locus-tag class description HPS44_00035 ENOG4108K3A Glutathione S-transferase HPS44_00045 ENOG41082F9 transcriptional regulator HPS44_00050 ENOG410756H nucleotidyltransferase HPS44_00110 ENOG4105ER2 Ompa motb domain protein HPS44_00150 ENOG4105CS6 Rhs element vgr protein HPS44_00155 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPS44_00210 ENOG4105CS6 Rhs element vgr protein HPS44_00290 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPS44_00300 ENOG4108TGY Glutathione S-transferase HPS44_00305 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPS44_00310 ENOG4106BRA Membrane HPS44_00320 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HPS44_00345 ENOG4105CBN LysR family transcriptional regulator HPS44_00350 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_00355 ENOG4105CHU acetyl-coa acetyltransferase HPS44_00360 ENOG4105CC9 acyl-Coa dehydrogenase HPS44_00365 ENOG4105C1G acyl-Coa dehydrogenase HPS44_00370 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_00375 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HPS44_00395 ENOG4105F04 LysR family Transcriptional regulator HPS44_00405 ENOG4108VHT MarR family transcriptional regulator HPS44_00410 ENOG41079KZ Major Facilitator Superfamily HPS44_00415 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HPS44_00420 ENOG4108XHQ (2Fe-2S)-binding domain protein HPS44_00440 ENOG4108UAU isochorismatase HPS44_00445 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HPS44_00455 ENOG4105F7P transcriptional regulator AsnC family HPS44_00465 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_00475 ENOG4105E0C molybdate abc transporter HPS44_00485 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HPS44_00490 ENOG4105CBS Chea signal transduction histidine kinase HPS44_00500 ENOG4108KTQ Methyltransferase HPS44_00510 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_00515 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPS44_00530 ENOG4105CC0 LysR family Transcriptional regulator HPS44_00550 ENOG4105F2V VRR-NUC domain-containing protein HPS44_00560 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HPS44_00595 ENOG4105C57 major facilitator superfamily HPS44_00630 ENOG4106IQC argininosuccinate lyase HPS44_00645 ENOG4105EJC lysr family transcriptional regulator HPS44_00650 ENOG4108Z6Z Transcriptional regulator HPS44_00660 ENOG4105JJR Histidine kinase HPS44_00680 ENOG4105R1U AraC Family Transcriptional Regulator HPS44_00685 ENOG4105D74 hydrolase HPS44_00695 ENOG4105EMU Dehydrogenase HPS44_00700 ENOG4105CF7 AraC family transcriptional regulator HPS44_00740 ENOG4105MHT Transcriptional regulator, ARSR family HPS44_00745 ENOG4105WAB arsR family transcriptional regulator HPS44_00755 ENOG4105DAE Methylenetetrahydrofolate reductase HPS44_00760 ENOG4105DZ2 Transcriptional regulator HPS44_00765 ENOG4108UZX fmn reductase HPS44_00810 ENOG4105CVR type I restriction-modification system HPS44_00815 ENOG4105C0D helicase HPS44_00820 ENOG4108I5C dEAD DEAH box helicase HPS44_00835 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPS44_00840 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HPS44_00865 ENOG4107RSM transcriptional regulator HPS44_00875 ENOG4105C5I Dehydrogenase HPS44_00895 ENOG4106NZI LysR family Transcriptional regulator HPS44_00905 ENOG4105DV0 amidase (EC 3.5.1.4 HPS44_00945 ENOG4105E1J oxidoreductase HPS44_00950 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPS44_00955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_00960 ENOG4105C3U ABC transporter HPS44_00965 ENOG4108JQ7 (ABC) transporter HPS44_00970 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_01000 ENOG4105E0K tonB-dependent siderophore receptor HPS44_01005 ENOG4105E7U AraC family transcriptional regulator HPS44_01020 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HPS44_01040 ENOG4105CI0 Citrate lyase HPS44_01045 ENOG4105DND Transcriptional regulator HPS44_01065 ENOG4105CNM Receptor HPS44_01105 ENOG41060WC Enoyl-CoA hydratase HPS44_01110 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_01115 ENOG4105D2B acyl-CoA dehydrogenase HPS44_01125 ENOG4107F9Y LysR family transcriptional regulator HPS44_01130 ENOG4105GAK amidohydrolase 2 HPS44_01145 ENOG4107RT4 flavin reductase domain protein HPS44_01170 ENOG4108K0B C-di-gmp phosphodiesterase HPS44_01175 ENOG4105E0K tonB-dependent siderophore receptor HPS44_01180 ENOG4105E0K tonB-dependent siderophore receptor HPS44_01195 ENOG4105CBN LysR family transcriptional regulator HPS44_01220 ENOG4105ZRN HPS44_01235 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HPS44_01245 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HPS44_01270 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HPS44_01280 ENOG4105BZU Histidine kinase HPS44_01315 ENOG4107YNJ LysR family Transcriptional regulator HPS44_01320 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_01330 ENOG4105CHR reductase HPS44_01340 ENOG41082CG Protein CrcB homolog HPS44_01355 ENOG4107YNJ LysR family Transcriptional regulator HPS44_01380 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_01395 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_01400 ENOG4108ETH Formylglycinamide ribotide synthetase HPS44_01410 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_01415 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPS44_01420 ENOG4108RRZ Transcription elongation factor GreB HPS44_01425 ENOG4105DB7 PHP domain protein HPS44_01440 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HPS44_01450 ENOG4105DND Transcriptional regulator HPS44_01460 ENOG4105DUM transcriptional regulator, lysR family HPS44_01465 ENOG4105CSH Transporter HPS44_01470 ENOG4107S4Y M20 DapE family protein YgeY HPS44_01475 ENOG4108EC8 DNA internalization-related competence protein ComEC HPS44_01480 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HPS44_01490 ENOG4108MGI Transcriptional regulator HPS44_01505 ENOG4105CXG d-lactate dehydrogenase HPS44_01555 ENOG4105VG5 Membrane HPS44_01560 ENOG4105JP4 Inner membrane protein yidG HPS44_01580 ENOG4108X0B nad(p)h dehydrogenase (quinone) HPS44_01590 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HPS44_01595 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HPS44_01640 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPS44_01675 ENOG4105ENH Sulfatase HPS44_01685 ENOG4105N14 lysine exporter protein LysE YggA HPS44_01715 ENOG4108ZIT Ferredoxin, 2FE-2S HPS44_01725 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HPS44_01745 ENOG4105EUZ Beta-lactamase domain protein HPS44_01755 ENOG4105E0K tonB-dependent siderophore receptor HPS44_01760 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HPS44_01765 ENOG4108IPW abc transporter atp-binding protein HPS44_01770 ENOG4105CM4 permease protein HPS44_01775 ENOG4105DHS permease protein HPS44_01785 ENOG4105D05 Receptor HPS44_01790 ENOG4105E3W Two component transcriptional regulator (Winged helix family HPS44_01795 ENOG410804D Sensor Signal Transduction Histidine Kinase HPS44_01800 ENOG4105F8V Hydrolase, tatD family HPS44_01805 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HPS44_01820 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HPS44_01825 ENOG4105CSP Major Facilitator Superfamily HPS44_01835 ENOG410904N short-chain dehydrogenase reductase HPS44_01840 ENOG4105CRK lysyL-tRNA synthetase HPS44_01855 ENOG4105DKK Benzoate HPS44_01860 ENOG4105DFA alanine racemase domain protein HPS44_01870 ENOG4105CHU acetyl-coa acetyltransferase HPS44_01875 ENOG4108IQE Amp-dependent synthetase and ligase HPS44_01880 ENOG4108IV0 ABC, transporter HPS44_01900 ENOG4105C0Z ABC transporter HPS44_01905 ENOG4105CGU Enoyl-CoA hydratase HPS44_01915 ENOG4108Z5K methylglyoxal synthase HPS44_01920 ENOG4105WVQ Fe-S assembly protein IscX HPS44_01925 ENOG4108ZIT Ferredoxin, 2FE-2S HPS44_01930 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HPS44_01935 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HPS44_01940 ENOG4108Z4V iron-sulfur cluster assembly HPS44_01945 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HPS44_01950 ENOG4105C3J Cysteine desulfurase HPS44_01965 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HPS44_01970 ENOG4105CGF Aromatic amino acid aminotransferase HPS44_01975 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HPS44_01980 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HPS44_01985 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HPS44_01990 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HPS44_01995 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HPS44_02000 ENOG4108K0D peptidase, M48 HPS44_02005 ENOG4108TEB UPF0114 protein HPS44_02010 ENOG4105VEQ Cold shock protein HPS44_02020 ENOG4105VEQ Cold shock protein HPS44_02045 ENOG4105KME endoribonuclease L-psp HPS44_02055 ENOG4105EJC lysr family transcriptional regulator HPS44_02070 ENOG4108IG5 Transcriptional regulator HPS44_02090 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HPS44_02125 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HPS44_02165 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HPS44_02175 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HPS44_02180 ENOG4105C5H ABC transporter HPS44_02195 ENOG4105PE1 Receptor HPS44_02200 ENOG4105PE1 Receptor HPS44_02205 ENOG4105PE1 Receptor HPS44_02225 ENOG4105C4R Atp-dependent dna helicase HPS44_02245 ENOG4108V3E phosphoribosylglycinamide formyltransferase HPS44_02250 ENOG4105DTN riboflavin biosynthesis protein ribF HPS44_02255 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HPS44_02260 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HPS44_02265 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HPS44_02285 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) HPS44_02320 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPS44_02350 ENOG4105CIF Ornithine Cyclodeaminase HPS44_02355 ENOG4108Z9K Osmotically inducible protein HPS44_02360 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HPS44_02370 ENOG4105CYM Glutathione S-transferase HPS44_02380 ENOG4105CQ0 ABC transporter HPS44_02390 ENOG4107ENK receptor HPS44_02405 ENOG4105DCM major facilitator superfamily HPS44_02410 ENOG4108IV0 ABC, transporter HPS44_02415 ENOG4105C0Z ABC transporter HPS44_02420 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_02425 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_02435 ENOG4105C26 Dehydrogenase HPS44_02445 ENOG4105DY2 Paraquat-inducible protein b HPS44_02450 ENOG4105F1S paraquat-inducible protein a HPS44_02460 ENOG4108JQB penicillin-binding protein 1C HPS44_02470 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HPS44_02475 ENOG4105VEQ Cold shock protein HPS44_02485 ENOG4105CHU acetyl-coa acetyltransferase HPS44_02490 ENOG4105CMQ Chloride channel HPS44_02495 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_02500 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPS44_02510 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HPS44_02525 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HPS44_02535 ENOG4105W49 UPF0434 protein HPS44_02540 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HPS44_02555 ENOG4105CJR Integral membrane protein (MviN HPS44_02565 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) HPS44_02570 ENOG4105RQF LysR family Transcriptional regulator HPS44_02580 ENOG4105CNV Aldolase HPS44_02590 ENOG4105DG4 malate L-lactate dehydrogenase HPS44_02595 ENOG4107YCY Transcriptional regulator HPS44_02615 ENOG4105C5I Dehydrogenase HPS44_02630 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HPS44_02645 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HPS44_02650 ENOG4105C26 Dehydrogenase HPS44_02675 ENOG4105CHR reductase HPS44_02680 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPS44_02700 ENOG4108ARY Protein CrcB homolog HPS44_02735 ENOG4105EQN UPF0261 protein HPS44_02760 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPS44_02770 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HPS44_02780 ENOG4105CSH Transporter HPS44_02800 ENOG4108YZ4 nudix hydrolase HPS44_02805 ENOG4105CR8 Transcriptional regulator HPS44_02810 ENOG4105R8A Heat shock protein HPS44_02825 ENOG4105CNM Receptor HPS44_02830 ENOG4105CNM Receptor HPS44_02835 ENOG4105WPR Transcriptional regulator, ARAC family HPS44_02855 ENOG4105VRT cytoplasmic protein HPS44_02870 ENOG4108TGY Glutathione S-transferase HPS44_02895 ENOG4105GAK amidohydrolase 2 HPS44_02910 ENOG4108JQ1 Dehydrogenase HPS44_02960 ENOG4108XM1 transcriptional regulator AsnC family HPS44_02985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_02995 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPS44_03015 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPS44_03020 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HPS44_03025 ENOG4105CVE Lytic murein transglycosylase HPS44_03035 ENOG4105DDW LysR family Transcriptional regulator HPS44_03045 ENOG4105EBR Carboxylesterase HPS44_03065 ENOG4105CH2 amidohydrolase HPS44_03075 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) HPS44_03090 ENOG4105GAK amidohydrolase 2 HPS44_03100 ENOG4105BZU Histidine kinase HPS44_03105 ENOG4105VEJ Heat shock protein HPS44_03110 ENOG4105CSR polyphosphate kinase 2 HPS44_03130 ENOG4108UMI ABC transporter, permease HPS44_03135 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPS44_03140 ENOG4105D01 (LipO)protein HPS44_03150 ENOG4105DNH Major Facilitator HPS44_03160 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HPS44_03165 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_03185 ENOG4105JAB phenazine biosynthesis protein, phzf family HPS44_03205 ENOG4105EZR dyp-type peroxidase family protein HPS44_03230 ENOG4105CBN LysR family transcriptional regulator HPS44_03235 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPS44_03270 ENOG4108UT2 hemolysin iii HPS44_03295 ENOG4105DVW rieske (2Fe-2S) HPS44_03310 ENOG4108JA1 polyketide synthase HPS44_03325 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_03330 ENOG4108ERU trap dicarboxylate transporter subunit DctP HPS44_03340 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_03345 ENOG4108ZXC Two component transcriptional regulator, luxr family HPS44_03355 ENOG4105CHU acetyl-coa acetyltransferase HPS44_03370 ENOG4105E3A (ABC) transporter HPS44_03375 ENOG4105DA5 (ABC) transporter HPS44_03380 ENOG4105BZU Histidine kinase HPS44_03385 ENOG4105WH1 Two component transcriptional regulator luxr family HPS44_03400 ENOG4105D7T ABC transporter HPS44_03405 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HPS44_03425 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HPS44_03450 ENOG4105SG9 biopolymer transport protein, ExbD HPS44_03455 ENOG4105E02 MotA TolQ exbB proton channel HPS44_03520 ENOG4108S8N class II Aldolase HPS44_03540 ENOG4107RSM transcriptional regulator HPS44_03560 ENOG4105CN8 Transcriptional regulator HPS44_03575 ENOG4105CHR reductase HPS44_03585 ENOG4105GAK amidohydrolase 2 HPS44_03610 ENOG4105CGU Enoyl-CoA hydratase HPS44_03670 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPS44_03675 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HPS44_03695 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPS44_03700 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HPS44_03705 ENOG41083Z3 extracellular ligand-binding receptor HPS44_03710 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_03720 ENOG4105C0Z ABC transporter HPS44_03725 ENOG4108IV0 ABC, transporter HPS44_03760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_03765 ENOG4105BZU Histidine kinase HPS44_03780 ENOG4105CC0 LysR family Transcriptional regulator HPS44_03790 ENOG4105BZU Histidine kinase HPS44_03805 ENOG41061WM D-Alanyl-D-Alanine HPS44_03815 ENOG4105EXC Acyl-transferase HPS44_03830 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) HPS44_03860 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_03875 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_03880 ENOG41069H7 transport system small permease component HPS44_03885 ENOG4105CH5 extracellular solute-binding protein, family 7 HPS44_03900 ENOG4105ETE Transcriptional regulator (LacI family HPS44_03905 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPS44_03910 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_03920 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate HPS44_03935 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HPS44_03940 ENOG4105CSW GntR family transcriptional regulator HPS44_03955 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HPS44_03960 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HPS44_03975 ENOG4105CF7 AraC family transcriptional regulator HPS44_03980 ENOG4107U9B transcriptional regulator HPS44_03995 ENOG4105JAB phenazine biosynthesis protein, phzf family HPS44_04075 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HPS44_04080 ENOG4108R85 Short chain dehydrogenase HPS44_04085 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HPS44_04095 ENOG4108JJ7 ABC transporter HPS44_04115 ENOG4105D64 Mechanosensitive ion channel HPS44_04125 ENOG4107QP8 phosphohexose isomerase HPS44_04135 ENOG4108Z9Z response to DNA damage stimulus HPS44_04160 ENOG4105X23 Endonuclease Exonuclease phosphatase HPS44_04165 ENOG4105DZQ phospholipase D Transphosphatidylase HPS44_04170 ENOG4107UXM Membrane HPS44_04175 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HPS44_04180 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HPS44_04185 ENOG4105CG3 alpha amylase, catalytic region HPS44_04200 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HPS44_04205 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HPS44_04215 ENOG4105C85 amino acid HPS44_04230 ENOG4105DQE DNA ligase HPS44_04235 ENOG4105FDF Could be involved in DNA repair (By similarity) HPS44_04240 ENOG4105CEV competence damage-inducible protein HPS44_04250 ENOG4105BZU Histidine kinase HPS44_04280 ENOG4107S4Y M20 DapE family protein YgeY HPS44_04300 ENOG4105CSH Transporter HPS44_04310 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HPS44_04315 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HPS44_04330 ENOG4108W0P ABC transporter HPS44_04335 ENOG4105EHG Permease protein HPS44_04355 ENOG4108UAJ Transcriptional regulator HPS44_04380 ENOG4105J4Q Transcriptional regulator HPS44_04385 ENOG4105ERH Fumarylacetoacetate hydrolase HPS44_04390 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HPS44_04400 ENOG4105E2X shikimate dehydrogenase HPS44_04405 ENOG4108IUS Transketolase HPS44_04410 ENOG4108HHA Transketolase HPS44_04415 ENOG4108WYP Transcriptional regulator HPS44_04420 ENOG4105DCT glycerol dehydrogenase HPS44_04425 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme HPS44_04430 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HPS44_04435 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HPS44_04445 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_04450 ENOG4105C0Z ABC