locus-tag class description FOC83_00030 ENOG4108KXH Ybak prolyl-tRNA synthetase associated FOC83_00045 ENOG4107QWP ABC-2 type transporter FOC83_00050 ENOG4105CJ1 ABC, transporter FOC83_00060 ENOG410630P Transcriptional regulator FOC83_00065 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FOC83_00075 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC83_00085 ENOG4105E98 transcriptional regulator DeoR family FOC83_00090 ENOG4108IJ9 (ABC) transporter FOC83_00095 ENOG4108IJ9 (ABC) transporter FOC83_00150 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC83_00155 ENOG4108Z9W Outer membrane porin FOC83_00175 ENOG4108JU3 Alkyl hydroperoxide reductase FOC83_00180 ENOG41062ES Transcriptional regulator FOC83_00185 ENOG4105C1G acyl-Coa dehydrogenase FOC83_00215 ENOG4105EW9 transcriptional regulator AsnC family FOC83_00220 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC83_00225 ENOG4107RH8 nuclease SbcCD subunit D FOC83_00255 ENOG4105D65 subunit l FOC83_00260 ENOG4108ZE9 Monovalent cation H antiporter subunit C FOC83_00265 ENOG4107R4Z monovalent cation h antiporter subunit d FOC83_00270 ENOG4105SC1 monovalent cation H antiporter subunit E FOC83_00275 ENOG4105W4C monovalent cation H antiporter subunit F FOC83_00280 ENOG4105KJM monovalent cation h antiporter subunit g FOC83_00290 ENOG4106TCE FOC83_00295 ENOG4108Z6B deaminase FOC83_00300 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC83_00305 ENOG4105C5H ABC transporter FOC83_00340 ENOG41080RH Thioredoxin FOC83_00345 ENOG4105DEN Luciferase family FOC83_00355 ENOG4105C7N Xanthine uracil vitamin C permease FOC83_00360 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC83_00365 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC83_00380 ENOG4108K5P (LipO)protein FOC83_00400 ENOG4106NZI LysR family Transcriptional regulator FOC83_00405 ENOG4105F27 Major Facilitator FOC83_00410 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC83_00430 ENOG4105EHV domain protein FOC83_00440 ENOG4105D6S protein involved in catabolism of external DNA FOC83_00445 ENOG4107T6V glycerophosphoryl diester phosphodiesterase FOC83_00455 ENOG4105EIN peptidylprolyl cis-trans isomerase FOC83_00460 ENOG4108UJV acyl-CoA thioesterase i FOC83_00465 ENOG4108I0Y (ABC) transporter FOC83_00475 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component FOC83_00480 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_00485 ENOG4105ETT transcriptional Regulator, LysR family FOC83_00490 ENOG4105EAC phosphoserine phosphatase FOC83_00505 ENOG4105DND Transcriptional regulator FOC83_00520 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC83_00535 ENOG4105DND Transcriptional regulator FOC83_00540 ENOG4105CFM UPF0317 protein FOC83_00550 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_00560 ENOG4105C0Z ABC transporter FOC83_00565 ENOG4108IV0 ABC, transporter FOC83_00570 ENOG4108Z9W Outer membrane porin FOC83_00575 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC83_00590 ENOG4105E09 nadh pyrophosphatase FOC83_00630 ENOG4107R0W ABC transporter FOC83_00635 ENOG4105E5Q amino acid AbC transporter FOC83_00640 ENOG4105CDA abc transporter atp-binding protein FOC83_00645 ENOG4105D3W isochorismatase FOC83_00650 ENOG4105ECQ AraC Family Transcriptional Regulator FOC83_00655 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC83_00660 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FOC83_00665 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FOC83_00680 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC83_00690 ENOG4105D5K Hemolysin activator protein FOC83_00695 ENOG4105CKT filamentous hemagglutinin FOC83_00700 ENOG4105K4H Nlp p60 protein FOC83_00705 ENOG4105UGU tonB-dependent Receptor FOC83_00715 ENOG4105FYV Amp nucleosidase FOC83_00720 ENOG4108IQI permease FOC83_00725 ENOG4105DSJ YicC domain protein FOC83_00730 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FOC83_00740 ENOG4105C1G acyl-Coa dehydrogenase FOC83_00750 ENOG4105BZU Histidine kinase FOC83_00755 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC83_00760 ENOG4105CSA Coproporphyrinogen iii oxidase FOC83_00770 ENOG4105CUX Signal transduction histidine kinase FOC83_00775 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC83_00780 ENOG4105EQ1 Transcriptional regulator FOC83_00790 ENOG4105EUB pirin domain protein FOC83_00795 ENOG4108S2Y peptide Chain Release factor FOC83_00810 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_00815 ENOG4105E0C molybdate abc transporter FOC83_00825 ENOG4105DP0 ferredoxin-NADP reductase FOC83_00845 ENOG4105DND Transcriptional regulator FOC83_00850 ENOG4105KME endoribonuclease L-psp FOC83_00855 ENOG4105CB5 ATP-dependent DNA helicase recG FOC83_00875 ENOG4106EYY FOC83_00880 ENOG4107TAE Glycosyl transferase (Group 1 FOC83_00905 ENOG4106PQC FOC83_00910 ENOG4105DBA pectate lyase FOC83_00920 ENOG4105CP9 extracellular ligand-binding receptor FOC83_00925 ENOG4107EXC regulatoR FOC83_00930 ENOG4105JJR Histidine kinase FOC83_00945 ENOG4108IJ9 (ABC) transporter FOC83_00955 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FOC83_00960 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC83_00965 ENOG4105II7 pyrroline-5-carboxylate reductase FOC83_00970 ENOG4105EX9 Membrane FOC83_00980 ENOG4105CP9 extracellular ligand-binding receptor FOC83_00985 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_00990 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC83_00995 ENOG4105C0Z ABC transporter FOC83_01000 ENOG4108IV0 ABC, transporter FOC83_01025 ENOG4105RQF LysR family Transcriptional regulator FOC83_01030 ENOG4108K3A Glutathione S-transferase FOC83_01035 ENOG4105D8V Glucose sorbosone dehydrogenase FOC83_01045 ENOG4105DJP Membrane FOC83_01070 ENOG4105CYW agmatinase FOC83_01080 ENOG4105D01 (LipO)protein FOC83_01090 ENOG4105F27 Major Facilitator FOC83_01100 ENOG4107RN3 metallophosphoesterase FOC83_01110 ENOG4105DJ4 phosphatidylserine decarboxylase FOC83_01115 ENOG4105C5H ABC transporter FOC83_01140 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC83_01145 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FOC83_01150 ENOG4105BZU Histidine kinase FOC83_01165 ENOG4105D94 Major Facilitator Superfamily FOC83_01170 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) FOC83_01190 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC83_01195 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC83_01200 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC83_01250 ENOG4107R7Y intracellular protease Pfpi family FOC83_01270 ENOG4105C5I Dehydrogenase FOC83_01285 ENOG4105BZU Histidine kinase FOC83_01300 ENOG4105E0K tonB-dependent siderophore receptor FOC83_01320 ENOG4106RE7 Cytochrome FOC83_01335 ENOG4105EE5 Membrane protein terC FOC83_01345 ENOG4105JJR Histidine kinase FOC83_01390 ENOG4108VAU general secretion pathway protein G FOC83_01415 ENOG4107QHF type ii secretion system protein e FOC83_01420 ENOG4105D7Q type ii secretion system FOC83_01475 ENOG4105X5Z General secretion pathway protein I FOC83_01515 ENOG4105BZU Histidine kinase FOC83_01520 ENOG4108Z4X TRANSCRIPTIONal FOC83_01530 ENOG4105BZU Histidine kinase FOC83_01560 ENOG4108IY8 ABC, transporter FOC83_01565 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC83_01570 ENOG4106FTQ Taurine ABC transporter, periplasmic FOC83_01595 ENOG4105CN1 protease FOC83_01615 ENOG4105IPI Membrane FOC83_01625 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC83_01640 ENOG4107R7I amino acid FOC83_01685 ENOG4105KME endoribonuclease L-psp FOC83_01690 ENOG4105FC8 fad dependent oxidoreductase FOC83_01705 ENOG4105ERH Fumarylacetoacetate hydrolase FOC83_01735 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase FOC83_01775 ENOG4108K3A Glutathione S-transferase FOC83_01780 ENOG4105DUM transcriptional regulator, lysR family FOC83_01790 ENOG4105CSH Transporter FOC83_01800 ENOG4105DWT malate dehydrogenase (quinone) FOC83_01830 ENOG4105CAU Arsenical resistance protein, ArsH FOC83_01840 ENOG4105D6J arsenicaL-resistance protein FOC83_01850 ENOG41085FC arsR family transcriptional regulator FOC83_01860 ENOG4105DZ0 fad dependent oxidoreductase FOC83_01880 ENOG4105CDA abc transporter atp-binding protein FOC83_01885 ENOG4105DRP amino acid AbC transporter FOC83_01890 ENOG4105EZ7 amino acid ABC transporter FOC83_01895 ENOG4107QXX ABC transporter FOC83_01900 ENOG4105C28 cystathionine FOC83_01905 ENOG4105RQF LysR family Transcriptional regulator FOC83_01925 ENOG4105C3U ABC transporter FOC83_01935 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC83_01940 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC83_01950 ENOG4105RQF LysR family Transcriptional regulator FOC83_01955 ENOG4105CHJ isochorismatase hydrolase FOC83_01960 ENOG41088CQ domain protein FOC83_01970 ENOG4105H1G trap transporter solute receptor taxi family FOC83_01975 ENOG4105DG7 nitrate ABC transporter FOC83_01980 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC83_01985 ENOG4105D7T ABC transporter FOC83_01995 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC83_02005 ENOG4108PG2 copper resistance FOC83_02035 ENOG4105CTX dehydratase FOC83_02050 ENOG4105ECM Sensor protein basS pmrB FOC83_02055 ENOG4105ETX regulatoR FOC83_02065 ENOG4105EHG Permease protein FOC83_02070 ENOG41090JD Blue (Type 1) copper domain protein FOC83_02075 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_02080 ENOG4105C7B Threonine dehydratase FOC83_02085 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC83_02090 ENOG4105E9K Isocitrate dehydrogenase FOC83_02095 ENOG4105DQR SNARE associated Golgi FOC83_02105 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC83_02110 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) FOC83_02145 ENOG4105CNM Receptor FOC83_02155 ENOG4105DQ5 transport system permease protein FOC83_02160 ENOG4105TVJ transport system, permease FOC83_02165 ENOG4105E0A ABC, transporter FOC83_02170 ENOG4105CDA abc transporter atp-binding protein FOC83_02175 ENOG4105E5Q amino acid AbC transporter FOC83_02180 ENOG4105EAB amino acid AbC transporter FOC83_02185 ENOG4105EA8 2-Nitropropane dioxygenase FOC83_02190 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC83_02200 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC83_02210 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_02225 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FOC83_02230 ENOG4108KXM LysR family Transcriptional regulator FOC83_02235 ENOG4105CMQ Chloride channel FOC83_02240 ENOG41067TZ transcriptional regulator, MarR family FOC83_02250 ENOG4105BZU Histidine kinase FOC83_02255 ENOG4108ZXC Two component transcriptional regulator, luxr family FOC83_02285 ENOG4107R11 Transcriptional regulator FOC83_02305 ENOG4105CDA abc transporter atp-binding protein FOC83_02315 ENOG4105E5Q amino acid AbC transporter FOC83_02370 ENOG4108UQ8 endoribonuclease L-psp FOC83_02405 ENOG4108KB2 LysR family Transcriptional regulator FOC83_02410 ENOG4105DTQ mandelate racemase muconate lactonizing FOC83_02420 ENOG4105DRR Transcriptional regulator, GntR family FOC83_02425 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC83_02440 ENOG4105JSC dimethylmenaquinone methyltransferase FOC83_02465 ENOG4105DG7 nitrate ABC transporter FOC83_02470 ENOG4105I5W Transporter FOC83_02490 ENOG41063TF transcriptional regulator (AraC FOC83_02515 ENOG4105EZ7 amino acid ABC transporter FOC83_02535 ENOG4105WH1 Two component transcriptional regulator luxr family FOC83_02540 ENOG4105BZU Histidine kinase FOC83_02545 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FOC83_02550 ENOG4107B2H carbonic anhydrase FOC83_02555 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC83_02560 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FOC83_02565 ENOG41076YT nitrate reductase, gamma subunit FOC83_02570 ENOG4105R3A Nitrate reductase FOC83_02575 ENOG4108IUE nitrate reductase beta subunit FOC83_02580 ENOG4105CRU nitrate reductase, alpha subunit FOC83_02585 ENOG4105DQQ Major facilitator superfamily MFS_1 FOC83_02610 ENOG4105EXG Transcriptional regulator FOC83_02620 ENOG4105BZS acriflavin resistance protein FOC83_02625 ENOG4105BZS acriflavin resistance protein FOC83_02630 ENOG4105EMY transcriptional regulator FOC83_02670 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC83_02690 ENOG4105EA8 2-Nitropropane dioxygenase FOC83_02705 ENOG4105BZU Histidine kinase FOC83_02710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC83_02715 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) FOC83_02720 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FOC83_02730 ENOG4105E0X reductase FOC83_02735 ENOG4107U7B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC83_02780 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC83_02785 ENOG4105T38 integral membrane protein FOC83_02790 ENOG4105VCD cytoplasmic protein FOC83_02795 ENOG4105D22 carbon starvation protein FOC83_02810 ENOG4105EUJ GTP cyclohydrolase i FOC83_02820 ENOG4107NQ8 LysR family Transcriptional regulator FOC83_02825 ENOG4106FTQ Taurine ABC transporter, periplasmic FOC83_02835 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC83_02850 ENOG4108S3W Anti-feci sigma factor, fecr FOC83_02855 ENOG4108SF5 RNA Polymerase FOC83_02860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC83_02865 ENOG4105I1J Autotransporter FOC83_02865 ENOG4105I1J Autotransporter FOC83_02875 ENOG4108S8N class II Aldolase FOC83_02880 ENOG4105CJP fad dependent oxidoreductase FOC83_02890 ENOG4105CKI cobalamin synthesis protein FOC83_02895 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC83_02900 ENOG4108JQ6 ABC transporter FOC83_02905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC83_02915 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC83_02930 ENOG4108FUF Transcriptional regulator, IclR family FOC83_02935 ENOG4105C1J atp-dependent rna helicase FOC83_02940 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC83_02955 ENOG4105DSW Fusaric acid resistance protein FOC83_02960 ENOG4105ZQC membrane protein AaeX FOC83_02965 ENOG4105Y49 secretion protein, HlyD family FOC83_02980 ENOG4105C7K acetolactate synthase FOC83_02990 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FOC83_03000 ENOG4106KED esterase YpfH FOC83_03005 ENOG4108IQI permease FOC83_03010 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_03025 ENOG4105C0B DNA polymerase III (alpha subunit) FOC83_03040 ENOG4105EQ2 LysR family Transcriptional regulator FOC83_03045 ENOG4107S5I aldo keto reductase FOC83_03055 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC83_03065 ENOG4105CHR reductase FOC83_03070 ENOG4107V2S Transcriptional regulator FOC83_03110 ENOG4108VKM cytochrome b561 FOC83_03135 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_03170 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FOC83_03185 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein FOC83_03190 ENOG4108IUZ ABC transporter FOC83_03195 ENOG4105C0Z ABC transporter FOC83_03200 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_03215 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC83_03235 ENOG4105E0K tonB-dependent siderophore receptor FOC83_03250 ENOG4108FUF Transcriptional regulator, IclR family FOC83_03260 ENOG4105CSH Transporter FOC83_03265 ENOG4105CPC Aldo Keto reductase FOC83_03280 ENOG4105PF9 Transcriptional regulator FOC83_03300 ENOG4105EWC Purine nucleoside phosphorylase FOC83_03310 ENOG4105R1U AraC Family Transcriptional Regulator FOC83_03325 ENOG4107R0U MotA TolQ exbB proton channel FOC83_03345 ENOG4105GRZ Ycii-related protein FOC83_03350 ENOG4105GRZ Ycii-related protein FOC83_03360 ENOG4105CHP RNA polymerase FOC83_03370 ENOG4105DXC membrane FOC83_03380 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FOC83_03390 ENOG4105DUM transcriptional regulator, lysR family FOC83_03410 ENOG4108K3A Glutathione S-transferase FOC83_03420 ENOG41082F9 transcriptional regulator FOC83_03425 ENOG410756H nucleotidyltransferase FOC83_03445 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC83_03500 ENOG4105ER2 Ompa motb domain protein FOC83_03540 ENOG4105CS6 Rhs element vgr protein FOC83_03545 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC83_03600 ENOG4105CS6 Rhs element vgr protein FOC83_03680 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC83_03690 ENOG4108TGY Glutathione S-transferase FOC83_03695 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC83_03700 ENOG4106BRA Membrane FOC83_03710 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FOC83_03735 ENOG4105CBN LysR family transcriptional regulator FOC83_03740 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC83_03745 ENOG4105CHU acetyl-coa acetyltransferase FOC83_03750 ENOG4105CC9 acyl-Coa dehydrogenase FOC83_03755 ENOG4105C1G acyl-Coa dehydrogenase FOC83_03760 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_03765 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC83_03770 ENOG4105K6H D-cysteine desulfhydrase FOC83_03785 ENOG4105F04 LysR family Transcriptional regulator FOC83_03795 ENOG4108VHT MarR family transcriptional regulator FOC83_03800 ENOG41079KZ Major Facilitator Superfamily FOC83_03805 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FOC83_03810 ENOG4108XHQ (2Fe-2S)-binding domain protein FOC83_03830 ENOG4108UAU isochorismatase FOC83_03835 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FOC83_03845 ENOG4105F7P transcriptional regulator AsnC family FOC83_03850 ENOG4108Z9W Outer membrane porin FOC83_03855 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_03860 ENOG4105C4Y ABC transporter FOC83_03865 ENOG4105E0C molybdate abc transporter FOC83_03875 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FOC83_03880 ENOG4105CBS Chea signal transduction histidine kinase FOC83_03890 ENOG4108KTQ Methyltransferase FOC83_03900 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_03905 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC83_03920 ENOG4105CC0 LysR family Transcriptional regulator FOC83_03940 ENOG4105F2V VRR-NUC domain-containing protein FOC83_03950 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC83_03965 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FOC83_04015 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) FOC83_04035 ENOG4106IQC argininosuccinate lyase FOC83_04050 ENOG4105EJC lysr family transcriptional regulator FOC83_04055 ENOG4108Z6Z Transcriptional regulator FOC83_04065 ENOG4105JJR Histidine kinase FOC83_04085 ENOG4105R1U AraC Family Transcriptional Regulator FOC83_04090 ENOG4105D74 hydrolase FOC83_04100 ENOG4105EMU Dehydrogenase FOC83_04105 ENOG4105CF7 AraC family transcriptional regulator FOC83_04135 ENOG4105MHT Transcriptional regulator, ARSR family FOC83_04140 ENOG4105WAB arsR family transcriptional regulator FOC83_04150 ENOG4105DAE Methylenetetrahydrofolate reductase FOC83_04155 ENOG4105DZ2 Transcriptional regulator FOC83_04160 ENOG4108UZX fmn reductase FOC83_04225 ENOG4108ZXE FOC83_04265 ENOG4108ZIT Ferredoxin, 2FE-2S FOC83_04280 ENOG4105KTU Transcriptional regulator, arsr family FOC83_04285 ENOG4107Y80 Major Facilitator superfamily FOC83_04295 ENOG4105PGM cation diffusion facilitator family transporter FOC83_04300 ENOG4107YCR Transcriptional regulator, ARSR family FOC83_04315 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC83_04325 ENOG4105DXI Major Facilitator superfamily FOC83_04335 ENOG41067VN Glutaredoxin FOC83_04360 