locus-tag	class	description
HPS43_00035	COG1396	sequence-specific DNA binding
HPS43_00040	COG0235	Class ii aldolase
HPS43_00050	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_00070	COG3436	PFAM IS66 Orf2 family protein
HPS43_00135	COG3468	outer membrane autotransporter barrel domain protein
HPS43_00200	COG1024	Enoyl-CoA hydratase
HPS43_00215	COG0583	DNA-binding transcription factor activity
HPS43_00270	COG3384	dioxygenase
HPS43_00315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS43_00320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPS43_00325	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPS43_00340	COG1609	Transcriptional regulator
HPS43_00345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_00350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS43_00360	COG1850	ribulose-bisphosphate carboxylase activity
HPS43_00375	COG0505	Belongs to the CarA family
HPS43_00395	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HPS43_00395	COG3608	succinylglutamate desuccinylase aspartoacylase
HPS43_00400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPS43_00415	COG2207	Transcriptional regulator
HPS43_00420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_00490	COG0668	transmembrane transport
HPS43_00500	COG0166	Belongs to the GPI family
HPS43_00530	COG0387	Pfam Sodium calcium exchanger
HPS43_00535	COG3568	Endonuclease Exonuclease Phosphatase
HPS43_00540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS43_00545	COG0392	lysyltransferase activity
HPS43_00550	COG0297	glycogen (starch) synthase activity
HPS43_00555	COG0366	Alpha amylase catalytic
HPS43_00560	COG0366	Alpha amylase catalytic
HPS43_00575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPS43_00580	COG1640	4-alpha-glucanotransferase
HPS43_00590	COG1113	amino acid transport
HPS43_00615	COG1058	Belongs to the CinA family
HPS43_00615	COG1546	Belongs to the CinA family
HPS43_00625	COG3852	Histidine kinase
HPS43_00645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS43_00655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPS43_00665	COG0477	Major facilitator Superfamily
HPS43_00680	COG4771	TonB-dependent receptor
HPS43_00745	COG2188	Transcriptional regulator
HPS43_00765	COG1414	Transcriptional regulator
HPS43_00770	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS43_00775	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_00785	COG2721	sulfolactate sulfo-lyase activity
HPS43_00795	COG0765	amino acid transport
HPS43_00810	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_00820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPS43_00825	COG3958	Transketolase
HPS43_00830	COG3959	Transketolase, thiamine diphosphate binding domain
HPS43_00835	COG1802	Transcriptional regulator
HPS43_00840	COG0371	Dehydrogenase
HPS43_00845	COG3246	L-lysine catabolic process to acetate
HPS43_00855	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_00865	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_00880	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_00880	COG0604	alcohol dehydrogenase
HPS43_00880	COG3321	synthase
HPS43_00885	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_00915	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_00920	COG0583	DNA-binding transcription factor activity
HPS43_00925	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPS43_00950	COG2814	Major facilitator Superfamily
HPS43_00965	COG3384	dioxygenase
HPS43_00980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPS43_01035	COG4964	Belongs to the GSP D family
HPS43_01080	COG1846	Transcriptional regulator
HPS43_01085	COG4172	Belongs to the ABC transporter superfamily
HPS43_01090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_01095	COG0601	transmembrane transport
HPS43_01110	COG0598	Magnesium transport protein CorA
HPS43_01130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPS43_01145	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPS43_01150	COG1045	serine acetyltransferase
HPS43_01155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPS43_01160	COG0166	Belongs to the GPI family
HPS43_01165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPS43_01170	COG0489	protein tyrosine kinase activity
HPS43_01170	COG3206	protein involved in exopolysaccharide biosynthesis
HPS43_01175	COG1596	polysaccharide export
HPS43_01185	COG1051	belongs to the nudix hydrolase family
HPS43_01205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_01230	COG0463	Glycosyl transferase, family 2
HPS43_01235	COG0110	maltose O-acetyltransferase activity
HPS43_01240	COG0297	glycogen (starch) synthase activity
HPS43_01245	COG2197	response regulator
HPS43_01250	COG2197	response regulator
HPS43_01260	COG1309	transcriptional regulator
HPS43_01265	COG1960	acyl-CoA dehydrogenase activity
HPS43_01275	COG1024	Enoyl-CoA hydratase
HPS43_01275	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_01285	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_01285	COG1024	Enoyl-CoA hydratase
HPS43_01290	COG0183	Belongs to the thiolase family
HPS43_01305	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_01315	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_01325	COG1132	(ABC) transporter
HPS43_01335	COG3395	kinase activity
HPS43_01340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPS43_01350	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS43_01355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPS43_01360	COG1024	Enoyl-CoA hydratase
HPS43_01370	COG1414	Transcriptional regulator
HPS43_01380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPS43_01400	COG0583	DNA-binding transcription factor activity
HPS43_01430	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPS43_01435	COG1309	transcriptional regulator
HPS43_01445	COG1051	belongs to the nudix hydrolase family
HPS43_01450	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HPS43_01460	COG0784	Response regulator, receiver
HPS43_01460	COG2205	protein histidine kinase activity
HPS43_01470	COG2205	protein histidine kinase activity
HPS43_01470	COG0784	Response regulator, receiver
HPS43_01490	COG3258	Cytochrome c
HPS43_01505	COG3278	Belongs to the heme-copper respiratory oxidase family
HPS43_01525	COG0348	domain, Protein
HPS43_01540	COG0527	aspartate kinase activity
HPS43_01545	COG0037	tRNA processing
HPS43_01550	COG0825	malonyl-CoA metabolic process
HPS43_01560	COG0215	cysteine-tRNA ligase activity
HPS43_01575	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPS43_01580	COG1968	undecaprenyl-diphosphatase activity
HPS43_01585	COG1253	flavin adenine dinucleotide binding
HPS43_01600	COG4263	nitrous-oxide reductase activity
HPS43_01615	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPS43_01625	COG1477	protein flavinylation
HPS43_01630	COG4804	nuclease activity
HPS43_01655	COG0668	transmembrane transport
HPS43_01695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS43_01700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_01705	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HPS43_01740	COG0300	oxidoreductase activity
HPS43_01750	COG3360	Dodecin
HPS43_01760	COG0583	DNA-binding transcription factor activity
HPS43_01765	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_01825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPS43_01830	COG2850	peptidyl-arginine hydroxylation
HPS43_01840	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPS43_01845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_01850	COG1994	Peptidase M50
HPS43_01855	COG0009	L-threonylcarbamoyladenylate synthase
HPS43_01860	COG2321	neutral zinc metallopeptidase
HPS43_01920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS43_01925	COG3969	phosphoadenosine phosphosulfate
HPS43_01935	COG1475	DNA binding
HPS43_01940	COG0642	Histidine kinase
HPS43_01965	COG3188	usher protein
HPS43_01970	COG3121	Chaperone
HPS43_01975	COG0840	transmembrane signaling receptor activity
HPS43_02010	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_02015	COG3387	PFAM Glycoside hydrolase 15-related
HPS43_02030	COG0840	transmembrane signaling receptor activity
HPS43_02035	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_02040	COG1280	lysine exporter protein (LysE YggA)
HPS43_02055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS43_02065	COG1917	Cupin 2, conserved barrel domain protein
HPS43_02065	COG2207	Transcriptional regulator
HPS43_02075	COG2084	Dehydrogenase
HPS43_02090	COG1802	Transcriptional regulator
HPS43_02105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS43_02130	COG0745	RESPONSE REGULATOR receiver
HPS43_02135	COG2205	protein histidine kinase activity
HPS43_02140	COG1764	response to oxidative stress
HPS43_02155	COG0586	Pfam SNARE associated Golgi protein
HPS43_02160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_02165	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPS43_02225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_02230	COG0765	amino acid transport
HPS43_02240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_02250	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_02275	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_02300	COG0348	domain, Protein
HPS43_02320	COG3278	Belongs to the heme-copper respiratory oxidase family
HPS43_02335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPS43_02340	COG0156	8-amino-7-oxononanoate synthase activity
HPS43_02350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPS43_02350	COG4106	trans-aconitate 2-methyltransferase activity
HPS43_02355	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPS43_02355	COG4106	trans-aconitate 2-methyltransferase activity
HPS43_02370	COG2224	Isocitrate lyase
HPS43_02375	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPS43_02375	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPS43_02380	COG1858	cytochrome C peroxidase
HPS43_02385	COG0583	DNA-binding transcription factor activity
HPS43_02390	COG0473	3-isopropylmalate dehydrogenase activity
HPS43_02400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPS43_02415	COG0736	holo-[acyl-carrier-protein] synthase activity
HPS43_02420	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPS43_02430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_02435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_02460	COG3842	ATPase activity
HPS43_02465	COG4149	molybdate abc transporter
HPS43_02470	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPS43_02475	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HPS43_02500	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPS43_02510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_02520	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPS43_02530	COG0667	Aldo Keto reductase
HPS43_02540	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_02545	COG1024	Enoyl-CoA hydratase
HPS43_02555	COG1802	Transcriptional regulator
HPS43_02565	COG0183	Belongs to the thiolase family
HPS43_02570	COG1960	acyl-CoA dehydrogenase activity
HPS43_02575	COG1960	acyl-CoA dehydrogenase activity
HPS43_02580	COG0583	DNA-binding transcription factor activity
HPS43_02605	COG4213	ABC transporter substrate-binding protein
HPS43_02610	COG1129	ABC transporter
HPS43_02615	COG4214	carbohydrate transport
HPS43_02620	COG2706	6-phosphogluconolactonase activity
HPS43_02625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_02640	COG4175	Glycine betaine
HPS43_02640	COG3448	diguanylate cyclase activity
HPS43_02645	COG4176	ABC-type proline glycine betaine transport system permease component
HPS43_02655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS43_02660	COG2814	Major facilitator Superfamily
HPS43_02665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPS43_02670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPS43_02705	COG1686	Belongs to the peptidase S11 family
HPS43_02715	COG1846	Transcriptional regulator
HPS43_02720	COG2814	Major facilitator Superfamily
HPS43_02725	COG0495	leucyl-tRNA aminoacylation
HPS43_02740	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPS43_02770	COG0477	Major facilitator Superfamily
HPS43_02780	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_02795	COG0583	DNA-binding transcription factor activity
HPS43_02845	COG0583	DNA-binding transcription factor activity
HPS43_02850	COG0427	acetyl-CoA hydrolase
HPS43_02855	COG0583	DNA-binding transcription factor activity
HPS43_02860	COG3264	Mechanosensitive ion channel
HPS43_02860	COG1511	domain protein
HPS43_02910	COG3842	ATPase activity
HPS43_02915	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS43_02920	COG1177	transmembrane transport
HPS43_02925	COG3938	Belongs to the proline racemase family
HPS43_02940	COG0517	IMP dehydrogenase activity
HPS43_02970	COG0500	methyltransferase
HPS43_02985	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HPS43_03000	COG0667	Aldo Keto reductase
HPS43_03005	COG2207	Transcriptional regulator
HPS43_03010	COG0583	DNA-binding transcription factor activity
HPS43_03015	COG1335	isochorismatase
HPS43_03025	COG2841	Protein conserved in bacteria
HPS43_03040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS43_03045	COG0438	transferase activity, transferring glycosyl groups
HPS43_03115	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPS43_03140	COG2814	Major facilitator Superfamily
HPS43_03145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPS43_03170	COG0248	Ppx GppA phosphatase
HPS43_03180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPS43_03190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPS43_03195	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPS43_03200	COG1534	Rna-binding protein
HPS43_03205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPS43_03210	COG0840	transmembrane signaling receptor activity
HPS43_03215	COG2233	PERMEase
HPS43_03235	COG3842	ATPase activity
HPS43_03250	COG4221	oxidoreductase activity
HPS43_03260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPS43_03265	COG0505	Belongs to the CarA family
HPS43_03285	COG0745	RESPONSE REGULATOR receiver
HPS43_03300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_03310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS43_03315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_03330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPS43_03340	COG1074	ATP-dependent DNA helicase activity
HPS43_03360	COG2070	2-Nitropropane dioxygenase
HPS43_03380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_03395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS43_03400	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_03415	COG1686	Belongs to the peptidase S11 family
HPS43_03430	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HPS43_03435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPS43_03440	COG4974	Belongs to the 'phage' integrase family
HPS43_03445	COG0583	DNA-binding transcription factor activity
HPS43_03450	COG0028	Belongs to the TPP enzyme family
HPS43_03495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPS43_03540	COG0028	Belongs to the TPP enzyme family
HPS43_03545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_03560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS43_03565	COG1414	Transcriptional regulator
HPS43_03570	COG0009	L-threonylcarbamoyladenylate synthase
HPS43_03575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPS43_03580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPS43_03585	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPS43_03595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPS43_03615	COG1301	dicarboxylic acid transport
HPS43_03625	COG3454	Phosphonate metabolism
HPS43_03630	COG4778	phosphonate C-P lyase system protein PhnL
HPS43_03635	COG4107	phosphonate C-P lyase system protein PhnK
HPS43_03640	COG3627	carbon phosphorus lyase activity
HPS43_03645	COG3626	phosphonate metabolism
HPS43_03650	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HPS43_03655	COG3624	Phosphonate C-P lyase system protein PhnG
HPS43_03660	COG2188	Transcriptional regulator
HPS43_03665	COG3454	Phosphonate metabolism
HPS43_03670	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HPS43_03675	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HPS43_03680	COG0583	DNA-binding transcription factor activity
HPS43_03685	COG0405	Gamma-glutamyltransferase
HPS43_03700	COG3639	organic phosphonate transmembrane transporter activity
HPS43_03705	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HPS43_03710	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HPS43_03720	COG0640	Transcriptional regulator
HPS43_03730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPS43_03740	COG0739	heme binding
HPS43_03750	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPS43_03760	COG0306	phosphate transporter
HPS43_03795	COG0625	glutathione transferase activity
HPS43_03815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPS43_03820	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPS43_03835	COG0126	phosphoglycerate kinase activity
HPS43_03840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPS43_03845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPS43_03855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPS43_03860	COG2732	(Barnase) inhibitor
HPS43_03870	COG0280	phosphate acetyltransferase
HPS43_03870	COG0281	malic enzyme
HPS43_03905	COG0753	catalase activity
HPS43_03915	COG0741	lytic transglycosylase activity
HPS43_03920	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPS43_03935	COG4575	ribosome binding
HPS43_03945	COG1116	anion transmembrane transporter activity
HPS43_03950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_03955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS43_03960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPS43_03960	COG1648	precorrin-2 dehydrogenase activity
HPS43_03965	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPS43_03970	COG2027	D-alanyl-D-alanine carboxypeptidase
