Prephenate dehydratase
I6I48_06950	COG1605	Chorismate mutase
I6I48_06985	COG0477	Major facilitator Superfamily
I6I48_06995	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I48_07000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I48_07020	COG0237	dephospho-CoA kinase activity
I6I48_07025	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6I48_07055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_07060	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I48_07075	COG3833	ABC-type maltose transport systems, permease component
I6I48_07080	COG1175	transmembrane transport
I6I48_07085	COG3842	ATPase activity
I6I48_07105	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I48_07140	COG0410	ABC transporter
I6I48_07175	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_07180	COG1024	Enoyl-CoA hydratase
I6I48_07220	COG4638	Rieske (2fe-2S)
I6I48_07225	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6I48_07230	COG1335	isochorismatase
I6I48_07235	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_07245	COG0741	lytic transglycosylase activity
I6I48_07250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I48_07255	COG0352	thiamine-phosphate diphosphorylase activity
I6I48_07270	COG1678	Uncharacterized ACR, COG1678
I6I48_07275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I48_07285	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I48_07300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I48_07305	COG0436	Aminotransferase
I6I48_07310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_07320	COG0765	amino acid transport
I6I48_07325	COG1126	abc transporter atp-binding protein
I6I48_07330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I48_07340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I48_07345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I48_07355	COG3842	ATPase activity
I6I48_07360	COG1175	transmembrane transport
I6I48_07380	COG0557	exoribonuclease II activity
I6I48_07385	COG3150	esterase
I6I48_07390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I48_07395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_07400	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I48_07405	COG0511	ligase activity, forming carbon-carbon bonds
I6I48_07410	COG0439	Biotin carboxylase
I6I48_07415	COG2264	protein methyltransferase activity
I6I48_07425	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I48_07425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I48_07450	COG1696	Membrane protein involved in D-alanine export
I6I48_07460	COG0762	integral membrane protein
I6I48_07485	COG1522	sequence-specific DNA binding
I6I48_07490	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_07500	COG0583	DNA-binding transcription factor activity
I6I48_07515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I48_07520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I48_07520	COG1042	CoA-binding domain protein
I6I48_07520	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I48_07525	COG1335	isochorismatase
I6I48_07530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_07535	COG1116	anion transmembrane transporter activity
I6I48_07550	COG3028	Belongs to the UPF0307 family
I6I48_07555	COG0312	modulator of DNA gyrase
I6I48_07560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6I48_07570	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_07575	COG4177	L-phenylalanine transmembrane transporter activity
I6I48_07590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I48_07595	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I48_07600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I48_07610	COG0316	Belongs to the HesB IscA family
I6I48_07625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I48_07635	COG1280	lysine exporter protein (LysE YggA)
I6I48_07640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I48_07645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I48_07660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I48_07660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I48_07675	COG2766	serine protein kinase
I6I48_07680	COG2718	Belongs to the UPF0229 family
I6I48_07685	COG2719	SpoVR family
I6I48_07725	COG2433	Pfam Transposase IS66
I6I48_07755	COG1196	nuclear chromosome segregation
I6I48_07805	COG0582	viral genome integration into host DNA
I6I48_07810	COG0583	DNA-binding transcription factor activity
I6I48_07815	COG1942	4-Oxalocrotonate Tautomerase
I6I48_07825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I48_07835	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_07880	COG4789	Type iii secretion
I6I48_07985	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I48_07990	COG4790	Type iii secretion
I6I48_07995	COG4794	Type iii secretion
I6I48_08000	COG4791	protein targeting
I6I48_08005	COG4792	protein secretion
I6I48_08035	COG2770	Histidine kinase
I6I48_08035	COG2208	phosphoserine phosphatase activity
I6I48_08045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I48_08050	COG2172	sigma factor antagonist activity
I6I48_08055	COG1366	Belongs to the anti-sigma-factor antagonist family
I6I48_08095	COG0741	lytic transglycosylase activity
I6I48_08095	COG1388	LysM domain
I6I48_08100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I48_08105	COG2226	methyltransferase
I6I48_08110	COG0328	RNA-DNA hybrid ribonuclease activity
I6I48_08120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I48_08125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I48_08140	COG1671	Belongs to the UPF0178 family
I6I48_08155	COG0786	glutamate:sodium symporter activity
I6I48_08165	COG0463	Glycosyl transferase, family 2
I6I48_08170	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I48_08185	COG0583	DNA-binding transcription factor activity
I6I48_08205	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_08225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_08235	COG0583	DNA-binding transcription factor activity
I6I48_08245	COG1346	cytolysis
I6I48_08255	COG0697	spore germination
I6I48_08260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_08275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I48_08285	COG1522	sequence-specific DNA binding
I6I48_08300	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I48_08305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_08320	COG0823	Involved in the tonB-independent uptake of proteins
I6I48_08330	COG0848	biopolymer transport protein
I6I48_08335	COG0811	peptide transport
I6I48_08340	COG0824	Thioesterase
I6I48_08345	COG0442	prolyl-tRNA aminoacylation
I6I48_08375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I48_08390	COG2084	Dehydrogenase
I6I48_08395	COG0405	Gamma-glutamyltransferase
I6I48_08435	COG0129	dihydroxy-acid dehydratase activity
I6I48_08440	COG4654	Cytochrome c, class I
I6I48_08445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I48_08455	COG1522	sequence-specific DNA binding
I6I48_08495	COG0583	DNA-binding transcription factor activity
I6I48_08505	COG1473	amidohydrolase
I6I48_08510	COG0418	dihydroorotase activity
I6I48_08515	COG0488	(ABC) transporter
I6I48_08525	COG2001	Belongs to the MraZ family
I6I48_08530	COG0275	rRNA processing
I6I48_08535	COG3116	cell division
I6I48_08545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I48_08550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I48_08555	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I48_08565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I48_08570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I48_08575	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I48_08580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I48_08590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I48_08595	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6I48_08605	COG0739	heme binding
I6I48_08610	COG0653	protein targeting
I6I48_08625	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_08630	COG0028	Belongs to the TPP enzyme family
I6I48_08640	COG0300	oxidoreductase activity
I6I48_08645	COG1522	sequence-specific DNA binding
I6I48_08660	COG2239	Acts as a magnesium transporter
I6I48_08670	COG2855	membrane
I6I48_08675	COG0583	DNA-binding transcription factor activity
I6I48_08680	COG1473	amidohydrolase
I6I48_08685	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_08690	COG0483	inositol monophosphate 1-phosphatase activity
I6I48_08695	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I48_08695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_08700	COG1501	Belongs to the glycosyl hydrolase 31 family
I6I48_08705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I48_08710	COG2011	ABC-type metal ion transport system permease component
I6I48_08725	COG1595	DNA-templated transcription, initiation
I6I48_08730	COG3712	iron ion homeostasis
I6I48_08750	COG0840	transmembrane signaling receptor activity
I6I48_08755	COG0583	DNA-binding transcription factor activity
I6I48_08765	COG0735	belongs to the Fur family
I6I48_08790	COG2818	Glycosylase
I6I48_08795	COG1368	sulfuric ester hydrolase activity
I6I48_08800	COG2982	Protein involved in outer membrane biogenesis
I6I48_08815	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_08830	COG2124	cytochrome p450
I6I48_08880	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6I48_08895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I48_08910	COG3178	'Phosphotransferase
I6I48_08920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I48_08925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I48_08930	COG1929	Belongs to the glycerate kinase type-1 family
I6I48_08935	COG0469	pyruvate kinase activity
I6I48_08940	COG0700	Nucleoside recognition
I6I48_08945	COG1960	acyl-CoA dehydrogenase activity
I6I48_08950	COG0242	peptide deformylase activity
I6I48_08970	COG0204	Acyl-transferase
I6I48_08975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I48_08980	COG0751	glycine-tRNA ligase activity
I6I48_08985	COG0752	glycyl-tRNA synthetase alpha subunit
I6I48_08990	COG1024	Enoyl-CoA hydratase
I6I48_09005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_09010	COG2030	dehydratase
I6I48_09015	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_09035	COG2070	2-Nitropropane dioxygenase
I6I48_09045	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_09050	COG0183	Belongs to the thiolase family
I6I48_09060	COG1960	acyl-CoA dehydrogenase activity
I6I48_09065	COG1960	acyl-CoA dehydrogenase activity
I6I48_09070	COG1024	Enoyl-CoA hydratase
I6I48_09080	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6I48_09090	COG2301	Belongs to the HpcH HpaI aldolase family
I6I48_09095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I48_09105	COG0617	tRNA 3'-terminal CCA addition
I6I48_09120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I48_09130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I48_09135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I48_09140	COG0586	Pfam SNARE associated Golgi protein
I6I48_09150	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I48_09155	COG0802	atpase or kinase
I6I48_09160	COG0114	fumarate hydratase activity
I6I48_09170	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_09180	COG0405	Gamma-glutamyltransferase
I6I48_09185	COG0531	amino acid
I6I48_09190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_09195	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_09200	COG1960	acyl-CoA dehydrogenase activity
I6I48_09205	COG0583	DNA-binding transcription factor activity
I6I48_09210	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I48_09230	COG2175	clavaminate synthase activity
I6I48_09240	COG0583	DNA-binding transcription factor activity
I6I48_09250	COG0579	oxidoreductase
I6I48_09260	COG0259	pyridoxamine-phosphate oxidase activity
I6I48_09275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_09280	COG1136	(ABC) transporter
I6I48_09280	COG0577	efflux transmembrane transporter activity
I6I48_09285	COG1538	Outer membrane efflux protein
I6I48_09290	COG0583	DNA-binding transcription factor activity
I6I48_09310	COG0577	efflux transmembrane transporter activity
I6I48_09310	COG1136	(ABC) transporter
I6I48_09345	COG0577	efflux transmembrane transporter activity
I6I48_09345	COG1136	(ABC) transporter
I6I48_09355	COG1566	PFAM secretion protein HlyD family protein
I6I48_09360	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I48_09400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I48_09410	COG0800	Aldolase
I6I48_09425	COG1216	Glycosyl transferase, family 2
I6I48_09425	COG0463	Glycosyl transferase, family 2
I6I48_09450	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_09455	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6I48_09475	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6I48_09480	COG4638	Rieske (2fe-2S)
I6I48_09505	COG0747	negative chemotaxis
I6I48_09510	COG0601	transmembrane transport
I6I48_09515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_09520	COG0444	Belongs to the ABC transporter superfamily
I6I48_09525	COG4608	Belongs to the ABC transporter superfamily
I6I48_09545	COG2746	aminoglycoside 3-N-acetyltransferase activity
I6I48_09550	COG0488	(ABC) transporter
I6I48_09575	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I48_09580	COG2894	cell division
I6I48_09585	COG0850	regulation of cytokinetic process
I6I48_09590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I48_09600	COG1294	oxidase, subunit
I6I48_09605	COG0514	ATP-dependent DNA helicase (RecQ)
I6I48_09620	COG4191	Histidine kinase
I6I48_09625	COG2255	four-way junction helicase activity
I6I48_09635	COG1090	epimerase
I6I48_09640	COG0632	four-way junction helicase activity
I6I48_09665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I48_09675	COG0006	proline dipeptidase activity
I6I48_09690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I48_09695	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_09710	COG4783	chaperone-mediated protein folding