ENOG4107QJE Chromosome Partitioning Protein FOC83_04400 ENOG4105FA0 parb-like partition protein FOC83_04485 ENOG4105DFP Integrase FOC83_04535 ENOG4105D6J arsenicaL-resistance protein FOC83_04600 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC83_04605 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC83_04630 ENOG4107RSM transcriptional regulator FOC83_04640 ENOG4105C5I Dehydrogenase FOC83_04670 ENOG4105EMY transcriptional regulator FOC83_04680 ENOG4105DV0 amidase (EC 3.5.1.4 FOC83_04980 ENOG4105DH7 May be involved in recombination (By similarity) FOC83_04985 ENOG4107WZZ SMC domain protein FOC83_05045 ENOG4105E1J oxidoreductase FOC83_05050 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC83_05055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC83_05060 ENOG4105C3U ABC transporter FOC83_05065 ENOG4108JQ7 (ABC) transporter FOC83_05070 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC83_05085 ENOG4105F04 LysR family Transcriptional regulator FOC83_05095 ENOG4105DG4 malate L-lactate dehydrogenase FOC83_05150 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FOC83_05170 ENOG4105CI0 Citrate lyase FOC83_05175 ENOG4105DND Transcriptional regulator FOC83_05195 ENOG4105CNM Receptor FOC83_05230 ENOG4108K0B C-di-gmp phosphodiesterase FOC83_05235 ENOG4105E0K tonB-dependent siderophore receptor FOC83_05240 ENOG4105E0K tonB-dependent siderophore receptor FOC83_05255 ENOG4105CBN LysR family transcriptional regulator FOC83_05280 ENOG4105ZRN FOC83_05295 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC83_05305 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FOC83_05325 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FOC83_05340 ENOG4105CC0 LysR family Transcriptional regulator FOC83_05345 ENOG4105BZU Histidine kinase FOC83_05380 ENOG4107YNJ LysR family Transcriptional regulator FOC83_05385 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC83_05395 ENOG4105DTD Dehydrogenase FOC83_05405 ENOG41082CG Protein CrcB homolog FOC83_05415 ENOG4107YNJ LysR family Transcriptional regulator FOC83_05430 ENOG4105DHQ Histidine kinase FOC83_05435 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC83_05450 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_05455 ENOG4108SF5 RNA Polymerase FOC83_05460 ENOG4108S3W Anti-feci sigma factor, fecr FOC83_05465 ENOG4105E0K tonB-dependent siderophore receptor FOC83_05470 ENOG4108ETH Formylglycinamide ribotide synthetase FOC83_05480 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC83_05485 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FOC83_05490 ENOG4108RRZ Transcription elongation factor GreB FOC83_05495 ENOG4105DB7 PHP domain protein FOC83_05510 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC83_05520 ENOG4105DND Transcriptional regulator FOC83_05530 ENOG4105DUM transcriptional regulator, lysR family FOC83_05535 ENOG4105CSH Transporter FOC83_05540 ENOG4107S4Y M20 DapE family protein YgeY FOC83_05545 ENOG4108EC8 DNA internalization-related competence protein ComEC FOC83_05550 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FOC83_05560 ENOG4108MGI Transcriptional regulator FOC83_05575 ENOG4105CXG d-lactate dehydrogenase FOC83_05625 ENOG4105VG5 Membrane FOC83_05630 ENOG4105JP4 Inner membrane protein yidG FOC83_05635 ENOG41082AG Plasmid maintenance system antidote protein FOC83_05660 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC83_05670 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FOC83_05675 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FOC83_05710 ENOG4105E6M Sulphatase-modifying factor protein FOC83_05715 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC83_05750 ENOG4105ENH Sulfatase FOC83_05760 ENOG4105N14 lysine exporter protein LysE YggA FOC83_05790 ENOG4108ZIT Ferredoxin, 2FE-2S FOC83_05795 ENOG4105DTD Dehydrogenase FOC83_05800 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC83_05810 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC83_05835 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FOC83_05840 ENOG4105E0K tonB-dependent siderophore receptor FOC83_05845 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FOC83_05850 ENOG4108IPW abc transporter atp-binding protein FOC83_05855 ENOG4105CM4 permease protein FOC83_05860 ENOG4105DHS permease protein FOC83_05870 ENOG4105D05 Receptor FOC83_05875 ENOG4105E3W Two component transcriptional regulator (Winged helix family FOC83_05880 ENOG410804D Sensor Signal Transduction Histidine Kinase FOC83_05885 ENOG4105F8V Hydrolase, tatD family FOC83_05890 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC83_05905 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC83_05910 ENOG4105CSP Major Facilitator Superfamily FOC83_05920 ENOG410904N short-chain dehydrogenase reductase FOC83_05925 ENOG4105CRK lysyL-tRNA synthetase FOC83_05940 ENOG4105DKK Benzoate FOC83_05945 ENOG4105DFA alanine racemase domain protein FOC83_05950 ENOG4108RZE Tetr family transcriptional regulator FOC83_05955 ENOG4105CHU acetyl-coa acetyltransferase FOC83_05960 ENOG4108IQE Amp-dependent synthetase and ligase FOC83_05965 ENOG4108IV0 ABC, transporter FOC83_05985 ENOG4105C0Z ABC transporter FOC83_05990 ENOG4105CGU Enoyl-CoA hydratase FOC83_06000 ENOG4108Z5K methylglyoxal synthase FOC83_06005 ENOG4105WVQ Fe-S assembly protein IscX FOC83_06010 ENOG4108ZIT Ferredoxin, 2FE-2S FOC83_06015 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB FOC83_06020 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) FOC83_06025 ENOG4108Z4V iron-sulfur cluster assembly FOC83_06030 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FOC83_06035 ENOG4105C3J Cysteine desulfurase FOC83_06050 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC83_06055 ENOG4105CGF Aromatic amino acid aminotransferase FOC83_06060 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FOC83_06065 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FOC83_06070 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FOC83_06075 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC83_06080 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC83_06085 ENOG4108K0D peptidase, M48 FOC83_06090 ENOG4108TEB UPF0114 protein FOC83_06095 ENOG4105VEQ Cold shock protein FOC83_06105 ENOG4105VEQ Cold shock protein FOC83_06130 ENOG4105KME endoribonuclease L-psp FOC83_06140 ENOG4105EJC lysr family transcriptional regulator FOC83_06155 ENOG4108IG5 Transcriptional regulator FOC83_06175 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC83_06415 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC83_06430 ENOG4105UZW Tail fiber assembly protein FOC83_06515 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FOC83_06540 ENOG4108N8X transition metal ion binding FOC83_06545 ENOG4105WEF catalase FOC83_06560 ENOG4105FA0 parb-like partition protein FOC83_06640 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FOC83_06650 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FOC83_06655 ENOG4105C5H ABC transporter FOC83_06670 ENOG4105PE1 Receptor FOC83_06675 ENOG4105PE1 Receptor FOC83_06685 ENOG4105PE1 Receptor FOC83_06705 ENOG4105C4R Atp-dependent dna helicase FOC83_06725 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC83_06730 ENOG4105DTN riboflavin biosynthesis protein ribF FOC83_06735 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC83_06740 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FOC83_06745 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC83_06765 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) FOC83_06795 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC83_06830 ENOG4108Z9K Osmotically inducible protein FOC83_06835 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC83_06840 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC83_06845 ENOG4105CYM Glutathione S-transferase FOC83_06865 ENOG4105DCM major facilitator superfamily FOC83_06870 ENOG4108IV0 ABC, transporter FOC83_06875 ENOG4105C0Z ABC transporter FOC83_06880 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC83_06885 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_06895 ENOG4105C26 Dehydrogenase FOC83_06905 ENOG4105DY2 Paraquat-inducible protein b FOC83_06910 ENOG4105F1S paraquat-inducible protein a FOC83_06920 ENOG4108JQB penicillin-binding protein 1C FOC83_06925 ENOG4105DN3 alpha-2-macroglobulin domain protein FOC83_06930 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FOC83_06935 ENOG4105VEQ Cold shock protein FOC83_06945 ENOG4105CHU acetyl-coa acetyltransferase FOC83_06950 ENOG4105CMQ Chloride channel FOC83_06955 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_06960 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC83_06970 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FOC83_06985 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FOC83_06995 ENOG4105W49 UPF0434 protein FOC83_07000 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FOC83_07015 ENOG4105CJR Integral membrane protein (MviN FOC83_07025 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) FOC83_07030 ENOG4105RQF LysR family Transcriptional regulator FOC83_07040 ENOG4105CNV Aldolase FOC83_07050 ENOG4105DG4 malate L-lactate dehydrogenase FOC83_07055 ENOG4107YCY Transcriptional regulator FOC83_07075 ENOG4105C5I Dehydrogenase FOC83_07090 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC83_07105 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase FOC83_07110 ENOG4105C26 Dehydrogenase FOC83_07135 ENOG4105CHR reductase FOC83_07140 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC83_07160 ENOG4108ARY Protein CrcB homolog FOC83_07195 ENOG4105EQN UPF0261 protein FOC83_07220 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC83_07230 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FOC83_07240 ENOG4105CSH Transporter FOC83_07260 ENOG4108YZ4 nudix hydrolase FOC83_07265 ENOG4105CR8 Transcriptional regulator FOC83_07270 ENOG4105R8A Heat shock protein FOC83_07285 ENOG4105CNM Receptor FOC83_07290 ENOG4105CNM Receptor FOC83_07295 ENOG4105WPR Transcriptional regulator, ARAC family FOC83_07305 ENOG4105DXI Major Facilitator superfamily FOC83_07315 ENOG4105VRT cytoplasmic protein FOC83_07330 ENOG4108TGY Glutathione S-transferase FOC83_07350 ENOG4105GAK amidohydrolase 2 FOC83_07365 ENOG4108JQ1 Dehydrogenase FOC83_07425 ENOG4108XM1 transcriptional regulator AsnC family FOC83_07435 ENOG4108JQ6 ABC transporter FOC83_07450 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC83_07460 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC83_07475 ENOG4108SF5 RNA Polymerase FOC83_07495 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC83_07505 ENOG4105CVE Lytic murein transglycosylase FOC83_07515 ENOG4105DDW LysR family Transcriptional regulator FOC83_07525 ENOG4105EBR Carboxylesterase FOC83_07545 ENOG4105CH2 amidohydrolase FOC83_07565 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) FOC83_07580 ENOG4105GAK amidohydrolase 2 FOC83_07590 ENOG4105BZU Histidine kinase FOC83_07595 ENOG4105VEJ Heat shock protein FOC83_07600 ENOG4105CSR polyphosphate kinase 2 FOC83_07620 ENOG4108UMI ABC transporter, permease FOC83_07625 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC83_07630 ENOG4105D01 (LipO)protein FOC83_07640 ENOG4105DNH Major Facilitator FOC83_07650 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FOC83_07655 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC83_07675 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC83_07695 ENOG4105EZR dyp-type peroxidase family protein FOC83_07745 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC83_07755 ENOG4105CBN LysR family transcriptional regulator FOC83_07760 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC83_07795 ENOG4108UT2 hemolysin iii FOC83_07805 ENOG4105VEQ Cold shock protein FOC83_07835 ENOG4105DVW rieske (2Fe-2S) FOC83_07850 ENOG4108JA1 polyketide synthase FOC83_07865 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_07870 ENOG4108NDG TRAP dicarboxylate FOC83_07880 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC83_07885 ENOG4108ZXC Two component transcriptional regulator, luxr family FOC83_07895 ENOG4105CHU acetyl-coa acetyltransferase FOC83_07910 ENOG4105E3A (ABC) transporter FOC83_07915 ENOG4105DA5 (ABC) transporter FOC83_07920 ENOG4105BZU Histidine kinase FOC83_07925 ENOG4105WH1 Two component transcriptional regulator luxr family FOC83_07945 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FOC83_07965 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FOC83_07990 ENOG4105SG9 biopolymer transport protein, ExbD FOC83_07995 ENOG4105E02 MotA TolQ exbB proton channel FOC83_08060 ENOG4108S8N class II Aldolase FOC83_08110 ENOG4108UKI Enoyl-CoA hydratase FOC83_08125 ENOG4105CC0 LysR family Transcriptional regulator FOC83_08140 ENOG4105BZU Histidine kinase FOC83_08155 ENOG41061WM D-Alanyl-D-Alanine FOC83_08165 ENOG4105EXC Acyl-transferase FOC83_08180 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) FOC83_08210 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC83_08215 ENOG41069H7 transport system small permease component FOC83_08220 ENOG4105CH5 extracellular solute-binding protein, family 7 FOC83_08235 ENOG4105ETE Transcriptional regulator (LacI family FOC83_08240 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FOC83_08245 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC83_08255 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate FOC83_08270 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC83_08275 ENOG4105CSW GntR family transcriptional regulator FOC83_08280 ENOG4105CXN decarboxylase FOC83_08290 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family FOC83_08295 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FOC83_08310 ENOG4105CF7 AraC family transcriptional regulator FOC83_08315 ENOG4107U9B transcriptional regulator FOC83_08330 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC83_08415 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC83_08420 ENOG4108R85 Short chain dehydrogenase FOC83_08425 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FOC83_08435 ENOG4108JJ7 ABC transporter FOC83_08455 ENOG4105D64 Mechanosensitive ion channel FOC83_08465 ENOG4107QP8 phosphohexose isomerase FOC83_08500 ENOG4105X23 Endonuclease Exonuclease phosphatase FOC83_08505 ENOG4105DZQ phospholipase D Transphosphatidylase FOC83_08510 ENOG4107UXM Membrane FOC83_08515 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC83_08520 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FOC83_08525 ENOG4105CG3 alpha amylase, catalytic region FOC83_08530 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FOC83_08540 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FOC83_08545 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FOC83_08555 ENOG4105C85 amino acid FOC83_08560 ENOG4105DQE DNA ligase FOC83_08565 ENOG4105FDF Could be involved in DNA repair (By similarity) FOC83_08570 ENOG4105CEV competence damage-inducible protein FOC83_08580 ENOG4105BZU Histidine kinase FOC83_08605 ENOG4107S4Y M20 DapE family protein YgeY FOC83_08625 ENOG4105CSH Transporter FOC83_08640 ENOG4105D05 Receptor FOC83_08655 ENOG4108W0P ABC transporter FOC83_08660 ENOG4105EHG Permease protein FOC83_08680 ENOG4108UAJ Transcriptional regulator FOC83_08705 ENOG4105J4Q Transcriptional regulator FOC83_08710 ENOG4105ERH Fumarylacetoacetate hydrolase FOC83_08715 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FOC83_08725 ENOG4105CTX dehydratase FOC83_08735 ENOG4105DRP amino acid AbC transporter FOC83_08745 ENOG4105EAB amino acid AbC transporter FOC83_08750 ENOG4105DIA mandelate racemase muconate lactonizing FOC83_08760 ENOG4105E2X shikimate dehydrogenase FOC83_08765 ENOG4108IUS Transketolase FOC83_08770 ENOG4108HHA Transketolase FOC83_08775 ENOG4108WYP Transcriptional regulator FOC83_08780 ENOG4105DCT glycerol dehydrogenase FOC83_08785 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme FOC83_08790 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FOC83_08795 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC83_08805 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_08810 ENOG4105C0Z ABC transporter FOC83_08815 ENOG4108IV0 ABC, transporter FOC83_08825 ENOG4105CHR reductase FOC83_08840 ENOG4105JQN Transcriptional regulator FOC83_08855 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC83_08860 ENOG4105JQN Transcriptional regulator FOC83_08865 ENOG4107QM5 aconitate hydratase FOC83_08870 ENOG4105UYK outer membrane protein a FOC83_08885 ENOG4105CW7 secretion protein, HlyD family FOC83_08890 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC83_08900 ENOG4105W7K Transcriptional regulator FOC83_08905 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC83_08920 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FOC83_08935 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC83_09005 ENOG4105BZU Histidine kinase FOC83_09025 ENOG4108JQ6 ABC transporter FOC83_09030 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC83_09050 ENOG4105D7N magnesium and cobalt transport protein CorA FOC83_09070 ENOG4108JPW Aminotransferase FOC83_09075 ENOG4105C26 Dehydrogenase FOC83_09080 ENOG4105ECY inositol monophosphatase FOC83_09085 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC83_09090 ENOG4105D7W serine acetyltransferase FOC83_09095 ENOG4105CMR udp-glucose 4-epimerase FOC83_09100 ENOG4107QP8 phosphohexose isomerase FOC83_09105 ENOG4107QKV phosphomannomutase FOC83_09120 ENOG4105D3Q Sugar transferase FOC83_09125 ENOG4105FGF GDP-mannose mannosyl hydrolase FOC83_09130 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FOC83_09145 ENOG4105C30 Nad-dependent epimerase dehydratase FOC83_09165 ENOG4107T8Q Glycosyl transferase (Group 1 FOC83_09170 ENOG4106WTF Glycosyl transferase, family 2 FOC83_09175 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF FOC83_09180 ENOG4106CD9 glycosyl transferase group 1 FOC83_09185 ENOG4105WH1 Two component transcriptional regulator luxr family FOC83_09190 ENOG4105WH1 Two component transcriptional regulator luxr family FOC83_09200 ENOG4108XG4 DNA-binding transcriptional regulator FOC83_09205 ENOG4107QPN acyl-Coa dehydrogenase FOC83_09215 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC83_09230 ENOG4105CHU acetyl-coa acetyltransferase FOC83_09245 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_09265 ENOG4105BZ1 (ABC) transporter FOC83_09270 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) FOC83_09310 ENOG4105J4Q Transcriptional regulator FOC83_09315 ENOG4108T2C cysteine dioxygenase type I FOC83_09320 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC83_09340 ENOG4105HEI LysR family (Transcriptional regulator FOC83_09370 ENOG4108IJ6 ABC transporter FOC83_09375 ENOG4108RZE Tetr family transcriptional regulator FOC83_09390 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) FOC83_09400 ENOG4105BZU Histidine kinase FOC83_09405 ENOG4105BZU Histidine kinase FOC83_09410 ENOG4105BZU Histidine kinase FOC83_09430 ENOG4105NQN cytochrome C FOC83_09445 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i FOC83_09465 ENOG4105C58 cytochrome c oxidase accessory protein ccog FOC83_09495 ENOG4105CFH Aspartokinase FOC83_09500 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC83_09505 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FOC83_09515 ENOG4105C8N cysteinyl-tRNA synthetase FOC83_09530 