HPS43_03985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS43_03995	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPS43_04000	COG0343	queuine tRNA-ribosyltransferase activity
HPS43_04010	COG3077	Addiction module antitoxin, RelB DinJ family
HPS43_04015	COG1862	Preprotein translocase
HPS43_04020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPS43_04025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPS43_04045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPS43_04055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPS43_04060	COG1702	phosphate starvation-inducible protein PhoH
HPS43_04065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPS43_04070	COG4535	Mg2 and Co2 transporter CorC
HPS43_04075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPS43_04080	COG0667	Aldo Keto reductase
HPS43_04125	COG0697	spore germination
HPS43_04135	COG0678	peroxiredoxin activity
HPS43_04145	COG0412	Dienelactone hydrolase
HPS43_04155	COG0315	cyclic pyranopterin monophosphate synthase activity
HPS43_04165	COG0314	molybdopterin synthase activity
HPS43_04170	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPS43_04175	COG0303	'Molybdopterin
HPS43_04185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPS43_04205	COG3383	formate dehydrogenase (NAD+) activity
HPS43_04210	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPS43_04220	COG2223	nitrite transmembrane transporter activity
HPS43_04245	COG0583	DNA-binding transcription factor activity
HPS43_04250	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPS43_04265	COG2205	protein histidine kinase activity
HPS43_04270	COG0745	RESPONSE REGULATOR receiver
HPS43_04285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPS43_04300	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_04320	COG2828	Protein conserved in bacteria
HPS43_04325	COG0583	DNA-binding transcription factor activity
HPS43_04330	COG0456	acetyltransferase
HPS43_04370	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_04395	COG4774	siderophore transport
HPS43_04415	COG4585	Histidine kinase
HPS43_04420	COG0671	phosphoesterase, PA-phosphatase related
HPS43_04435	COG1666	GTP binding
HPS43_04440	COG1120	ATPase activity
HPS43_04445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_04450	COG4558	Periplasmic binding protein
HPS43_04455	COG3720	iron ion transport
HPS43_04465	COG3712	iron ion homeostasis
HPS43_04470	COG1595	DNA-templated transcription, initiation
HPS43_04485	COG2378	regulation of single-species biofilm formation
HPS43_04510	COG0583	DNA-binding transcription factor activity
HPS43_04515	COG1113	amino acid transport
HPS43_04525	COG1522	sequence-specific DNA binding
HPS43_04530	COG1272	protein, Hemolysin III
HPS43_04535	COG3191	aminopeptidase activity
HPS43_04540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_04545	COG0765	amino acid transport
HPS43_04555	COG4942	peptidase
HPS43_04575	COG1999	signal sequence binding
HPS43_04595	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HPS43_04605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS43_04610	COG1845	cytochrome c oxidase, subunit III
HPS43_04615	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPS43_04625	COG4772	TonB-dependent receptor
HPS43_04645	COG0280	phosphate acetyltransferase
HPS43_04645	COG0281	malic enzyme
HPS43_04660	COG0697	spore germination
HPS43_04695	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_04705	COG0583	DNA-binding transcription factor activity
HPS43_04725	COG1396	sequence-specific DNA binding
HPS43_04730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS43_04755	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPS43_04770	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPS43_04775	COG1285	pathogenesis
HPS43_04780	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_04785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPS43_04800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPS43_04815	COG3712	iron ion homeostasis
HPS43_04820	COG1595	DNA-templated transcription, initiation
HPS43_04830	COG4221	oxidoreductase activity
HPS43_04835	COG4773	Receptor
HPS43_04855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPS43_04860	COG0330	HflC and HflK could
HPS43_04885	COG2807	transmembrane transport
HPS43_04890	COG2207	Transcriptional regulator
HPS43_04895	COG4106	trans-aconitate 2-methyltransferase activity
HPS43_04910	COG0583	DNA-binding transcription factor activity
HPS43_04950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPS43_04955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_04960	COG0477	Major facilitator Superfamily
HPS43_04965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPS43_04970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS43_04975	COG1845	cytochrome c oxidase, subunit III
HPS43_04980	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPS43_04990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_04995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_05000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_05010	COG2814	Major facilitator Superfamily
HPS43_05025	COG0625	glutathione transferase activity
HPS43_05085	COG3707	response regulator
HPS43_05090	COG2146	nitrite reductase [NAD(P)H] activity
HPS43_05090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPS43_05095	COG2146	nitrite reductase [NAD(P)H] activity
HPS43_05095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPS43_05100	COG0243	molybdopterin cofactor binding
HPS43_05110	COG0667	Aldo Keto reductase
HPS43_05130	COG0583	DNA-binding transcription factor activity
HPS43_05135	COG0023	Translation Initiation Factor
HPS43_05145	COG0454	-acetyltransferase
HPS43_05145	COG0456	acetyltransferase
HPS43_05150	COG0583	DNA-binding transcription factor activity
HPS43_05155	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_05170	COG0840	transmembrane signaling receptor activity
HPS43_05175	COG2199	diguanylate cyclase activity
HPS43_05175	COG2203	Gaf domain
HPS43_05180	COG0640	Transcriptional regulator
HPS43_05190	COG0740	serine-type endopeptidase activity
HPS43_05195	COG2814	Major facilitator Superfamily
HPS43_05225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_05235	COG0596	Alpha beta hydrolase
HPS43_05245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPS43_05255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS43_05260	COG0583	DNA-binding transcription factor activity
HPS43_05295	COG0028	Belongs to the TPP enzyme family
HPS43_05315	COG1230	cation diffusion facilitator family transporter
HPS43_05335	COG1132	(ABC) transporter
HPS43_05345	COG1201	RNA secondary structure unwinding
HPS43_05350	COG1793	dna ligase
HPS43_05355	COG1793	dna ligase
HPS43_05355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPS43_05390	COG1960	acyl-CoA dehydrogenase activity
HPS43_05400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_05405	COG0697	spore germination
HPS43_05415	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_05425	COG0436	Aminotransferase
HPS43_05430	COG0583	DNA-binding transcription factor activity
HPS43_05435	COG0583	DNA-binding transcription factor activity
HPS43_05465	COG0583	DNA-binding transcription factor activity
HPS43_05470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_05475	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_05480	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_05495	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_05540	COG1595	DNA-templated transcription, initiation
HPS43_05570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPS43_05575	COG0459	protein refolding
HPS43_05585	COG1846	Transcriptional regulator
HPS43_05605	COG1917	Cupin 2, conserved barrel domain protein
HPS43_05630	COG1137	ATPase activity
HPS43_05640	COG0246	Mannitol dehydrogenase
HPS43_05645	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPS43_05650	COG1252	NADH dehydrogenase
HPS43_05655	COG0284	orotidine-5'-phosphate decarboxylase activity
HPS43_05660	COG1546	Belongs to the CinA family
HPS43_05675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPS43_05680	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPS43_05705	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HPS43_05710	COG3639	organic phosphonate transmembrane transporter activity
HPS43_05715	COG3639	organic phosphonate transmembrane transporter activity
HPS43_05735	COG0742	ribosomal rna small subunit methyltransferase
HPS43_05740	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPS43_05745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPS43_05750	COG3135	benzoate transporter
HPS43_05765	COG2814	Major facilitator Superfamily
HPS43_05785	COG4773	Receptor
HPS43_05820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPS43_05840	COG0582	viral genome integration into host DNA
HPS43_05845	COG0012	GTP binding
HPS43_05855	COG0193	aminoacyl-tRNA hydrolase activity
HPS43_05875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPS43_05880	COG0840	transmembrane signaling receptor activity
HPS43_05895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPS43_05920	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPS43_05930	COG0204	Acyl-transferase
HPS43_05935	COG1368	sulfuric ester hydrolase activity
HPS43_05940	COG2186	Transcriptional regulator
HPS43_05945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_05955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_05965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS43_05975	COG2205	protein histidine kinase activity
HPS43_05980	COG0745	RESPONSE REGULATOR receiver
HPS43_05985	COG0277	FAD linked oxidase domain protein
HPS43_06000	COG0166	Belongs to the GPI family
HPS43_06005	COG0405	Gamma-glutamyltransferase
HPS43_06010	COG0438	transferase activity, transferring glycosyl groups
HPS43_06015	COG0438	transferase activity, transferring glycosyl groups
HPS43_06020	COG0438	transferase activity, transferring glycosyl groups
HPS43_06045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPS43_06050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPS43_06080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_06100	COG0747	negative chemotaxis
HPS43_06105	COG0601	transmembrane transport
HPS43_06110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_06115	COG4172	Belongs to the ABC transporter superfamily
HPS43_06120	COG0154	amidase activity
HPS43_06135	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPS43_06135	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPS43_06140	COG0509	glycine decarboxylation via glycine cleavage system
HPS43_06145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPS43_06160	COG2081	HI0933 family
HPS43_06165	COG1982	Orn Lys Arg decarboxylase major
HPS43_06180	COG3706	GGDEF domain
HPS43_06190	COG0717	Belongs to the dCTP deaminase family
HPS43_06205	COG0489	protein tyrosine kinase activity
HPS43_06215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS43_06215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS43_06235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPS43_06235	COG2755	lipolytic protein G-D-S-L family
HPS43_06250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPS43_06275	COG2200	EAL domain
HPS43_06295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_06300	COG1129	ABC transporter
HPS43_06300	COG0842	Transport permease protein
HPS43_06305	COG0842	Transport permease protein
HPS43_06315	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_06320	COG0583	DNA-binding transcription factor activity
HPS43_06325	COG0697	spore germination
HPS43_06335	COG1271	oxidase subunit
HPS43_06340	COG1294	oxidase, subunit
HPS43_06350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_06385	COG3258	Cytochrome c
HPS43_06395	COG0625	glutathione transferase activity
HPS43_06400	COG2986	histidine ammonia-lyase
HPS43_06405	COG1234	tRNA 3'-trailer cleavage
HPS43_06415	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPS43_06430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPS43_06455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPS43_06470	COG2828	Protein conserved in bacteria
HPS43_06475	COG1595	DNA-templated transcription, initiation
HPS43_06480	COG3712	iron ion homeostasis
HPS43_06490	COG0165	Argininosuccinate lyase
HPS43_06495	COG2205	protein histidine kinase activity
HPS43_06505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS43_06535	COG0477	Major facilitator Superfamily
HPS43_06545	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_06550	COG3246	L-lysine catabolic process to acetate
HPS43_06565	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPS43_06570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS43_06575	COG0154	amidase activity
HPS43_06580	COG0372	Belongs to the citrate synthase family
HPS43_06585	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_06620	COG0583	DNA-binding transcription factor activity
HPS43_06625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS43_06630	COG0501	Belongs to the peptidase M48B family
HPS43_06675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPS43_06685	COG0542	response to heat
HPS43_06690	COG0071	Belongs to the small heat shock protein (HSP20) family
HPS43_06710	COG0583	DNA-binding transcription factor activity
HPS43_06725	COG1192	Involved in chromosome partitioning
HPS43_06895	COG3621	Patatin-like phospholipase
HPS43_06965	COG2003	Belongs to the UPF0758 family
HPS43_07025	COG0582	viral genome integration into host DNA
HPS43_07040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS43_07045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_07050	COG0583	DNA-binding transcription factor activity
HPS43_07055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPS43_07075	COG1652	LysM domain
HPS43_07080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPS43_07085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPS43_07100	COG0625	glutathione transferase activity
HPS43_07135	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_07170	COG3550	peptidyl-serine autophosphorylation
HPS43_07190	COG1414	Transcriptional regulator
HPS43_07200	COG0800	Aldolase
HPS43_07205	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_07210	COG2271	Major facilitator Superfamily
HPS43_07215	COG1131	(ABC) transporter
HPS43_07230	COG4774	siderophore transport
HPS43_07235	COG2814	Major facilitator Superfamily
HPS43_07240	COG0326	Molecular chaperone. Has ATPase activity
HPS43_07250	COG2233	PERMEase
HPS43_07335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_07340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS43_07345	COG3246	L-lysine catabolic process to acetate
HPS43_07355	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_07495	COG0583	DNA-binding transcription factor activity
HPS43_07505	COG1695	Transcriptional regulator
HPS43_07520	COG0477	Major facilitator Superfamily
HPS43_07535	COG0277	FAD linked oxidase domain protein
HPS43_07545	COG3842	ATPase activity
HPS43_07550	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS43_07570	COG0628	permease
HPS43_07575	COG0583	DNA-binding transcription factor activity
HPS43_07580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_07600	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HPS43_07610	COG2186	Transcriptional regulator
HPS43_07620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPS43_07645	COG0410	ABC transporter
HPS43_07650	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_07655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPS43_07665	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPS43_07670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPS43_07675	COG0583	DNA-binding transcription factor activity
HPS43_07680	COG0129	dihydroxy-acid dehydratase activity
HPS43_07690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS43_07695	COG0583	DNA-binding transcription factor activity
HPS43_07710	COG2200	EAL domain
HPS43_07715	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPS43_07720	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPS43_07725	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_07730	COG2031	fatty acid transporter
HPS43_07740	COG1414	Transcriptional regulator
HPS43_07750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS43_07755	COG4829	muconolactone delta-isomerase
HPS43_07765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS43_07785	COG0288	reversible hydration of carbon dioxide
HPS43_07790	COG1802	Transcriptional regulator
HPS43_07795	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_07805	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_07825	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_07840	COG0625	glutathione transferase activity
HPS43_07855	COG0583	DNA-binding transcription factor activity
HPS43_07865	COG0583	DNA-binding transcription factor activity
HPS43_07870	COG0477	Major facilitator Superfamily
HPS43_07895	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_07915	COG1464	Belongs to the NlpA lipoprotein family
HPS43_07930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPS43_07935	COG2890	protein-(glutamine-N5) methyltransferase activity
HPS43_07940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPS43_07955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPS43_07960	COG1280	lysine exporter protein (LysE YggA)
HPS43_07965	COG1522	sequence-specific DNA binding
HPS43_07985	COG3622	Belongs to the hyi family
HPS43_08005	COG0583	DNA-binding transcription factor activity
HPS43_08010	COG2186	Transcriptional regulator
HPS43_08015	COG3395	kinase activity
HPS43_08020	COG2084	Dehydrogenase
HPS43_08025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_08030	COG3622	Belongs to the hyi family
HPS43_08035	COG0235	Class ii aldolase
HPS43_08105	COG0142	geranyltranstransferase activity
