locus-tag class description AL504_00070 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein AL504_00095 ENOG4108RG0 uracil-dna glycosylase AL504_00100 ENOG4105EVZ LysR family transcriptional regulator AL504_00110 ENOG4105C26 Dehydrogenase AL504_00145 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AL504_00150 ENOG4105F8V Hydrolase, tatD family AL504_00155 ENOG410804D Sensor Signal Transduction Histidine Kinase AL504_00160 ENOG4105E3W Two component transcriptional regulator (Winged helix family AL504_00165 ENOG4105D05 Receptor AL504_00175 ENOG4105DHS permease protein AL504_00180 ENOG4105CM4 permease protein AL504_00185 ENOG4108IPW abc transporter atp-binding protein AL504_00190 ENOG4105E0K tonB-dependent siderophore receptor AL504_00205 ENOG4108SF5 RNA Polymerase AL504_00235 ENOG4107XC4 flavin reductase domain protein, FMN-binding AL504_00245 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AL504_00260 ENOG4105ENH Sulfatase AL504_00300 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AL504_00305 ENOG4105E6M Sulphatase-modifying factor protein AL504_00340 ENOG4105JP4 Inner membrane protein yidG AL504_00345 ENOG4105VG5 Membrane AL504_00390 ENOG4105CXG d-lactate dehydrogenase AL504_00395 ENOG4108MGI Transcriptional regulator AL504_00405 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AL504_00410 ENOG4108EC8 DNA internalization-related competence protein ComEC AL504_00415 ENOG4107S4Y M20 DapE family protein YgeY AL504_00420 ENOG4105CSH Transporter AL504_00425 ENOG4105DUM transcriptional regulator, lysR family AL504_00430 ENOG4105YHG TonB family AL504_00435 ENOG4105DND Transcriptional regulator AL504_00445 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AL504_00465 ENOG4105DB7 PHP domain protein AL504_00470 ENOG4108RRZ Transcription elongation factor GreB AL504_00500 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AL504_00505 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL504_00515 ENOG4108ETH Formylglycinamide ribotide synthetase AL504_00520 ENOG4105C8Q Methyl-accepting chemotaxis AL504_00535 ENOG4105XJC Two component transcriptional regulator (Winged helix family AL504_00540 ENOG4105DHQ Histidine kinase AL504_00555 ENOG4107YNJ LysR family Transcriptional regulator AL504_00570 ENOG41082CG Protein CrcB homolog AL504_00580 ENOG4105CHR reductase AL504_00590 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase AL504_00595 ENOG4107YNJ LysR family Transcriptional regulator AL504_00625 ENOG4108RQS Two component transcriptional regulator (Winged helix family AL504_00630 ENOG4105BZU Histidine kinase AL504_00635 ENOG4105CC0 LysR family Transcriptional regulator AL504_00650 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AL504_00670 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AL504_00680 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AL504_00685 ENOG4105C0R drug resistance transporter emrb qaca subfamily AL504_00705 ENOG4105ZRN AL504_00725 ENOG4105CBN LysR family transcriptional regulator AL504_00755 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AL504_00760 ENOG4105BZU Histidine kinase AL504_00770 ENOG4105E0K tonB-dependent siderophore receptor AL504_00800 ENOG4107RT4 flavin reductase domain protein AL504_00815 ENOG4105GAK amidohydrolase 2 AL504_00820 ENOG4107F9Y LysR family transcriptional regulator AL504_00830 ENOG4105CC9 acyl-Coa dehydrogenase AL504_00840 ENOG41060WC Enoyl-CoA hydratase AL504_00870 ENOG4105CNM Receptor AL504_00895 ENOG4105E7U AraC family transcriptional regulator AL504_00900 ENOG4105E0K tonB-dependent siderophore receptor AL504_00945 ENOG4105DG4 malate L-lactate dehydrogenase AL504_00955 ENOG4105F04 LysR family Transcriptional regulator AL504_00970 ENOG4105DEF Extracellular solute-binding protein, family 5 AL504_00975 ENOG4108JQ7 (ABC) transporter AL504_00980 ENOG4105C3U ABC transporter AL504_00985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL504_00990 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL504_00995 ENOG4105E1J oxidoreductase AL504_01005 ENOG4105CEV competence damage-inducible protein AL504_01030 ENOG4105DV0 amidase (EC 3.5.1.4 AL504_01040 ENOG4105BZC d-serine deaminase AL504_01070 ENOG4105C5I Dehydrogenase AL504_01080 ENOG4107RSM transcriptional regulator AL504_01100 ENOG4105F4K antigen 43 AL504_01110 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AL504_01115 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AL504_01145 ENOG4105HEI LysR family (Transcriptional regulator AL504_01175 ENOG4105WAB arsR family transcriptional regulator AL504_01180 ENOG4108VHC Short-chain dehydrogenase reductase Sdr AL504_01205 ENOG41090HR transcriptional regulator AL504_01225 ENOG4105CF7 AraC family transcriptional regulator AL504_01230 ENOG4105EMU Dehydrogenase AL504_01245 ENOG4105D74 hydrolase AL504_01250 ENOG4105E1F short-chain dehydrogenase reductase AL504_01265 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AL504_01270 ENOG4105F9N Major Facilitator Superfamily AL504_01295 ENOG4105R1U AraC Family Transcriptional Regulator AL504_01335 ENOG4108Z6Z Transcriptional regulator AL504_01340 ENOG4105HEI LysR family (Transcriptional regulator AL504_01355 ENOG4106IQC argininosuccinate lyase AL504_01370 ENOG41064T2 transcriptional regulator, lysR family AL504_01385 ENOG4105C0R drug resistance transporter emrb qaca subfamily AL504_01390 ENOG41061GT Aldolase AL504_01395 ENOG4108FN7 Aldo keto reductase AL504_01400 ENOG4105CNN ABC, transporter AL504_01415 ENOG4105CMG Carbohydrate kinase AL504_01425 ENOG4105FDP GntR family transcriptional regulator AL504_01460 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AL504_01470 ENOG4105F2V VRR-NUC domain-containing protein AL504_01475 ENOG4105DVT helicase AL504_01490 ENOG4105CC0 LysR family Transcriptional regulator AL504_01500 ENOG4105DV0 amidase (EC 3.5.1.4 AL504_01505 ENOG4105C8Q Methyl-accepting chemotaxis AL504_01515 ENOG4108KTQ Methyltransferase AL504_01525 ENOG4105CBS Chea signal transduction histidine kinase AL504_01530 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AL504_01540 ENOG4105E0C molybdate abc transporter AL504_01545 ENOG4105C4Y ABC transporter AL504_01550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL504_01555 ENOG4108Z9W Outer membrane porin AL504_01560 ENOG4105F7P transcriptional regulator AsnC family AL504_01570 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AL504_01580 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AL504_01585 ENOG4108UAU isochorismatase AL504_01605 ENOG4108XHQ (2Fe-2S)-binding domain protein AL504_01610 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AL504_01615 ENOG41079KZ Major Facilitator Superfamily AL504_01620 ENOG4108VHT MarR family transcriptional regulator AL504_01625 ENOG4105EYM Major Facilitator superfamily AL504_01630 ENOG4107ZSV Receptor AL504_01645 ENOG4105F04 LysR family Transcriptional regulator AL504_01660 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AL504_01670 ENOG4105DUM transcriptional regulator, lysR family AL504_01675 ENOG4105K6H D-cysteine desulfhydrase AL504_01680 ENOG4105JN3 extra-cytoplasmic solute receptor family protein AL504_01685 ENOG4105CEY Amp-dependent synthetase and ligase AL504_01690 ENOG4105C1G acyl-Coa dehydrogenase AL504_01695 ENOG4105CC9 acyl-Coa dehydrogenase AL504_01700 ENOG4105CHU acetyl-coa acetyltransferase AL504_01705 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL504_01710 ENOG4105CBN LysR family transcriptional regulator AL504_01745 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AL504_01755 ENOG4106BRA Membrane AL504_01760 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AL504_01765 ENOG4108TGY Glutathione S-transferase AL504_01775 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AL504_01920 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL504_01980 ENOG4108ZG0 Ompa motb domain protein AL504_02035 ENOG4105ERH Fumarylacetoacetate hydrolase AL504_02045 ENOG4105KME endoribonuclease L-psp AL504_02055 ENOG4107XC4 flavin reductase domain protein, FMN-binding AL504_02060 ENOG4108K8U Glycerol operon regulatory protein AL504_02070 ENOG410756H nucleotidyltransferase AL504_02075 ENOG41082F9 transcriptional regulator AL504_02085 ENOG4108K3A Glutathione S-transferase AL504_02105 ENOG410849A acetyltransferase, (GNAT) family AL504_02125 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 AL504_02135 ENOG4105DXC membrane AL504_02145 ENOG4105CHP RNA polymerase AL504_02155 ENOG4105GRZ Ycii-related protein AL504_02160 ENOG4105GRZ Ycii-related protein AL504_02180 ENOG4107R0U MotA TolQ exbB proton channel AL504_02195 ENOG4105R1U AraC Family Transcriptional Regulator AL504_02210 ENOG4105HHA aminodeoxychorismate lyase AL504_02215 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AL504_02220 ENOG4105C6E dna polymerase iii AL504_02225 ENOG4105F8V Hydrolase, tatD family AL504_02240 ENOG4106TNF Periplasmic binding protein AL504_02245 ENOG4105E5Q amino acid AbC transporter AL504_02250 ENOG4105CDA abc transporter atp-binding protein AL504_02255 ENOG41088SP formiminoglutamate hydrolase AL504_02265 ENOG4105D82 Glutamate dehydrogenase AL504_02275 ENOG4105DF9 Lipoate-protein, ligase AL504_02290 ENOG4105CYM Glutathione S-transferase AL504_02300 ENOG4108YXU transcriptional regulator AsnC family AL504_02305 ENOG4108V06 Glutathione peroxidase AL504_02310 ENOG4105F27 Major Facilitator AL504_02325 ENOG4105WAP TPR repeat-containing protein AL504_02335 ENOG4107S2N Type III effector Hrp-dependent AL504_02340 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AL504_02350 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AL504_02355 ENOG4105CVP deoxyribo-dipyrimidine photolyase AL504_02360 ENOG410846T CoA-transferase family III AL504_02385 ENOG4105C1J atp-dependent rna helicase AL504_02390 ENOG4108FUF Transcriptional regulator, IclR family AL504_02410 ENOG4105CJP fad dependent oxidoreductase AL504_02415 ENOG4108BMY protease AL504_02415 ENOG4108BMY protease AL504_02440 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AL504_02450 ENOG4106FTQ Taurine ABC transporter, periplasmic AL504_02455 ENOG4105EUJ GTP cyclohydrolase i AL504_02470 ENOG4105D22 carbon starvation protein AL504_02475 ENOG4105VCD cytoplasmic protein AL504_02480 ENOG4105T38 integral membrane protein AL504_02485 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL504_02520 ENOG4107U7B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AL504_02525 ENOG4105E0X reductase AL504_02535 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AL504_02540 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) AL504_02545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL504_02550 ENOG4105BZU Histidine kinase AL504_02555 ENOG4105EA8 2-Nitropropane dioxygenase AL504_02575 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL504_02615 ENOG4105EMY transcriptional regulator AL504_02620 ENOG4105BZS acriflavin resistance protein AL504_02625 ENOG4105BZS acriflavin resistance protein AL504_02635 ENOG4105HEI LysR family (Transcriptional regulator AL504_02660 ENOG4105DQQ Major facilitator superfamily MFS_1 AL504_02665 ENOG4105CRU nitrate reductase, alpha subunit AL504_02670 ENOG4108IUE nitrate reductase beta subunit AL504_02675 ENOG4105R3A Nitrate reductase AL504_02680 ENOG41076YT nitrate reductase, gamma subunit AL504_02685 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AL504_02690 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AL504_02695 ENOG4107B2H carbonic anhydrase AL504_02700 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b AL504_02705 ENOG4105BZU Histidine kinase AL504_02710 ENOG4105WH1 Two component transcriptional regulator luxr family AL504_02715 ENOG4105CFP Peptidase U32 AL504_02720 ENOG4106RZ4 Peptidase U32 AL504_02725 ENOG4105XPQ lipid carrier protein AL504_02735 ENOG4107QXX ABC transporter AL504_02740 ENOG4105C3J Cysteine desulfurase AL504_02770 ENOG4105D7T ABC transporter AL504_02775 ENOG4105I5W Transporter AL504_02780 ENOG4105DG7 nitrate ABC transporter AL504_02810 ENOG4105JSC dimethylmenaquinone methyltransferase AL504_02820 ENOG4105JN3 extra-cytoplasmic solute receptor family protein AL504_02825 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AL504_02830 ENOG4105DRR Transcriptional regulator, GntR family AL504_02840 ENOG4105DTQ mandelate racemase muconate lactonizing AL504_02845 ENOG4108KB2 LysR family Transcriptional regulator AL504_02875 ENOG4105E0K tonB-dependent siderophore receptor AL504_02900 ENOG4108UQ8 endoribonuclease L-psp AL504_02945 ENOG4105EAB amino acid AbC transporter AL504_02950 ENOG4105CQB FAD linked oxidase domain protein AL504_02955 ENOG4105CHM Aminotransferase AL504_02960 ENOG4105E5Q amino acid AbC transporter AL504_02970 ENOG4105CDA abc transporter atp-binding protein AL504_02990 ENOG4107R11 Transcriptional regulator AL504_03055 ENOG4108ZXC Two component transcriptional regulator, luxr family AL504_03060 ENOG4105BZU Histidine kinase AL504_03070 ENOG41067TZ transcriptional regulator, MarR family AL504_03075 ENOG4105CMQ Chloride channel AL504_03080 ENOG4108KXM LysR family Transcriptional regulator AL504_03085 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AL504_03115 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL504_03125 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AL504_03130 ENOG4105EA8 2-Nitropropane dioxygenase AL504_03135 ENOG4105EAB amino acid AbC transporter AL504_03140 ENOG4105E5Q amino acid AbC transporter AL504_03145 ENOG4105CDA abc transporter atp-binding protein AL504_03150 ENOG4108SF5 RNA Polymerase AL504_03155 ENOG4108S3W Anti-feci sigma factor, fecr AL504_03160 ENOG4105E0K tonB-dependent siderophore receptor AL504_03225 ENOG4105E0K tonB-dependent siderophore receptor AL504_03235 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) AL504_03250 ENOG4105IBP Cyclic peptide transporter AL504_03255 ENOG4105E0A ABC, transporter AL504_03260 ENOG4105TVJ transport system, permease AL504_03265 ENOG4105DQ5 transport system permease protein AL504_03270 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AL504_03275 ENOG4105CNM Receptor AL504_03310 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) AL504_03315 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AL504_03325 ENOG4105DQR SNARE associated Golgi AL504_03330 ENOG4105E9K Isocitrate dehydrogenase AL504_03335 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AL504_03340 ENOG4105C7B Threonine dehydratase AL504_03350 ENOG41090JD Blue (Type 1) copper domain protein AL504_03355 ENOG4105EHG Permease protein AL504_03365 ENOG4105ETX regulatoR AL504_03370 ENOG4105ECM Sensor protein basS pmrB AL504_03380 ENOG4105CDA abc transporter atp-binding protein AL504_03385 ENOG4105DRP amino acid AbC transporter AL504_03390 ENOG4105EZ7 amino acid ABC transporter AL504_03395 ENOG4105CHM Aminotransferase AL504_03405 ENOG4105FDP GntR family transcriptional regulator AL504_03425 ENOG4105CTX dehydratase AL504_03455 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AL504_03460 ENOG4105CPU Monooxygenase AL504_03465 ENOG4105D7T ABC transporter AL504_03470 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AL504_03475 ENOG4105DG7 nitrate ABC transporter AL504_03490 ENOG41088CQ domain protein AL504_03495 ENOG4105ECW sulfate abc transporter AL504_03500 ENOG4108I5D sulfate abc transporter AL504_03505 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein AL504_03510 ENOG4105CHJ isochorismatase hydrolase AL504_03515 ENOG4105RQF LysR family Transcriptional regulator AL504_03525 ENOG4105DEF Extracellular solute-binding protein, family 5 AL504_03530 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL504_03535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL504_03540 ENOG4105C3U ABC transporter AL504_03550 ENOG4107RNH Outer membrane receptor FepA AL504_03555 ENOG4105RQF LysR family Transcriptional regulator AL504_03560 ENOG4105C28 cystathionine AL504_03565 ENOG4107QXX ABC transporter AL504_03570 ENOG4105EZ7 amino acid ABC transporter AL504_03575 ENOG4105DRP amino acid AbC transporter AL504_03580 ENOG4105CDA abc transporter atp-binding protein AL504_03600 ENOG4105ETT transcriptional Regulator, LysR family AL504_03605 ENOG4105DWY Agmatine deiminase AL504_03610 ENOG4105DZ0 fad dependent oxidoreductase AL504_03615 ENOG4107RSM transcriptional regulator AL504_03635 ENOG4105CF7 AraC family transcriptional regulator AL504_03640 ENOG4105C26 Dehydrogenase AL504_03650 ENOG4107QM5 aconitate hydratase AL504_03655 ENOG4105CR4 methylisocitrate lyase AL504_03660 ENOG4108JU7 Transcriptional regulator AL504_03680 ENOG4105DUM transcriptional regulator, lysR family AL504_03690 ENOG4105CE1 Ferrous iron transport protein b AL504_03705 ENOG4105KVH Transcriptional regulator AL504_03745 ENOG4105DWT malate dehydrogenase (quinone) AL504_03765 ENOG4105DUM transcriptional regulator, lysR family AL504_03770 ENOG4105CYM Glutathione S-transferase AL504_03855 ENOG4105ERH Fumarylacetoacetate hydrolase AL504_03870 ENOG4105FC8 fad dependent oxidoreductase AL504_03875 ENOG4105KME endoribonuclease L-psp AL504_03920 ENOG4107R7I amino acid AL504_03925 ENOG41089UC methyltransferase, type 11 AL504_03940 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AL504_03945 ENOG4105C28 cystathionine AL504_03950 ENOG4105IPI Membrane AL504_03960 ENOG4108M0I Transcriptional regulator AL504_03965 ENOG4105C5I Dehydrogenase AL504_03990 ENOG4105BZU Histidine kinase AL504_04000 ENOG4108Z4X TRANSCRIPTIONal AL504_04005 ENOG4105BZU Histidine kinase AL504_04025 ENOG4108WWZ General secretion pathway protein J AL504_04030 ENOG4105X5Z General secretion pathway protein I AL504_04035 ENOG4105VWV general secretion pathway protein h AL504_04080 ENOG4108UPW ABC transporter AL504_04085 ENOG4105D7Q type ii secretion system AL504_04090 ENOG4107QHF type ii secretion system protein e AL504_04110 ENOG4108VAU general secretion pathway protein G AL504_04145 ENOG4108FN7 Aldo keto reductase AL504_04150 ENOG410642W LysR family Transcriptional regulator AL504_04165 ENOG4105JJR Histidine kinase AL504_04190 ENOG4105EE5 Membrane protein terC AL504_04205 ENOG4106RE7 Cytochrome AL504_04240 ENOG4105BZU Histidine kinase AL504_04255 ENOG4105C5I Dehydrogenase AL504_04265 ENOG4107R7Y intracellular protease Pfpi family AL504_04285 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AL504_04315 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL504_04320 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL504_04325 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL504_04345 ENOG4107ZSV Receptor AL504_04370 ENOG4105BZ1 (ABC) transporter AL504_04380 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) AL504_04385 ENOG4105D94 Major Facilitator Superfamily AL504_04405 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL504_04410 ENOG4105MWK D-amino acid dehydrogenase, small subunit AL504_04435 ENOG4105C5H ABC transporter AL504_04445 ENOG4105DJ4 phosphatidylserine decarboxylase AL504_04475 ENOG4107RN3 metallophosphoesterase AL504_04485 ENOG4105F27 Major Facilitator AL504_04495 ENOG4105D01 (LipO)protein AL504_04500 ENOG4105CYW agmatinase AL504_04515 ENOG4108EHX EamA-like transporter family AL504_04525 ENOG4105D8V Glucose sorbosone dehydrogenase AL504_04530 ENOG4108K3A Glutathione S-transferase AL504_04535 ENOG4105RQF LysR family Transcriptional regulator AL504_04555 ENOG4108IV0 ABC, transporter AL504_04560 ENOG4105C0Z ABC transporter AL504_04565 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AL504_04570 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_04575 ENOG4105CP9 extracellular ligand-binding receptor AL504_04580 ENOG4105EX9 Membrane AL504_04585 ENOG4105II7 pyrroline-5-carboxylate reductase AL504_04590 ENOG4105BZ7 extracellular solute-binding protein family 1 AL504_04595 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AL504_04605 ENOG4108IJ9 (ABC) transporter AL504_04620 ENOG4105JJR Histidine kinase AL504_04625 ENOG4107EXC regulatoR AL504_04630 ENOG4105CP9 extracellular ligand-binding receptor AL504_04640 ENOG4105DBA pectate lyase AL504_04645 ENOG4106PQC AL504_04670 ENOG4107TAE Glycosyl transferase (Group 1 AL504_04675 ENOG4106EYY AL504_04695 ENOG4105CB5 ATP-dependent DNA helicase recG AL504_04700 ENOG4105KME endoribonuclease L-psp AL504_04715 ENOG4105DND