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) FOC83_09535 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC83_09540 ENOG4105EE5 Membrane protein terC FOC83_09550 ENOG4105HEE Binding Domain protein FOC83_09555 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) FOC83_09565 ENOG4105CIG ABC transporter FOC83_09570 ENOG4108T0W nitrous oxide maturation protein NosY FOC83_09580 ENOG4105CJ2 (LipO)protein FOC83_09585 ENOG4105DFS Conserved Protein FOC83_09590 ENOG4105ECY inositol monophosphatase FOC83_09610 ENOG4105D64 Mechanosensitive ion channel FOC83_09650 ENOG4105GVF (ABC) transporter FOC83_09660 ENOG4108IY8 ABC, transporter FOC83_09695 ENOG4105WKW Pfam:DUF1458 FOC83_09705 ENOG4105CC0 LysR family Transcriptional regulator FOC83_09710 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC83_09770 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FOC83_09775 ENOG4105EZE Cupin 4 family protein FOC83_09785 ENOG4105GJM (LipO)protein FOC83_09790 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC83_09795 ENOG4108Z4T Peptidase M50 FOC83_09800 ENOG4107RTD sua5 ycio yrdc ywlc family protein FOC83_09805 ENOG4105CGZ zinc metallopeptidase FOC83_09865 ENOG4108Z7R Chaperone CsaA FOC83_09870 ENOG4105BZV Phosphoadenosine phosphosulfate reductase FOC83_09880 ENOG4105GTN ParB Domain Protein Nuclease FOC83_09885 ENOG4105DHQ Histidine kinase FOC83_09890 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC83_09910 ENOG4108TTM chaperone FOC83_09925 ENOG4105BZU Histidine kinase FOC83_09930 ENOG4105BZU Histidine kinase FOC83_09935 ENOG41068CG regulatoR FOC83_09965 ENOG4108S1B Periplasmic chaperone protein FOC83_09970 ENOG4105E6S usher protein( FOC83_10015 ENOG4105BZP glycoside hydrolase 15-related FOC83_10025 ENOG4105I03 Flagellin FOC83_10030 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_10040 ENOG4108NIW Leucine export protein LeuE FOC83_10065 ENOG41061CV Terminase small subunit FOC83_10110 ENOG4107R08 Integrase FOC83_10120 ENOG4105DZQ phospholipase D Transphosphatidylase FOC83_10140 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC83_10160 ENOG4108SF5 RNA Polymerase FOC83_10175 ENOG4107XBN GntR Family Transcriptional Regulator FOC83_10185 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC83_10190 ENOG4105C0H protease FOC83_10220 ENOG4105E0F Histidine kinase FOC83_10225 ENOG4108ZHJ Organic hydroperoxide resistance protein FOC83_10230 ENOG4105RQF LysR family Transcriptional regulator FOC83_10240 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC83_10245 ENOG4105C3U ABC transporter FOC83_10265 ENOG4108Z9W Outer membrane porin FOC83_10270 ENOG4108KF1 Membrane FOC83_10275 ENOG4107SQD Transcriptional regulator, GntR family FOC83_10280 ENOG4105RHY Pfam:UPF0157 FOC83_10340 ENOG4105CJP fad dependent oxidoreductase FOC83_10345 ENOG4105DRP amino acid AbC transporter FOC83_10355 ENOG4105EAB amino acid AbC transporter FOC83_10365 ENOG4105C26 Dehydrogenase FOC83_10385 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FOC83_10410 ENOG4105C58 cytochrome c oxidase accessory protein ccog FOC83_10430 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i FOC83_10445 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC83_10450 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC83_10480 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FOC83_10485 ENOG4105CA0 peroxidase FOC83_10490 ENOG4105EJC lysr family transcriptional regulator FOC83_10495 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC83_10505 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC83_10520 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FOC83_10525 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FOC83_10530 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC83_10535 ENOG4105BZS acriflavin resistance protein FOC83_10540 ENOG4105C1P efflux transporter, rnd family, mfp subunit FOC83_10560 ENOG4105F4R Transcriptional regulator mode FOC83_10565 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_10570 ENOG4105E0C molybdate abc transporter FOC83_10575 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC83_10580 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC83_10615 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC83_10625 ENOG4105C7J ABC transporter, permease FOC83_10635 ENOG4105CPC Aldo Keto reductase FOC83_10645 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_10650 ENOG4105E39 Enoyl-CoA hydratase FOC83_10660 ENOG4105DRR Transcriptional regulator, GntR family FOC83_10670 ENOG4105CHU acetyl-coa acetyltransferase FOC83_10675 ENOG4105D2B acyl-CoA dehydrogenase FOC83_10680 ENOG4105D2B acyl-CoA dehydrogenase FOC83_10685 ENOG4105DUM transcriptional regulator, lysR family FOC83_10705 ENOG4105TW1 Carbohydrate-selective porin OprB FOC83_10710 ENOG4105DFW ABC transporter FOC83_10720 ENOG4108HWW ABC transporter FOC83_10725 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC83_10730 ENOG4105E9Z Nad-dependent epimerase dehydratase FOC83_10735 ENOG4105ETE Transcriptional regulator (LacI family FOC83_10745 ENOG4108IJ7 Glycine betaine FOC83_10750 ENOG4108HQS Glycine betaine FOC83_10760 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC83_10765 ENOG4105C2C drug resistance transporter, Bcr CflA FOC83_10770 ENOG4105KDC 50s ribosomal protein l28 FOC83_10775 ENOG4105W0E 50S ribosomal protein L33 FOC83_10790 ENOG4105C0Z ABC transporter FOC83_10810 ENOG4105DZ1 carboxypeptidase FOC83_10825 ENOG4108VHT MarR family transcriptional regulator FOC83_10835 ENOG4105C8T Leucyl-tRNA synthetase FOC83_10850 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FOC83_10870 ENOG4105EUF amidase EC 3.5.1.4 FOC83_10880 ENOG4105C57 major facilitator superfamily FOC83_10890 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FOC83_10915 ENOG4105MP9 class II Aldolase FOC83_10955 ENOG4105ETT transcriptional Regulator, LysR family FOC83_10960 ENOG4105CYC Transferase FOC83_10965 ENOG4105CMU LysR family (Transcriptional regulator FOC83_10970 ENOG4105EGS Mechanosensitive ion channel FOC83_11000 ENOG4107SDU Methyl-accepting chemotaxis FOC83_11020 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_11025 ENOG4105F38 ABC transporter, permease FOC83_11030 ENOG4105D38 putrescine abc transporter FOC83_11035 ENOG4105CTU Proline racemase FOC83_11050 ENOG41080XP Cbs domain FOC83_11070 ENOG4107QIJ Aconitate hydratase 2 FOC83_11080 ENOG4105FQ6 thiopurine methyltransferase FOC83_11110 ENOG4105CPC Aldo Keto reductase FOC83_11115 ENOG4105CF7 AraC family transcriptional regulator FOC83_11120 ENOG4105HEI LysR family (Transcriptional regulator FOC83_11125 ENOG4105CHJ isochorismatase hydrolase FOC83_11135 ENOG4105Z2P Protein of unknown function (DUF465) FOC83_11150 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FOC83_11155 ENOG4105CPK Glycosyl transferase (Group 1 FOC83_11175 ENOG4107SQD Transcriptional regulator, GntR family FOC83_11180 ENOG4105C3J Cysteine desulfurase FOC83_11185 ENOG4105E39 Enoyl-CoA hydratase FOC83_11215 ENOG4107F9Y LysR family transcriptional regulator FOC83_11225 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC83_11235 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_11245 ENOG4105C0Z ABC transporter FOC83_11250 ENOG4108IV0 ABC, transporter FOC83_11255 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC83_11265 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC83_11280 ENOG4105E39 Enoyl-CoA hydratase FOC83_11305 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC83_11315 ENOG4107QX3 carboxylase FOC83_11355 ENOG4105CSU acyl-Coa dehydrogenase FOC83_11360 ENOG4108UKI Enoyl-CoA hydratase FOC83_11365 ENOG4105FDR Membrane FOC83_11370 ENOG4105E39 Enoyl-CoA hydratase FOC83_11375 ENOG4108IPT Naphthoate synthase FOC83_11380 ENOG4108R85 Short chain dehydrogenase FOC83_11390 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC83_11395 ENOG4105D2S major facilitator superfamily FOC83_11410 ENOG4108SY4 MarR family Transcriptional regulator FOC83_11415 ENOG4105C7B Threonine dehydratase FOC83_11430 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FOC83_11435 ENOG4105CHU acetyl-coa acetyltransferase FOC83_11445 ENOG4105C1G acyl-Coa dehydrogenase FOC83_11450 ENOG4105EJC lysr family transcriptional regulator FOC83_11465 ENOG4105D2S major facilitator superfamily FOC83_11470 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC83_11475 ENOG4105E2Z phosphate ABC transporter (Permease FOC83_11480 ENOG4105C8U phosphate abc transporter FOC83_11485 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FOC83_11495 ENOG4105C9X ppx gppa phosphatase FOC83_11505 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FOC83_11515 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC83_11520 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FOC83_11525 ENOG4105HBR Rna-binding protein FOC83_11530 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FOC83_11535 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_11540 ENOG4105C2W permease FOC83_11550 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC FOC83_11560 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_11575 ENOG4105EMU Dehydrogenase FOC83_11585 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FOC83_11590 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC83_11605 ENOG4105BZU Histidine kinase FOC83_11610 ENOG4105ETX regulatoR FOC83_11625 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC83_11635 ENOG4105D2X ABC transporter substrate-binding protein FOC83_11640 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC83_11655 ENOG4107QMP dna polymerase iii subunits gamma and tau FOC83_11665 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC83_11685 ENOG4105EA8 2-Nitropropane dioxygenase FOC83_11705 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC83_11720 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC83_11725 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_11740 ENOG41061WM D-Alanyl-D-Alanine FOC83_11755 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FOC83_11760 ENOG4108Z66 YbaK ebsC protein FOC83_11765 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC83_11770 ENOG4105ETT transcriptional Regulator, LysR family FOC83_11775 ENOG4105C7K acetolactate synthase FOC83_11780 ENOG4105C1G acyl-Coa dehydrogenase FOC83_11820 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FOC83_11845 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_11855 ENOG4105C0Z ABC transporter FOC83_11860 ENOG4108IV0 ABC, transporter FOC83_11870 ENOG4107QXX ABC transporter FOC83_11885 ENOG4107QNJ CoA-transferase subunit B FOC83_11890 ENOG4107HP6 Transcriptional regulator FOC83_11895 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC83_11900 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC83_11905 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC83_11910 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FOC83_11920 ENOG4105C8V SAICAR synthetase FOC83_11940 ENOG4105CK2 sodium dicarboxylate symporter FOC83_11950 ENOG4105FD8 phosphonate metabolism protein PhnM FOC83_11955 ENOG4105HRV phosphonate c-p lyase system protein phnl FOC83_11960 ENOG4105ENV phosphonate C-P lyase system protein PhnK FOC83_11965 ENOG4105FT8 Phosphonate metabolism FOC83_11975 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH FOC83_11980 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG FOC83_11985 ENOG4107RJJ Transcriptional regulator FOC83_11990 ENOG4105FD8 phosphonate metabolism protein PhnM FOC83_11995 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FOC83_12000 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FOC83_12005 ENOG410811B TRANSCRIPTIONal FOC83_12010 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC83_12030 ENOG4105EHI Phosphonate ABC transporter, periplasmic FOC83_12035 ENOG4105D5T phosphonate abc transporter FOC83_12045 ENOG4105MHT Transcriptional regulator, ARSR family FOC83_12055 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FOC83_12065 ENOG4105DR5 peptidase FOC83_12075 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC83_12085 ENOG4105CJ3 phosphate transporter FOC83_12110 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) FOC83_12120 ENOG4108SHQ Glutathione S-transferase FOC83_12140 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC83_12145 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FOC83_12160 ENOG4105BZA Phosphoglycerate kinase FOC83_12165 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC83_12170 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOC83_12180 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC83_12195 ENOG4105C6K Malic enzyme FOC83_12220 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FOC83_12225 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FOC83_12240 ENOG4105TNS Conserved Protein FOC83_12250 ENOG4105D7T ABC transporter FOC83_12260 ENOG4105I5W Transporter FOC83_12265 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC83_12270 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FOC83_12275 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FOC83_12300 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FOC83_12305 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FOC83_12320 ENOG4105VIE preprotein translocase, subunit YajC FOC83_12325 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC83_12330 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC83_12350 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC83_12360 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC83_12365 ENOG4105C9A Phoh family FOC83_12370 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FOC83_12375 ENOG4108JU5 Magnesium and cobalt efflux protein FOC83_12380 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FOC83_12385 ENOG4107SET aldo keto reductase FOC83_12420 ENOG4108UAJ Transcriptional regulator FOC83_12430 ENOG4108TZV Membrane FOC83_12450 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FOC83_12460 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC83_12470 ENOG4108ZAF Molybdopterin FOC83_12475 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC83_12480 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC83_12490 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC83_12505 ENOG4107QIZ NADH dehydrogenase FOC83_12510 ENOG4108IEG Formate dehydrogenase Alpha subunit FOC83_12515 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC83_12550 ENOG4106NZI LysR family Transcriptional regulator FOC83_12555 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC83_12560 ENOG41068KF Universal stress protein FOC83_12570 ENOG4105IFJ Histidine kinase FOC83_12575 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC83_12590 ENOG4105E3J oxidoreductase FOC83_12605 ENOG4105CHR reductase FOC83_12625 ENOG4105C7F AcnD-accessory protein PrpF FOC83_12630 ENOG4105F04 LysR family Transcriptional regulator FOC83_12635 ENOG41080E2 ribosomal-protein-alanine acetyltransferase FOC83_12670 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein FOC83_12675 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_12685 ENOG4105C0Z ABC transporter FOC83_12690 ENOG4108IV0 ABC, transporter FOC83_12700 ENOG4105E0K tonB-dependent siderophore receptor FOC83_12720 ENOG4108XG2 Histidine kinase FOC83_12725 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC83_12730 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC83_12740 ENOG4108VPT UPF0234 protein FOC83_12745 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FOC83_12750 ENOG4105EHG Permease protein FOC83_12755 ENOG4107R4I Periplasmic binding protein FOC83_12760 ENOG4106QJH hemin transport protein FOC83_12770 ENOG4108S3W Anti-feci sigma factor, fecr FOC83_12775 ENOG4108SF5 RNA Polymerase FOC83_12790 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC83_12815 ENOG4105CBN LysR family transcriptional regulator FOC83_12820 ENOG4105C85 amino acid FOC83_12830 ENOG4105F7P transcriptional regulator AsnC family FOC83_12835 ENOG4108UT2 hemolysin iii FOC83_12840 ENOG4105KXX peptidase s58 dmpa FOC83_12845 ENOG4105EAB amino acid AbC transporter FOC83_12850 ENOG4105E5Q amino acid AbC transporter FOC83_12855 ENOG4105CDA abc transporter atp-binding protein FOC83_12860 ENOG4108K5P (LipO)protein FOC83_12895 ENOG4105TX3 Histidine kinase FOC83_12900 ENOG4108UYB regulatoR FOC83_12905 ENOG4105E2S oxidase) subunit II FOC83_12910 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC83_12915 ENOG4105CCU oxidase (Subunit III) FOC83_12920 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FOC83_12930 ENOG4105CHB tonB-dependent Receptor FOC83_12950 ENOG4105C6K Malic enzyme FOC83_12965 ENOG4108PCN EamA-like transporter family FOC83_12985 ENOG4105DUM transcriptional regulator, lysR family FOC83_13000 ENOG4105CHR reductase FOC83_13010 ENOG4107NQ8 LysR family Transcriptional regulator FOC83_13030 ENOG4108JCI Transcriptional regulator FOC83_13035 ENOG4107RZC phospholipase d FOC83_13045 ENOG4105CF1 Alkylated DNA repair protein FOC83_13075 ENOG4105F1J Homogentisate 1,2-dioxygenase FOC83_13080 ENOG4108302 MgtC SapB transporter FOC83_13085 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC83_13090 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FOC83_13105 ENOG4107QM5 aconitate hydratase FOC83_13120 ENOG4108S3W Anti-feci sigma factor, fecr FOC83_13125 ENOG4108SF5 RNA Polymerase FOC83_13130 ENOG4108MP6 LysR family Transcriptional regulator FOC83_13135 ENOG4107GJV short-chain dehydrogenase reductase FOC83_13140 ENOG4105CNM Receptor FOC83_13160 ENOG4105BZU Histidine kinase FOC83_13165 ENOG4105EPW hflc protein FOC83_13180 ENOG4105D4Y metalloprotease FOC83_13190 ENOG4105DJ2 Major Facilitator Superfamily FOC83_13195 ENOG4105R1U AraC Family Transcriptional Regulator FOC83_13200 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FOC83_13210 ENOG4105DU1 integral membrane protein, terc FOC83_13215 ENOG41063Z6 transcriptional regulator, lysR family FOC83_13245 ENOG4108S3W Anti-feci sigma factor, fecr FOC83_13260 ENOG41067B5 Histone deacetylase superfamily protein FOC83_13280 ENOG4105CSH Transporter FOC83_13285 ENOG4105E2S oxidase) subunit II FOC83_13290 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC83_13295 ENOG4105CCU oxidase (Subunit III) FOC83_13300 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FOC83_13310 ENOG4108Z9W Outer membrane porin FOC83_13315 ENOG4108Z9W Outer membrane porin FOC83_13320 ENOG4108Z9W Outer membrane porin FOC83_13330 ENOG4105E5M Multidrug resistance protein D FOC83_13380 ENOG4105HSS phospholipase C FOC83_13405 ENOG4107QZF nitrite reductase NADPH large subunit FOC83_13410 ENOG4107QZF nitrite reductase NADPH large subunit FOC83_13415 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FOC83_13425 ENOG4105CPC Aldo Keto reductase FOC83_13440 ENOG4105CV8 reductase FOC83_13445 ENOG4105HEI LysR family (Transcriptional regulator FOC83_13465 ENOG4105EJC lysr family transcriptional regulator FOC83_13470 ENOG4105CMJ mandelate racemase muconate lactonizing FOC83_13485 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_13490 ENOG410620I Diguanylate cyclase FOC83_13495 ENOG4105MHT Transcriptional regulator, ARSR family FOC83_13505 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC83_13510 ENOG4105C6X Major Facilitator FOC83_13540 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC83_13550 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FOC83_13555 