transporter HPS44_04455 ENOG4108IV0 ABC, transporter HPS44_04465 ENOG4105CHR reductase HPS44_04480 ENOG4105JQN Transcriptional regulator HPS44_04495 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HPS44_04500 ENOG4105HEI LysR family (Transcriptional regulator HPS44_04505 ENOG4107QM5 aconitate hydratase HPS44_04510 ENOG4105UYK outer membrane protein a HPS44_04515 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HPS44_04530 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HPS44_04545 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_04615 ENOG4105BZU Histidine kinase HPS44_04635 ENOG4108JQ6 ABC transporter HPS44_04640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_04660 ENOG4105D7N magnesium and cobalt transport protein CorA HPS44_04680 ENOG4108JPW Aminotransferase HPS44_04685 ENOG4105C26 Dehydrogenase HPS44_04690 ENOG4105ECY inositol monophosphatase HPS44_04695 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HPS44_04700 ENOG4105D7W serine acetyltransferase HPS44_04705 ENOG4105CMR udp-glucose 4-epimerase HPS44_04710 ENOG4107QP8 phosphohexose isomerase HPS44_04715 ENOG4107QKV phosphomannomutase HPS44_04730 ENOG4105D3Q Sugar transferase HPS44_04735 ENOG4105FGF GDP-mannose mannosyl hydrolase HPS44_04740 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HPS44_04755 ENOG4105C30 Nad-dependent epimerase dehydratase HPS44_04775 ENOG4107T8Q Glycosyl transferase (Group 1 HPS44_04780 ENOG4106WTF Glycosyl transferase, family 2 HPS44_04785 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HPS44_04790 ENOG4106CD9 glycosyl transferase group 1 HPS44_04795 ENOG4105WH1 Two component transcriptional regulator luxr family HPS44_04800 ENOG4105WH1 Two component transcriptional regulator luxr family HPS44_04810 ENOG4108XG4 DNA-binding transcriptional regulator HPS44_04815 ENOG4107QPN acyl-Coa dehydrogenase HPS44_04825 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_04840 ENOG4105CHU acetyl-coa acetyltransferase HPS44_04855 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_04875 ENOG4105BZ1 (ABC) transporter HPS44_04880 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HPS44_04910 ENOG4105E39 Enoyl-CoA hydratase HPS44_04920 ENOG4105J4Q Transcriptional regulator HPS44_04925 ENOG4108T2C cysteine dioxygenase type I HPS44_04930 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HPS44_04950 ENOG4105HEI LysR family (Transcriptional regulator HPS44_04990 ENOG4108IJ6 ABC transporter HPS44_04995 ENOG4108RZE Tetr family transcriptional regulator HPS44_05010 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) HPS44_05020 ENOG4105BZU Histidine kinase HPS44_05025 ENOG4105BZU Histidine kinase HPS44_05030 ENOG4105BZU Histidine kinase HPS44_05050 ENOG4105NQN cytochrome C HPS44_05065 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i HPS44_05085 ENOG4105C58 cytochrome c oxidase accessory protein ccog HPS44_05105 ENOG4105ED4 portal protein HPS44_05285 ENOG4105CFH Aspartokinase HPS44_05290 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HPS44_05295 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HPS44_05305 ENOG4105C8N cysteinyl-tRNA synthetase HPS44_05320 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HPS44_05325 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HPS44_05330 ENOG4105EE5 Membrane protein terC HPS44_05340 ENOG4105HEE Binding Domain protein HPS44_05345 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) HPS44_05355 ENOG4105CIG ABC transporter HPS44_05360 ENOG4108T0W nitrous oxide maturation protein NosY HPS44_05370 ENOG4105CJ2 (LipO)protein HPS44_05375 ENOG4105DFS Conserved Protein HPS44_05380 ENOG4105ECY inositol monophosphatase HPS44_05400 ENOG4105D64 Mechanosensitive ion channel HPS44_05440 ENOG4105GVF (ABC) transporter HPS44_05450 ENOG4108IY8 ABC, transporter HPS44_05485 ENOG4105WKW Pfam:DUF1458 HPS44_05495 ENOG4105CC0 LysR family Transcriptional regulator HPS44_05500 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HPS44_05550 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HPS44_05555 ENOG4105EZE Cupin 4 family protein HPS44_05565 ENOG4105GJM (LipO)protein HPS44_05570 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_05575 ENOG4108Z4T Peptidase M50 HPS44_05580 ENOG4107RTD sua5 ycio yrdc ywlc family protein HPS44_05585 ENOG4105CGZ zinc metallopeptidase HPS44_05645 ENOG4108Z7R Chaperone CsaA HPS44_05650 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HPS44_05660 ENOG4105GTN ParB Domain Protein Nuclease HPS44_05665 ENOG4105DHQ Histidine kinase HPS44_05670 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_05690 ENOG4108TTM chaperone HPS44_05705 ENOG4105BZU Histidine kinase HPS44_05710 ENOG4105BZU Histidine kinase HPS44_05715 ENOG41068CG regulatoR HPS44_05745 ENOG4108S1B Periplasmic chaperone protein HPS44_05750 ENOG4105E6S usher protein( HPS44_05790 ENOG4105BZP glycoside hydrolase 15-related HPS44_05805 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_05815 ENOG4108NIW Leucine export protein LeuE HPS44_05830 ENOG4105DZQ phospholipase D Transphosphatidylase HPS44_05850 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPS44_05865 ENOG4107XBN GntR Family Transcriptional Regulator HPS44_05875 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPS44_05880 ENOG4105C0H protease HPS44_05910 ENOG4105E0F Histidine kinase HPS44_05915 ENOG4108ZHJ Organic hydroperoxide resistance protein HPS44_05920 ENOG4105RQF LysR family Transcriptional regulator HPS44_05930 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_05935 ENOG4105C3U ABC transporter HPS44_05955 ENOG4108Z9W Outer membrane porin HPS44_05960 ENOG4108KF1 Membrane HPS44_05965 ENOG4107SQD Transcriptional regulator, GntR family HPS44_05970 ENOG4105RHY Pfam:UPF0157 HPS44_06015 ENOG4105BZU Histidine kinase HPS44_06020 ENOG4105WEF catalase HPS44_06055 ENOG4108C33 Resolvase HPS44_06080 ENOG4105CJP fad dependent oxidoreductase HPS44_06085 ENOG4105DRP amino acid AbC transporter HPS44_06095 ENOG4105EAB amino acid AbC transporter HPS44_06105 ENOG4105C26 Dehydrogenase HPS44_06125 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HPS44_06150 ENOG4105C58 cytochrome c oxidase accessory protein ccog HPS44_06170 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i HPS44_06185 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPS44_06190 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HPS44_06200 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HPS44_06205 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HPS44_06230 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HPS44_06235 ENOG4105CA0 peroxidase HPS44_06240 ENOG4105EJC lysr family transcriptional regulator HPS44_06245 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HPS44_06255 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HPS44_06270 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HPS44_06275 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HPS44_06280 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_06285 ENOG4105BZS acriflavin resistance protein HPS44_06290 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPS44_06310 ENOG4105F4R Transcriptional regulator mode HPS44_06315 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_06320 ENOG4105E0C molybdate abc transporter HPS44_06325 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HPS44_06330 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HPS44_06365 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPS44_06375 ENOG4105C7J ABC transporter, permease HPS44_06385 ENOG4105CPC Aldo Keto reductase HPS44_06395 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_06400 ENOG4105E39 Enoyl-CoA hydratase HPS44_06410 ENOG4105DRR Transcriptional regulator, GntR family HPS44_06420 ENOG4105CHU acetyl-coa acetyltransferase HPS44_06425 ENOG4105D2B acyl-CoA dehydrogenase HPS44_06430 ENOG4105D2B acyl-CoA dehydrogenase HPS44_06435 ENOG4105DUM transcriptional regulator, lysR family HPS44_06455 ENOG4105TW1 Carbohydrate-selective porin OprB HPS44_06460 ENOG4105DFW ABC transporter HPS44_06470 ENOG4108HWW ABC transporter HPS44_06475 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HPS44_06480 ENOG4105E9Z Nad-dependent epimerase dehydratase HPS44_06485 ENOG4105ETE Transcriptional regulator (LacI family HPS44_06495 ENOG4108IJ7 Glycine betaine HPS44_06500 ENOG4108HQS Glycine betaine HPS44_06510 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HPS44_06515 ENOG4105C2C drug resistance transporter, Bcr CflA HPS44_06520 ENOG4105KDC 50s ribosomal protein l28 HPS44_06525 ENOG4105W0E 50S ribosomal protein L33 HPS44_06540 ENOG4105C0Z ABC transporter HPS44_06560 ENOG4105DZ1 carboxypeptidase HPS44_06570 ENOG4108VHT MarR family transcriptional regulator HPS44_06580 ENOG4105C8T Leucyl-tRNA synthetase HPS44_06595 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HPS44_06615 ENOG4105EUF amidase EC 3.5.1.4 HPS44_06625 ENOG4105C57 major facilitator superfamily HPS44_06635 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HPS44_06660 ENOG4105MP9 class II Aldolase HPS44_06700 ENOG4105ETT transcriptional Regulator, LysR family HPS44_06705 ENOG4105CYC Transferase HPS44_06710 ENOG4105CMU LysR family (Transcriptional regulator HPS44_06715 ENOG4105EGS Mechanosensitive ion channel HPS44_06745 ENOG4107SDU Methyl-accepting chemotaxis HPS44_06765 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_06775 ENOG4105D38 putrescine abc transporter HPS44_06780 ENOG4105CTU Proline racemase HPS44_06795 ENOG41080XP Cbs domain HPS44_06815 ENOG4107QIJ Aconitate hydratase 2 HPS44_06825 ENOG4105FQ6 thiopurine methyltransferase HPS44_06850 ENOG4105CPC Aldo Keto reductase HPS44_06855 ENOG4105CF7 AraC family transcriptional regulator HPS44_06865 ENOG4105K6V RNA polymerase HPS44_06880 ENOG4105Z2P Protein of unknown function (DUF465) HPS44_06895 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPS44_06900 ENOG4105CPK Glycosyl transferase (Group 1 HPS44_06915 ENOG4105D2S major facilitator superfamily HPS44_06920 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HPS44_06925 ENOG4105E2Z phosphate ABC transporter (Permease HPS44_06930 ENOG4105C8U phosphate abc transporter HPS44_06935 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HPS44_06945 ENOG4105C9X ppx gppa phosphatase HPS44_06955 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HPS44_06965 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPS44_06970 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HPS44_06975 ENOG4105HBR Rna-binding protein HPS44_06980 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HPS44_06985 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_06990 ENOG4105C2W permease HPS44_07000 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HPS44_07010 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_07025 ENOG4105EMU Dehydrogenase HPS44_07035 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HPS44_07040 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HPS44_07055 ENOG4105BZU Histidine kinase HPS44_07060 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPS44_07075 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HPS44_07085 ENOG4105D2X ABC transporter substrate-binding protein HPS44_07090 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_07105 ENOG4107QMP dna polymerase iii subunits gamma and tau HPS44_07115 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HPS44_07135 ENOG4105EA8 2-Nitropropane dioxygenase HPS44_07155 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_07170 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HPS44_07175 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_07190 ENOG41061WM D-Alanyl-D-Alanine HPS44_07210 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HPS44_07215 ENOG4108Z66 YbaK ebsC protein HPS44_07220 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPS44_07225 ENOG4105ETT transcriptional Regulator, LysR family HPS44_07230 ENOG4105C7K acetolactate synthase HPS44_07235 ENOG4105C1G acyl-Coa dehydrogenase HPS44_07275 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HPS44_07300 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_07310 ENOG4105C0Z ABC transporter HPS44_07315 ENOG4108IV0 ABC, transporter HPS44_07325 ENOG4107QXX ABC transporter HPS44_07340 ENOG4107QNJ CoA-transferase subunit B HPS44_07345 ENOG4107HP6 Transcriptional regulator HPS44_07350 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HPS44_07355 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HPS44_07360 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HPS44_07365 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HPS44_07375 ENOG4105C8V SAICAR synthetase HPS44_07395 ENOG4105CK2 sodium dicarboxylate symporter HPS44_07405 ENOG4105FD8 phosphonate metabolism protein PhnM HPS44_07410 ENOG4105HRV phosphonate c-p lyase system protein phnl HPS44_07415 ENOG4105ENV phosphonate C-P lyase system protein PhnK HPS44_07420 ENOG4105FT8 Phosphonate metabolism HPS44_07430 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HPS44_07435 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HPS44_07440 ENOG4107RJJ Transcriptional regulator HPS44_07445 ENOG4105FD8 phosphonate metabolism protein PhnM HPS44_07450 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HPS44_07455 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HPS44_07460 ENOG410811B TRANSCRIPTIONal HPS44_07465 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPS44_07485 ENOG4105EHI Phosphonate ABC transporter, periplasmic HPS44_07490 ENOG4105D5T phosphonate abc transporter HPS44_07500 ENOG4105MHT Transcriptional regulator, ARSR family HPS44_07510 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HPS44_07520 ENOG4105DR5 peptidase HPS44_07530 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPS44_07540 ENOG4105CJ3 phosphate transporter HPS44_07565 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) HPS44_07575 ENOG4108SHQ Glutathione S-transferase HPS44_07595 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPS44_07600 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HPS44_07615 ENOG4105BZA Phosphoglycerate kinase HPS44_07620 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPS44_07625 ENOG4105CV1 Transketolase (EC 2.2.1.1) HPS44_07635 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HPS44_07650 ENOG4105C6K Malic enzyme HPS44_07675 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HPS44_07680 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HPS44_07695 ENOG4105TNS Conserved Protein HPS44_07705 ENOG4105D7T ABC transporter HPS44_07715 ENOG4105I5W Transporter HPS44_07720 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HPS44_07725 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HPS44_07730 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HPS44_07755 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HPS44_07760 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HPS44_07775 ENOG4105VIE preprotein translocase, subunit YajC HPS44_07780 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPS44_07785 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPS44_07805 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPS44_07825 ENOG4105C9A Phoh family HPS44_07830 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HPS44_07835 ENOG4108JU5 Magnesium and cobalt efflux protein HPS44_07840 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HPS44_07845 ENOG4107SET aldo keto reductase HPS44_07880 ENOG4108UAJ Transcriptional regulator HPS44_07890 ENOG4108TZV Membrane HPS44_07910 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HPS44_07920 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPS44_07930 ENOG4108ZAF Molybdopterin HPS44_07935 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPS44_07940 ENOG4105CVM Molybdenum cofactor synthesis domain protein HPS44_07950 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPS44_07965 ENOG4107QIZ NADH dehydrogenase HPS44_07970 ENOG4108IEG Formate dehydrogenase Alpha subunit HPS44_07975 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HPS44_08010 ENOG4106NZI LysR family Transcriptional regulator HPS44_08015 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HPS44_08020 ENOG41068KF Universal stress protein HPS44_08030 ENOG4105IFJ Histidine kinase HPS44_08035 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_08050 ENOG4105E3J oxidoreductase HPS44_08065 ENOG4105CHR reductase HPS44_08085 ENOG4105C7F AcnD-accessory protein PrpF HPS44_08090 ENOG4105F04 LysR family Transcriptional regulator HPS44_08130 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HPS44_08135 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_08145 ENOG4105C0Z ABC transporter HPS44_08150 ENOG4108IV0 ABC, transporter HPS44_08160 ENOG4105E0K tonB-dependent siderophore receptor HPS44_08175 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HPS44_08180 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPS44_08190 ENOG4108VPT UPF0234 protein HPS44_08195 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HPS44_08200 ENOG4105EHG Permease protein HPS44_08205 ENOG4107R4I Periplasmic binding protein HPS44_08210 ENOG4106QJH hemin transport protein HPS44_08220 ENOG4108S3W Anti-feci sigma factor, fecr HPS44_08225 ENOG4108SF5 RNA Polymerase HPS44_08240 ENOG4105D29 Helix-turn-helix type 11 domain protein HPS44_08265 ENOG4105CBN LysR family transcriptional regulator HPS44_08270 ENOG4105C85 amino acid HPS44_08280 ENOG4105F7P transcriptional regulator AsnC family HPS44_08285 ENOG4108UT2 hemolysin iii HPS44_08290 ENOG4105KXX peptidase s58 dmpa HPS44_08295 ENOG4105EAB amino acid AbC transporter HPS44_08300 ENOG4105E5Q amino acid AbC transporter HPS44_08305 ENOG4105CDA abc transporter atp-binding protein HPS44_08310 ENOG4108K5P (LipO)protein HPS44_08340 ENOG4105TX3 Histidine kinase HPS44_08345 ENOG4108UYB regulatoR HPS44_08350 ENOG4105E2S oxidase) subunit II HPS44_08355 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPS44_08360 ENOG4105CCU oxidase (Subunit III) HPS44_08365 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HPS44_08405 ENOG4105C6K Malic enzyme HPS44_08420 ENOG4108PCN EamA-like transporter family HPS44_08440 ENOG4105DUM transcriptional regulator, lysR family HPS44_08455 ENOG4105CHR reductase HPS44_08465 ENOG4107NQ8 LysR family Transcriptional regulator HPS44_08485 ENOG4108JCI Transcriptional regulator HPS44_08490 ENOG4107RZC phospholipase d HPS44_08500 ENOG4105CF1 Alkylated DNA repair protein HPS44_08515 ENOG4105E6M Sulphatase-modifying factor protein HPS44_08530 ENOG4105F1J Homogentisate 1,2-dioxygenase HPS44_08535 ENOG4108302 MgtC SapB transporter HPS44_08540 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HPS44_08545 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HPS44_08560 ENOG4107QM5 aconitate hydratase HPS44_08575 ENOG4108S3W Anti-feci sigma factor, fecr