HPS43_08110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPS43_08115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPS43_08120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPS43_08125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPS43_08140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPS43_08145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPS43_08155	COG2186	Transcriptional regulator
HPS43_08160	COG5002	protein histidine kinase activity
HPS43_08160	COG5001	Diguanylate cyclase
HPS43_08160	COG3447	MASE1 domain protein
HPS43_08165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPS43_08170	COG0793	Belongs to the peptidase S41A family
HPS43_08175	COG4942	peptidase
HPS43_08180	COG0588	phosphoglycerate mutase activity
HPS43_08190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPS43_08195	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPS43_08200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPS43_08205	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_08215	COG1040	competence protein
HPS43_08220	COG2226	methyltransferase
HPS43_08225	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HPS43_08230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPS43_08235	COG0569	domain protein
HPS43_08240	COG2204	response regulator
HPS43_08245	COG5000	phosphorelay sensor kinase activity
HPS43_08255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPS43_08255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPS43_08260	COG1280	lysine exporter protein (LysE YggA)
HPS43_08265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPS43_08275	COG1733	regulation of RNA biosynthetic process
HPS43_08295	COG0546	phosphoglycolate phosphatase activity
HPS43_08305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPS43_08310	COG0242	peptide deformylase activity
HPS43_08315	COG0758	DNA mediated transformation
HPS43_08330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_08335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_08340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPS43_08345	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_08360	COG1238	metal cluster binding
HPS43_08365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPS43_08370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_08390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPS43_08395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPS43_08400	COG4988	ABC transporter
HPS43_08410	COG1294	oxidase, subunit
HPS43_08425	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HPS43_08435	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPS43_08450	COG1137	ATPase activity
HPS43_08455	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPS43_08465	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HPS43_08470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_08485	COG1660	Displays ATPase and GTPase activities
HPS43_08495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPS43_08500	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPS43_08505	COG0792	nuclease activity
HPS43_08510	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPS43_08520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_08525	COG1464	Belongs to the NlpA lipoprotein family
HPS43_08530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPS43_08540	COG1309	transcriptional regulator
HPS43_08545	COG0471	metal ion transport
HPS43_08550	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPS43_08555	COG0772	Belongs to the SEDS family
HPS43_08560	COG0768	penicillin binding
HPS43_08570	COG1792	Involved in formation and maintenance of cell shape
HPS43_08575	COG1077	Cell shape determining protein MreB Mrl
HPS43_08580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPS43_08585	COG0154	amidase activity
HPS43_08590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPS43_08605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPS43_08610	COG0708	Exodeoxyribonuclease III
HPS43_08615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPS43_08625	COG0583	DNA-binding transcription factor activity
HPS43_08635	COG0583	DNA-binding transcription factor activity
HPS43_08660	COG1764	response to oxidative stress
HPS43_08665	COG1846	Transcriptional regulator
HPS43_08725	COG0640	Transcriptional regulator
HPS43_08755	COG3189	MarR family transcriptional regulator
HPS43_08775	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_08780	COG0352	thiamine-phosphate diphosphorylase activity
HPS43_08780	COG0351	phosphomethylpyrimidine kinase
HPS43_08780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPS43_08840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPS43_08845	COG0513	Belongs to the DEAD box helicase family
HPS43_08855	COG0617	tRNA 3'-terminal CCA addition
HPS43_08865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPS43_08870	COG2308	Evidence 4 Homologs of previously reported genes of
HPS43_08880	COG1305	Transglutaminase-like
HPS43_08900	COG1950	PFAM Membrane protein of
HPS43_08905	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HPS43_08910	COG0438	transferase activity, transferring glycosyl groups
HPS43_08925	COG0066	3-isopropylmalate dehydratase activity
HPS43_08940	COG0583	DNA-binding transcription factor activity
HPS43_08950	COG0477	Major facilitator Superfamily
HPS43_08955	COG0154	amidase activity
HPS43_08960	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPS43_08975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPS43_08985	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPS43_08990	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HPS43_09000	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPS43_09015	COG0735	belongs to the Fur family
HPS43_09020	COG0523	cobalamin synthesis protein
HPS43_09030	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPS43_09035	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPS43_09045	COG2096	Adenosyltransferase
HPS43_09055	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPS43_09065	COG0463	Glycosyl transferase, family 2
HPS43_09080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS43_09095	COG4106	trans-aconitate 2-methyltransferase activity
HPS43_09100	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HPS43_09115	COG0321	lipoyl(octanoyl) transferase activity
HPS43_09120	COG2921	Belongs to the UPF0250 family
HPS43_09130	COG1686	Belongs to the peptidase S11 family
HPS43_09155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPS43_09165	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HPS43_09185	COG0859	PFAM glycosyl transferase family 9
HPS43_09195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPS43_09215	COG0110	maltose O-acetyltransferase activity
HPS43_09235	COG2089	acid synthase
HPS43_09250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPS43_09275	COG1086	Polysaccharide biosynthesis protein
HPS43_09280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_09295	COG0477	Major facilitator Superfamily
HPS43_09315	COG3568	Endonuclease Exonuclease Phosphatase
HPS43_09320	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPS43_09345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS43_09360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_09365	COG1956	GAF domain-containing protein
HPS43_09370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_09395	COG2186	Transcriptional regulator
HPS43_09430	COG4106	trans-aconitate 2-methyltransferase activity
HPS43_09440	COG2814	Major facilitator Superfamily
HPS43_09450	COG0625	glutathione transferase activity
HPS43_09455	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPS43_09460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPS43_09465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPS43_09475	COG1965	Belongs to the frataxin family
HPS43_09485	COG0019	diaminopimelate decarboxylase activity
HPS43_09490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPS43_09495	COG1333	cytochrome c biogenesis protein
HPS43_09505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HPS43_09520	COG4232	protein-disulfide reductase activity
HPS43_09525	COG1324	tolerance protein
HPS43_09535	COG0203	ribosomal protein L17
HPS43_09540	COG0202	RNA polymerase activity
HPS43_09545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPS43_09550	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPS43_09555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPS43_09560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPS43_09565	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPS43_09570	COG0201	protein transport
HPS43_09575	COG0200	Binds to the 23S rRNA
HPS43_09580	COG1841	ribosomal large subunit assembly
HPS43_09585	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPS43_09590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPS43_09595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPS43_09600	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPS43_09605	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPS43_09610	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPS43_09615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPS43_09620	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPS43_09635	COG2169	Transcriptional regulator
HPS43_09635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPS43_09685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPS43_09690	COG0255	Belongs to the universal ribosomal protein uL29 family
HPS43_09695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPS43_09700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPS43_09705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPS43_09710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPS43_09715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPS43_09720	COG0089	rRNA binding
HPS43_09730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPS43_09735	COG0051	transcription antitermination factor activity, RNA binding
HPS43_09740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPS43_09745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPS43_09750	COG0049	tRNA binding
HPS43_09755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HPS43_09760	COG0745	RESPONSE REGULATOR receiver
HPS43_09775	COG5002	protein histidine kinase activity
HPS43_09790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPS43_09795	COG0085	RNA polymerase activity
HPS43_09800	COG0222	ribosome binding
HPS43_09805	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPS43_09810	COG0081	regulation of translation
HPS43_09815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPS43_09825	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPS43_09835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPS43_09875	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS43_09880	COG3842	ATPase activity
HPS43_09890	COG1349	DNA-binding transcription factor activity
HPS43_09915	COG0583	DNA-binding transcription factor activity
HPS43_09920	COG0252	asparaginase activity
HPS43_09925	COG1475	DNA binding
HPS43_09935	COG1192	Involved in chromosome partitioning
HPS43_09940	COG0357	Ribosomal RNA small subunit methyltransferase G
HPS43_09945	COG0445	tRNA wobble uridine modification
HPS43_09950	COG1278	Cold shock
HPS43_09955	COG3180	Ammonia monooxygenase
HPS43_09960	COG0436	Aminotransferase
HPS43_09990	COG0038	chloride channel
HPS43_10000	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPS43_10010	COG0601	transmembrane transport
HPS43_10015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_10020	COG0444	Belongs to the ABC transporter superfamily
HPS43_10025	COG4608	Belongs to the ABC transporter superfamily
HPS43_10030	COG1473	amidohydrolase
HPS43_10040	COG2175	clavaminate synthase activity
HPS43_10050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPS43_10055	COG0753	catalase activity
HPS43_10065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HPS43_10070	COG0594	ribonuclease P activity
HPS43_10075	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPS43_10080	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPS43_10085	COG0592	DNA-directed DNA polymerase activity
HPS43_10095	COG0583	DNA-binding transcription factor activity
HPS43_10120	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HPS43_10135	COG0583	DNA-binding transcription factor activity
HPS43_10140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_10145	COG0765	amino acid transport
HPS43_10150	COG0765	amino acid transport
HPS43_10155	COG1126	abc transporter atp-binding protein
HPS43_10195	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS43_10200	COG1177	transmembrane transport
HPS43_10255	COG1609	Transcriptional regulator
HPS43_10265	COG3842	ATPase activity
HPS43_10270	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS43_10275	COG1177	transmembrane transport
HPS43_10300	COG0251	oxidation-reduction process
HPS43_10305	COG0402	S-adenosylhomocysteine deaminase activity
HPS43_10325	COG1744	ABC transporter substrate-binding protein PnrA-like
HPS43_10335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPS43_10350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPS43_10365	COG2814	Major facilitator Superfamily
HPS43_10380	COG3781	membrane
HPS43_10385	COG1522	sequence-specific DNA binding
HPS43_10390	COG0028	Belongs to the TPP enzyme family
HPS43_10395	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_10400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_10425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPS43_10430	COG2922	Belongs to the Smg family
HPS43_10440	COG2358	TRAP transporter, solute receptor (TAXI family
HPS43_10460	COG0765	amino acid transport
HPS43_10465	COG0765	amino acid transport
HPS43_10470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_10475	COG3422	double-strand break repair
HPS43_10480	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_10485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPS43_10545	COG4977	sequence-specific DNA binding
HPS43_10550	COG2814	Major facilitator Superfamily
HPS43_10560	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPS43_10570	COG3339	Conserved Protein
HPS43_10600	COG2186	Transcriptional regulator
HPS43_10605	COG2814	Major facilitator Superfamily
HPS43_10615	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HPS43_10660	COG1595	DNA-templated transcription, initiation
HPS43_10665	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_10680	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_10690	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_10725	COG2207	Transcriptional regulator
HPS43_10745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPS43_10750	COG0183	Belongs to the thiolase family
HPS43_10755	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HPS43_10760	COG1960	acyl-CoA dehydrogenase activity
HPS43_10765	COG1473	amidohydrolase
HPS43_10775	COG1742	UPF0060 membrane protein
HPS43_10780	COG0789	Transcriptional regulator
HPS43_10790	COG1280	lysine exporter protein (LysE YggA)
HPS43_10815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPS43_10825	COG0018	arginyl-trna synthetase
HPS43_10840	COG0395	ABC-type sugar transport system, permease component
HPS43_10845	COG1175	transmembrane transport
HPS43_10850	COG1653	transport
HPS43_10855	COG3842	ATPase activity
HPS43_10860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS43_10865	COG1609	Transcriptional regulator
HPS43_10875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS43_10890	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPS43_10900	COG0583	DNA-binding transcription factor activity
HPS43_10920	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HPS43_10925	COG1280	lysine exporter protein (LysE YggA)
HPS43_10930	COG0513	Belongs to the DEAD box helicase family
HPS43_10935	COG5339	Protein conserved in bacteria
HPS43_10940	COG5339	Protein conserved in bacteria
HPS43_10945	COG1228	amidohydrolase
HPS43_10955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_10960	COG0601	transmembrane transport
HPS43_10965	COG0747	negative chemotaxis
HPS43_10970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPS43_10980	COG2207	Transcriptional regulator
HPS43_10980	COG3708	Transcriptional regulator
HPS43_11000	COG0583	DNA-binding transcription factor activity
HPS43_11035	COG2969	positive regulation of protein catabolic process
HPS43_11040	COG0625	glutathione transferase activity
HPS43_11045	COG2857	Cytochrome c1
HPS43_11050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPS43_11055	COG0723	plastoquinol--plastocyanin reductase activity
HPS43_11060	COG1970	mechanosensitive ion channel activity
HPS43_11065	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPS43_11070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS43_11085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPS43_11090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPS43_11095	COG0537	adenosine 5'-monophosphoramidase activity
HPS43_11100	COG0140	phosphoribosyl-ATP diphosphatase activity
HPS43_11110	COG0107	imidazoleglycerol-phosphate synthase activity
HPS43_11115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPS43_11120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPS43_11125	COG0131	Imidazoleglycerol-phosphate dehydratase
HPS43_11130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPS43_11135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPS43_11140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPS43_11145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPS43_11155	COG0842	Transport permease protein
HPS43_11160	COG1131	(ABC) transporter
HPS43_11170	COG2853	Lipoprotein
HPS43_11175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPS43_11180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPS43_11185	COG1127	ABC transporter
HPS43_11190	COG2070	2-Nitropropane dioxygenase
HPS43_11200	COG0477	Major facilitator Superfamily
HPS43_11215	COG0583	DNA-binding transcription factor activity
HPS43_11220	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPS43_11225	COG0511	ligase activity, forming carbon-carbon bonds