I6I48_09750	COG2814	Major facilitator Superfamily
I6I48_09755	COG4771	TonB-dependent receptor
I6I48_09765	COG0513	Belongs to the DEAD box helicase family
I6I48_09780	COG1058	Belongs to the CinA family
I6I48_09780	COG1546	Belongs to the CinA family
I6I48_09785	COG1414	Transcriptional regulator
I6I48_09800	COG0167	dihydroorotate dehydrogenase activity
I6I48_09805	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6I48_09810	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I48_09930	COG0629	single-stranded DNA binding
I6I48_09935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I48_09950	COG0789	Transcriptional regulator
I6I48_09960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I48_09995	COG0789	Transcriptional regulator
I6I48_10145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I48_10150	COG1569	PIN domain
I6I48_10155	COG3311	Transcriptional regulator
I6I48_10210	COG2003	Belongs to the UPF0758 family
I6I48_10285	COG1695	Transcriptional regulator
I6I48_10295	COG0798	PFAM Bile acid sodium symporter
I6I48_10310	COG0640	Transcriptional regulator
I6I48_10315	COG5002	protein histidine kinase activity
I6I48_10320	COG0745	RESPONSE REGULATOR receiver
I6I48_10325	COG2132	Multicopper oxidase
I6I48_10365	COG0583	DNA-binding transcription factor activity
I6I48_10370	COG1396	sequence-specific DNA binding
I6I48_10400	COG0582	viral genome integration into host DNA
I6I48_10425	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I48_10430	COG0735	belongs to the Fur family
I6I48_10435	COG0497	DNA recombination
I6I48_10445	COG1420	regulation of RNA biosynthetic process
I6I48_10450	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I48_10460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I48_10470	COG0443	Heat shock 70 kDa protein
I6I48_10475	COG0484	heat shock protein binding
I6I48_10485	COG0612	Peptidase, M16
I6I48_10510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I48_10545	COG0840	transmembrane signaling receptor activity
I6I48_10550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_10565	COG0745	RESPONSE REGULATOR receiver
I6I48_10570	COG2205	protein histidine kinase activity
I6I48_10575	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I48_10580	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I48_10585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I48_10600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I48_10610	COG1193	negative regulation of DNA recombination
I6I48_10615	COG0492	ferredoxin-NADP+ reductase activity
I6I48_10620	COG1674	ftsk spoiiie
I6I48_10625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I48_10630	COG0251	oxidation-reduction process
I6I48_10635	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I48_10640	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I48_10640	COG0517	IMP dehydrogenase activity
I6I48_10660	COG0601	transmembrane transport
I6I48_10675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I48_10680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I48_10685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I48_10730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_10740	COG4774	siderophore transport
I6I48_10745	COG4607	ABC-type enterochelin transport system periplasmic component
I6I48_10750	COG4604	ABC transporter, ATP-binding protein
I6I48_10755	COG4605	iron ion homeostasis
I6I48_10760	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_10765	COG1132	(ABC) transporter
I6I48_10770	COG1132	(ABC) transporter
I6I48_10770	COG2375	cellular response to nickel ion
I6I48_10790	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_10795	COG3022	response to hydroperoxide
I6I48_10800	COG1289	transmembrane transporter activity
I6I48_10805	COG0028	Belongs to the TPP enzyme family
I6I48_10810	COG0440	acetolactate synthase activity
I6I48_10815	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I48_10820	COG1183	phosphatidylcholine synthase activity
I6I48_10830	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I48_10835	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I48_10845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I48_10865	COG2207	Transcriptional regulator
I6I48_10890	COG0149	triose-phosphate isomerase activity
I6I48_10895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I48_10920	COG0840	transmembrane signaling receptor activity
I6I48_10940	COG1910	domain protein
I6I48_10960	COG1595	DNA-templated transcription, initiation
I6I48_10965	COG3712	iron ion homeostasis
I6I48_10990	COG0642	Histidine kinase
I6I48_11000	COG2851	Citrate transporter
I6I48_11005	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_11025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I48_11030	COG0784	Response regulator, receiver
I6I48_11030	COG4191	Histidine kinase
I6I48_11045	COG3604	Transcriptional regulator
I6I48_11050	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6I48_11055	COG3813	Protein conserved in bacteria
I6I48_11060	COG2354	Protein conserved in bacteria
I6I48_11065	COG4772	TonB-dependent receptor
I6I48_11070	COG1522	sequence-specific DNA binding
I6I48_11090	COG4172	Belongs to the ABC transporter superfamily
I6I48_11100	COG0747	negative chemotaxis
I6I48_11120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I48_11125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_11135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I48_11140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_11145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I48_11165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I48_11175	COG1309	transcriptional regulator
I6I48_11180	COG0583	DNA-binding transcription factor activity
I6I48_11200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I48_11225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_11230	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I48_11235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I48_11240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I48_11245	COG0649	NAD binding
I6I48_11250	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6I48_11260	COG1034	ATP synthesis coupled electron transport
I6I48_11265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6I48_11270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I48_11280	COG0713	ATP synthesis coupled electron transport
I6I48_11295	COG1007	ATP synthesis coupled electron transport
I6I48_11310	COG4774	siderophore transport
I6I48_11315	COG0560	Phosphoserine phosphatase
I6I48_11320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I48_11325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I48_11330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I48_11340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I48_11345	COG0450	alkyl hydroperoxide reductase
I6I48_11360	COG1214	PFAM Peptidase M22, glycoprotease
I6I48_11365	COG1573	uracil-dna glycosylase
I6I48_11370	COG0477	Major facilitator Superfamily
I6I48_11375	COG1196	nuclear chromosome segregation
I6I48_11385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I48_11390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I48_11400	COG2917	probably involved in intracellular septation
I6I48_11405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I48_11410	COG1122	ATPase activity
I6I48_11415	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6I48_11420	COG1268	BioY protein
I6I48_11455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I48_11490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I48_11495	COG2878	Part of a membrane complex involved in electron transport
I6I48_11510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I48_11515	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I48_11520	COG0251	oxidation-reduction process
I6I48_11530	COG3228	Belongs to the MtfA family
I6I48_11535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I48_11545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I48_11555	COG0159	tryptophan synthase activity
I6I48_11560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I48_11565	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6I48_11570	COG1530	ribonuclease E activity
I6I48_11575	COG0564	pseudouridine synthase activity
I6I48_11580	COG0546	phosphoglycolate phosphatase activity
I6I48_11585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I48_11590	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6I48_11605	COG0424	maF-like protein
I6I48_11610	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I48_11615	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I48_11625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I48_11630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I48_11640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I48_11645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I48_11670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I48_11675	COG0481	GTPase activity
I6I48_11680	COG0681	Belongs to the peptidase S26 family
I6I48_11685	COG0571	ribonuclease III activity
I6I48_11690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I48_11695	COG1381	Involved in DNA repair and RecF pathway recombination
I6I48_11745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I48_11770	COG0583	DNA-binding transcription factor activity
I6I48_11780	COG0791	NLP P60 protein
I6I48_11790	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6I48_11800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I48_11805	COG0697	spore germination
I6I48_11810	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6I48_11815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I48_11835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I48_11860	COG2153	protein acetylation
I6I48_11870	COG1446	asparaginase
I6I48_11875	COG4172	Belongs to the ABC transporter superfamily
I6I48_11880	COG0747	negative chemotaxis
I6I48_11915	COG0504	CTP synthase activity
I6I48_11925	COG0148	phosphopyruvate hydratase activity
I6I48_11940	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I48_11950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I48_11995	COG3846	protein secretion by the type IV secretion system
I6I48_12010	COG3451	type IV secretory pathway VirB4
I6I48_12020	COG3838	Conjugal transfer protein Trbc
I6I48_12025	COG4962	Type ii secretion system protein e
I6I48_12045	COG0583	DNA-binding transcription factor activity
I6I48_12100	COG4959	Type IV secretory pathway protease TraF
I6I48_12115	COG1192	Involved in chromosome partitioning
I6I48_12155	COG5489	Protein of unknown function (DUF736)
I6I48_12190	COG2003	Belongs to the UPF0758 family
I6I48_12255	COG1981	membrane
I6I48_12275	COG0039	L-malate dehydrogenase activity
I6I48_12280	COG2188	Transcriptional regulator
I6I48_12285	COG2009	succinate dehydrogenase
I6I48_12290	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I48_12295	COG1053	succinate dehydrogenase
I6I48_12300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I48_12305	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6I48_12310	COG0372	Belongs to the citrate synthase family
I6I48_12325	COG0280	phosphate acetyltransferase
I6I48_12325	COG0281	malic enzyme
I6I48_12335	COG1297	OPT oligopeptide transporter protein
I6I48_12340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I48_12355	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I48_12360	COG1522	sequence-specific DNA binding
I6I48_12365	COG0567	Dehydrogenase, E1 component
I6I48_12370	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I48_12375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I48_12380	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I48_12385	COG1595	DNA-templated transcription, initiation
I6I48_12390	COG3712	iron ion homeostasis
I6I48_12395	COG4774	siderophore transport
I6I48_12430	COG2183	response to ionizing radiation
I6I48_12435	COG1199	ATP-dependent helicase activity
I6I48_12445	COG0564	pseudouridine synthase activity
I6I48_12450	COG1496	oxidoreductase activity
I6I48_12455	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6I48_12460	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_12465	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
I6I48_12490	COG2831	hemolysin activation secretion protein
I6I48_12495	COG3210	domain, Protein
I6I48_12510	COG2823	Periplasmic or secreted lipoprotein
I6I48_12520	COG3237	CsbD-like
I6I48_12525	COG0189	ligase activity
I6I48_12525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I48_12530	COG0189	ligase activity
I6I48_12530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I48_12535	COG1132	(ABC) transporter
I6I48_12550	COG2833	Protein of unknown function (DUF455)
I6I48_12555	COG2258	MOSC domain
I6I48_12560	COG2951	lytic endotransglycosylase activity
I6I48_12575	COG1960	acyl-CoA dehydrogenase activity
I6I48_12585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I48_12595	COG1696	Membrane protein involved in D-alanine export
I6I48_12615	COG1215	transferase activity, transferring glycosyl groups
I6I48_12625	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I48_12780	COG0616	signal peptide processing
I6I48_12980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I48_12995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I48_13005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I48_13015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I48_13020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I48_13040	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6I48_13045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I48_13050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I48_13080	COG2951	lytic endotransglycosylase activity
I6I48_13085	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6I48_13110	COG2985	domain, Protein
I6I48_13115	COG1960	acyl-CoA dehydrogenase activity