HPS44_08580 ENOG4108SF5 RNA Polymerase HPS44_08585 ENOG4108MP6 LysR family Transcriptional regulator HPS44_08590 ENOG4107GJV short-chain dehydrogenase reductase HPS44_08595 ENOG4105CNM Receptor HPS44_08615 ENOG4105BZU Histidine kinase HPS44_08620 ENOG4105EPW hflc protein HPS44_08635 ENOG4105D4Y metalloprotease HPS44_08645 ENOG4105DJ2 Major Facilitator Superfamily HPS44_08650 ENOG4105R1U AraC Family Transcriptional Regulator HPS44_08655 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HPS44_08665 ENOG4105DU1 integral membrane protein, terc HPS44_08670 ENOG41063Z6 transcriptional regulator, lysR family HPS44_08700 ENOG41067B5 Histone deacetylase superfamily protein HPS44_08720 ENOG4105CSH Transporter HPS44_08725 ENOG4105E2S oxidase) subunit II HPS44_08730 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPS44_08735 ENOG4105CCU oxidase (Subunit III) HPS44_08740 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HPS44_08750 ENOG4108Z9W Outer membrane porin HPS44_08755 ENOG4108Z9W Outer membrane porin HPS44_08760 ENOG4108Z9W Outer membrane porin HPS44_08770 ENOG4105E5M Multidrug resistance protein D HPS44_08825 ENOG4105HSS phospholipase C HPS44_08850 ENOG4107QZF nitrite reductase NADPH large subunit HPS44_08855 ENOG4107QZF nitrite reductase NADPH large subunit HPS44_08860 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HPS44_08870 ENOG4105CPC Aldo Keto reductase HPS44_08885 ENOG4105CV8 reductase HPS44_08890 ENOG4105HEI LysR family (Transcriptional regulator HPS44_08910 ENOG4105EJC lysr family transcriptional regulator HPS44_08915 ENOG4105CMJ mandelate racemase muconate lactonizing HPS44_08930 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_08935 ENOG410620I Diguanylate cyclase HPS44_08940 ENOG4105MHT Transcriptional regulator, ARSR family HPS44_08950 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HPS44_08955 ENOG4105C6X Major Facilitator HPS44_08985 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_08995 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HPS44_09000 ENOG4105K5X acetyltransferase HPS44_09005 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HPS44_09020 ENOG4108M0I Transcriptional regulator HPS44_09030 ENOG4105MP9 class II Aldolase HPS44_09070 ENOG4105PGM cation diffusion facilitator family transporter HPS44_09090 ENOG4105BZ1 (ABC) transporter HPS44_09100 ENOG4107QRT dEAD DEAH box helicase HPS44_09105 ENOG4107T0X DNA ligase HPS44_09110 ENOG4107T0X DNA ligase HPS44_09140 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HPS44_09145 ENOG4105C1G acyl-Coa dehydrogenase HPS44_09155 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_09160 ENOG4108PCN EamA-like transporter family HPS44_09165 ENOG4105CWC Acetylornithine deacetylase HPS44_09185 ENOG4105C5Q Transcriptional regulator HPS44_09190 ENOG410642W LysR family Transcriptional regulator HPS44_09215 ENOG4105F52 Transcriptional regulator HPS44_09220 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_09230 ENOG4105CMJ mandelate racemase muconate lactonizing HPS44_09240 ENOG4108Z9W Outer membrane porin HPS44_09245 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_09290 ENOG4108SF5 RNA Polymerase HPS44_09315 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPS44_09320 ENOG4105BZU Histidine kinase HPS44_09325 ENOG4105BZU Histidine kinase HPS44_09330 ENOG4107Z5C methylesterase HPS44_09335 ENOG4105BZU Histidine kinase HPS44_09375 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HPS44_09405 ENOG4105BZU Histidine kinase HPS44_09425 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPS44_09430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_09440 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HPS44_09445 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HPS44_09455 ENOG4108U05 Transcriptional regulator HPS44_09470 ENOG4105DUM transcriptional regulator, lysR family HPS44_09500 ENOG4108IUZ ABC transporter HPS44_09505 ENOG4108IV0 ABC, transporter HPS44_09510 ENOG4105DEI Mannitol dehydrogenase HPS44_09515 ENOG41080IJ Diacylglycerol kinase HPS44_09520 ENOG4105CEP NADH dehydrogenase HPS44_09525 ENOG4105SKN orotidine 5''-phosphate decarboxylase HPS44_09530 ENOG4107TH8 cina domain protein HPS44_09540 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HPS44_09545 ENOG4107YIM Involved in the transcription termination process (By similarity) HPS44_09550 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HPS44_09555 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HPS44_09575 ENOG4105D5T phosphonate abc transporter HPS44_09600 ENOG4106H78 methyltransferase HPS44_09605 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HPS44_09610 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HPS44_09615 ENOG4105DKK Benzoate HPS44_09650 ENOG4105CNM Receptor HPS44_09655 ENOG4105DFS Conserved Protein HPS44_09660 ENOG4105C3G gtp-binding protein HPS44_09670 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HPS44_09690 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HPS44_09695 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_09705 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein HPS44_09710 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HPS44_09735 ENOG4105F1J Homogentisate 1,2-dioxygenase HPS44_09745 ENOG4106HNH Acyl-transferase HPS44_09750 ENOG4105E0M Sulfatase HPS44_09755 ENOG4107YCY Transcriptional regulator HPS44_09760 ENOG4105E9Z Nad-dependent epimerase dehydratase HPS44_09770 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPS44_09780 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_09790 ENOG4105BZU Histidine kinase HPS44_09795 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_09800 ENOG4105CQB FAD linked oxidase domain protein HPS44_09815 ENOG4107QP8 phosphohexose isomerase HPS44_09820 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPS44_09825 ENOG4105CGN Glycosyl transferase (Group 1 HPS44_09830 ENOG4108KMV Glycosyl transferase (Group 1 HPS44_09835 ENOG4107STW synthase HPS44_09845 ENOG4105CG5 Glycosyl transferase (Group 1 HPS44_09860 ENOG4107QQG Dehydrogenase HPS44_09865 ENOG4107UKG Glycosyl transferase, family 4 HPS44_09885 ENOG4105BZU Histidine kinase HPS44_09895 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_09900 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPS44_09905 ENOG4105C26 Dehydrogenase HPS44_09930 ENOG4108JQ6 ABC transporter HPS44_09935 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPS44_09975 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HPS44_09980 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HPS44_09985 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HPS44_09995 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPS44_10000 ENOG4105CBX hi0933 family HPS44_10005 ENOG4105CXN decarboxylase HPS44_10020 ENOG4105BZU Histidine kinase HPS44_10030 ENOG4105DHP deoxycytidine triphosphate deaminase HPS44_10055 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HPS44_10060 ENOG4105C72 UPF0176 protein HPS44_10075 ENOG4105EXC Acyl-transferase HPS44_10085 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_10090 ENOG4107SVH Potassium channel protein HPS44_10095 ENOG4105CXC rtn protein HPS44_10100 ENOG4108SF5 RNA Polymerase HPS44_10110 ENOG4105E0K tonB-dependent siderophore receptor HPS44_10120 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class HPS44_10125 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_10130 ENOG4105D0S secretion protein (HlyD HPS44_10135 ENOG4105CJ1 ABC, transporter HPS44_10140 ENOG4105CMI transporter HPS44_10150 ENOG4105CHR reductase HPS44_10155 ENOG4105CC0 LysR family Transcriptional regulator HPS44_10160 ENOG4108KTG Membrane protein, drug metabolite transporter HPS44_10170 ENOG4105C4M (Ubiquinol oxidase) subunit I HPS44_10175 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPS44_10185 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_10205 ENOG41079YP Citrate utilization protein b HPS44_10220 ENOG4105NQN cytochrome C HPS44_10230 ENOG4105CYM Glutathione S-transferase HPS44_10235 ENOG4105C84 Histidine ammonia-lyase HPS44_10240 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HPS44_10245 ENOG4105CSH Transporter HPS44_10250 ENOG4105CGP Urocanate hydratase HPS44_10265 ENOG4105CD3 dihydroorotase HPS44_10290 ENOG4105YK5 50S ribosomal protein L36 HPS44_10300 ENOG4108I0Z Aconitate hydratase HPS44_10305 ENOG4105C7F AcnD-accessory protein PrpF HPS44_10310 ENOG4108SF5 RNA Polymerase HPS44_10315 ENOG4108S3W Anti-feci sigma factor, fecr HPS44_10320 ENOG4105CNM Receptor HPS44_10325 ENOG4105CH7 arginosuccinase HPS44_10330 ENOG4105JJR Histidine kinase HPS44_10335 ENOG4105CHR reductase HPS44_10340 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme HPS44_10355 ENOG4105EVD ribosomal RNA large subunit methyltransferase N HPS44_10360 ENOG4105JSC dimethylmenaquinone methyltransferase HPS44_10365 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPS44_10370 ENOG4105BZN citrate synthase HPS44_10375 ENOG4105CXK mandelate racemase muconate lactonizing HPS44_10400 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HPS44_10405 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_10415 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HPS44_10425 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HPS44_10435 ENOG4109066 lysm domain bon superfamily protein HPS44_10440 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HPS44_10445 ENOG4105CRE cytochrome C HPS44_10460 ENOG4108TGY Glutathione S-transferase HPS44_10490 ENOG4105C26 Dehydrogenase HPS44_10500 ENOG4105DFG type I secretion outer membrane protein HPS44_10505 ENOG4107QZV Type I secretion membrane fusion protein HPS44_10510 ENOG4108JJ6 Type I secretion system ATPase HPS44_10540 ENOG4107HP6 Transcriptional regulator HPS44_10550 ENOG4108RTU Aldolase HPS44_10555 ENOG4105CXK mandelate racemase muconate lactonizing HPS44_10560 ENOG4105DJB Major Facilitator Superfamily HPS44_10565 ENOG4105CJ1 ABC, transporter HPS44_10585 ENOG4105F27 Major Facilitator HPS44_10590 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HPS44_10600 ENOG4105C2W permease HPS44_10630 ENOG4108R1E Serine threonine protein phosphatase 1 HPS44_10695 ENOG4105VUH addiction module killer protein HPS44_10710 ENOG4107QXX ABC transporter HPS44_10720 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HPS44_10735 ENOG4105CHR reductase HPS44_10845 ENOG4105BZU Histidine kinase HPS44_10850 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_10855 ENOG4105I6B RNA polymerase HPS44_10875 ENOG4106NZI LysR family Transcriptional regulator HPS44_10885 ENOG4105NTW Transcriptional regulator HPS44_10905 ENOG4105II7 pyrroline-5-carboxylate reductase HPS44_10915 ENOG4105CQB FAD linked oxidase domain protein HPS44_10925 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_10930 ENOG4105F38 ABC transporter, permease HPS44_10935 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_10950 ENOG4105IPI Membrane HPS44_10955 ENOG4105CBN LysR family transcriptional regulator HPS44_10960 ENOG4105ENT Efflux transporter rnd family, mfp subunit HPS44_10970 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_11010 ENOG4105GP2 5'(3')-deoxyribonucleotidase HPS44_11020 ENOG4107YCY Transcriptional regulator HPS44_11030 ENOG4105E2X shikimate dehydrogenase HPS44_11040 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_11050 ENOG4105C0Z ABC transporter HPS44_11055 ENOG4108IV0 ABC, transporter HPS44_11065 ENOG4108JYK Dehydrogenase HPS44_11085 ENOG4105HEI LysR family (Transcriptional regulator HPS44_11090 ENOG4105C01 Dihydroxy-acid dehydratase HPS44_11100 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HPS44_11105 ENOG4105DUM transcriptional regulator, lysR family HPS44_11120 ENOG4105CXC rtn protein HPS44_11125 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HPS44_11130 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HPS44_11135 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_11140 ENOG4105CRW Short chain fatty acid transporter HPS44_11145 ENOG4105CHR reductase HPS44_11150 ENOG4107HP6 Transcriptional regulator HPS44_11160 ENOG4107QNJ CoA-transferase subunit B HPS44_11175 ENOG4105F2Z 3-oxoadipate enol-lactonase HPS44_11200 ENOG4108PVQ transcriptional regulator HPS44_11205 ENOG4105CHR reductase HPS44_11215 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_11220 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_11225 ENOG4105C0Z ABC transporter HPS44_11230 ENOG4108IV0 ABC, transporter HPS44_11240 ENOG4105CHR reductase HPS44_11245 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HPS44_11250 ENOG4108U78 Glutathione S-transferase HPS44_11275 ENOG4107NQ8 LysR family Transcriptional regulator HPS44_11280 ENOG4105C57 major facilitator superfamily HPS44_11305 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_11325 ENOG4105D01 (LipO)protein HPS44_11335 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HPS44_11345 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HPS44_11350 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HPS44_11365 ENOG410829K Lysine exporter protein (Lyse ygga) HPS44_11390 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HPS44_11395 ENOG4105UGU tonB-dependent Receptor HPS44_11405 ENOG4105CSH Transporter HPS44_11410 ENOG4105DDW LysR family Transcriptional regulator HPS44_11415 ENOG4107YCY Transcriptional regulator HPS44_11420 ENOG4105G63 Type III effector Hrp-dependent HPS44_11425 ENOG4105ZXK Dehydrogenase HPS44_11430 ENOG4105EXW epimerase dehydratase HPS44_11435 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HPS44_11440 ENOG4105FB2 class II Aldolase HPS44_11510 ENOG4105EAH synthase HPS44_11515 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HPS44_11520 ENOG4105K46 50S ribosomal protein l27 HPS44_11525 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HPS44_11530 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HPS44_11545 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPS44_11550 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HPS44_11560 ENOG4108QBF Transcriptional regulator HPS44_11565 ENOG4105BZU Histidine kinase HPS44_11570 ENOG4105D06 uba thif-type nad fad binding protein HPS44_11575 ENOG4105CN1 protease HPS44_11580 ENOG41063SB peptidase HPS44_11585 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HPS44_11590 ENOG4105C72 UPF0176 protein HPS44_11595 ENOG4105VW4 glutaredoxin 3 HPS44_11600 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HPS44_11605 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HPS44_11620 ENOG4105MJ2 Competence protein HPS44_11625 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPS44_11630 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HPS44_11635 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HPS44_11640 ENOG4105C1A potassium transporter peripheral membrane HPS44_11645 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_11650 ENOG4105ES5 Histidine kinase HPS44_11660 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HPS44_11665 ENOG410829K Lysine exporter protein (Lyse ygga) HPS44_11670 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HPS44_11680 ENOG4105KVH Transcriptional regulator HPS44_11690 ENOG4108URH decarboxylase HPS44_11700 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 HPS44_11710 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HPS44_11715 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HPS44_11720 ENOG4105C79 DNA protecting protein DprA HPS44_11725 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HPS44_11735 ENOG4107QXX ABC transporter HPS44_11740 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_11745 ENOG4105DFA alanine racemase domain protein HPS44_11765 ENOG4105W39 Membrane HPS44_11770 ENOG4105C7B Threonine dehydratase HPS44_11775 ENOG4108Z9W Outer membrane porin HPS44_11785 ENOG4105EXG Transcriptional regulator HPS44_11790 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HPS44_11795 ENOG4108JJ8 (ABC) transporter HPS44_11800 ENOG4108JJ9 ABC, transporter HPS44_11810 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPS44_11815 ENOG4105C4M (Ubiquinol oxidase) subunit I HPS44_11825 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HPS44_11830 ENOG4105C2X Arabinose 5-phosphate isomerase HPS44_11835 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HPS44_11850 ENOG4108IUZ ABC transporter HPS44_11855 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HPS44_11860 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HPS44_11865 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HPS44_11870 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_11885 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HPS44_11895 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPS44_11905 ENOG41082RQ UPF0102 protein HPS44_11910 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HPS44_11915 ENOG4105W4M Transport-associated protein HPS44_11920 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPS44_11925 ENOG4105D01 (LipO)protein HPS44_11930 ENOG4105CAS nag kinase HPS44_11940 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HPS44_11945 ENOG4107QPK )-transporter HPS44_11950 ENOG4105DG4 malate L-lactate dehydrogenase HPS44_11955 ENOG4105CNI cell division protein FtsW HPS44_11960 ENOG4105CJN penicillin-binding protein HPS44_11970 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HPS44_11980 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HPS44_11985 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPS44_11990 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HPS44_12005 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HPS44_12010 ENOG4105CGK Exodeoxyribonuclease III HPS44_12015 ENOG4105D82 Glutamate dehydrogenase HPS44_12025 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HPS44_12040 ENOG410810E transcriptional regulator, lysR family HPS44_12045 ENOG4105CP9 extracellular ligand-binding receptor HPS44_12055 ENOG4105C0Z ABC transporter HPS44_12060 ENOG4108IV0 ABC, transporter HPS44_12065 ENOG4108ZHJ Organic hydroperoxide resistance protein HPS44_12070 ENOG4105K56 Transcriptional regulator HPS44_12085 ENOG4105C0Z ABC transporter HPS44_12090 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_12105 ENOG4108IV0 ABC, transporter HPS44_12110 ENOG4105DZS Phenylacetate-CoA ligase HPS44_12130 ENOG41080HT Transcriptional regulator, arsr family HPS44_12140 ENOG4105CSR polyphosphate kinase 2 HPS44_12160 ENOG4105K78 MarR family Transcriptional regulator HPS44_12175 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HPS44_12185 ENOG4105DWF phosphomethylpyrimidine kinase HPS44_12220 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HPS44_12225 ENOG4105C1J atp-dependent rna helicase HPS44_12235 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HPS44_12240 ENOG4107SC1 transglycosylase HPS44_12245 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HPS44_12275 