HPS43_11240	COG1984	allophanate hydrolase subunit 2
HPS43_11255	COG0070	glutamate synthase
HPS43_11255	COG0069	glutamate synthase activity
HPS43_11255	COG0067	glutamate synthase
HPS43_11280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS43_11300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS43_11330	COG1612	heme a metabolic process
HPS43_11340	COG1999	signal sequence binding
HPS43_11360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPS43_11365	COG2814	Major facilitator Superfamily
HPS43_11375	COG0438	transferase activity, transferring glycosyl groups
HPS43_11420	COG1074	ATP-dependent DNA helicase activity
HPS43_11435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPS43_11455	COG4774	siderophore transport
HPS43_11460	COG4592	Periplasmic binding protein
HPS43_11465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_11470	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_11475	COG1120	ATPase activity
HPS43_11480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS43_11495	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPS43_11520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPS43_11525	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPS43_11530	COG2814	Major facilitator Superfamily
HPS43_11535	COG0583	DNA-binding transcription factor activity
HPS43_11545	COG2423	ornithine cyclodeaminase activity
HPS43_11550	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HPS43_11555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPS43_11565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPS43_11575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPS43_11580	COG0463	Glycosyl transferase, family 2
HPS43_11630	COG0737	Belongs to the 5'-nucleotidase family
HPS43_11645	COG2188	Transcriptional regulator
HPS43_11655	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPS43_11660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPS43_11675	COG0840	transmembrane signaling receptor activity
HPS43_11680	COG2814	Major facilitator Superfamily
HPS43_11695	COG3188	usher protein
HPS43_11755	COG1802	Transcriptional regulator
HPS43_11765	COG3069	C4-dicarboxylate transmembrane transporter activity
HPS43_11770	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_11795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_11805	COG0747	negative chemotaxis
HPS43_11830	COG1464	Belongs to the NlpA lipoprotein family
HPS43_11835	COG0431	NADPH-dependent FMN reductase
HPS43_11840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS43_11845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS43_11850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_11865	COG2011	ABC-type metal ion transport system permease component
HPS43_11870	COG1464	Belongs to the NlpA lipoprotein family
HPS43_11875	COG1116	anion transmembrane transporter activity
HPS43_11880	COG3585	molybdate ion transport
HPS43_11885	COG3064	Membrane
HPS43_11910	COG1607	acyl-coa hydrolase
HPS43_11925	COG0437	4 iron, 4 sulfur cluster binding
HPS43_11930	COG2864	formate dehydrogenase
HPS43_11945	COG3276	selenocysteine insertion sequence binding
HPS43_11955	COG1215	transferase activity, transferring glycosyl groups
HPS43_11960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_11965	COG1305	Transglutaminase-like
HPS43_11970	COG0709	Synthesizes selenophosphate from selenide and ATP
HPS43_12005	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_12010	COG3284	Transcriptional regulator
HPS43_12015	COG0134	indole-3-glycerol-phosphate synthase activity
HPS43_12020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPS43_12025	COG0512	Glutamine amidotransferase of anthranilate synthase
HPS43_12035	COG0546	phosphoglycolate phosphatase activity
HPS43_12040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPS43_12045	COG2967	ApaG domain
HPS43_12055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS43_12060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPS43_12070	COG0037	tRNA processing
HPS43_12085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS43_12100	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_12105	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_12120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPS43_12145	COG3473	Maleate cis-trans isomerase
HPS43_12150	COG0583	DNA-binding transcription factor activity
HPS43_12165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS43_12175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS43_12180	COG1024	Enoyl-CoA hydratase
HPS43_12195	COG0356	it plays a direct role in the translocation of protons across the membrane
HPS43_12210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPS43_12215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPS43_12220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPS43_12230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPS43_12240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPS43_12245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPS43_12250	COG0210	DNA helicase
HPS43_12265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPS43_12280	COG2171	N-acyltransferase activity
HPS43_12290	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPS43_12300	COG4608	Belongs to the ABC transporter superfamily
HPS43_12305	COG0444	Belongs to the ABC transporter superfamily
HPS43_12315	COG0601	transmembrane transport
HPS43_12320	COG0747	negative chemotaxis
HPS43_12325	COG2988	succinylglutamate desuccinylase activity
HPS43_12335	COG0583	DNA-binding transcription factor activity
HPS43_12340	COG0747	negative chemotaxis
HPS43_12350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPS43_12355	COG1024	Enoyl-CoA hydratase
HPS43_12360	COG1024	Enoyl-CoA hydratase
HPS43_12370	COG1309	transcriptional regulator
HPS43_12385	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_12400	COG2814	Major facilitator Superfamily
HPS43_12415	COG1764	response to oxidative stress
HPS43_12420	COG0583	DNA-binding transcription factor activity
HPS43_12430	COG1595	DNA-templated transcription, initiation
HPS43_12435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPS43_12440	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_12455	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS43_12475	COG1129	ABC transporter
HPS43_12490	COG1802	Transcriptional regulator
HPS43_12500	COG0583	DNA-binding transcription factor activity
HPS43_12510	COG2988	succinylglutamate desuccinylase activity
HPS43_12520	COG2918	glutathione biosynthetic process
HPS43_12550	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPS43_12555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS43_12565	COG2721	sulfolactate sulfo-lyase activity
HPS43_12570	COG2721	sulfolactate sulfo-lyase activity
HPS43_12575	COG2188	Transcriptional regulator
HPS43_12580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS43_12585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS43_12585	COG2813	Specifically methylates the guanine in position
HPS43_12590	COG2223	nitrite transmembrane transporter activity
HPS43_12600	COG2860	membrane
HPS43_12605	COG1802	Transcriptional regulator
HPS43_12615	COG1984	allophanate hydrolase subunit 2
HPS43_12620	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPS43_12630	COG0583	DNA-binding transcription factor activity
HPS43_12640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS43_12655	COG2132	Multicopper oxidase
HPS43_12680	COG0745	RESPONSE REGULATOR receiver
HPS43_12685	COG2226	methyltransferase
HPS43_12700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPS43_12710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPS43_12720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPS43_12725	COG0351	phosphomethylpyrimidine kinase
HPS43_12730	COG2022	thiamine diphosphate biosynthetic process
HPS43_12735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPS43_12740	COG4771	TonB-dependent receptor
HPS43_12750	COG2186	Transcriptional regulator
HPS43_12765	COG1063	alcohol dehydrogenase
HPS43_12775	COG0765	amino acid transport
HPS43_12780	COG1126	abc transporter atp-binding protein
HPS43_12785	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_12790	COG0246	Mannitol dehydrogenase
HPS43_12805	COG1194	a g-specific adenine glycosylase
HPS43_12830	COG2177	Part of the ABC transporter FtsEX involved in
HPS43_12835	COG2884	Cell division ATP-binding protein ftsE
HPS43_12840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_12845	COG4597	amino acid ABC transporter
HPS43_12850	COG0765	amino acid transport
HPS43_12855	COG1126	abc transporter atp-binding protein
HPS43_12880	COG1129	ABC transporter
HPS43_12885	COG4177	L-phenylalanine transmembrane transporter activity
HPS43_12900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS43_12905	COG2081	HI0933 family
HPS43_12915	COG0077	Prephenate dehydratase
HPS43_12915	COG1605	Chorismate mutase
HPS43_12950	COG0477	Major facilitator Superfamily
HPS43_12960	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HPS43_12965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPS43_12985	COG0237	dephospho-CoA kinase activity
HPS43_12990	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPS43_13020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_13025	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS43_13040	COG3833	ABC-type maltose transport systems, permease component
HPS43_13045	COG1175	transmembrane transport
HPS43_13050	COG3842	ATPase activity
HPS43_13070	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HPS43_13105	COG0410	ABC transporter
HPS43_13125	COG3706	GGDEF domain
HPS43_13140	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_13145	COG1024	Enoyl-CoA hydratase
HPS43_13185	COG4638	Rieske (2fe-2S)
HPS43_13190	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HPS43_13195	COG1335	isochorismatase
HPS43_13200	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_13210	COG0741	lytic transglycosylase activity
HPS43_13215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPS43_13220	COG0352	thiamine-phosphate diphosphorylase activity
HPS43_13235	COG1678	Uncharacterized ACR, COG1678
HPS43_13240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPS43_13270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS43_13275	COG0436	Aminotransferase
HPS43_13280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_13295	COG1126	abc transporter atp-binding protein
HPS43_13300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPS43_13310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPS43_13315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPS43_13325	COG3842	ATPase activity
HPS43_13330	COG1175	transmembrane transport
HPS43_13340	COG0642	Histidine kinase
HPS43_13350	COG0557	exoribonuclease II activity
HPS43_13355	COG3150	esterase
HPS43_13360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPS43_13365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_13370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPS43_13375	COG0511	ligase activity, forming carbon-carbon bonds
HPS43_13380	COG0439	Biotin carboxylase
HPS43_13385	COG2264	protein methyltransferase activity
HPS43_13395	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPS43_13395	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPS43_13420	COG1696	Membrane protein involved in D-alanine export
HPS43_13425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPS43_13455	COG1522	sequence-specific DNA binding
HPS43_13460	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_13470	COG0583	DNA-binding transcription factor activity
HPS43_13485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPS43_13490	COG1042	CoA-binding domain protein
HPS43_13490	COG0045	succinate-CoA ligase (ADP-forming) activity
HPS43_13490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPS43_13495	COG1335	isochorismatase
HPS43_13500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_13505	COG1116	anion transmembrane transporter activity
HPS43_13520	COG3028	Belongs to the UPF0307 family
HPS43_13525	COG0312	modulator of DNA gyrase
HPS43_13530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPS43_13540	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_13545	COG4177	L-phenylalanine transmembrane transporter activity
HPS43_13560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPS43_13565	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPS43_13570	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPS43_13580	COG0316	Belongs to the HesB IscA family
HPS43_13595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPS43_13605	COG1280	lysine exporter protein (LysE YggA)
HPS43_13610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPS43_13615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPS43_13630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPS43_13630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPS43_13645	COG2766	serine protein kinase
HPS43_13650	COG2718	Belongs to the UPF0229 family
HPS43_13655	COG2719	SpoVR family
HPS43_13665	COG0583	DNA-binding transcription factor activity
HPS43_13670	COG1942	4-Oxalocrotonate Tautomerase
HPS43_13680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPS43_13690	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_13735	COG4789	Type iii secretion
HPS43_13805	COG4669	(LipO)protein
HPS43_13835	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPS43_13840	COG4790	Type iii secretion
HPS43_13845	COG4794	Type iii secretion
HPS43_13850	COG4791	protein targeting
HPS43_13885	COG2770	Histidine kinase
HPS43_13885	COG2208	phosphoserine phosphatase activity
HPS43_13895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPS43_13900	COG2172	sigma factor antagonist activity
HPS43_13905	COG1366	Belongs to the anti-sigma-factor antagonist family
HPS43_13945	COG0741	lytic transglycosylase activity
HPS43_13945	COG1388	LysM domain
HPS43_13950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPS43_13955	COG2226	methyltransferase
HPS43_13960	COG0328	RNA-DNA hybrid ribonuclease activity
HPS43_13970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_13975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPS43_13990	COG1671	Belongs to the UPF0178 family
HPS43_14005	COG0786	glutamate:sodium symporter activity
HPS43_14015	COG0463	Glycosyl transferase, family 2
HPS43_14020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPS43_14035	COG0583	DNA-binding transcription factor activity
HPS43_14055	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_14075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_14085	COG0583	DNA-binding transcription factor activity
HPS43_14095	COG1346	cytolysis
HPS43_14105	COG0697	spore germination
HPS43_14110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_14125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPS43_14135	COG1522	sequence-specific DNA binding
HPS43_14150	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPS43_14155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_14170	COG0823	Involved in the tonB-independent uptake of proteins
HPS43_14180	COG0848	biopolymer transport protein
HPS43_14185	COG0811	peptide transport
HPS43_14190	COG0824	Thioesterase
HPS43_14195	COG0442	prolyl-tRNA aminoacylation
HPS43_14225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS43_14240	COG2084	Dehydrogenase
HPS43_14245	COG0405	Gamma-glutamyltransferase
HPS43_14285	COG0129	dihydroxy-acid dehydratase activity
HPS43_14290	COG4654	Cytochrome c, class I
HPS43_14295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS43_14305	COG1522	sequence-specific DNA binding
HPS43_14345	COG0583	DNA-binding transcription factor activity
HPS43_14355	COG1473	amidohydrolase
HPS43_14360	COG0418	dihydroorotase activity
HPS43_14375	COG2001	Belongs to the MraZ family
HPS43_14380	COG0275	rRNA processing
HPS43_14385	COG3116	cell division
HPS43_14395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPS43_14400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPS43_14405	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPS43_14415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPS43_14420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPS43_14425	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPS43_14430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPS43_14440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPS43_14445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPS43_14455	COG0739	heme binding
HPS43_14460	COG0653	protein targeting
HPS43_14475	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_14480	COG0028	Belongs to the TPP enzyme family
HPS43_14490	COG0300	oxidoreductase activity
HPS43_14495	COG1522	sequence-specific DNA binding
HPS43_14510	COG2239	Acts as a magnesium transporter
HPS43_14520	COG2855	membrane
HPS43_14525	COG0583	DNA-binding transcription factor activity
HPS43_14530	COG1473	amidohydrolase
HPS43_14535	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_14540	COG0483	inositol monophosphate 1-phosphatase activity
HPS43_14545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_14545	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPS43_14550	COG1501	Belongs to the glycosyl hydrolase 31 family
HPS43_14555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPS43_14560	COG2011	ABC-type metal ion transport system permease component
HPS43_14575	COG1595	DNA-templated transcription, initiation
HPS43_14580	COG3712	iron ion homeostasis
HPS43_14600	COG0840	transmembrane signaling receptor activity
HPS43_14605	COG0583	DNA-binding transcription factor activity
HPS43_14615	COG0735	belongs to the Fur family
HPS43_14640	COG2818	Glycosylase
HPS43_14645	COG1368	sulfuric ester hydrolase activity
HPS43_14650	COG2982	Protein involved in outer membrane biogenesis
HPS43_14665	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_14680	COG2124	cytochrome p450
HPS43_14730	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPS43_14745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS43_14760	COG3178	'Phosphotransferase
HPS43_14770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS43_14775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPS43_14780	COG1929	Belongs to the glycerate kinase type-1 family
HPS43_14785	COG0469	pyruvate kinase activity
HPS43_14790	COG0700	Nucleoside recognition
HPS43_14795	COG1960	acyl-CoA dehydrogenase activity
HPS43_14800	COG0242	peptide deformylase activity
HPS43_14820	COG0204	Acyl-transferase
HPS43_14825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPS43_14830	COG0751	glycine-tRNA ligase activity
HPS43_14835	COG0752	glycyl-tRNA synthetase alpha subunit
HPS43_14840	COG1024	Enoyl-CoA hydratase
HPS43_14860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_14865	COG2030	dehydratase
HPS43_14870	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_14885	COG2070	2-Nitropropane dioxygenase
HPS43_14895	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_14900	COG0183	Belongs to the thiolase family
HPS43_14910	COG1960	acyl-CoA dehydrogenase activity
HPS43_14920	COG1024	Enoyl-CoA hydratase
HPS43_14930	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HPS43_14940	COG2301	Belongs to the HpcH HpaI aldolase family
HPS43_14945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPS43_14955	COG0617	tRNA 3'-terminal CCA addition
HPS43_14970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPS43_14980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPS43_14985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPS43_14990	COG0586	Pfam SNARE associated Golgi protein
HPS43_15000	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPS43_15005	COG0802	atpase or kinase
HPS43_15020	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_15040	COG0531	amino acid
HPS43_15045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_15050	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_15055	COG1960	acyl-CoA dehydrogenase activity
HPS43_15060	COG0583	DNA-binding transcription factor activity
HPS43_15065	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS43_15085	COG2175	clavaminate synthase activity
HPS43_15100	COG0583	DNA-binding transcription factor activity
HPS43_15110	COG0579	oxidoreductase
HPS43_15120	COG0259	pyridoxamine-phosphate oxidase activity
HPS43_15135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_15140	COG0577	efflux transmembrane transporter activity
HPS43_15140	COG1136	(ABC) transporter
HPS43_15145	COG1538	Outer membrane efflux protein
HPS43_15150	COG0583	DNA-binding transcription factor activity
HPS43_15170	COG0577	efflux transmembrane transporter activity
HPS43_15170	COG1136	(ABC) transporter
HPS43_15200	COG1136	(ABC) transporter
HPS43_15205	COG0577	efflux transmembrane transporter activity
HPS43_15205	COG1136	(ABC) transporter
HPS43_15215	COG1566	PFAM secretion protein HlyD family protein
HPS43_15220	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPS43_15255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPS43_15265	COG0800	Aldolase
HPS43_15280	COG0463	Glycosyl transferase, family 2
HPS43_15280	COG1216	Glycosyl transferase, family 2
HPS43_15305	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_15310	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HPS43_15330	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HPS43_15335	COG4638	Rieske (2fe-2S)
HPS43_15360	COG0747	negative chemotaxis
HPS43_15370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_15375	COG0444	Belongs to the ABC transporter superfamily
HPS43_15380	COG4608	Belongs to the ABC transporter superfamily
HPS43_15400	COG2746	aminoglycoside 3-N-acetyltransferase activity
HPS43_15405	COG0488	(ABC) transporter
HPS43_15430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPS43_15435	COG2894	cell division
HPS43_15440	COG0850	regulation of cytokinetic process
HPS43_15445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPS43_15455	COG1294	oxidase, subunit
HPS43_15460	COG0514	ATP-dependent DNA helicase (RecQ)
HPS43_15470	COG0745	RESPONSE REGULATOR receiver
HPS43_15475	COG4191	Histidine kinase
HPS43_15480	COG2255	four-way junction helicase activity
HPS43_15490	COG1090	epimerase
HPS43_15495	COG0632	four-way junction helicase activity
HPS43_15520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS43_15530	COG0006	proline dipeptidase activity
HPS43_15545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPS43_15550	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_15565	COG4783	chaperone-mediated protein folding
HPS43_15605	COG2814	Major facilitator Superfamily
HPS43_15610	COG4771	TonB-dependent receptor
HPS43_15620	COG0513	Belongs to the DEAD box helicase family
HPS43_15635	COG1546	Belongs to the CinA family
HPS43_15635	COG1058	Belongs to the CinA family
HPS43_15640	COG1414	Transcriptional regulator
HPS43_15655	COG0167	dihydroorotate dehydrogenase activity
HPS43_15660	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPS43_15665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPS43_15785	COG0629	single-stranded DNA binding
HPS43_15790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPS43_15805	COG0789	Transcriptional regulator
HPS43_15815	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPS43_15900	COG0431	NADPH-dependent FMN reductase
HPS43_15905	COG1393	Belongs to the ArsC family
HPS43_15910	COG0798	PFAM Bile acid sodium symporter
HPS43_15920	COG0640	Transcriptional regulator
HPS43_15990	COG1569	PIN domain
HPS43_15995	COG3311	Transcriptional regulator
HPS43_16050	COG2003	Belongs to the UPF0758 family
HPS43_16115	COG0789	Transcriptional regulator
HPS43_16150	COG2326	polyphosphate kinase activity
HPS43_16155	COG2217	Heavy metal translocating P-type atpase
HPS43_16170	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HPS43_16180	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPS43_16185	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPS43_16205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS43_16225	COG0300	oxidoreductase activity
HPS43_16230	COG1309	transcriptional regulator
HPS43_16235	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HPS43_16240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS43_16245	COG0789	Transcriptional regulator
HPS43_16250	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPS43_16270	COG5002	protein histidine kinase activity
HPS43_16275	COG0745	RESPONSE REGULATOR receiver
HPS43_16280	COG2132	Multicopper oxidase
HPS43_16320	COG0583	DNA-binding transcription factor activity
HPS43_16325	COG1396	sequence-specific DNA binding
HPS43_16350	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_16365	COG0582	viral genome integration into host DNA
HPS43_16385	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPS43_16390	COG0735	belongs to the Fur family
HPS43_16395	COG0497	DNA recombination
HPS43_16405	COG1420	regulation of RNA biosynthetic process
HPS43_16410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPS43_16420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPS43_16430	COG0443	Heat shock 70 kDa protein
HPS43_16435	COG0484	heat shock protein binding
HPS43_16445	COG0612	Peptidase, M16
HPS43_16470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPS43_16505	COG0840	transmembrane signaling receptor activity
HPS43_16510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_16525	COG0745	RESPONSE REGULATOR receiver
HPS43_16530	COG2205	protein histidine kinase activity
HPS43_16535	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HPS43_16540	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HPS43_16545	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HPS43_16560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPS43_16570	COG1193	negative regulation of DNA recombination
HPS43_16575	COG0492	ferredoxin-NADP+ reductase activity
HPS43_16580	COG1674	ftsk spoiiie
HPS43_16585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPS43_16590	COG0251	oxidation-reduction process
HPS43_16595	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS43_16600	COG0517	IMP dehydrogenase activity
HPS43_16600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPS43_16620	COG0601	transmembrane transport
HPS43_16635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPS43_16640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPS43_16645	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPS43_16690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_16700	COG4774	siderophore transport
HPS43_16705	COG4607	ABC-type enterochelin transport system periplasmic component
HPS43_16710	COG4604	ABC transporter, ATP-binding protein
HPS43_16715	COG4605	iron ion homeostasis
HPS43_16720	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_16750	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_16755	COG3022	response to hydroperoxide
HPS43_16760	COG1289	transmembrane transporter activity
HPS43_16765	COG0028	Belongs to the TPP enzyme family
HPS43_16770	COG0440	acetolactate synthase activity
HPS43_16775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPS43_16780	COG1183	phosphatidylcholine synthase activity
HPS43_16790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPS43_16795	COG1185	polyribonucleotide nucleotidyltransferase activity
HPS43_16810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPS43_16820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPS43_16830	COG2207	Transcriptional regulator
HPS43_16855	COG0149	triose-phosphate isomerase activity
HPS43_16860	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPS43_16880	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HPS43_16885	COG1959	2 iron, 2 sulfur cluster binding
HPS43_16890	COG2814	Major facilitator Superfamily
HPS43_16905	COG0840	transmembrane signaling receptor activity
HPS43_16925	COG1910	domain protein
HPS43_16960	COG1116	anion transmembrane transporter activity
HPS43_16990	COG1595	DNA-templated transcription, initiation
HPS43_17005	COG1595	DNA-templated transcription, initiation
HPS43_17010	COG3712	iron ion homeostasis
HPS43_17035	COG0642	Histidine kinase
HPS43_17045	COG2851	Citrate transporter
HPS43_17050	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_17070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPS43_17075	COG4191	Histidine kinase
HPS43_17075	COG0784	Response regulator, receiver
HPS43_17090	COG3604	Transcriptional regulator
HPS43_17095	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HPS43_17100	COG3813	Protein conserved in bacteria
HPS43_17105	COG2354	Protein conserved in bacteria
HPS43_17120	COG4772	TonB-dependent receptor
HPS43_17125	COG1522	sequence-specific DNA binding
HPS43_17145	COG4172	Belongs to the ABC transporter superfamily
HPS43_17155	COG0747	negative chemotaxis
HPS43_17175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_17190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPS43_17195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_17200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_17220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_17230	COG1309	transcriptional regulator
HPS43_17235	COG0583	DNA-binding transcription factor activity
HPS43_17255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS43_17280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_17285	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS43_17290	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS43_17295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS43_17300	COG0649	NAD binding
HPS43_17305	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HPS43_17315	COG1034	ATP synthesis coupled electron transport
HPS43_17320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HPS43_17325	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS43_17335	COG0713	ATP synthesis coupled electron transport
HPS43_17350	COG1007	ATP synthesis coupled electron transport
HPS43_17360	COG4774	siderophore transport
HPS43_17365	COG0560	Phosphoserine phosphatase
HPS43_17370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPS43_17375	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPS43_17380	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPS43_17390	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS43_17395	COG0450	alkyl hydroperoxide reductase
HPS43_17400	COG2205	protein histidine kinase activity
HPS43_17405	COG0745	RESPONSE REGULATOR receiver
HPS43_17410	COG1214	PFAM Peptidase M22, glycoprotease
HPS43_17415	COG1573	uracil-dna glycosylase
HPS43_17420	COG0477	Major facilitator Superfamily
HPS43_17425	COG1196	nuclear chromosome segregation
HPS43_17435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPS43_17440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS43_17450	COG2917	probably involved in intracellular septation
HPS43_17455	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS43_17460	COG1122	ATPase activity
HPS43_17465	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPS43_17470	COG1268	BioY protein
HPS43_17505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPS43_17540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPS43_17545	COG2878	Part of a membrane complex involved in electron transport
HPS43_17560	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPS43_17565	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPS43_17570	COG0251	oxidation-reduction process
HPS43_17580	COG3228	Belongs to the MtfA family
HPS43_17585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPS43_17595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS43_17605	COG0159	tryptophan synthase activity
HPS43_17610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPS43_17615	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HPS43_17620	COG1530	ribonuclease E activity
HPS43_17625	COG0564	pseudouridine synthase activity
HPS43_17630	COG0546	phosphoglycolate phosphatase activity
HPS43_17635	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPS43_17640	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HPS43_17655	COG0424	maF-like protein
HPS43_17665	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPS43_17675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS43_17680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPS43_17690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPS43_17695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPS43_17720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS43_17725	COG0481	GTPase activity
HPS43_17730	COG0681	Belongs to the peptidase S26 family
HPS43_17735	COG0571	ribonuclease III activity
HPS43_17740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPS43_17745	COG1381	Involved in DNA repair and RecF pathway recombination
HPS43_17795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPS43_17820	COG0583	DNA-binding transcription factor activity
HPS43_17830	COG0791	NLP P60 protein
HPS43_17840	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HPS43_17850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPS43_17855	COG0697	spore germination
HPS43_17860	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPS43_17885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_17910	COG2153	protein acetylation
HPS43_17920	COG1446	asparaginase
HPS43_17925	COG4172	Belongs to the ABC transporter superfamily
HPS43_17930	COG0747	negative chemotaxis
HPS43_17965	COG0504	CTP synthase activity
HPS43_17975	COG0148	phosphopyruvate hydratase activity
HPS43_17990	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPS43_18000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPS43_18055	COG0039	L-malate dehydrogenase activity
HPS43_18060	COG2188	Transcriptional regulator
HPS43_18065	COG2009	succinate dehydrogenase
HPS43_18070	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPS43_18075	COG1053	succinate dehydrogenase
HPS43_18080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPS43_18085	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPS43_18090	COG0372	Belongs to the citrate synthase family
HPS43_18105	COG0280	phosphate acetyltransferase
HPS43_18105	COG0281	malic enzyme
HPS43_18115	COG1297	OPT oligopeptide transporter protein
HPS43_18120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS43_18135	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HPS43_18140	COG1522	sequence-specific DNA binding
HPS43_18145	COG0567	Dehydrogenase, E1 component
HPS43_18150	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPS43_18155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPS43_18160	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPS43_18165	COG1595	DNA-templated transcription, initiation
HPS43_18170	COG3712	iron ion homeostasis
HPS43_18175	COG4774	siderophore transport
HPS43_18210	COG2183	response to ionizing radiation
HPS43_18215	COG1199	ATP-dependent helicase activity
HPS43_18225	COG0564	pseudouridine synthase activity
HPS43_18235	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPS43_18240	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_18245	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HPS43_18270	COG2831	hemolysin activation secretion protein
HPS43_18295	COG2823	Periplasmic or secreted lipoprotein
HPS43_18305	COG3237	CsbD-like
HPS43_18310	COG0189	ligase activity
HPS43_18310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPS43_18315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPS43_18315	COG0189	ligase activity
HPS43_18320	COG1132	(ABC) transporter
HPS43_18335	COG2833	Protein of unknown function (DUF455)
HPS43_18340	COG2258	MOSC domain
HPS43_18345	COG2951	lytic endotransglycosylase activity
HPS43_18360	COG1960	acyl-CoA dehydrogenase activity
HPS43_18370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPS43_18380	COG1696	Membrane protein involved in D-alanine export
HPS43_18400	COG1215	transferase activity, transferring glycosyl groups
HPS43_18410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPS43_18435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPS43_18450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPS43_18460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPS43_18470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HPS43_18475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPS43_18495	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPS43_18500	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPS43_18505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_18535	COG2951	lytic endotransglycosylase activity
HPS43_18540	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPS43_18565	COG2985	domain, Protein
HPS43_18570	COG1960	acyl-CoA dehydrogenase activity
HPS43_18575	COG0450	alkyl hydroperoxide reductase
HPS43_18585	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HPS43_18590	COG4208	sulfate ABC transporter
HPS43_18600	COG0175	sulfate reduction
HPS43_18630	COG0335	large ribosomal subunit rRNA binding
HPS43_18635	COG0494	nUDIX hydrolase
HPS43_18640	COG1162	GTPase activity
HPS43_18645	COG0501	Belongs to the peptidase M48B family
HPS43_18650	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPS43_18655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPS43_18660	COG3327	negative regulation of DNA-templated transcription, initiation
HPS43_18665	COG3396	Phenylacetate-CoA oxygenase
HPS43_18670	COG3460	Phenylacetate-CoA oxygenase
HPS43_18675	COG3396	Phenylacetate-CoA oxygenase
HPS43_18680	COG2151	metal-sulfur cluster biosynthetic enzyme
HPS43_18685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPS43_18690	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_18695	COG1024	Enoyl-CoA hydratase
HPS43_18700	COG2050	protein possibly involved in aromatic compounds catabolism
HPS43_18710	COG0534	Mate efflux family protein
HPS43_18725	COG3483	tryptophan 2,3-dioxygenase activity
HPS43_18730	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HPS43_18735	COG2003	Belongs to the UPF0758 family
HPS43_18745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPS43_18750	COG0625	glutathione transferase activity
HPS43_18755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS43_18760	COG0642	Histidine kinase
HPS43_18780	COG0523	cobalamin synthesis protein
HPS43_18785	COG0523	cobalamin synthesis protein
HPS43_18790	COG0583	DNA-binding transcription factor activity
HPS43_18805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HPS43_18810	COG1187	pseudouridine synthase activity
HPS43_18815	COG0779	Required for maturation of 30S ribosomal subunits
HPS43_18820	COG2251	uridine kinase activity
HPS43_18820	COG0195	Participates in both transcription termination and antitermination
HPS43_18825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPS43_18830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPS43_18835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPS43_18860	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_18865	COG1473	amidohydrolase
HPS43_18870	COG1611	Belongs to the LOG family
HPS43_18885	COG0412	Dienelactone hydrolase
HPS43_18895	COG1760	l-serine dehydratase
HPS43_18900	COG0501	Belongs to the peptidase M48B family
HPS43_18920	COG0583	DNA-binding transcription factor activity
HPS43_18925	COG3842	ATPase activity
HPS43_18935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPS43_18940	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS43_18960	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_18970	COG1722	exodeoxyribonuclease VII activity
HPS43_18975	COG0142	geranyltranstransferase activity
HPS43_18985	COG1469	GTP cyclohydrolase I activity
HPS43_18990	COG3739	integral membrane protein
HPS43_18995	COG0360	Binds together with S18 to 16S ribosomal RNA
HPS43_19000	COG2965	DNA replication, synthesis of RNA primer
HPS43_19005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPS43_19010	COG0359	binds to the 23S rRNA
HPS43_19020	COG0305	Participates in initiation and elongation during chromosome replication
HPS43_19035	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPS43_19070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_19120	COG0540	Belongs to the ATCase OTCase family
HPS43_19145	COG0642	Histidine kinase
HPS43_19155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPS43_19160	COG2137	regulation of response to DNA damage stimulus
HPS43_19185	COG0045	succinate-CoA ligase (ADP-forming) activity
HPS43_19190	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPS43_19195	COG0861	Integral membrane protein TerC family
HPS43_19200	COG0861	Integral membrane protein TerC family
HPS43_19205	COG0181	hydroxymethylbilane synthase activity
HPS43_19225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPS43_19235	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_19265	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_19285	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPS43_19290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPS43_19300	COG0436	Aminotransferase
HPS43_19320	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HPS43_19325	COG0308	aminopeptidase N
HPS43_19340	COG0312	modulator of DNA gyrase
HPS43_19345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPS43_19350	COG0277	FAD linked oxidase domain protein
HPS43_19355	COG0277	FAD linked oxidase domain protein
HPS43_19360	COG0277	FAD linked oxidase domain protein
HPS43_19365	COG0247	lactate metabolic process
HPS43_19395	COG0583	DNA-binding transcription factor activity
HPS43_19400	COG0482	sulfurtransferase activity
HPS43_19405	COG0730	response to heat
HPS43_19410	COG0625	glutathione transferase activity
HPS43_19420	COG3909	cytochrome
HPS43_19460	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HPS43_19575	COG0697	spore germination
HPS43_19610	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HPS43_19620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS43_19625	COG0069	glutamate synthase activity
HPS43_19630	COG2391	methyltransferase activity
HPS43_19635	COG0679	Auxin Efflux Carrier
HPS43_19665	COG0557	exoribonuclease II activity
HPS43_19670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPS43_19680	COG3128	pkhd-type hydroxylase
HPS43_19685	COG0776	regulation of translation
HPS43_19710	COG0745	RESPONSE REGULATOR receiver
HPS43_19715	COG0642	Histidine kinase
HPS43_19720	COG3158	transport of potassium into the cell
HPS43_19725	COG0137	argininosuccinate synthase activity
HPS43_19730	COG0583	DNA-binding transcription factor activity
HPS43_19735	COG3618	amidohydrolase
HPS43_19755	COG0596	Alpha beta hydrolase
HPS43_19755	COG2945	thiolester hydrolase activity
HPS43_19760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPS43_19765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPS43_19785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_19790	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPS43_19800	COG3642	lipopolysaccharide core region biosynthetic process
HPS43_19810	COG3842	ATPase activity
HPS43_19815	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS43_19820	COG1177	transmembrane transport
HPS43_19840	COG1322	Protein conserved in bacteria
HPS43_19850	COG1960	acyl-CoA dehydrogenase activity
HPS43_19860	COG0704	Plays a role in the regulation of phosphate uptake
HPS43_19870	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPS43_19875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPS43_19875	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPS43_19880	COG1643	Atp-dependent helicase
HPS43_19885	COG0395	ABC-type sugar transport system, permease component
HPS43_19890	COG1116	anion transmembrane transporter activity
HPS43_19905	COG0438	transferase activity, transferring glycosyl groups
HPS43_19910	COG0726	polysaccharide deacetylase
HPS43_19925	COG0726	polysaccharide deacetylase
HPS43_19950	COG1132	(ABC) transporter
HPS43_19955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPS43_19955	COG0475	glutathione-regulated potassium exporter activity
HPS43_19965	COG3706	GGDEF domain
HPS43_19965	COG2203	Gaf domain
HPS43_19965	COG4251	negative regulation of phosphorylation
HPS43_19965	COG5001	Diguanylate cyclase
HPS43_19975	COG1530	ribonuclease E activity
HPS43_20005	COG2204	response regulator
HPS43_20010	COG4191	Histidine kinase
HPS43_20015	COG1301	dicarboxylic acid transport
HPS43_20025	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPS43_20030	COG0799	negative regulation of ribosome biogenesis
HPS43_20035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPS43_20045	COG0151	Belongs to the GarS family
HPS43_20050	COG0217	transcriptional regulatory protein
HPS43_20055	COG0433	COG0433 Predicted ATPase
HPS43_20060	COG0473	3-isopropylmalate dehydrogenase activity
HPS43_20070	COG2814	Major facilitator Superfamily
HPS43_20075	COG1566	PFAM secretion protein HlyD family protein
HPS43_20085	COG1846	Transcriptional regulator
HPS43_20115	COG3391	amine dehydrogenase activity
HPS43_20125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPS43_20145	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPS43_20150	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPS43_20160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPS43_20185	COG1309	transcriptional regulator
HPS43_20190	COG2311	Membrane
HPS43_20195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPS43_20220	COG0662	Cupin 2, conserved barrel domain protein
HPS43_20225	COG5285	phytanoyl-CoA dioxygenase
HPS43_20230	COG0633	Ferredoxin
HPS43_20230	COG3217	Mosc domain protein beta barrel domain protein
HPS43_20235	COG2076	Multidrug Resistance protein
HPS43_20250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_20265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPS43_20270	COG0425	Belongs to the sulfur carrier protein TusA family
HPS43_20280	COG0228	four-way junction DNA binding
HPS43_20290	COG0336	Belongs to the RNA methyltransferase TrmD family
HPS43_20295	COG1396	sequence-specific DNA binding
HPS43_20300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_20305	COG0765	amino acid transport
HPS43_20315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_20320	COG0525	valine-tRNA ligase activity
HPS43_20325	COG0105	UTP biosynthetic process
HPS43_20330	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPS43_20350	COG2976	Protein conserved in bacteria
HPS43_20355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPS43_20360	COG1160	GTP binding
HPS43_20365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPS43_20370	COG1923	regulation of RNA biosynthetic process
HPS43_20375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPS43_20380	COG0330	HflC and HflK could
HPS43_20385	COG0330	HflC and HflK could
HPS43_20390	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HPS43_20395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPS43_20400	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPS43_20405	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPS43_20425	COG0438	transferase activity, transferring glycosyl groups
HPS43_20435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPS43_20435	COG2755	lipolytic protein G-D-S-L family
HPS43_20465	COG4964	Belongs to the GSP D family
HPS43_20495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPS43_20505	COG1295	ribonuclease BN
HPS43_20515	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPS43_20540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPS43_20600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_20605	COG2274	protein secretion by the type I secretion system
HPS43_20615	COG1538	Outer membrane efflux protein
HPS43_20635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPS43_20645	COG0101	tRNA pseudouridine synthase activity
HPS43_20650	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPS43_20670	COG0596	Alpha beta hydrolase
HPS43_20705	COG0129	dihydroxy-acid dehydratase activity
HPS43_20710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_20715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS43_20720	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPS43_20725	COG1609	Transcriptional regulator
HPS43_20745	COG4172	Belongs to the ABC transporter superfamily
HPS43_20750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_20755	COG0601	transmembrane transport
HPS43_20765	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_20795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPS43_20800	COG2197	response regulator
HPS43_20810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPS43_20815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPS43_20830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPS43_20835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPS43_20840	COG0004	ammonium transporteR
HPS43_20845	COG0347	Belongs to the P(II) protein family
HPS43_20855	COG2960	long-chain fatty acid transporting porin activity
HPS43_20865	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPS43_20870	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPS43_20875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPS43_20880	COG0072	phenylalanine-tRNA ligase activity
HPS43_20880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS43_20910	COG2814	Major facilitator Superfamily
HPS43_20935	COG0384	phenazine biosynthesis protein PhzF
HPS43_20940	COG0456	acetyltransferase
HPS43_20975	COG1522	sequence-specific DNA binding
HPS43_21005	COG0583	DNA-binding transcription factor activity
HPS43_21010	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_21035	COG1116	anion transmembrane transporter activity
HPS43_21065	COG5265	(ABC) transporter
HPS43_21070	COG0656	L-ascorbic acid biosynthetic process
HPS43_21085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPS43_21095	COG4977	sequence-specific DNA binding
HPS43_21095	COG1917	Cupin 2, conserved barrel domain protein
HPS43_21100	COG2223	nitrite transmembrane transporter activity
HPS43_21110	COG1215	transferase activity, transferring glycosyl groups
HPS43_21115	COG0726	polysaccharide deacetylase
HPS43_21115	COG1649	PFAM Uncharacterised BCR, COG1649
HPS43_21120	COG0457	Tetratricopeptide repeat
HPS43_21125	COG3706	GGDEF domain
HPS43_21150	COG1610	YqeY-like protein
HPS43_21155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPS43_21160	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_21200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPS43_21210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPS43_21215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPS43_21240	COG1959	2 iron, 2 sulfur cluster binding
HPS43_21245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_21250	COG0697	spore germination
HPS43_21275	COG0583	DNA-binding transcription factor activity
HPS43_21285	COG0625	glutathione transferase activity
HPS43_21300	COG2814	Major facilitator Superfamily
HPS43_21305	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HPS43_21320	COG1960	acyl-CoA dehydrogenase activity
HPS43_21325	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_21365	COG3245	cytochrome
HPS43_21370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPS43_21385	COG1280	lysine exporter protein (LysE YggA)
HPS43_21400	COG0697	spore germination
HPS43_21405	COG0697	spore germination
HPS43_21420	COG0534	Mate efflux family protein
HPS43_21425	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPS43_21430	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_21440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPS43_21445	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HPS43_21455	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_21490	COG2207	Transcriptional regulator
HPS43_21505	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_21510	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_21515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS43_21520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS43_21530	COG1304	FMN binding
HPS43_21550	COG3712	iron ion homeostasis
HPS43_21555	COG1595	DNA-templated transcription, initiation
HPS43_21580	COG1401	restriction endodeoxyribonuclease activity
HPS43_21610	COG3088	subunit of a heme lyase
HPS43_21615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_21625	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPS43_21640	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPS43_21645	COG4133	protoheme IX ABC transporter activity
HPS43_21665	COG3381	protein complex oligomerization
HPS43_21685	COG4235	cytochrome complex assembly
HPS43_21695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_21705	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPS43_21725	COG4133	protoheme IX ABC transporter activity
HPS43_21730	COG3005	denitrification pathway
HPS43_21735	COG3043	anaerobic respiration
HPS43_21755	COG3246	L-lysine catabolic process to acetate
HPS43_21760	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_21765	COG0583	DNA-binding transcription factor activity
HPS43_21775	COG0129	dihydroxy-acid dehydratase activity
HPS43_21780	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_21785	COG5001	Diguanylate cyclase
HPS43_21790	COG1024	Enoyl-CoA hydratase
HPS43_21820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_21830	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HPS43_21835	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_21840	COG0583	DNA-binding transcription factor activity
HPS43_21845	COG2610	gluconate transmembrane transporter activity
HPS43_21885	COG0235	Class ii aldolase
HPS43_21890	COG0477	Major facilitator Superfamily
HPS43_21905	COG2188	Transcriptional regulator
HPS43_21910	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_21950	COG1280	lysine exporter protein (LysE YggA)
HPS43_21955	COG5265	(ABC) transporter
HPS43_21965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_21980	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_21985	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_22020	COG0583	DNA-binding transcription factor activity
HPS43_22030	COG0583	DNA-binding transcription factor activity
HPS43_22040	COG0583	DNA-binding transcription factor activity
HPS43_22065	COG2226	methyltransferase
HPS43_22075	COG2814	Major facilitator Superfamily
HPS43_22080	COG0154	amidase activity
HPS43_22115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPS43_22135	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_22145	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_22150	COG0307	riboflavin synthase, alpha
HPS43_22160	COG2271	Major facilitator Superfamily
HPS43_22170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPS43_22180	COG0789	Transcriptional regulator
HPS43_22205	COG4774	siderophore transport
HPS43_22215	COG0022	dehydrogenase e1 component
HPS43_22235	COG0165	Argininosuccinate lyase
HPS43_22240	COG0668	transmembrane transport
HPS43_22310	COG2165	general secretion pathway protein
HPS43_22340	COG0583	DNA-binding transcription factor activity
HPS43_22350	COG0747	negative chemotaxis
HPS43_22355	COG0601	transmembrane transport
HPS43_22365	COG4172	Belongs to the ABC transporter superfamily
HPS43_22370	COG4681	YaeQ
HPS43_22385	COG0477	Major facilitator Superfamily
HPS43_22390	COG3161	chorismate lyase activity
HPS43_22395	COG1187	pseudouridine synthase activity
HPS43_22400	COG0583	DNA-binding transcription factor activity
HPS43_22425	COG1999	signal sequence binding
HPS43_22435	COG0339	signal peptide processing
HPS43_22440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPS43_22445	COG4566	intracellular signal transduction
HPS43_22455	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPS43_22460	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPS43_22465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPS43_22475	COG0583	DNA-binding transcription factor activity
HPS43_22495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS43_22495	COG4797	methyltransferase
HPS43_22500	COG1191	sigma factor activity
HPS43_22520	COG1360	Flagellar Motor Protein
HPS43_22525	COG0745	RESPONSE REGULATOR receiver
HPS43_22535	COG0835	chemotaxis
HPS43_22540	COG0840	transmembrane signaling receptor activity
HPS43_22545	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPS43_22550	COG2201	protein-glutamate methylesterase activity
HPS43_22555	COG0745	RESPONSE REGULATOR receiver
HPS43_22560	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPS43_22565	COG0840	transmembrane signaling receptor activity
HPS43_22590	COG2747	anti-sigma28 factor FlgM
HPS43_22600	COG1815	bacterial-type flagellum-dependent cell motility
HPS43_22605	COG1558	bacterial-type flagellum-dependent cell motility
HPS43_22620	COG4787	bacterial-type flagellum-dependent cell motility
HPS43_22655	COG0840	transmembrane signaling receptor activity
HPS43_22670	COG0840	transmembrane signaling receptor activity
HPS43_22675	COG0840	transmembrane signaling receptor activity
HPS43_22710	COG1580	Controls the rotational direction of flagella during chemotaxis
HPS43_22735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPS43_22740	COG1766	The M ring may be actively involved in energy transduction
HPS43_22745	COG1677	Flagellar hook-basal body complex protein FliE
HPS43_22755	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPS43_22775	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPS43_22780	COG1334	flagellar protein FlaG
HPS43_22785	COG1414	Transcriptional regulator
HPS43_22795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_22800	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_22810	COG0285	dihydrofolate synthase activity
HPS43_22830	COG1451	nucleotide metabolic process
HPS43_22835	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPS43_22845	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPS43_22850	COG0024	Methionine aminopeptidase
HPS43_22855	COG0052	Belongs to the universal ribosomal protein uS2 family
HPS43_22860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPS43_22865	COG0528	UMP kinase activity
HPS43_22870	COG0233	cytoplasmic translational termination
HPS43_22875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPS43_22885	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPS43_22890	COG0750	zinc metalloprotease
HPS43_22895	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPS43_22900	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPS43_22905	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPS43_22910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPS43_22925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPS43_22930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPS43_22950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPS43_22950	COG2169	Transcriptional regulator
HPS43_22955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPS43_22955	COG0519	Catalyzes the synthesis of GMP from XMP
HPS43_22975	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPS43_22980	COG2867	negative regulation of translational initiation
HPS43_22985	COG2914	Belongs to the UPF0125 (RnfH) family
HPS43_22995	COG1024	Enoyl-CoA hydratase
HPS43_22995	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_23020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPS43_23025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPS43_23030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPS43_23035	COG0084	hydrolase, TatD family'
HPS43_23050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_23060	COG1126	abc transporter atp-binding protein
HPS43_23065	COG0010	Belongs to the arginase family
HPS43_23075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPS43_23085	COG0095	Lipoate-protein ligase
HPS43_23100	COG0625	glutathione transferase activity
HPS43_23110	COG1522	sequence-specific DNA binding
HPS43_23115	COG0386	Belongs to the glutathione peroxidase family
HPS43_23120	COG2814	Major facilitator Superfamily
HPS43_23140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPS43_23150	COG0840	transmembrane signaling receptor activity
HPS43_23165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_23200	COG1902	pentaerythritol trinitrate reductase activity
HPS43_23230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPS43_23245	COG0842	Transport permease protein
HPS43_23250	COG1131	(ABC) transporter
HPS43_23265	COG2130	NADP-dependent
HPS43_23290	COG3842	ATPase activity
HPS43_23295	COG3842	ATPase activity
HPS43_23305	COG0395	ABC-type sugar transport system, permease component
HPS43_23345	COG0346	lactoylglutathione lyase activity
HPS43_23350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_23370	COG3634	alkyl hydroperoxide reductase activity
HPS43_23375	COG1959	2 iron, 2 sulfur cluster binding
HPS43_23380	COG1960	acyl-CoA dehydrogenase activity
HPS43_23415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_23420	COG0420	3'-5' exonuclease activity
HPS43_23455	COG1006	Multisubunit Na H antiporter MnhC subunit
HPS43_23460	COG0651	ATP synthesis coupled electron transport
HPS43_23465	COG1863	multisubunit Na H antiporter MnhE subunit
HPS43_23470	COG2212	antiporter activity
HPS43_23475	COG1320	monovalent cation:proton antiporter activity
HPS43_23495	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPS43_23500	COG0488	(ABC) transporter
HPS43_23535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_23540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS43_23550	COG2252	PERMEase
HPS43_23555	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPS43_23560	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPS43_23570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPS43_23595	COG0583	DNA-binding transcription factor activity
HPS43_23600	COG2814	Major facilitator Superfamily
HPS43_23605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPS43_23610	COG0789	Transcriptional regulator
HPS43_23625	COG0678	peroxiredoxin activity
HPS43_23625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPS43_23635	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPS43_23640	COG0584	glycerophosphoryl diester phosphodiesterase
HPS43_23650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS43_23660	COG4181	ATPase activity
HPS43_23670	COG1178	ABC-type Fe3 transport system permease component
HPS43_23675	COG3842	ATPase activity
HPS43_23680	COG0583	DNA-binding transcription factor activity
HPS43_23685	COG0560	Phosphoserine phosphatase
HPS43_23700	COG0583	DNA-binding transcription factor activity
HPS43_23715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS43_23730	COG0583	DNA-binding transcription factor activity
HPS43_23735	COG4336	lyase activity
HPS43_23765	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_23785	COG2816	NAD+ diphosphatase activity
HPS43_23825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_23830	COG0765	amino acid transport
HPS43_23835	COG1126	abc transporter atp-binding protein
HPS43_23840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPS43_23845	COG1758	RNA polymerase activity
HPS43_23850	COG0194	GDP metabolic process
HPS43_23855	COG3258	Cytochrome c
HPS43_23860	COG2863	cytochrome
HPS43_23865	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_23875	COG2831	hemolysin activation secretion protein
HPS43_23880	COG3210	domain, Protein
HPS43_23890	COG0791	NLP P60 protein
HPS43_23905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPS43_23910	COG0833	amino acid
HPS43_23915	COG1561	YicC-like family, N-terminal region
HPS43_23920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPS43_23930	COG1960	acyl-CoA dehydrogenase activity
HPS43_23945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPS43_23950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPS43_23955	COG0174	glutamine synthetase
HPS43_23965	COG2204	response regulator
HPS43_23970	COG0583	DNA-binding transcription factor activity
HPS43_23975	COG1741	Belongs to the pirin family
HPS43_23980	COG1741	Belongs to the pirin family
HPS43_23985	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_23990	COG3842	ATPase activity
HPS43_23995	COG4149	molybdate abc transporter
HPS43_24000	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS43_24010	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_24025	COG0583	DNA-binding transcription factor activity
HPS43_24035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPS43_24045	COG0783	Belongs to the Dps family
HPS43_24055	COG0457	Tetratricopeptide repeat
HPS43_24060	COG0438	transferase activity, transferring glycosyl groups
HPS43_24085	COG1560	Kdo2-lipid A biosynthetic process
HPS43_24085	COG4783	chaperone-mediated protein folding
HPS43_24090	COG3866	Pectate lyase
HPS43_24105	COG0745	RESPONSE REGULATOR receiver
HPS43_24110	COG2205	protein histidine kinase activity
HPS43_24125	COG3842	ATPase activity
HPS43_24130	COG0395	ABC-type sugar transport system, permease component
HPS43_24135	COG1175	transmembrane transport
HPS43_24140	COG1653	transport
HPS43_24150	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPS43_24165	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_24190	COG1794	racemase activity, acting on amino acids and derivatives
HPS43_24195	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS43_24205	COG0583	DNA-binding transcription factor activity
HPS43_24210	COG0625	glutathione transferase activity
HPS43_24215	COG2133	pyrroloquinoline quinone binding
HPS43_24225	COG0697	spore germination
HPS43_24230	COG2363	Small membrane protein
HPS43_24250	COG0010	Belongs to the arginase family
HPS43_24260	COG1464	Belongs to the NlpA lipoprotein family
HPS43_24270	COG2814	Major facilitator Superfamily
HPS43_24280	COG1408	metallophosphoesterase
HPS43_24290	COG0688	phosphatidylethanolamine metabolic process
HPS43_24295	COG0488	(ABC) transporter
HPS43_24320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_24325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPS43_24330	COG5001	Diguanylate cyclase
HPS43_24330	COG3300	MHYT domain
HPS43_24345	COG2814	Major facilitator Superfamily
HPS43_24360	COG2814	Major facilitator Superfamily
HPS43_24365	COG4771	TonB-dependent receptor
HPS43_24385	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPS43_24390	COG2204	response regulator
HPS43_24425	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_24445	COG0693	protein deglycase activity
HPS43_24465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS43_24475	COG1289	transmembrane transporter activity
HPS43_24480	COG3300	MHYT domain
HPS43_24480	COG5001	Diguanylate cyclase
HPS43_24530	COG1253	flavin adenine dinucleotide binding
HPS43_24545	COG2205	protein histidine kinase activity
HPS43_24705	COG3706	GGDEF domain
HPS43_24710	COG0789	Transcriptional regulator
HPS43_24720	COG3706	GGDEF domain
HPS43_24750	COG1116	anion transmembrane transporter activity
HPS43_24755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_24760	COG4521	taurine ABC transporter
HPS43_24785	COG0793	Belongs to the peptidase S41A family
HPS43_24805	COG0628	permease
HPS43_24815	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPS43_24840	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS43_24845	COG4608	Belongs to the ABC transporter superfamily
HPS43_24850	COG0444	Belongs to the ABC transporter superfamily
HPS43_24860	COG0601	transmembrane transport
HPS43_24865	COG0747	negative chemotaxis
HPS43_24875	COG0251	oxidation-reduction process
HPS43_24895	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS43_24910	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HPS43_24925	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPS43_24935	COG3971	2-oxopent-4-enoate hydratase activity
HPS43_24965	COG0625	glutathione transferase activity
HPS43_24980	COG0477	Major facilitator Superfamily
HPS43_24990	COG0579	oxidoreductase
HPS43_25005	COG0625	glutathione transferase activity
HPS43_25030	COG0798	PFAM Bile acid sodium symporter
HPS43_25040	COG0640	Transcriptional regulator
HPS43_25050	COG0668	transmembrane transport
HPS43_25070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_25075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_25095	COG0583	DNA-binding transcription factor activity
HPS43_25100	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPS43_25120	COG1126	abc transporter atp-binding protein
HPS43_25125	COG0765	amino acid transport
HPS43_25130	COG4597	amino acid ABC transporter
HPS43_25135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_25140	COG0626	cystathionine gamma-synthase activity
HPS43_25145	COG0583	DNA-binding transcription factor activity
HPS43_25165	COG0444	Belongs to the ABC transporter superfamily
HPS43_25175	COG0601	transmembrane transport
HPS43_25180	COG0747	negative chemotaxis
HPS43_25190	COG0583	DNA-binding transcription factor activity
HPS43_25195	COG1335	isochorismatase
HPS43_25200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS43_25210	COG2358	TRAP transporter, solute receptor (TAXI family
HPS43_25215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_25220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_25230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS43_25235	COG0519	Catalyzes the synthesis of GMP from XMP
HPS43_25235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPS43_25245	COG1276	copper resistance
HPS43_25265	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_25270	COG3386	PFAM SMP-30 Gluconolaconase
HPS43_25275	COG2721	sulfolactate sulfo-lyase activity
HPS43_25295	COG0745	RESPONSE REGULATOR receiver
HPS43_25305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_25310	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HPS43_25315	COG3842	ATPase activity
HPS43_25320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPS43_25335	COG0586	Pfam SNARE associated Golgi protein
HPS43_25340	COG0390	transport system, permease component
HPS43_25350	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HPS43_25395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_25400	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_25405	COG1120	ATPase activity
HPS43_25410	COG1126	abc transporter atp-binding protein
HPS43_25415	COG0765	amino acid transport
HPS43_25425	COG2070	2-Nitropropane dioxygenase
HPS43_25430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_25440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS43_25465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPS43_25470	COG0583	DNA-binding transcription factor activity
HPS43_25480	COG1846	Transcriptional regulator
HPS43_25490	COG4191	Histidine kinase
HPS43_25495	COG4566	intracellular signal transduction
HPS43_25530	COG0583	DNA-binding transcription factor activity
HPS43_25560	COG0765	amino acid transport
HPS43_25565	COG0436	Aminotransferase
HPS43_25590	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HPS43_25615	COG0251	oxidation-reduction process
HPS43_25655	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_25665	COG1802	Transcriptional regulator
HPS43_25670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_25685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS43_25710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_25715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS43_25720	COG1116	anion transmembrane transporter activity
HPS43_25755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_25760	COG4597	amino acid ABC transporter
HPS43_25765	COG3154	lipid carrier protein
HPS43_25770	COG0826	peptidase U32
HPS43_25775	COG0826	peptidase U32
HPS43_25780	COG2197	response regulator
HPS43_25785	COG3850	Histidine kinase
HPS43_25790	COG1763	Mo-molybdopterin cofactor biosynthetic process
HPS43_25795	COG0288	reversible hydration of carbon dioxide
HPS43_25800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPS43_25805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS43_25810	COG2181	nitrate reductase activity
HPS43_25815	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPS43_25820	COG1140	nitrate reductase beta subunit
HPS43_25830	COG2223	nitrite transmembrane transporter activity
HPS43_25855	COG0583	DNA-binding transcription factor activity
HPS43_25875	COG0583	DNA-binding transcription factor activity
HPS43_25885	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_25915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_25935	COG2070	2-Nitropropane dioxygenase
HPS43_25950	COG5002	protein histidine kinase activity
HPS43_25955	COG0745	RESPONSE REGULATOR receiver
HPS43_25960	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HPS43_25965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPS43_25975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS43_25980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS43_25995	COG0783	Belongs to the Dps family
HPS43_26025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_26030	COG0697	spore germination
HPS43_26035	COG2879	small protein
HPS43_26040	COG1966	Carbon starvation protein
HPS43_26065	COG0583	DNA-binding transcription factor activity
HPS43_26070	COG4521	taurine ABC transporter
HPS43_26075	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HPS43_26080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_26095	COG2274	protein secretion by the type I secretion system
HPS43_26100	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPS43_26115	COG3712	iron ion homeostasis
HPS43_26120	COG1595	DNA-templated transcription, initiation
HPS43_26125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_26135	COG0235	Class ii aldolase
HPS43_26140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_26150	COG0523	cobalamin synthesis protein
HPS43_26155	COG1228	amidohydrolase
HPS43_26160	COG4172	Belongs to the ABC transporter superfamily
HPS43_26165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_26170	COG0601	transmembrane transport
HPS43_26175	COG4166	transmembrane transport
HPS43_26190	COG1414	Transcriptional regulator
HPS43_26195	COG0513	Belongs to the DEAD box helicase family
HPS43_26200	COG0602	queuosine metabolic process
HPS43_26205	COG0720	synthase
HPS43_26215	COG1289	transmembrane transporter activity
HPS43_26225	COG1566	PFAM secretion protein HlyD family protein
HPS43_26240	COG0028	Belongs to the TPP enzyme family
HPS43_26250	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_26260	COG0400	carboxylic ester hydrolase activity
HPS43_26265	COG0833	amino acid
HPS43_26285	COG0587	DNA-directed DNA polymerase activity
HPS43_26305	COG0667	Aldo Keto reductase
HPS43_26315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPS43_26335	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_26380	COG3038	cytochrome b561
HPS43_26405	COG0840	transmembrane signaling receptor activity
HPS43_26485	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HPS43_26505	COG4774	siderophore transport
HPS43_26510	COG2345	Transcriptional regulator
HPS43_26520	COG1414	Transcriptional regulator
HPS43_26535	COG0667	Aldo Keto reductase
HPS43_26545	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_26550	COG1309	transcriptional regulator
HPS43_26570	COG1683	Conserved Protein
HPS43_26580	COG2207	Transcriptional regulator
HPS43_26600	COG3047	cAMP biosynthetic process
HPS43_26600	COG2885	chlorophyll binding
HPS43_26615	COG3795	YCII-related domain
HPS43_26620	COG3795	YCII-related domain
HPS43_26630	COG4941	Belongs to the sigma-70 factor family
HPS43_26640	COG0697	spore germination
HPS43_26650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPS43_26660	COG0583	DNA-binding transcription factor activity
HPS43_26690	COG1846	Transcriptional regulator
HPS43_26695	COG3541	Predicted nucleotidyltransferase
HPS43_26715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_26765	COG1360	Flagellar Motor Protein
HPS43_26775	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HPS43_26825	COG3501	Rhs element vgr protein
HPS43_26885	COG3501	Rhs element vgr protein
HPS43_26980	COG0625	glutathione transferase activity
HPS43_26985	COG2032	superoxide dismutase activity
HPS43_26990	COG2733	membrane
HPS43_27000	COG0148	phosphopyruvate hydratase activity
HPS43_27025	COG0583	DNA-binding transcription factor activity
HPS43_27030	COG1024	Enoyl-CoA hydratase
HPS43_27030	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_27035	COG0183	Belongs to the thiolase family
HPS43_27040	COG1960	acyl-CoA dehydrogenase activity
HPS43_27045	COG1960	acyl-CoA dehydrogenase activity
HPS43_27050	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_27060	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HPS43_27075	COG0583	DNA-binding transcription factor activity
HPS43_27085	COG1846	Transcriptional regulator
HPS43_27090	COG0477	Major facilitator Superfamily
HPS43_27095	COG2010	Cytochrome c
HPS43_27095	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPS43_27100	COG2080	2 iron, 2 sulfur cluster binding
HPS43_27110	COG0596	Alpha beta hydrolase
HPS43_27115	COG2309	aminopeptidase activity
HPS43_27120	COG1335	isochorismatase
HPS43_27125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPS43_27125	COG2010	Cytochrome c
HPS43_27135	COG1522	sequence-specific DNA binding
HPS43_27140	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_27145	COG3842	ATPase activity
HPS43_27150	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS43_27155	COG4149	molybdate abc transporter
HPS43_27160	COG4251	negative regulation of phosphorylation
HPS43_27160	COG3706	GGDEF domain
HPS43_27160	COG2203	Gaf domain
HPS43_27160	COG5001	Diguanylate cyclase
HPS43_27165	COG2201	protein-glutamate methylesterase activity
HPS43_27190	COG0840	transmembrane signaling receptor activity
HPS43_27210	COG0583	DNA-binding transcription factor activity
HPS43_27240	COG0456	acetyltransferase
HPS43_27255	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_27325	COG0165	Argininosuccinate lyase
HPS43_27340	COG0583	DNA-binding transcription factor activity
HPS43_27355	COG2205	protein histidine kinase activity
HPS43_27365	COG2267	carboxylic ester hydrolase activity
HPS43_27375	COG4221	oxidoreductase activity
HPS43_27380	COG2207	Transcriptional regulator
HPS43_27410	COG0640	Transcriptional regulator
HPS43_27415	COG0640	Transcriptional regulator
HPS43_27425	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPS43_27430	COG0583	DNA-binding transcription factor activity
HPS43_27435	COG0431	NADPH-dependent FMN reductase
HPS43_27490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPS43_27490	COG0519	Catalyzes the synthesis of GMP from XMP
HPS43_27515	COG0583	DNA-binding transcription factor activity
HPS43_27525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS43_27550	COG0583	DNA-binding transcription factor activity
HPS43_27555	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_27585	COG2072	flavoprotein involved in K transport
HPS43_27590	COG0601	transmembrane transport
HPS43_27595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_27605	COG4608	Belongs to the ABC transporter superfamily
HPS43_27610	COG0747	negative chemotaxis
HPS43_27655	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS43_27680	COG0583	DNA-binding transcription factor activity
HPS43_27735	COG5001	Diguanylate cyclase
HPS43_27740	COG4774	siderophore transport
HPS43_27755	COG0583	DNA-binding transcription factor activity
HPS43_27805	COG1953	Uracil, thiamine, allantoin
HPS43_27840	COG0583	DNA-binding transcription factor activity
HPS43_27845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_27845	COG2198	Histidine kinase
HPS43_27845	COG2205	protein histidine kinase activity
HPS43_27845	COG0784	Response regulator, receiver
HPS43_27850	COG0745	RESPONSE REGULATOR receiver
HPS43_27850	COG2205	protein histidine kinase activity
HPS43_27850	COG3292	Two component regulator propeller
HPS43_27880	COG0583	DNA-binding transcription factor activity
HPS43_27885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_27895	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_27905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPS43_27920	COG0583	DNA-binding transcription factor activity
HPS43_27945	COG0745	RESPONSE REGULATOR receiver
HPS43_27965	COG1595	DNA-templated transcription, initiation
HPS43_27970	COG3712	iron ion homeostasis
HPS43_27975	COG4774	siderophore transport
HPS43_27980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPS43_27980	COG0047	phosphoribosylformylglycinamidine synthase activity
HPS43_27995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_28035	COG0613	PHP domain protein
HPS43_28050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS43_28060	COG0583	DNA-binding transcription factor activity
HPS43_28070	COG0583	DNA-binding transcription factor activity
HPS43_28075	COG0477	Major facilitator Superfamily
HPS43_28080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS43_28090	COG0159	tryptophan synthase activity
HPS43_28115	COG0277	FAD linked oxidase domain protein
HPS43_28120	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_28130	COG3119	arylsulfatase activity
HPS43_28165	COG2149	membrane
HPS43_28175	COG3093	addiction module antidote protein HigA
HPS43_28200	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPS43_28210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPS43_28215	COG0459	protein refolding
HPS43_28250	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPS43_28255	COG0714	Associated with various cellular activities
HPS43_28275	COG2304	oxidoreductase activity
HPS43_28290	COG3119	arylsulfatase activity
HPS43_28300	COG1280	lysine exporter protein (LysE YggA)
HPS43_28330	COG0633	Ferredoxin
HPS43_28335	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_28340	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_28345	COG4133	protoheme IX ABC transporter activity
HPS43_28350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPS43_28390	COG4604	ABC transporter, ATP-binding protein
HPS43_28395	COG4605	iron ion homeostasis
HPS43_28400	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_28405	COG4607	ABC-type enterochelin transport system periplasmic component
HPS43_28410	COG4771	TonB-dependent receptor
HPS43_28415	COG0745	RESPONSE REGULATOR receiver
HPS43_28425	COG0084	hydrolase, TatD family'
HPS43_28430	COG1136	(ABC) transporter
HPS43_28450	COG2271	Major facilitator Superfamily
HPS43_28460	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_28465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPS43_28480	COG3135	benzoate transporter
HPS43_28485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPS43_28490	COG1309	transcriptional regulator
HPS43_28495	COG0183	Belongs to the thiolase family
HPS43_28500	COG1022	Amp-dependent synthetase and ligase
HPS43_28530	COG1024	Enoyl-CoA hydratase
HPS43_28540	COG1803	Methylglyoxal synthase
HPS43_28545	COG2975	iron-sulfur cluster assembly
HPS43_28550	COG0633	Ferredoxin
HPS43_28555	COG0443	Heat shock 70 kDa protein
HPS43_28560	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPS43_28565	COG0316	Belongs to the HesB IscA family
HPS43_28570	COG0822	iron-sulfur transferase activity
HPS43_28575	COG1104	cysteine desulfurase activity
HPS43_28585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPS43_28590	COG0556	nucleotide-excision repair
HPS43_28600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPS43_28605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPS43_28610	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPS43_28615	COG0740	serine-type endopeptidase activity
HPS43_28620	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPS43_28625	COG0501	Belongs to the peptidase M48B family
HPS43_28635	COG1278	Cold shock
HPS43_28645	COG1278	Cold shock
HPS43_28670	COG0251	oxidation-reduction process
HPS43_28680	COG0583	DNA-binding transcription factor activity
HPS43_28715	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPS43_28740	COG0277	FAD linked oxidase domain protein
HPS43_28755	COG2814	Major facilitator Superfamily
HPS43_28905	COG0740	serine-type endopeptidase activity
HPS43_29070	COG1475	DNA binding
HPS43_29135	COG2171	N-acyltransferase activity
HPS43_29145	COG2890	protein-(glutamine-N5) methyltransferase activity
HPS43_29150	COG0488	(ABC) transporter
HPS43_29165	COG4771	TonB-dependent receptor
HPS43_29170	COG4771	TonB-dependent receptor
HPS43_29175	COG4771	TonB-dependent receptor
HPS43_29185	COG1858	cytochrome C peroxidase
HPS43_29195	COG0210	DNA helicase
HPS43_29210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPS43_29210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPS43_29215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPS43_29220	COG0196	riboflavin kinase activity
HPS43_29225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPS43_29230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPS43_29235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPS43_29285	COG1902	pentaerythritol trinitrate reductase activity
HPS43_29290	COG1126	abc transporter atp-binding protein
HPS43_29295	COG0765	amino acid transport
HPS43_29300	COG0765	amino acid transport
HPS43_29305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_29315	COG2423	ornithine cyclodeaminase activity
HPS43_29320	COG1764	response to oxidative stress
HPS43_29330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS43_29335	COG0625	glutathione transferase activity
HPS43_29345	COG4178	(ABC) transporter
HPS43_29355	COG4771	TonB-dependent receptor
HPS43_29370	COG2271	Major facilitator Superfamily
HPS43_29400	COG0506	proline dehydrogenase activity
HPS43_29400	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPS43_29400	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPS43_29410	COG3008	intermembrane lipid transfer
HPS43_29415	COG2995	paraquat-inducible protein a
HPS43_29425	COG4953	penicillin-binding protein 1C
HPS43_29430	COG2373	Large extracellular alpha-helical protein
HPS43_29435	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPS43_29440	COG1278	Cold shock
HPS43_29450	COG0183	Belongs to the thiolase family
HPS43_29455	COG0038	chloride channel
HPS43_29465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPS43_29475	COG1570	exodeoxyribonuclease VII activity
HPS43_29480	COG0811	peptide transport
HPS43_29490	COG1663	tetraacyldisaccharide 4'-kinase activity
HPS43_29500	COG2835	tetraacyldisaccharide 4'-kinase activity
HPS43_29505	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPS43_29510	COG0563	adenylate kinase activity
HPS43_29520	COG0728	peptidoglycan biosynthetic process
HPS43_29530	COG0268	Binds directly to 16S ribosomal RNA
HPS43_29535	COG0583	DNA-binding transcription factor activity
HPS43_29550	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_29555	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPS43_29560	COG2186	Transcriptional regulator
HPS43_29570	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_29580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS43_29610	COG3384	dioxygenase
HPS43_29615	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_29630	COG3971	2-oxopent-4-enoate hydratase activity
HPS43_29640	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_29645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPS43_29650	COG1562	ergosterol biosynthetic process
HPS43_29655	COG1562	ergosterol biosynthetic process
HPS43_29665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPS43_29690	COG1477	protein flavinylation
HPS43_29695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPS43_29705	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS43_29720	COG5564	TIM-barrel signal transduction protein
HPS43_29725	COG5441	Belongs to the UPF0261 family
HPS43_29750	COG0542	response to heat
HPS43_29760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPS43_29770	COG0477	Major facilitator Superfamily
HPS43_29790	COG0494	nUDIX hydrolase
HPS43_29795	COG0583	DNA-binding transcription factor activity
HPS43_29800	COG0443	Heat shock 70 kDa protein
HPS43_29835	COG2814	Major facilitator Superfamily
HPS43_29845	COG3530	Putative quorum-sensing-regulated virulence factor
HPS43_29860	COG0625	glutathione transferase activity
HPS43_29885	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_29895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS43_29955	COG1522	sequence-specific DNA binding
HPS43_29990	COG0519	Catalyzes the synthesis of GMP from XMP
HPS43_30010	COG1595	DNA-templated transcription, initiation
HPS43_30030	COG0519	Catalyzes the synthesis of GMP from XMP
HPS43_30035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPS43_30040	COG2951	lytic endotransglycosylase activity
HPS43_30050	COG0583	DNA-binding transcription factor activity
HPS43_30060	COG2272	Belongs to the type-B carboxylesterase lipase family
HPS43_30065	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_30080	COG1473	amidohydrolase
HPS43_30090	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HPS43_30105	COG3618	amidohydrolase
HPS43_30110	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_30145	COG2011	ABC-type metal ion transport system permease component
HPS43_30150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPS43_30155	COG1464	Belongs to the NlpA lipoprotein family
HPS43_30165	COG2814	Major facilitator Superfamily
HPS43_30175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPS43_30180	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_30210	COG0543	2 iron, 2 sulfur cluster binding
HPS43_30210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPS43_30220	COG2837	iron assimilation
HPS43_30230	COG0583	DNA-binding transcription factor activity
HPS43_30235	COG2814	Major facilitator Superfamily
HPS43_30240	COG2169	Transcriptional regulator
HPS43_30270	COG1272	protein, Hemolysin III
HPS43_30280	COG1278	Cold shock
HPS43_30310	COG4638	Rieske (2fe-2S)
HPS43_30325	COG0604	alcohol dehydrogenase
HPS43_30325	COG3321	synthase
HPS43_30335	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_30340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_30365	COG0183	Belongs to the thiolase family
HPS43_30380	COG0842	Transport permease protein
HPS43_30385	COG1131	(ABC) transporter
HPS43_30405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS43_30435	COG0811	peptide transport