ENOG4105K5X acetyltransferase FOC83_13560 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC83_13575 ENOG4108M0I Transcriptional regulator FOC83_13585 ENOG4105MP9 class II Aldolase FOC83_13630 ENOG4105PGM cation diffusion facilitator family transporter FOC83_13650 ENOG4105BZ1 (ABC) transporter FOC83_13665 ENOG4107T0X DNA ligase FOC83_13670 ENOG4107T0X DNA ligase FOC83_13700 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase FOC83_13710 ENOG4105C1G acyl-Coa dehydrogenase FOC83_13720 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC83_13725 ENOG4108PCN EamA-like transporter family FOC83_13730 ENOG4105CWC Acetylornithine deacetylase FOC83_13750 ENOG4105C5Q Transcriptional regulator FOC83_13755 ENOG410642W LysR family Transcriptional regulator FOC83_13780 ENOG4105F52 Transcriptional regulator FOC83_13785 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC83_13795 ENOG4105CMJ mandelate racemase muconate lactonizing FOC83_13805 ENOG4108Z9W Outer membrane porin FOC83_13810 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_13855 ENOG4108SF5 RNA Polymerase FOC83_13885 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FOC83_13890 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FOC83_13900 ENOG4108U05 Transcriptional regulator FOC83_13915 ENOG4105DUM transcriptional regulator, lysR family FOC83_13945 ENOG4108IUZ ABC transporter FOC83_13950 ENOG4108IV0 ABC, transporter FOC83_13955 ENOG4105DEI Mannitol dehydrogenase FOC83_13960 ENOG41080IJ Diacylglycerol kinase FOC83_13965 ENOG4105CEP NADH dehydrogenase FOC83_13970 ENOG4105SKN orotidine 5''-phosphate decarboxylase FOC83_13975 ENOG4107TH8 cina domain protein FOC83_13985 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FOC83_13990 ENOG4107YIM Involved in the transcription termination process (By similarity) FOC83_13995 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FOC83_14000 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FOC83_14020 ENOG4105D5T phosphonate abc transporter FOC83_14050 ENOG4106H78 methyltransferase FOC83_14055 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FOC83_14060 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FOC83_14065 ENOG4105DKK Benzoate FOC83_14100 ENOG4105CNM Receptor FOC83_14105 ENOG4105DFS Conserved Protein FOC83_14135 ENOG4105CVR type I restriction-modification system FOC83_14140 ENOG4107SCJ type I restriction enzyme EcoKI subunit R FOC83_14155 ENOG4105C3G gtp-binding protein FOC83_14165 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC83_14185 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FOC83_14190 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_14200 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein FOC83_14205 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC83_14230 ENOG4105F1J Homogentisate 1,2-dioxygenase FOC83_14240 ENOG4106HNH Acyl-transferase FOC83_14245 ENOG4105E0M Sulfatase FOC83_14250 ENOG4107YCY Transcriptional regulator FOC83_14255 ENOG4105E9Z Nad-dependent epimerase dehydratase FOC83_14265 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FOC83_14275 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC83_14290 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC83_14295 ENOG4105CQB FAD linked oxidase domain protein FOC83_14305 ENOG4107QKV phosphomannomutase FOC83_14310 ENOG4107QP8 phosphohexose isomerase FOC83_14315 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC83_14320 ENOG4105CGN Glycosyl transferase (Group 1 FOC83_14325 ENOG4108KMV Glycosyl transferase (Group 1 FOC83_14330 ENOG4107STW synthase FOC83_14340 ENOG4105CG5 Glycosyl transferase (Group 1 FOC83_14355 ENOG4107QQG Dehydrogenase FOC83_14360 ENOG4107UKG Glycosyl transferase, family 4 FOC83_14380 ENOG4105BZU Histidine kinase FOC83_14390 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC83_14395 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC83_14400 ENOG4105C26 Dehydrogenase FOC83_14425 ENOG4108JQ6 ABC transporter FOC83_14430 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC83_14470 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FOC83_14475 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FOC83_14480 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FOC83_14490 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC83_14495 ENOG4105CBX hi0933 family FOC83_14500 ENOG4105CXN decarboxylase FOC83_14515 ENOG4105BZU Histidine kinase FOC83_14525 ENOG4105DHP deoxycytidine triphosphate deaminase FOC83_14550 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC83_14555 ENOG4105C72 UPF0176 protein FOC83_14570 ENOG4105EXC Acyl-transferase FOC83_14580 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC83_14585 ENOG4107SVH Potassium channel protein FOC83_14590 ENOG4108ZVF (LipO)protein FOC83_14605 ENOG4105CXC rtn protein FOC83_14615 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class FOC83_14620 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC83_14625 ENOG4105D0S secretion protein (HlyD FOC83_14630 ENOG4105CJ1 ABC, transporter FOC83_14635 ENOG4105CMI transporter FOC83_14645 ENOG4105CHR reductase FOC83_14650 ENOG4105CC0 LysR family Transcriptional regulator FOC83_14655 ENOG4108KTG Membrane protein, drug metabolite transporter FOC83_14660 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC83_14665 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC83_14675 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC83_14695 ENOG41079YP Citrate utilization protein b FOC83_14710 ENOG4105NQN cytochrome C FOC83_14720 ENOG4105CYM Glutathione S-transferase FOC83_14730 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC83_14735 ENOG4105CSH Transporter FOC83_14740 ENOG4105CGP Urocanate hydratase FOC83_14755 ENOG4105CD3 dihydroorotase FOC83_14780 ENOG4105YK5 50S ribosomal protein L36 FOC83_14790 ENOG4108I0Z Aconitate hydratase FOC83_14795 ENOG4105C7F AcnD-accessory protein PrpF FOC83_14800 ENOG4108SF5 RNA Polymerase FOC83_14805 ENOG4108S3W Anti-feci sigma factor, fecr FOC83_14810 ENOG4105CNM Receptor FOC83_14815 ENOG4105CH7 arginosuccinase FOC83_14820 ENOG4105JJR Histidine kinase FOC83_14830 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase FOC83_14860 ENOG4105CSH Transporter FOC83_14870 ENOG4105CHR reductase FOC83_14875 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme FOC83_14890 ENOG4105EVD ribosomal RNA large subunit methyltransferase N FOC83_14895 ENOG4105JSC dimethylmenaquinone methyltransferase FOC83_14900 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC83_14905 ENOG4105BZN citrate synthase FOC83_14910 ENOG4105CXK mandelate racemase muconate lactonizing FOC83_14955 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC83_14960 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC83_14970 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FOC83_14980 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FOC83_14990 ENOG4109066 lysm domain bon superfamily protein FOC83_14995 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FOC83_15000 ENOG4105CRE cytochrome C FOC83_15015 ENOG4108TGY Glutathione S-transferase FOC83_15050 ENOG4105C26 Dehydrogenase FOC83_15060 ENOG4105DFG type I secretion outer membrane protein FOC83_15065 ENOG4107QZV Type I secretion membrane fusion protein FOC83_15070 ENOG4108JJ6 Type I secretion system ATPase FOC83_15085 ENOG4105CAF HipA N-terminal domain protein FOC83_15105 ENOG4107HP6 Transcriptional regulator FOC83_15110 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 FOC83_15115 ENOG4108RTU Aldolase FOC83_15120 ENOG4105CXK mandelate racemase muconate lactonizing FOC83_15125 ENOG4105DJB Major Facilitator Superfamily FOC83_15130 ENOG4105CJ1 ABC, transporter FOC83_15150 ENOG4105F27 Major Facilitator FOC83_15155 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FOC83_15165 ENOG4105C2W permease FOC83_15180 ENOG4107QXX ABC transporter FOC83_15185 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC83_15200 ENOG4105CHR reductase FOC83_15310 ENOG4105BZU Histidine kinase FOC83_15330 ENOG4106NZI LysR family Transcriptional regulator FOC83_15340 ENOG4105NTW Transcriptional regulator FOC83_15360 ENOG4105II7 pyrroline-5-carboxylate reductase FOC83_15370 ENOG4105CQB FAD linked oxidase domain protein FOC83_15380 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_15385 ENOG4105F38 ABC transporter, permease FOC83_15390 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC83_15405 ENOG4105IPI Membrane FOC83_15410 ENOG4105CBN LysR family transcriptional regulator FOC83_15415 ENOG4105ENT Efflux transporter rnd family, mfp subunit FOC83_15425 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC83_15435 ENOG4105GP2 5'(3')-deoxyribonucleotidase FOC83_15445 ENOG4107YCY Transcriptional regulator FOC83_15455 ENOG4105E2X shikimate dehydrogenase FOC83_15465 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_15475 ENOG4105C0Z ABC transporter FOC83_15480 ENOG4108IV0 ABC, transporter FOC83_15490 ENOG4108JYK Dehydrogenase FOC83_15505 ENOG4107QN2 dihydrolipoyl dehydrogenase FOC83_15510 ENOG4105HEI LysR family (Transcriptional regulator FOC83_15515 ENOG4105C01 Dihydroxy-acid dehydratase FOC83_15525 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FOC83_15530 ENOG4105DUM transcriptional regulator, lysR family FOC83_15545 ENOG4105CXC rtn protein FOC83_15550 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FOC83_15555 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FOC83_15560 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC83_15565 ENOG4105CRW Short chain fatty acid transporter FOC83_15570 ENOG4105CHR reductase FOC83_15575 ENOG4107HP6 Transcriptional regulator FOC83_15585 ENOG4107QNJ CoA-transferase subunit B FOC83_15600 ENOG4105F2Z 3-oxoadipate enol-lactonase FOC83_15625 ENOG4108PVQ transcriptional regulator FOC83_15630 ENOG4105CHR reductase FOC83_15640 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_15670 ENOG4107NQ8 LysR family Transcriptional regulator FOC83_15675 ENOG4105C57 major facilitator superfamily FOC83_15700 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_15720 ENOG4105D01 (LipO)protein FOC83_15730 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FOC83_15740 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC83_15745 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC83_15760 ENOG410829K Lysine exporter protein (Lyse ygga) FOC83_15785 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FOC83_15790 ENOG4105UGU tonB-dependent Receptor FOC83_15800 ENOG4105CSH Transporter FOC83_15805 ENOG4105DDW LysR family Transcriptional regulator FOC83_15810 ENOG4107YCY Transcriptional regulator FOC83_15815 ENOG4105G63 Type III effector Hrp-dependent FOC83_15820 ENOG4105ZXK Dehydrogenase FOC83_15825 ENOG4105EXW epimerase dehydratase FOC83_15830 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FOC83_15835 ENOG4105FB2 class II Aldolase FOC83_15990 ENOG4105CMA conjugation trbi family protein FOC83_16055 ENOG4108XTF Outer Membrane Lipoprotein FOC83_16115 ENOG4105CPB ATP-dependent endonuclease of the OLD family FOC83_16120 ENOG4107R5R arsenical pump membrane protein FOC83_16135 ENOG4108UXE Protein tyrosine phosphatase FOC83_16150 ENOG4105E2Z phosphate ABC transporter (Permease FOC83_16155 ENOG4105C8U phosphate abc transporter FOC83_16160 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FOC83_16175 ENOG4105H3G oxidoreductase FOC83_16190 ENOG4105CAU Arsenical resistance protein, ArsH FOC83_16215 ENOG4105BZU Histidine kinase FOC83_16235 ENOG4105W2Z cytochrome C, class I FOC83_16240 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC83_16285 ENOG4105BZU Histidine kinase FOC83_16300 ENOG4105E18 UPF0276 protein FOC83_16335 ENOG4107QIV Cytochrome c biogenesis protein FOC83_16340 ENOG4107QX9 Thiol disulfide interChange protein FOC83_16350 ENOG4105CPK Glycosyl transferase (Group 1 FOC83_16370 ENOG4105CHH sulfate transporter FOC83_16375 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FOC83_16390 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FOC83_16400 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FOC83_16415 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC83_16420 ENOG4105CHH sulfate transporter FOC83_16495 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC83_16560 ENOG4105EAH synthase FOC83_16565 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FOC83_16570 ENOG4105K46 50S ribosomal protein l27 FOC83_16575 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC83_16580 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC83_16595 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC83_16600 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FOC83_16610 ENOG4108QBF Transcriptional regulator FOC83_16615 ENOG4105BZU Histidine kinase FOC83_16620 ENOG4105D06 uba thif-type nad fad binding protein FOC83_16625 ENOG4105CN1 protease FOC83_16630 ENOG41063SB peptidase FOC83_16635 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC83_16640 ENOG4105C72 UPF0176 protein FOC83_16645 ENOG4105VW4 glutaredoxin 3 FOC83_16650 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) FOC83_16655 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FOC83_16670 ENOG4105MJ2 Competence protein FOC83_16675 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC83_16680 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) FOC83_16685 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FOC83_16690 ENOG4105C1A potassium transporter peripheral membrane FOC83_16695 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC83_16700 ENOG4105ES5 Histidine kinase FOC83_16710 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC83_16715 ENOG410829K Lysine exporter protein (Lyse ygga) FOC83_16720 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FOC83_16730 ENOG4105KVH Transcriptional regulator FOC83_16740 ENOG4108URH decarboxylase FOC83_16750 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC83_16760 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FOC83_16765 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC83_16770 ENOG4105C79 DNA protecting protein DprA FOC83_16775 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC83_16785 ENOG4107QXX ABC transporter FOC83_16790 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC83_16795 ENOG4105DFA alanine racemase domain protein FOC83_16815 ENOG4105W39 Membrane FOC83_16820 ENOG4105C7B Threonine dehydratase FOC83_16825 ENOG4108Z9W Outer membrane porin FOC83_16835 ENOG4105EXG Transcriptional regulator FOC83_16840 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FOC83_16845 ENOG4108JJ8 (ABC) transporter FOC83_16850 ENOG4108JJ9 ABC, transporter FOC83_16860 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC83_16865 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC83_16875 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FOC83_16880 ENOG4105C2X Arabinose 5-phosphate isomerase FOC83_16885 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FOC83_16900 ENOG4108IUZ ABC transporter FOC83_16905 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FOC83_16910 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FOC83_16915 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FOC83_16920 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC83_16935 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FOC83_16945 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC83_16955 ENOG41082RQ UPF0102 protein FOC83_16960 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FOC83_16965 ENOG4105W4M Transport-associated protein FOC83_16970 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC83_16975 ENOG4105D01 (LipO)protein FOC83_16980 ENOG4105CAS nag kinase FOC83_16990 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FOC83_16995 ENOG4107QPK )-transporter FOC83_17000 ENOG4105DG4 malate L-lactate dehydrogenase FOC83_17005 ENOG4105CNI cell division protein FtsW FOC83_17010 ENOG4105CJN penicillin-binding protein FOC83_17020 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC83_17030 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FOC83_17035 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC83_17040 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FOC83_17055 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FOC83_17060 ENOG4105CGK Exodeoxyribonuclease III FOC83_17065 ENOG4105D82 Glutamate dehydrogenase FOC83_17075 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FOC83_17085 ENOG410810E transcriptional regulator, lysR family FOC83_17090 ENOG4105CP9 extracellular ligand-binding receptor FOC83_17100 ENOG4105C0Z ABC transporter FOC83_17105 ENOG4108IV0 ABC, transporter FOC83_17110 ENOG4108ZHJ Organic hydroperoxide resistance protein FOC83_17115 ENOG4105K56 Transcriptional regulator FOC83_17130 ENOG4105C0Z ABC transporter FOC83_17135 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_17150 ENOG4108IV0 ABC, transporter FOC83_17155 ENOG4105DZS Phenylacetate-CoA ligase FOC83_17175 ENOG41080HT Transcriptional regulator, arsr family FOC83_17185 ENOG4105CSR polyphosphate kinase 2 FOC83_17205 ENOG4105K78 MarR family Transcriptional regulator FOC83_17220 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase FOC83_17230 ENOG4105DWF phosphomethylpyrimidine kinase FOC83_17240 ENOG4105CFG Acts as a chaperone (By similarity) FOC83_17315 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FOC83_17320 ENOG4105C1J atp-dependent rna helicase FOC83_17330 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FOC83_17335 ENOG4107SC1 transglycosylase FOC83_17340 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC83_17370 ENOG4105SYT Methylenetetrahydrofolate reductase FOC83_17375 ENOG41086DT Membrane protein of unknown function FOC83_17380 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FOC83_17385 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FOC83_17400 ENOG4108TFY Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC83_17415 ENOG4105EJC lysr family transcriptional regulator FOC83_17425 ENOG4105CSH Transporter FOC83_17430 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC83_17435 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FOC83_17450 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FOC83_17460 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC83_17465 ENOG4105D7X high-affinity nickel-transporter FOC83_17475 ENOG4105DSE periplasmic solute binding protein FOC83_17480 ENOG4105CC5 ABC transporter FOC83_17485 ENOG4105DIK (ABC) transporter FOC83_17490 ENOG4105MYN Zinc uptake regulation protein FOC83_17495 ENOG4105CKI cobalamin synthesis protein FOC83_17505 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FOC83_17510 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FOC83_17520 ENOG4108WBT adenosyltransferase FOC83_17525 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FOC83_17540 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FOC83_17545 ENOG4108Z43 UPF0250 protein FOC83_17555 ENOG4105DZ1 carboxypeptidase FOC83_17580 ENOG4105CY3 ABC transporter, permease FOC83_17590 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FOC83_17600 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FOC83_17605 ENOG4105D16 lipopolysaccharide heptosyltransferase i FOC83_17615 ENOG4105J5G Transferase hexapeptide repeat containing protein FOC83_17620 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FOC83_17630 