ENOG4105SYT Methylenetetrahydrofolate reductase HPS44_12280 ENOG41086DT Membrane protein of unknown function HPS44_12285 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HPS44_12290 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HPS44_12305 ENOG4108TFY Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HPS44_12320 ENOG4105EJC lysr family transcriptional regulator HPS44_12325 ENOG4105EW6 flavin reductase domain protein, FMN-binding HPS44_12355 ENOG4108IV0 ABC, transporter HPS44_12365 ENOG4105CSH Transporter HPS44_12370 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPS44_12375 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HPS44_12390 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HPS44_12400 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPS44_12405 ENOG4105D7X high-affinity nickel-transporter HPS44_12415 ENOG4105DSE periplasmic solute binding protein HPS44_12420 ENOG4105CC5 ABC transporter HPS44_12425 ENOG4105DIK (ABC) transporter HPS44_12430 ENOG4105MYN Zinc uptake regulation protein HPS44_12435 ENOG4105CKI cobalamin synthesis protein HPS44_12445 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HPS44_12450 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HPS44_12460 ENOG4108WBT adenosyltransferase HPS44_12465 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HPS44_12480 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HPS44_12485 ENOG4108Z43 UPF0250 protein HPS44_12495 ENOG4105DZ1 carboxypeptidase HPS44_12520 ENOG4105CY3 ABC transporter, permease HPS44_12530 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HPS44_12540 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HPS44_12545 ENOG4105D16 lipopolysaccharide heptosyltransferase i HPS44_12555 ENOG4105J5G Transferase hexapeptide repeat containing protein HPS44_12560 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPS44_12570 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPS44_12580 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HPS44_12600 ENOG4107EF8 Glycosyl transferase (Group 1 HPS44_12605 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPS44_12610 ENOG4105CAQ asparagine synthetase HPS44_12635 ENOG4105CMR udp-glucose 4-epimerase HPS44_12640 ENOG4105CMR udp-glucose 4-epimerase HPS44_12645 ENOG4105CAQ asparagine synthetase HPS44_12665 ENOG4105EY8 ABC transporter HPS44_12680 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HPS44_12700 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HPS44_12720 ENOG4105CAQ asparagine synthetase HPS44_12725 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPS44_12750 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HPS44_12765 ENOG4105DZQ phospholipase D Transphosphatidylase HPS44_12770 ENOG4105X23 Endonuclease Exonuclease phosphatase HPS44_12775 ENOG4105C9M aspartyl-trna synthetase HPS44_12800 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPS44_12815 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_12820 ENOG4108ZGC gaf domain protein HPS44_12825 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_12850 ENOG4108KWP DNA-binding transcriptional regulator GlcC HPS44_12855 ENOG4107QP3 malate synthase g HPS44_12885 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HPS44_12895 ENOG4107RDB Major Facilitator HPS44_12900 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPS44_12905 ENOG4108RXX maleylacetoacetate isomerase HPS44_12910 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HPS44_12915 ENOG4105D49 3-dehydroquinate synthase HPS44_12920 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HPS44_12925 ENOG4108JQC penicillin-binding protein 1A HPS44_12930 ENOG4105XQ6 frataxin-like protein HPS44_12940 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HPS44_12950 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HPS44_12960 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HPS44_12965 ENOG4105D52 delta-aminolevulinic acid dehydratase HPS44_12975 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HPS44_12980 ENOG4105VF7 tolerance protein HPS44_12990 ENOG4108ZT0 50S ribosomal protein l17 HPS44_12995 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HPS44_13000 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HPS44_13005 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HPS44_13010 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HPS44_13020 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HPS44_13025 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HPS44_13030 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HPS44_13035 ENOG4105VPB 50S ribosomal protein L30 HPS44_13040 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HPS44_13045 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HPS44_13050 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HPS44_13055 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HPS44_13060 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HPS44_13065 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HPS44_13070 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HPS44_13075 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HPS44_13090 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPS44_13105 ENOG4107RST alpha/beta hydrolase fold HPS44_13115 ENOG4105C0Z ABC transporter HPS44_13120 ENOG4105CDA abc transporter atp-binding protein HPS44_13125 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_13140 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HPS44_13145 ENOG41084PQ 50s ribosomal protein l29 HPS44_13150 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HPS44_13155 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HPS44_13160 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HPS44_13165 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HPS44_13170 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HPS44_13175 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HPS44_13185 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HPS44_13190 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HPS44_13195 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HPS44_13200 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HPS44_13205 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HPS44_13210 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HPS44_13215 ENOG4107EXC regulatoR HPS44_13230 ENOG4105BZU Histidine kinase HPS44_13245 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HPS44_13250 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HPS44_13255 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HPS44_13260 ENOG4108VZM 50s ribosomal protein L10 HPS44_13265 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HPS44_13270 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HPS44_13280 ENOG410683Z Preprotein translocase SecE subunit HPS44_13290 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HPS44_13330 ENOG4107QKW extracellular solute-binding protein family 1 HPS44_13335 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_13370 ENOG4107NQ8 LysR family Transcriptional regulator HPS44_13375 ENOG4105HDK L-asparaginase HPS44_13380 ENOG4105FA0 parb-like partition protein HPS44_13390 ENOG4107QJE Chromosome Partitioning Protein HPS44_13395 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HPS44_13400 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HPS44_13405 ENOG4105VEQ Cold shock protein HPS44_13410 ENOG4108KK1 membrane protein AbrB duplication HPS44_13415 ENOG4105CHM Aminotransferase HPS44_13455 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HPS44_13470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_13475 ENOG4105C3U ABC transporter HPS44_13480 ENOG4108JQ7 (ABC) transporter HPS44_13485 ENOG4105CH2 amidohydrolase HPS44_13500 ENOG4105C6T cysteine synthase HPS44_13505 ENOG4105CH6 catalase HPS44_13515 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HPS44_13525 ENOG4105VG0 50S ribosomal protein l34 HPS44_13530 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HPS44_13535 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HPS44_13540 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPS44_13545 ENOG4105CC0 LysR family Transcriptional regulator HPS44_13560 ENOG4105C2I pirin domain protein HPS44_13570 ENOG4105EFZ amidohydrolase HPS44_13580 ENOG4105RQF LysR family Transcriptional regulator HPS44_13585 ENOG4107RP9 extracellular solute-binding protein, family 3 HPS44_13590 ENOG4105EAD ABC transporter HPS44_13595 ENOG4105DRP amino acid AbC transporter HPS44_13600 ENOG4105CDA abc transporter atp-binding protein HPS44_13610 ENOG4108594 Permease of the drug metabolite transporter HPS44_13640 ENOG4105F38 ABC transporter, permease HPS44_13645 ENOG4105D38 putrescine abc transporter HPS44_13670 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HPS44_13700 ENOG4105CMD Transcriptional regulator, GntR family HPS44_13710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_13715 ENOG4105F38 ABC transporter, permease HPS44_13720 ENOG4105D38 putrescine abc transporter HPS44_13745 ENOG4105M4H endoribonuclease L-psp HPS44_13785 ENOG4105DZC cytosine deaminase HPS44_13795 ENOG4105UIB (ABC) transporter HPS44_13800 ENOG4108JQ9 ABC transporter HPS44_13805 ENOG4107TFB basic membrane HPS44_13815 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HPS44_13830 ENOG4108MEJ flavin reductase domain protein HPS44_13845 ENOG4105F9N Major Facilitator Superfamily HPS44_13860 ENOG4105FFC UPF0187 protein HPS44_13865 ENOG4108YXU transcriptional regulator AsnC family HPS44_13870 ENOG4105C7K acetolactate synthase HPS44_13875 ENOG4105CHR reductase HPS44_13880 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HPS44_13895 ENOG4105C9U ATP-dependent DNA helicase RecQ HPS44_13905 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HPS44_13910 ENOG4108RPN Protein smg homolog HPS44_13920 ENOG4105H1G trap transporter solute receptor taxi family HPS44_13940 ENOG4105E5Q amino acid AbC transporter HPS44_13945 ENOG4105E5Q amino acid AbC transporter HPS44_13950 ENOG4106TNF Periplasmic binding protein HPS44_13955 ENOG4105KWI UPF0339 protein HPS44_13965 ENOG4105C8Y Acetylornithine aminotransferase HPS44_14010 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HPS44_14040 ENOG4108NIW Leucine export protein LeuE HPS44_14065 ENOG4105JXH GntR family transcriptional regulator HPS44_14070 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPS44_14085 ENOG4108SF5 RNA Polymerase HPS44_14090 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_14105 ENOG4105CHR reductase HPS44_14135 ENOG4105E8G Major facilitator Superfamily HPS44_14150 ENOG4108WFR AraC Family Transcriptional Regulator HPS44_14170 ENOG4107QX3 carboxylase HPS44_14175 ENOG4105CHU acetyl-coa acetyltransferase HPS44_14180 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HPS44_14185 ENOG4105C1G acyl-Coa dehydrogenase HPS44_14190 ENOG4105CH2 amidohydrolase HPS44_14200 ENOG4105KK4 UPF0060 membrane protein HPS44_14215 ENOG410829K Lysine exporter protein (Lyse ygga) HPS44_14230 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HPS44_14250 ENOG4108Z33 Thiol disulfide Interchange Protein HPS44_14260 ENOG4105C75 arginyL-tRNA synthetase HPS44_14275 ENOG4105DRS transport system, permease HPS44_14280 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HPS44_14285 ENOG4105BZ7 extracellular solute-binding protein family 1 HPS44_14290 ENOG4108IJ9 (ABC) transporter HPS44_14295 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HPS44_14300 ENOG4105ETE Transcriptional regulator (LacI family HPS44_14310 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HPS44_14325 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPS44_14355 ENOG4108UQY Iron-storage protein HPS44_14365 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HPS44_14370 ENOG410829K Lysine exporter protein (Lyse ygga) HPS44_14375 ENOG4105C1J atp-dependent rna helicase HPS44_14380 ENOG4106J39 exported protein HPS44_14385 ENOG4106J39 exported protein HPS44_14390 ENOG4105CI2 imidazolone-5-propionate hydrolase HPS44_14400 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_14405 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPS44_14410 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_14415 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HPS44_14420 ENOG4105KD1 integral membrane protein HPS44_14425 ENOG4105UEI Transcriptional Regulator AraC Family HPS44_14435 ENOG4107QI6 Cysteine desulfurase HPS44_14445 ENOG4105ETT transcriptional Regulator, LysR family HPS44_14460 ENOG4105C6Z Gluconate HPS44_14475 ENOG4105KB2 stringent starvation protein b HPS44_14480 ENOG4107MKT Stringent starvation protein a HPS44_14485 ENOG4105EIX cytochrome c1 HPS44_14490 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HPS44_14495 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HPS44_14500 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HPS44_14505 ENOG4107QNR UPF0135 protein HPS44_14510 ENOG4105C0H protease HPS44_14525 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HPS44_14530 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HPS44_14535 ENOG4107YU2 histidine triad (hIT) protein HPS44_14540 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase HPS44_14550 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HPS44_14555 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HPS44_14560 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HPS44_14565 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HPS44_14570 ENOG4105CIH Imidazole acetol-phosphate transaminase HPS44_14575 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HPS44_14580 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HPS44_14585 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HPS44_14595 ENOG4105E3A (ABC) transporter HPS44_14600 ENOG4105DA5 (ABC) transporter HPS44_14610 ENOG410903C (LipO)protein HPS44_14615 ENOG4107PE3 Mammalian cell entry related domain protein HPS44_14620 ENOG4105CY3 ABC transporter, permease HPS44_14625 ENOG4105DHJ ABC, transporter HPS44_14630 ENOG4105EA8 2-Nitropropane dioxygenase HPS44_14640 ENOG4105CBP Major Facilitator HPS44_14645 ENOG4105EGI Transcriptional regulator HPS44_14650 ENOG4105EIF outer membrane protein W HPS44_14655 ENOG4105DND Transcriptional regulator HPS44_14660 ENOG4105E7W lamb ycsf family protein HPS44_14665 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HPS44_14670 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPS44_14715 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPS44_14720 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HPS44_14735 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HPS44_14740 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPS44_14750 ENOG4107QS1 Cytochrome C Oxidase, Subunit III HPS44_14770 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HPS44_14800 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HPS44_14805 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPS44_14810 ENOG4105C6Y Udp-glucose 6-dehydrogenase HPS44_14815 ENOG4105CG5 Glycosyl transferase (Group 1 HPS44_14830 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HPS44_14845 ENOG4108SUT Major Facilitator Superfamily HPS44_14860 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HPS44_14870 ENOG4106B0W Curli production assembly transport component CsgG HPS44_14880 ENOG4107Y60 (LipO)protein HPS44_14885 ENOG4108IYU L-aspartate oxidase HPS44_14890 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HPS44_14895 ENOG4105EQ0 Major Facilitator superfamily HPS44_14900 ENOG4105CR8 Transcriptional regulator HPS44_14910 ENOG4107QWB Ornithine cyclodeaminase HPS44_14915 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HPS44_14920 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HPS44_14925 ENOG4105EVZ LysR family transcriptional regulator HPS44_14930 ENOG4105CK7 Sodium proline symporter HPS44_14935 ENOG4105CYW agmatinase HPS44_14940 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HPS44_14995 ENOG4105CGH 5'-nucleotidase HPS44_15010 ENOG4105CZE histidine utilization repressor HPS44_15015 ENOG41090B9 response to stress HPS44_15020 ENOG4105CGP Urocanate hydratase HPS44_15025 ENOG4105ETS cytosine purines uracil thiamine allantoin HPS44_15040 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_15045 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPS44_15095 ENOG4105DRR Transcriptional regulator, GntR family HPS44_15110 ENOG4105C26 Dehydrogenase HPS44_15135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_15145 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_15155 ENOG4107T8P acyl-Coa dehydrogenase HPS44_15160 ENOG4107T8P acyl-Coa dehydrogenase HPS44_15170 ENOG4105D01 (LipO)protein HPS44_15175 ENOG4108UZX fmn reductase HPS44_15180 ENOG4105GVF (ABC) transporter HPS44_15185 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HPS44_15190 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HPS44_15195 ENOG4107T8P acyl-Coa dehydrogenase HPS44_15205 ENOG4108UMI ABC transporter, permease HPS44_15210 ENOG4105D01 (LipO)protein HPS44_15215 ENOG4105E2Y ABC, transporter HPS44_15220 ENOG4105X1Q TOBE domain protein HPS44_15225 ENOG4108NST exported protein HPS44_15250 ENOG4108S4H thioesterase Superfamily protein HPS44_15265 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPS44_15270 ENOG4108MG3 formate dehydrogenase HPS44_15275 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HPS44_15285 ENOG4105EM7 Selenocysteine-specific translation elongation factor HPS44_15295 ENOG4105K64 Glycosyl transferase, family 2 HPS44_15300 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPS44_15305 ENOG4108KS2 transglutaminase domain protein HPS44_15310 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HPS44_15320 ENOG4105ETT transcriptional Regulator, LysR family HPS44_15340 ENOG4105C26 Dehydrogenase HPS44_15345 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HPS44_15350 ENOG4105DK0 Indole-3-glycerol phosphate synthase HPS44_15355 ENOG4108I0Q anthranilate phosphoribosyltransferase HPS44_15360 ENOG4105DDQ anthranilate synthase HPS44_15370 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HPS44_15380 ENOG4105NWN ApaG protein HPS44_15390 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HPS44_15395 ENOG4105T95 Thiol disulfide interChange protein HPS44_15405 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HPS44_15415 ENOG4105C3M thioredoxin reductase HPS44_15420 ENOG4105F2Z 3-oxoadipate enol-lactonase HPS44_15435 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_15440 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_15445 ENOG4105C0Z ABC transporter HPS44_15450 ENOG4108IV0 ABC, transporter HPS44_15455 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) HPS44_15470 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HPS44_15480 ENOG4105RE0 Asp Glu hydantoin racemase HPS44_15485 