Transcriptional regulator AL504_04735 ENOG4105DP0 ferredoxin-NADP reductase AL504_04745 ENOG4105E0C molybdate abc transporter AL504_04750 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL504_04765 ENOG4108S2Y peptide Chain Release factor AL504_04770 ENOG4105EUB pirin domain protein AL504_04780 ENOG4105EQ1 Transcriptional regulator AL504_04785 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL504_04790 ENOG4105CUX Signal transduction histidine kinase AL504_04795 ENOG4105C5F glutamine synthetase AL504_04800 ENOG4105CSA Coproporphyrinogen iii oxidase AL504_04805 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AL504_04810 ENOG4105BZU Histidine kinase AL504_04815 ENOG4105C1G acyl-Coa dehydrogenase AL504_04825 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AL504_04830 ENOG4105DSJ YicC domain protein AL504_04835 ENOG4108IQI permease AL504_04840 ENOG4105FYV Amp nucleosidase AL504_04850 ENOG4105UGU tonB-dependent Receptor AL504_04855 ENOG4105K4H Nlp p60 protein AL504_04860 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AL504_04870 ENOG4105NQN cytochrome C AL504_04875 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AL504_04880 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AL504_04885 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AL504_04890 ENOG4105ECQ AraC Family Transcriptional Regulator AL504_04895 ENOG4105D3W isochorismatase AL504_04900 ENOG4105CDA abc transporter atp-binding protein AL504_04905 ENOG4105E5Q amino acid AbC transporter AL504_04910 ENOG4107R0W ABC transporter AL504_04930 ENOG4105E09 nadh pyrophosphatase AL504_04945 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL504_04950 ENOG4108Z9W Outer membrane porin AL504_04955 ENOG4108IV0 ABC, transporter AL504_04960 ENOG4105C0Z ABC transporter AL504_04970 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_04980 ENOG4105CFM UPF0317 protein AL504_04985 ENOG4105DND Transcriptional regulator AL504_05000 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL504_05015 ENOG4105DND Transcriptional regulator AL504_05025 ENOG4105RKW reductase (By AL504_05030 ENOG4105EAC phosphoserine phosphatase AL504_05035 ENOG4105ETT transcriptional Regulator, LysR family AL504_05040 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL504_05045 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component AL504_05055 ENOG4108I0Y (ABC) transporter AL504_05060 ENOG4108UJV acyl-CoA thioesterase i AL504_05065 ENOG4105EIN peptidylprolyl cis-trans isomerase AL504_05075 ENOG4107T6V glycerophosphoryl diester phosphodiesterase AL504_05080 ENOG4105D6S protein involved in catabolism of external DNA AL504_05090 ENOG4105C84 Histidine ammonia-lyase AL504_05100 ENOG4105EHV domain protein AL504_05120 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AL504_05140 ENOG4108K5P (LipO)protein AL504_05145 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AL504_05150 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AL504_05155 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AL504_05160 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AL504_05165 ENOG4105C7N Xanthine uracil vitamin C permease AL504_05175 ENOG4105DEN Luciferase family AL504_05180 ENOG41080RH Thioredoxin AL504_05210 ENOG4105F9N Major Facilitator Superfamily AL504_05215 ENOG4105C5H ABC transporter AL504_05220 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AL504_05225 ENOG4108Z6B deaminase AL504_05230 ENOG4106TCE AL504_05240 ENOG4105KJM monovalent cation h antiporter subunit g AL504_05245 ENOG4105W4C monovalent cation H antiporter subunit F AL504_05250 ENOG4105SC1 monovalent cation H antiporter subunit E AL504_05255 ENOG4107R4Z monovalent cation h antiporter subunit d AL504_05260 ENOG4108ZE9 Monovalent cation H antiporter subunit C AL504_05265 ENOG4105D65 subunit l AL504_05310 ENOG4105MWK D-amino acid dehydrogenase, small subunit AL504_05315 ENOG4105EW9 transcriptional regulator AsnC family AL504_05350 ENOG4105C1G acyl-Coa dehydrogenase AL504_05355 ENOG41062ES Transcriptional regulator AL504_05360 ENOG4108JU3 Alkyl hydroperoxide reductase AL504_05385 ENOG4108Z9W Outer membrane porin AL504_05390 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AL504_05430 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component AL504_05440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL504_05445 ENOG4108IJ9 (ABC) transporter AL504_05450 ENOG4105E98 transcriptional regulator DeoR family AL504_05460 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AL504_05470 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AL504_05485 ENOG4105CJ1 ABC, transporter AL504_05490 ENOG4107QWP ABC-2 type transporter AL504_05505 ENOG4108KXH Ybak prolyl-tRNA synthetase associated AL504_05535 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL504_05545 ENOG4108YZN class I peptide chain release factor AL504_05550 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AL504_05565 ENOG4105DSW Fusaric acid resistance protein AL504_05570 ENOG4105ZQC membrane protein AaeX AL504_05575 ENOG4105Y49 secretion protein, HlyD family AL504_05590 ENOG4105C7K acetolactate synthase AL504_05600 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AL504_05610 ENOG4106KED esterase YpfH AL504_05615 ENOG4108IQI permease AL504_05630 ENOG4105C0B DNA polymerase III (alpha subunit) AL504_05645 ENOG4105EQ2 LysR family Transcriptional regulator AL504_05650 ENOG4107S5I aldo keto reductase AL504_05685 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AL504_05690 ENOG4108M0I Transcriptional regulator AL504_05705 ENOG4105DRP amino acid AbC transporter AL504_05710 ENOG4105EAD ABC transporter AL504_05715 ENOG4105EAB amino acid AbC transporter AL504_05720 ENOG4105CHM Aminotransferase AL504_05725 ENOG4105JSC dimethylmenaquinone methyltransferase AL504_05780 ENOG4105C8Q Methyl-accepting chemotaxis AL504_05815 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AL504_05835 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein AL504_05840 ENOG4108IUZ ABC transporter AL504_05850 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_05865 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase AL504_05885 ENOG4105E0K tonB-dependent siderophore receptor AL504_05900 ENOG4108FUF Transcriptional regulator, IclR family AL504_05910 ENOG4105CSH Transporter AL504_05915 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AL504_05920 ENOG4105BZS acriflavin resistance protein AL504_05925 ENOG4105C1P efflux transporter, rnd family, mfp subunit AL504_05930 ENOG4105RJZ Transcriptional regulator AL504_05935 ENOG4105CPC Aldo Keto reductase AL504_05950 ENOG4105PF9 Transcriptional regulator AL504_05965 ENOG4105EWC Purine nucleoside phosphorylase AL504_05980 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL504_05985 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL504_05995 ENOG4105VDB UPF0125 protein AL504_06000 ENOG4108Z1B Cyclase dehydrase AL504_06005 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AL504_06010 ENOG4105BZU Histidine kinase AL504_06025 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AL504_06030 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AL504_06035 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AL504_06040 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AL504_06075 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AL504_06080 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL504_06090 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AL504_06095 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL504_06100 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) AL504_06105 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AL504_06110 ENOG4105DZP Membrane-associated zinc metalloprotease AL504_06115 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AL504_06120 ENOG4105KNE Phosphatidate cytidylyltransferase AL504_06125 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AL504_06130 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AL504_06135 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AL504_06140 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AL504_06145 ENOG4105CE9 30S ribosomal protein S2 AL504_06150 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AL504_06155 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AL504_06165 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) AL504_06170 ENOG4108VKG metal-dependent hydrolase AL504_06175 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AL504_06190 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AL504_06205 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AL504_06225 ENOG4105DTS flagellar hook-associated AL504_06230 ENOG4105MQ3 flagellar protein FliS AL504_06245 ENOG4105D00 flagellar biosynthetic protein flhB AL504_06255 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AL504_06260 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AL504_06265 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL504_06275 ENOG4108JIR Flagellum-specific ATP synthase AL504_06290 ENOG4107ZI8 flagellar basal body-associated protein flil AL504_06295 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AL504_06310 ENOG4105CN7 Flagellar biosynthetic protein FliP AL504_06315 ENOG4105VS8 Flagellar biosynthetic protein fliq AL504_06320 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AL504_06325 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AL504_06330 ENOG4105C8Q Methyl-accepting chemotaxis AL504_06340 ENOG4105C8Q Methyl-accepting chemotaxis AL504_06345 ENOG4105C8Q Methyl-accepting chemotaxis AL504_06350 ENOG4105DTJ flagellar hook-associated protein AL504_06355 ENOG4105E1Q flagellar hook-associated protein AL504_06360 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AL504_06365 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL504_06370 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AL504_06375 ENOG4105CGA flagellar basal-body rod protein FlgG AL504_06380 ENOG4108KPB Flagellar basal-body rod protein FlgF AL504_06385 ENOG4105BZE flagellar hook protein, FlgE AL504_06390 ENOG4105W00 Flagellar hook capping protein AL504_06395 ENOG4108ZC9 flagellar basal-body rod protein flgc AL504_06400 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AL504_06410 ENOG4105M9M anti-sigma28 factor FlgM AL504_06420 ENOG4105FZW flagellar biosynthesis regulator FlhF AL504_06420 ENOG4105FZW flagellar biosynthesis regulator FlhF AL504_06425 ENOG4105D7B Flagellar biosynthesis protein flha AL504_06430 ENOG4105D00 flagellar biosynthetic protein flhB AL504_06435 ENOG4105C8Q Methyl-accepting chemotaxis AL504_06440 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) AL504_06445 ENOG4108VYJ response regulator receiver protein AL504_06450 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AL504_06455 ENOG4105BZU Histidine kinase AL504_06460 ENOG4105C8Q Methyl-accepting chemotaxis AL504_06465 ENOG4108V3W Chemotaxis protein, CheW AL504_06480 ENOG4105ER2 Ompa motb domain protein AL504_06485 ENOG4107RD7 Flagellar Motor Protein, MotA AL504_06490 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region AL504_06495 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) AL504_06500 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL504_06505 ENOG4106R49 Methyltransferase AL504_06510 ENOG4105I03 Flagellin AL504_06520 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AL504_06525 ENOG4105FAW cDP-glucose 4,6-dehydratase AL504_06540 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AL504_06550 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AL504_06580 ENOG4105CBN LysR family transcriptional regulator AL504_06585 ENOG4105CHR reductase AL504_06590 ENOG4107QN2 dihydrolipoyl dehydrogenase AL504_06595 ENOG4107QSN dihydrolipoamide acetyltransferase AL504_06600 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AL504_06605 ENOG4105BZU Histidine kinase AL504_06610 ENOG4108ZXC Two component transcriptional regulator, luxr family AL504_06620 ENOG4105DGW oligopeptidase A AL504_06640 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AL504_06645 ENOG4105BZS acriflavin resistance protein AL504_06650 ENOG4105C1P efflux transporter, rnd family, mfp subunit AL504_06655 ENOG4105CR8 Transcriptional regulator AL504_06660 ENOG4105FE9 pseudouridine synthase AL504_06665 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) AL504_06670 ENOG4105C57 major facilitator superfamily AL504_06685 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AL504_06690 ENOG4108WUH Transcriptional regulator, TetR family AL504_06695 ENOG4108VWS Yaeq family AL504_06700 ENOG4108JQ6 ABC transporter AL504_06705 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL504_06710 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL504_06715 ENOG4105DEF Extracellular solute-binding protein, family 5 AL504_06720 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL504_06725 ENOG4105DUM transcriptional regulator, lysR family AL504_06730 ENOG4105HSS phospholipase C AL504_06750 ENOG4108VAU general secretion pathway protein G AL504_06755 ENOG41069X0 general secretion pathway protein h AL504_06760 ENOG4105X5Z General secretion pathway protein I AL504_06765 ENOG4108WWZ General secretion pathway protein J AL504_06770 ENOG4108RTD type II secretion system protein K AL504_06800 ENOG4107QHF type ii secretion system protein e AL504_06805 ENOG4105GVR general secretion pathway protein D AL504_06810 ENOG4105D7Q type ii secretion system AL504_06815 ENOG4108YZA Nitrogen regulatory protein pii AL504_06825 ENOG4105CUY Mechanosensitive ion channel AL504_06830 ENOG4105CH7 arginosuccinase AL504_06840 ENOG4107QN2 dihydrolipoyl dehydrogenase AL504_06845 ENOG4107QSN dihydrolipoamide acetyltransferase AL504_06850 ENOG4105CPP Dehydrogenase, E1 component AL504_06855 ENOG4107R0V Pyruvate dehydrogenase AL504_06860 ENOG4105E0K tonB-dependent siderophore receptor AL504_06885 ENOG4105W1Y Transcriptional regulator AL504_06905 ENOG4105CSP Major Facilitator Superfamily AL504_06915 ENOG4108R6K riboflavin synthase, subunit alpha AL504_06925 ENOG41073TP transcriptional regulator AL504_06930 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AL504_06975 ENOG4105EA8 2-Nitropropane dioxygenase AL504_07025 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AL504_07030 ENOG4108SC4 )-transporter AL504_07035 ENOG4105ETE Transcriptional regulator (LacI family AL504_07040 ENOG4108I0C methyltransferase AL504_07050 ENOG4108JQ7 (ABC) transporter AL504_07055 ENOG4105C3U ABC transporter AL504_07070 ENOG4105DDR sarcosine oxidase (Beta subunit) AL504_07095 ENOG4105DEF Extracellular solute-binding protein, family 5 AL504_07100 ENOG4108IG5 Transcriptional regulator AL504_07105 ENOG4107RTG Major Facilitator superfamily AL504_07120 ENOG4105JQN Transcriptional regulator AL504_07130 ENOG4105F04 LysR family Transcriptional regulator AL504_07155 ENOG4105ETT transcriptional Regulator, LysR family AL504_07160 ENOG4105BZ1 (ABC) transporter AL504_07205 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AL504_07210 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL504_07215 ENOG4108JJ7 ABC transporter AL504_07225 ENOG4105EW9 transcriptional regulator AsnC family AL504_07260 ENOG4105CEY Amp-dependent synthetase and ligase AL504_07265 ENOG4105FDP GntR family transcriptional regulator AL504_07280 ENOG4105CSH Transporter AL504_07285 ENOG4108S8N class II Aldolase AL504_07295 ENOG4105E09 nadh pyrophosphatase AL504_07310 ENOG4105CNM Receptor AL504_07315 ENOG4105CY2 Citrate transporter AL504_07320 ENOG4105CBN LysR family transcriptional regulator AL504_07330 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AL504_07335 ENOG4107S01 Repressor protein MetJ AL504_07380 ENOG4105E39 Enoyl-CoA hydratase AL504_07385 ENOG4105BZU Histidine kinase AL504_07395 ENOG4105C01 Dihydroxy-acid dehydratase AL504_07405 ENOG4107RSM transcriptional regulator AL504_07410 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL504_07430 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AL504_07445 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AL504_07450 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AL504_07455 ENOG41060IM Heme exporter protein AL504_07465 ENOG4105DA4 cytochrome c-type biogenesis protein AL504_07470 ENOG4105KWW Biogenesis protein AL504_07480 ENOG4105DB1 molybdopterin oxidoreductase AL504_07485 ENOG4106WHD Tetrathionate reductase AL504_07490 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AL504_07495 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AL504_07500 ENOG4108J2R molybdopterin oxidoreductase AL504_07510 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AL504_07515 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AL504_07520 ENOG41060IM Heme exporter protein AL504_07530 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) AL504_07535 ENOG4105DA4 cytochrome c-type biogenesis protein AL504_07540 ENOG4107QX9 Thiol disulfide interChange protein AL504_07545 ENOG4105KWW Biogenesis protein AL504_07560 ENOG4105EUB pirin domain protein AL504_07565 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AL504_07570 ENOG4105CR8 Transcriptional regulator AL504_07575 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AL504_07585 ENOG4105C1P efflux transporter, rnd family, mfp subunit AL504_07595 ENOG4106PGW Short-chain dehydrogenase reductase Sdr AL504_07615 ENOG4108K3Z AraC family transcriptional regulator AL504_07650 ENOG4105CHR reductase AL504_07665 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) AL504_07670 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL504_07680 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AL504_07685 ENOG4108IPT Naphthoate synthase AL504_07690 ENOG4107QI1 Mate efflux family protein AL504_07710 ENOG4108Q5Y Membrane AL504_07725 ENOG4105N14 lysine exporter protein LysE YggA AL504_07735 ENOG4105DC8 reductase AL504_07745 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AL504_07750 ENOG4105MPD Cytochrome AL504_07760 ENOG4108W3Y Transcriptional regulator, Crp Fnr family AL504_07770 ENOG4105E6M Sulphatase-modifying factor protein AL504_07775 ENOG4105DSQ Nitric oxide reductase AL504_07795 ENOG4105CEY Amp-dependent synthetase and ligase AL504_07800 ENOG4105CSU acyl-Coa dehydrogenase AL504_07815 ENOG4108IY8 ABC, transporter AL504_07845 ENOG4105EXG Transcriptional regulator AL504_07880 ENOG41062BK proline dehydrogenase AL504_07885 ENOG4105SX7 Transporter AL504_07890 ENOG4105MWK D-amino acid dehydrogenase, small subunit AL504_07895 ENOG4105KPV Transcriptional regulator AL504_07900 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AL504_07920 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AL504_07935 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AL504_07975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL504_07985 ENOG4105C2D reductase AL504_07990 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL504_08000 ENOG4105KTH gatB Yqey AL504_08010 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AL504_08030 ENOG4105BZU Histidine kinase AL504_08035 ENOG4108TUY outer membrane protein PgaA AL504_08040 ENOG4107BJW polysaccharide deacetylase AL504_08045 ENOG4105CND Glycosyl transferase, family 2 AL504_08055 ENOG4105EU0 Major facilitator Superfamily AL504_08060 ENOG4105ID8 Transcriptional regulator, ARAC family AL504_08065 ENOG4108JQC penicillin-binding protein 1A AL504_08070 ENOG4108R1E Serine threonine protein phosphatase 1 AL504_08085 ENOG4105CV8 reductase AL504_08090 ENOG4108JJ7 ABC transporter AL504_08100 ENOG4105DHU Bile acid AL504_08105 ENOG4105C5Q Transcriptional regulator AL504_08120 ENOG4105E2Y ABC, transporter AL504_08180 ENOG4108YXU transcriptional regulator AsnC family AL504_08220 ENOG4108R6G acetyltransferase AL504_08250 ENOG4105P8F nudix hydrolase AL504_08255 ENOG4105C0R drug resistance transporter emrb qaca subfamily AL504_08280 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AL504_08285 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AL504_08290 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AL504_08295 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AL504_08300 ENOG4105VJV 50s ribosomal protein L35 AL504_08305 ENOG4105C0P Mg chelatase subunit ChlI AL504_08310 ENOG4105W0Z cytoplasmic protein AL504_08320 ENOG4108YZA Nitrogen regulatory protein pii AL504_08325 ENOG4105BZU Histidine kinase AL504_08330 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AL504_08335 ENOG41080Z8 PHOSPHOCARRIER protein AL504_08345 ENOG4105D7Z glutathione synthase AL504_08350 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AL504_08355 ENOG4105C22 threonyL-tRNA synthetase AL504_08360 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AL504_08365 ENOG41068CG regulatoR AL504_08370 ENOG4105D4P Coproporphyrinogen iii oxidase AL504_08375 ENOG4107TXC Transcriptional regulator AL504_08400 ENOG4105CE7 Amidase, hydantoinase carbamoylase family AL504_08405 ENOG4105C26 Dehydrogenase AL504_08415 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL504_08420 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL504_08430 ENOG4105K8K Cupin 2, conserved barrel AL504_08440 ENOG4105FR1 rard protein AL504_08445 ENOG4105DIQ Transcriptional regulator AL504_08450 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter AL504_08455 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL504_08460 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AL504_08465 ENOG4105C01 Dihydroxy-acid dehydratase AL504_08510 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AL504_08515 ENOG4105CH5 extracellular solute-binding protein, family 7 AL504_08520 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AL504_08535 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AL504_08540 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AL504_08545 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AL504_08550 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AL504_08555 ENOG4105ERG peptidase m48, ste24p AL504_08560 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AL504_08565 ENOG4105BZU Histidine kinase AL504_08570 ENOG4105BZU Histidine kinase AL504_08585 ENOG4105CNG UPF0061 protein AL504_08595 ENOG4107S2Z UPF0761 membrane protein AL504_08605 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AL504_08830 ENOG4108C66 Inherit from COG: DNA primase AL504_08940 ENOG4108NF7 phage-type endonuclease AL504_08945 ENOG4108PNI recT protein AL504_08955 ENOG4105FA0 parb-like partition protein AL504_08970 ENOG4105EXC Acyl-transferase AL504_08985 ENOG4105CPK Glycosyl transferase (Group 1 AL504_09000 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL504_09010 ENOG4105VCC 30S ribosomal protein S21 AL504_09015 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AL504_09020 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AL504_09025 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) AL504_09030 ENOG4105EPW hflc protein AL504_09035 ENOG4107QJR hflk protein AL504_09040 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AL504_09045 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AL504_09050 ENOG4105CIH Imidazole acetol-phosphate transaminase AL504_09055 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AL504_09060 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL504_09065 ENOG4105N21 Membrane AL504_09070 ENOG4105CUT histidyl-tRNA synthetase AL504_09075 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AL504_09085 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AL504_09090 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AL504_09095 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AL504_09100 ENOG4105CJP fad dependent oxidoreductase AL504_09105 ENOG4105CDA abc transporter atp-binding protein AL504_09110 ENOG4105E5Q amino acid AbC transporter AL504_09115 ENOG4106TNF Periplasmic binding protein AL504_09120 ENOG4105WBV Transcriptional regulator AL504_09125 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AL504_09130 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AL504_09135 ENOG4105K5M 30s ribosomal protein S16 AL504_09145 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AL504_09150 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AL504_09165 ENOG4105MWK D-amino acid dehydrogenase, small subunit AL504_09175 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AL504_09180 ENOG4105KPY Small multidrug resistance protein AL504_09185 ENOG4105QVC MOSC domain-containing protein AL504_09190 ENOG4105EV8 ectoine hydroxylase AL504_09195 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) AL504_09200 ENOG4108JPW Aminotransferase AL504_09220 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AL504_09230 ENOG4107Z3H Transcriptional regulator, TetR family AL504_09235 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL504_09245 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL504_09250 ENOG4105K63 Thioredoxin AL504_09255 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AL504_09270 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AL504_09275 ENOG4105WPN DNA integration recombination invertion protein AL504_09320 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AL504_09335 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes AL504_09345 ENOG4105CW7 secretion protein, HlyD family AL504_09350 ENOG4105C0R drug resistance transporter emrb qaca subfamily AL504_09360 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AL504_09365 ENOG4105D7A ATP-binding protein AL504_09370 ENOG4105CDY transcriptional regulatory protein AL504_09375 ENOG4105C12 Phosphoribosylglycinamide synthetase AL504_09380 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AL504_09385 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AL504_09390 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AL504_09395 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AL504_09400 ENOG4108Z03 MAF-like protein AL504_09405 ENOG4105CK2 sodium dicarboxylate symporter AL504_09415 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL504_09445 ENOG4105C03 ribonuclease AL504_09700 ENOG4108PNI recT protein AL504_09765 ENOG4106JH6 (LipO)protein AL504_09775 ENOG4105BZU Histidine kinase AL504_09785 ENOG4105CKD glutathione-regulated potassium-efflux system protein AL504_09790 ENOG4105BZ1 (ABC) transporter AL504_09805 ENOG4105KRS Proteinase inhibitor AL504_09815 ENOG4107BJW polysaccharide deacetylase AL504_09825 ENOG4106WTF Glycosyl transferase, family 2 AL504_09830 ENOG4107BJW polysaccharide deacetylase AL504_09835 ENOG4105CPK Glycosyl transferase (Group 1 AL504_09840 ENOG4105C0B DNA polymerase III (alpha subunit) AL504_09855 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AL504_09860 ENOG4105CQ7 ATP-dependent helicase AL504_09865 ENOG4108EKC n-acetylglutamate synthase AL504_09870 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) AL504_09875 ENOG4105HSS phospholipase C AL504_09880 ENOG4108UTW Plays a role in the regulation of phosphate uptake AL504_09890 ENOG4105CSU acyl-Coa dehydrogenase AL504_09900 ENOG4107QSV RmuC domain protein AL504_09920 ENOG4105D38 putrescine abc transporter AL504_09925 ENOG4105F38 ABC transporter, permease AL504_09930 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL504_09940 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) AL504_09950 ENOG4105CV6 ABC transporter, permease AL504_09955 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AL504_09965 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL504_09975 ENOG4105C8Y Acetylornithine aminotransferase AL504_09980 ENOG4105DBV ornithine carbamoyltransferase AL504_09985 ENOG4108XEP Alpha Beta Hydrolase Fold protein AL504_10005 ENOG4105GAK amidohydrolase 2 AL504_10010 ENOG4105C5Q Transcriptional regulator AL504_10015 ENOG4105GR3 Histidine kinase AL504_10025 ENOG4105BZS acriflavin resistance protein AL504_10030 ENOG4105ENT Efflux transporter rnd family, mfp subunit AL504_10035 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AL504_10040 ENOG4105CDH Citrulline--aspartate ligase AL504_10045 ENOG4105DFH Transport of potassium into the cell (By similarity) AL504_10050 ENOG4105DHQ Histidine kinase AL504_10055 ENOG4105XJC Two component transcriptional regulator (Winged helix family AL504_10080 ENOG4105K70 DNA-binding protein AL504_10085 ENOG4107E2E PKHD-type hydroxylase AL504_10090 ENOG4105C28 cystathionine AL504_10095 ENOG4105C2N RNA methyltransferase TrmH family group 3 AL504_10100 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AL504_10120 ENOG41082BV acetyltransferase AL504_10130 ENOG4105RK9 auxin efflux carrier AL504_10135 ENOG41066VF YeeE YedE family protein AL504_10140 ENOG4105CBC glutamate synthase AL504_10145 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AL504_10155 ENOG41067HS methyltransferase AL504_10200 ENOG4105RPH Inner membrane protein YddG AL504_10210 ENOG4105BZU Histidine kinase AL504_10320 ENOG4108MAJ Membrane AL504_10330 ENOG4108REF Sporulation integral membrane protein ytvi AL504_10360 ENOG4105T86 cytochrome C AL504_10365 ENOG4107QTF adenylosuccinate lyase AL504_10370 ENOG4108U78 Glutathione S-transferase AL504_10375 ENOG4105HF0 Membrane AL504_10380 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AL504_10385 ENOG4105ETT transcriptional Regulator, LysR family AL504_10400 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AL504_10405 ENOG4105W8H transhydrogenase (subunit alpha AL504_10410 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AL504_10415 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AL504_10420 ENOG4105EU8 FAD linked oxidase domain protein AL504_10425 ENOG4105CQB FAD linked oxidase domain protein AL504_10430 ENOG4105CQB FAD linked oxidase domain protein AL504_10435 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AL504_10440 ENOG4105D1U peptidase U62 modulator of DNA gyrase AL504_10445 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS AL504_10455 ENOG4105CD8 aminopeptidase N AL504_10460 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AL504_10475 ENOG4105D6E homoserine dehydrogenase AL504_10480 ENOG4105CHM Aminotransferase AL504_10490 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AL504_10500 ENOG4108IAB Phoh family AL504_10520 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_10525 ENOG4108IV0 ABC, transporter AL504_10530 ENOG4105C0Z ABC transporter AL504_10535 ENOG4105CHR reductase AL504_10560 ENOG4105F0N pyrophosphate phospho-hydrolase AL504_10580 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AL504_10585 ENOG4108ZCF integral membrane protein AL504_10590 ENOG4108ZCF integral membrane protein AL504_10595 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AL504_10600 ENOG4105CMV Succinyl-CoA synthetase subunit beta AL504_10610 ENOG4105CEY Amp-dependent synthetase and ligase AL504_10615 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AL504_10620 ENOG4105DZ2 Transcriptional regulator AL504_10625 ENOG4108004 Modulates RecA activity (By similarity) AL504_10630 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AL504_10640 ENOG4105DHQ Histidine kinase AL504_10645 ENOG4105CSH Transporter AL504_10665 ENOG4105CXT aspartate transcarbamylase AL504_10725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL504_10750 ENOG4105EW9 transcriptional regulator AsnC family AL504_10760 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AL504_10765 ENOG4105DHU Bile acid AL504_10770 ENOG4105CDU Replicative dna helicase AL504_10780 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AL504_10785 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AL504_10795 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AL504_10800 ENOG4105NX3 Membrane AL504_10805 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) AL504_10810 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AL504_10815 ENOG4105CTB Polyprenyl synthetase AL504_10820 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AL504_10855 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AL504_10865 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL504_10870 ENOG4105DUM transcriptional regulator, lysR family AL504_10880 ENOG4105KHC sulfurtransferase AL504_10890 ENOG4105D0M Protease HtpX homolog AL504_10895 ENOG4105EJQ L-serine dehydratase AL504_10900 ENOG4105EAM Na Pi-cotransporter AL504_10905 ENOG4108KQ5 Integrase catalytic subunit AL504_10915 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) AL504_10925 ENOG4105C2M dna polymerase I AL504_10930 ENOG4108URH decarboxylase AL504_10935 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B AL504_10965 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AL504_10970 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AL504_10975 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AL504_10980 ENOG4105CHV Transcription elongation factor NusA AL504_10985 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AL504_10990 ENOG4105FE9 pseudouridine synthase AL504_10995 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AL504_11005 ENOG4105EJC lysr family transcriptional regulator AL504_11010 ENOG4105CKI cobalamin synthesis protein AL504_11015 ENOG4105CKI cobalamin synthesis protein AL504_11030 ENOG4105XJC Two component transcriptional regulator (Winged helix family AL504_11035 ENOG4105DHQ Histidine kinase AL504_11040 ENOG4105C0H protease AL504_11045 ENOG4108RXX maleylacetoacetate isomerase AL504_11060 ENOG4105W5Q DNA repair protein (RadC AL504_11065 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AL504_11070 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AL504_11075 ENOG4105NRA 50s ribosomal protein l31 type b AL504_11085 ENOG4107QI1 Mate efflux family protein AL504_11095 ENOG4108ZJI phenylacetic acid degradation protein AL504_11100 ENOG4108UKI Enoyl-CoA hydratase AL504_11105 ENOG4105C26 Dehydrogenase AL504_11110 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AL504_11115 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit AL504_11120 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit AL504_11125 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit AL504_11130 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit AL504_11135 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein AL504_11145 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AL504_11150 ENOG4105D0M Protease HtpX homolog AL504_11155 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AL504_11160 ENOG4105P8F nudix hydrolase AL504_11165 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AL504_11205 ENOG4105ECW sulfate abc transporter AL504_11210 ENOG4108I5D sulfate abc transporter AL504_11215 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AL504_11220 ENOG4105D3R alkyl hydroperoxide reductase AL504_11225 ENOG4105CSU acyl-Coa dehydrogenase AL504_11245 ENOG4105C10 Electron transfer flavoprotein AL504_11250 ENOG4105BZJ Electron transfer flavoprotein AL504_11260 ENOG4105CVE Lytic murein transglycosylase AL504_11280 ENOG4105C6T cysteine synthase AL504_11290 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) AL504_11295 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AL504_11300 ENOG4105CFV Tetratricopeptide repeat protein AL504_11315 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AL504_11320 ENOG4105CAT Cytidine monophosphate kinase AL504_11325 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AL504_11335 ENOG4105CIH Imidazole acetol-phosphate transaminase AL504_11340 ENOG4105CQC Prephenate dehydratase AL504_11345 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AL504_11350 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL504_11355 ENOG4105UYK outer membrane protein a AL504_11360 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AL504_11365 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AL504_11370 ENOG4105F27 Major Facilitator AL504_11395 ENOG4105CVE Lytic murein transglycosylase AL504_11410 ENOG4105BZ1 (ABC) transporter AL504_11425 ENOG4105VDW Csbd family AL504_11430 ENOG4105K3G Periplasmic Protein AL504_11435 ENOG4105JAB phenazine biosynthesis protein, phzf family AL504_11450 ENOG4105D5K Hemolysin activator protein AL504_11475 ENOG4108NVM synthesis repressor PhaR AL504_11480 ENOG4105CHR reductase AL504_11485 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class AL504_11490 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AL504_11495 ENOG4105C34 Pseudouridine synthase AL504_11500 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AL504_11505 ENOG4105DVT helicase AL504_11510 ENOG4105BZM domain protein AL504_11520 ENOG4105C31 Tryptophanyl-tRNA synthetase AL504_11545 ENOG4105E0K tonB-dependent siderophore receptor AL504_11550 ENOG4108S3W Anti-feci sigma factor, fecr AL504_11555 ENOG4108SF5 RNA Polymerase AL504_11560 ENOG4105D6Z AFG1 family ATPase AL504_11565 ENOG4107QN2 dihydrolipoyl dehydrogenase AL504_11570 ENOG4105C7S Dehydrogenase AL504_11575 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AL504_11580 ENOG4108XM1 transcriptional regulator AsnC family AL504_11585 ENOG4105K6H D-cysteine desulfhydrase AL504_11600 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AL504_11605 ENOG4105EPD Oligopeptide transporter, Opt family AL504_11610 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AL504_11615 ENOG4105C6K Malic enzyme AL504_11630 ENOG4105BZN citrate synthase AL504_11635 ENOG41060IS Flavinator of succinate dehydrogenase AL504_11640 ENOG4105E33 succinate dehydrogenase AL504_11650 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AL504_11655 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AL504_11660 ENOG4105FDP GntR family transcriptional regulator AL504_11665 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AL504_11670 ENOG4105CR4 methylisocitrate lyase AL504_11675 ENOG4105BZN citrate synthase AL504_11680 ENOG4105DXD 2-methylcitrate dehydratase AL504_11685 ENOG4108YXA Membrane AL504_11720 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL504_11730 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AL504_11740 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AL504_11750 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AL504_11785 ENOG4105DEF Extracellular solute-binding protein, family 5 AL504_11790 ENOG4108JQ6 ABC transporter AL504_11795 ENOG4105D44 asparaginase AL504_11805 ENOG4107YB6 acetyltransferase, (GNAT) family AL504_11825 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AL504_11830 ENOG4108535 NAD dependent epimerase/dehydratase family AL504_11850 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AL504_11855 ENOG4105C5W Aldolase AL504_11860 ENOG4108Q5Y Membrane AL504_11865 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL504_11875 ENOG4108ZJF Glcg protein AL504_11880 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AL504_11885 ENOG4105K4H Nlp p60 protein AL504_11895 ENOG4107R11 Transcriptional regulator AL504_11900 ENOG4105C26 Dehydrogenase AL504_11910 ENOG4108MP6 LysR family Transcriptional regulator AL504_11920 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AL504_11935 ENOG4108XRP Membrane AL504_11970 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) AL504_11975 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AL504_11980 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AL504_11985 ENOG4105C3F Signal peptidase i AL504_11990 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AL504_11995 ENOG4105C0H protease AL504_12010 ENOG4105EMN RNA polymerase sigma factor AL504_12020 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AL504_12025 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AL504_12030 ENOG4105CHR reductase AL504_12035 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AL504_12040 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL504_12045 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AL504_12050 ENOG4105VGS 50s ribosomal protein l32 AL504_12060 ENOG4108UHJ MAF-like protein AL504_12065 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AL504_12070 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AL504_12075 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) AL504_12080 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AL504_12085 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AL504_12090 ENOG4105EI2 Pseudouridine synthase AL504_12095 ENOG4107QQB Ribonuclease E AL504_12110 ENOG41061N2 exported protein AL504_12115 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AL504_12120 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AL504_12125 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AL504_12130 ENOG4105CWC Acetylornithine deacetylase AL504_12135 ENOG4105CSH Transporter AL504_12140 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AL504_12145 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) AL504_12155 ENOG4105M4H endoribonuclease L-psp AL504_12160 ENOG4107RH7 Nicotinate phosphoribosyltransferase AL504_12165 ENOG4108Z4U Ferredoxin AL504_12170 ENOG4105DP0 ferredoxin-NADP reductase AL504_12180 ENOG4108R3D Electron transport complex AL504_12185 ENOG4105CSM endonuclease III AL504_12190 ENOG4105C0Z ABC transporter AL504_12195 ENOG4108IV0 ABC, transporter AL504_12205 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_12220 ENOG4105CM2 brancheD-chain amino acid aminotransferase AL504_12225 ENOG4105HSS phospholipase C AL504_12235 ENOG4108IV0 ABC, transporter AL504_12240 ENOG4105C0Z ABC transporter AL504_12265 ENOG4107QCX Transporter AL504_12270 ENOG4108JJB ABC transporter AL504_12275 ENOG4105E0X reductase AL504_12280 ENOG4107835 probably involved in intracellular septation (By similarity) AL504_12290 ENOG4107TF3 peptidylprolyl cis-trans isomerase AL504_12295 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AL504_12305 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AL504_12310 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) AL504_12315 ENOG4108UN4 phage SPO1 DNA polymerase-related protein AL504_12320 ENOG41072GX Peptidase M22 Glycoprotease AL504_12325 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AL504_12330 ENOG4105E0F Histidine kinase AL504_12335 ENOG4105D3R alkyl hydroperoxide reductase AL504_12340 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AL504_12350 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AL504_12355 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AL504_12360 ENOG4108JA2 transcriptioN-repair coupling factor AL504_12365 ENOG4105EAC phosphoserine phosphatase AL504_12370 ENOG4105IB0 filamentous hemagglutinin family outer membrane protein AL504_12380 ENOG4108ESX Receptor AL504_12390 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AL504_12395 ENOG4105C8S subunit m AL504_12405 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AL504_12410 ENOG4105DF2 NADH dehydrogenase subunit j AL504_12415 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AL504_12420 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AL504_12425 ENOG4108IEH NADH dehydrogenase subunit g AL504_12440 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AL504_12445 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AL504_12450 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AL504_12455 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AL504_12460 ENOG4108Z9W Outer membrane porin AL504_12485 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AL504_12490 ENOG4105CBD Diacylglycerol kinase AL504_12510 ENOG4108IG5 Transcriptional regulator AL504_12515 ENOG4105C1P efflux transporter, rnd family, mfp subunit AL504_12520 ENOG4105BZS acriflavin resistance protein AL504_12525 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AL504_12540 ENOG4105BZS acriflavin resistance protein AL504_12545 ENOG4105ENT Efflux transporter rnd family, mfp subunit AL504_12550 ENOG4105C94 Transporter AL504_12565 ENOG4105BZS acriflavin resistance protein AL504_12580 ENOG4105JN3 extra-cytoplasmic solute receptor family protein AL504_12605 ENOG4106R87 Extracellular solute-binding protein, family 5 AL504_12640 ENOG4105CKW Inner membrane protein yedI AL504_12650 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AL504_12670 ENOG4108SF5 RNA Polymerase AL504_12695 ENOG4105CHR reductase AL504_12700 ENOG4105D4T Citrate transporter AL504_12710 ENOG4105ECM Sensor protein basS pmrB AL504_12720 ENOG4108ZXC Two component transcriptional regulator, luxr family AL504_12725 ENOG4105BZU Histidine kinase AL504_12735 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AL504_12755 ENOG4105CHH sulfate transporter AL504_12765 ENOG4108S3W Anti-feci sigma factor, fecr AL504_12770 ENOG4108SF5 RNA Polymerase AL504_12775 ENOG4105CNM Receptor AL504_12800 ENOG4108NFJ ABC transporter AL504_12835 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AL504_12845 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AL504_12885 ENOG4105C8Q Methyl-accepting chemotaxis AL504_12915 ENOG4105CP7 Triose-phosphate isomerase AL504_12920 ENOG4108JA1 polyketide synthase AL504_12940 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AL504_12950 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AL504_12965 ENOG41064T2 transcriptional regulator, lysR family AL504_12970 ENOG4105ES4 Nitrilase AL504_12975 ENOG4105NIV Esterase AL504_12990 ENOG4105C7B Threonine dehydratase AL504_13000 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AL504_13005 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AL504_13015 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AL504_13020 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AL504_13025 ENOG4108ZP8 Acetolactate synthase small subunit AL504_13030 ENOG4105C7K acetolactate synthase AL504_13040 ENOG4105D1Q UPF0246 protein AL504_13045 ENOG4105DTD Dehydrogenase AL504_13065 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AL504_13070 ENOG4105DIA mandelate racemase muconate lactonizing AL504_13100 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AL504_13105 ENOG4105D1H recombination factor protein RarA AL504_13110 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AL504_13145 ENOG4105C2X Arabinose 5-phosphate isomerase AL504_13155 ENOG4105KME endoribonuclease L-psp AL504_13160 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AL504_13165 ENOG4105CNU cell division protein FtsK AL504_13170 ENOG4105C3M thioredoxin reductase AL504_13175 ENOG4105C98 muts2 protein AL504_13185 ENOG4107QN1 sodium solute AL504_13205 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AL504_13210 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) AL504_13215 ENOG4105C08 Histidine kinase AL504_13220 ENOG4105EEX Two component transcriptional regulator (Winged helix family AL504_13235 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AL504_13240 ENOG4105C8Q Methyl-accepting chemotaxis AL504_13275 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AL504_13295 ENOG4108YYQ gCN5-related N-acetyltransferase AL504_13310 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AL504_13315 ENOG4105CFG Acts as a chaperone (By similarity) AL504_13325 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AL504_13335 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AL504_13340 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AL504_13345 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AL504_13350 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AL504_13355 ENOG41090R7 Ferric uptake AL504_13360 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AL504_13365 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AL504_13370 ENOG4105D4A Cell wall formation (By similarity) AL504_13440 ENOG4105CC0 LysR family Transcriptional regulator AL504_13450 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AL504_13455 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate AL504_13460 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AL504_13475 ENOG41069M3 Transcriptional regulator AL504_13480 ENOG4107TH8 cina domain protein AL504_13495 ENOG4105C1J atp-dependent rna helicase AL504_13505 ENOG4107ZSV Receptor AL504_13510 ENOG4105EYM Major Facilitator superfamily AL504_13530 ENOG4105CM2 brancheD-chain amino acid aminotransferase AL504_13550 ENOG4105ERG peptidase m48, ste24p AL504_13565 ENOG4108Z9W Outer membrane porin AL504_13570 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AL504_13585 ENOG4107RAQ aminopeptidase AL504_13595 ENOG4105D0A hydroxylase AL504_13600 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AL504_13620 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AL504_13625 ENOG4105ECP epimerase AL504_13635 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AL504_13645 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AL504_13655 ENOG4105C9U ATP-dependent DNA helicase RecQ AL504_13670 ENOG4105CX6 glutaminyL-tRNA synthetase AL504_13680 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AL504_13685 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AL504_13690 ENOG4107258 Transcriptional regulator AL504_13700 ENOG4107QMS site-determining protein AL504_13705 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) AL504_13720 ENOG4105C5H ABC transporter AL504_13725 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AL504_13745 ENOG4108JQ7 (ABC) transporter AL504_13750 ENOG4105C3U ABC transporter AL504_13755 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL504_13760 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL504_13765 ENOG4105DEF Extracellular solute-binding protein, family 5 AL504_13790 ENOG4105FUY alpha subunit AL504_13800 ENOG4105J5T Amp-dependent synthetase and ligase AL504_13815 ENOG4106IPI cyclase, family AL504_13820 ENOG4105CHR reductase AL504_13835 ENOG4105C0Z ABC transporter AL504_13840 ENOG4108IV0 ABC, transporter AL504_13845 ENOG4105K64 Glycosyl transferase, family 2 AL504_13865 ENOG4108UHU Aldolase AL504_13875 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AL504_13890 ENOG4108SF5 RNA Polymerase AL504_13895 ENOG4108S3W Anti-feci sigma factor, fecr AL504_13900 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AL504_13925 ENOG4105CUZ uba thif-type nad fad binding protein AL504_13930 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AL504_13935 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AL504_13940 ENOG4105DJY efflux transporter, rnd family, mfp subunit AL504_13955 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AL504_13965 ENOG4105D5U fad dependent oxidoreductase AL504_13975 ENOG4105CR8 Transcriptional regulator AL504_14005 ENOG4105ERH Fumarylacetoacetate hydrolase AL504_14010 ENOG4107RSM transcriptional regulator AL504_14015 ENOG4105CSU acyl-Coa dehydrogenase AL504_14025 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AL504_14030 ENOG4105CUB amino acid AL504_14035 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL504_14040 ENOG4105DUM transcriptional regulator, lysR family AL504_14055 ENOG4105C9Q fumarate hydratase class II AL504_14060 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AL504_14070 ENOG4105DQR SNARE associated Golgi AL504_14080 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AL504_14090 ENOG4105CXB phosphoribosylaminoimidazole synthetase AL504_14095 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) AL504_14105 ENOG4105DJ0 Poly(A) Polymerase AL504_14110 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AL504_14115 ENOG4108MGF sugar kinase AL504_14120 ENOG4105CI0 Citrate lyase AL504_14130 ENOG4108M9J MaoC like domain protein AL504_14140 ENOG4108UKI Enoyl-CoA hydratase AL504_14145 ENOG4105C1G acyl-Coa dehydrogenase AL504_14150 ENOG4105CC9 acyl-Coa dehydrogenase AL504_14165 ENOG4105CEY Amp-dependent synthetase and ligase AL504_14175 ENOG4105EA8 2-Nitropropane dioxygenase AL504_14190 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr AL504_14195 ENOG410900P UPF0336 protein AL504_14200 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AL504_14205 ENOG4107SDU Methyl-accepting chemotaxis AL504_14225 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AL504_14230 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AL504_14235 ENOG4105E9Q Acyl-transferase AL504_14255 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AL504_14260 ENOG4107QPN acyl-Coa dehydrogenase AL504_14270 ENOG4105CA9 Pyruvate kinase AL504_14275 ENOG4105BZW Glycerate kinase AL504_14280 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AL504_14285 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AL504_14295 ENOG4105EHM Aminoglycoside phosphotransferase AL504_14300 ENOG4108S0S Nucleotidyl transferase AL504_14325 ENOG4105KZX Pterin carbinolamine dehydratase AL504_14355 ENOG4108SF5 RNA Polymerase AL504_14365 ENOG4105F6U Short-chain dehydrogenase reductase Sdr AL504_14380 ENOG41066T0 asmA family AL504_14385 ENOG4105E0M Sulfatase AL504_14390 ENOG4108R3E Dna-3-methyladenine glycosylase i AL504_14410 ENOG41090R7 Ferric uptake AL504_14420 ENOG4106P55 Transcriptional regulator AL504_14425 ENOG4105C8Q Methyl-accepting chemotaxis AL504_14455 ENOG4107QZV Type I secretion membrane fusion protein AL504_14475 ENOG4105D01 (LipO)protein AL504_14480 ENOG4108UMI ABC transporter, permease AL504_14485 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AL504_14490 ENOG4105CJQ hydrolase, family 31 AL504_14495 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AL504_14505 ENOG4105CEY Amp-dependent synthetase and ligase AL504_14510 ENOG4105CH2 amidohydrolase AL504_14525 ENOG4105HMI Membrane AL504_14530 ENOG4105NAU thioesterase Superfamily protein AL504_14535 ENOG4105CJW magnesium transporter AL504_14550 ENOG4108XM1 transcriptional regulator AsnC family AL504_14565 ENOG4105C7K acetolactate synthase AL504_14585 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AL504_14590 ENOG4105DR5 peptidase AL504_14600 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AL504_14605 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AL504_14610 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AL504_14615 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AL504_14620 ENOG4105CPF Cell wall formation (By similarity) AL504_14625 ENOG4105DFU Cell wall formation (By similarity) AL504_14630 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AL504_14640 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AL504_14645 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AL504_14650 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AL504_14655 ENOG4105CJN penicillin-binding protein AL504_14660 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AL504_14665 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AL504_14670 ENOG4108V6E Cell division protein mraZ AL504_14680 ENOG4105C5H ABC transporter AL504_14685 ENOG4105EKE dihydroorotase AL504_14690 ENOG4105CH2 amidohydrolase AL504_14700 ENOG4105ETT transcriptional Regulator, LysR family AL504_14740 ENOG4105EW9 transcriptional regulator AsnC family AL504_14750 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AL504_14755 ENOG4105W2Z cytochrome C, class I AL504_14760 ENOG4105C01 Dihydroxy-acid dehydratase AL504_14800 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL504_14805 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL504_14810 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AL504_14815 ENOG4105EXG Transcriptional regulator AL504_14820 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AL504_14855 ENOG4107YD3 Thioesterase AL504_14860 ENOG4105E02 MotA TolQ exbB proton channel AL504_14865 ENOG4105M8F Biopolymer transport protein exbD tolR AL504_14875 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AL504_14880 ENOG4105KCK Peptidoglycan-associated lipoprotein AL504_14890 ENOG4105EHG Permease protein AL504_14895 ENOG4105E0A ABC, transporter AL504_14910 ENOG4108YXU transcriptional regulator AsnC family AL504_14920 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL504_14935 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL504_14940 ENOG4105T38 integral membrane protein AL504_14950 ENOG41067MG lrgb family AL504_14955 ENOG4105VAW lrga family AL504_14960 ENOG4105CMU LysR family (Transcriptional regulator AL504_14970 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AL504_14975 ENOG4105C0Z ABC transporter AL504_14980 ENOG4108IV0 ABC, transporter AL504_14990 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_15010 ENOG4105CR8 Transcriptional regulator AL504_15025 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AL504_15040 ENOG4105D6U Sodium Glutamate Symporter AL504_15055 ENOG4108UPT UPF0178 protein AL504_15065 ENOG4107RZZ dna polymerase iii epsilon subunit AL504_15070 ENOG4105BZS acriflavin resistance protein AL504_15080 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AL504_15085 ENOG4105D1A Methyltransferase AL504_15090 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AL504_15095 ENOG4105E9H Lytic Murein transglycosylase AL504_15100 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AL504_15120 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AL504_15135 ENOG41083UI stage II sporulation protein AL504_15140 ENOG4105JGF anti-sigma regulatory factor serine threonine protein kinase AL504_15145 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AL504_15170 ENOG4105EMN RNA polymerase sigma factor AL504_15205 ENOG4105DD5 Flagellar motor switch protein AL504_15350 ENOG4108Z33 Thiol disulfide Interchange Protein AL504_15360 ENOG4105MDS 4-oxalocrotonate tautomerase AL504_15375 ENOG4105ED1 spovr family AL504_15380 ENOG4106AKX UPF0229 protein AL504_15385 ENOG4105CYN Serine protein kinase AL504_15400 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AL504_15405 ENOG4108RWI nicotinamidase AL504_15415 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AL504_15420 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AL504_15425 ENOG4105N14 lysine exporter protein LysE YggA AL504_15435 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AL504_15445 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AL504_15450 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AL504_15460 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AL504_15465 ENOG4108UJD 30S ribosomal protein S9 AL504_15470 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AL504_15475 ENOG4108IV0 ABC, transporter AL504_15480 ENOG4105C0Z ABC transporter AL504_15485 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AL504_15490 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_15505 ENOG4105CMS peptidase U62, modulator of DNA gyrase AL504_15510 ENOG4105N42 UPF0307 protein AL504_15530 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AL504_15535 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AL504_15540 ENOG4105CD5 CoA-binding domain protein AL504_15545 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AL504_15560 ENOG4105DND Transcriptional regulator AL504_15575 ENOG4108YXU transcriptional regulator AsnC family AL504_15585 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AL504_15590 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AL504_15605 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) AL504_15610 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AL504_15635 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AL504_15645 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AL504_15650 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AL504_15655 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AL504_15660 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AL504_15665 ENOG4107QX9 Thiol disulfide interChange protein AL504_15670 ENOG4105DFU Cell wall formation (By similarity) AL504_15675 ENOG4105IPS esterase AL504_15690 ENOG4105DHQ Histidine kinase AL504_15700 ENOG4107Z33 ABC transporter, permease AL504_15715 ENOG4105E2X shikimate dehydrogenase AL504_15720 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AL504_15730 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AL504_15740 ENOG4105CDA abc transporter atp-binding protein AL504_15755 ENOG4106PMH Extracellular solute-binding protein family 3 AL504_15760 ENOG4105CHM Aminotransferase AL504_15765 ENOG4105JSC dimethylmenaquinone methyltransferase AL504_15775 ENOG4108Z20 Acyl-transferase AL504_15780 ENOG4105CD3 dihydroorotase AL504_15790 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AL504_15795 ENOG4108UJU UPF0301 protein AL504_15800 ENOG4105VCQ rubredoxin AL504_15810 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AL504_15815 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AL504_15820 ENOG4105E4C Lytic transglycosylase catalytic AL504_15830 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AL504_15835 ENOG4105D3W isochorismatase AL504_15840 ENOG4108SBK dioxygenase, subunit beta AL504_15845 ENOG4105FUY alpha subunit AL504_15885 ENOG4108UKI Enoyl-CoA hydratase AL504_15900 ENOG4105BZU Histidine kinase AL504_15905 ENOG4105BZU Histidine kinase AL504_15925 ENOG4108IV0 ABC, transporter AL504_15930 ENOG4105C0Z ABC transporter AL504_15935 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AL504_15940 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_15960 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AL504_15985 ENOG4105MWK D-amino acid dehydrogenase, small subunit AL504_15995 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AL504_16010 ENOG4105ENT Efflux transporter rnd family, mfp subunit AL504_16015 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) AL504_16020 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AL504_16040 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AL504_16045 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AL504_16055 ENOG4105C0R drug resistance transporter emrb qaca subfamily AL504_16060 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AL504_16090 ENOG4105CQC Prephenate dehydratase AL504_16095 ENOG4105JN3 extra-cytoplasmic solute receptor family protein AL504_16100 ENOG4105CBX hi0933 family AL504_16105 ENOG4105MSY salicylate hydroxylase AL504_16130 ENOG4105CDA abc transporter atp-binding protein AL504_16135 ENOG4105DRP amino acid AbC transporter AL504_16140 ENOG4105EZ7 amino acid ABC transporter AL504_16145 ENOG4107QXX ABC transporter AL504_16150 ENOG4105CAK Cell division ATP-binding protein ftsE AL504_16155 ENOG4105CRP Part of the ABC transporter FtsEX involved in AL504_16160 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) AL504_16165 ENOG4105ECQ AraC Family Transcriptional Regulator AL504_16200 ENOG4105CEN a g-specific adenine glycosylase AL504_16220 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AL504_16250 ENOG4105DEI Mannitol dehydrogenase AL504_16255 ENOG4105CXK mandelate racemase muconate lactonizing AL504_16260 ENOG4105CDA abc transporter atp-binding protein AL504_16265 ENOG4105EAD ABC transporter AL504_16270 ENOG4105E5Q amino acid AbC transporter AL504_16275 ENOG4105CPQ Dehydrogenase AL504_16290 ENOG4107YCY Transcriptional regulator AL504_16295 ENOG4105C3R Methionine synthase AL504_16300 ENOG4105D05 Receptor AL504_16305 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AL504_16310 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AL504_16315 ENOG4105DWF phosphomethylpyrimidine kinase AL504_16320 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AL504_16325 ENOG4105DFG type I secretion outer membrane protein AL504_16330 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AL504_16340 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AL504_16355 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AL504_16360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL504_16365 ENOG4105BZU Histidine kinase AL504_16385 ENOG4105E3B Multicopper oxidase AL504_16400 ENOG4108JQ1 Dehydrogenase AL504_16430 ENOG4105DUM transcriptional regulator, lysR family AL504_16440 ENOG4105P4J Allophanate hydrolase, subunit 1 AL504_16450 ENOG4105E7W lamb ycsf family protein AL504_16455 ENOG4105DRR Transcriptional regulator, GntR family AL504_16460 ENOG4105EN6 Membrane AL504_16470 ENOG4105EYM Major Facilitator superfamily AL504_16475 ENOG4105DWV Homoserine O-trans-acetylase AL504_16480 ENOG4105DWV Homoserine O-trans-acetylase AL504_16485 ENOG4105FDP GntR family transcriptional regulator AL504_16490 ENOG4105VP7 SAF domain protein AL504_16495 ENOG4105CTX dehydratase AL504_16505 ENOG4108JQ1 Dehydrogenase AL504_16510 ENOG4105DG4 malate L-lactate dehydrogenase AL504_16540 ENOG4105D9M gamma-glutamylcysteine synthetase AL504_16550 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) AL504_16560 ENOG4105DND Transcriptional regulator AL504_16570 ENOG4107XBN GntR Family Transcriptional Regulator AL504_16580 ENOG4108IV0 ABC, transporter AL504_16585 ENOG4105C2J ABC transporter AL504_16590 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AL504_16595 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_16605 ENOG4105ERH Fumarylacetoacetate hydrolase AL504_16620 ENOG4108Z9W Outer membrane porin AL504_16645 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL504_16660 ENOG4105KBX Transcriptional regulator, TetR family AL504_16670 ENOG4105E39 Enoyl-CoA hydratase AL504_16675 ENOG41060WC Enoyl-CoA hydratase AL504_16680 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AL504_16690 ENOG4105DEF Extracellular solute-binding protein, family 5 AL504_16695 ENOG4105EMY transcriptional regulator AL504_16705 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) AL504_16710 ENOG4107QSI ABC, transporter AL504_16725 ENOG4105C3U ABC transporter AL504_16730 ENOG4108JQ7 (ABC) transporter AL504_16740 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AL504_16745 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) AL504_16750 ENOG4105ECQ AraC Family Transcriptional Regulator AL504_16755 ENOG4105EMU Dehydrogenase AL504_16760 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AL504_16775 ENOG4105C4R Atp-dependent dna helicase AL504_16780 ENOG4105C25 Primosomal protein n' AL504_16785 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AL504_16795 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AL504_16800 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AL504_16805 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AL504_16810 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AL504_16815 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AL504_16820 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AL504_16825 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AL504_16830 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) AL504_16845 ENOG4105E39 Enoyl-CoA hydratase AL504_16860 ENOG4107QNJ CoA-transferase subunit B AL504_16875 ENOG4106NZI LysR family Transcriptional regulator AL504_16880 ENOG4105RE0 Asp Glu hydantoin racemase AL504_16890 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein AL504_16905 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) AL504_16910 ENOG4105CJ1 ABC, transporter AL504_16915 ENOG4105C0Z ABC transporter AL504_16920 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_16925 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_16945 ENOG4105EQ1 Transcriptional regulator AL504_16950 ENOG4105F2Z 3-oxoadipate enol-lactonase AL504_16960 ENOG4105C3M thioredoxin reductase AL504_16970 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AL504_16980 ENOG4105T95 Thiol disulfide interChange protein AL504_16985 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AL504_16995 ENOG4105NWN ApaG protein AL504_17005 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AL504_17015 ENOG4105DDQ anthranilate synthase AL504_17020 ENOG4108I0Q anthranilate phosphoribosyltransferase AL504_17025 ENOG4105DK0 Indole-3-glycerol phosphate synthase AL504_17030 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AL504_17035 ENOG4105C26 Dehydrogenase AL504_17055 ENOG4105ETT transcriptional Regulator, LysR family AL504_17065 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) AL504_17070 ENOG4108KS2 transglutaminase domain protein AL504_17075 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AL504_17090 ENOG4105EM7 Selenocysteine-specific translation elongation factor AL504_17095 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) AL504_17100 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) AL504_17105 ENOG4108MG3 formate dehydrogenase AL504_17110 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AL504_17115 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AL504_17120 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AL504_17165 ENOG4105X1Q TOBE domain protein AL504_17170 ENOG4105E2Y ABC, transporter AL504_17175 ENOG4105D01 (LipO)protein AL504_17180 ENOG4108UMI ABC transporter, permease AL504_17190 ENOG4107T8P acyl-Coa dehydrogenase AL504_17195 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AL504_17200 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AL504_17205 ENOG4105GVF (ABC) transporter AL504_17210 ENOG4108UZX fmn reductase AL504_17215 ENOG4105D01 (LipO)protein AL504_17225 ENOG4107T8P acyl-Coa dehydrogenase AL504_17230 ENOG4107T8P acyl-Coa dehydrogenase AL504_17240 ENOG4105DEF Extracellular solute-binding protein, family 5 AL504_17250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL504_17260 ENOG41081QV Universal stress protein AL504_17275 ENOG4105C26 Dehydrogenase AL504_17290 ENOG4105DRR Transcriptional regulator, GntR family AL504_17365 ENOG4105C0R drug resistance transporter emrb qaca subfamily AL504_17370 ENOG4105C8Q Methyl-accepting chemotaxis AL504_17385 ENOG4105ETS cytosine purines uracil thiamine allantoin AL504_17390 ENOG4105CGP Urocanate hydratase AL504_17395 ENOG41090B9 response to stress AL504_17400 ENOG4105CZE histidine utilization repressor AL504_17415 ENOG4105CGH 5'-nucleotidase AL504_17465 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AL504_17470 ENOG4105CYW agmatinase AL504_17480 ENOG4105EVZ LysR family transcriptional regulator AL504_17485 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AL504_17490 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AL504_17500 ENOG4107QWB Ornithine cyclodeaminase AL504_17505 ENOG4105EJC lysr family transcriptional regulator AL504_17510 ENOG4105EQ0 Major Facilitator superfamily AL504_17520 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AL504_17535 ENOG4105CPU Monooxygenase AL504_17540 ENOG4105E0A ABC, transporter AL504_17545 ENOG4105TVJ transport system, permease AL504_17550 ENOG4105DQ5 transport system permease protein AL504_17555 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein AL504_17560 ENOG4105E0K tonB-dependent siderophore receptor AL504_17565 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions AL504_17580 ENOG4105MXW flavin reductase domain protein, FMN-binding AL504_17585 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AL504_17595 ENOG4108SF5 RNA Polymerase AL504_17610 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AL504_17635 ENOG4105C6Y Udp-glucose 6-dehydrogenase AL504_17640 ENOG4105C0R drug resistance transporter emrb qaca subfamily AL504_17645 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AL504_17670 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AL504_17675 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) AL504_17695 ENOG4107QS1 Cytochrome C Oxidase, Subunit III AL504_17705 ENOG4105BZ9 Cytochrome C oxidase, subunit I AL504_17710 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) AL504_17725 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AL504_17730 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL504_17785 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AL504_17790 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AL504_17795 ENOG4105E7W lamb ycsf family protein AL504_17800 ENOG4105DND Transcriptional regulator AL504_17805 ENOG4105EIF outer membrane protein W AL504_17810 ENOG4105EGI Transcriptional regulator AL504_17815 ENOG4105CBP Major Facilitator AL504_17825 ENOG4105EA8 2-Nitropropane dioxygenase AL504_17830 ENOG4105DHJ ABC, transporter AL504_17835 ENOG4105CY3 ABC transporter, permease AL504_17840 ENOG4107PE3 Mammalian cell entry related domain protein AL504_17845 ENOG410903C (LipO)protein AL504_17855 ENOG4105DA5 (ABC) transporter AL504_17860 ENOG4105E3A (ABC) transporter AL504_17870 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AL504_17875 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AL504_17880 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AL504_17885 ENOG4105CIH Imidazole acetol-phosphate transaminase AL504_17890 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AL504_17895 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AL504_17900 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AL504_17905 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AL504_17910 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AL504_17915 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase AL504_17920 ENOG4107YU2 histidine triad (hIT) protein AL504_17925 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AL504_17930 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AL504_17945 ENOG4105C0H protease AL504_17950 ENOG4107QNR UPF0135 protein AL504_17955 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AL504_17960 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AL504_17965 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AL504_17970 ENOG4105EIX cytochrome c1 AL504_17975 ENOG4107MKT Stringent starvation protein a AL504_17980 ENOG4105KB2 stringent starvation protein b AL504_18020 ENOG4106H6R UPF0380 protein AL504_18075 ENOG4107QJE Chromosome Partitioning Protein AL504_18110 ENOG4105E39 Enoyl-CoA hydratase AL504_18115 ENOG4105CHU acetyl-coa acetyltransferase AL504_18120 ENOG4105CEY Amp-dependent synthetase and ligase AL504_18130 ENOG4105C1G acyl-Coa dehydrogenase AL504_18145 ENOG4105D2S major facilitator superfamily AL504_18150 ENOG4105CSU acyl-Coa dehydrogenase AL504_18155 ENOG4108Z7G MaoC domain protein dehydratase AL504_18160 ENOG4105BZJ Electron transfer flavoprotein AL504_18165 ENOG4105C10 Electron transfer flavoprotein AL504_18170 ENOG4106NZI LysR family Transcriptional regulator AL504_18250 ENOG4105C6Z Gluconate AL504_18265 ENOG4105ETT transcriptional Regulator, LysR family AL504_18275 ENOG4105C9B Cysteine desulfurase AL504_18285 ENOG4105UEI Transcriptional Regulator AraC Family AL504_18295 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AL504_18300 ENOG4105DEF Extracellular solute-binding protein, family 5 AL504_18305 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AL504_18310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL504_18315 ENOG4108JQ6 ABC transporter AL504_18320 ENOG4105CI2 imidazolone-5-propionate hydrolase AL504_18325 ENOG4106J39 exported protein AL504_18330 ENOG4106J39 exported protein AL504_18335 ENOG4105C1J atp-dependent rna helicase AL504_18345 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AL504_18355 ENOG4108UQY Iron-storage protein AL504_18380 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AL504_18395 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AL504_18405 ENOG4105ETE Transcriptional regulator (LacI family AL504_18410 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AL504_18420 ENOG4105BZ7 extracellular solute-binding protein family 1 AL504_18425 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AL504_18430 ENOG4105DRS transport system, permease AL504_18465 ENOG4105C75 arginyL-tRNA synthetase AL504_18475 ENOG4108Z33 Thiol disulfide Interchange Protein AL504_18485 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL504_18500 ENOG410829K Lysine exporter protein (Lyse ygga) AL504_18515 ENOG4105KK4 UPF0060 membrane protein AL504_18530 ENOG4105CH2 amidohydrolase AL504_18535 ENOG4105C1G acyl-Coa dehydrogenase AL504_18540 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) AL504_18545 ENOG4105CHU acetyl-coa acetyltransferase AL504_18550 ENOG4107QX3 carboxylase AL504_18570 ENOG4105E8G Major facilitator Superfamily AL504_18600 ENOG4105CHR reductase AL504_18615 ENOG4105CEY Amp-dependent synthetase and ligase AL504_18620 ENOG4108SF5 RNA Polymerase AL504_18650 ENOG4105D3W isochorismatase AL504_18655 ENOG410829K Lysine exporter protein (Lyse ygga) AL504_18680 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system AL504_18705 ENOG4105ECQ AraC Family Transcriptional Regulator AL504_18725 ENOG4108SF5 RNA Polymerase AL504_18730 ENOG4108S3W Anti-feci sigma factor, fecr AL504_18740 ENOG4105C8Y Acetylornithine aminotransferase AL504_18760 ENOG4108R86 Transcriptional regulator AL504_18765 ENOG4106TNF Periplasmic binding protein AL504_18770 ENOG4105E5Q amino acid AbC transporter AL504_18775 ENOG4105E5Q amino acid AbC transporter AL504_18805 ENOG4108RPN Protein smg homolog AL504_18810 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AL504_18820 ENOG4105C9U ATP-dependent DNA helicase RecQ AL504_18835 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component AL504_18840 ENOG4105CHR reductase AL504_18845 ENOG4105C7K acetolactate synthase AL504_18850 ENOG4108YXU transcriptional regulator AsnC family AL504_18855 ENOG4105FFC UPF0187 protein AL504_18865 ENOG4107RDF Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AL504_18870 ENOG4105F9N Major Facilitator Superfamily AL504_18885 ENOG4108MEJ flavin reductase domain protein AL504_18900 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AL504_18910 ENOG4107TFB basic membrane AL504_18915 ENOG4108JQ9 ABC transporter AL504_18920 ENOG4105UIB (ABC) transporter AL504_18930 ENOG4105DZC cytosine deaminase AL504_18940 ENOG4105MWK D-amino acid dehydrogenase, small subunit AL504_18945 ENOG4105RQF LysR family Transcriptional regulator AL504_18950 ENOG4105M4H endoribonuclease L-psp AL504_18975 ENOG4105D38 putrescine abc transporter AL504_18980 ENOG4105F38 ABC transporter, permease AL504_18985 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL504_18995 ENOG4105CMD Transcriptional regulator, GntR family AL504_19025 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AL504_19050 ENOG4105D38 putrescine abc transporter AL504_19055 ENOG4105F38 ABC transporter, permease AL504_19075 ENOG4105DMF Dehydrogenase AL504_19085 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AL504_19090 ENOG4108594 Permease of the drug metabolite transporter AL504_19100 ENOG4105CDA abc transporter atp-binding protein AL504_19105 ENOG4105DRP amino acid AbC transporter AL504_19110 ENOG4105EAD ABC transporter AL504_19115 ENOG4107RP9 extracellular solute-binding protein, family 3 AL504_19120 ENOG4105RQF LysR family Transcriptional regulator AL504_19130 ENOG4105EFZ amidohydrolase AL504_19140 ENOG4105C2I pirin domain protein AL504_19155 ENOG4105CC0 LysR family Transcriptional regulator AL504_19160 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AL504_19165 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AL504_19170 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AL504_19175 ENOG4105VG0 50S ribosomal protein l34 AL504_19190 ENOG4105CH6 catalase AL504_19195 ENOG4105C6T cysteine synthase AL504_19205 ENOG4108S3W Anti-feci sigma factor, fecr AL504_19220 ENOG4105CH2 amidohydrolase AL504_19225 ENOG4108JQ7 (ABC) transporter AL504_19230 ENOG4105C3U ABC transporter AL504_19235 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL504_19250 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AL504_19290 ENOG4105CHM Aminotransferase AL504_19295 ENOG4108KK1 membrane protein AbrB duplication AL504_19300 ENOG4105VEQ Cold shock protein AL504_19305 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AL504_19310 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AL504_19315 ENOG4107QJE Chromosome Partitioning Protein AL504_19325 ENOG4105FA0 parb-like partition protein AL504_19330 ENOG4105HDK L-asparaginase AL504_19335 ENOG4107NQ8 LysR family Transcriptional regulator AL504_19360 ENOG4105E98 transcriptional regulator DeoR family AL504_19370 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL504_19375 ENOG4107QKW extracellular solute-binding protein family 1 AL504_19415 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AL504_19425 ENOG410683Z Preprotein translocase SecE subunit AL504_19435 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AL504_19440 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AL504_19445 ENOG4108VZM 50s ribosomal protein L10 AL504_19450 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AL504_19455 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL504_19460 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL504_19475 ENOG4105BZU Histidine kinase AL504_19490 ENOG4107EXC regulatoR AL504_19495 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AL504_19500 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AL504_19505 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AL504_19510 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AL504_19515 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AL504_19520 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AL504_19525 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AL504_19530 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AL504_19535 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AL504_19540 