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FOC83_17640 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) FOC83_17665 ENOG4105CAQ asparagine synthetase FOC83_17680 ENOG4108IAJ Nad-dependent epimerase dehydratase FOC83_17690 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FOC83_17700 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FOC83_17715 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FOC83_17745 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC83_17750 ENOG4105EY8 ABC transporter FOC83_17760 ENOG4105CAQ asparagine synthetase FOC83_17780 ENOG4107Y9U Membrane FOC83_17785 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC83_17800 ENOG4105DZQ phospholipase D Transphosphatidylase FOC83_17805 ENOG4105X23 Endonuclease Exonuclease phosphatase FOC83_17810 ENOG4105C9M aspartyl-trna synthetase FOC83_17835 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC83_17850 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC83_17855 ENOG4108ZGC gaf domain protein FOC83_17860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC83_17870 ENOG4105WAY exported protein FOC83_17885 ENOG4108KWP DNA-binding transcriptional regulator GlcC FOC83_17925 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FOC83_17935 ENOG4107RDB Major Facilitator FOC83_17940 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC83_17945 ENOG4108RXX maleylacetoacetate isomerase FOC83_17950 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FOC83_17955 ENOG4105D49 3-dehydroquinate synthase FOC83_17960 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FOC83_17965 ENOG4108JQC penicillin-binding protein 1A FOC83_17970 ENOG4105XQ6 frataxin-like protein FOC83_17980 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC83_17990 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) FOC83_18000 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FOC83_18005 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC83_18015 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FOC83_18020 ENOG4105VF7 tolerance protein FOC83_18030 ENOG4108ZT0 50S ribosomal protein l17 FOC83_18035 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC83_18040 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FOC83_18045 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FOC83_18050 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FOC83_18060 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FOC83_18065 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC83_18070 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FOC83_18075 ENOG4105VPB 50S ribosomal protein L30 FOC83_18080 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FOC83_18085 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FOC83_18090 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC83_18095 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FOC83_18100 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FOC83_18105 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FOC83_18110 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FOC83_18115 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FOC83_18130 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC83_18145 ENOG4107RST alpha/beta hydrolase fold FOC83_18155 ENOG4105C0Z ABC transporter FOC83_18160 ENOG4108IV0 ABC, transporter FOC83_18165 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC83_18185 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FOC83_18190 ENOG41084PQ 50s ribosomal protein l29 FOC83_18195 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FOC83_18200 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FOC83_18205 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FOC83_18210 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FOC83_18215 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FOC83_18220 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FOC83_18230 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FOC83_18235 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FOC83_18240 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FOC83_18245 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FOC83_18250 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FOC83_18255 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FOC83_18260 ENOG4107EXC regulatoR FOC83_18275 ENOG4105BZU Histidine kinase FOC83_18290 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC83_18295 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC83_18300 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FOC83_18305 ENOG4108VZM 50s ribosomal protein L10 FOC83_18310 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FOC83_18315 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FOC83_18325 ENOG410683Z Preprotein translocase SecE subunit FOC83_18335 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FOC83_18375 ENOG4107QKW extracellular solute-binding protein family 1 FOC83_18380 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_18415 ENOG4107NQ8 LysR family Transcriptional regulator FOC83_18420 ENOG4105HDK L-asparaginase FOC83_18425 ENOG4105FA0 parb-like partition protein FOC83_18435 ENOG4107QJE Chromosome Partitioning Protein FOC83_18440 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FOC83_18445 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FOC83_18450 ENOG4105VEQ Cold shock protein FOC83_18455 ENOG4108KK1 membrane protein AbrB duplication FOC83_18460 ENOG4105CHM Aminotransferase FOC83_18505 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC83_18520 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC83_18525 ENOG4105C3U ABC transporter FOC83_18530 ENOG4108JQ7 (ABC) transporter FOC83_18535 ENOG4105CH2 amidohydrolase FOC83_18550 ENOG4105C6T cysteine synthase FOC83_18555 ENOG4105CH6 catalase FOC83_18565 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FOC83_18575 ENOG4105VG0 50S ribosomal protein l34 FOC83_18580 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FOC83_18585 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC83_18590 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC83_18595 ENOG4105CZQ inner membrane transport protein YdhC FOC83_18605 ENOG4105CC0 LysR family Transcriptional regulator FOC83_18620 ENOG4105C2I pirin domain protein FOC83_18630 ENOG4105EFZ amidohydrolase FOC83_18640 ENOG4105RQF LysR family Transcriptional regulator FOC83_18645 ENOG4107RP9 extracellular solute-binding protein, family 3 FOC83_18650 ENOG4105EAD ABC transporter FOC83_18655 ENOG4105DRP amino acid AbC transporter FOC83_18660 ENOG4105CDA abc transporter atp-binding protein FOC83_18670 ENOG4108594 Permease of the drug metabolite transporter FOC83_18695 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_18700 ENOG4105F38 ABC transporter, permease FOC83_18705 ENOG4105D38 putrescine abc transporter FOC83_18730 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FOC83_18760 ENOG4105CMD Transcriptional regulator, GntR family FOC83_18770 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_18775 ENOG4105F38 ABC transporter, permease FOC83_18780 ENOG4105D38 putrescine abc transporter FOC83_18805 ENOG4105M4H endoribonuclease L-psp FOC83_18810 ENOG4105DZC cytosine deaminase FOC83_18820 ENOG4105UIB (ABC) transporter FOC83_18825 ENOG4108JQ9 ABC transporter FOC83_18830 ENOG4107TFB basic membrane FOC83_18840 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC83_18855 ENOG4108MEJ flavin reductase domain protein FOC83_18870 ENOG4105F9N Major Facilitator Superfamily FOC83_18885 ENOG4105FFC UPF0187 protein FOC83_18890 ENOG4108YXU transcriptional regulator AsnC family FOC83_18895 ENOG4105C7K acetolactate synthase FOC83_18900 ENOG4105CHR reductase FOC83_18905 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component FOC83_18920 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC83_18930 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FOC83_18935 ENOG4108RPN Protein smg homolog FOC83_18945 ENOG4105H1G trap transporter solute receptor taxi family FOC83_18965 ENOG4105E5Q amino acid AbC transporter FOC83_18970 ENOG4105E5Q amino acid AbC transporter FOC83_18975 ENOG4106TNF Periplasmic binding protein FOC83_18980 ENOG4105KWI UPF0339 protein FOC83_18990 ENOG4105C8Y Acetylornithine aminotransferase FOC83_19015 ENOG4105VCH membrane FOC83_19025 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system FOC83_19045 ENOG4108NIW Leucine export protein LeuE FOC83_19065 ENOG4105JXH GntR family transcriptional regulator FOC83_19070 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC83_19085 ENOG4108SF5 RNA Polymerase FOC83_19090 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_19105 ENOG4105CHR reductase FOC83_19135 ENOG4105E8G Major facilitator Superfamily FOC83_19155 ENOG4107QX3 carboxylase FOC83_19160 ENOG4105CHU acetyl-coa acetyltransferase FOC83_19165 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) FOC83_19170 ENOG4105C1G acyl-Coa dehydrogenase FOC83_19175 ENOG4105CH2 amidohydrolase FOC83_19185 ENOG4105KK4 UPF0060 membrane protein FOC83_19200 ENOG410829K Lysine exporter protein (Lyse ygga) FOC83_19215 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FOC83_19225 ENOG4108Z33 Thiol disulfide Interchange Protein FOC83_19235 ENOG4105C75 arginyL-tRNA synthetase FOC83_19250 ENOG4105DRS transport system, permease FOC83_19255 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FOC83_19260 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC83_19270 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FOC83_19275 ENOG4105ETE Transcriptional regulator (LacI family FOC83_19285 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FOC83_19300 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC83_19330 ENOG4108UQY Iron-storage protein FOC83_19340 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FOC83_19345 ENOG410829K Lysine exporter protein (Lyse ygga) FOC83_19350 ENOG4105C1J atp-dependent rna helicase FOC83_19355 ENOG4106J39 exported protein FOC83_19360 ENOG4106J39 exported protein FOC83_19365 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC83_19375 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC83_19380 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC83_19385 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC83_19390 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FOC83_19395 ENOG4105KD1 integral membrane protein FOC83_19400 ENOG4105UEI Transcriptional Regulator AraC Family FOC83_19410 ENOG4107QI6 Cysteine desulfurase FOC83_19420 ENOG4105ETT transcriptional Regulator, LysR family FOC83_19435 ENOG4105C6Z Gluconate FOC83_19450 ENOG4105KB2 stringent starvation protein b FOC83_19455 ENOG4107MKT Stringent starvation protein a FOC83_19460 ENOG4105EIX cytochrome c1 FOC83_19465 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC83_19470 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC83_19475 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FOC83_19480 ENOG4107QNR UPF0135 protein FOC83_19485 ENOG4105C0H protease FOC83_19500 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FOC83_19505 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FOC83_19510 ENOG4107YU2 histidine triad (hIT) protein FOC83_19515 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase FOC83_19520 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FOC83_19525 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FOC83_19530 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FOC83_19535 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FOC83_19540 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FOC83_19545 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC83_19550 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC83_19555 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FOC83_19560 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC83_19570 ENOG4105E3A (ABC) transporter FOC83_19575 ENOG4105DA5 (ABC) transporter FOC83_19585 ENOG410903C (LipO)protein FOC83_19590 ENOG4107PE3 Mammalian cell entry related domain protein FOC83_19595 ENOG4105CY3 ABC transporter, permease FOC83_19600 ENOG4105DHJ ABC, transporter FOC83_19605 ENOG4105EA8 2-Nitropropane dioxygenase FOC83_19615 ENOG4105CBP Major Facilitator FOC83_19620 ENOG4105EGI Transcriptional regulator FOC83_19625 ENOG4105EIF outer membrane protein W FOC83_19630 ENOG4105DND Transcriptional regulator FOC83_19635 ENOG4105E7W lamb ycsf family protein FOC83_19640 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FOC83_19645 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC83_19690 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC83_19695 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FOC83_19710 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FOC83_19715 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC83_19725 ENOG4107QS1 Cytochrome C Oxidase, Subunit III FOC83_19745 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) FOC83_19775 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FOC83_19780 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC83_19785 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC83_19790 ENOG4105CG5 Glycosyl transferase (Group 1 FOC83_19820 ENOG4108SUT Major Facilitator Superfamily FOC83_19835 ENOG4105E0K tonB-dependent siderophore receptor FOC83_19840 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein FOC83_19845 ENOG4105DQ5 transport system permease protein FOC83_19850 ENOG4105TVJ transport system, permease FOC83_19855 ENOG4105E0A ABC, transporter FOC83_19875 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC83_19885 ENOG4106B0W Curli production assembly transport component CsgG FOC83_19895 ENOG4107Y60 (LipO)protein FOC83_19900 ENOG4108IYU L-aspartate oxidase FOC83_19905 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FOC83_19910 ENOG4105EQ0 Major Facilitator superfamily FOC83_19915 ENOG4105CR8 Transcriptional regulator FOC83_19925 ENOG4107QWB Ornithine cyclodeaminase FOC83_19930 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FOC83_19935 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FOC83_19940 ENOG4105EVZ LysR family transcriptional regulator FOC83_19945 ENOG4105CK7 Sodium proline symporter FOC83_19950 ENOG4105CYW agmatinase FOC83_19955 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FOC83_20010 ENOG4105CGH 5'-nucleotidase FOC83_20025 ENOG4105CZE histidine utilization repressor FOC83_20030 ENOG41090B9 response to stress FOC83_20035 ENOG4105CGP Urocanate hydratase FOC83_20040 ENOG4105ETS cytosine purines uracil thiamine allantoin FOC83_20055 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_20060 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC83_20135 ENOG4105DRR Transcriptional regulator, GntR family FOC83_20175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC83_20185 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC83_20195 ENOG4107T8P acyl-Coa dehydrogenase FOC83_20200 ENOG4107T8P acyl-Coa dehydrogenase FOC83_20210 ENOG4105D01 (LipO)protein FOC83_20215 ENOG4108UZX fmn reductase FOC83_20220 ENOG4105GVF (ABC) transporter FOC83_20225 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC83_20230 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC83_20235 ENOG4107T8P acyl-Coa dehydrogenase FOC83_20245 ENOG4108UMI ABC transporter, permease FOC83_20250 ENOG4105D01 (LipO)protein FOC83_20255 ENOG4105E2Y ABC, transporter FOC83_20260 ENOG4105X1Q TOBE domain protein FOC83_20265 ENOG4108NST exported protein FOC83_20290 ENOG4108S4H thioesterase Superfamily protein FOC83_20305 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FOC83_20310 ENOG4108MG3 formate dehydrogenase FOC83_20315 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) FOC83_20325 ENOG4105EM7 Selenocysteine-specific translation elongation factor FOC83_20335 ENOG4105K64 Glycosyl transferase, family 2 FOC83_20340 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC83_20345 ENOG4108KS2 transglutaminase domain protein FOC83_20350 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) FOC83_20360 ENOG4105ETT transcriptional Regulator, LysR family FOC83_20385 ENOG4105C26 Dehydrogenase FOC83_20390 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC83_20395 ENOG4105DK0 Indole-3-glycerol phosphate synthase FOC83_20400 ENOG4108I0Q anthranilate phosphoribosyltransferase FOC83_20405 ENOG4105DDQ anthranilate synthase FOC83_20415 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC83_20425 ENOG4105NWN ApaG protein FOC83_20435 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FOC83_20440 ENOG4105T95 Thiol disulfide interChange protein FOC83_20450 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) FOC83_20460 ENOG4105C3M thioredoxin reductase FOC83_20470 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FOC83_20480 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_20485 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_20490 ENOG4105C0Z ABC transporter FOC83_20495 ENOG4108IV0 ABC, transporter FOC83_20500 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) FOC83_20515 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein FOC83_20525 ENOG4105RE0 Asp Glu hydantoin racemase FOC83_20530 ENOG4106NZI LysR family Transcriptional regulator FOC83_20545 ENOG4107QNJ CoA-transferase subunit B FOC83_20560 ENOG4105E39 Enoyl-CoA hydratase FOC83_20575 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) FOC83_20580 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOC83_20590 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOC83_20595 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FOC83_20600 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FOC83_20610 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FOC83_20620 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC83_20625 ENOG4105C25 Primosomal protein n' FOC83_20630 ENOG4105C4R Atp-dependent dna helicase FOC83_20635 ENOG4105E7U AraC family transcriptional regulator FOC83_20645 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC83_20655 ENOG4105ECQ AraC Family Transcriptional Regulator FOC83_20660 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) FOC83_20665 ENOG4105CSR polyphosphate kinase 2 FOC83_20670 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC83_20680 ENOG4108JQ7 (ABC) transporter FOC83_20685 ENOG4105C3U ABC transporter FOC83_20700 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC83_20705 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) FOC83_20715 ENOG4105EMY transcriptional regulator FOC83_20720 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC83_20730 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FOC83_20735 ENOG41060WC Enoyl-CoA hydratase FOC83_20740 ENOG4105E39 Enoyl-CoA hydratase FOC83_20750 ENOG4105KBX Transcriptional regulator, TetR family FOC83_20765 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC83_20780 ENOG4107XZQ multidrug resistance protein FOC83_20795 ENOG4108ZHJ Organic hydroperoxide resistance protein FOC83_20800 ENOG4105EJC lysr family transcriptional regulator FOC83_20810 ENOG4108KPJ rna polymerase sigma factor FOC83_20815 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC83_20820 ENOG4108Z9W Outer membrane porin FOC83_20835 ENOG4105ERH Fumarylacetoacetate hydrolase FOC83_20845 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_20850 