ENOG4106NZI LysR family Transcriptional regulator HPS44_15500 ENOG4107QNJ CoA-transferase subunit B HPS44_15515 ENOG4105E39 Enoyl-CoA hydratase HPS44_15530 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) HPS44_15535 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HPS44_15545 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HPS44_15550 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HPS44_15555 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HPS44_15565 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HPS44_15575 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HPS44_15580 ENOG4105C25 Primosomal protein n' HPS44_15585 ENOG4105C4R Atp-dependent dna helicase HPS44_15590 ENOG4105E7U AraC family transcriptional regulator HPS44_15600 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HPS44_15610 ENOG4105ECQ AraC Family Transcriptional Regulator HPS44_15615 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HPS44_15620 ENOG4105CSR polyphosphate kinase 2 HPS44_15625 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HPS44_15635 ENOG4108JQ7 (ABC) transporter HPS44_15640 ENOG4105C3U ABC transporter HPS44_15655 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_15660 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HPS44_15670 ENOG4105EMY transcriptional regulator HPS44_15675 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_15685 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HPS44_15690 ENOG41060WC Enoyl-CoA hydratase HPS44_15695 ENOG4105E39 Enoyl-CoA hydratase HPS44_15705 ENOG4105KBX Transcriptional regulator, TetR family HPS44_15720 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_15735 ENOG4107XZQ multidrug resistance protein HPS44_15750 ENOG4108ZHJ Organic hydroperoxide resistance protein HPS44_15755 ENOG4105EJC lysr family transcriptional regulator HPS44_15765 ENOG4108KPJ rna polymerase sigma factor HPS44_15770 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HPS44_15775 ENOG4108Z9W Outer membrane porin HPS44_15790 ENOG4105ERH Fumarylacetoacetate hydrolase HPS44_15800 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_15805 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_15810 ENOG4105C2J ABC transporter HPS44_15815 ENOG4108IV0 ABC, transporter HPS44_15825 ENOG4107XBN GntR Family Transcriptional Regulator HPS44_15835 ENOG4105DND Transcriptional regulator HPS44_15845 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HPS44_15855 ENOG4105D9M gamma-glutamylcysteine synthetase HPS44_15885 ENOG4105DG4 malate L-lactate dehydrogenase HPS44_15890 ENOG4108JQ1 Dehydrogenase HPS44_15900 ENOG4105CTX dehydratase HPS44_15905 ENOG4105VP7 SAF domain protein HPS44_15910 ENOG4105FDP GntR family transcriptional regulator HPS44_15915 ENOG4105DWV Homoserine O-trans-acetylase HPS44_15920 ENOG4105DWV Homoserine O-trans-acetylase HPS44_15925 ENOG4105EYM Major Facilitator superfamily HPS44_15935 ENOG4105EN6 Membrane HPS44_15940 ENOG4105DRR Transcriptional regulator, GntR family HPS44_15955 ENOG4105P4J Allophanate hydrolase, subunit 1 HPS44_15965 ENOG4107RSM transcriptional regulator HPS44_15985 ENOG4108S3W Anti-feci sigma factor, fecr HPS44_15995 ENOG4108JQ1 Dehydrogenase HPS44_16010 ENOG4105E3B Multicopper oxidase HPS44_16030 ENOG4105BZU Histidine kinase HPS44_16035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPS44_16040 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HPS44_16055 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HPS44_16065 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HPS44_16070 ENOG4105DFG type I secretion outer membrane protein HPS44_16075 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HPS44_16080 ENOG4105DWF phosphomethylpyrimidine kinase HPS44_16085 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HPS44_16090 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HPS44_16095 ENOG4105D05 Receptor HPS44_16100 ENOG4105C3R Methionine synthase HPS44_16105 ENOG4107YCY Transcriptional regulator HPS44_16120 ENOG4105CPQ Dehydrogenase HPS44_16125 ENOG4105E5Q amino acid AbC transporter HPS44_16130 ENOG4105EAD ABC transporter HPS44_16135 ENOG4105CDA abc transporter atp-binding protein HPS44_16140 ENOG4105CXK mandelate racemase muconate lactonizing HPS44_16145 ENOG4105DEI Mannitol dehydrogenase HPS44_16165 ENOG4105CEN a g-specific adenine glycosylase HPS44_16180 ENOG4105ECQ AraC Family Transcriptional Regulator HPS44_16185 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) HPS44_16190 ENOG4105CRP Part of the ABC transporter FtsEX involved in HPS44_16195 ENOG4105CAK Cell division ATP-binding protein ftsE HPS44_16200 ENOG4107QXX ABC transporter HPS44_16205 ENOG4105EZ7 amino acid ABC transporter HPS44_16210 ENOG4105DRP amino acid AbC transporter HPS44_16215 ENOG4105CDA abc transporter atp-binding protein HPS44_16235 ENOG4108IV0 ABC, transporter HPS44_16240 ENOG4105C2J ABC transporter HPS44_16245 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_16250 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_16260 ENOG4105MSY salicylate hydroxylase HPS44_16265 ENOG4105CBX hi0933 family HPS44_16270 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HPS44_16275 ENOG4105CQC Prephenate dehydratase HPS44_16310 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPS44_16320 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HPS44_16325 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HPS44_16330 ENOG4108Q9V regulatoR HPS44_16345 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HPS44_16350 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HPS44_16355 ENOG4105ENT Efflux transporter rnd family, mfp subunit HPS44_16380 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPS44_16400 ENOG4105EG2 ABC transporter, permease HPS44_16405 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HPS44_16410 ENOG4108IJ9 (ABC) transporter HPS44_16430 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HPS44_16450 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_16455 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_16460 ENOG4105C0Z ABC transporter HPS44_16465 ENOG4108IV0 ABC, transporter HPS44_16485 ENOG4105BZU Histidine kinase HPS44_16490 ENOG4105BZU Histidine kinase HPS44_16510 ENOG4108UKI Enoyl-CoA hydratase HPS44_16550 ENOG4105FUY alpha subunit HPS44_16555 ENOG4108SBK dioxygenase, subunit beta HPS44_16560 ENOG4105D3W isochorismatase HPS44_16565 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HPS44_16575 ENOG4105E4C Lytic transglycosylase catalytic HPS44_16580 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HPS44_16585 ENOG4107RZ7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HPS44_16595 ENOG4105VCQ rubredoxin HPS44_16600 ENOG4108UJU UPF0301 protein HPS44_16605 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HPS44_16615 ENOG4105CD3 dihydroorotase HPS44_16620 ENOG4108Z20 Acyl-transferase HPS44_16635 ENOG4105JSC dimethylmenaquinone methyltransferase HPS44_16645 ENOG4106PMH Extracellular solute-binding protein family 3 HPS44_16650 ENOG4105E5Q amino acid AbC transporter HPS44_16655 ENOG4105DRP amino acid AbC transporter HPS44_16660 ENOG4105CDA abc transporter atp-binding protein HPS44_16670 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HPS44_16680 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HPS44_16685 ENOG4105E2X shikimate dehydrogenase HPS44_16695 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_16700 ENOG4107Z33 ABC transporter, permease HPS44_16710 ENOG4105DHQ Histidine kinase HPS44_16725 ENOG4105IPS esterase HPS44_16730 ENOG4105DFU Cell wall formation (By similarity) HPS44_16735 ENOG4107QX9 Thiol disulfide interChange protein HPS44_16740 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HPS44_16745 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HPS44_16750 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPS44_16755 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HPS44_16765 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HPS44_16790 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HPS44_16810 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPS44_16815 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPS44_16825 ENOG4108YXU transcriptional regulator AsnC family HPS44_16840 ENOG4105DND Transcriptional regulator HPS44_16855 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HPS44_16860 ENOG4105CD5 CoA-binding domain protein HPS44_16865 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HPS44_16870 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HPS44_16890 ENOG4105N42 UPF0307 protein HPS44_16895 ENOG4105CMS peptidase U62, modulator of DNA gyrase HPS44_16900 ENOG4105CH5 extracellular solute-binding protein, family 7 HPS44_16910 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_16915 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_16920 ENOG4105C0Z ABC transporter HPS44_16925 ENOG4108IV0 ABC, transporter HPS44_16930 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HPS44_16935 ENOG4108UJD 30S ribosomal protein S9 HPS44_16940 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HPS44_16950 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HPS44_16965 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HPS44_16975 ENOG4105N14 lysine exporter protein LysE YggA HPS44_16980 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HPS44_16985 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HPS44_16995 ENOG4108RWI nicotinamidase HPS44_17000 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HPS44_17015 ENOG4105CYN Serine protein kinase HPS44_17020 ENOG4106AKX UPF0229 protein HPS44_17025 ENOG4105ED1 spovr family HPS44_17035 ENOG4105ETT transcriptional Regulator, LysR family HPS44_17040 ENOG4105MDS 4-oxalocrotonate tautomerase HPS44_17050 ENOG4108Z33 Thiol disulfide Interchange Protein HPS44_17245 ENOG4105EMN RNA polymerase sigma factor HPS44_17270 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPS44_17275 ENOG4105JGF anti-sigma regulatory factor serine threonine protein kinase HPS44_17280 ENOG41083UI stage II sporulation protein HPS44_17295 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HPS44_17315 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HPS44_17320 ENOG4105E9H Lytic Murein transglycosylase HPS44_17325 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HPS44_17330 ENOG4105D1A Methyltransferase HPS44_17335 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPS44_17345 ENOG4105BZS acriflavin resistance protein HPS44_17350 ENOG4107RZZ dna polymerase iii epsilon subunit HPS44_17365 ENOG4108UPT UPF0178 protein HPS44_17380 ENOG4105D6U Sodium Glutamate Symporter HPS44_17395 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HPS44_17410 ENOG4105CR8 Transcriptional regulator HPS44_17430 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_17440 ENOG4108IV0 ABC, transporter HPS44_17445 ENOG4105C0Z ABC transporter HPS44_17450 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_17460 ENOG4105CMU LysR family (Transcriptional regulator HPS44_17465 ENOG4105VAW lrga family HPS44_17470 ENOG41067MG lrgb family HPS44_17480 ENOG4105T38 integral membrane protein HPS44_17485 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_17500 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HPS44_17510 ENOG4108YXU transcriptional regulator AsnC family HPS44_17525 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HPS44_17530 ENOG4105EHG Permease protein HPS44_17540 ENOG4105KCK Peptidoglycan-associated lipoprotein HPS44_17545 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HPS44_17560 ENOG4105E02 MotA TolQ exbB proton channel HPS44_17565 ENOG4107YD3 Thioesterase HPS44_17570 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HPS44_17600 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HPS44_17605 ENOG4105EXG Transcriptional regulator HPS44_17615 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPS44_17620 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPS44_17660 ENOG4105C01 Dihydroxy-acid dehydratase HPS44_17665 ENOG4105W2Z cytochrome C, class I HPS44_17670 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HPS44_17680 ENOG4105EW9 transcriptional regulator AsnC family HPS44_17720 ENOG4105ETT transcriptional Regulator, LysR family HPS44_17730 ENOG4105CH2 amidohydrolase HPS44_17735 ENOG4105EKE dihydroorotase HPS44_17740 ENOG4105C5H ABC transporter HPS44_17750 ENOG4108V6E Cell division protein mraZ HPS44_17755 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HPS44_17760 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HPS44_17765 ENOG4105CJN penicillin-binding protein HPS44_17770 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HPS44_17775 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HPS44_17780 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HPS44_17790 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HPS44_17795 ENOG4105DFU Cell wall formation (By similarity) HPS44_17800 ENOG4105CPF Cell wall formation (By similarity) HPS44_17805 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HPS44_17810 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HPS44_17815 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HPS44_17820 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HPS44_17830 ENOG4105DR5 peptidase HPS44_17835 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HPS44_17855 ENOG4105C7K acetolactate synthase HPS44_17870 ENOG4108XM1 transcriptional regulator AsnC family HPS44_17885 ENOG4105CJW magnesium transporter HPS44_17890 ENOG4105NAU thioesterase Superfamily protein HPS44_17895 ENOG4105HMI Membrane HPS44_17905 ENOG4105CH2 amidohydrolase HPS44_17910 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_17915 ENOG4105ECY inositol monophosphatase HPS44_17920 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HPS44_17925 ENOG4105CJQ hydrolase, family 31 HPS44_17930 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPS44_17935 ENOG4108UMI ABC transporter, permease HPS44_17940 ENOG4105D01 (LipO)protein HPS44_17965 ENOG4105C42 Type I secretion membrane fusion protein (HlyD HPS44_17995 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_18000 ENOG4106P55 Transcriptional regulator HPS44_18010 ENOG41090R7 Ferric uptake HPS44_18035 ENOG4108R3E Dna-3-methyladenine glycosylase i HPS44_18040 ENOG4105E0M Sulfatase HPS44_18045 ENOG41066T0 asmA family HPS44_18060 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HPS44_18090 ENOG4105KZX Pterin carbinolamine dehydratase HPS44_18115 ENOG4108S0S Nucleotidyl transferase HPS44_18120 ENOG4105EHM Aminoglycoside phosphotransferase HPS44_18130 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HPS44_18135 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HPS44_18140 ENOG4105BZW Glycerate kinase HPS44_18145 ENOG4105CA9 Pyruvate kinase HPS44_18155 ENOG4107QPN acyl-Coa dehydrogenase HPS44_18160 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HPS44_18170 ENOG4107THD Involved in phosphonate degradation (By similarity) HPS44_18180 ENOG4105E9Q Acyl-transferase HPS44_18185 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HPS44_18190 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HPS44_18195 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HPS44_18210 ENOG4107SDU Methyl-accepting chemotaxis HPS44_18220 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_18230 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HPS44_18250 ENOG4105EA8 2-Nitropropane dioxygenase HPS44_18260 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_18265 ENOG4105CHU acetyl-coa acetyltransferase HPS44_18275 ENOG4105CC9 acyl-Coa dehydrogenase HPS44_18280 ENOG4108KC2 acyl-Coa dehydrogenase HPS44_18285 ENOG4108UKI Enoyl-CoA hydratase HPS44_18295 ENOG4108M9J MaoC like domain protein HPS44_18305 ENOG4105CI0 Citrate lyase HPS44_18310 ENOG4108MGF sugar kinase HPS44_18315 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HPS44_18320 ENOG4105DJ0 Poly(A) Polymerase HPS44_18330 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HPS44_18335 ENOG4105CXB phosphoribosylaminoimidazole synthetase HPS44_18345 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HPS44_18350 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HPS44_18355 ENOG4105DQR SNARE associated Golgi HPS44_18365 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HPS44_18370 ENOG4105K8N protein family UPF0079, ATPase HPS44_18375 ENOG4105C9Q fumarate hydratase class II HPS44_18390 ENOG4105DUM transcriptional regulator, lysR family HPS44_18395 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPS44_18400 ENOG4105CUB amino acid HPS44_18405 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_18415 ENOG4105CSU acyl-Coa dehydrogenase HPS44_18420 ENOG4106NZI LysR family Transcriptional regulator HPS44_18425 ENOG4105ERH Fumarylacetoacetate hydrolase HPS44_18455 ENOG4105CR8 Transcriptional regulator HPS44_18465 ENOG4105D5U fad dependent oxidoreductase HPS44_18475 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HPS44_18490 ENOG4105DJY efflux transporter, rnd family, mfp subunit HPS44_18495 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPS44_18500 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_18505 ENOG4106NZI LysR family Transcriptional regulator HPS44_18520 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPS44_18555 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPS44_18560 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPS44_18570 ENOG4105ENT Efflux transporter rnd family, mfp subunit HPS44_18575 ENOG4105CUZ uba thif-type nad fad binding protein HPS44_18610 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPS44_18620 ENOG4108UHU Aldolase HPS44_18635 ENOG4105K64 Glycosyl transferase, family 2 HPS44_18640 ENOG4108IV0 ABC, transporter HPS44_18645 ENOG4105C0Z ABC transporter HPS44_18660 ENOG4105CHR reductase HPS44_18665 ENOG4106IPI cyclase, family HPS44_18680 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_18685 ENOG4108UKV benzoate 1,2-dioxygenase HPS44_18690 ENOG4105FUY alpha subunit HPS44_18715 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_18720 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPS44_18725 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_18730 ENOG4105C3U ABC transporter HPS44_18735 ENOG4108JQ7 (ABC) transporter HPS44_18755 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HPS44_18760 ENOG4105C5H ABC transporter HPS44_18785 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HPS44_18790 ENOG4107QMS site-determining protein HPS44_18795 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HPS44_18800 ENOG4105CX6 glutaminyL-tRNA synthetase HPS44_18810 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPS44_18815 ENOG4105C9U ATP-dependent DNA helicase RecQ HPS44_18835 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HPS44_18845 ENOG4105ECP epimerase