I6I48_13120	COG0450	alkyl hydroperoxide reductase
I6I48_13130	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I48_13135	COG4208	sulfate ABC transporter
I6I48_13145	COG0175	sulfate reduction
I6I48_13175	COG0335	large ribosomal subunit rRNA binding
I6I48_13185	COG1162	GTPase activity
I6I48_13190	COG0501	Belongs to the peptidase M48B family
I6I48_13195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I48_13200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I48_13205	COG3327	negative regulation of DNA-templated transcription, initiation
I6I48_13210	COG3396	Phenylacetate-CoA oxygenase
I6I48_13215	COG3460	Phenylacetate-CoA oxygenase
I6I48_13220	COG3396	Phenylacetate-CoA oxygenase
I6I48_13225	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I48_13230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I48_13235	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_13240	COG1024	Enoyl-CoA hydratase
I6I48_13245	COG2050	protein possibly involved in aromatic compounds catabolism
I6I48_13255	COG0534	Mate efflux family protein
I6I48_13270	COG3483	tryptophan 2,3-dioxygenase activity
I6I48_13275	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6I48_13280	COG2003	Belongs to the UPF0758 family
I6I48_13290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I48_13295	COG0625	glutathione transferase activity
I6I48_13300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I48_13325	COG0523	cobalamin synthesis protein
I6I48_13330	COG0523	cobalamin synthesis protein
I6I48_13335	COG0583	DNA-binding transcription factor activity
I6I48_13350	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I48_13355	COG1187	pseudouridine synthase activity
I6I48_13360	COG0779	Required for maturation of 30S ribosomal subunits
I6I48_13365	COG0195	Participates in both transcription termination and antitermination
I6I48_13365	COG2251	uridine kinase activity
I6I48_13370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I48_13375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I48_13380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I48_13385	COG1217	gtp-binding protein TYPA
I6I48_13405	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_13410	COG1473	amidohydrolase
I6I48_13415	COG1611	Belongs to the LOG family
I6I48_13430	COG0412	Dienelactone hydrolase
I6I48_13440	COG1760	l-serine dehydratase
I6I48_13445	COG0501	Belongs to the peptidase M48B family
I6I48_13465	COG0583	DNA-binding transcription factor activity
I6I48_13470	COG3842	ATPase activity
I6I48_13480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I48_13485	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I48_13505	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_13515	COG1722	exodeoxyribonuclease VII activity
I6I48_13520	COG0142	geranyltranstransferase activity
I6I48_13530	COG1469	GTP cyclohydrolase I activity
I6I48_13535	COG3739	integral membrane protein
I6I48_13540	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I48_13545	COG2965	DNA replication, synthesis of RNA primer
I6I48_13550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I48_13555	COG0359	binds to the 23S rRNA
I6I48_13565	COG0305	Participates in initiation and elongation during chromosome replication
I6I48_13575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I48_13610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_13660	COG0540	Belongs to the ATCase OTCase family
I6I48_13695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I48_13700	COG2137	regulation of response to DNA damage stimulus
I6I48_13725	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I48_13730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I48_13735	COG0861	Integral membrane protein TerC family
I6I48_13740	COG0861	Integral membrane protein TerC family
I6I48_13745	COG0181	hydroxymethylbilane synthase activity
I6I48_13765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I48_13775	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_13805	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_13825	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6I48_13830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I48_13840	COG0436	Aminotransferase
I6I48_13860	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6I48_13865	COG0308	aminopeptidase N
I6I48_13880	COG0312	modulator of DNA gyrase
I6I48_13885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I48_13890	COG0277	FAD linked oxidase domain protein
I6I48_13895	COG0277	FAD linked oxidase domain protein
I6I48_13900	COG0277	FAD linked oxidase domain protein
I6I48_13905	COG0247	lactate metabolic process
I6I48_13935	COG0583	DNA-binding transcription factor activity
I6I48_13940	COG0482	sulfurtransferase activity
I6I48_13945	COG0730	response to heat
I6I48_13950	COG0625	glutathione transferase activity
I6I48_13960	COG3909	cytochrome
I6I48_13990	COG0628	permease
I6I48_14000	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6I48_14115	COG0697	spore germination
I6I48_14190	COG0419	ATPase involved in DNA repair
I6I48_14195	COG2974	May be involved in recombination
I6I48_14485	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6I48_14495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I48_14500	COG0069	glutamate synthase activity
I6I48_14505	COG2391	methyltransferase activity
I6I48_14510	COG0679	Auxin Efflux Carrier
I6I48_14540	COG0557	exoribonuclease II activity
I6I48_14545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I48_14555	COG3128	pkhd-type hydroxylase
I6I48_14560	COG0776	regulation of translation
I6I48_14590	COG0642	Histidine kinase
I6I48_14595	COG3158	transport of potassium into the cell
I6I48_14600	COG0137	argininosuccinate synthase activity
I6I48_14605	COG0583	DNA-binding transcription factor activity
I6I48_14610	COG3618	amidohydrolase
I6I48_14630	COG2945	thiolester hydrolase activity
I6I48_14630	COG0596	Alpha beta hydrolase
I6I48_14635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I48_14640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I48_14650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I48_14650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_14660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_14665	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I48_14675	COG3642	lipopolysaccharide core region biosynthetic process
I6I48_14685	COG3842	ATPase activity
I6I48_14690	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I48_14695	COG1177	transmembrane transport
I6I48_14715	COG1322	Protein conserved in bacteria
I6I48_14725	COG1960	acyl-CoA dehydrogenase activity
I6I48_14735	COG0704	Plays a role in the regulation of phosphate uptake
I6I48_14745	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6I48_14750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I48_14750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I48_14755	COG1643	Atp-dependent helicase
I6I48_14760	COG0395	ABC-type sugar transport system, permease component
I6I48_14765	COG1116	anion transmembrane transporter activity
I6I48_14780	COG0438	transferase activity, transferring glycosyl groups
I6I48_14785	COG0726	polysaccharide deacetylase
I6I48_14800	COG0726	polysaccharide deacetylase
I6I48_14825	COG1132	(ABC) transporter
I6I48_14830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I48_14830	COG0475	glutathione-regulated potassium exporter activity
I6I48_14840	COG5001	Diguanylate cyclase
I6I48_14840	COG4251	negative regulation of phosphorylation
I6I48_14840	COG3706	GGDEF domain
I6I48_14840	COG2203	Gaf domain
I6I48_15085	COG4386	tail sheath protein
I6I48_15100	COG0739	heme binding
I6I48_15100	COG0741	lytic transglycosylase activity
I6I48_15100	COG1196	nuclear chromosome segregation
I6I48_15180	COG1530	ribonuclease E activity
I6I48_15210	COG2204	response regulator
I6I48_15215	COG4191	Histidine kinase
I6I48_15220	COG1301	dicarboxylic acid transport
I6I48_15230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6I48_15235	COG0799	negative regulation of ribosome biogenesis
I6I48_15240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I48_15250	COG0151	Belongs to the GarS family
I6I48_15255	COG0217	transcriptional regulatory protein
I6I48_15260	COG0433	COG0433 Predicted ATPase
I6I48_15265	COG0473	3-isopropylmalate dehydrogenase activity
I6I48_15275	COG2814	Major facilitator Superfamily
I6I48_15280	COG1566	PFAM secretion protein HlyD family protein
I6I48_15290	COG1846	Transcriptional regulator
I6I48_15320	COG3391	amine dehydrogenase activity
I6I48_15330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I48_15350	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I48_15355	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I48_15365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I48_15390	COG1309	transcriptional regulator
I6I48_15395	COG2311	Membrane
I6I48_15400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I48_15425	COG0662	Cupin 2, conserved barrel domain protein
I6I48_15430	COG5285	phytanoyl-CoA dioxygenase
I6I48_15435	COG3217	Mosc domain protein beta barrel domain protein
I6I48_15435	COG0633	Ferredoxin
I6I48_15440	COG2076	Multidrug Resistance protein
I6I48_15455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_15470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I48_15475	COG0425	Belongs to the sulfur carrier protein TusA family
I6I48_15485	COG0228	four-way junction DNA binding
I6I48_15495	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I48_15500	COG1396	sequence-specific DNA binding
I6I48_15505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_15510	COG0765	amino acid transport
I6I48_15515	COG1126	abc transporter atp-binding protein
I6I48_15520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_15525	COG0525	valine-tRNA ligase activity
I6I48_15530	COG0105	UTP biosynthetic process
I6I48_15535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I48_15555	COG2976	Protein conserved in bacteria
I6I48_15560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I48_15565	COG1160	GTP binding
I6I48_15570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I48_15575	COG1923	regulation of RNA biosynthetic process
I6I48_15580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I48_15585	COG0330	HflC and HflK could
I6I48_15590	COG0330	HflC and HflK could
I6I48_15595	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6I48_15600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I48_15605	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6I48_15610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I48_15620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I48_15630	COG0438	transferase activity, transferring glycosyl groups
I6I48_15640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I48_15640	COG2755	lipolytic protein G-D-S-L family
I6I48_15665	COG1475	DNA binding
I6I48_15675	COG3723	Recombinational DNA repair protein, rece pathway
I6I48_15680	COG5377	YqaJ viral recombinase family
I6I48_15755	COG2433	Pfam Transposase IS66
I6I48_15815	COG5410	chromosome segregation
I6I48_15825	COG2369	cell adhesion
I6I48_16000	COG4964	Belongs to the GSP D family
I6I48_16030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I48_16040	COG1295	ribonuclease BN
I6I48_16050	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I48_16075	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I48_16170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_16175	COG2274	protein secretion by the type I secretion system
I6I48_16185	COG1538	Outer membrane efflux protein
I6I48_16205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I48_16215	COG0101	tRNA pseudouridine synthase activity
I6I48_16220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6I48_16245	COG0596	Alpha beta hydrolase
I6I48_16280	COG0129	dihydroxy-acid dehydratase activity
I6I48_16285	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_16290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_16295	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I48_16300	COG1609	Transcriptional regulator
I6I48_16320	COG4172	Belongs to the ABC transporter superfamily
I6I48_16325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_16330	COG0601	transmembrane transport
I6I48_16340	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_16370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I48_16375	COG2197	response regulator
I6I48_16385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I48_16390	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I48_16405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I48_16410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I48_16415	COG0004	ammonium transporteR
I6I48_16420	COG0347	Belongs to the P(II) protein family
I6I48_16430	COG2960	long-chain fatty acid transporting porin activity
I6I48_16440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I48_16445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I48_16450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I48_16455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I48_16455	COG0072	phenylalanine-tRNA ligase activity
I6I48_16485	COG2814	Major facilitator Superfamily
I6I48_16510	COG0384	phenazine biosynthesis protein PhzF
I6I48_16515	COG0456	acetyltransferase
I6I48_16550	COG1522	sequence-specific DNA binding
I6I48_16580	COG0583	DNA-binding transcription factor activity
I6I48_16585	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_16610	COG1116	anion transmembrane transporter activity
I6I48_16640	COG5265	(ABC) transporter
I6I48_16645	COG0656	L-ascorbic acid biosynthetic process
I6I48_16660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I48_16670	COG4977	sequence-specific DNA binding
I6I48_16670	COG1917	Cupin 2, conserved barrel domain protein
I6I48_16675	COG2223	nitrite transmembrane transporter activity
I6I48_16685	COG1215	transferase activity, transferring glycosyl groups