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC83_20855 ENOG4105C2J ABC transporter FOC83_20860 ENOG4108IV0 ABC, transporter FOC83_20870 ENOG4107XBN GntR Family Transcriptional Regulator FOC83_20880 ENOG4105DND Transcriptional regulator FOC83_20890 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) FOC83_20900 ENOG4105D9M gamma-glutamylcysteine synthetase FOC83_20930 ENOG4105DG4 malate L-lactate dehydrogenase FOC83_20935 ENOG4108JQ1 Dehydrogenase FOC83_20945 ENOG4105CTX dehydratase FOC83_20950 ENOG4105VP7 SAF domain protein FOC83_20955 ENOG4105FDP GntR family transcriptional regulator FOC83_20960 ENOG4105DWV Homoserine O-trans-acetylase FOC83_20965 ENOG4105DWV Homoserine O-trans-acetylase FOC83_20970 ENOG4105EYM Major Facilitator superfamily FOC83_20980 ENOG4105EN6 Membrane FOC83_20985 ENOG4105DRR Transcriptional regulator, GntR family FOC83_21000 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC83_21010 ENOG4107RSM transcriptional regulator FOC83_21020 ENOG4108JQ1 Dehydrogenase FOC83_21035 ENOG4105E3B Multicopper oxidase FOC83_21055 ENOG4105BZU Histidine kinase FOC83_21060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC83_21065 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC83_21080 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FOC83_21090 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FOC83_21095 ENOG4105DFG type I secretion outer membrane protein FOC83_21100 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FOC83_21105 ENOG4105DWF phosphomethylpyrimidine kinase FOC83_21110 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FOC83_21115 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FOC83_21120 ENOG4105D05 Receptor FOC83_21125 ENOG4105C3R Methionine synthase FOC83_21130 ENOG4107YCY Transcriptional regulator FOC83_21145 ENOG4105CPQ Dehydrogenase FOC83_21150 ENOG4105E5Q amino acid AbC transporter FOC83_21155 ENOG4105EAD ABC transporter FOC83_21160 ENOG4105CDA abc transporter atp-binding protein FOC83_21165 ENOG4105CXK mandelate racemase muconate lactonizing FOC83_21170 ENOG4105DEI Mannitol dehydrogenase FOC83_21185 ENOG4105CEN a g-specific adenine glycosylase FOC83_21200 ENOG4105ECQ AraC Family Transcriptional Regulator FOC83_21210 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC83_21215 ENOG4105CAK Cell division ATP-binding protein ftsE FOC83_21220 ENOG4107QXX ABC transporter FOC83_21225 ENOG4105EZ7 amino acid ABC transporter FOC83_21230 ENOG4105DRP amino acid AbC transporter FOC83_21235 ENOG4105CDA abc transporter atp-binding protein FOC83_21255 ENOG4108IV0 ABC, transporter FOC83_21260 ENOG4105C2J ABC transporter FOC83_21265 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC83_21270 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_21280 ENOG4105MSY salicylate hydroxylase FOC83_21285 ENOG4105CBX hi0933 family FOC83_21290 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC83_21295 ENOG4105CQC Prephenate dehydratase FOC83_21330 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC83_21340 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FOC83_21345 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FOC83_21350 ENOG4108Q9V regulatoR FOC83_21365 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC83_21370 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) FOC83_21375 ENOG4105ENT Efflux transporter rnd family, mfp subunit FOC83_21400 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC83_21420 ENOG4105EG2 ABC transporter, permease FOC83_21425 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FOC83_21430 ENOG4108IJ9 (ABC) transporter FOC83_21450 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC83_21470 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_21475 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC83_21480 ENOG4105C0Z ABC transporter FOC83_21485 ENOG4108IV0 ABC, transporter FOC83_21505 ENOG4105BZU Histidine kinase FOC83_21510 ENOG4105BZU Histidine kinase FOC83_21525 ENOG4108UKI Enoyl-CoA hydratase FOC83_21565 ENOG4105FUY alpha subunit FOC83_21570 ENOG4108SBK dioxygenase, subunit beta FOC83_21575 ENOG4105D3W isochorismatase FOC83_21580 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FOC83_21590 ENOG4105E4C Lytic transglycosylase catalytic FOC83_21595 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FOC83_21600 ENOG4107RZ7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FOC83_21610 ENOG4105VCQ rubredoxin FOC83_21615 ENOG4108UJU UPF0301 protein FOC83_21620 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FOC83_21630 ENOG4105CD3 dihydroorotase FOC83_21635 ENOG4108Z20 Acyl-transferase FOC83_21645 ENOG4105JSC dimethylmenaquinone methyltransferase FOC83_21655 ENOG4106PMH Extracellular solute-binding protein family 3 FOC83_21660 ENOG4105E5Q amino acid AbC transporter FOC83_21665 ENOG4105DRP amino acid AbC transporter FOC83_21670 ENOG4105CDA abc transporter atp-binding protein FOC83_21675 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC83_21685 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase FOC83_21690 ENOG4105E2X shikimate dehydrogenase FOC83_21700 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_21705 ENOG4107Z33 ABC transporter, permease FOC83_21715 ENOG4105DHQ Histidine kinase FOC83_21730 ENOG4105IPS esterase FOC83_21735 ENOG4105DFU Cell wall formation (By similarity) FOC83_21740 ENOG4107QX9 Thiol disulfide interChange protein FOC83_21745 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FOC83_21750 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FOC83_21755 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC83_21760 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FOC83_21770 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FOC83_21795 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC83_21815 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC83_21820 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC83_21830 ENOG4108YXU transcriptional regulator AsnC family FOC83_21845 ENOG4105DND Transcriptional regulator FOC83_21860 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FOC83_21865 ENOG4105CD5 CoA-binding domain protein FOC83_21870 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC83_21875 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC83_21895 ENOG4105N42 UPF0307 protein FOC83_21900 ENOG4105CMS peptidase U62, modulator of DNA gyrase FOC83_21905 ENOG4105CH5 extracellular solute-binding protein, family 7 FOC83_21920 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC83_21925 ENOG4105C0Z ABC transporter FOC83_21930 ENOG4108IV0 ABC, transporter FOC83_21935 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FOC83_21940 ENOG4108UJD 30S ribosomal protein S9 FOC83_21945 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FOC83_21955 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC83_21970 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC83_21980 ENOG410829K Lysine exporter protein (Lyse ygga) FOC83_21985 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FOC83_21990 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FOC83_22005 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC83_22020 ENOG4105CYN Serine protein kinase FOC83_22025 ENOG4106AKX UPF0229 protein FOC83_22030 ENOG4105ED1 spovr family FOC83_22040 ENOG4105ETT transcriptional Regulator, LysR family FOC83_22045 ENOG4105MDS 4-oxalocrotonate tautomerase FOC83_22055 ENOG4108Z33 Thiol disulfide Interchange Protein FOC83_22095 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC83_22100 ENOG4105JGF anti-sigma regulatory factor serine threonine protein kinase FOC83_22105 ENOG41083UI stage II sporulation protein FOC83_22120 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC83_22140 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FOC83_22145 ENOG4105E9H Lytic Murein transglycosylase FOC83_22150 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC83_22155 ENOG4105D1A Methyltransferase FOC83_22160 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOC83_22170 ENOG4105BZS acriflavin resistance protein FOC83_22175 ENOG4107RZZ dna polymerase iii epsilon subunit FOC83_22190 ENOG4108UPT UPF0178 protein FOC83_22205 ENOG4105D6U Sodium Glutamate Symporter FOC83_22220 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FOC83_22235 ENOG4105CR8 Transcriptional regulator FOC83_22255 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_22265 ENOG4108IV0 ABC, transporter FOC83_22270 ENOG4105C0Z ABC transporter FOC83_22275 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC83_22285 ENOG4105CMU LysR family (Transcriptional regulator FOC83_22290 ENOG4105VAW lrga family FOC83_22295 ENOG41067MG lrgb family FOC83_22305 ENOG4105T38 integral membrane protein FOC83_22310 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC83_22325 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FOC83_22335 ENOG4108YXU transcriptional regulator AsnC family FOC83_22350 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FOC83_22355 ENOG4105EHG Permease protein FOC83_22365 ENOG4105KCK Peptidoglycan-associated lipoprotein FOC83_22370 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FOC83_22385 ENOG4105E02 MotA TolQ exbB proton channel FOC83_22390 ENOG4107YD3 Thioesterase FOC83_22395 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FOC83_22425 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FOC83_22430 ENOG4105EXG Transcriptional regulator FOC83_22440 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC83_22445 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC83_22485 ENOG4105C01 Dihydroxy-acid dehydratase FOC83_22490 ENOG4105W2Z cytochrome C, class I FOC83_22495 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC83_22505 ENOG4105EW9 transcriptional regulator AsnC family FOC83_22545 ENOG4105ETT transcriptional Regulator, LysR family FOC83_22555 ENOG4105CH2 amidohydrolase FOC83_22560 ENOG4105EKE dihydroorotase FOC83_22565 ENOG4105C5H ABC transporter FOC83_22575 ENOG4108V6E Cell division protein mraZ FOC83_22580 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FOC83_22585 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FOC83_22590 ENOG4105CJN penicillin-binding protein FOC83_22595 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC83_22600 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FOC83_22605 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FOC83_22615 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC83_22620 ENOG4105DFU Cell wall formation (By similarity) FOC83_22625 ENOG4105CPF Cell wall formation (By similarity) FOC83_22630 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FOC83_22635 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC83_22640 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC83_22645 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FOC83_22655 ENOG4105DR5 peptidase FOC83_22660 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC83_22680 ENOG4105C7K acetolactate synthase FOC83_22695 ENOG4108XM1 transcriptional regulator AsnC family FOC83_22710 ENOG4105CJW magnesium transporter FOC83_22715 ENOG4105NAU thioesterase Superfamily protein FOC83_22720 ENOG4105HMI Membrane FOC83_22730 ENOG4105CH2 amidohydrolase FOC83_22735 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_22740 ENOG4105ECY inositol monophosphatase FOC83_22745 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FOC83_22750 ENOG4105CJQ hydrolase, family 31 FOC83_22755 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC83_22760 ENOG4108UMI ABC transporter, permease FOC83_22765 ENOG4105D01 (LipO)protein FOC83_22775 ENOG4108SF5 RNA Polymerase FOC83_22780 ENOG4108S3W Anti-feci sigma factor, fecr FOC83_22800 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_22805 ENOG4106P55 Transcriptional regulator FOC83_22815 ENOG41090R7 Ferric uptake FOC83_22840 ENOG4108R3E Dna-3-methyladenine glycosylase i FOC83_22845 ENOG4105E0M Sulfatase FOC83_22850 ENOG41066T0 asmA family FOC83_22865 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FOC83_22900 ENOG4105KZX Pterin carbinolamine dehydratase FOC83_22915 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase FOC83_22925 ENOG4108S0S Nucleotidyl transferase FOC83_22930 ENOG4105EHM Aminoglycoside phosphotransferase FOC83_22940 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FOC83_22945 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FOC83_22950 ENOG4105BZW Glycerate kinase FOC83_22955 ENOG4105CA9 Pyruvate kinase FOC83_22965 ENOG4107QPN acyl-Coa dehydrogenase FOC83_22970 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC83_22990 ENOG4105E9Q Acyl-transferase FOC83_22995 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC83_23000 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FOC83_23005 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FOC83_23020 ENOG4107SDU Methyl-accepting chemotaxis FOC83_23030 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC83_23040 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FOC83_23055 ENOG4105EA8 2-Nitropropane dioxygenase FOC83_23065 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_23070 ENOG4105CHU acetyl-coa acetyltransferase FOC83_23080 ENOG4105CC9 acyl-Coa dehydrogenase FOC83_23085 ENOG4105C1G acyl-Coa dehydrogenase FOC83_23090 ENOG4108UKI Enoyl-CoA hydratase FOC83_23100 ENOG4108M9J MaoC like domain protein FOC83_23110 ENOG4105CI0 Citrate lyase FOC83_23115 ENOG4108MGF sugar kinase FOC83_23120 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC83_23125 ENOG4105DJ0 Poly(A) Polymerase FOC83_23135 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) FOC83_23140 ENOG4105CXB phosphoribosylaminoimidazole synthetase FOC83_23150 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FOC83_23155 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FOC83_23160 ENOG4105DQR SNARE associated Golgi FOC83_23170 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC83_23175 ENOG4105K8N protein family UPF0079, ATPase FOC83_23180 ENOG4105C9Q fumarate hydratase class II FOC83_23195 ENOG4105DUM transcriptional regulator, lysR family FOC83_23200 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC83_23205 ENOG4105CUB amino acid FOC83_23210 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC83_23220 ENOG4105CSU acyl-Coa dehydrogenase FOC83_23225 ENOG4107RSM transcriptional regulator FOC83_23230 ENOG4105ERH Fumarylacetoacetate hydrolase FOC83_23240 ENOG4105DMF Dehydrogenase FOC83_23260 ENOG4105CR8 Transcriptional regulator FOC83_23270 ENOG4105D5U fad dependent oxidoreductase FOC83_23280 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FOC83_23295 ENOG4105DJY efflux transporter, rnd family, mfp subunit FOC83_23300 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC83_23305 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC83_23310 ENOG4106NZI LysR family Transcriptional regulator FOC83_23330 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC83_23360 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC83_23370 ENOG4105CW7 secretion protein, HlyD family FOC83_23375 ENOG4105CUZ uba thif-type nad fad binding protein FOC83_23415 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC83_23425 ENOG4108UHU Aldolase FOC83_23440 ENOG4105K64 Glycosyl transferase, family 2 FOC83_23445 ENOG4108IV0 ABC, transporter FOC83_23450 ENOG4105C0Z ABC transporter FOC83_23465 ENOG4105CHR reductase FOC83_23470 ENOG4106IPI cyclase, family FOC83_23485 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_23490 ENOG4108UKV benzoate 1,2-dioxygenase FOC83_23495 ENOG4105FUY alpha subunit FOC83_23520 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC83_23525 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC83_23530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC83_23535 ENOG4105C3U ABC transporter FOC83_23540 ENOG4108JQ7 (ABC) transporter FOC83_23560 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC83_23565 ENOG4105C5H ABC transporter FOC83_23590 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FOC83_23595 ENOG4107QMS site-determining protein FOC83_23600 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FOC83_23605 ENOG4105CX6 glutaminyL-tRNA synthetase FOC83_23615 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC83_23620 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC83_23640 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FOC83_23650 ENOG4105ECP epimerase FOC83_23655 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FOC83_23675 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC83_23680 ENOG4105D0A hydroxylase FOC83_23690 ENOG4107RAQ aminopeptidase FOC83_23705 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FOC83_23710 ENOG4108Z9W Outer membrane porin FOC83_23725 ENOG4105ERG peptidase m48, ste24p FOC83_23745 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC83_23765 ENOG4105EYM Major Facilitator superfamily FOC83_23770 ENOG4107ZSV Receptor FOC83_23780 ENOG4105C1J atp-dependent rna helicase FOC83_23795 ENOG4107TH8 cina domain protein FOC83_23800 ENOG41069M3 Transcriptional regulator FOC83_23815 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FOC83_23820 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate FOC83_23825 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FOC83_23915 ENOG4107YH6 single-stranded DNA-binding protein FOC83_23920 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC83_23935 ENOG4105W1Y Transcriptional regulator FOC83_23945 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FOC83_24060 ENOG4105EKQ RNA-directed DNA polymerase FOC83_24085 ENOG4105EKQ RNA-directed DNA polymerase FOC83_24190 ENOG4105VT3 DNA binding domain protein, excisionase family FOC83_24305 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FOC83_24320 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC83_24340 ENOG4105DJ2 Major Facilitator Superfamily FOC83_24355 ENOG4107ZSV Receptor FOC83_24385 ENOG4105CIG ABC transporter FOC83_24390 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FOC83_24405 ENOG4107QI1 Mate efflux family protein FOC83_24410 ENOG4105E45 Histidinol-phosphate aminotransferase FOC83_24465 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression FOC83_24485 ENOG4108V62 Rhodanese domain protein FOC83_24490 ENOG41080HT Transcriptional regulator, arsr family FOC83_24520 ENOG4107ZSV Receptor FOC83_24535 ENOG4105EYM Major Facilitator superfamily FOC83_24540 ENOG4105WPR Transcriptional regulator, ARAC family FOC83_24545 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FOC83_24560 ENOG4108JJ6 Type I secretion system ATPase FOC83_24575 ENOG4107QZV Type I secretion membrane fusion protein FOC83_24580 ENOG4105DFG type I secretion outer membrane protein FOC83_24585 ENOG4105C0W non-ribosomal peptide synthetase FOC83_24605 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC83_24615 ENOG4106NZI LysR family Transcriptional regulator FOC83_24645 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FOC83_24650 ENOG41090R7 Ferric uptake FOC83_24655 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC83_24665 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FOC83_24670 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC83_24680 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC83_24690 ENOG4105CFG Acts as a chaperone (By similarity) FOC83_24695 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOC83_24710 