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AL504_19545 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AL504_19550 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AL504_19555 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AL504_19560 ENOG41084PQ 50s ribosomal protein l29 AL504_19565 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AL504_19575 ENOG4105D75 Capsular exopolysaccharide family AL504_19580 ENOG4105VFN O-Antigen polymerase AL504_19645 ENOG4105D3Q Sugar transferase AL504_19670 ENOG4107QZ7 Cellulose synthase catalytic subunit AL504_19675 ENOG4107EEX Cellulose synthase regulator protein AL504_19680 ENOG4107EEX Cellulose synthase regulator protein AL504_19685 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) AL504_19690 ENOG4105EJG cellulose synthase AL504_19705 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AL504_19710 ENOG4105JHR Alginate biosynthesis protein AlgX AL504_19725 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AL504_19730 ENOG4108IV0 ABC, transporter AL504_19735 ENOG4105C0Z ABC transporter AL504_19750 ENOG4108WFR AraC Family Transcriptional Regulator AL504_19770 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AL504_19775 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AL504_19780 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AL504_19785 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AL504_19790 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AL504_19795 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AL504_19800 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AL504_19805 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AL504_19810 ENOG4105VPB 50S ribosomal protein L30 AL504_19815 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AL504_19820 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AL504_19825 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AL504_19830 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AL504_19835 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AL504_19840 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AL504_19845 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AL504_19850 ENOG4108ZT0 50S ribosomal protein l17 AL504_19860 ENOG4105VF7 tolerance protein AL504_19865 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AL504_19875 ENOG4105D52 delta-aminolevulinic acid dehydratase AL504_19880 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AL504_19890 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) AL504_19895 ENOG4105CRE cytochrome C AL504_19900 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AL504_19905 ENOG4105XQ6 frataxin-like protein AL504_19910 ENOG4108JQC penicillin-binding protein 1A AL504_19915 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AL504_19920 ENOG4105D49 3-dehydroquinate synthase AL504_19925 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AL504_19930 ENOG4108RXX maleylacetoacetate isomerase AL504_19935 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AL504_19940 ENOG4107RDB Major Facilitator AL504_19945 ENOG4108UUM single-stranded DNA-binding protein AL504_19950 ENOG4105DMQ Methyltransferase AL504_19980 ENOG4107QP3 malate synthase g AL504_19985 ENOG4108KWP DNA-binding transcriptional regulator GlcC AL504_20010 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL504_20015 ENOG4108ZGC gaf domain protein AL504_20020 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AL504_20035 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AL504_20060 ENOG4105C9M aspartyl-trna synthetase AL504_20065 ENOG4105X23 Endonuclease Exonuclease phosphatase AL504_20070 ENOG4105DZQ phospholipase D Transphosphatidylase AL504_20105 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AL504_20110 ENOG4105ESV Glycosyl transferase, family 4 AL504_20145 ENOG4105EY8 ABC transporter AL504_20155 ENOG4108R85 Short chain dehydrogenase AL504_20160 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AL504_20170 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AL504_20180 ENOG4108S0S Nucleotidyl transferase AL504_20190 ENOG4105D2T synthase AL504_20195 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase AL504_20200 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AL504_20205 ENOG4105C1B dTDP-glucose 4-6-dehydratase AL504_20225 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) AL504_20230 ENOG4105D3Q Sugar transferase AL504_20235 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AL504_20245 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AL504_20250 ENOG4105J5G Transferase hexapeptide repeat containing protein AL504_20255 ENOG4105CK5 oxidoreductase AL504_20260 ENOG4105D16 lipopolysaccharide heptosyltransferase i AL504_20265 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AL504_20270 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AL504_20280 ENOG4105CY3 ABC transporter, permease AL504_20305 ENOG4105DZ1 carboxypeptidase AL504_20315 ENOG4108Z43 UPF0250 protein AL504_20320 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AL504_20335 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AL504_20340 ENOG4108WBT adenosyltransferase AL504_20350 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AL504_20355 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AL504_20360 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AL504_20365 ENOG4105CKI cobalamin synthesis protein AL504_20370 ENOG4105MYN Zinc uptake regulation protein AL504_20375 ENOG4105DIK (ABC) transporter AL504_20380 ENOG4105CC5 ABC transporter AL504_20385 ENOG4105DSE periplasmic solute binding protein AL504_20395 ENOG4105D7X high-affinity nickel-transporter AL504_20400 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL504_20410 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AL504_20415 ENOG4105D1S lipid A biosynthesis AL504_20425 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AL504_20430 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AL504_20435 ENOG4105CSH Transporter AL504_20445 ENOG4105EJC lysr family transcriptional regulator AL504_20460 ENOG4108TFY Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AL504_20475 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AL504_20480 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AL504_20485 ENOG41086DT Membrane protein of unknown function AL504_20490 ENOG4105SYT Methylenetetrahydrofolate reductase AL504_20520 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AL504_20525 ENOG4107SC1 transglycosylase AL504_20540 ENOG4105C1J atp-dependent rna helicase AL504_20545 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AL504_20555 ENOG4105CKT filamentous hemagglutinin AL504_20555 ENOG4105CKT filamentous hemagglutinin AL504_20565 ENOG4105DWF phosphomethylpyrimidine kinase AL504_20600 ENOG4105K78 MarR family Transcriptional regulator AL504_20605 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AL504_20620 ENOG4105CSR polyphosphate kinase 2 AL504_20630 ENOG41080HT Transcriptional regulator, arsr family AL504_20650 ENOG4105DZS Phenylacetate-CoA ligase AL504_20655 ENOG4108IV0 ABC, transporter AL504_20670 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_20675 ENOG4105C0Z ABC transporter AL504_20690 ENOG4105K56 Transcriptional regulator AL504_20695 ENOG4108ZHJ Organic hydroperoxide resistance protein AL504_20705 ENOG4108IV0 ABC, transporter AL504_20710 ENOG4105C0Z ABC transporter AL504_20720 ENOG4105CP9 extracellular ligand-binding receptor AL504_20725 ENOG410810E transcriptional regulator, lysR family AL504_20740 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AL504_20750 ENOG4105D82 Glutamate dehydrogenase AL504_20755 ENOG4105CGK Exodeoxyribonuclease III AL504_20760 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AL504_20770 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AL504_20775 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AL504_20780 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AL504_20785 ENOG4105DFF Rod shape-determining protein mreb AL504_20790 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AL504_20800 ENOG4105CJN penicillin-binding protein AL504_20805 ENOG4105CNI cell division protein FtsW AL504_20815 ENOG4105DG4 malate L-lactate dehydrogenase AL504_20820 ENOG4107QPK )-transporter AL504_20825 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AL504_20835 ENOG4105CAS nag kinase AL504_20840 ENOG4105D01 (LipO)protein AL504_20845 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AL504_20850 ENOG4105W4M Transport-associated protein AL504_20855 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AL504_20860 ENOG41082RQ UPF0102 protein AL504_20870 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AL504_20880 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AL504_20895 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL504_20900 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) AL504_20905 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AL504_20910 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA AL504_20915 ENOG4108IUZ ABC transporter AL504_20930 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase AL504_20935 ENOG4105C2X Arabinose 5-phosphate isomerase AL504_20940 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AL504_20950 ENOG4105C4M (Ubiquinol oxidase) subunit I AL504_20955 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL504_20960 ENOG4108JJ9 ABC, transporter AL504_20965 ENOG4108JJ8 (ABC) transporter AL504_20970 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AL504_20975 ENOG4105EXG Transcriptional regulator AL504_20985 ENOG4108Z9W Outer membrane porin AL504_20990 ENOG4105C7B Threonine dehydratase AL504_20995 ENOG4105W39 Membrane AL504_21015 ENOG4105DFA alanine racemase domain protein AL504_21020 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL504_21025 ENOG4107QXX ABC transporter AL504_21035 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AL504_21040 ENOG4105C79 DNA protecting protein DprA AL504_21045 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AL504_21050 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AL504_21060 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AL504_21070 ENOG4108URH decarboxylase AL504_21080 ENOG4105KVH Transcriptional regulator AL504_21085 ENOG4105KPY Small multidrug resistance protein AL504_21100 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AL504_21110 ENOG4105ES5 Histidine kinase AL504_21115 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL504_21120 ENOG4105C1A potassium transporter peripheral membrane AL504_21125 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AL504_21130 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) AL504_21135 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AL504_21155 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AL504_21160 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) AL504_21165 ENOG4105VW4 glutaredoxin 3 AL504_21170 ENOG4105C72 UPF0176 protein AL504_21175 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AL504_21180 ENOG41063SB peptidase AL504_21185 ENOG4105CN1 protease AL504_21190 ENOG4105D06 uba thif-type nad fad binding protein AL504_21195 ENOG4105BZU Histidine kinase AL504_21200 ENOG4108QBF Transcriptional regulator AL504_21210 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AL504_21215 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL504_21230 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AL504_21235 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AL504_21240 ENOG4105K46 50S ribosomal protein l27 AL504_21245 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AL504_21250 ENOG4105EAH synthase AL504_21265 ENOG4105CIF Ornithine Cyclodeaminase AL504_21275 ENOG4105C84 Histidine ammonia-lyase AL504_21340 ENOG4105FB2 class II Aldolase AL504_21345 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AL504_21350 ENOG4105EXW epimerase dehydratase AL504_21355 ENOG4105ZXK Dehydrogenase AL504_21360 ENOG4105G63 Type III effector Hrp-dependent AL504_21365 ENOG4107YCY Transcriptional regulator AL504_21375 ENOG4105CSH Transporter AL504_21385 ENOG4105UGU tonB-dependent Receptor AL504_21390 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AL504_21425 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AL504_21430 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AL504_21435 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AL504_21445 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AL504_21455 ENOG4105D01 (LipO)protein AL504_21475 ENOG4105CEY Amp-dependent synthetase and ligase AL504_21500 ENOG4105C57 major facilitator superfamily AL504_21505 ENOG4107NQ8 LysR family Transcriptional regulator AL504_21530 ENOG4108U78 Glutathione S-transferase AL504_21535 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein AL504_21540 ENOG4105CHR reductase AL504_21545 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AL504_21550 ENOG4108IV0 ABC, transporter AL504_21555 ENOG4105C0Z ABC transporter AL504_21560 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AL504_21565 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_21575 ENOG4105CHR reductase AL504_21580 ENOG4108PVQ transcriptional regulator AL504_21605 ENOG4105F2Z 3-oxoadipate enol-lactonase AL504_21615 ENOG4105NN7 muconolactone delta-isomerase AL504_21620 ENOG4107QNJ CoA-transferase subunit B AL504_21630 ENOG4107HP6 Transcriptional regulator AL504_21635 ENOG4105CHR reductase AL504_21640 ENOG4105CRW Short chain fatty acid transporter AL504_21645 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL504_21650 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AL504_21655 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AL504_21675 ENOG4105DUM transcriptional regulator, lysR family AL504_21680 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AL504_21695 ENOG4105C01 Dihydroxy-acid dehydratase AL504_21700 ENOG4105HEI LysR family (Transcriptional regulator AL504_21705 ENOG4107QN2 dihydrolipoyl dehydrogenase AL504_21720 ENOG4108JYK Dehydrogenase AL504_21730 ENOG4108IV0 ABC, transporter AL504_21735 ENOG4105C0Z ABC transporter AL504_21745 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_21755 ENOG4105E2X shikimate dehydrogenase AL504_21765 ENOG4107YCY Transcriptional regulator AL504_21775 ENOG4105GP2 5'(3')-deoxyribonucleotidase AL504_21785 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AL504_21795 ENOG4105ENT Efflux transporter rnd family, mfp subunit AL504_21800 ENOG4105CBN LysR family transcriptional regulator AL504_21805 ENOG4105IPI Membrane AL504_21830 ENOG4105NTW Transcriptional regulator AL504_21840 ENOG4106NZI LysR family Transcriptional regulator AL504_21860 ENOG4105I6B RNA polymerase AL504_21870 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL504_21985 ENOG4106P55 Transcriptional regulator AL504_21990 ENOG4105CHR reductase AL504_22005 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AL504_22010 ENOG4105CNN ABC, transporter AL504_22020 ENOG4105C2J ABC transporter AL504_22030 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AL504_22035 ENOG4107QXX ABC transporter AL504_22060 ENOG4105C2W permease AL504_22070 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AL504_22085 ENOG4105F27 Major Facilitator AL504_22105 ENOG4105CJ1 ABC, transporter AL504_22110 ENOG4105DJB Major Facilitator Superfamily AL504_22115 ENOG4105CXK mandelate racemase muconate lactonizing AL504_22120 ENOG4108RTU Aldolase AL504_22130 ENOG4107HP6 Transcriptional regulator AL504_22150 ENOG4105CAF HipA N-terminal domain protein AL504_22165 ENOG4108JJ6 Type I secretion system ATPase AL504_22170 ENOG4107QZV Type I secretion membrane fusion protein AL504_22180 ENOG4107RSM transcriptional regulator AL504_22185 ENOG4105C26 Dehydrogenase AL504_22205 ENOG4108TGY Glutathione S-transferase AL504_22220 ENOG4105CRE cytochrome C AL504_22225 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AL504_22230 ENOG4109066 lysm domain bon superfamily protein AL504_22245 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AL504_22255 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AL504_22265 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AL504_22270 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AL504_22300 ENOG4105EVD ribosomal RNA large subunit methyltransferase N AL504_22320 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme AL504_22325 ENOG4105CHR reductase AL504_22335 ENOG4105CSH Transporter AL504_22365 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase AL504_22380 ENOG4105JJR Histidine kinase AL504_22400 ENOG4105CH7 arginosuccinase AL504_22410 ENOG4105C7F AcnD-accessory protein PrpF AL504_22415 ENOG4108I0Z Aconitate hydratase AL504_22425 ENOG4105YK5 50S ribosomal protein L36 AL504_22430 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase AL504_22435 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AL504_22450 ENOG4105FN4 Depolymerizes alginate by cleaving the beta-1,4 glycosidic bond (By similarity) AL504_22475 ENOG4105CD3 dihydroorotase AL504_22490 ENOG4105CGP Urocanate hydratase AL504_22495 ENOG4105CSH Transporter AL504_22500 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AL504_22510 ENOG4105CYM Glutathione S-transferase AL504_22520 ENOG4105NQN cytochrome C AL504_22535 ENOG41079YP Citrate utilization protein b AL504_22555 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL504_22560 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AL504_22565 ENOG4105C4M (Ubiquinol oxidase) subunit I AL504_22570 ENOG4105VSH 4-oxalocrotonate tautomerase AL504_22575 ENOG4105CHR reductase AL504_22580 ENOG4105JQN Transcriptional regulator AL504_22585 ENOG4108KTG Membrane protein, drug metabolite transporter AL504_22590 ENOG4105EXG Transcriptional regulator AL504_22595 ENOG4105CHR reductase AL504_22605 ENOG4105CMI transporter AL504_22610 ENOG4105CJ1 ABC, transporter AL504_22615 ENOG4105D0S secretion protein (HlyD AL504_22620 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AL504_22625 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class AL504_22635 ENOG4105E0K tonB-dependent siderophore receptor AL504_22645 ENOG4108SF5 RNA Polymerase AL504_22650 ENOG4105CXC rtn protein AL504_22670 ENOG4108ZVF (LipO)protein AL504_22675 ENOG4107SVH Potassium channel protein AL504_22680 ENOG4105XJC Two component transcriptional regulator (Winged helix family AL504_22690 ENOG4105EXC Acyl-transferase AL504_22705 ENOG4105C72 UPF0176 protein AL504_22710 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AL504_22735 ENOG4105DHP deoxycytidine triphosphate deaminase AL504_22745 ENOG4105BZU Histidine kinase AL504_22760 ENOG4105CXN decarboxylase AL504_22765 ENOG4105CBX hi0933 family AL504_22770 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AL504_22780 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AL504_22785 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AL504_22790 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AL504_22805 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AL504_22810 ENOG4108JQ6 ABC transporter AL504_22835 ENOG4105C26 Dehydrogenase AL504_22840 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AL504_22845 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AL504_22855 ENOG4105BZU Histidine kinase AL504_22860 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AL504_22870 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) AL504_22875 ENOG4107UKG Glycosyl transferase, family 4 AL504_22880 ENOG4107QQG Dehydrogenase AL504_22895 ENOG4105CG5 Glycosyl transferase (Group 1 AL504_22905 ENOG4108KMV Glycosyl transferase (Group 1 AL504_22910 ENOG4108KMV Glycosyl transferase (Group 1 AL504_22915 ENOG4105CGN Glycosyl transferase (Group 1 AL504_22920 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL504_22925 ENOG4107QP8 phosphohexose isomerase AL504_22940 ENOG4105CQB FAD linked oxidase domain protein AL504_22945 ENOG4105XJC Two component transcriptional regulator (Winged helix family AL504_22950 ENOG4108TAG Histidine kinase AL504_22960 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL504_22970 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AL504_22975 ENOG4105E9Z Nad-dependent epimerase dehydratase AL504_22980 ENOG4107YCY Transcriptional regulator AL504_22985 ENOG4105E0M Sulfatase AL504_22990 ENOG4106HNH Acyl-transferase AL504_23000 ENOG4105F1J Homogentisate 1,2-dioxygenase AL504_23025 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AL504_23030 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein AL504_23035 ENOG41081V9 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AL504_23040 ENOG4105C8Q Methyl-accepting chemotaxis AL504_23045 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AL504_23055 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AL504_23060 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AL504_23065 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AL504_23075 ENOG4105C3G gtp-binding protein AL504_23080 ENOG4105DFS Conserved Protein AL504_23120 ENOG4105DKK Benzoate AL504_23125 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AL504_23130 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AL504_23135 ENOG4106H78 methyltransferase AL504_23170 ENOG4105D5T phosphonate abc transporter AL504_23190 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AL504_23195 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AL504_23200 ENOG4107YIM Involved in the transcription termination process (By similarity) AL504_23205 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AL504_23215 ENOG4108I62 cina-like protein AL504_23220 ENOG4105SKN orotidine 5''-phosphate decarboxylase AL504_23225 ENOG4105CEP NADH dehydrogenase AL504_23230 ENOG41080IJ Diacylglycerol kinase AL504_23235 ENOG4105DEI Mannitol dehydrogenase AL504_23240 ENOG4108IV0 ABC, transporter AL504_23245 ENOG4108IUZ ABC transporter AL504_23275 ENOG4105DUM transcriptional regulator, lysR family AL504_23290 ENOG4105E0K tonB-dependent siderophore receptor AL504_23305 ENOG4108ZT1 Transcriptional regulator AL504_23315 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AL504_23320 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AL504_23355 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AL504_23380 ENOG4105BZN citrate synthase AL504_23400 ENOG4105CF7 AraC family transcriptional regulator AL504_23410 ENOG4107NQ8 LysR family Transcriptional regulator AL504_23425 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AL504_23435 ENOG4105BZU Histidine kinase AL504_23440 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL504_23460 ENOG4105BZU Histidine kinase AL504_23465 ENOG4108IXY short-chain dehydrogenase reductase AL504_23470 ENOG4105JQN Transcriptional regulator AL504_23500 ENOG4108IPW abc transporter atp-binding protein AL504_23535 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AL504_23580 ENOG4105JAB phenazine biosynthesis protein, phzf family AL504_23595 ENOG4105BZU Histidine kinase AL504_23600 ENOG4107Z5C methylesterase AL504_23605 ENOG4105BZU Histidine kinase AL504_23610 ENOG4105BZU Histidine kinase AL504_23615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AL504_23640 ENOG4105KHC sulfurtransferase AL504_23655 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase AL504_23660 ENOG4105CQB FAD linked oxidase domain protein AL504_23675 ENOG4105CN1 protease AL504_23695 ENOG4108MXF Alpha Beta Hydrolase AL504_23705 ENOG4105DUM transcriptional regulator, lysR family AL504_23720 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AL504_23730 ENOG4105EMN RNA polymerase sigma factor AL504_23745 ENOG4105GAV receptor AL504_23750 ENOG4108S3W Anti-feci sigma factor, fecr AL504_23755 ENOG4108SF5 RNA Polymerase AL504_23775 ENOG410642W LysR family Transcriptional regulator AL504_23780 ENOG4107RSM transcriptional regulator AL504_23800 ENOG4105CWC Acetylornithine deacetylase AL504_23805 ENOG4108PCN EamA-like transporter family AL504_23810 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AL504_23820 ENOG4105C1G acyl-Coa dehydrogenase AL504_23825 ENOG4105ETT transcriptional Regulator, LysR family AL504_23830 ENOG4105CHR reductase AL504_23855 ENOG4105DXI Major Facilitator superfamily AL504_23865 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase AL504_23890 ENOG4105CAU Arsenical resistance protein, ArsH AL504_23895 ENOG4105D6J arsenicaL-resistance protein AL504_23920 ENOG41061WM D-Alanyl-D-Alanine AL504_23930 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL504_23985 ENOG4108JQ6 ABC transporter AL504_23990 ENOG4107T0X DNA ligase AL504_23995 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) AL504_24000 ENOG4107QRT dEAD DEAH box helicase AL504_24010 ENOG4105BZ1 (ABC) transporter AL504_24065 ENOG4108S3W Anti-feci sigma factor, fecr AL504_24095 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) AL504_24120 ENOG4105MP9 class II Aldolase AL504_24130 ENOG4108M0I Transcriptional regulator AL504_24145 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AL504_24155 ENOG4105K5X acetyltransferase AL504_24160 ENOG4108WC5 Alpha Beta Hydrolase Fold protein AL504_24170 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AL504_24190 ENOG4105C6X Major Facilitator AL504_24195 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AL504_24205 ENOG4105MHT Transcriptional regulator, ARSR family AL504_24210 ENOG410620I Diguanylate cyclase AL504_24215 ENOG4105C8Q Methyl-accepting chemotaxis AL504_24240 ENOG4105CMJ mandelate racemase muconate lactonizing AL504_24245 ENOG4105EJC lysr family transcriptional regulator AL504_24250 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AL504_24265 ENOG4105HEI LysR family (Transcriptional regulator AL504_24270 ENOG4105CV8 reductase AL504_24280 ENOG4105CPC Aldo Keto reductase AL504_24290 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AL504_24295 ENOG4107QZF nitrite reductase NADPH large subunit AL504_24300 ENOG4107QZF nitrite reductase NADPH large subunit AL504_24320 ENOG4105HSS phospholipase C AL504_24330 ENOG4108T94 DNA-binding transcriptional activator BglJ AL504_24365 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) AL504_24370 ENOG4105E5M Multidrug resistance protein D AL504_24380 ENOG4108Z9W Outer membrane porin AL504_24385 ENOG4108Z9W Outer membrane porin AL504_24395 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) AL504_24400 ENOG4105CCU oxidase (Subunit III) AL504_24405 ENOG4105BZ9 Cytochrome C oxidase, subunit I AL504_24410 ENOG4105E2S oxidase) subunit II AL504_24415 ENOG4105CSH Transporter AL504_24440 ENOG41067B5 Histone deacetylase superfamily protein AL504_24470 ENOG41063Z6 transcriptional regulator, lysR family AL504_24475 ENOG4105DU1 integral membrane protein, terc AL504_24485 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AL504_24490 ENOG4105R1U AraC Family Transcriptional Regulator AL504_24495 ENOG4105DJ2 Major Facilitator Superfamily AL504_24505 ENOG4105D4Y metalloprotease AL504_24520 ENOG4105EPW hflc protein AL504_24525 ENOG4105CK1 PTS System AL504_24540 ENOG4108S3W Anti-feci sigma factor, fecr AL504_24545 ENOG4105CNM Receptor AL504_24550 ENOG4107GJV short-chain dehydrogenase reductase AL504_24565 ENOG4108S3W Anti-feci sigma factor, fecr AL504_24575 ENOG4108SF5 RNA Polymerase AL504_24580 ENOG4108S3W Anti-feci sigma factor, fecr AL504_24595 ENOG4107QM5 aconitate hydratase AL504_24610 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 AL504_24615 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AL504_24620 ENOG4108302 MgtC SapB transporter AL504_24625 ENOG4105F1J Homogentisate 1,2-dioxygenase AL504_24640 ENOG4105E6M Sulphatase-modifying factor protein AL504_24655 ENOG4105CF1 Alkylated DNA repair protein AL504_24665 ENOG4107RZC phospholipase d AL504_24670 ENOG4108JCI Transcriptional regulator AL504_24690 ENOG4105W8I Transcriptional regulator AL504_24695 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AL504_24710 ENOG4105DUM transcriptional regulator, lysR family AL504_24725 ENOG4108PCN EamA-like transporter family AL504_24730 ENOG4106AXJ AraC family transcriptional regulator AL504_24740 ENOG4105C6K Malic enzyme AL504_24760 ENOG4105CHB tonB-dependent Receptor AL504_24775 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) AL504_24780 ENOG4105CCU oxidase (Subunit III) AL504_24785 ENOG4105BZ9 Cytochrome C oxidase, subunit I AL504_24790 ENOG4105E2S oxidase) subunit II AL504_24795 ENOG4108UYB regulatoR AL504_24800 ENOG4105TX3 Histidine kinase AL504_24815 ENOG4108ZX6 Electron transport protein SCO1 SenC AL504_24835 ENOG4108K5P (LipO)protein AL504_24840 ENOG4105CDA abc transporter atp-binding protein AL504_24845 ENOG4105E5Q amino acid AbC transporter AL504_24850 ENOG4105EAB amino acid AbC transporter AL504_24855 ENOG4105KXX peptidase s58 dmpa AL504_24860 ENOG4108UT2 hemolysin iii AL504_24865 ENOG4105F7P transcriptional regulator AsnC family AL504_24875 ENOG4105C85 amino acid AL504_24880 ENOG4105CBN LysR family transcriptional regulator AL504_24905 ENOG4105D29 Helix-turn-helix type 11 domain protein AL504_24935 ENOG4108SF5 RNA Polymerase AL504_24940 ENOG4108S3W Anti-feci sigma factor, fecr AL504_24950 ENOG4106QJH hemin transport protein AL504_24955 ENOG4107R4I Periplasmic binding protein AL504_24960 ENOG4105EHG Permease protein AL504_24965 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AL504_24970 ENOG4108VPT UPF0234 protein AL504_24980 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AL504_24985 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AL504_24995 ENOG4108XG2 Histidine kinase AL504_25015 ENOG4105E0K tonB-dependent siderophore receptor AL504_25025 ENOG4108IV0 ABC, transporter AL504_25030 ENOG4105C0Z ABC transporter AL504_25040 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_25045 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein AL504_25080 ENOG41080E2 ribosomal-protein-alanine acetyltransferase AL504_25085 ENOG4105F04 LysR family Transcriptional regulator AL504_25090 ENOG4105C7F AcnD-accessory protein PrpF AL504_25110 ENOG4105CHR reductase AL504_25125 ENOG4105E3J oxidoreductase AL504_25140 ENOG4105XJC Two component transcriptional regulator (Winged helix family AL504_25145 ENOG4105IFJ Histidine kinase AL504_25155 ENOG41068KF Universal stress protein AL504_25160 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AL504_25165 ENOG4106NZI LysR family Transcriptional regulator AL504_25185 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AL504_25190 ENOG4105FCD Major Facilitator AL504_25200 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AL504_25205 ENOG4108IEG Formate dehydrogenase Alpha subunit AL504_25210 ENOG4107QIZ NADH dehydrogenase AL504_25225 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AL504_25230 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AL504_25235 ENOG4105CVM Molybdenum cofactor synthesis domain protein AL504_25240 ENOG4108RIR Molybdenum cofactor biosynthesis protein AL504_25245 ENOG4108ZAF Molybdopterin AL504_25255 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AL504_25265 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) AL504_25285 ENOG4108TZV Membrane AL504_25290 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AL504_25295 ENOG41086KC Transcriptional regulator AL504_25330 ENOG4107SET aldo keto reductase AL504_25335 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AL504_25340 ENOG4108JU5 Magnesium and cobalt efflux protein AL504_25345 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AL504_25350 ENOG4105C9A Phoh family AL504_25355 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AL504_25365 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AL504_25385 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL504_25390 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AL504_25395 ENOG4105VIE preprotein translocase, subunit YajC AL504_25410 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AL504_25415 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AL504_25440 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase AL504_25445 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AL504_25450 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AL504_25455 ENOG4105I5W Transporter AL504_25465 ENOG4105D7T ABC transporter AL504_25475 ENOG4105TNS Conserved Protein AL504_25490 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AL504_25495 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division AL504_25505 ENOG4105CHM Aminotransferase AL504_25515 ENOG4105C6K Malic enzyme AL504_25530 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AL504_25540 ENOG4105CV1 Transketolase (EC 2.2.1.1) AL504_25545 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AL504_25550 ENOG4105BZA Phosphoglycerate kinase AL504_25565 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AL504_25570 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AL504_25590 ENOG4108SHQ Glutathione S-transferase AL504_25600 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) AL504_25610 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) AL504_25625 ENOG4105CJ3 phosphate transporter AL504_25635 ENOG4108RIR Molybdenum cofactor biosynthesis protein AL504_25645 ENOG4105DR5 peptidase AL504_25655 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AL504_25665 ENOG4105MHT Transcriptional regulator, ARSR family AL504_25675 ENOG4105D5T phosphonate abc transporter AL504_25680 ENOG4105EHI Phosphonate ABC transporter, periplasmic AL504_25700 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL504_25705 ENOG410811B TRANSCRIPTIONal AL504_25710 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) AL504_25715 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) AL504_25720 ENOG4105FD8 phosphonate metabolism protein PhnM AL504_25725 ENOG4107RJJ Transcriptional regulator AL504_25730 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG AL504_25735 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH AL504_25745 ENOG4105FT8 Phosphonate metabolism AL504_25750 ENOG4105ENV phosphonate C-P lyase system protein PhnK AL504_25755 ENOG4105HRV phosphonate c-p lyase system protein phnl AL504_25760 ENOG4105FD8 phosphonate metabolism protein PhnM AL504_25775 ENOG4105CK2 sodium dicarboxylate symporter AL504_25795 ENOG4105C8V SAICAR synthetase AL504_25800 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) AL504_25805 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AL504_25810 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AL504_25815 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AL504_25820 ENOG4107HP6 Transcriptional regulator AL504_25825 ENOG4107QNJ CoA-transferase subunit B AL504_25840 ENOG4107QXX ABC transporter AL504_25845 ENOG41069M3 Transcriptional regulator AL504_25850 ENOG4105CYW agmatinase AL504_25855 ENOG4106TNF Periplasmic binding protein AL504_25860 ENOG4105E5Q amino acid AbC transporter AL504_25865 ENOG4105CDA abc transporter atp-binding protein AL504_25875 ENOG4108IV0 ABC, transporter AL504_25880 ENOG4105C0Z ABC transporter AL504_25885 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_25890 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_25915 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AL504_25935 ENOG4105DJG MaoC domain protein dehydratase AL504_25955 ENOG4105C1G acyl-Coa dehydrogenase AL504_25960 ENOG4105C7K acetolactate synthase AL504_25965 ENOG4105ETT transcriptional Regulator, LysR family AL504_25970 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AL504_25975 ENOG4108Z66 YbaK ebsC protein AL504_26010 ENOG4105CEY Amp-dependent synthetase and ligase AL504_26015 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AL504_26025 ENOG4108UKI Enoyl-CoA hydratase AL504_26030 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AL504_26045 ENOG4105EA8 2-Nitropropane dioxygenase AL504_26060 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AL504_26085 ENOG4107QMP dna polymerase iii subunits gamma and tau AL504_26095 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AL504_26100 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AL504_26105 ENOG4105D2X ABC transporter substrate-binding protein AL504_26115 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AL504_26130 ENOG4105ETX regulatoR AL504_26135 ENOG4105BZU Histidine kinase AL504_26145 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AL504_26150 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AL504_26155 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AL504_26165 ENOG4105EMU Dehydrogenase AL504_26170 ENOG4105CVJ phosphoglycerate mutase AL504_26190 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC AL504_26200 ENOG4105C2W permease AL504_26205 ENOG4105C8Q Methyl-accepting chemotaxis AL504_26210 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AL504_26215 ENOG4105HBR Rna-binding protein AL504_26220 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AL504_26225 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AL504_26235 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AL504_26245 ENOG4105C9X ppx gppa phosphatase AL504_26255 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) AL504_26260 ENOG4105C8U phosphate abc transporter AL504_26265 ENOG4105E2Z phosphate ABC transporter (Permease AL504_26270 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AL504_26275 ENOG4105D2S major facilitator superfamily AL504_26285 ENOG4105CSH Transporter AL504_26290 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AL504_26305 ENOG4105Z2P Protein of unknown function (DUF465) AL504_26320 ENOG4105K6V RNA polymerase AL504_26330 ENOG4105CC0 LysR family Transcriptional regulator AL504_26335 ENOG4105CF7 AraC family transcriptional regulator AL504_26340 ENOG4105CPC Aldo Keto reductase AL504_26370 ENOG4105FQ6 thiopurine methyltransferase AL504_26380 ENOG4107QIJ Aconitate hydratase 2 AL504_26400 ENOG41080XP Cbs domain AL504_26410 ENOG4105CTU Proline racemase AL504_26415 ENOG4105D38 putrescine abc transporter AL504_26420 ENOG4105F38 ABC transporter, permease AL504_26425 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AL504_26445 ENOG4107SDU Methyl-accepting chemotaxis AL504_26485 ENOG4105EGS Mechanosensitive ion channel AL504_26490 ENOG4105CMU LysR family (Transcriptional regulator AL504_26495 ENOG4105CYC Transferase AL504_26500 ENOG4105ETT transcriptional Regulator, LysR family AL504_26540 ENOG4105MP9 class II Aldolase AL504_26565 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) AL504_26575 ENOG4105C57 major facilitator superfamily AL504_26585 ENOG4105EUF amidase EC 3.5.1.4 AL504_26605 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AL504_26620 ENOG4105C8T Leucyl-tRNA synthetase AL504_26630 ENOG4108ZT1 Transcriptional regulator AL504_26640 ENOG4105DZ1 carboxypeptidase AL504_26660 ENOG4105C0Z ABC transporter AL504_26675 ENOG4105W0E 50S ribosomal protein L33 AL504_26680 ENOG4105KDC 50s ribosomal protein l28 AL504_26685 ENOG4105C2C drug resistance transporter, Bcr CflA AL504_26690 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AL504_26700 ENOG4108HQS Glycine betaine AL504_26705 ENOG4108IJ7 Glycine betaine AL504_26715 ENOG4105ETE Transcriptional regulator (LacI family AL504_26720 ENOG4105E9Z Nad-dependent epimerase dehydratase AL504_26725 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AL504_26730 ENOG4107RNG ABC transporter AL504_26740 ENOG4105DFW ABC transporter AL504_26745 ENOG4105TW1 Carbohydrate-selective porin OprB AL504_26750 ENOG4105CHU acetyl-coa acetyltransferase AL504_26760 ENOG4105DRR Transcriptional regulator, GntR family AL504_26770 ENOG4105E39 Enoyl-CoA hydratase AL504_26775 ENOG4105CEY Amp-dependent synthetase and ligase AL504_26785 ENOG4105CPC Aldo Keto reductase AL504_26795 ENOG4105C7J ABC transporter, permease AL504_26810 ENOG4105MWK D-amino acid dehydrogenase, small subunit AL504_26840 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AL504_26845 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AL504_26850 ENOG4105E0C molybdate abc transporter AL504_26855 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AL504_26860 ENOG4105F4R Transcriptional regulator mode AL504_26880 ENOG4105C1P efflux transporter, rnd family, mfp subunit AL504_26885 ENOG4105BZS acriflavin resistance protein AL504_26890 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AL504_26895 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AL504_26900 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AL504_26905 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AL504_26910 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AL504_26915 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AL504_26925 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AL504_26930 ENOG4105EJC lysr family transcriptional regulator AL504_26935 ENOG4105CA0 peroxidase AL504_26940 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AL504_26960 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AL504_26965 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AL504_26970 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AL504_26975 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AL504_26990 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AL504_27010 ENOG4105C58 cytochrome c oxidase accessory protein ccog AL504_27030 ENOG4105C26 Dehydrogenase AL504_27035 ENOG4105CDA abc transporter atp-binding protein AL504_27040 ENOG4105EAB amino acid AbC transporter AL504_27050 ENOG4105DRP amino acid AbC transporter AL504_27055 ENOG4105CJP fad dependent oxidoreductase AL504_27090 ENOG4105RHY Pfam:UPF0157 AL504_27100 ENOG4105CPK Glycosyl transferase (Group 1 AL504_27115 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AL504_27120 ENOG4105Y49 secretion protein, HlyD family AL504_27140 ENOG4107SQD Transcriptional regulator, GntR family AL504_27145 ENOG4108KF1 Membrane AL504_27150 ENOG4108Z9W Outer membrane porin AL504_27165 ENOG4108JQ7 (ABC) transporter AL504_27170 ENOG4105C3U ABC transporter AL504_27175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL504_27185 ENOG4105RQF LysR family Transcriptional regulator AL504_27190 ENOG4107FW0 short-chain dehydrogenase reductase AL504_27195 ENOG4108ZHJ Organic hydroperoxide resistance protein AL504_27200 ENOG4105E0F Histidine kinase AL504_27205 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AL504_27225 ENOG4105C0H protease AL504_27230 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AL504_27240 ENOG4107XBN GntR Family Transcriptional Regulator AL504_27255 ENOG4108SF5 RNA Polymerase AL504_27275 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AL504_27285 ENOG4106HBX Transcriptional Regulator AraC Family AL504_27295 ENOG4105DZQ phospholipase D Transphosphatidylase AL504_27335 ENOG4105N14 lysine exporter protein LysE YggA AL504_27340 ENOG4105F7P transcriptional regulator AsnC family AL504_27360 ENOG4108NIW Leucine export protein LeuE AL504_27365 ENOG4105I03 Flagellin AL504_27370 ENOG4108PYU two-component system response regulator AL504_27385 ENOG4105E0K tonB-dependent siderophore receptor AL504_27390 ENOG4108S3W Anti-feci sigma factor, fecr AL504_27395 ENOG4108SF5 RNA Polymerase AL504_27400 ENOG4105C8Q Methyl-accepting chemotaxis AL504_27405 ENOG4108TTM chaperone AL504_27415 ENOG4106EAR Fimbrial protein AL504_27425 ENOG4105XJC Two component transcriptional regulator (Winged helix family AL504_27430 ENOG4105DHQ Histidine kinase AL504_27435 ENOG4105GTN ParB Domain Protein Nuclease AL504_27440 ENOG4105BZV Phosphoadenosine phosphosulfate reductase AL504_27445 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) AL504_27450 ENOG4108Z7R Chaperone CsaA AL504_27505 ENOG4105CGZ zinc metallopeptidase AL504_27510 ENOG4107RTD sua5 ycio yrdc ywlc family protein AL504_27515 ENOG4108Z4T Peptidase M50 AL504_27520 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AL504_27525 ENOG4105GJM (LipO)protein AL504_27535 ENOG4105EZE Cupin 4 family protein AL504_27540 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AL504_27575 ENOG4105NAE bifunctional deaminase-reductase domain protein AL504_27585 ENOG4106KR7 LysR family Transcriptional regulator AL504_27630 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AL504_27635 ENOG4105CC0 LysR family Transcriptional regulator AL504_27645 ENOG4105WKW Pfam:DUF1458 AL504_27680 ENOG4108IY8 ABC, transporter AL504_27690 ENOG4105GVF (ABC) transporter AL504_27730 ENOG4105D64 Mechanosensitive ion channel AL504_27750 ENOG4105EJC lysr family transcriptional regulator AL504_27770 ENOG4105ECY inositol monophosphatase AL504_27775 ENOG4105DFS Conserved Protein AL504_27780 ENOG4105CJ2 (LipO)protein AL504_27790 ENOG4108T0W nitrous oxide maturation protein NosY AL504_27795 ENOG4105CIG ABC transporter AL504_27805 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) AL504_27810 ENOG4105HEE Binding Domain protein AL504_27820 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AL504_27835 ENOG4105EE5 Membrane protein terC AL504_27840 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AL504_27845 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) AL504_27860 ENOG4105C8N cysteinyl-tRNA synthetase AL504_27870 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AL504_27875 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AL504_27880 ENOG4105CFH Aspartokinase AL504_27895 ENOG4105C58 cytochrome c oxidase accessory protein ccog AL504_27915 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AL504_27930 ENOG4105NQN cytochrome C AL504_27935 ENOG41090Y2 cytochrome C AL504_27940 ENOG4105BZU Histidine kinase AL504_27945 ENOG4105BZU Histidine kinase AL504_27950 ENOG4105BZU Histidine kinase AL504_27955 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) AL504_27965 ENOG4108RZE Tetr family transcriptional regulator AL504_27970 ENOG4105D5T phosphonate abc transporter AL504_28010 ENOG4105HEI LysR family (Transcriptional regulator AL504_28035 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AL504_28040 ENOG4108T2C cysteine dioxygenase type I AL504_28045 ENOG4105J4Q Transcriptional regulator AL504_28055 ENOG4105CGU Enoyl-CoA hydratase AL504_28085 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) AL504_28090 ENOG4105BZ1 (ABC) transporter AL504_28110 ENOG4105CEY Amp-dependent synthetase and ligase AL504_28125 ENOG4105CHU acetyl-coa acetyltransferase AL504_28140 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL504_28150 ENOG4107QPN acyl-Coa dehydrogenase AL504_28155 ENOG4108XG4 DNA-binding transcriptional regulator AL504_28165 ENOG4105WH1 Two component transcriptional regulator luxr family AL504_28170 ENOG4105WH1 Two component transcriptional regulator luxr family AL504_28175 ENOG4106CD9 glycosyl transferase group 1 AL504_28180 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF AL504_28185 ENOG4106WTF Glycosyl transferase, family 2 AL504_28190 ENOG4107T8Q Glycosyl transferase (Group 1 AL504_28210 ENOG4105C30 Nad-dependent epimerase dehydratase AL504_28225 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AL504_28230 ENOG4105FGF GDP-mannose mannosyl hydrolase AL504_28235 ENOG4105D3Q Sugar transferase AL504_28255 ENOG4107QP8 phosphohexose isomerase AL504_28260 ENOG4105CMR udp-glucose 4-epimerase AL504_28265 ENOG4105D7W serine acetyltransferase AL504_28270 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AL504_28275 ENOG4105ECY inositol monophosphatase AL504_28280 ENOG4105C26 Dehydrogenase AL504_28285 ENOG4108JPW Aminotransferase AL504_28305 ENOG4105D7N magnesium and cobalt transport protein CorA AL504_28325 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL504_28330 ENOG4108JQ6 ABC transporter AL504_28335 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) AL504_28355 ENOG4105BZU Histidine kinase AL504_28425 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AL504_28440 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AL504_28455 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AL504_28460 ENOG4105EJC lysr family transcriptional regulator AL504_28470 ENOG4105C0R drug resistance transporter emrb qaca subfamily AL504_28475 ENOG4105CW7 secretion protein, HlyD family AL504_28490 ENOG4105UYK outer membrane protein a AL504_28495 ENOG4107QM5 aconitate hydratase AL504_28500 ENOG4105JQN Transcriptional regulator AL504_28515 ENOG4105CHR reductase AL504_28525 ENOG4108IV0 ABC, transporter AL504_28530 ENOG4105C0Z ABC transporter AL504_28535 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_28545 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AL504_28550 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) AL504_28555 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme AL504_28560 ENOG4105DCT glycerol dehydrogenase AL504_28565 ENOG4108WYP Transcriptional regulator AL504_28570 ENOG4108HHA Transketolase AL504_28575 ENOG4108IUS Transketolase AL504_28580 ENOG4105E2X shikimate dehydrogenase AL504_28590 ENOG4105DIA mandelate racemase muconate lactonizing AL504_28595 ENOG4105EAB amino acid AbC transporter AL504_28605 ENOG4105DRP amino acid AbC transporter AL504_28615 ENOG4105CTX dehydratase AL504_28625 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AL504_28630 ENOG4105ERH Fumarylacetoacetate hydrolase AL504_28635 ENOG4105J4Q Transcriptional regulator AL504_28665 ENOG4108UAJ Transcriptional regulator AL504_28685 ENOG4105EHG Permease protein AL504_28690 ENOG4108W0P ABC transporter AL504_28705 ENOG4105D05 Receptor AL504_28730 ENOG4105EUR Domain-Containing protein AL504_28755 ENOG4105BZU Histidine kinase AL504_28760 ENOG4105CSH Transporter AL504_28780 ENOG4107S4Y M20 DapE family protein YgeY AL504_28790 ENOG4105FDF Could be involved in DNA repair (By similarity) AL504_28795 ENOG4105DQE DNA ligase AL504_28800 ENOG4105C85 amino acid AL504_28810 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) AL504_28815 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AL504_28825 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AL504_28830 ENOG4105CG3 alpha amylase, catalytic region AL504_28835 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) AL504_28840 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AL504_28845 ENOG4107UXM Membrane AL504_28850 ENOG4105DZQ phospholipase D Transphosphatidylase AL504_28855 ENOG4105X23 Endonuclease Exonuclease phosphatase AL504_28875 ENOG4108Z9Z response to DNA damage stimulus AL504_28885 ENOG4107QP8 phosphohexose isomerase AL504_28895 ENOG4105D64 Mechanosensitive ion channel AL504_28965 ENOG4105DQ4 alcohol dehydrogenase AL504_28980 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate AL504_28990 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL504_28995 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AL504_29000 ENOG4105ETE Transcriptional regulator (LacI family AL504_29010 ENOG4105C26 Dehydrogenase AL504_29015 ENOG4105CIR epoxide hydrolase AL504_29040 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AL504_29065 ENOG4108S8N class II Aldolase AL504_29125 ENOG4105E02 MotA TolQ exbB proton channel AL504_29130 ENOG4105SG9 biopolymer transport protein, ExbD AL504_29170 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) AL504_29175 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) AL504_29180 ENOG4105D7T ABC transporter AL504_29195 ENOG4105WH1 Two component transcriptional regulator luxr family AL504_29200 ENOG4105BZU Histidine kinase AL504_29205 ENOG4105DA5 (ABC) transporter AL504_29210 ENOG4105E3A (ABC) transporter AL504_29225 ENOG4105CHU acetyl-coa acetyltransferase AL504_29235 ENOG4108ZXC Two component transcriptional regulator, luxr family AL504_29240 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AL504_29255 ENOG4105CEY Amp-dependent synthetase and ligase AL504_29270 ENOG4108JA1 polyketide synthase AL504_29285 ENOG4105DVW rieske (2Fe-2S) AL504_29310 ENOG4105CN2 monooxygenase, FAD-binding AL504_29315 ENOG4108UT2 hemolysin iii AL504_29365 ENOG4105RQF LysR family Transcriptional regulator AL504_29370 ENOG410633P Hydantoin racemase AL504_29375 ENOG4108JQ6 ABC transporter AL504_29380 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AL504_29385 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AL504_29390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL504_29410 ENOG4105C0R drug resistance transporter emrb qaca subfamily AL504_29415 ENOG4105CBN LysR family transcriptional regulator AL504_29495 ENOG4105HBA AroM protein AL504_29510 ENOG4105EZR dyp-type peroxidase family protein AL504_29535 ENOG4105JAB phenazine biosynthesis protein, phzf family AL504_29545 ENOG4105CC0 LysR family Transcriptional regulator AL504_29550 ENOG4105F27 Major Facilitator AL504_29555 ENOG4105ETT transcriptional Regulator, LysR family AL504_29570 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AL504_29585 ENOG4105DNH Major Facilitator AL504_29595 ENOG4105D01 (LipO)protein AL504_29600 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AL504_29605 ENOG4108UMI ABC transporter, permease AL504_29625 ENOG4105CSR polyphosphate kinase 2 AL504_29630 ENOG4105VEJ Heat shock protein AL504_29635 ENOG4105BZU Histidine kinase AL504_29660 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) AL504_29665 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AL504_29680 ENOG4105CH2 amidohydrolase AL504_29700 ENOG4105EBR Carboxylesterase AL504_29705 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AL504_29710 ENOG4105DDW LysR family Transcriptional regulator AL504_29725 ENOG4105CVE Lytic murein transglycosylase AL504_29735 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AL504_29740 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AL504_29750 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AL504_29775 ENOG4108XM1 transcriptional regulator AsnC family AL504_29790 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria AL504_29825 ENOG4108TGY Glutathione S-transferase AL504_29840 ENOG4105VRT cytoplasmic protein AL504_29850 ENOG4105DXI Major Facilitator superfamily AL504_29860 ENOG4105WPR Transcriptional regulator, ARAC family AL504_29865 ENOG4105CNM Receptor AL504_29870 ENOG4105CNM Receptor AL504_29885 ENOG4105R8A Heat shock protein AL504_29890 ENOG410642W LysR family Transcriptional regulator AL504_29895 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AL504_29915 ENOG4105CSH Transporter AL504_29925 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AL504_29935 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AL504_29960 ENOG4105EQN UPF0261 protein AL504_29985 ENOG4105JN3 extra-cytoplasmic solute receptor family protein AL504_29995 ENOG4108ARY Protein CrcB homolog AL504_30015 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AL504_30020 ENOG4105CHR reductase AL504_30045 ENOG4105C26 Dehydrogenase AL504_30050 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase AL504_30065 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AL504_30080 ENOG4105C5I Dehydrogenase AL504_30100 ENOG4107YCY Transcriptional regulator AL504_30105 ENOG4105DG4 malate L-lactate dehydrogenase AL504_30115 ENOG4105CNV Aldolase AL504_30120 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AL504_30125 ENOG4105RQF LysR family Transcriptional regulator AL504_30130 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) AL504_30140 ENOG4105CJR Integral membrane protein (MviN AL504_30150 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AL504_30155 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AL504_30160 ENOG4105W49 UPF0434 protein AL504_30165 ENOG4105DQY intracellular growth attenuator AL504_30170 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AL504_30185 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AL504_30195 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AL504_30200 ENOG4105C8Q Methyl-accepting chemotaxis AL504_30205 ENOG4105CMQ Chloride channel AL504_30210 ENOG4105CHU acetyl-coa acetyltransferase AL504_30220 ENOG4105VEQ Cold shock protein AL504_30225 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AL504_30230 ENOG4105DN3 alpha-2-macroglobulin domain protein AL504_30235 ENOG4108JQB penicillin-binding protein 1C AL504_30245 ENOG4105F1S paraquat-inducible protein a AL504_30250 ENOG4105DY2 Paraquat-inducible protein b AL504_30260 ENOG4105C26 Dehydrogenase AL504_30270 ENOG4105C32 Amino acid ABC transporter (Permease) AL504_30275 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AL504_30280 ENOG4105C0Z ABC transporter AL504_30285 ENOG4108IV0 ABC, transporter AL504_30305 ENOG4105DCM major facilitator superfamily AL504_30325 ENOG4105DSW Fusaric acid resistance protein AL504_30335 ENOG4105Y49 secretion protein, HlyD family AL504_30350 ENOG4105CYM Glutathione S-transferase AL504_30360 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AL504_30365 ENOG4108Z9K Osmotically inducible protein AL504_30370 ENOG4105CIF Ornithine Cyclodeaminase AL504_30400 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AL504_30445 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AL504_30450 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AL504_30455 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AL504_30460 ENOG4105DTN riboflavin biosynthesis protein ribF AL504_30465 ENOG4108V3E phosphoribosylglycinamide formyltransferase AL504_30485 ENOG4105C4R Atp-dependent dna helicase AL504_30500 ENOG4105PE1 Receptor AL504_30505 ENOG4105PE1 Receptor AL504_30510 ENOG4105PE1 Receptor AL504_30525 ENOG4105C5H ABC transporter AL504_30530 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AL504_30540 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) AL504_30695 ENOG4105UZW Tail fiber assembly protein AL504_30710 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AL504_30860 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AL504_30875 ENOG4105DS1 cytochrome b561 AL504_30880 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AL504_30905 ENOG4108IG5 Transcriptional regulator AL504_30930 ENOG4105EJC lysr family transcriptional regulator AL504_30940 ENOG4105KME endoribonuclease L-psp AL504_30965 ENOG4105VEQ Cold shock protein AL504_30975 ENOG4105VEQ Cold shock protein AL504_30980 ENOG4108TEB UPF0114 protein AL504_30985 ENOG4108K0D peptidase, M48 AL504_30990 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AL504_30995 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AL504_31000 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AL504_31005 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AL504_31010 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AL504_31015 ENOG4105CGF Aromatic amino acid aminotransferase AL504_31020 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AL504_31030 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AL504_31035 ENOG4105C3J Cysteine desulfurase AL504_31040 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AL504_31045 ENOG4108Z4V iron-sulfur cluster assembly AL504_31050 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) AL504_31055 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AL504_31060 ENOG4108ZIT Ferredoxin, 2FE-2S AL504_31065 ENOG4105WVQ Fe-S assembly protein IscX AL504_31070 ENOG4108Z5K methylglyoxal synthase AL504_31080 ENOG4105CGU Enoyl-CoA hydratase AL504_31085 ENOG4105C0Z ABC transporter AL504_31105 ENOG4108IV0 ABC, transporter AL504_31110 ENOG4108IQE Amp-dependent synthetase and ligase AL504_31120 ENOG4108RZE Tetr family transcriptional regulator AL504_31145 ENOG4105DFA alanine racemase domain protein AL504_31150 ENOG4105DKK Benzoate AL504_31165 ENOG4105CRK lysyL-tRNA synthetase AL504_31170 ENOG410904N short-chain dehydrogenase reductase AL504_31180 ENOG4105CSP Major Facilitator Superfamily AL504_31190 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AL504_31200 ENOG4108RG0 uracil-dna glycosylase AL504_31245 ENOG4105CS6 Rhs element vgr protein AL504_31305 ENOG4105C8Q Methyl-accepting chemotaxis AL504_31320 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AL504_31370 ENOG4105F27 Major Facilitator AL504_31380 ENOG4107QX9 Thiol disulfide interChange protein AL504_31445 ENOG4108RB4 3-methyladenine DNA glycosylase AL504_31465 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AL504_31485 ENOG4105ED9 Protein of unknown function (DUF455) AL504_31515 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AL504_31520 ENOG4107ZYJ bioY protein AL504_31535 ENOG4105K8N protein family UPF0079, ATPase AL504_31590 ENOG4108NST exported protein AL504_31660 ENOG4105C4R Atp-dependent dna helicase AL504_31670 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AL504_31730 ENOG4105VUH addiction module killer protein AL504_31770 ENOG41061WM D-Alanyl-D-Alanine AL504_31800 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AL504_31820 ENOG4108R4U Hnh endonuclease AL504_31825 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AL504_31835 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)