I6I48_16690	COG1649	PFAM Uncharacterised BCR, COG1649
I6I48_16690	COG0726	polysaccharide deacetylase
I6I48_16695	COG0457	Tetratricopeptide repeat
I6I48_16725	COG1610	YqeY-like protein
I6I48_16730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I48_16735	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_16775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I48_16785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I48_16790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I48_16820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_16825	COG0697	spore germination
I6I48_16830	COG0506	proline dehydrogenase activity
I6I48_16850	COG0583	DNA-binding transcription factor activity
I6I48_16855	COG0583	DNA-binding transcription factor activity
I6I48_16860	COG0625	glutathione transferase activity
I6I48_16875	COG2814	Major facilitator Superfamily
I6I48_16880	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I48_16895	COG1960	acyl-CoA dehydrogenase activity
I6I48_16900	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_16940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I48_16950	COG3245	cytochrome
I6I48_16955	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I48_16970	COG1280	lysine exporter protein (LysE YggA)
I6I48_16985	COG0697	spore germination
I6I48_16990	COG0697	spore germination
I6I48_17005	COG0534	Mate efflux family protein
I6I48_17010	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I48_17015	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_17025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I48_17030	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I48_17040	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_17075	COG2207	Transcriptional regulator
I6I48_17090	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_17095	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_17100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I48_17105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I48_17115	COG1304	FMN binding
I6I48_17165	COG3088	subunit of a heme lyase
I6I48_17170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_17180	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I48_17200	COG4133	protoheme IX ABC transporter activity
I6I48_17220	COG3381	protein complex oligomerization
I6I48_17240	COG4235	cytochrome complex assembly
I6I48_17250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_17260	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I48_17280	COG4133	protoheme IX ABC transporter activity
I6I48_17285	COG3005	denitrification pathway
I6I48_17290	COG3043	anaerobic respiration
I6I48_17310	COG3246	L-lysine catabolic process to acetate
I6I48_17315	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_17320	COG0583	DNA-binding transcription factor activity
I6I48_17330	COG0129	dihydroxy-acid dehydratase activity
I6I48_17335	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_17340	COG5001	Diguanylate cyclase
I6I48_17345	COG1024	Enoyl-CoA hydratase
I6I48_17375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_17385	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6I48_17390	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_17395	COG0583	DNA-binding transcription factor activity
I6I48_17400	COG2610	gluconate transmembrane transporter activity
I6I48_17440	COG0235	Class ii aldolase
I6I48_17445	COG0477	Major facilitator Superfamily
I6I48_17460	COG2188	Transcriptional regulator
I6I48_17465	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_17505	COG1280	lysine exporter protein (LysE YggA)
I6I48_17510	COG5265	(ABC) transporter
I6I48_17520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_17535	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_17540	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_17575	COG0583	DNA-binding transcription factor activity
I6I48_17585	COG0583	DNA-binding transcription factor activity
I6I48_17595	COG0583	DNA-binding transcription factor activity
I6I48_17620	COG2226	methyltransferase
I6I48_17630	COG2814	Major facilitator Superfamily
I6I48_17635	COG0154	amidase activity
I6I48_17685	COG2070	2-Nitropropane dioxygenase
I6I48_17730	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_17740	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_17745	COG0307	riboflavin synthase, alpha
I6I48_17755	COG2271	Major facilitator Superfamily
I6I48_17765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I48_17775	COG0789	Transcriptional regulator
I6I48_17800	COG4774	siderophore transport
I6I48_17810	COG0022	dehydrogenase e1 component
I6I48_17830	COG1724	mRNA binding
I6I48_17835	COG1598	PFAM Uncharacterised protein family UPF0150
I6I48_17840	COG0165	Argininosuccinate lyase
I6I48_17845	COG0668	transmembrane transport
I6I48_17915	COG2165	general secretion pathway protein
I6I48_17945	COG0583	DNA-binding transcription factor activity
I6I48_17955	COG0747	negative chemotaxis
I6I48_17960	COG0601	transmembrane transport
I6I48_17965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_17970	COG4172	Belongs to the ABC transporter superfamily
I6I48_17975	COG4681	YaeQ
I6I48_17990	COG0477	Major facilitator Superfamily
I6I48_17995	COG3161	chorismate lyase activity
I6I48_18000	COG1187	pseudouridine synthase activity
I6I48_18005	COG0583	DNA-binding transcription factor activity
I6I48_18030	COG1999	signal sequence binding
I6I48_18040	COG0339	signal peptide processing
I6I48_18045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I48_18050	COG4566	intracellular signal transduction
I6I48_18060	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I48_18065	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I48_18070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I48_18080	COG0583	DNA-binding transcription factor activity
I6I48_18105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I48_18110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I48_18120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I48_18130	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I6I48_18140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I48_18155	COG1191	sigma factor activity
I6I48_18175	COG1360	Flagellar Motor Protein
I6I48_18180	COG0745	RESPONSE REGULATOR receiver
I6I48_18190	COG0835	chemotaxis
I6I48_18195	COG0840	transmembrane signaling receptor activity
I6I48_18200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I48_18205	COG2201	protein-glutamate methylesterase activity
I6I48_18210	COG0745	RESPONSE REGULATOR receiver
I6I48_18215	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6I48_18220	COG0840	transmembrane signaling receptor activity
I6I48_18245	COG2747	anti-sigma28 factor FlgM
I6I48_18255	COG1815	bacterial-type flagellum-dependent cell motility
I6I48_18260	COG1558	bacterial-type flagellum-dependent cell motility
I6I48_18275	COG4787	bacterial-type flagellum-dependent cell motility
I6I48_18310	COG0840	transmembrane signaling receptor activity
I6I48_18325	COG0840	transmembrane signaling receptor activity
I6I48_18330	COG0840	transmembrane signaling receptor activity
I6I48_18365	COG1580	Controls the rotational direction of flagella during chemotaxis
I6I48_18390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I48_18395	COG1766	The M ring may be actively involved in energy transduction
I6I48_18400	COG1677	Flagellar hook-basal body complex protein FliE
I6I48_18410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I48_18430	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6I48_18435	COG1334	flagellar protein FlaG
I6I48_18440	COG1414	Transcriptional regulator
I6I48_18450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_18455	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_18465	COG0285	dihydrofolate synthase activity
I6I48_18485	COG1451	nucleotide metabolic process
I6I48_18490	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I48_18500	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I48_18505	COG0024	Methionine aminopeptidase
I6I48_18510	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I48_18515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I48_18520	COG0528	UMP kinase activity
I6I48_18525	COG0233	cytoplasmic translational termination
I6I48_18530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I48_18535	COG0575	Belongs to the CDS family
I6I48_18540	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I48_18545	COG0750	zinc metalloprotease
I6I48_18550	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I48_18555	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6I48_18560	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I48_18565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I48_18580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I48_18585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I48_18605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I48_18605	COG2169	Transcriptional regulator
I6I48_18610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I48_18610	COG0519	Catalyzes the synthesis of GMP from XMP
I6I48_18630	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I48_18635	COG2867	negative regulation of translational initiation
I6I48_18640	COG2914	Belongs to the UPF0125 (RnfH) family
I6I48_18650	COG1024	Enoyl-CoA hydratase
I6I48_18650	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_18680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I48_18685	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I48_18690	COG0084	hydrolase, TatD family'
I6I48_18705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_18710	COG0765	amino acid transport
I6I48_18715	COG1126	abc transporter atp-binding protein
I6I48_18720	COG0010	Belongs to the arginase family
I6I48_18730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I48_18740	COG0095	Lipoate-protein ligase
I6I48_18755	COG0625	glutathione transferase activity
I6I48_18765	COG1522	sequence-specific DNA binding
I6I48_18770	COG0386	Belongs to the glutathione peroxidase family
I6I48_18775	COG2814	Major facilitator Superfamily
I6I48_18795	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I48_18805	COG0840	transmembrane signaling receptor activity
I6I48_18815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_18850	COG1902	pentaerythritol trinitrate reductase activity
I6I48_18880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I48_18895	COG0842	Transport permease protein
I6I48_18900	COG1131	(ABC) transporter
I6I48_18915	COG2130	NADP-dependent
I6I48_18940	COG3842	ATPase activity
I6I48_18945	COG3842	ATPase activity
I6I48_18955	COG0395	ABC-type sugar transport system, permease component
I6I48_19000	COG0346	lactoylglutathione lyase activity
I6I48_19005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_19025	COG3634	alkyl hydroperoxide reductase activity
I6I48_19030	COG1959	2 iron, 2 sulfur cluster binding
I6I48_19035	COG1960	acyl-CoA dehydrogenase activity
I6I48_19070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_19075	COG0420	3'-5' exonuclease activity
I6I48_19105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I48_19105	COG2111	Na H antiporter
I6I48_19110	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I48_19115	COG0651	ATP synthesis coupled electron transport
I6I48_19120	COG1863	multisubunit Na H antiporter MnhE subunit
I6I48_19125	COG2212	antiporter activity
I6I48_19130	COG1320	monovalent cation:proton antiporter activity
I6I48_19150	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6I48_19155	COG0488	(ABC) transporter
I6I48_19190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_19195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I48_19205	COG2252	PERMEase
I6I48_19210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I48_19215	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I48_19250	COG0583	DNA-binding transcription factor activity
I6I48_19255	COG2814	Major facilitator Superfamily
I6I48_19260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I48_19265	COG0789	Transcriptional regulator
I6I48_19280	COG0678	peroxiredoxin activity
I6I48_19280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I48_19290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I48_19295	COG0584	glycerophosphoryl diester phosphodiesterase
I6I48_19305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I48_19315	COG4181	ATPase activity
I6I48_19325	COG1178	ABC-type Fe3 transport system permease component
I6I48_19330	COG3842	ATPase activity
I6I48_19335	COG0583	DNA-binding transcription factor activity
I6I48_19340	COG0560	Phosphoserine phosphatase
I6I48_19355	COG0583	DNA-binding transcription factor activity
I6I48_19370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_19385	COG0583	DNA-binding transcription factor activity
I6I48_19390	COG4336	lyase activity
I6I48_19420	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_19440	COG2816	NAD+ diphosphatase activity
I6I48_19465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_19470	COG0765	amino acid transport
I6I48_19475	COG1126	abc transporter atp-binding protein
I6I48_19480	COG1335	isochorismatase
I6I48_19490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I48_19495	COG1758	RNA polymerase activity
I6I48_19500	COG0194	GDP metabolic process
I6I48_19505	COG3258	Cytochrome c
I6I48_19510	COG2863	cytochrome
I6I48_19515	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_19520	COG0791	NLP P60 protein
I6I48_19535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I48_19540	COG0833	amino acid
I6I48_19545	COG1561	YicC-like family, N-terminal region
I6I48_19550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I48_19560	COG1960	acyl-CoA dehydrogenase activity
I6I48_19575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I48_19580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I48_19585	COG0174	glutamine synthetase
I6I48_19595	COG2204	response regulator
I6I48_19600	COG0583	DNA-binding transcription factor activity
I6I48_19605	COG1741	Belongs to the pirin family
I6I48_19610	COG1741	Belongs to the pirin family
I6I48_19615	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6I48_19620	COG1690	Belongs to the RtcB family
I6I48_19625	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_19630	COG3842	ATPase activity
I6I48_19635	COG4149	molybdate abc transporter
I6I48_19640	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I48_19650	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_19665	COG0583	DNA-binding transcription factor activity
I6I48_19675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I48_19685	COG0783	Belongs to the Dps family
I6I48_19695	COG0457	Tetratricopeptide repeat
I6I48_19700	COG0438	transferase activity, transferring glycosyl groups
I6I48_19725	COG4783	chaperone-mediated protein folding
I6I48_19725	COG1560	Kdo2-lipid A biosynthetic process
I6I48_19730	COG3866	Pectate lyase
I6I48_19745	COG0745	RESPONSE REGULATOR receiver
I6I48_19750	COG2205	protein histidine kinase activity
I6I48_19765	COG3842	ATPase activity
I6I48_19770	COG0395	ABC-type sugar transport system, permease component
I6I48_19775	COG1175	transmembrane transport
I6I48_19780	COG1653	transport
I6I48_19790	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I48_19805	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_19830	COG1794	racemase activity, acting on amino acids and derivatives
I6I48_19835	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I48_19845	COG0583	DNA-binding transcription factor activity
I6I48_19850	COG0625	glutathione transferase activity
I6I48_19855	COG2133	pyrroloquinoline quinone binding
I6I48_19865	COG0697	spore germination
I6I48_19870	COG2363	Small membrane protein
I6I48_19895	COG0010	Belongs to the arginase family
I6I48_19900	COG1464	Belongs to the NlpA lipoprotein family
I6I48_19910	COG2814	Major facilitator Superfamily
I6I48_19920	COG1408	metallophosphoesterase
I6I48_19930	COG0688	phosphatidylethanolamine metabolic process
I6I48_19935	COG0488	(ABC) transporter
I6I48_19960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_19965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I48_19970	COG5001	Diguanylate cyclase
I6I48_19970	COG3300	MHYT domain
I6I48_19985	COG2814	Major facilitator Superfamily
I6I48_20010	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I48_20015	COG2204	response regulator
I6I48_20050	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_20070	COG0693	protein deglycase activity
I6I48_20090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I48_20105	COG3300	MHYT domain
I6I48_20105	COG5001	Diguanylate cyclase
I6I48_20120	COG4774	siderophore transport
I6I48_20155	COG1253	flavin adenine dinucleotide binding
I6I48_20170	COG2205	protein histidine kinase activity
I6I48_20335	COG0789	Transcriptional regulator
I6I48_20345	COG3706	GGDEF domain
I6I48_20375	COG1116	anion transmembrane transporter activity
I6I48_20380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_20385	COG4521	taurine ABC transporter
I6I48_20405	COG0793	Belongs to the peptidase S41A family
I6I48_20425	COG0628	permease
I6I48_20435	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6I48_20450	COG0531	amino acid
I6I48_20460	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I48_20465	COG4608	Belongs to the ABC transporter superfamily
I6I48_20470	COG0444	Belongs to the ABC transporter superfamily
I6I48_20480	COG0601	transmembrane transport
I6I48_20485	COG0747	negative chemotaxis
I6I48_20495	COG0251	oxidation-reduction process
I6I48_20515	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I48_20530	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6I48_20545	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I48_20555	COG3971	2-oxopent-4-enoate hydratase activity
I6I48_20585	COG0625	glutathione transferase activity
I6I48_20600	COG0477	Major facilitator Superfamily
I6I48_20610	COG0579	oxidoreductase
I6I48_20625	COG0625	glutathione transferase activity
I6I48_20640	COG0431	NADPH-dependent FMN reductase
I6I48_20650	COG0798	PFAM Bile acid sodium symporter
I6I48_20660	COG0640	Transcriptional regulator
I6I48_20670	COG0668	transmembrane transport
I6I48_20690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I48_20695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_20715	COG0583	DNA-binding transcription factor activity
I6I48_20720	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6I48_20725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I48_20730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I48_20735	COG1045	serine acetyltransferase
I6I48_20745	COG2957	Belongs to the agmatine deiminase family
I6I48_20750	COG0583	DNA-binding transcription factor activity
I6I48_20770	COG1126	abc transporter atp-binding protein
I6I48_20775	COG0765	amino acid transport
I6I48_20780	COG4597	amino acid ABC transporter
I6I48_20785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_20790	COG0626	cystathionine gamma-synthase activity
I6I48_20795	COG0583	DNA-binding transcription factor activity
I6I48_20815	COG0444	Belongs to the ABC transporter superfamily
I6I48_20820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_20825	COG0601	transmembrane transport
I6I48_20830	COG0747	negative chemotaxis
I6I48_20840	COG0583	DNA-binding transcription factor activity
I6I48_20845	COG1335	isochorismatase
I6I48_20850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I48_20860	COG2358	TRAP transporter, solute receptor (TAXI family
I6I48_20865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_20870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_20880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I48_20885	COG0519	Catalyzes the synthesis of GMP from XMP
I6I48_20885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I48_20895	COG1276	copper resistance
I6I48_20915	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_20920	COG3386	PFAM SMP-30 Gluconolaconase
I6I48_20925	COG2721	sulfolactate sulfo-lyase activity
I6I48_20940	COG0642	Histidine kinase
I6I48_20945	COG0745	RESPONSE REGULATOR receiver
I6I48_20955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_20960	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I6I48_20965	COG3842	ATPase activity
I6I48_20970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I48_20985	COG0586	Pfam SNARE associated Golgi protein
I6I48_20990	COG0390	transport system, permease component
I6I48_21000	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6I48_21045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_21050	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_21055	COG1120	ATPase activity
I6I48_21060	COG1126	abc transporter atp-binding protein
I6I48_21065	COG0765	amino acid transport
I6I48_21070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_21075	COG2070	2-Nitropropane dioxygenase
I6I48_21080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_21090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I48_21115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I48_21120	COG0583	DNA-binding transcription factor activity
I6I48_21130	COG1846	Transcriptional regulator
I6I48_21140	COG4191	Histidine kinase
I6I48_21145	COG4566	intracellular signal transduction
I6I48_21185	COG0583	DNA-binding transcription factor activity
I6I48_21205	COG1126	abc transporter atp-binding protein
I6I48_21215	COG0765	amino acid transport
I6I48_21220	COG0436	Aminotransferase
I6I48_21245	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6I48_21270	COG0251	oxidation-reduction process
I6I48_21285	COG4106	trans-aconitate 2-methyltransferase activity
I6I48_21310	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_21320	COG1802	Transcriptional regulator
I6I48_21325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_21340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I48_21365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_21370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I48_21375	COG1116	anion transmembrane transporter activity
I6I48_21410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_21415	COG4597	amino acid ABC transporter
I6I48_21420	COG3154	lipid carrier protein
I6I48_21425	COG0826	peptidase U32
I6I48_21430	COG0826	peptidase U32
I6I48_21435	COG2197	response regulator
I6I48_21440	COG3850	Histidine kinase
I6I48_21445	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6I48_21450	COG0288	reversible hydration of carbon dioxide
I6I48_21455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I48_21460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I48_21465	COG2181	nitrate reductase activity
I6I48_21470	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6I48_21475	COG1140	nitrate reductase beta subunit
I6I48_21480	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6I48_21485	COG2223	nitrite transmembrane transporter activity
I6I48_21530	COG0583	DNA-binding transcription factor activity
I6I48_21540	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_21570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_21590	COG2070	2-Nitropropane dioxygenase
I6I48_21605	COG5002	protein histidine kinase activity
I6I48_21610	COG0745	RESPONSE REGULATOR receiver
I6I48_21615	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6I48_21620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I48_21630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I48_21635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I48_21650	COG0783	Belongs to the Dps family
I6I48_21680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_21685	COG0697	spore germination
I6I48_21690	COG2879	small protein
I6I48_21695	COG1966	Carbon starvation protein
I6I48_21720	COG0583	DNA-binding transcription factor activity
I6I48_21725	COG4521	taurine ABC transporter
I6I48_21730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I48_21735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_21750	COG2274	protein secretion by the type I secretion system
I6I48_21755	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I48_21765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_21780	COG0235	Class ii aldolase
I6I48_21785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_21800	COG1228	amidohydrolase
I6I48_21805	COG4172	Belongs to the ABC transporter superfamily
I6I48_21810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_21815	COG0601	transmembrane transport
I6I48_21820	COG0747	negative chemotaxis
I6I48_21835	COG1414	Transcriptional regulator
I6I48_21840	COG0513	Belongs to the DEAD box helicase family
I6I48_21845	COG0602	queuosine metabolic process
I6I48_21850	COG0720	synthase
I6I48_21860	COG1289	transmembrane transporter activity
I6I48_21870	COG1566	PFAM secretion protein HlyD family protein
I6I48_21885	COG0028	Belongs to the TPP enzyme family
I6I48_21895	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_21905	COG0400	carboxylic ester hydrolase activity
I6I48_21910	COG0833	amino acid
I6I48_21930	COG0587	DNA-directed DNA polymerase activity
I6I48_21950	COG0667	Aldo Keto reductase
I6I48_21960	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I48_21970	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_21975	COG0583	DNA-binding transcription factor activity
I6I48_22015	COG3038	cytochrome b561
I6I48_22040	COG0840	transmembrane signaling receptor activity
I6I48_22120	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6I48_22140	COG4774	siderophore transport
I6I48_22145	COG2345	Transcriptional regulator
I6I48_22155	COG1414	Transcriptional regulator
I6I48_22165	COG0477	Major facilitator Superfamily
I6I48_22170	COG0667	Aldo Keto reductase
I6I48_22180	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_22185	COG1309	transcriptional regulator
I6I48_22205	COG1683	Conserved Protein
I6I48_22215	COG2207	Transcriptional regulator
I6I48_22235	COG3047	cAMP biosynthetic process
I6I48_22235	COG2885	chlorophyll binding
I6I48_22250	COG3795	YCII-related domain
I6I48_22255	COG3795	YCII-related domain
I6I48_22275	COG0697	spore germination
I6I48_22285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I48_22295	COG0583	DNA-binding transcription factor activity
I6I48_22330	COG1846	Transcriptional regulator
I6I48_22335	COG3541	Predicted nucleotidyltransferase
I6I48_22345	COG1414	Transcriptional regulator
I6I48_22350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I48_22370	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I48_22375	COG3971	2-oxopent-4-enoate hydratase activity
I6I48_22395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_22450	COG3210	domain, Protein
I6I48_22450	COG3210	domain, Protein
I6I48_22475	COG1360	Flagellar Motor Protein
I6I48_22485	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I6I48_22680	COG0625	glutathione transferase activity
I6I48_22685	COG2032	superoxide dismutase activity
I6I48_22690	COG2733	membrane
I6I48_22700	COG0148	phosphopyruvate hydratase activity
I6I48_22725	COG0583	DNA-binding transcription factor activity
I6I48_22730	COG1024	Enoyl-CoA hydratase
I6I48_22730	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_22735	COG0183	Belongs to the thiolase family
I6I48_22740	COG1960	acyl-CoA dehydrogenase activity
I6I48_22745	COG1960	acyl-CoA dehydrogenase activity
I6I48_22750	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_22760	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I48_22775	COG0583	DNA-binding transcription factor activity
I6I48_22790	COG4771	TonB-dependent receptor
I6I48_22795	COG2814	Major facilitator Superfamily
I6I48_22800	COG1846	Transcriptional regulator
I6I48_22805	COG0477	Major facilitator Superfamily
I6I48_22820	COG2080	2 iron, 2 sulfur cluster binding
I6I48_22830	COG0596	Alpha beta hydrolase
I6I48_22835	COG2309	aminopeptidase activity
I6I48_22840	COG1335	isochorismatase
I6I48_22845	COG2010	Cytochrome c
I6I48_22845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I48_22855	COG1522	sequence-specific DNA binding
I6I48_22860	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_22865	COG3842	ATPase activity
I6I48_22870	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I48_22875	COG4149	molybdate abc transporter
I6I48_22880	COG5001	Diguanylate cyclase
I6I48_22880	COG4251	negative regulation of phosphorylation
I6I48_22880	COG3706	GGDEF domain
I6I48_22880	COG2203	Gaf domain
I6I48_22885	COG2201	protein-glutamate methylesterase activity
I6I48_22910	COG0840	transmembrane signaling receptor activity
I6I48_22930	COG0583	DNA-binding transcription factor activity
I6I48_22960	COG0456	acetyltransferase
I6I48_22975	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_23005	COG2188	Transcriptional regulator
I6I48_23010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I48_23015	COG1070	Carbohydrate kinase
I6I48_23025	COG1129	ABC transporter
I6I48_23030	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I48_23035	COG0667	Aldo Keto reductase
I6I48_23045	COG3591	Belongs to the peptidase S1B family
I6I48_23045	COG1864	DNA RNA non-specific endonuclease
I6I48_23085	COG0165	Argininosuccinate lyase
I6I48_23100	COG0583	DNA-binding transcription factor activity
I6I48_23115	COG2205	protein histidine kinase activity
I6I48_23135	COG2207	Transcriptional regulator
I6I48_23140	COG4221	oxidoreductase activity
I6I48_23145	COG2207	Transcriptional regulator
I6I48_23170	COG0640	Transcriptional regulator
I6I48_23175	COG0640	Transcriptional regulator
I6I48_23185	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I48_23190	COG0583	DNA-binding transcription factor activity
I6I48_23195	COG0431	NADPH-dependent FMN reductase
I6I48_23225	COG4264	IucA IucC family
I6I48_23255	COG5002	protein histidine kinase activity
I6I48_23265	COG0519	Catalyzes the synthesis of GMP from XMP
I6I48_23265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I48_23295	COG0583	DNA-binding transcription factor activity
I6I48_23305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I48_23325	COG0583	DNA-binding transcription factor activity
I6I48_23330	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_23375	COG2072	flavoprotein involved in K transport
I6I48_23380	COG0601	transmembrane transport
I6I48_23385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_23395	COG4608	Belongs to the ABC transporter superfamily
I6I48_23400	COG0747	negative chemotaxis
I6I48_23430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I48_23460	COG4774	siderophore transport
I6I48_23490	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I48_23515	COG0583	DNA-binding transcription factor activity
I6I48_23560	COG5001	Diguanylate cyclase
I6I48_23565	COG4774	siderophore transport
I6I48_23570	COG4774	siderophore transport
I6I48_23585	COG0583	DNA-binding transcription factor activity
I6I48_23635	COG1953	Uracil, thiamine, allantoin
I6I48_23675	COG0583	DNA-binding transcription factor activity
I6I48_23680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_23680	COG2205	protein histidine kinase activity
I6I48_23680	COG2198	Histidine kinase
I6I48_23680	COG0784	Response regulator, receiver
I6I48_23685	COG2205	protein histidine kinase activity
I6I48_23685	COG3292	Two component regulator propeller
I6I48_23685	COG0745	RESPONSE REGULATOR receiver
I6I48_23710	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_23720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I48_23735	COG0583	DNA-binding transcription factor activity
I6I48_23755	COG0642	Histidine kinase
I6I48_23780	COG1595	DNA-templated transcription, initiation
I6I48_23785	COG3712	iron ion homeostasis
I6I48_23790	COG4774	siderophore transport
I6I48_23795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I48_23795	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I48_23805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_23805	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I48_23810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_23850	COG0613	PHP domain protein
I6I48_23865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I48_23875	COG0583	DNA-binding transcription factor activity
I6I48_23885	COG0583	DNA-binding transcription factor activity
I6I48_23890	COG0477	Major facilitator Superfamily
I6I48_23895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I48_23905	COG0159	tryptophan synthase activity
I6I48_23940	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I48_23950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I48_23955	COG0459	protein refolding
I6I48_23980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I48_23985	COG0714	Associated with various cellular activities
I6I48_24005	COG2304	oxidoreductase activity
I6I48_24020	COG3119	arylsulfatase activity
I6I48_24030	COG1280	lysine exporter protein (LysE YggA)
I6I48_24060	COG0633	Ferredoxin
I6I48_24065	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_24070	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_24080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I48_24120	COG4604	ABC transporter, ATP-binding protein
I6I48_24125	COG4605	iron ion homeostasis
I6I48_24130	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_24135	COG4607	ABC-type enterochelin transport system periplasmic component
I6I48_24140	COG4771	TonB-dependent receptor
I6I48_24145	COG0745	RESPONSE REGULATOR receiver
I6I48_24155	COG0084	hydrolase, TatD family'
I6I48_24160	COG1136	(ABC) transporter
I6I48_24180	COG2271	Major facilitator Superfamily
I6I48_24190	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_24195	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I48_24210	COG3135	benzoate transporter
I6I48_24215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I48_24220	COG1309	transcriptional regulator
I6I48_24225	COG0183	Belongs to the thiolase family
I6I48_24230	COG1022	Amp-dependent synthetase and ligase
I6I48_24260	COG1024	Enoyl-CoA hydratase
I6I48_24345	COG1196	nuclear chromosome segregation
I6I48_24395	COG0740	serine-type endopeptidase activity
I6I48_24400	COG4695	Portal protein
I6I48_24435	COG1598	PFAM Uncharacterised protein family UPF0150
I6I48_24540	COG0592	DNA-directed DNA polymerase activity
I6I48_24560	COG3561	AntA/AntB antirepressor
I6I48_24580	COG0582	viral genome integration into host DNA
I6I48_24590	COG1803	Methylglyoxal synthase
I6I48_24595	COG2975	iron-sulfur cluster assembly
I6I48_24600	COG0633	Ferredoxin
I6I48_24605	COG0443	Heat shock 70 kDa protein
I6I48_24610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I48_24615	COG0316	Belongs to the HesB IscA family
I6I48_24620	COG0822	iron-sulfur transferase activity
I6I48_24625	COG1104	cysteine desulfurase activity
I6I48_24635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I48_24640	COG0556	nucleotide-excision repair
I6I48_24650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I48_24655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I48_24660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I48_24665	COG0740	serine-type endopeptidase activity
I6I48_24670	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I48_24675	COG0501	Belongs to the peptidase M48B family
I6I48_24685	COG1278	Cold shock
I6I48_24695	COG1278	Cold shock
I6I48_24720	COG0251	oxidation-reduction process
I6I48_24730	COG0583	DNA-binding transcription factor activity
I6I48_24765	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6I48_24790	COG0277	FAD linked oxidase domain protein
I6I48_24805	COG2814	Major facilitator Superfamily
I6I48_24840	COG2171	N-acyltransferase activity
I6I48_24850	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I48_24855	COG0488	(ABC) transporter
I6I48_24870	COG4771	TonB-dependent receptor
I6I48_24875	COG4771	TonB-dependent receptor
I6I48_24880	COG4771	TonB-dependent receptor
I6I48_24890	COG1858	cytochrome C peroxidase
I6I48_24900	COG0210	DNA helicase
I6I48_24915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I48_24915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I48_24920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I48_24925	COG0196	riboflavin kinase activity
I6I48_24930	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I48_24935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I48_24940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I48_24990	COG1902	pentaerythritol trinitrate reductase activity
I6I48_24995	COG1126	abc transporter atp-binding protein
I6I48_25000	COG0765	amino acid transport
I6I48_25005	COG0765	amino acid transport
I6I48_25010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_25020	COG2423	ornithine cyclodeaminase activity
I6I48_25025	COG1764	response to oxidative stress
I6I48_25035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I48_25040	COG0625	glutathione transferase activity
I6I48_25050	COG4178	(ABC) transporter
I6I48_25055	COG4771	TonB-dependent receptor
I6I48_25070	COG2271	Major facilitator Superfamily
I6I48_25100	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I48_25100	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I48_25100	COG0506	proline dehydrogenase activity
I6I48_25110	COG3008	intermembrane lipid transfer
I6I48_25115	COG2995	paraquat-inducible protein a
I6I48_25125	COG4953	penicillin-binding protein 1C
I6I48_25130	COG2373	Large extracellular alpha-helical protein
I6I48_25135	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I48_25140	COG1278	Cold shock
I6I48_25150	COG0183	Belongs to the thiolase family
I6I48_25155	COG0038	chloride channel
I6I48_25165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I48_25175	COG1570	exodeoxyribonuclease VII activity
I6I48_25180	COG0811	peptide transport
I6I48_25190	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I48_25200	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I48_25205	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I48_25210	COG0563	adenylate kinase activity
I6I48_25220	COG0728	peptidoglycan biosynthetic process
I6I48_25230	COG0268	Binds directly to 16S ribosomal RNA
I6I48_25235	COG0583	DNA-binding transcription factor activity
I6I48_25250	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_25255	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I48_25260	COG2186	Transcriptional regulator
I6I48_25270	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_25275	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_25280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I48_25310	COG3384	dioxygenase
I6I48_25315	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_25330	COG3971	2-oxopent-4-enoate hydratase activity
I6I48_25340	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_25345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I48_25350	COG1562	ergosterol biosynthetic process
I6I48_25355	COG1562	ergosterol biosynthetic process
I6I48_25365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I48_25390	COG1477	protein flavinylation
I6I48_25395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I48_25405	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I48_25420	COG5564	TIM-barrel signal transduction protein
I6I48_25425	COG5441	Belongs to the UPF0261 family
I6I48_25450	COG0542	response to heat
I6I48_25460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I48_25470	COG0477	Major facilitator Superfamily
I6I48_25490	COG0494	nUDIX hydrolase
I6I48_25495	COG0583	DNA-binding transcription factor activity
I6I48_25500	COG0443	Heat shock 70 kDa protein
I6I48_25535	COG2814	Major facilitator Superfamily
I6I48_25545	COG3530	Putative quorum-sensing-regulated virulence factor
I6I48_25560	COG0625	glutathione transferase activity
I6I48_25585	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_25595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I48_25655	COG1522	sequence-specific DNA binding
I6I48_25665	COG4172	Belongs to the ABC transporter superfamily
I6I48_25680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_25690	COG0519	Catalyzes the synthesis of GMP from XMP
I6I48_25710	COG1595	DNA-templated transcription, initiation
I6I48_25730	COG0519	Catalyzes the synthesis of GMP from XMP
I6I48_25740	COG2951	lytic endotransglycosylase activity
I6I48_25755	COG0583	DNA-binding transcription factor activity
I6I48_25765	COG2272	Belongs to the type-B carboxylesterase lipase family
I6I48_25770	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_25775	COG1309	transcriptional regulator
I6I48_25785	COG1473	amidohydrolase
I6I48_25790	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_25805	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6I48_25820	COG3618	amidohydrolase
I6I48_25825	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_25860	COG2011	ABC-type metal ion transport system permease component
I6I48_25865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I48_25870	COG1464	Belongs to the NlpA lipoprotein family
I6I48_25880	COG2814	Major facilitator Superfamily
I6I48_25890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I48_25895	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_25935	COG2837	iron assimilation
I6I48_25945	COG0583	DNA-binding transcription factor activity
I6I48_25950	COG2814	Major facilitator Superfamily
I6I48_25955	COG2169	Transcriptional regulator
I6I48_25985	COG1272	protein, Hemolysin III
I6I48_25995	COG1278	Cold shock
I6I48_26025	COG4638	Rieske (2fe-2S)
I6I48_26040	COG3321	synthase
I6I48_26040	COG0604	alcohol dehydrogenase
I6I48_26055	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_26060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_26085	COG0183	Belongs to the thiolase family
I6I48_26100	COG0842	Transport permease protein
I6I48_26105	COG1131	(ABC) transporter
I6I48_26115	COG2197	response regulator
I6I48_26120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I48_26120	COG1116	anion transmembrane transporter activity
I6I48_26125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_26130	COG1116	anion transmembrane transporter activity
I6I48_26135	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6I48_26155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I48_26185	COG0811	peptide transport
I6I48_26245	COG1396	sequence-specific DNA binding
I6I48_26260	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_26305	COG1024	Enoyl-CoA hydratase
I6I48_26320	COG0583	DNA-binding transcription factor activity
I6I48_26375	COG3384	dioxygenase
I6I48_26420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_26425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I48_26430	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6I48_26445	COG1609	Transcriptional regulator
I6I48_26450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_26455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_26465	COG1850	ribulose-bisphosphate carboxylase activity
I6I48_26480	COG0505	Belongs to the CarA family
I6I48_26495	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6I48_26495	COG3608	succinylglutamate desuccinylase aspartoacylase
I6I48_26500	COG0583	DNA-binding transcription factor activity
I6I48_26515	COG1064	alcohol dehydrogenase
I6I48_26520	COG2207	Transcriptional regulator
I6I48_26525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_26615	COG2192	nodulation
I6I48_26625	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I48_26630	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_26635	COG0438	transferase activity, transferring glycosyl groups
I6I48_26645	COG5265	(ABC) transporter
I6I48_26665	COG0668	transmembrane transport
I6I48_26675	COG0166	Belongs to the GPI family
I6I48_26685	COG3685	Protein conserved in bacteria
I6I48_26705	COG0387	Pfam Sodium calcium exchanger
I6I48_26710	COG3568	Endonuclease Exonuclease Phosphatase
I6I48_26715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I48_26720	COG0392	lysyltransferase activity
I6I48_26725	COG0297	glycogen (starch) synthase activity
I6I48_26730	COG0366	Alpha amylase catalytic
I6I48_26735	COG0366	Alpha amylase catalytic
I6I48_26740	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I48_26750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I48_26755	COG1640	4-alpha-glucanotransferase
I6I48_26765	COG1113	amino acid transport
I6I48_26790	COG1058	Belongs to the CinA family
I6I48_26790	COG1546	Belongs to the CinA family
I6I48_26800	COG3852	Histidine kinase
I6I48_26830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I48_26850	COG0477	Major facilitator Superfamily
I6I48_26865	COG5001	Diguanylate cyclase
I6I48_26865	COG1716	ATPase activity
I6I48_26890	COG5295	Hep Hag repeat protein
I6I48_26920	COG1120	ATPase activity
I6I48_26925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_26955	COG0596	Alpha beta hydrolase
I6I48_26970	COG1414	Transcriptional regulator
I6I48_26975	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I48_26980	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_26990	COG2721	sulfolactate sulfo-lyase activity
I6I48_27000	COG0765	amino acid transport
I6I48_27010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_27015	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_27025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I48_27030	COG3958	Transketolase
I6I48_27035	COG3959	Transketolase, thiamine diphosphate binding domain
I6I48_27040	COG1802	Transcriptional regulator
I6I48_27045	COG0371	Dehydrogenase
I6I48_27050	COG3246	L-lysine catabolic process to acetate
I6I48_27055	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_27060	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_27070	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_27085	COG3321	synthase
I6I48_27085	COG0604	alcohol dehydrogenase
I6I48_27085	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_27090	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_27120	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_27130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I48_27155	COG2814	Major facilitator Superfamily
I6I48_27170	COG3384	dioxygenase
I6I48_27185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I48_27240	COG4964	Belongs to the GSP D family
I6I48_27285	COG1846	Transcriptional regulator
I6I48_27290	COG4172	Belongs to the ABC transporter superfamily
I6I48_27295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_27300	COG0601	transmembrane transport
I6I48_27315	COG0598	Magnesium transport protein CorA
I6I48_27335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I48_27350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I48_27355	COG1045	serine acetyltransferase
I6I48_27360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I48_27365	COG0166	Belongs to the GPI family
I6I48_27370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I48_27375	COG3206	protein involved in exopolysaccharide biosynthesis
I6I48_27375	COG0489	protein tyrosine kinase activity
I6I48_27380	COG1596	polysaccharide export
I6I48_27390	COG1051	belongs to the nudix hydrolase family
I6I48_27410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I48_27435	COG0463	Glycosyl transferase, family 2
I6I48_27440	COG0110	maltose O-acetyltransferase activity
I6I48_27445	COG0297	glycogen (starch) synthase activity
I6I48_27450	COG2197	response regulator
I6I48_27455	COG2197	response regulator
I6I48_27465	COG1309	transcriptional regulator
I6I48_27470	COG1960	acyl-CoA dehydrogenase activity
I6I48_27480	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_27480	COG1024	Enoyl-CoA hydratase
I6I48_27490	COG1024	Enoyl-CoA hydratase
I6I48_27490	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_27495	COG0183	Belongs to the thiolase family
I6I48_27510	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_27520	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_27530	COG1132	(ABC) transporter
I6I48_27540	COG3395	kinase activity
I6I48_27545	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I48_27555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I48_27560	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I48_27565	COG1024	Enoyl-CoA hydratase
I6I48_27575	COG1414	Transcriptional regulator
I6I48_27585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I48_27605	COG0583	DNA-binding transcription factor activity
I6I48_27645	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I48_27650	COG1309	transcriptional regulator
I6I48_27660	COG1051	belongs to the nudix hydrolase family
I6I48_27665	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6I48_27675	COG0784	Response regulator, receiver
I6I48_27675	COG2205	protein histidine kinase activity
I6I48_27685	COG0784	Response regulator, receiver
I6I48_27685	COG2205	protein histidine kinase activity
I6I48_27700	COG2863	cytochrome
I6I48_27705	COG3258	Cytochrome c
I6I48_27720	COG3278	Belongs to the heme-copper respiratory oxidase family
I6I48_27740	COG0348	domain, Protein
I6I48_27755	COG0527	aspartate kinase activity
I6I48_27760	COG0037	tRNA processing
I6I48_27765	COG0825	malonyl-CoA metabolic process
I6I48_27775	COG0215	cysteine-tRNA ligase activity
I6I48_27790	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I48_27795	COG1968	undecaprenyl-diphosphatase activity
I6I48_27800	COG1253	flavin adenine dinucleotide binding
I6I48_27815	COG4263	nitrous-oxide reductase activity
I6I48_27830	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6I48_27840	COG1477	protein flavinylation
I6I48_27845	COG4804	nuclease activity
I6I48_27850	COG0483	inositol monophosphate 1-phosphatase activity
I6I48_27870	COG0668	transmembrane transport
I6I48_27910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I48_27915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_27920	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I48_27955	COG3360	Dodecin
I6I48_27965	COG0583	DNA-binding transcription factor activity
I6I48_27970	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_28025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I48_28030	COG2850	peptidyl-arginine hydroxylation
I6I48_28040	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6I48_28045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_28050	COG1994	Peptidase M50
I6I48_28055	COG0009	L-threonylcarbamoyladenylate synthase
I6I48_28060	COG2321	neutral zinc metallopeptidase
I6I48_28120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I48_28125	COG3969	phosphoadenosine phosphosulfate
I6I48_28135	COG1475	DNA binding
I6I48_28140	COG0642	Histidine kinase
I6I48_28160	COG3188	usher protein
I6I48_28165	COG3121	Chaperone
I6I48_28170	COG0840	transmembrane signaling receptor activity
I6I48_28200	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_28205	COG3387	PFAM Glycoside hydrolase 15-related
I6I48_28220	COG0840	transmembrane signaling receptor activity
I6I48_28225	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_28230	COG1280	lysine exporter protein (LysE YggA)
I6I48_28240	COG3246	L-lysine catabolic process to acetate
I6I48_28255	COG0402	S-adenosylhomocysteine deaminase activity
I6I48_28265	COG0582	viral genome integration into host DNA
I6I48_28275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I48_28285	COG1917	Cupin 2, conserved barrel domain protein
I6I48_28285	COG2207	Transcriptional regulator
I6I48_28295	COG2084	Dehydrogenase
I6I48_28315	COG1595	DNA-templated transcription, initiation
I6I48_28330	COG1802	Transcriptional regulator
I6I48_28345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I48_28375	COG2205	protein histidine kinase activity
I6I48_28380	COG1764	response to oxidative stress
I6I48_28395	COG0586	Pfam SNARE associated Golgi protein
I6I48_28400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_28405	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6I48_28460	COG3546	catalase activity
I6I48_28480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_28485	COG0765	amino acid transport
I6I48_28495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_28505	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_28530	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_28550	COG0348	domain, Protein
I6I48_28570	COG3278	Belongs to the heme-copper respiratory oxidase family
I6I48_28585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I48_28590	COG0156	8-amino-7-oxononanoate synthase activity
I6I48_28615	COG2224	Isocitrate lyase
I6I48_28620	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I48_28620	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I48_28625	COG1858	cytochrome C peroxidase
I6I48_28630	COG0583	DNA-binding transcription factor activity
I6I48_28635	COG0473	3-isopropylmalate dehydrogenase activity
I6I48_28645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I48_28660	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I48_28665	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I48_28675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I48_28680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_28705	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6I48_28710	COG4149	molybdate abc transporter
I6I48_28715	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I48_28720	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6I48_28745	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I48_28755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_28765	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6I48_28775	COG0667	Aldo Keto reductase
I6I48_28785	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_28790	COG1024	Enoyl-CoA hydratase
I6I48_28800	COG1802	Transcriptional regulator
I6I48_28810	COG0183	Belongs to the thiolase family
I6I48_28815	COG1960	acyl-CoA dehydrogenase activity
I6I48_28820	COG1960	acyl-CoA dehydrogenase activity
I6I48_28825	COG0583	DNA-binding transcription factor activity
I6I48_28850	COG4213	ABC transporter substrate-binding protein
I6I48_28855	COG1129	ABC transporter
I6I48_28860	COG4214	carbohydrate transport
I6I48_28865	COG2706	6-phosphogluconolactonase activity
I6I48_28870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I48_28885	COG4175	Glycine betaine
I6I48_28885	COG3448	diguanylate cyclase activity
I6I48_28890	COG4176	ABC-type proline glycine betaine transport system permease component
I6I48_28900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I48_28905	COG2814	Major facilitator Superfamily
I6I48_28910	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I48_28915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I48_28930	COG1129	ABC transporter
I6I48_28950	COG1686	Belongs to the peptidase S11 family
I6I48_28965	COG1846	Transcriptional regulator
I6I48_28970	COG2814	Major facilitator Superfamily
I6I48_28975	COG0495	leucyl-tRNA aminoacylation
I6I48_28990	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I48_29010	COG0154	amidase activity
I6I48_29020	COG0477	Major facilitator Superfamily
I6I48_29030	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_29045	COG0583	DNA-binding transcription factor activity
I6I48_29095	COG0583	DNA-binding transcription factor activity
I6I48_29100	COG0427	acetyl-CoA hydrolase
I6I48_29105	COG0583	DNA-binding transcription factor activity
I6I48_29110	COG1511	domain protein
I6I48_29110	COG3264	Mechanosensitive ion channel
I6I48_29160	COG3842	ATPase activity
I6I48_29165	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I48_29170	COG0395	ABC-type sugar transport system, permease component
I6I48_29175	COG3938	Belongs to the proline racemase family
I6I48_29185	COG0517	IMP dehydrogenase activity
I6I48_29215	COG0500	methyltransferase
I6I48_29230	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I6I48_29245	COG0667	Aldo Keto reductase
I6I48_29250	COG2207	Transcriptional regulator
I6I48_29255	COG0583	DNA-binding transcription factor activity
I6I48_29260	COG1335	isochorismatase
I6I48_29270	COG2841	Protein conserved in bacteria
I6I48_29285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I48_29290	COG0438	transferase activity, transferring glycosyl groups
I6I48_29305	COG2003	Belongs to the UPF0758 family
I6I48_29370	COG2433	Pfam Transposase IS66
I6I48_29385	COG2433	Pfam Transposase IS66
I6I48_29400	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_29405	COG0583	DNA-binding transcription factor activity
I6I48_29420	COG0028	Belongs to the TPP enzyme family
I6I48_29450	COG4774	siderophore transport
I6I48_29460	COG1595	DNA-templated transcription, initiation
I6I48_29470	COG0546	phosphoglycolate phosphatase activity
I6I48_29475	COG3842	ATPase activity
I6I48_29480	COG1175	transmembrane transport
I6I48_29485	COG0395	ABC-type sugar transport system, permease component
I6I48_29490	COG1653	transport
I6I48_29510	COG2814	Major facilitator Superfamily
I6I48_29515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I48_29540	COG0248	Ppx GppA phosphatase
I6I48_29550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I48_29560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I48_29565	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I48_29570	COG1534	Rna-binding protein
I6I48_29575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I48_29580	COG0840	transmembrane signaling receptor activity
I6I48_29585	COG2233	PERMEase
I6I48_29605	COG3842	ATPase activity
I6I48_29620	COG4221	oxidoreductase activity
I6I48_29630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I48_29635	COG0505	Belongs to the CarA family
I6I48_29655	COG0745	RESPONSE REGULATOR receiver
I6I48_29670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_29680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I48_29685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_29700	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I48_29710	COG1074	ATP-dependent DNA helicase activity
I6I48_29730	COG2070	2-Nitropropane dioxygenase
I6I48_29750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_29765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I48_29770	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_29785	COG1686	Belongs to the peptidase S11 family
I6I48_29800	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6I48_29805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I48_29810	COG4974	Belongs to the 'phage' integrase family
I6I48_29815	COG0583	DNA-binding transcription factor activity
I6I48_29820	COG0028	Belongs to the TPP enzyme family
I6I48_29860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I48_29905	COG0028	Belongs to the TPP enzyme family
I6I48_29910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_29925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I48_29930	COG1414	Transcriptional regulator
I6I48_29935	COG0009	L-threonylcarbamoyladenylate synthase
I6I48_29940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I48_29945	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I48_29950	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I48_29960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I48_29980	COG1301	dicarboxylic acid transport
I6I48_29990	COG3454	Phosphonate metabolism
I6I48_29995	COG4778	phosphonate C-P lyase system protein PhnL
I6I48_30000	COG4107	phosphonate C-P lyase system protein PhnK
I6I48_30005	COG3627	carbon phosphorus lyase activity
I6I48_30010	COG3626	phosphonate metabolism
I6I48_30015	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6I48_30020	COG3624	Phosphonate C-P lyase system protein PhnG
I6I48_30025	COG2188	Transcriptional regulator
I6I48_30030	COG3454	Phosphonate metabolism
I6I48_30035	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6I48_30040	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6I48_30045	COG0583	DNA-binding transcription factor activity
I6I48_30050	COG0405	Gamma-glutamyltransferase
I6I48_30065	COG3639	organic phosphonate transmembrane transporter activity
I6I48_30070	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6I48_30075	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I48_30085	COG0640	Transcriptional regulator
I6I48_30095	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I48_30105	COG0739	heme binding
I6I48_30115	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I48_30125	COG0306	phosphate transporter
I6I48_30160	COG0625	glutathione transferase activity
I6I48_30180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I48_30185	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I48_30200	COG0126	phosphoglycerate kinase activity
I6I48_30205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I48_30210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I48_30220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I48_30225	COG2732	(Barnase) inhibitor
I6I48_30235	COG0280	phosphate acetyltransferase
I6I48_30235	COG0281	malic enzyme
I6I48_30245	COG0436	Aminotransferase
I6I48_30260	COG0741	lytic transglycosylase activity
I6I48_30265	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6I48_30280	COG4575	ribosome binding
I6I48_30290	COG1116	anion transmembrane transporter activity
I6I48_30295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_30300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I48_30305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I48_30305	COG1648	precorrin-2 dehydrogenase activity
I6I48_30310	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I48_30315	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I48_30330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I48_30340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I48_30345	COG0343	queuine tRNA-ribosyltransferase activity
I6I48_30355	COG3077	Addiction module antitoxin, RelB DinJ family
I6I48_30360	COG1862	Preprotein translocase
I6I48_30365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I48_30370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I48_30390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I48_30400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I48_30405	COG1702	phosphate starvation-inducible protein PhoH
I6I48_30410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I48_30415	COG4535	Mg2 and Co2 transporter CorC
I6I48_30420	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I48_30425	COG0667	Aldo Keto reductase
I6I48_30470	COG0697	spore germination
I6I48_30480	COG0678	peroxiredoxin activity
I6I48_30490	COG0412	Dienelactone hydrolase
I6I48_30500	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I48_30510	COG0314	molybdopterin synthase activity
I6I48_30515	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I48_30520	COG0303	'Molybdopterin
I6I48_30530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I48_30550	COG3383	formate dehydrogenase (NAD+) activity
I6I48_30555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I48_30565	COG2223	nitrite transmembrane transporter activity
I6I48_30590	COG0583	DNA-binding transcription factor activity
I6I48_30595	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I48_30630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I48_30645	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_30665	COG2828	Protein conserved in bacteria
I6I48_30670	COG0583	DNA-binding transcription factor activity
I6I48_30675	COG0456	acetyltransferase
I6I48_30715	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_30740	COG4774	siderophore transport
I6I48_30760	COG4585	Histidine kinase
I6I48_30770	COG0671	phosphoesterase, PA-phosphatase related
I6I48_30785	COG1666	GTP binding
I6I48_30790	COG1120	ATPase activity
I6I48_30795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_30800	COG4558	Periplasmic binding protein
I6I48_30805	COG3720	iron ion transport
I6I48_30815	COG3712	iron ion homeostasis
I6I48_30820	COG1595	DNA-templated transcription, initiation
I6I48_30835	COG2378	regulation of single-species biofilm formation
I6I48_30865	COG1113	amino acid transport
I6I48_30875	COG1522	sequence-specific DNA binding
I6I48_30880	COG1272	protein, Hemolysin III
I6I48_30885	COG3191	aminopeptidase activity
I6I48_30890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_30895	COG0765	amino acid transport
I6I48_30900	COG1126	abc transporter atp-binding protein
I6I48_30905	COG4942	peptidase
I6I48_30925	COG1999	signal sequence binding
I6I48_30945	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6I48_30955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I48_30960	COG1845	cytochrome c oxidase, subunit III
I6I48_30965	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I48_30985	COG4772	TonB-dependent receptor
I6I48_31005	COG0281	malic enzyme
I6I48_31005	COG0280	phosphate acetyltransferase
I6I48_31020	COG0697	spore germination
I6I48_31055	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_31065	COG0583	DNA-binding transcription factor activity
I6I48_31085	COG1396	sequence-specific DNA binding
I6I48_31090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I48_31115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I48_31130	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6I48_31135	COG1285	pathogenesis
I6I48_31140	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_31145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I48_31160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I48_31175	COG3712	iron ion homeostasis
I6I48_31180	COG1595	DNA-templated transcription, initiation
I6I48_31190	COG4221	oxidoreductase activity
I6I48_31195	COG4773	Receptor
I6I48_31215	COG5001	Diguanylate cyclase
I6I48_31220	COG0330	HflC and HflK could
I6I48_31245	COG2807	transmembrane transport
I6I48_31250	COG2207	Transcriptional regulator
I6I48_31255	COG4106	trans-aconitate 2-methyltransferase activity
I6I48_31270	COG0583	DNA-binding transcription factor activity
I6I48_31300	COG3712	iron ion homeostasis
I6I48_31325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I48_31330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_31335	COG0477	Major facilitator Superfamily
I6I48_31340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I48_31345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I48_31350	COG1845	cytochrome c oxidase, subunit III
I6I48_31355	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I48_31365	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_31370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_31380	COG2814	Major facilitator Superfamily
I6I48_31395	COG0625	glutathione transferase activity
I6I48_31455	COG3707	response regulator
I6I48_31460	COG2146	nitrite reductase [NAD(P)H] activity
I6I48_31460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I48_31465	COG2146	nitrite reductase [NAD(P)H] activity
I6I48_31465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I48_31470	COG0243	molybdopterin cofactor binding
I6I48_31480	COG0667	Aldo Keto reductase
I6I48_31495	COG0656	L-ascorbic acid biosynthetic process
I6I48_31500	COG0583	DNA-binding transcription factor activity
I6I48_31505	COG0023	Translation Initiation Factor
I6I48_31515	COG0454	-acetyltransferase
I6I48_31515	COG0456	acetyltransferase
I6I48_31520	COG0583	DNA-binding transcription factor activity
I6I48_31525	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_31550	COG0840	transmembrane signaling receptor activity
I6I48_31555	COG2203	Gaf domain
I6I48_31555	COG2199	diguanylate cyclase activity
I6I48_31560	COG0640	Transcriptional regulator
I6I48_31570	COG0740	serine-type endopeptidase activity
I6I48_31575	COG2814	Major facilitator Superfamily
I6I48_31605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_31615	COG0596	Alpha beta hydrolase
I6I48_31630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I48_31635	COG0583	DNA-binding transcription factor activity
I6I48_31670	COG0028	Belongs to the TPP enzyme family
I6I48_31690	COG1230	cation diffusion facilitator family transporter
I6I48_31710	COG1132	(ABC) transporter
I6I48_31720	COG1201	RNA secondary structure unwinding
I6I48_31725	COG1793	dna ligase
I6I48_31730	COG1793	dna ligase
I6I48_31730	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6I48_31770	COG1960	acyl-CoA dehydrogenase activity
I6I48_31780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_31785	COG0697	spore germination
I6I48_31805	COG0436	Aminotransferase
I6I48_31810	COG0583	DNA-binding transcription factor activity
I6I48_31815	COG0583	DNA-binding transcription factor activity
I6I48_31840	COG0583	DNA-binding transcription factor activity
I6I48_31845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_31850	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_31855	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_31870	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_31915	COG1595	DNA-templated transcription, initiation
I6I48_31930	COG0583	DNA-binding transcription factor activity
I6I48_31935	COG1902	pentaerythritol trinitrate reductase activity
I6I48_31945	COG0251	oxidation-reduction process
I6I48_31965	COG4172	Belongs to the ABC transporter superfamily
I6I48_31990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_32005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_32040	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I48_32045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_32065	COG2433	Pfam Transposase IS66
I6I48_32090	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I48_32095	COG0459	protein refolding
I6I48_32105	COG1846	Transcriptional regulator
I6I48_32125	COG1917	Cupin 2, conserved barrel domain protein
I6I48_32150	COG1137	ATPase activity
I6I48_32160	COG0246	Mannitol dehydrogenase
I6I48_32165	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I48_32170	COG1252	NADH dehydrogenase
I6I48_32175	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I48_32180	COG1546	Belongs to the CinA family
I6I48_32210	COG1280	lysine exporter protein (LysE YggA)