ENOG4108YYQ gCN5-related N-acetyltransferase FOC83_24730 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC83_24765 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_24770 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC83_24785 ENOG4105EEX Two component transcriptional regulator (Winged helix family FOC83_24790 ENOG4105C08 Histidine kinase FOC83_24795 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FOC83_24800 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FOC83_24805 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FOC83_24820 ENOG4107QN1 sodium solute FOC83_24830 ENOG4105C98 muts2 protein FOC83_24835 ENOG4105C3M thioredoxin reductase FOC83_24840 ENOG4105CNU cell division protein FtsK FOC83_24845 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FOC83_24850 ENOG4105KME endoribonuclease L-psp FOC83_24860 ENOG4105C2X Arabinose 5-phosphate isomerase FOC83_24900 ENOG4105D1H recombination factor protein RarA FOC83_24905 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FOC83_24940 ENOG4105DIA mandelate racemase muconate lactonizing FOC83_24945 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC83_24965 ENOG4108IPW abc transporter atp-binding protein FOC83_25005 ENOG4105DTD Dehydrogenase FOC83_25010 ENOG4105D1Q UPF0246 protein FOC83_25020 ENOG4105C7K acetolactate synthase FOC83_25025 ENOG4108ZP8 Acetolactate synthase small subunit FOC83_25030 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC83_25035 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC83_25045 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FOC83_25050 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FOC83_25060 ENOG4105C7B Threonine dehydratase FOC83_25070 ENOG4105ES4 Nitrilase FOC83_25080 ENOG4105E7U AraC family transcriptional regulator FOC83_25105 ENOG4105CP7 Triose-phosphate isomerase FOC83_25110 ENOG4105NTZ Preprotein translocase subunit SecG FOC83_25150 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_25170 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC83_25205 ENOG4108NFJ ABC transporter FOC83_25220 ENOG4108SF5 RNA Polymerase FOC83_25225 ENOG4108S3W Anti-feci sigma factor, fecr FOC83_25245 ENOG4105ECM Sensor protein basS pmrB FOC83_25255 ENOG4105D4T Citrate transporter FOC83_25260 ENOG4105CHR reductase FOC83_25280 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC83_25285 ENOG4105CQZ Histidine kinase FOC83_25305 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC83_25310 ENOG4105XDF Protein of unknown function (DUF1272) FOC83_25315 ENOG4105CKW Inner membrane protein yedI FOC83_25320 ENOG4105GAV receptor FOC83_25345 ENOG4108JQ6 ABC transporter FOC83_25355 ENOG4106R87 Extracellular solute-binding protein, family 5 FOC83_25375 ENOG4105BZS acriflavin resistance protein FOC83_25380 ENOG4105ENT Efflux transporter rnd family, mfp subunit FOC83_25390 ENOG4105C94 Transporter FOC83_25395 ENOG4105ENT Efflux transporter rnd family, mfp subunit FOC83_25400 ENOG4105BZS acriflavin resistance protein FOC83_25415 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC83_25420 ENOG4105BZS acriflavin resistance protein FOC83_25425 ENOG4105C1P efflux transporter, rnd family, mfp subunit FOC83_25430 ENOG4108IG5 Transcriptional regulator FOC83_25435 ENOG4108R4R Iron-regulated virulence regulatory protein FOC83_25455 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FOC83_25480 ENOG4108Z9W Outer membrane porin FOC83_25485 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC83_25490 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC83_25495 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC83_25500 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC83_25515 ENOG4108IEH NADH dehydrogenase subunit g FOC83_25520 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FOC83_25525 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC83_25530 ENOG4105DF2 NADH dehydrogenase subunit j FOC83_25535 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC83_25545 ENOG4105C8S subunit m FOC83_25550 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC83_25560 ENOG4108ESX Receptor FOC83_25565 ENOG4108ESX Receptor FOC83_25570 ENOG4105EAC phosphoserine phosphatase FOC83_25575 ENOG4108JA2 transcriptioN-repair coupling factor FOC83_25580 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FOC83_25585 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FOC83_25595 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FOC83_25600 ENOG4105D3R alkyl hydroperoxide reductase FOC83_25605 ENOG4105E0F Histidine kinase FOC83_25615 ENOG41072GX Peptidase M22 Glycoprotease FOC83_25620 ENOG4108UN4 phage SPO1 DNA polymerase-related protein FOC83_25625 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FOC83_25630 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC83_25640 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FOC83_25645 ENOG4107TF3 peptidylprolyl cis-trans isomerase FOC83_25655 ENOG4107835 probably involved in intracellular septation (By similarity) FOC83_25660 ENOG4105E0X reductase FOC83_25665 ENOG4108JJB ABC transporter FOC83_25670 ENOG4107QCX Transporter FOC83_25675 ENOG4107ZYJ bioY protein FOC83_25690 ENOG4105C0Z ABC transporter FOC83_25695 ENOG4108IV0 ABC, transporter FOC83_25705 ENOG4105HSS phospholipase C FOC83_25725 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_25735 ENOG4108IV0 ABC, transporter FOC83_25740 ENOG4105C0Z ABC transporter FOC83_25745 ENOG4105CSM endonuclease III FOC83_25750 ENOG4108R3D Electron transport complex FOC83_25760 ENOG4105DP0 ferredoxin-NADP reductase FOC83_25765 ENOG4108Z4U Ferredoxin FOC83_25770 ENOG4107RH7 Nicotinate phosphoribosyltransferase FOC83_25775 ENOG4105M4H endoribonuclease L-psp FOC83_25785 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) FOC83_25790 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC83_25795 ENOG4105CSH Transporter FOC83_25800 ENOG4105CWC Acetylornithine deacetylase FOC83_25810 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FOC83_25815 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FOC83_25820 ENOG41061N2 exported protein FOC83_25825 ENOG4107QQB Ribonuclease E FOC83_25830 ENOG4105EI2 Pseudouridine synthase FOC83_25835 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC83_25840 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FOC83_25845 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) FOC83_25855 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC83_25860 ENOG4108UHJ MAF-like protein FOC83_25865 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FOC83_25870 ENOG4105VGS 50s ribosomal protein l32 FOC83_25880 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC83_25885 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC83_25890 ENOG4105CHR reductase FOC83_25895 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FOC83_25900 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC83_25910 ENOG4105EMN RNA polymerase sigma factor FOC83_25925 ENOG4105C0H protease FOC83_25930 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FOC83_25935 ENOG4105C3F Signal peptidase i FOC83_25940 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FOC83_25945 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC83_25950 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FOC83_26000 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FOC83_26010 ENOG4108MP6 LysR family Transcriptional regulator FOC83_26020 ENOG4105C26 Dehydrogenase FOC83_26025 ENOG4107R11 Transcriptional regulator FOC83_26035 ENOG4105K4H Nlp p60 protein FOC83_26040 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC83_26045 ENOG4108ZJF Glcg protein FOC83_26060 ENOG4108Q5Y Membrane FOC83_26065 ENOG4105C5W Aldolase FOC83_26070 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC83_26090 ENOG4107SRH Nad-dependent epimerase dehydratase FOC83_26095 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FOC83_26115 ENOG4107YB6 acetyltransferase, (GNAT) family FOC83_26125 ENOG4105D44 asparaginase FOC83_26130 ENOG4108JQ6 ABC transporter FOC83_26135 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC83_26170 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FOC83_26180 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FOC83_26195 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FOC83_26205 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC83_26235 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC83_26240 ENOG4108YXA Membrane FOC83_26245 ENOG4105DXD 2-methylcitrate dehydratase FOC83_26250 ENOG4105BZN citrate synthase FOC83_26255 ENOG4105CR4 methylisocitrate lyase FOC83_26260 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC83_26265 ENOG4105FDP GntR family transcriptional regulator FOC83_26270 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FOC83_26275 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FOC83_26285 ENOG4105E33 succinate dehydrogenase FOC83_26290 ENOG41060IS Flavinator of succinate dehydrogenase FOC83_26295 ENOG4105BZN citrate synthase FOC83_26310 ENOG4105C6K Malic enzyme FOC83_26315 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FOC83_26320 ENOG4105EPD Oligopeptide transporter, Opt family FOC83_26325 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FOC83_26340 ENOG4105K6H D-cysteine desulfhydrase FOC83_26345 ENOG4108XM1 transcriptional regulator AsnC family FOC83_26350 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FOC83_26355 ENOG4105C7S Dehydrogenase FOC83_26360 ENOG4107QN2 dihydrolipoyl dehydrogenase FOC83_26365 ENOG4105D6Z AFG1 family ATPase FOC83_26370 ENOG4108SF5 RNA Polymerase FOC83_26375 ENOG4108S3W Anti-feci sigma factor, fecr FOC83_26380 ENOG4105E0K tonB-dependent siderophore receptor FOC83_26415 ENOG4105BZM domain protein FOC83_26420 ENOG4105DVT helicase FOC83_26425 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FOC83_26430 ENOG4105C34 Pseudouridine synthase FOC83_26435 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC83_26440 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class FOC83_26445 ENOG4105CHR reductase FOC83_26450 ENOG4108NVM synthesis repressor PhaR FOC83_26475 ENOG4105D5K Hemolysin activator protein FOC83_26500 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC83_26505 ENOG4105K3G Periplasmic Protein FOC83_26515 ENOG4105VDW Csbd family FOC83_26530 ENOG4105BZ1 (ABC) transporter FOC83_26545 ENOG4105ED9 Protein of unknown function (DUF455) FOC83_26550 ENOG4108RPX mosc domain containing protein FOC83_26555 ENOG4105CVE Lytic murein transglycosylase FOC83_26570 ENOG4105C1G acyl-Coa dehydrogenase FOC83_26580 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) FOC83_26590 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC83_26600 ENOG4108XTA Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate FOC83_26610 ENOG410802X bacteriophage n4 adsorption protein b FOC83_26620 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC83_26635 ENOG4105F27 Major Facilitator FOC83_26640 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC83_26645 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC83_26650 ENOG4105UYK outer membrane protein a FOC83_26655 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC83_26660 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FOC83_26665 ENOG4105CQC Prephenate dehydratase FOC83_26680 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FOC83_26685 ENOG4105CAT Cytidine monophosphate kinase FOC83_26690 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FOC83_26705 ENOG4105CFV Tetratricopeptide repeat protein FOC83_26710 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FOC83_26715 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FOC83_26725 ENOG4105C6T cysteine synthase FOC83_26745 ENOG4105CVE Lytic murein transglycosylase FOC83_26755 ENOG4105BZJ Electron transfer flavoprotein FOC83_26760 ENOG4105C10 Electron transfer flavoprotein FOC83_26780 ENOG4105CSU acyl-Coa dehydrogenase FOC83_26785 ENOG4105D3R alkyl hydroperoxide reductase FOC83_26790 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FOC83_26795 ENOG4108I5D sulfate abc transporter FOC83_26820 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FOC83_26840 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FOC83_26845 ENOG4105P8F nudix hydrolase FOC83_26850 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC83_26855 ENOG4105D0M Protease HtpX homolog FOC83_26860 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FOC83_26870 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FOC83_26875 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FOC83_26880 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FOC83_26885 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FOC83_26890 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FOC83_26895 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC83_26905 ENOG4108UKI Enoyl-CoA hydratase FOC83_26910 ENOG4108ZJI phenylacetic acid degradation protein FOC83_26920 ENOG4107QI1 Mate efflux family protein FOC83_26935 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOC83_26940 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC83_26945 ENOG4105W5Q DNA repair protein (RadC FOC83_26955 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FOC83_26960 ENOG4108RXX maleylacetoacetate isomerase FOC83_26965 ENOG4105C0H protease FOC83_26970 ENOG4105DHQ Histidine kinase FOC83_26975 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC83_26990 ENOG4105CKI cobalamin synthesis protein FOC83_26995 ENOG4105CKI cobalamin synthesis protein FOC83_27000 ENOG4105EJC lysr family transcriptional regulator FOC83_27015 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FOC83_27020 ENOG4105FE9 pseudouridine synthase FOC83_27025 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FOC83_27030 ENOG4105CHV Transcription elongation factor NusA FOC83_27035 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FOC83_27040 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FOC83_27045 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC83_27050 ENOG4105CI3 gtp-binding protein typa FOC83_27075 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B FOC83_27080 ENOG4108URH decarboxylase FOC83_27085 ENOG4105C2M dna polymerase I FOC83_27095 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FOC83_27100 ENOG4105EAM Na Pi-cotransporter FOC83_27105 ENOG4105EJQ L-serine dehydratase FOC83_27110 ENOG4105D0M Protease HtpX homolog FOC83_27120 ENOG4105KHC sulfurtransferase FOC83_27130 ENOG4105DUM transcriptional regulator, lysR family FOC83_27135 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_27145 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOC83_27180 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FOC83_27185 ENOG4105CTB Polyprenyl synthetase FOC83_27195 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) FOC83_27200 ENOG4105NX3 Membrane FOC83_27205 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FOC83_27215 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FOC83_27220 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FOC83_27230 ENOG4105CDU Replicative dna helicase FOC83_27235 ENOG4105DHU Bile acid FOC83_27240 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FOC83_27250 ENOG4105EW9 transcriptional regulator AsnC family FOC83_27275 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC83_27325 ENOG4105CXT aspartate transcarbamylase FOC83_27345 ENOG4105CSH Transporter FOC83_27350 ENOG4105DHQ Histidine kinase FOC83_27360 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FOC83_27365 ENOG4108004 Modulates RecA activity (By similarity) FOC83_27370 ENOG4105DZ2 Transcriptional regulator FOC83_27390 ENOG4105CMV Succinyl-CoA synthetase subunit beta FOC83_27395 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC83_27400 ENOG4108ZCF integral membrane protein FOC83_27405 ENOG4108ZCF integral membrane protein FOC83_27410 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FOC83_27430 ENOG4105F0N pyrophosphate phospho-hydrolase FOC83_27455 ENOG4105CHR reductase FOC83_27460 ENOG4105C0Z ABC transporter FOC83_27465 ENOG4108IV0 ABC, transporter FOC83_27470 ENOG4105C32 Amino acid ABC transporter (Permease) FOC83_27490 ENOG4108IAB Phoh family FOC83_27495 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC83_27505 ENOG4105CHM Aminotransferase FOC83_27510 ENOG4105D6E homoserine dehydrogenase FOC83_27525 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 FOC83_27530 ENOG4105CD8 aminopeptidase N FOC83_27540 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS FOC83_27545 ENOG4105D1U peptidase U62 modulator of DNA gyrase FOC83_27550 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FOC83_27555 ENOG4105CQB FAD linked oxidase domain protein FOC83_27560 ENOG4105CQB FAD linked oxidase domain protein FOC83_27565 ENOG4105EU8 FAD linked oxidase domain protein FOC83_27570 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC83_27575 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FOC83_27580 ENOG4105W8H transhydrogenase (subunit alpha FOC83_27585 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FOC83_27600 ENOG4105ETT transcriptional Regulator, LysR family FOC83_27605 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC83_27610 ENOG4105HF0 Membrane FOC83_27615 ENOG4108U78 Glutathione S-transferase FOC83_27620 ENOG4107QTF adenylosuccinate lyase FOC83_27625 ENOG4105T86 cytochrome C FOC83_27655 ENOG4108REF Sporulation integral membrane protein ytvi FOC83_27665 ENOG4108MAJ Membrane FOC83_27770 ENOG4105BZU Histidine kinase FOC83_27780 ENOG4105RPH Inner membrane protein YddG FOC83_27815 ENOG41067HS methyltransferase FOC83_27825 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC83_27830 ENOG4105CBC glutamate synthase FOC83_27835 ENOG41066VF YeeE YedE family protein FOC83_27840 ENOG4105RK9 auxin efflux carrier FOC83_27850 ENOG4108HPG -acetyltransferase FOC83_27870 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC83_27875 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC83_27880 ENOG4105C28 cystathionine FOC83_27885 ENOG4107E2E PKHD-type hydroxylase FOC83_27890 ENOG4105K70 DNA-binding protein FOC83_27915 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC83_27920 ENOG4105DHQ Histidine kinase FOC83_27925 ENOG4105DFH Transport of potassium into the cell (By similarity) FOC83_27930 ENOG4105CDH Citrulline--aspartate ligase FOC83_27935 ENOG4105C5Q Transcriptional regulator FOC83_27940 ENOG4105GAK amidohydrolase 2 FOC83_27960 ENOG4108XEP Alpha Beta Hydrolase Fold protein FOC83_27965 ENOG4105DBV ornithine carbamoyltransferase FOC83_27970 ENOG4105C8Y Acetylornithine aminotransferase FOC83_27980 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC83_27990 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FOC83_27995 ENOG4105CV6 ABC transporter, permease FOC83_28005 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) FOC83_28015 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC83_28020 ENOG4105F38 ABC transporter, permease FOC83_28025 ENOG4105D38 putrescine abc transporter FOC83_28035 ENOG4108RB4 3-methyladenine DNA glycosylase FOC83_28045 ENOG4107QSV RmuC domain protein FOC83_28055 ENOG4105CSU acyl-Coa dehydrogenase FOC83_28065 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC83_28070 ENOG4105HSS phospholipase C FOC83_28075 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) FOC83_28080 