HPS44_18850 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HPS44_18855 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HPS44_18870 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPS44_18875 ENOG4105D0A hydroxylase HPS44_18885 ENOG4107RAQ aminopeptidase HPS44_18900 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HPS44_18905 ENOG4108Z9W Outer membrane porin HPS44_18920 ENOG4105ERG peptidase m48, ste24p HPS44_18940 ENOG4105CM2 brancheD-chain amino acid aminotransferase HPS44_18960 ENOG4105EYM Major Facilitator superfamily HPS44_18965 ENOG4107ZSV Receptor HPS44_18975 ENOG4105C1J atp-dependent rna helicase HPS44_18990 ENOG4107TH8 cina domain protein HPS44_18995 ENOG41069M3 Transcriptional regulator HPS44_19010 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HPS44_19015 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate HPS44_19020 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HPS44_19110 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HPS44_19115 ENOG41090R7 Ferric uptake HPS44_19120 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HPS44_19130 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HPS44_19135 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HPS44_19145 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HPS44_19155 ENOG4105CFG Acts as a chaperone (By similarity) HPS44_19160 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HPS44_19175 ENOG4108YYQ gCN5-related N-acetyltransferase HPS44_19195 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPS44_19230 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_19235 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_19250 ENOG4105EEX Two component transcriptional regulator (Winged helix family HPS44_19255 ENOG4105C08 Histidine kinase HPS44_19260 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HPS44_19265 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HPS44_19270 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HPS44_19285 ENOG4107QN1 sodium solute HPS44_19295 ENOG4105C98 muts2 protein HPS44_19300 ENOG4105C3M thioredoxin reductase HPS44_19305 ENOG4105CNU cell division protein FtsK HPS44_19310 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HPS44_19315 ENOG4105KME endoribonuclease L-psp HPS44_19325 ENOG4105C2X Arabinose 5-phosphate isomerase HPS44_19365 ENOG4105D1H recombination factor protein RarA HPS44_19370 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HPS44_19410 ENOG4105DIA mandelate racemase muconate lactonizing HPS44_19415 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_19435 ENOG4108IPW abc transporter atp-binding protein HPS44_19475 ENOG4105DTD Dehydrogenase HPS44_19480 ENOG4105D1Q UPF0246 protein HPS44_19490 ENOG4105C7K acetolactate synthase HPS44_19495 ENOG4108ZP8 Acetolactate synthase small subunit HPS44_19500 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HPS44_19505 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HPS44_19515 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HPS44_19520 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HPS44_19530 ENOG4105C7B Threonine dehydratase HPS44_19540 ENOG4105ES4 Nitrilase HPS44_19550 ENOG4105E7U AraC family transcriptional regulator HPS44_19575 ENOG4105CP7 Triose-phosphate isomerase HPS44_19580 ENOG4105NTZ Preprotein translocase subunit SecG HPS44_19620 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_19640 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HPS44_19660 ENOG4108SF5 RNA Polymerase HPS44_19665 ENOG4108S3W Anti-feci sigma factor, fecr HPS44_19680 ENOG4108SF5 RNA Polymerase HPS44_19700 ENOG4105ECM Sensor protein basS pmrB HPS44_19710 ENOG4105D4T Citrate transporter HPS44_19715 ENOG4105CHR reductase HPS44_19735 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPS44_19740 ENOG4105CQZ Histidine kinase HPS44_19760 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HPS44_19765 ENOG4105XDF Protein of unknown function (DUF1272) HPS44_19770 ENOG4105CKW Inner membrane protein yedI HPS44_19775 ENOG4105GAV receptor HPS44_19800 ENOG4108JQ6 ABC transporter HPS44_19810 ENOG4106R87 Extracellular solute-binding protein, family 5 HPS44_19830 ENOG4105BZS acriflavin resistance protein HPS44_19845 ENOG4105C94 Transporter HPS44_19850 ENOG4105ENT Efflux transporter rnd family, mfp subunit HPS44_19855 ENOG4105BZS acriflavin resistance protein HPS44_19870 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_19875 ENOG4105BZS acriflavin resistance protein HPS44_19880 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPS44_19885 ENOG4108IG5 Transcriptional regulator HPS44_19890 ENOG4108R4R Iron-regulated virulence regulatory protein HPS44_19910 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HPS44_19935 ENOG4108Z9W Outer membrane porin HPS44_19940 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HPS44_19945 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPS44_19950 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HPS44_19955 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPS44_19970 ENOG4108IEH NADH dehydrogenase subunit g HPS44_19975 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HPS44_19980 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPS44_19985 ENOG4105DF2 NADH dehydrogenase subunit j HPS44_19990 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPS44_20000 ENOG4105C8S subunit m HPS44_20005 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPS44_20015 ENOG4108ESX Receptor HPS44_20020 ENOG4105EAC phosphoserine phosphatase HPS44_20025 ENOG4108JA2 transcriptioN-repair coupling factor HPS44_20030 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HPS44_20035 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HPS44_20045 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPS44_20050 ENOG4105D3R alkyl hydroperoxide reductase HPS44_20055 ENOG4105E0F Histidine kinase HPS44_20065 ENOG41072GX Peptidase M22 Glycoprotease HPS44_20070 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HPS44_20075 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) HPS44_20080 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HPS44_20090 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HPS44_20095 ENOG4107TF3 peptidylprolyl cis-trans isomerase HPS44_20105 ENOG4107835 probably involved in intracellular septation (By similarity) HPS44_20110 ENOG4105E0X reductase HPS44_20115 ENOG4108JJB ABC transporter HPS44_20120 ENOG4107QCX Transporter HPS44_20125 ENOG4107ZYJ bioY protein HPS44_20140 ENOG4105C0Z ABC transporter HPS44_20145 ENOG4108IV0 ABC, transporter HPS44_20155 ENOG4105HSS phospholipase C HPS44_20175 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_20185 ENOG4108IV0 ABC, transporter HPS44_20190 ENOG4105C0Z ABC transporter HPS44_20195 ENOG4105CSM endonuclease III HPS44_20200 ENOG4108R3D Electron transport complex HPS44_20210 ENOG4105DP0 ferredoxin-NADP reductase HPS44_20215 ENOG4108Z4U Ferredoxin HPS44_20220 ENOG4107RH7 Nicotinate phosphoribosyltransferase HPS44_20225 ENOG4105M4H endoribonuclease L-psp HPS44_20235 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HPS44_20240 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPS44_20245 ENOG4105CSH Transporter HPS44_20250 ENOG4105CWC Acetylornithine deacetylase HPS44_20260 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HPS44_20265 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HPS44_20270 ENOG41061N2 exported protein HPS44_20275 ENOG4107QQB Ribonuclease E HPS44_20280 ENOG4105EI2 Pseudouridine synthase HPS44_20285 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HPS44_20290 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HPS44_20295 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HPS44_20305 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HPS44_20310 ENOG4108UHJ MAF-like protein HPS44_20315 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HPS44_20320 ENOG4105VGS 50s ribosomal protein l32 HPS44_20330 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPS44_20335 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HPS44_20340 ENOG4105CHR reductase HPS44_20345 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HPS44_20350 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPS44_20360 ENOG4105EMN RNA polymerase sigma factor HPS44_20375 ENOG4105C0H protease HPS44_20380 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HPS44_20385 ENOG4105C3F Signal peptidase i HPS44_20390 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HPS44_20395 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HPS44_20400 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HPS44_20450 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HPS44_20460 ENOG4108MP6 LysR family Transcriptional regulator HPS44_20470 ENOG4105C26 Dehydrogenase HPS44_20475 ENOG4107R11 Transcriptional regulator HPS44_20485 ENOG4105K4H Nlp p60 protein HPS44_20490 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPS44_20495 ENOG4108ZJF Glcg protein HPS44_20510 ENOG4108Q5Y Membrane HPS44_20515 ENOG4105C5W Aldolase HPS44_20520 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPS44_20545 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HPS44_20565 ENOG4107YB6 acetyltransferase, (GNAT) family HPS44_20575 ENOG4105D44 asparaginase HPS44_20580 ENOG4108JQ6 ABC transporter HPS44_20585 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_20620 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HPS44_20630 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HPS44_20645 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HPS44_20655 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPS44_20685 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HPS44_20690 ENOG4108YXA Membrane HPS44_20695 ENOG4105DXD 2-methylcitrate dehydratase HPS44_20700 ENOG4105BZN citrate synthase HPS44_20705 ENOG4105CR4 methylisocitrate lyase HPS44_20710 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HPS44_20715 ENOG4105FDP GntR family transcriptional regulator HPS44_20720 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HPS44_20725 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HPS44_20735 ENOG4105E33 succinate dehydrogenase HPS44_20740 ENOG41060IS Flavinator of succinate dehydrogenase HPS44_20745 ENOG4105BZN citrate synthase HPS44_20760 ENOG4105C6K Malic enzyme HPS44_20765 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HPS44_20770 ENOG4105EPD Oligopeptide transporter, Opt family HPS44_20775 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HPS44_20790 ENOG4105K6H D-cysteine desulfhydrase HPS44_20795 ENOG4108XM1 transcriptional regulator AsnC family HPS44_20800 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HPS44_20805 ENOG4105C7S Dehydrogenase HPS44_20810 ENOG4107QN2 dihydrolipoyl dehydrogenase HPS44_20815 ENOG4105D6Z AFG1 family ATPase HPS44_20820 ENOG4108SF5 RNA Polymerase HPS44_20825 ENOG4108S3W Anti-feci sigma factor, fecr HPS44_20830 ENOG4105E0K tonB-dependent siderophore receptor HPS44_20865 ENOG4105BZM domain protein HPS44_20870 ENOG4105DVT helicase HPS44_20875 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HPS44_20880 ENOG4105C34 Pseudouridine synthase HPS44_20885 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HPS44_20890 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class HPS44_20895 ENOG4105CHR reductase HPS44_20900 ENOG4108NVM synthesis repressor PhaR HPS44_20925 ENOG4105D5K Hemolysin activator protein HPS44_20950 ENOG4105JAB phenazine biosynthesis protein, phzf family HPS44_20955 ENOG4105K3G Periplasmic Protein HPS44_20965 ENOG4105VDW Csbd family HPS44_20980 ENOG4105BZ1 (ABC) transporter HPS44_20995 ENOG4105ED9 Protein of unknown function (DUF455) HPS44_21000 ENOG4108RPX mosc domain containing protein HPS44_21005 ENOG4105CVE Lytic murein transglycosylase HPS44_21020 ENOG4105C1G acyl-Coa dehydrogenase HPS44_21030 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HPS44_21040 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HPS44_21050 ENOG4108XTA Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate HPS44_21060 ENOG410802X bacteriophage n4 adsorption protein b HPS44_21070 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPS44_21085 ENOG4105F27 Major Facilitator HPS44_21090 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HPS44_21095 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HPS44_21100 ENOG4105UYK outer membrane protein a HPS44_21105 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPS44_21110 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HPS44_21115 ENOG4105CQC Prephenate dehydratase HPS44_21120 ENOG4105CIH Imidazole acetol-phosphate transaminase HPS44_21130 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HPS44_21135 ENOG4105CAT Cytidine monophosphate kinase HPS44_21140 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HPS44_21155 ENOG4105CFV Tetratricopeptide repeat protein HPS44_21160 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HPS44_21165 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HPS44_21175 ENOG4105C6T cysteine synthase HPS44_21195 ENOG4105CVE Lytic murein transglycosylase HPS44_21205 ENOG4105BZJ Electron transfer flavoprotein HPS44_21210 ENOG4105C10 Electron transfer flavoprotein HPS44_21230 ENOG4105CSU acyl-Coa dehydrogenase HPS44_21235 ENOG4105D3R alkyl hydroperoxide reductase HPS44_21240 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HPS44_21245 ENOG4108I5D sulfate abc transporter HPS44_21270 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HPS44_21290 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HPS44_21295 ENOG4105P8F nudix hydrolase HPS44_21300 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HPS44_21305 ENOG4105D0M Protease HtpX homolog HPS44_21310 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HPS44_21320 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HPS44_21325 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HPS44_21330 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HPS44_21335 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HPS44_21340 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HPS44_21345 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HPS44_21350 ENOG4105C26 Dehydrogenase HPS44_21355 ENOG4108UKI Enoyl-CoA hydratase HPS44_21360 ENOG4108ZJI phenylacetic acid degradation protein HPS44_21370 ENOG4107QI1 Mate efflux family protein HPS44_21385 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HPS44_21390 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) HPS44_21395 ENOG4105W5Q DNA repair protein (RadC HPS44_21405 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HPS44_21410 ENOG4108RXX maleylacetoacetate isomerase HPS44_21415 ENOG4105C0H protease HPS44_21420 ENOG4105DHQ Histidine kinase HPS44_21425 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_21440 ENOG4105CKI cobalamin synthesis protein HPS44_21445 ENOG4105CKI cobalamin synthesis protein HPS44_21450 ENOG4105EJC lysr family transcriptional regulator HPS44_21465 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HPS44_21470 ENOG4105FE9 pseudouridine synthase HPS44_21475 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HPS44_21480 ENOG4105CHV Transcription elongation factor NusA HPS44_21485 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HPS44_21490 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HPS44_21495 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HPS44_21500 ENOG4105CI3 gtp-binding protein typa HPS44_21525 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HPS44_21530 ENOG4108URH decarboxylase HPS44_21535 ENOG4105C2M dna polymerase I HPS44_21545 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HPS44_21550 ENOG4105EAM Na Pi-cotransporter HPS44_21555 ENOG4105EJQ L-serine dehydratase HPS44_21560 ENOG4105D0M Protease HtpX homolog HPS44_21570 ENOG4105KHC sulfurtransferase HPS44_21580 ENOG4105DUM transcriptional regulator, lysR family HPS44_21585 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_21595 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HPS44_21630 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HPS44_21635 ENOG4105CTB Polyprenyl synthetase HPS44_21645 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) HPS44_21650 ENOG4105NX3 Membrane HPS44_21655 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HPS44_21665 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HPS44_21670 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HPS44_21680 ENOG4105CDU Replicative dna helicase HPS44_21685 ENOG4105DHU Bile acid HPS44_21690 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HPS44_21700 ENOG4105EW9 transcriptional regulator AsnC family HPS44_21725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_21775 ENOG4105CXT aspartate transcarbamylase HPS44_21795 ENOG4105CSH Transporter HPS44_21800 ENOG4105DHQ Histidine kinase HPS44_21810 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HPS44_21815 ENOG4108004 Modulates RecA activity (By similarity) HPS44_21820 ENOG4105DZ2 Transcriptional regulator HPS44_21840 ENOG4105CMV Succinyl-CoA synthetase subunit beta HPS44_21845 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HPS44_21850 ENOG4108ZCF integral membrane protein HPS44_21855 ENOG4108ZCF integral membrane protein HPS44_21860 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HPS44_21880 ENOG4105F0N pyrophosphate phospho-hydrolase HPS44_21910 ENOG4105C0Z ABC transporter HPS44_21915 ENOG4108IV0 ABC, transporter HPS44_21920 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_21940 ENOG4108IAB Phoh family HPS44_21945 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPS44_21955 ENOG4105CHM Aminotransferase HPS44_21960 ENOG4105D6E homoserine dehydrogenase HPS44_21975 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HPS44_21980 ENOG4105CD8 aminopeptidase N HPS44_21990 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HPS44_21995 ENOG4105D1U peptidase U62 modulator of DNA gyrase HPS44_22000 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPS44_22005 ENOG4105CQB FAD linked oxidase domain protein HPS44_22010 ENOG4105CQB FAD linked oxidase domain protein HPS44_22015 ENOG4105EU8 FAD linked oxidase domain protein HPS44_22020 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPS44_22025 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HPS44_22030 ENOG4105W8H transhydrogenase (subunit alpha HPS44_22035 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HPS44_22050 ENOG4105ETT transcriptional Regulator, LysR family HPS44_22055 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HPS44_22060 ENOG4105HF0 Membrane HPS44_22065 ENOG4108U78 Glutathione S-transferase HPS44_22070 ENOG4107QTF adenylosuccinate lyase HPS44_22075 ENOG4105T86 cytochrome C HPS44_22105 ENOG4108REF Sporulation integral membrane protein ytvi HPS44_22115 ENOG4108MAJ Membrane HPS44_22195 ENOG4105UZW Tail fiber assembly protein HPS44_22215 ENOG4105BZU Histidine kinase HPS44_22225 ENOG4105RPH Inner membrane protein YddG HPS44_22260 ENOG41067HS methyltransferase HPS44_22270 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HPS44_22275 ENOG4105CBC glutamate synthase HPS44_22285 ENOG41066VF YeeE YedE family protein HPS44_22290 ENOG4105RK9 auxin efflux carrier HPS44_22300 ENOG4108HPG -acetyltransferase HPS44_22320 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HPS44_22325 ENOG4105C2N RNA methyltransferase TrmH family group 3 HPS44_22330 ENOG4105C28 cystathionine HPS44_22335 ENOG4107E2E PKHD-type hydroxylase HPS44_22340 ENOG4105K70 DNA-binding protein HPS44_22365 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_22370 ENOG4105DHQ Histidine kinase HPS44_22375 ENOG4105DFH Transport of potassium into the cell (By similarity) HPS44_22385 ENOG4105CDH Citrulline--aspartate ligase HPS44_22390 ENOG4105C5Q Transcriptional regulator HPS44_22395 ENOG4105GAK amidohydrolase 2 HPS44_22415 ENOG4108XEP Alpha Beta Hydrolase Fold protein HPS44_22420 ENOG4105DBV ornithine carbamoyltransferase HPS44_22425 ENOG4105C8Y Acetylornithine aminotransferase HPS44_22435 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_22445 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPS44_22450 ENOG4105CV6 ABC transporter, permease HPS44_22460 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) HPS44_22470 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_22475 ENOG4105F38 ABC transporter, permease HPS44_22480 ENOG4105D38 putrescine abc transporter HPS44_22490 ENOG4108RB4 3-methyladenine DNA glycosylase HPS44_22500 ENOG4107QSV RmuC domain protein HPS44_22510 ENOG4105CSU acyl-Coa dehydrogenase HPS44_22520 ENOG4108UTW Plays a role in the regulation of phosphate uptake HPS44_22525 ENOG4105HSS phospholipase C HPS44_22530 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HPS44_22535 ENOG4108EKC n-acetylglutamate synthase HPS44_22540 ENOG4105CQ7 ATP-dependent helicase HPS44_22545 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HPS44_22560 ENOG4105C0B DNA polymerase III (alpha subunit) HPS44_22565 ENOG4105CPK Glycosyl transferase (Group 1 HPS44_22570 ENOG4107BJW polysaccharide deacetylase HPS44_22575 ENOG4106WTF Glycosyl transferase, family 2 HPS44_22580 ENOG4107T8Q Glycosyl transferase (Group 1 HPS44_22585 ENOG4107BJW polysaccharide deacetylase HPS44_22595 ENOG4105KRS Proteinase inhibitor HPS44_22610 ENOG4105BZ1 (ABC) transporter HPS44_22615 ENOG4105CKD glutathione-regulated potassium-efflux system protein HPS44_22630 ENOG4106JH6 (LipO)protein HPS44_22635 ENOG4105C03 ribonuclease HPS44_22665 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_22675 ENOG4105CK2 sodium dicarboxylate symporter HPS44_22685 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HPS44_22690 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HPS44_22695 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HPS44_22705 ENOG4105C12 Phosphoribosylglycinamide synthetase HPS44_22710 ENOG4105CDY transcriptional regulatory protein HPS44_22715 ENOG4105D7A ATP-binding protein HPS44_22720 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HPS44_22730 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPS44_22735 ENOG4105CW7 secretion protein, HlyD family HPS44_22740 ENOG4105ETP RND efflux system, outer membrane lipoprotein HPS44_22745 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HPS44_22760 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HPS44_22805 ENOG4105WPN DNA integration recombination invertion protein HPS44_22810 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HPS44_22820 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HPS44_22825 ENOG4105K63 Thioredoxin HPS44_22830 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPS44_22840 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPS44_22845 ENOG4107Z3H Transcriptional regulator, TetR family HPS44_22855 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPS44_22880 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HPS44_22885 ENOG4105EV8 ectoine hydroxylase HPS44_22890 ENOG4105QVC MOSC domain-containing protein HPS44_22895 ENOG4105KPY Small multidrug resistance protein HPS44_22910 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPS44_22925 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPS44_22930 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HPS44_22940 ENOG4105K5M 30s ribosomal protein S16 HPS44_22950 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HPS44_22955 ENOG4105WBV Transcriptional regulator HPS44_22960 ENOG4106TNF Periplasmic binding protein HPS44_22965 ENOG4105E5Q amino acid AbC transporter HPS44_22970 ENOG4105CDA abc transporter atp-binding protein HPS44_22975 ENOG4105CJP fad dependent oxidoreductase HPS44_22980 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HPS44_22985 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HPS44_22990 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HPS44_23010 ENOG4105N21 Membrane HPS44_23015 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HPS44_23020 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HPS44_23025 ENOG4105CIH Imidazole acetol-phosphate transaminase HPS44_23030 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HPS44_23035 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HPS44_23040 ENOG4107QJR hflk protein HPS44_23045 ENOG4105EPW hflc protein HPS44_23050 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HPS44_23055 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HPS44_23060 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HPS44_23065 ENOG4105VCC 30S ribosomal protein S21 HPS44_23075 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPS44_23085 ENOG4105CPK Glycosyl transferase (Group 1 HPS44_23155 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPS44_23165 ENOG4107S2Z UPF0761 membrane protein HPS44_23175 ENOG4105CNG UPF0061 protein HPS44_23195 ENOG4105BZU Histidine kinase HPS44_23200 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HPS44_23205 ENOG4105ERG peptidase m48, ste24p HPS44_23295 ENOG4108JJA ABC, transporter HPS44_23305 ENOG4105DFG type I secretion outer membrane protein HPS44_23325 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPS44_23335 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HPS44_23340 ENOG4105CH5 extracellular solute-binding protein, family 7 HPS44_23365 ENOG4105CPT Alpha beta hydrolase HPS44_23400 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPS44_23405 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_23410 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HPS44_23415 ENOG4105DIQ Transcriptional regulator HPS44_23420 ENOG4105FR1 rard protein HPS44_23430 ENOG4105K8K Cupin 2, conserved barrel HPS44_23435 ENOG4108JQ6 ABC transporter HPS44_23440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_23445 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPS44_23455 ENOG4105C26 Dehydrogenase HPS44_23460 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HPS44_23485 ENOG4105D4P Coproporphyrinogen iii oxidase HPS44_23490 ENOG41068CG regulatoR HPS44_23495 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HPS44_23500 ENOG4105C22 threonyL-tRNA synthetase HPS44_23505 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HPS44_23520 ENOG41080Z8 PHOSPHOCARRIER protein HPS44_23525 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPS44_23530 ENOG4105BZU Histidine kinase HPS44_23535 ENOG4108YZA Nitrogen regulatory protein pii HPS44_23545 ENOG4105W0Z cytoplasmic protein HPS44_23550 ENOG4105C0P Mg chelatase subunit ChlI HPS44_23555 ENOG4105VJV 50s ribosomal protein L35 HPS44_23560 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HPS44_23565 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HPS44_23570 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HPS44_23630 ENOG4108R6G acetyltransferase HPS44_23665 ENOG4108YXU transcriptional regulator AsnC family HPS44_23725 ENOG4105E2Y ABC, transporter HPS44_23740 ENOG4105C5Q Transcriptional regulator HPS44_23745 ENOG4105DHU Bile acid HPS44_23755 ENOG4108JJ7 ABC transporter HPS44_23760 ENOG4105CV8 reductase HPS44_23775 ENOG4108R1E Serine threonine protein phosphatase 1 HPS44_23780 ENOG4108JQC penicillin-binding protein 1A HPS44_23785 ENOG4105ID8 Transcriptional regulator, ARAC family HPS44_23790 ENOG4105EU0 Major facilitator Superfamily HPS44_23800 ENOG4105CND Glycosyl transferase, family 2 HPS44_23805 ENOG4107BJW polysaccharide deacetylase HPS44_23810 ENOG4108TUY outer membrane protein PgaA HPS44_23815 ENOG4105BZU Histidine kinase HPS44_23835 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HPS44_23840 ENOG4105KTH gatB Yqey HPS44_23850 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPS44_23855 ENOG4105C2D reductase HPS44_23865 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPS44_23905 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HPS44_23920 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HPS44_23945 ENOG4105KPV Transcriptional regulator HPS44_23950 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPS44_23955 ENOG4105SX7 Transporter HPS44_23960 ENOG41062BK proline dehydrogenase HPS44_23985 ENOG4107RDB Major Facilitator HPS44_23995 ENOG4105EXG Transcriptional regulator HPS44_24020 ENOG4108IY8 ABC, transporter HPS44_24035 ENOG4105CSU acyl-Coa dehydrogenase HPS44_24040 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_24060 ENOG4105DSQ Nitric oxide reductase HPS44_24065 ENOG4105E6M Sulphatase-modifying factor protein HPS44_24080 ENOG4108W3Y Transcriptional regulator, Crp Fnr family HPS44_24090 ENOG4105MPD Cytochrome HPS44_24095 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HPS44_24100 ENOG4105DC8 reductase HPS44_24110 ENOG4105N14 lysine exporter protein LysE YggA HPS44_24125 ENOG4108Q5Y Membrane HPS44_24145 ENOG4107QI1 Mate efflux family protein HPS44_24150 ENOG4108IPT Naphthoate synthase HPS44_24155 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HPS44_24165 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPS44_24170 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HPS44_24180 ENOG4105CHR reductase HPS44_24215 ENOG4108K3Z AraC family transcriptional regulator HPS44_24230 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HPS44_24240 ENOG4108JQ1 Dehydrogenase HPS44_24245 ENOG4105JSC dimethylmenaquinone methyltransferase HPS44_24255 ENOG4105DMF Dehydrogenase HPS44_24280 ENOG4105EUB pirin domain protein HPS44_24295 ENOG4105KWW Biogenesis protein HPS44_24300 ENOG4107QX9 Thiol disulfide interChange protein HPS44_24305 ENOG4105DA4 cytochrome c-type biogenesis protein HPS44_24310 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HPS44_24320 ENOG41060IM Heme exporter protein HPS44_24325 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HPS44_24330 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HPS44_24345 ENOG4108J2R molybdopterin oxidoreductase HPS44_24350 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) HPS44_24355 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPS44_24360 ENOG4106WHD Tetrathionate reductase HPS44_24365 ENOG4105DB1 molybdopterin oxidoreductase HPS44_24370 ENOG4108M1T Cytochrome c-type biogenesis protein HPS44_24375 ENOG4105KWW Biogenesis protein HPS44_24380 ENOG4107QX9 Thiol disulfide interChange protein HPS44_24385 ENOG4105DA4 cytochrome c-type biogenesis protein HPS44_24400 ENOG41060IM Heme exporter protein HPS44_24405 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HPS44_24410 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HPS44_24425 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HPS44_24445 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_24450 ENOG4107RSM transcriptional regulator HPS44_24460 ENOG4105C01 Dihydroxy-acid dehydratase HPS44_24470 ENOG4105BZU Histidine kinase HPS44_24475 ENOG4105E39 Enoyl-CoA hydratase HPS44_24520 ENOG4107S01 Repressor protein MetJ HPS44_24530 ENOG4105CBN LysR family transcriptional regulator HPS44_24535 ENOG4105CY2 Citrate transporter HPS44_24540 ENOG4105CNM Receptor HPS44_24555 ENOG4105E09 nadh pyrophosphatase HPS44_24575 ENOG4108S8N class II Aldolase HPS44_24580 ENOG4105CSH Transporter HPS44_24600 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_24615 ENOG4105CHR reductase HPS44_24635 ENOG4105EW9 transcriptional regulator AsnC family HPS44_24640 ENOG4105CCF Lysine exporter protein (Lyse ygga) HPS44_24645 ENOG4108JJ7 ABC transporter HPS44_24650 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_24655 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPS44_24670 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_24675 ENOG4105CHR reductase HPS44_24710 ENOG4105ETT transcriptional Regulator, LysR family HPS44_24720 ENOG4105F04 LysR family Transcriptional regulator HPS44_24730 ENOG4105EJC lysr family transcriptional regulator HPS44_24740 ENOG4107RTG Major Facilitator superfamily HPS44_24745 ENOG4108IG5 Transcriptional regulator HPS44_24755 ENOG4105ETE Transcriptional regulator (LacI family HPS44_24760 ENOG4108SC4 )-transporter HPS44_24765 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPS44_24815 ENOG4105EA8 2-Nitropropane dioxygenase HPS44_24850 ENOG4105VUH addiction module killer protein HPS44_24870 ENOG4105C26 Dehydrogenase HPS44_24875 ENOG4108R6K riboflavin synthase, subunit alpha HPS44_24885 ENOG4105CSP Major Facilitator Superfamily HPS44_24895 ENOG4108MK9 spermidine N(1)-acetyltransferase HPS44_24905 ENOG4105W1Y Transcriptional regulator HPS44_24930 ENOG4105E0K tonB-dependent siderophore receptor HPS44_24935 ENOG4107R0V Pyruvate dehydrogenase HPS44_24940 ENOG4105CPP Dehydrogenase, E1 component HPS44_24945 ENOG4107QSN dihydrolipoamide acetyltransferase HPS44_24950 ENOG4107QN2 dihydrolipoyl dehydrogenase HPS44_24960 ENOG41063XI Toxic component of a toxin-antitoxin (TA) module. A HPS44_24965 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HPS44_24970 ENOG4105CH7 arginosuccinase HPS44_24975 ENOG4105CUY Mechanosensitive ion channel HPS44_24985 ENOG4108YZA Nitrogen regulatory protein pii HPS44_24990 ENOG4105D7Q type ii secretion system HPS44_24995 ENOG4105GVR general secretion pathway protein D HPS44_25000 ENOG4107QHF type ii secretion system protein e HPS44_25030 ENOG4108RTD type II secretion system protein K HPS44_25035 ENOG4108WWZ General secretion pathway protein J HPS44_25040 ENOG4105X5Z General secretion pathway protein I HPS44_25045 ENOG41069X0 general secretion pathway protein h HPS44_25050 ENOG4108VAU general secretion pathway protein G HPS44_25070 ENOG4105HSS phospholipase C HPS44_25075 ENOG4105DUM transcriptional regulator, lysR family HPS44_25080 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPS44_25085 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_25090 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPS44_25095 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_25100 ENOG4108JQ6 ABC transporter HPS44_25105 ENOG4108VWS Yaeq family HPS44_25120 ENOG4105C57 major facilitator superfamily HPS44_25125 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HPS44_25130 ENOG4105FE9 pseudouridine synthase HPS44_25135 ENOG4105CR8 Transcriptional regulator HPS44_25140 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPS44_25145 ENOG4105BZS acriflavin resistance protein HPS44_25150 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_25170 ENOG4105DGW oligopeptidase A HPS44_25175 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HPS44_25180 ENOG4108ZXC Two component transcriptional regulator, luxr family HPS44_25185 ENOG4105BZU Histidine kinase HPS44_25190 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HPS44_25195 ENOG4107QSN dihydrolipoamide acetyltransferase HPS44_25200 ENOG4107QN2 dihydrolipoyl dehydrogenase HPS44_25210 ENOG4105CBN LysR family transcriptional regulator HPS44_25260 ENOG4105FAW cDP-glucose 4,6-dehydratase HPS44_25270 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HPS44_25280 ENOG4105I03 Flagellin HPS44_25285 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPS44_25290 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HPS44_25295 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HPS44_25300 ENOG4107RD7 Flagellar Motor Protein, MotA HPS44_25305 ENOG4105ER2 Ompa motb domain protein HPS44_25310 ENOG4108VYJ response regulator receiver protein HPS44_25315 ENOG4105CBS Chea signal transduction histidine kinase HPS44_25320 ENOG4108V3W Chemotaxis protein, CheW HPS44_25325 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_25330 ENOG4105BZU Histidine kinase HPS44_25335 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HPS44_25340 ENOG4108VYJ response regulator receiver protein HPS44_25345 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HPS44_25350 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_25355 ENOG4105D00 flagellar biosynthetic protein flhB HPS44_25360 ENOG4105D7B Flagellar biosynthesis protein flha HPS44_25365 ENOG4105FZW flagellar biosynthesis regulator FlhF HPS44_25375 ENOG4105M9M anti-sigma28 factor FlgM HPS44_25385 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HPS44_25390 ENOG4108ZC9 flagellar basal-body rod protein flgc HPS44_25395 ENOG4105W00 Flagellar hook capping protein HPS44_25400 ENOG4105BZE flagellar hook protein, FlgE HPS44_25405 ENOG4108KPB Flagellar basal-body rod protein FlgF HPS44_25410 ENOG4105CGA flagellar basal-body rod protein FlgG HPS44_25425 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HPS44_25430 ENOG4105E1Q flagellar hook-associated protein HPS44_25435 ENOG4105DTJ flagellar hook-associated protein HPS44_25440 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_25445 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_25455 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_25460 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HPS44_25465 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HPS44_25470 ENOG4105VS8 Flagellar biosynthetic protein fliq HPS44_25475 ENOG4105CN7 Flagellar biosynthetic protein FliP HPS44_25480 ENOG4105K0P flagellar biosynthesis protein HPS44_25485 ENOG4105DD5 Flagellar motor switch protein HPS44_25490 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPS44_25495 ENOG4107ZI8 flagellar basal body-associated protein flil HPS44_25510 ENOG4108JIR Flagellum-specific ATP synthase HPS44_25520 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPS44_25525 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HPS44_25530 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HPS44_25540 ENOG4105D00 flagellar biosynthetic protein flhB HPS44_25555 ENOG4105MQ3 flagellar protein FliS HPS44_25560 ENOG4105DTS flagellar hook-associated HPS44_25565 ENOG41063QE flagellar protein FlaG HPS44_25570 ENOG4106P37 HTH-type transcriptional regulator YjhI HPS44_25580 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_25595 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HPS44_25610 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HPS44_25615 ENOG4108VKG metal-dependent hydrolase HPS44_25620 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HPS44_25630 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HPS44_25635 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPS44_25645 ENOG4105CE9 30S ribosomal protein S2 HPS44_25650 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HPS44_25655 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HPS44_25660 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HPS44_25665 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HPS44_25670 ENOG4105KNE Phosphatidate cytidylyltransferase HPS44_25680 ENOG4105DZP Membrane-associated zinc metalloprotease HPS44_25685 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HPS44_25690 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HPS44_25695 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HPS44_25700 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HPS44_25715 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPS44_25750 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HPS44_25755 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPS44_25760 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPS44_25780 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HPS44_25785 ENOG4108Z1B Cyclase dehydrase HPS44_25800 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_25805 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPS44_25820 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HPS44_25825 ENOG4105HHA aminodeoxychorismate lyase HPS44_25830 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HPS44_25835 ENOG4105C6E dna polymerase iii HPS44_25840 ENOG4105F8V Hydrolase, tatD family HPS44_25855 ENOG4106TNF Periplasmic binding protein HPS44_25860 ENOG4105E5Q amino acid AbC transporter HPS44_25865 ENOG4105CDA abc transporter atp-binding protein HPS44_25870 ENOG41088SP formiminoglutamate hydrolase HPS44_25880 ENOG4105D82 Glutamate dehydrogenase HPS44_25890 ENOG4105DF9 Lipoate-protein, ligase HPS44_25905 ENOG4105CYM Glutathione S-transferase HPS44_25915 ENOG4108YXU transcriptional regulator AsnC family HPS44_25920 ENOG4108V06 Glutathione peroxidase HPS44_25925 ENOG4105F27 Major Facilitator HPS44_25930 ENOG4105WAP TPR repeat-containing protein HPS44_25940 ENOG4107S2N Type III effector Hrp-dependent HPS44_25945 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HPS44_25955 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HPS44_25960 ENOG4105CVP deoxyribo-dipyrimidine photolyase HPS44_25965 ENOG410846T CoA-transferase family III HPS44_25990 ENOG4108YZN class I peptide chain release factor HPS44_26000 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPS44_26030 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HPS44_26045 ENOG4107QWP ABC-2 type transporter HPS44_26050 ENOG4105CJ1 ABC, transporter HPS44_26060 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HPS44_26070 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HPS44_26080 ENOG4105E98 transcriptional regulator DeoR family HPS44_26085 ENOG4108IJ9 (ABC) transporter HPS44_26090 ENOG4108IJ9 (ABC) transporter HPS44_26140 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HPS44_26145 ENOG4108Z9W Outer membrane porin HPS44_26165 ENOG4108JU3 Alkyl hydroperoxide reductase HPS44_26170 ENOG41062ES Transcriptional regulator HPS44_26180 ENOG4105CBN LysR family transcriptional regulator HPS44_26185 ENOG4105C1G acyl-Coa dehydrogenase HPS44_26215 ENOG4105EW9 transcriptional regulator AsnC family HPS44_26220 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPS44_26225 ENOG4107RH8 nuclease SbcCD subunit D HPS44_26255 ENOG4105D65 subunit l HPS44_26260 ENOG4108ZE9 Monovalent cation H antiporter subunit C HPS44_26265 ENOG4107R4Z monovalent cation h antiporter subunit d HPS44_26270 ENOG4105SC1 monovalent cation H antiporter subunit E HPS44_26275 ENOG4105W4C monovalent cation H antiporter subunit F HPS44_26280 ENOG4105KJM monovalent cation h antiporter subunit g HPS44_26290 ENOG4106TCE HPS44_26295 ENOG4108Z6B deaminase HPS44_26300 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPS44_26305 ENOG4105C5H ABC transporter HPS44_26340 ENOG41080RH Thioredoxin HPS44_26345 ENOG4105DEN Luciferase family HPS44_26355 ENOG4105C7N Xanthine uracil vitamin C permease HPS44_26365 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HPS44_26375 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HPS44_26380 ENOG4108K5P (LipO)protein HPS44_26400 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HPS44_26420 ENOG4105EHV domain protein HPS44_26430 ENOG4105D6S protein involved in catabolism of external DNA HPS44_26435 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HPS44_26445 ENOG4105EIN peptidylprolyl cis-trans isomerase HPS44_26450 ENOG4108UJV acyl-CoA thioesterase i HPS44_26455 ENOG4108I0Y (ABC) transporter HPS44_26465 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component HPS44_26470 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_26475 ENOG4105ETT transcriptional Regulator, LysR family HPS44_26480 ENOG4105EAC phosphoserine phosphatase HPS44_26495 ENOG4105DND Transcriptional regulator HPS44_26510 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_26525 ENOG4105DND Transcriptional regulator HPS44_26530 ENOG4105CFM UPF0317 protein HPS44_26540 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_26550 ENOG4105C0Z ABC transporter HPS44_26555 ENOG4108IV0 ABC, transporter HPS44_26560 ENOG4108Z9W Outer membrane porin HPS44_26565 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_26580 ENOG4105E09 nadh pyrophosphatase HPS44_26605 ENOG4107R0W ABC transporter HPS44_26610 ENOG4105E5Q amino acid AbC transporter HPS44_26615 ENOG4105CDA abc transporter atp-binding protein HPS44_26620 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPS44_26625 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HPS44_26630 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HPS44_26645 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HPS44_26650 ENOG4105K4H Nlp p60 protein HPS44_26655 ENOG4105UGU tonB-dependent Receptor HPS44_26665 ENOG4105FYV Amp nucleosidase HPS44_26670 ENOG4108IQI permease HPS44_26680 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HPS44_26685 ENOG4105DSJ YicC domain protein HPS44_26690 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HPS44_26700 ENOG4105C1G acyl-Coa dehydrogenase HPS44_26710 ENOG4105BZU Histidine kinase HPS44_26715 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HPS44_26720 ENOG4105CSA Coproporphyrinogen iii oxidase HPS44_26730 ENOG4105CUX Signal transduction histidine kinase HPS44_26735 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_26740 ENOG4105EQ1 Transcriptional regulator HPS44_26750 ENOG4105EUB pirin domain protein HPS44_26755 ENOG4108S2Y peptide Chain Release factor HPS44_26770 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_26775 ENOG4105E0C molybdate abc transporter HPS44_26785 ENOG4105DP0 ferredoxin-NADP reductase HPS44_26805 ENOG4105DND Transcriptional regulator HPS44_26810 ENOG4105KME endoribonuclease L-psp HPS44_26815 ENOG4105CB5 ATP-dependent DNA helicase recG HPS44_26835 ENOG4106EYY HPS44_26840 ENOG4107TAE Glycosyl transferase (Group 1 HPS44_26865 ENOG4106PQC HPS44_26870 ENOG4105DBA pectate lyase HPS44_26880 ENOG4105CP9 extracellular ligand-binding receptor HPS44_26885 ENOG4107EXC regulatoR HPS44_26890 ENOG4105JJR Histidine kinase HPS44_26905 ENOG4108IJ9 (ABC) transporter HPS44_26915 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HPS44_26920 ENOG4105BZ7 extracellular solute-binding protein family 1 HPS44_26925 ENOG4105II7 pyrroline-5-carboxylate reductase HPS44_26930 ENOG4105EX9 Membrane HPS44_26940 ENOG4105CP9 extracellular ligand-binding receptor HPS44_26945 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_26950 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_26955 ENOG4105C0Z ABC transporter HPS44_26960 ENOG4108IV0 ABC, transporter HPS44_26985 ENOG4105RQF LysR family Transcriptional regulator HPS44_26990 ENOG4108K3A Glutathione S-transferase HPS44_26995 ENOG4105D8V Glucose sorbosone dehydrogenase HPS44_27005 ENOG4105DJP Membrane HPS44_27030 ENOG4105CYW agmatinase HPS44_27040 ENOG4105D01 (LipO)protein HPS44_27050 ENOG4105F27 Major Facilitator HPS44_27060 ENOG4107RN3 metallophosphoesterase HPS44_27070 ENOG4105DJ4 phosphatidylserine decarboxylase HPS44_27075 ENOG4105C5H ABC transporter HPS44_27100 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPS44_27105 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPS44_27110 ENOG4105BZU Histidine kinase HPS44_27125 ENOG4105D94 Major Facilitator Superfamily HPS44_27130 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HPS44_27150 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPS44_27155 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_27160 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_27210 ENOG4107R7Y intracellular protease Pfpi family HPS44_27230 ENOG4105C5I Dehydrogenase HPS44_27245 ENOG4105BZU Histidine kinase HPS44_27260 ENOG4105E0K tonB-dependent siderophore receptor HPS44_27280 ENOG4106RE7 Cytochrome HPS44_27295 ENOG4105EE5 Membrane protein terC HPS44_27310 ENOG4105JJR Histidine kinase HPS44_27355 ENOG4108VAU general secretion pathway protein G HPS44_27380 ENOG4107QHF type ii secretion system protein e HPS44_27385 ENOG4105D7Q type ii secretion system HPS44_27390 ENOG4108UPW ABC transporter HPS44_27440 ENOG4105X5Z General secretion pathway protein I HPS44_27480 ENOG4105BZU Histidine kinase HPS44_27485 ENOG4108Z4X TRANSCRIPTIONal HPS44_27495 ENOG4105BZU Histidine kinase HPS44_27525 ENOG4108IY8 ABC, transporter HPS44_27530 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HPS44_27535 ENOG4106FTQ Taurine ABC transporter, periplasmic HPS44_27560 ENOG4105CN1 protease HPS44_27580 ENOG4105IPI Membrane HPS44_27590 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPS44_27605 ENOG4107R7I amino acid HPS44_27650 ENOG4105KME endoribonuclease L-psp HPS44_27655 ENOG4105FC8 fad dependent oxidoreductase HPS44_27670 ENOG4105ERH Fumarylacetoacetate hydrolase HPS44_27700 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HPS44_27740 ENOG4108K3A Glutathione S-transferase HPS44_27745 ENOG4105DUM transcriptional regulator, lysR family HPS44_27755 ENOG4105CSH Transporter HPS44_27765 ENOG4105DWT malate dehydrogenase (quinone) HPS44_27795 ENOG4105CAU Arsenical resistance protein, ArsH HPS44_27805 ENOG4105D6J arsenicaL-resistance protein HPS44_27815 ENOG41085FC arsR family transcriptional regulator HPS44_27820 ENOG4105VN1 Heat shock protein HPS44_27855 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HPS44_27860 ENOG41080TK Universal stress protein HPS44_27875 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HPS44_27880 ENOG4105WH1 Two component transcriptional regulator luxr family HPS44_27895 ENOG41080XQ Signal transduction protein with cbs domains HPS44_27900 ENOG4105CY0 Metallo-Beta-Lactamase HPS44_27905 ENOG4108303 d-xylulose 5-phosphate d-fructose 6-phosphate phosphoketolase HPS44_27915 ENOG4108YV4 Universal stress protein HPS44_27925 ENOG41081QV Universal stress protein HPS44_27935 ENOG4105DZ0 fad dependent oxidoreductase HPS44_27955 ENOG4105CDA abc transporter atp-binding protein HPS44_27960 ENOG4105DRP amino acid AbC transporter HPS44_27965 ENOG4105EZ7 amino acid ABC transporter HPS44_27970 ENOG4107QXX ABC transporter HPS44_27975 ENOG4105C28 cystathionine HPS44_27980 ENOG4105RQF LysR family Transcriptional regulator HPS44_28000 ENOG4105C3U ABC transporter HPS44_28005 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_28010 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPS44_28015 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_28025 ENOG4105RQF LysR family Transcriptional regulator HPS44_28030 ENOG4105CHJ isochorismatase hydrolase HPS44_28035 ENOG41088CQ domain protein HPS44_28045 ENOG4105H1G trap transporter solute receptor taxi family HPS44_28050 ENOG4105DG7 nitrate ABC transporter HPS44_28055 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HPS44_28060 ENOG4105D7T ABC transporter HPS44_28070 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPS44_28080 ENOG4108PG2 copper resistance HPS44_28110 ENOG4105CTX dehydratase HPS44_28125 ENOG4105ECM Sensor protein basS pmrB HPS44_28130 ENOG4105ETX regulatoR HPS44_28140 ENOG4105EHG Permease protein HPS44_28145 ENOG41090JD Blue (Type 1) copper domain protein HPS44_28150 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_28155 ENOG4105C7B Threonine dehydratase HPS44_28165 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPS44_28170 ENOG4105E9K Isocitrate dehydrogenase HPS44_28175 ENOG4105DQR SNARE associated Golgi HPS44_28185 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HPS44_28190 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HPS44_28225 ENOG4105CNM Receptor HPS44_28240 ENOG4105TVJ transport system, permease HPS44_28245 ENOG4105E0A ABC, transporter HPS44_28250 ENOG4105CDA abc transporter atp-binding protein HPS44_28255 ENOG4105E5Q amino acid AbC transporter HPS44_28260 ENOG4105EAB amino acid AbC transporter HPS44_28265 ENOG4105EA8 2-Nitropropane dioxygenase HPS44_28270 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPS44_28280 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPS44_28290 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_28305 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HPS44_28315 ENOG4105CMQ Chloride channel HPS44_28320 ENOG41067TZ transcriptional regulator, MarR family HPS44_28330 ENOG4105BZU Histidine kinase HPS44_28335 ENOG4108ZXC Two component transcriptional regulator, luxr family HPS44_28360 ENOG4107R11 Transcriptional regulator HPS44_28380 ENOG4105CDA abc transporter atp-binding protein HPS44_28390 ENOG4105E5Q amino acid AbC transporter HPS44_28435 ENOG4108UQ8 endoribonuclease L-psp HPS44_28475 ENOG4108KB2 LysR family Transcriptional regulator HPS44_28480 ENOG4105DTQ mandelate racemase muconate lactonizing HPS44_28490 ENOG4105DRR Transcriptional regulator, GntR family HPS44_28495 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_28510 ENOG4105JSC dimethylmenaquinone methyltransferase HPS44_28535 ENOG4105DG7 nitrate ABC transporter HPS44_28540 ENOG4105I5W Transporter HPS44_28545 ENOG4105D7T ABC transporter HPS44_28590 ENOG4105WH1 Two component transcriptional regulator luxr family HPS44_28595 ENOG4105BZU Histidine kinase HPS44_28600 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HPS44_28605 ENOG4107B2H carbonic anhydrase HPS44_28610 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPS44_28615 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HPS44_28620 ENOG41076YT nitrate reductase, gamma subunit HPS44_28625 ENOG4105R3A Nitrate reductase HPS44_28630 ENOG4108IUE nitrate reductase beta subunit HPS44_28635 ENOG4105CRU nitrate reductase, alpha subunit HPS44_28640 ENOG4105DQQ Major facilitator superfamily MFS_1 HPS44_28665 ENOG4105HEI LysR family (Transcriptional regulator HPS44_28675 ENOG4105BZS acriflavin resistance protein HPS44_28680 ENOG4105BZS acriflavin resistance protein HPS44_28685 ENOG4105EMY transcriptional regulator HPS44_28725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_28745 ENOG4105EA8 2-Nitropropane dioxygenase HPS44_28760 ENOG4105BZU Histidine kinase HPS44_28765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPS44_28770 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) HPS44_28775 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HPS44_28785 ENOG4105E0X reductase HPS44_28790 ENOG4107U7B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HPS44_28835 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_28840 ENOG4105T38 integral membrane protein HPS44_28845 ENOG4105VCD cytoplasmic protein HPS44_28850 ENOG4105D22 carbon starvation protein HPS44_28865 ENOG4105EUJ GTP cyclohydrolase i HPS44_28870 ENOG4105FDR Membrane HPS44_28875 ENOG4107NQ8 LysR family Transcriptional regulator HPS44_28880 ENOG4106FTQ Taurine ABC transporter, periplasmic HPS44_28890 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HPS44_28915 ENOG4108S8N class II Aldolase HPS44_28920 ENOG4105I1J Autotransporter HPS44_28935 ENOG4105CKI cobalamin synthesis protein HPS44_28940 ENOG4105CI2 imidazolone-5-propionate hydrolase HPS44_28945 ENOG4108JQ6 ABC transporter HPS44_28950 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_28960 ENOG4108HIY periplasmic HPS44_28975 ENOG4108FUF Transcriptional regulator, IclR family HPS44_28980 ENOG4105C1J atp-dependent rna helicase HPS44_28985 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HPS44_29000 ENOG4105DSW Fusaric acid resistance protein HPS44_29005 ENOG4105ZQC membrane protein AaeX HPS44_29010 ENOG4105Y49 secretion protein, HlyD family HPS44_29025 ENOG4105C7K acetolactate synthase HPS44_29035 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HPS44_29045 ENOG4106KED esterase YpfH HPS44_29050 ENOG4108IQI permease HPS44_29055 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_29070 ENOG4105C0B DNA polymerase III (alpha subunit) HPS44_29085 ENOG4105EQ2 LysR family Transcriptional regulator HPS44_29090 ENOG4107S5I aldo keto reductase HPS44_29100 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HPS44_29125 ENOG4105DRP amino acid AbC transporter HPS44_29130 ENOG4105EAD ABC transporter HPS44_29135 ENOG4105EAB amino acid AbC transporter HPS44_29145 ENOG4105JSC dimethylmenaquinone methyltransferase HPS44_29195 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPS44_29200 ENOG4108VKM cytochrome b561 HPS44_29235 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_29255 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPS44_29270 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HPS44_29275 ENOG4108IUZ ABC transporter HPS44_29280 ENOG4105C0Z ABC transporter HPS44_29285 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_29300 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HPS44_29320 ENOG4105E0K tonB-dependent siderophore receptor HPS44_29335 ENOG4108FUF Transcriptional regulator, IclR family HPS44_29345 ENOG4105CSH Transporter HPS44_29350 ENOG4105CPC Aldo Keto reductase HPS44_29365 ENOG4105PF9 Transcriptional regulator HPS44_29385 ENOG4105EWC Purine nucleoside phosphorylase HPS44_29395 ENOG4105R1U AraC Family Transcriptional Regulator HPS44_29410 ENOG4107R0U MotA TolQ exbB proton channel HPS44_29420 ENOG4105GRZ Ycii-related protein HPS44_29425 ENOG4105GRZ Ycii-related protein HPS44_29435 ENOG4105CHP RNA polymerase HPS44_29445 ENOG4105DXC membrane HPS44_29455 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HPS44_29465 ENOG4105DUM transcriptional regulator, lysR family HPS44_29490 ENOG4108K3A Glutathione S-transferase