ENOG4108EKC n-acetylglutamate synthase FOC83_28085 ENOG4105CQ7 ATP-dependent helicase FOC83_28090 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FOC83_28105 ENOG4105C0B DNA polymerase III (alpha subunit) FOC83_28110 ENOG4105CPK Glycosyl transferase (Group 1 FOC83_28115 ENOG4107BJW polysaccharide deacetylase FOC83_28120 ENOG4106WTF Glycosyl transferase, family 2 FOC83_28125 ENOG4107T8Q Glycosyl transferase (Group 1 FOC83_28130 ENOG4107BJW polysaccharide deacetylase FOC83_28140 ENOG4105KRS Proteinase inhibitor FOC83_28155 ENOG4105BZ1 (ABC) transporter FOC83_28160 ENOG4105CKD glutathione-regulated potassium-efflux system protein FOC83_28175 ENOG4106JH6 (LipO)protein FOC83_28180 ENOG4105C03 ribonuclease FOC83_28210 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC83_28220 ENOG4105CK2 sodium dicarboxylate symporter FOC83_28230 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FOC83_28235 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FOC83_28240 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FOC83_28250 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC83_28255 ENOG4105CDY transcriptional regulatory protein FOC83_28260 ENOG4105D7A ATP-binding protein FOC83_28265 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC83_28275 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC83_28280 ENOG4105CW7 secretion protein, HlyD family FOC83_28290 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FOC83_28305 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC83_28350 ENOG4105WPN DNA integration recombination invertion protein FOC83_28355 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FOC83_28365 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC83_28370 ENOG4105K63 Thioredoxin FOC83_28375 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC83_28385 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC83_28390 ENOG4108R86 Transcriptional regulator FOC83_28400 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC83_28425 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) FOC83_28430 ENOG4105EV8 ectoine hydroxylase FOC83_28435 ENOG4105QVC MOSC domain-containing protein FOC83_28440 ENOG4105KPY Small multidrug resistance protein FOC83_28455 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC83_28470 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC83_28475 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FOC83_28485 ENOG4105K5M 30s ribosomal protein S16 FOC83_28495 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FOC83_28500 ENOG4105WBV Transcriptional regulator FOC83_28505 ENOG4106TNF Periplasmic binding protein FOC83_28510 ENOG4105E5Q amino acid AbC transporter FOC83_28515 ENOG4105CDA abc transporter atp-binding protein FOC83_28520 ENOG4105CJP fad dependent oxidoreductase FOC83_28525 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC83_28530 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FOC83_28555 ENOG4105N21 Membrane FOC83_28560 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FOC83_28565 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FOC83_28570 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC83_28575 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC83_28580 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC83_28585 ENOG4107QJR hflk protein FOC83_28590 ENOG4105EPW hflc protein FOC83_28595 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FOC83_28600 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOC83_28605 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) FOC83_28610 ENOG4105VCC 30S ribosomal protein S21 FOC83_28620 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC83_28630 ENOG4105CPK Glycosyl transferase (Group 1 FOC83_28640 ENOG4105EXC Acyl-transferase FOC83_28700 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC83_28710 ENOG4107S2Z UPF0761 membrane protein FOC83_28720 ENOG4105CNG UPF0061 protein FOC83_28740 ENOG4105BZU Histidine kinase FOC83_28745 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC83_28750 ENOG4105ERG peptidase m48, ste24p FOC83_28845 ENOG4108JJA ABC, transporter FOC83_28855 ENOG4105DFG type I secretion outer membrane protein FOC83_28875 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC83_28885 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC83_28890 ENOG4105CH5 extracellular solute-binding protein, family 7 FOC83_28910 ENOG4105CPT Alpha beta hydrolase FOC83_28950 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FOC83_28955 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC83_28960 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter FOC83_28965 ENOG4105DIQ Transcriptional regulator FOC83_28970 ENOG4105FR1 rard protein FOC83_28980 ENOG4105K8K Cupin 2, conserved barrel FOC83_28985 ENOG4108JQ6 ABC transporter FOC83_28990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC83_28995 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC83_29005 ENOG4105C26 Dehydrogenase FOC83_29010 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FOC83_29035 ENOG4105D4P Coproporphyrinogen iii oxidase FOC83_29040 ENOG41068CG regulatoR FOC83_29045 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC83_29050 ENOG4105C22 threonyL-tRNA synthetase FOC83_29055 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC83_29070 ENOG41080Z8 PHOSPHOCARRIER protein FOC83_29075 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC83_29080 ENOG4105BZU Histidine kinase FOC83_29085 ENOG4108YZA Nitrogen regulatory protein pii FOC83_29095 ENOG4105W0Z cytoplasmic protein FOC83_29100 ENOG4105C0P Mg chelatase subunit ChlI FOC83_29105 ENOG4105VJV 50s ribosomal protein L35 FOC83_29110 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FOC83_29115 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FOC83_29120 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC83_29180 ENOG4108R6G acetyltransferase FOC83_29215 ENOG4108YXU transcriptional regulator AsnC family FOC83_29275 ENOG4105E2Y ABC, transporter FOC83_29290 ENOG4105C5Q Transcriptional regulator FOC83_29295 ENOG4105DHU Bile acid FOC83_29305 ENOG4108JJ7 ABC transporter FOC83_29310 ENOG4105CV8 reductase FOC83_29325 ENOG4108R1E Serine threonine protein phosphatase 1 FOC83_29330 ENOG4108JQC penicillin-binding protein 1A FOC83_29335 ENOG4105ID8 Transcriptional regulator, ARAC family FOC83_29340 ENOG4105EU0 Major facilitator Superfamily FOC83_29350 ENOG4105CND Glycosyl transferase, family 2 FOC83_29355 ENOG4107BJW polysaccharide deacetylase FOC83_29360 ENOG4108TUY outer membrane protein PgaA FOC83_29365 ENOG4105BZU Histidine kinase FOC83_29385 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC83_29390 ENOG4105KTH gatB Yqey FOC83_29395 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC83_29400 ENOG4105C2D reductase FOC83_29440 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FOC83_29455 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FOC83_29480 ENOG4105KPV Transcriptional regulator FOC83_29485 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC83_29490 ENOG4105SX7 Transporter FOC83_29495 ENOG41062BK proline dehydrogenase FOC83_29520 ENOG4105CBN LysR family transcriptional regulator FOC83_29545 ENOG4108IY8 ABC, transporter FOC83_29560 ENOG4105CSU acyl-Coa dehydrogenase FOC83_29565 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_29585 ENOG4105DSQ Nitric oxide reductase FOC83_29605 ENOG4105MPD Cytochrome FOC83_29610 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FOC83_29615 ENOG4105DC8 reductase FOC83_29625 ENOG4105N14 lysine exporter protein LysE YggA FOC83_29640 ENOG4108Q5Y Membrane FOC83_29660 ENOG4107QI1 Mate efflux family protein FOC83_29665 ENOG4108IPT Naphthoate synthase FOC83_29670 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC83_29680 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC83_29685 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) FOC83_29695 ENOG4105CHR reductase FOC83_29730 ENOG4108K3Z AraC family transcriptional regulator FOC83_29745 ENOG4107JEE Short-chain dehydrogenase reductase Sdr FOC83_29755 ENOG4108JQ1 Dehydrogenase FOC83_29760 ENOG4105JSC dimethylmenaquinone methyltransferase FOC83_29770 ENOG4105DMF Dehydrogenase FOC83_29785 ENOG4105CNM Receptor FOC83_29790 ENOG4108S3W Anti-feci sigma factor, fecr FOC83_29795 ENOG4108SF5 RNA Polymerase FOC83_29825 ENOG4105GQR Chaperone FOC83_29835 ENOG4105BZU Histidine kinase FOC83_29840 ENOG4105BZU Histidine kinase FOC83_29860 ENOG4105EUB pirin domain protein FOC83_29875 ENOG4105KWW Biogenesis protein FOC83_29880 ENOG4107QX9 Thiol disulfide interChange protein FOC83_29885 ENOG4105DA4 cytochrome c-type biogenesis protein FOC83_29890 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) FOC83_29900 ENOG41060IM Heme exporter protein FOC83_29905 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FOC83_29910 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) FOC83_29930 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) FOC83_29935 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FOC83_29940 ENOG4106WHD Tetrathionate reductase FOC83_29945 ENOG4105DB1 molybdopterin oxidoreductase FOC83_29950 ENOG4108M1T Cytochrome c-type biogenesis protein FOC83_29955 ENOG4105KWW Biogenesis protein FOC83_29960 ENOG4107QX9 Thiol disulfide interChange protein FOC83_29965 ENOG4105DA4 cytochrome c-type biogenesis protein FOC83_29980 ENOG41060IM Heme exporter protein FOC83_29985 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FOC83_29990 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) FOC83_30025 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC83_30030 ENOG4107RSM transcriptional regulator FOC83_30040 ENOG4105C01 Dihydroxy-acid dehydratase FOC83_30050 ENOG4105BZU Histidine kinase FOC83_30055 ENOG4105E39 Enoyl-CoA hydratase FOC83_30095 ENOG4107S01 Repressor protein MetJ FOC83_30105 ENOG4105CBN LysR family transcriptional regulator FOC83_30110 ENOG4105CY2 Citrate transporter FOC83_30130 ENOG4105E09 nadh pyrophosphatase FOC83_30150 ENOG4108S8N class II Aldolase FOC83_30155 ENOG4105CSH Transporter FOC83_30175 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_30190 ENOG4105CHR reductase FOC83_30210 ENOG4105EW9 transcriptional regulator AsnC family FOC83_30215 ENOG4105CCF Lysine exporter protein (Lyse ygga) FOC83_30220 ENOG4108JJ7 ABC transporter FOC83_30225 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC83_30245 ENOG4105CEY Amp-dependent synthetase and ligase FOC83_30250 ENOG4105CHR reductase FOC83_30280 ENOG4105BZ1 (ABC) transporter FOC83_30285 ENOG4105ETT transcriptional Regulator, LysR family FOC83_30295 ENOG4105F04 LysR family Transcriptional regulator FOC83_30305 ENOG4105EJC lysr family transcriptional regulator FOC83_30315 ENOG4107RTG Major Facilitator superfamily FOC83_30320 ENOG4108IG5 Transcriptional regulator FOC83_30330 ENOG4108I0C methyltransferase FOC83_30335 ENOG4105ETE Transcriptional regulator (LacI family FOC83_30340 ENOG4108SC4 )-transporter FOC83_30345 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC83_30380 ENOG4105MEW serine threonine protein phosphatase FOC83_30400 ENOG4105CHR reductase FOC83_30410 ENOG4105C26 Dehydrogenase FOC83_30415 ENOG4108R6K riboflavin synthase, subunit alpha FOC83_30425 ENOG4105CSP Major Facilitator Superfamily FOC83_30435 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC83_30445 ENOG4105W1Y Transcriptional regulator FOC83_30470 ENOG4105E0K tonB-dependent siderophore receptor FOC83_30475 ENOG4107R0V Pyruvate dehydrogenase FOC83_30480 ENOG4105CPP Dehydrogenase, E1 component FOC83_30485 ENOG4107QSN dihydrolipoamide acetyltransferase FOC83_30490 ENOG4107QN2 dihydrolipoyl dehydrogenase FOC83_30500 ENOG4105CH7 arginosuccinase FOC83_30505 ENOG4105CUY Mechanosensitive ion channel FOC83_30515 ENOG4108YZA Nitrogen regulatory protein pii FOC83_30520 ENOG4105D7Q type ii secretion system FOC83_30525 ENOG4105GVR general secretion pathway protein D FOC83_30530 ENOG4107QHF type ii secretion system protein e FOC83_30560 ENOG4108RTD type II secretion system protein K FOC83_30565 ENOG4108WWZ General secretion pathway protein J FOC83_30570 ENOG4105X5Z General secretion pathway protein I FOC83_30575 ENOG41069X0 general secretion pathway protein h FOC83_30580 ENOG4108VAU general secretion pathway protein G FOC83_30600 ENOG4105HSS phospholipase C FOC83_30605 ENOG4105DUM transcriptional regulator, lysR family FOC83_30610 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC83_30615 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC83_30620 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC83_30625 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC83_30630 ENOG4108JQ6 ABC transporter FOC83_30635 ENOG4108VWS Yaeq family FOC83_30650 ENOG4105C57 major facilitator superfamily FOC83_30655 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) FOC83_30660 ENOG4105FE9 pseudouridine synthase FOC83_30670 ENOG4105C1P efflux transporter, rnd family, mfp subunit FOC83_30675 ENOG4105BZS acriflavin resistance protein FOC83_30680 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC83_30700 ENOG4105DGW oligopeptidase A FOC83_30705 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FOC83_30710 ENOG4108ZXC Two component transcriptional regulator, luxr family FOC83_30715 ENOG4105BZU Histidine kinase FOC83_30720 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FOC83_30725 ENOG4107QSN dihydrolipoamide acetyltransferase FOC83_30730 ENOG4107QN2 dihydrolipoyl dehydrogenase FOC83_30740 ENOG4105CBN LysR family transcriptional regulator FOC83_30760 ENOG4106R49 Methyltransferase FOC83_30765 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC83_30770 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) FOC83_30775 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region FOC83_30780 ENOG4107RD7 Flagellar Motor Protein, MotA FOC83_30785 ENOG4105ER2 Ompa motb domain protein FOC83_30790 ENOG4108VYJ response regulator receiver protein FOC83_30795 ENOG4105CBS Chea signal transduction histidine kinase FOC83_30800 ENOG4108V3W Chemotaxis protein, CheW FOC83_30805 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_30810 ENOG4105BZU Histidine kinase FOC83_30815 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FOC83_30820 ENOG4108VYJ response regulator receiver protein FOC83_30825 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) FOC83_30830 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_30835 ENOG4105D00 flagellar biosynthetic protein flhB FOC83_30840 ENOG4105D7B Flagellar biosynthesis protein flha FOC83_30845 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC83_30855 ENOG4105M9M anti-sigma28 factor FlgM FOC83_30865 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC83_30870 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC83_30875 ENOG4105W00 Flagellar hook capping protein FOC83_30880 ENOG4105BZE flagellar hook protein, FlgE FOC83_30885 ENOG4108KPB Flagellar basal-body rod protein FlgF FOC83_30890 ENOG4105CGA flagellar basal-body rod protein FlgG FOC83_30905 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FOC83_30910 ENOG4105E1Q flagellar hook-associated protein FOC83_30915 ENOG4105DTJ flagellar hook-associated protein FOC83_30920 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_30925 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_30935 ENOG4105C8Q Methyl-accepting chemotaxis FOC83_30940 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FOC83_30945 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FOC83_30950 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC83_30955 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC83_30960 ENOG4105K0P flagellar biosynthesis protein FOC83_30965 ENOG4105DD5 Flagellar motor switch protein FOC83_30970 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC83_30975 ENOG4107ZI8 flagellar basal body-associated protein flil FOC83_30990 ENOG4108JIR Flagellum-specific ATP synthase FOC83_31000 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC83_31005 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FOC83_31010 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FOC83_31020 ENOG4105D00 flagellar biosynthetic protein flhB FOC83_31035 ENOG4105MQ3 flagellar protein FliS FOC83_31040 ENOG4105DTS flagellar hook-associated FOC83_31045 ENOG41063QE flagellar protein FlaG FOC83_31050 ENOG4106P37 HTH-type transcriptional regulator YjhI FOC83_31060 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC83_31075 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC83_31090 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FOC83_31095 ENOG4108VKG metal-dependent hydrolase FOC83_31100 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FOC83_31110 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FOC83_31115 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC83_31120 ENOG4105CE9 30S ribosomal protein S2 FOC83_31125 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FOC83_31130 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC83_31135 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FOC83_31140 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC83_31145 ENOG4105KNE Phosphatidate cytidylyltransferase FOC83_31150 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC83_31155 ENOG4105DZP Membrane-associated zinc metalloprotease FOC83_31160 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FOC83_31165 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FOC83_31170 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FOC83_31175 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FOC83_31190 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOC83_31210 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC83_31215 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC83_31220 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC83_31240 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FOC83_31245 ENOG4108Z1B Cyclase dehydrase FOC83_31260 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC83_31265 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC83_31280 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FOC83_31285 ENOG4105HHA aminodeoxychorismate lyase FOC83_31290 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FOC83_31295 ENOG4105C6E dna polymerase iii FOC83_31300 ENOG4105F8V Hydrolase, tatD family FOC83_31315 ENOG4106TNF Periplasmic binding protein FOC83_31320 ENOG4105E5Q amino acid AbC transporter FOC83_31325 ENOG4105CDA abc transporter atp-binding protein FOC83_31330 ENOG41088SP formiminoglutamate hydrolase FOC83_31340 ENOG4105D82 Glutamate dehydrogenase FOC83_31350 ENOG4105DF9 Lipoate-protein, ligase FOC83_31365 ENOG4105CYM Glutathione S-transferase FOC83_31375 ENOG4108YXU transcriptional regulator AsnC family FOC83_31380 ENOG4108V06 Glutathione peroxidase FOC83_31385 ENOG4105F27 Major Facilitator FOC83_31390 ENOG4105WAP TPR repeat-containing protein FOC83_31400 ENOG4107S2N Type III effector Hrp-dependent FOC83_31405 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FOC83_31415 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FOC83_31420 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC83_31430 ENOG410846T CoA-transferase family III FOC83_31455 ENOG4108YZN class I peptide chain release factor FOC83_31465 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase