locus-tag	class	description
HPS44_00045	COG1846	Transcriptional regulator
HPS44_00050	COG3541	Predicted nucleotidyltransferase
HPS44_00110	COG1360	Flagellar Motor Protein
HPS44_00120	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HPS44_00150	COG3501	Rhs element vgr protein
HPS44_00210	COG3501	Rhs element vgr protein
HPS44_00300	COG0625	glutathione transferase activity
HPS44_00305	COG2032	superoxide dismutase activity
HPS44_00310	COG2733	membrane
HPS44_00320	COG0148	phosphopyruvate hydratase activity
HPS44_00345	COG0583	DNA-binding transcription factor activity
HPS44_00350	COG1024	Enoyl-CoA hydratase
HPS44_00350	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_00355	COG0183	Belongs to the thiolase family
HPS44_00360	COG1960	acyl-CoA dehydrogenase activity
HPS44_00365	COG1960	acyl-CoA dehydrogenase activity
HPS44_00370	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_00395	COG0583	DNA-binding transcription factor activity
HPS44_00405	COG1846	Transcriptional regulator
HPS44_00410	COG0477	Major facilitator Superfamily
HPS44_00415	COG2010	Cytochrome c
HPS44_00415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPS44_00420	COG2080	2 iron, 2 sulfur cluster binding
HPS44_00430	COG0596	Alpha beta hydrolase
HPS44_00435	COG2309	aminopeptidase activity
HPS44_00440	COG1335	isochorismatase
HPS44_00445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPS44_00445	COG2010	Cytochrome c
HPS44_00455	COG1522	sequence-specific DNA binding
HPS44_00465	COG3842	ATPase activity
HPS44_00475	COG4149	molybdate abc transporter
HPS44_00480	COG2203	Gaf domain
HPS44_00480	COG4251	negative regulation of phosphorylation
HPS44_00480	COG3706	GGDEF domain
HPS44_00480	COG5001	Diguanylate cyclase
HPS44_00485	COG2201	protein-glutamate methylesterase activity
HPS44_00510	COG0840	transmembrane signaling receptor activity
HPS44_00515	COG0154	amidase activity
HPS44_00530	COG0583	DNA-binding transcription factor activity
HPS44_00560	COG0456	acetyltransferase
HPS44_00570	COG5001	Diguanylate cyclase
HPS44_00570	COG4251	negative regulation of phosphorylation
HPS44_00570	COG3706	GGDEF domain
HPS44_00570	COG2203	Gaf domain
HPS44_00595	COG0477	Major facilitator Superfamily
HPS44_00630	COG0165	Argininosuccinate lyase
HPS44_00645	COG0583	DNA-binding transcription factor activity
HPS44_00660	COG2205	protein histidine kinase activity
HPS44_00680	COG2207	Transcriptional regulator
HPS44_00685	COG2267	carboxylic ester hydrolase activity
HPS44_00695	COG4221	oxidoreductase activity
HPS44_00700	COG2207	Transcriptional regulator
HPS44_00740	COG0640	Transcriptional regulator
HPS44_00745	COG0640	Transcriptional regulator
HPS44_00755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPS44_00760	COG0583	DNA-binding transcription factor activity
HPS44_00765	COG0431	NADPH-dependent FMN reductase
HPS44_00785	COG4264	IucA IucC family
HPS44_00810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HPS44_00815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPS44_00820	COG1205	dead DEAH box helicase
HPS44_00820	COG1111	helicase
HPS44_00835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPS44_00835	COG0519	Catalyzes the synthesis of GMP from XMP
HPS44_00865	COG0583	DNA-binding transcription factor activity
HPS44_00875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS44_00895	COG0583	DNA-binding transcription factor activity
HPS44_00900	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_00945	COG2072	flavoprotein involved in K transport
HPS44_00950	COG0601	transmembrane transport
HPS44_00955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_00965	COG4608	Belongs to the ABC transporter superfamily
HPS44_00970	COG0747	negative chemotaxis
HPS44_01000	COG4774	siderophore transport
HPS44_01020	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS44_01045	COG0583	DNA-binding transcription factor activity
HPS44_01105	COG1024	Enoyl-CoA hydratase
HPS44_01110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_01115	COG1960	acyl-CoA dehydrogenase activity
HPS44_01125	COG0583	DNA-binding transcription factor activity
HPS44_01130	COG3618	amidohydrolase
HPS44_01145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPS44_01170	COG5001	Diguanylate cyclase
HPS44_01175	COG4774	siderophore transport
HPS44_01180	COG4774	siderophore transport
HPS44_01195	COG0583	DNA-binding transcription factor activity
HPS44_01245	COG1953	Uracil, thiamine, allantoin
HPS44_01280	COG2198	Histidine kinase
HPS44_01280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_01280	COG0784	Response regulator, receiver
HPS44_01280	COG2205	protein histidine kinase activity
HPS44_01285	COG0745	RESPONSE REGULATOR receiver
HPS44_01285	COG3292	Two component regulator propeller
HPS44_01285	COG2205	protein histidine kinase activity
HPS44_01310	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_01315	COG0583	DNA-binding transcription factor activity
HPS44_01320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_01330	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_01340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPS44_01355	COG0583	DNA-binding transcription factor activity
HPS44_01380	COG0745	RESPONSE REGULATOR receiver
HPS44_01400	COG0047	phosphoribosylformylglycinamidine synthase activity
HPS44_01400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPS44_01415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_01425	COG0613	PHP domain protein
HPS44_01440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS44_01450	COG0583	DNA-binding transcription factor activity
HPS44_01460	COG0583	DNA-binding transcription factor activity
HPS44_01465	COG0477	Major facilitator Superfamily
HPS44_01470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS44_01480	COG0159	tryptophan synthase activity
HPS44_01505	COG0277	FAD linked oxidase domain protein
HPS44_01520	COG3119	arylsulfatase activity
HPS44_01555	COG2149	membrane
HPS44_01580	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPS44_01590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPS44_01595	COG0459	protein refolding
HPS44_01640	COG0714	Associated with various cellular activities
HPS44_01660	COG2304	oxidoreductase activity
HPS44_01675	COG3119	arylsulfatase activity
HPS44_01685	COG1280	lysine exporter protein (LysE YggA)
HPS44_01715	COG0633	Ferredoxin
HPS44_01725	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_01745	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPS44_01765	COG4604	ABC transporter, ATP-binding protein
HPS44_01770	COG4605	iron ion homeostasis
HPS44_01775	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS44_01780	COG4607	ABC-type enterochelin transport system periplasmic component
HPS44_01785	COG4771	TonB-dependent receptor
HPS44_01790	COG0745	RESPONSE REGULATOR receiver
HPS44_01800	COG0084	hydrolase, TatD family'
HPS44_01805	COG1136	(ABC) transporter
HPS44_01825	COG2271	Major facilitator Superfamily
HPS44_01835	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_01840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPS44_01855	COG3135	benzoate transporter
HPS44_01860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPS44_01870	COG0183	Belongs to the thiolase family
HPS44_01875	COG1022	Amp-dependent synthetase and ligase
HPS44_01905	COG1024	Enoyl-CoA hydratase
HPS44_01915	COG1803	Methylglyoxal synthase
HPS44_01920	COG2975	iron-sulfur cluster assembly
HPS44_01925	COG0633	Ferredoxin
HPS44_01930	COG0443	Heat shock 70 kDa protein
HPS44_01935	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPS44_01940	COG0316	Belongs to the HesB IscA family
HPS44_01945	COG0822	iron-sulfur transferase activity
HPS44_01950	COG1104	cysteine desulfurase activity
HPS44_01960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPS44_01965	COG0556	nucleotide-excision repair
HPS44_01975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPS44_01980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPS44_01985	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPS44_01990	COG0740	serine-type endopeptidase activity
HPS44_01995	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPS44_02000	COG0501	Belongs to the peptidase M48B family
HPS44_02010	COG1278	Cold shock
HPS44_02020	COG1278	Cold shock
HPS44_02045	COG0251	oxidation-reduction process
HPS44_02055	COG0583	DNA-binding transcription factor activity
HPS44_02090	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPS44_02115	COG0277	FAD linked oxidase domain protein
HPS44_02125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPS44_02130	COG2814	Major facilitator Superfamily
HPS44_02165	COG2171	N-acyltransferase activity
HPS44_02175	COG2890	protein-(glutamine-N5) methyltransferase activity
HPS44_02180	COG0488	(ABC) transporter
HPS44_02195	COG4771	TonB-dependent receptor
HPS44_02200	COG4771	TonB-dependent receptor
HPS44_02205	COG4771	TonB-dependent receptor
HPS44_02215	COG1858	cytochrome C peroxidase
HPS44_02225	COG0210	DNA helicase
HPS44_02240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPS44_02240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPS44_02245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPS44_02250	COG0196	riboflavin kinase activity
HPS44_02255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPS44_02260	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPS44_02265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPS44_02320	COG1902	pentaerythritol trinitrate reductase activity
HPS44_02325	COG1126	abc transporter atp-binding protein
HPS44_02330	COG0765	amino acid transport
HPS44_02335	COG0765	amino acid transport
HPS44_02340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_02350	COG2423	ornithine cyclodeaminase activity
HPS44_02355	COG1764	response to oxidative stress
HPS44_02365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS44_02370	COG0625	glutathione transferase activity
HPS44_02380	COG4178	(ABC) transporter
HPS44_02390	COG4771	TonB-dependent receptor
HPS44_02405	COG2271	Major facilitator Superfamily
HPS44_02435	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPS44_02435	COG0506	proline dehydrogenase activity
HPS44_02435	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPS44_02445	COG3008	intermembrane lipid transfer
HPS44_02450	COG2995	paraquat-inducible protein a
HPS44_02460	COG4953	penicillin-binding protein 1C
HPS44_02470	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPS44_02475	COG1278	Cold shock
HPS44_02485	COG0183	Belongs to the thiolase family
HPS44_02490	COG0038	chloride channel
HPS44_02500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPS44_02510	COG1570	exodeoxyribonuclease VII activity
HPS44_02515	COG0811	peptide transport
HPS44_02525	COG1663	tetraacyldisaccharide 4'-kinase activity
HPS44_02535	COG2835	tetraacyldisaccharide 4'-kinase activity
HPS44_02540	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPS44_02545	COG0563	adenylate kinase activity
HPS44_02555	COG0728	peptidoglycan biosynthetic process
HPS44_02565	COG0268	Binds directly to 16S ribosomal RNA
HPS44_02570	COG0583	DNA-binding transcription factor activity
HPS44_02585	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_02590	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPS44_02595	COG2186	Transcriptional regulator
HPS44_02605	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_02615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS44_02645	COG3384	dioxygenase
HPS44_02650	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_02665	COG3971	2-oxopent-4-enoate hydratase activity
HPS44_02675	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_02680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPS44_02685	COG1562	ergosterol biosynthetic process
HPS44_02690	COG1562	ergosterol biosynthetic process
HPS44_02700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPS44_02715	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS44_02730	COG5564	TIM-barrel signal transduction protein
HPS44_02735	COG5441	Belongs to the UPF0261 family
HPS44_02760	COG0542	response to heat
HPS44_02770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPS44_02780	COG0477	Major facilitator Superfamily
HPS44_02800	COG0494	nUDIX hydrolase
HPS44_02805	COG0583	DNA-binding transcription factor activity
HPS44_02810	COG0443	Heat shock 70 kDa protein
HPS44_02855	COG3530	Putative quorum-sensing-regulated virulence factor
HPS44_02870	COG0625	glutathione transferase activity
HPS44_02900	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_02910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS44_02960	COG1522	sequence-specific DNA binding
HPS44_02995	COG0519	Catalyzes the synthesis of GMP from XMP
HPS44_03015	COG0519	Catalyzes the synthesis of GMP from XMP
HPS44_03020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPS44_03025	COG2951	lytic endotransglycosylase activity
HPS44_03035	COG0583	DNA-binding transcription factor activity
HPS44_03045	COG2272	Belongs to the type-B carboxylesterase lipase family
HPS44_03050	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_03055	COG1309	transcriptional regulator
HPS44_03065	COG1473	amidohydrolase
HPS44_03075	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HPS44_03090	COG3618	amidohydrolase
HPS44_03095	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_03130	COG2011	ABC-type metal ion transport system permease component
HPS44_03135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPS44_03140	COG1464	Belongs to the NlpA lipoprotein family
HPS44_03150	COG2814	Major facilitator Superfamily
HPS44_03160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPS44_03165	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_03205	COG2837	iron assimilation
HPS44_03230	COG0583	DNA-binding transcription factor activity
HPS44_03235	COG2814	Major facilitator Superfamily
HPS44_03240	COG2169	Transcriptional regulator
HPS44_03270	COG1272	protein, Hemolysin III
HPS44_03295	COG4638	Rieske (2fe-2S)
HPS44_03310	COG0604	alcohol dehydrogenase
HPS44_03310	COG3321	synthase
HPS44_03325	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_03330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_03355	COG0183	Belongs to the thiolase family
HPS44_03370	COG0842	Transport permease protein
HPS44_03375	COG1131	(ABC) transporter
HPS44_03385	COG2197	response regulator
HPS44_03390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS44_03390	COG1116	anion transmembrane transporter activity
HPS44_03395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_03400	COG1116	anion transmembrane transporter activity
HPS44_03405	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HPS44_03425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS44_03455	COG0811	peptide transport
HPS44_03515	COG1396	sequence-specific DNA binding
HPS44_03520	COG0235	Class ii aldolase
HPS44_03530	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_03540	COG0583	DNA-binding transcription factor activity
HPS44_03560	COG0583	DNA-binding transcription factor activity
HPS44_03565	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_03575	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_03610	COG1024	Enoyl-CoA hydratase
HPS44_03670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS44_03695	COG2084	Dehydrogenase
HPS44_03700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS44_03705	COG0683	leucine binding
HPS44_03765	COG4191	Histidine kinase
HPS44_03780	COG0583	DNA-binding transcription factor activity
HPS44_03830	COG3384	dioxygenase
HPS44_03875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS44_03880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPS44_03885	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPS44_03900	COG1609	Transcriptional regulator
HPS44_03905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_03910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS44_03920	COG1850	ribulose-bisphosphate carboxylase activity
HPS44_03935	COG0505	Belongs to the CarA family
HPS44_03955	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HPS44_03955	COG3608	succinylglutamate desuccinylase aspartoacylase
HPS44_03960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPS44_03975	COG2207	Transcriptional regulator
HPS44_03980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_04065	COG2192	nodulation
HPS44_04075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPS44_04080	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_04085	COG0438	transferase activity, transferring glycosyl groups
HPS44_04095	COG5265	(ABC) transporter
HPS44_04115	COG0668	transmembrane transport
HPS44_04125	COG0166	Belongs to the GPI family
HPS44_04135	COG3685	Protein conserved in bacteria
HPS44_04155	COG0387	Pfam Sodium calcium exchanger
HPS44_04160	COG3568	Endonuclease Exonuclease Phosphatase
HPS44_04165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS44_04170	COG0392	lysyltransferase activity
HPS44_04175	COG0297	glycogen (starch) synthase activity
HPS44_04180	COG0366	Alpha amylase catalytic
HPS44_04185	COG0366	Alpha amylase catalytic
HPS44_04200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPS44_04205	COG1640	4-alpha-glucanotransferase
HPS44_04215	COG1113	amino acid transport
HPS44_04240	COG1546	Belongs to the CinA family
HPS44_04240	COG1058	Belongs to the CinA family
HPS44_04250	COG3852	Histidine kinase
HPS44_04280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS44_04290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPS44_04300	COG0477	Major facilitator Superfamily
HPS44_04315	COG4206	TonB-dependent receptor
HPS44_04380	COG1414	Transcriptional regulator
HPS44_04385	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS44_04390	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_04400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPS44_04405	COG3958	Transketolase
HPS44_04410	COG3959	Transketolase, thiamine diphosphate binding domain
HPS44_04415	COG1802	Transcriptional regulator
HPS44_04420	COG0371	Dehydrogenase
HPS44_04425	COG3246	L-lysine catabolic process to acetate
HPS44_04435	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_04445	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_04460	COG0604	alcohol dehydrogenase
HPS44_04460	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_04460	COG3321	synthase
HPS44_04465	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_04495	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_04500	COG0583	DNA-binding transcription factor activity
HPS44_04505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPS44_04515	COG3384	dioxygenase
HPS44_04530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPS44_04585	COG4964	Belongs to the GSP D family
HPS44_04630	COG1846	Transcriptional regulator
HPS44_04635	COG4172	Belongs to the ABC transporter superfamily
HPS44_04640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_04645	COG0601	transmembrane transport
HPS44_04660	COG0598	Magnesium transport protein CorA
HPS44_04680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPS44_04695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPS44_04700	COG1045	serine acetyltransferase
HPS44_04705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPS44_04710	COG0166	Belongs to the GPI family
HPS44_04715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPS44_04720	COG0489	protein tyrosine kinase activity
HPS44_04720	COG3206	protein involved in exopolysaccharide biosynthesis
HPS44_04725	COG1596	polysaccharide export
HPS44_04735	COG1051	belongs to the nudix hydrolase family
HPS44_04755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS44_04780	COG0463	Glycosyl transferase, family 2
HPS44_04785	COG0110	maltose O-acetyltransferase activity
HPS44_04790	COG0297	glycogen (starch) synthase activity
HPS44_04795	COG2197	response regulator
HPS44_04800	COG2197	response regulator
HPS44_04810	COG1309	transcriptional regulator
HPS44_04815	COG1960	acyl-CoA dehydrogenase activity
HPS44_04825	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_04825	COG1024	Enoyl-CoA hydratase
HPS44_04835	COG1024	Enoyl-CoA hydratase
HPS44_04835	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_04840	COG0183	Belongs to the thiolase family
HPS44_04855	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_04865	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_04875	COG1132	(ABC) transporter
HPS44_04885	COG3395	kinase activity
HPS44_04890	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPS44_04900	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS44_04905	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPS44_04910	COG1024	Enoyl-CoA hydratase
HPS44_04920	COG1414	Transcriptional regulator
HPS44_04930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPS44_04950	COG0583	DNA-binding transcription factor activity
HPS44_04990	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPS44_04995	COG1309	transcriptional regulator
HPS44_05005	COG1051	belongs to the nudix hydrolase family
HPS44_05010	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HPS44_05020	COG0784	Response regulator, receiver
HPS44_05020	COG2205	protein histidine kinase activity
HPS44_05030	COG2205	protein histidine kinase activity
HPS44_05030	COG0784	Response regulator, receiver
HPS44_05045	COG2863	cytochrome
HPS44_05050	COG3258	Cytochrome c
HPS44_05065	COG3278	Belongs to the heme-copper respiratory oxidase family
HPS44_05085	COG0348	domain, Protein
HPS44_05105	COG4695	Portal protein
HPS44_05285	COG0527	aspartate kinase activity
HPS44_05290	COG0037	tRNA processing
HPS44_05295	COG0825	malonyl-CoA metabolic process
HPS44_05305	COG0215	cysteine-tRNA ligase activity
HPS44_05320	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPS44_05325	COG1968	undecaprenyl-diphosphatase activity
HPS44_05330	COG1253	flavin adenine dinucleotide binding
HPS44_05345	COG4263	nitrous-oxide reductase activity
HPS44_05360	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPS44_05370	COG1477	protein flavinylation
HPS44_05375	COG4804	nuclease activity
HPS44_05400	COG0668	transmembrane transport
HPS44_05440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS44_05445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_05450	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HPS44_05485	COG3360	Dodecin
HPS44_05495	COG0583	DNA-binding transcription factor activity
HPS44_05500	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_05550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPS44_05555	COG2850	peptidyl-arginine hydroxylation
HPS44_05565	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPS44_05570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_05575	COG1994	Peptidase M50
HPS44_05580	COG0009	L-threonylcarbamoyladenylate synthase
HPS44_05585	COG2321	neutral zinc metallopeptidase
HPS44_05645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS44_05650	COG3969	phosphoadenosine phosphosulfate
HPS44_05660	COG1475	DNA binding
HPS44_05665	COG0642	Histidine kinase
HPS44_05685	COG3188	usher protein
HPS44_05690	COG3121	Chaperone
HPS44_05705	COG5001	Diguanylate cyclase
HPS44_05705	COG3300	MHYT domain
HPS44_05715	COG2197	response regulator
HPS44_05745	COG3121	Chaperone
HPS44_05750	COG3188	usher protein
HPS44_05785	COG4221	oxidoreductase activity
HPS44_05790	COG3387	PFAM Glycoside hydrolase 15-related
HPS44_05805	COG0840	transmembrane signaling receptor activity
HPS44_05810	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_05815	COG1280	lysine exporter protein (LysE YggA)
HPS44_05830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS44_05850	COG2084	Dehydrogenase
HPS44_05865	COG1802	Transcriptional regulator
HPS44_05880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS44_05905	COG0745	RESPONSE REGULATOR receiver
HPS44_05910	COG2205	protein histidine kinase activity
HPS44_05915	COG1764	response to oxidative stress
HPS44_05920	COG0583	DNA-binding transcription factor activity
HPS44_05925	COG0601	transmembrane transport
HPS44_05930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_05935	COG0444	Belongs to the ABC transporter superfamily
HPS44_05940	COG4608	Belongs to the ABC transporter superfamily
HPS44_05955	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_05960	COG0586	Pfam SNARE associated Golgi protein
HPS44_05965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_05970	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPS44_06020	COG3546	catalase activity
HPS44_06055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPS44_06080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_06085	COG0765	amino acid transport
HPS44_06095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_06105	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_06130	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_06150	COG0348	domain, Protein
HPS44_06170	COG3278	Belongs to the heme-copper respiratory oxidase family
HPS44_06185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPS44_06190	COG0156	8-amino-7-oxononanoate synthase activity
HPS44_06200	COG4106	trans-aconitate 2-methyltransferase activity
HPS44_06200	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPS44_06205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPS44_06205	COG4106	trans-aconitate 2-methyltransferase activity
HPS44_06220	COG2224	Isocitrate lyase
HPS44_06230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPS44_06230	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPS44_06235	COG1858	cytochrome C peroxidase
HPS44_06240	COG0583	DNA-binding transcription factor activity
HPS44_06245	COG0473	3-isopropylmalate dehydrogenase activity
HPS44_06255	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPS44_06270	COG0736	holo-[acyl-carrier-protein] synthase activity
HPS44_06275	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPS44_06285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS44_06290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_06315	COG3842	ATPase activity
HPS44_06320	COG4149	molybdate abc transporter
HPS44_06325	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPS44_06330	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HPS44_06355	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPS44_06365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_06375	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPS44_06385	COG0667	Aldo Keto reductase
HPS44_06395	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_06400	COG1024	Enoyl-CoA hydratase
HPS44_06410	COG1802	Transcriptional regulator
HPS44_06420	COG0183	Belongs to the thiolase family
HPS44_06425	COG1960	acyl-CoA dehydrogenase activity
HPS44_06430	COG1960	acyl-CoA dehydrogenase activity
HPS44_06435	COG0583	DNA-binding transcription factor activity
HPS44_06460	COG4213	ABC transporter substrate-binding protein
HPS44_06465	COG1129	ABC transporter
HPS44_06470	COG4214	carbohydrate transport
HPS44_06475	COG2706	6-phosphogluconolactonase activity
HPS44_06480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS44_06495	COG3448	diguanylate cyclase activity
HPS44_06495	COG4175	Glycine betaine
HPS44_06500	COG4176	ABC-type proline glycine betaine transport system permease component
HPS44_06510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS44_06515	COG2814	Major facilitator Superfamily
HPS44_06520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPS44_06525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPS44_06560	COG1686	Belongs to the peptidase S11 family
HPS44_06570	COG1846	Transcriptional regulator
HPS44_06575	COG2814	Major facilitator Superfamily
HPS44_06580	COG0495	leucyl-tRNA aminoacylation
HPS44_06595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPS44_06615	COG0154	amidase activity
HPS44_06625	COG0477	Major facilitator Superfamily
HPS44_06635	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_06650	COG0583	DNA-binding transcription factor activity
HPS44_06700	COG0583	DNA-binding transcription factor activity
HPS44_06705	COG0427	acetyl-CoA hydrolase
HPS44_06710	COG0583	DNA-binding transcription factor activity
HPS44_06715	COG3264	Mechanosensitive ion channel
HPS44_06715	COG1511	domain protein
HPS44_06765	COG3842	ATPase activity
HPS44_06775	COG1177	transmembrane transport
HPS44_06780	COG3938	Belongs to the proline racemase family
HPS44_06795	COG0517	IMP dehydrogenase activity
HPS44_06825	COG0500	methyltransferase
HPS44_06835	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HPS44_06850	COG0667	Aldo Keto reductase
HPS44_06855	COG2207	Transcriptional regulator
HPS44_06865	COG1595	DNA-templated transcription, initiation
HPS44_06880	COG2841	Protein conserved in bacteria
HPS44_06895	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS44_06900	COG0438	transferase activity, transferring glycosyl groups
HPS44_06915	COG2814	Major facilitator Superfamily
HPS44_06920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPS44_06945	COG0248	Ppx GppA phosphatase
HPS44_06955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPS44_06965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPS44_06970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPS44_06975	COG1534	Rna-binding protein
HPS44_06980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPS44_06985	COG0840	transmembrane signaling receptor activity
HPS44_06990	COG2233	PERMEase
HPS44_07010	COG3842	ATPase activity
HPS44_07025	COG4221	oxidoreductase activity
HPS44_07035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPS44_07040	COG0505	Belongs to the CarA family
HPS44_07060	COG0745	RESPONSE REGULATOR receiver
HPS44_07075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_07085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS44_07090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_07105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPS44_07115	COG1074	ATP-dependent DNA helicase activity
HPS44_07135	COG2070	2-Nitropropane dioxygenase
HPS44_07155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_07170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS44_07175	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_07190	COG1686	Belongs to the peptidase S11 family
HPS44_07210	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HPS44_07215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPS44_07220	COG4974	Belongs to the 'phage' integrase family
HPS44_07225	COG0583	DNA-binding transcription factor activity
HPS44_07230	COG0028	Belongs to the TPP enzyme family
HPS44_07275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPS44_07320	COG0028	Belongs to the TPP enzyme family
HPS44_07325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_07340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS44_07345	COG1414	Transcriptional regulator
HPS44_07350	COG0009	L-threonylcarbamoyladenylate synthase
HPS44_07355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPS44_07360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPS44_07365	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPS44_07375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPS44_07395	COG1301	dicarboxylic acid transport
HPS44_07405	COG3454	Phosphonate metabolism
HPS44_07410	COG4778	phosphonate C-P lyase system protein PhnL
HPS44_07415	COG4107	phosphonate C-P lyase system protein PhnK
HPS44_07420	COG3627	carbon phosphorus lyase activity
HPS44_07425	COG3626	phosphonate metabolism
HPS44_07430	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HPS44_07435	COG3624	Phosphonate C-P lyase system protein PhnG
HPS44_07440	COG2188	Transcriptional regulator
HPS44_07445	COG3454	Phosphonate metabolism
HPS44_07450	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HPS44_07455	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HPS44_07460	COG0583	DNA-binding transcription factor activity
HPS44_07465	COG0405	Gamma-glutamyltransferase
HPS44_07480	COG3639	organic phosphonate transmembrane transporter activity
HPS44_07485	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HPS44_07490	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HPS44_07500	COG0640	Transcriptional regulator
HPS44_07510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPS44_07520	COG0739	heme binding
HPS44_07530	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPS44_07540	COG0306	phosphate transporter
HPS44_07575	COG0625	glutathione transferase activity
HPS44_07595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPS44_07600	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPS44_07615	COG0126	phosphoglycerate kinase activity
HPS44_07620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPS44_07625	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPS44_07635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPS44_07640	COG2732	(Barnase) inhibitor
HPS44_07650	COG0281	malic enzyme
HPS44_07650	COG0280	phosphate acetyltransferase
HPS44_07675	COG0741	lytic transglycosylase activity
HPS44_07680	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPS44_07695	COG4575	ribosome binding
HPS44_07705	COG1116	anion transmembrane transporter activity
HPS44_07710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_07715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS44_07720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPS44_07720	COG1648	precorrin-2 dehydrogenase activity
HPS44_07725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPS44_07730	COG2027	D-alanyl-D-alanine carboxypeptidase
HPS44_07745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS44_07755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPS44_07760	COG0343	queuine tRNA-ribosyltransferase activity
HPS44_07770	COG3077	Addiction module antitoxin, RelB DinJ family
HPS44_07775	COG1862	Preprotein translocase
HPS44_07780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPS44_07785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPS44_07805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPS44_07825	COG1702	phosphate starvation-inducible protein PhoH
HPS44_07830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPS44_07835	COG4535	Mg2 and Co2 transporter CorC
HPS44_07840	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPS44_07845	COG0667	Aldo Keto reductase
HPS44_07890	COG0697	spore germination
HPS44_07900	COG0678	peroxiredoxin activity
HPS44_07910	COG0412	Dienelactone hydrolase
HPS44_07920	COG0315	cyclic pyranopterin monophosphate synthase activity
HPS44_07930	COG0314	molybdopterin synthase activity
HPS44_07935	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPS44_07940	COG0303	'Molybdopterin
HPS44_07950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPS44_07970	COG3383	formate dehydrogenase (NAD+) activity
HPS44_07975	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPS44_07985	COG2223	nitrite transmembrane transporter activity
HPS44_08010	COG0583	DNA-binding transcription factor activity
HPS44_08015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPS44_08030	COG2205	protein histidine kinase activity
HPS44_08035	COG0745	RESPONSE REGULATOR receiver
HPS44_08050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPS44_08065	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_08085	COG2828	Protein conserved in bacteria
HPS44_08090	COG0583	DNA-binding transcription factor activity
HPS44_08135	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_08160	COG4774	siderophore transport
HPS44_08175	COG0671	phosphoesterase, PA-phosphatase related
HPS44_08190	COG1666	GTP binding
HPS44_08195	COG1120	ATPase activity
HPS44_08200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS44_08205	COG4558	Periplasmic binding protein
HPS44_08210	COG3720	iron ion transport
HPS44_08220	COG3712	iron ion homeostasis
HPS44_08225	COG1595	DNA-templated transcription, initiation
HPS44_08240	COG2378	regulation of single-species biofilm formation
HPS44_08265	COG0583	DNA-binding transcription factor activity
HPS44_08270	COG1113	amino acid transport
HPS44_08280	COG1522	sequence-specific DNA binding
HPS44_08285	COG1272	protein, Hemolysin III
HPS44_08290	COG3191	aminopeptidase activity
HPS44_08295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_08300	COG0765	amino acid transport
HPS44_08310	COG4942	peptidase
HPS44_08330	COG1999	signal sequence binding
HPS44_08345	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HPS44_08355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS44_08360	COG1845	cytochrome c oxidase, subunit III
HPS44_08365	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPS44_08405	COG0280	phosphate acetyltransferase
HPS44_08405	COG0281	malic enzyme
HPS44_08420	COG0697	spore germination
HPS44_08455	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_08465	COG0583	DNA-binding transcription factor activity
HPS44_08485	COG1396	sequence-specific DNA binding
HPS44_08490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS44_08515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPS44_08530	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPS44_08535	COG1285	pathogenesis
HPS44_08540	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_08545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPS44_08560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPS44_08575	COG3712	iron ion homeostasis
HPS44_08580	COG1595	DNA-templated transcription, initiation
HPS44_08590	COG4221	oxidoreductase activity
HPS44_08595	COG4773	Receptor
HPS44_08615	COG5001	Diguanylate cyclase
HPS44_08620	COG0330	HflC and HflK could
HPS44_08645	COG2807	transmembrane transport
HPS44_08650	COG2207	Transcriptional regulator
HPS44_08655	COG4106	trans-aconitate 2-methyltransferase activity
HPS44_08670	COG0583	DNA-binding transcription factor activity
HPS44_08710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPS44_08715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_08720	COG0477	Major facilitator Superfamily
HPS44_08725	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPS44_08730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS44_08735	COG1845	cytochrome c oxidase, subunit III
HPS44_08740	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPS44_08750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_08755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_08760	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_08770	COG2814	Major facilitator Superfamily
HPS44_08785	COG0625	glutathione transferase activity
HPS44_08845	COG3707	response regulator
HPS44_08850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPS44_08850	COG2146	nitrite reductase [NAD(P)H] activity
HPS44_08855	COG2146	nitrite reductase [NAD(P)H] activity
HPS44_08855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPS44_08860	COG0243	molybdopterin cofactor binding
HPS44_08870	COG0667	Aldo Keto reductase
HPS44_08890	COG0583	DNA-binding transcription factor activity
HPS44_08895	COG0023	Translation Initiation Factor
HPS44_08905	COG0456	acetyltransferase
HPS44_08905	COG0454	-acetyltransferase
HPS44_08910	COG0583	DNA-binding transcription factor activity
HPS44_08915	COG4948	Mandelate Racemase Muconate Lactonizing
HPS44_08930	COG0840	transmembrane signaling receptor activity
HPS44_08935	COG2203	Gaf domain
HPS44_08935	COG2199	diguanylate cyclase activity
HPS44_08940	COG0640	Transcriptional regulator
HPS44_08950	COG0740	serine-type endopeptidase activity
HPS44_08955	COG2814	Major facilitator Superfamily
HPS44_08985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_08995	COG0596	Alpha beta hydrolase
HPS44_09005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPS44_09015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS44_09020	COG0583	DNA-binding transcription factor activity
HPS44_09055	COG0028	Belongs to the TPP enzyme family
HPS44_09070	COG1230	cation diffusion facilitator family transporter
HPS44_09090	COG1132	(ABC) transporter
HPS44_09100	COG1201	RNA secondary structure unwinding
HPS44_09105	COG1793	dna ligase
HPS44_09110	COG1793	dna ligase
HPS44_09110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPS44_09145	COG1960	acyl-CoA dehydrogenase activity
HPS44_09155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_09160	COG0697	spore germination
HPS44_09170	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_09180	COG0436	Aminotransferase
HPS44_09185	COG0583	DNA-binding transcription factor activity
HPS44_09190	COG0583	DNA-binding transcription factor activity
HPS44_09215	COG0583	DNA-binding transcription factor activity
HPS44_09220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_09225	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_09230	COG4948	Mandelate Racemase Muconate Lactonizing
HPS44_09245	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_09290	COG1595	DNA-templated transcription, initiation
HPS44_09325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPS44_09375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS44_09405	COG2200	EAL domain
HPS44_09425	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS44_09430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_09440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPS44_09445	COG0459	protein refolding
HPS44_09455	COG1846	Transcriptional regulator
HPS44_09475	COG1917	Cupin 2, conserved barrel domain protein
HPS44_09500	COG1137	ATPase activity
HPS44_09510	COG0246	Mannitol dehydrogenase
HPS44_09515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPS44_09520	COG1252	NADH dehydrogenase
HPS44_09525	COG0284	orotidine-5'-phosphate decarboxylase activity
HPS44_09530	COG1546	Belongs to the CinA family
HPS44_09545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPS44_09550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPS44_09575	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HPS44_09580	COG3639	organic phosphonate transmembrane transporter activity
HPS44_09585	COG3639	organic phosphonate transmembrane transporter activity
HPS44_09600	COG0742	ribosomal rna small subunit methyltransferase
HPS44_09605	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPS44_09610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPS44_09615	COG3135	benzoate transporter
HPS44_09630	COG2814	Major facilitator Superfamily
HPS44_09650	COG4773	Receptor
HPS44_09655	COG4804	nuclease activity
HPS44_09660	COG0012	GTP binding
HPS44_09670	COG0193	aminoacyl-tRNA hydrolase activity
HPS44_09690	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPS44_09695	COG0840	transmembrane signaling receptor activity
HPS44_09710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPS44_09735	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPS44_09745	COG0204	Acyl-transferase
HPS44_09750	COG1368	sulfuric ester hydrolase activity
HPS44_09755	COG2186	Transcriptional regulator
HPS44_09760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS44_09770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_09780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS44_09790	COG2205	protein histidine kinase activity
HPS44_09795	COG0745	RESPONSE REGULATOR receiver
HPS44_09800	COG0277	FAD linked oxidase domain protein
HPS44_09815	COG0166	Belongs to the GPI family
HPS44_09820	COG0405	Gamma-glutamyltransferase
HPS44_09825	COG0438	transferase activity, transferring glycosyl groups
HPS44_09830	COG0438	transferase activity, transferring glycosyl groups
HPS44_09835	COG0438	transferase activity, transferring glycosyl groups
HPS44_09860	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPS44_09865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPS44_09895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_09915	COG0747	negative chemotaxis
HPS44_09920	COG0601	transmembrane transport
HPS44_09925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_09930	COG4172	Belongs to the ABC transporter superfamily
HPS44_09935	COG0154	amidase activity
HPS44_09975	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPS44_09975	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPS44_09980	COG0509	glycine decarboxylation via glycine cleavage system
HPS44_09985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPS44_10000	COG2081	HI0933 family
HPS44_10005	COG1982	Orn Lys Arg decarboxylase major
HPS44_10020	COG3706	GGDEF domain
HPS44_10030	COG0717	Belongs to the dCTP deaminase family
HPS44_10045	COG0489	protein tyrosine kinase activity
HPS44_10055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS44_10055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS44_10075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPS44_10075	COG2755	lipolytic protein G-D-S-L family
HPS44_10090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPS44_10095	COG2200	EAL domain
HPS44_10100	COG1595	DNA-templated transcription, initiation
HPS44_10110	COG4774	siderophore transport
HPS44_10130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_10135	COG1129	ABC transporter
HPS44_10135	COG0842	Transport permease protein
HPS44_10140	COG0842	Transport permease protein
HPS44_10150	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_10155	COG0583	DNA-binding transcription factor activity
HPS44_10160	COG0697	spore germination
HPS44_10170	COG1271	oxidase subunit
HPS44_10175	COG1294	oxidase, subunit
HPS44_10185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_10220	COG3258	Cytochrome c
HPS44_10230	COG0625	glutathione transferase activity
HPS44_10235	COG2986	histidine ammonia-lyase
HPS44_10240	COG1234	tRNA 3'-trailer cleavage
HPS44_10250	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPS44_10265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPS44_10290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPS44_10310	COG1595	DNA-templated transcription, initiation
HPS44_10315	COG3712	iron ion homeostasis
HPS44_10325	COG0165	Argininosuccinate lyase
HPS44_10330	COG2205	protein histidine kinase activity
HPS44_10335	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_10340	COG3246	L-lysine catabolic process to acetate
HPS44_10355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPS44_10360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS44_10365	COG0154	amidase activity
HPS44_10370	COG0372	Belongs to the citrate synthase family
HPS44_10375	COG4948	Mandelate Racemase Muconate Lactonizing
HPS44_10400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS44_10405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_10410	COG0583	DNA-binding transcription factor activity
HPS44_10415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPS44_10435	COG1652	LysM domain
HPS44_10440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPS44_10445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPS44_10460	COG0625	glutathione transferase activity
HPS44_10490	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_10540	COG1414	Transcriptional regulator
HPS44_10550	COG0800	Aldolase
HPS44_10555	COG4948	Mandelate Racemase Muconate Lactonizing
HPS44_10560	COG2271	Major facilitator Superfamily
HPS44_10565	COG1131	(ABC) transporter
HPS44_10580	COG4774	siderophore transport
HPS44_10585	COG2814	Major facilitator Superfamily
HPS44_10590	COG0326	Molecular chaperone. Has ATPase activity
HPS44_10600	COG2233	PERMEase
HPS44_10630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPS44_10685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPS44_10695	COG3657	addiction module killer protein
HPS44_10710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_10720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS44_10725	COG3246	L-lysine catabolic process to acetate
HPS44_10735	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_10845	COG2198	Histidine kinase
HPS44_10845	COG5002	protein histidine kinase activity
HPS44_10845	COG0784	Response regulator, receiver
HPS44_10875	COG0583	DNA-binding transcription factor activity
HPS44_10885	COG1695	Transcriptional regulator
HPS44_10900	COG0477	Major facilitator Superfamily
HPS44_10915	COG0277	FAD linked oxidase domain protein
HPS44_10925	COG3842	ATPase activity
HPS44_10930	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS44_10950	COG0628	permease
HPS44_10955	COG0583	DNA-binding transcription factor activity
HPS44_10960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_11010	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HPS44_11020	COG2186	Transcriptional regulator
HPS44_11030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPS44_11055	COG0410	ABC transporter
HPS44_11060	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_11065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPS44_11075	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPS44_11085	COG0583	DNA-binding transcription factor activity
HPS44_11090	COG0129	dihydroxy-acid dehydratase activity
HPS44_11100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS44_11105	COG0583	DNA-binding transcription factor activity
HPS44_11120	COG2200	EAL domain
HPS44_11125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPS44_11130	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPS44_11135	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_11140	COG2031	fatty acid transporter
HPS44_11145	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_11150	COG1414	Transcriptional regulator
HPS44_11160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS44_11165	COG4829	muconolactone delta-isomerase
HPS44_11175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS44_11195	COG0288	reversible hydration of carbon dioxide
HPS44_11200	COG1802	Transcriptional regulator
HPS44_11205	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_11215	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_11250	COG0625	glutathione transferase activity
HPS44_11265	COG0583	DNA-binding transcription factor activity
HPS44_11275	COG0583	DNA-binding transcription factor activity
HPS44_11280	COG0477	Major facilitator Superfamily
HPS44_11305	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_11325	COG1464	Belongs to the NlpA lipoprotein family
HPS44_11340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPS44_11345	COG2890	protein-(glutamine-N5) methyltransferase activity
HPS44_11350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPS44_11365	COG1280	lysine exporter protein (LysE YggA)
HPS44_11370	COG1522	sequence-specific DNA binding
HPS44_11390	COG3622	Belongs to the hyi family
HPS44_11410	COG0583	DNA-binding transcription factor activity
HPS44_11415	COG2186	Transcriptional regulator
HPS44_11420	COG3395	kinase activity
HPS44_11425	COG2084	Dehydrogenase
HPS44_11430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS44_11435	COG3622	Belongs to the hyi family
HPS44_11440	COG0235	Class ii aldolase
HPS44_11510	COG0142	geranyltranstransferase activity
HPS44_11515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPS44_11520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPS44_11525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPS44_11530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPS44_11545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPS44_11550	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPS44_11560	COG2186	Transcriptional regulator
HPS44_11565	COG3447	MASE1 domain protein
HPS44_11565	COG5001	Diguanylate cyclase
HPS44_11565	COG5002	protein histidine kinase activity
HPS44_11570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPS44_11575	COG0793	Belongs to the peptidase S41A family
HPS44_11580	COG4942	peptidase
HPS44_11585	COG0588	phosphoglycerate mutase activity
HPS44_11595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPS44_11600	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPS44_11605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPS44_11610	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_11620	COG1040	competence protein
HPS44_11625	COG2226	methyltransferase
HPS44_11630	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HPS44_11635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPS44_11640	COG0569	domain protein
HPS44_11645	COG2204	response regulator
HPS44_11650	COG5000	phosphorelay sensor kinase activity
HPS44_11660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPS44_11660	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPS44_11665	COG1280	lysine exporter protein (LysE YggA)
HPS44_11670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPS44_11680	COG1733	regulation of RNA biosynthetic process
HPS44_11700	COG0546	phosphoglycolate phosphatase activity
HPS44_11710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPS44_11715	COG0242	peptide deformylase activity
HPS44_11720	COG0758	DNA mediated transformation
HPS44_11735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_11740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_11745	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPS44_11750	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_11765	COG1238	metal cluster binding
HPS44_11770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPS44_11775	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_11790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPS44_11795	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPS44_11800	COG4988	ABC transporter
HPS44_11810	COG1294	oxidase, subunit
HPS44_11825	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HPS44_11835	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPS44_11850	COG1137	ATPase activity
HPS44_11855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPS44_11865	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HPS44_11870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_11885	COG1660	Displays ATPase and GTPase activities
HPS44_11895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPS44_11905	COG0792	nuclease activity
HPS44_11910	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPS44_11920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_11925	COG1464	Belongs to the NlpA lipoprotein family
HPS44_11930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPS44_11940	COG1309	transcriptional regulator
HPS44_11945	COG0471	metal ion transport
HPS44_11950	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPS44_11955	COG0772	Belongs to the SEDS family
HPS44_11960	COG0768	penicillin binding
HPS44_11970	COG1792	Involved in formation and maintenance of cell shape
HPS44_11975	COG1077	Cell shape determining protein MreB Mrl
HPS44_11980	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPS44_11985	COG0154	amidase activity
HPS44_11990	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPS44_12005	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPS44_12010	COG0708	Exodeoxyribonuclease III
HPS44_12015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPS44_12025	COG0583	DNA-binding transcription factor activity
HPS44_12040	COG0583	DNA-binding transcription factor activity
HPS44_12065	COG1764	response to oxidative stress
HPS44_12070	COG1846	Transcriptional regulator
HPS44_12130	COG0640	Transcriptional regulator
HPS44_12160	COG3189	MarR family transcriptional regulator
HPS44_12180	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_12185	COG0352	thiamine-phosphate diphosphorylase activity
HPS44_12185	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPS44_12185	COG0351	phosphomethylpyrimidine kinase
HPS44_12220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPS44_12225	COG0513	Belongs to the DEAD box helicase family
HPS44_12235	COG0617	tRNA 3'-terminal CCA addition
HPS44_12245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPS44_12250	COG2308	Evidence 4 Homologs of previously reported genes of
HPS44_12260	COG1305	Transglutaminase-like
HPS44_12280	COG1950	PFAM Membrane protein of
HPS44_12285	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HPS44_12290	COG0438	transferase activity, transferring glycosyl groups
HPS44_12305	COG0066	3-isopropylmalate dehydratase activity
HPS44_12320	COG0583	DNA-binding transcription factor activity
HPS44_12325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPS44_12365	COG0477	Major facilitator Superfamily
HPS44_12370	COG0154	amidase activity
HPS44_12375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPS44_12390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPS44_12400	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPS44_12405	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HPS44_12415	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPS44_12430	COG0735	belongs to the Fur family
HPS44_12435	COG0523	cobalamin synthesis protein
HPS44_12445	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPS44_12450	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPS44_12460	COG2096	Adenosyltransferase
HPS44_12465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPS44_12480	COG0321	lipoyl(octanoyl) transferase activity
HPS44_12485	COG2921	Belongs to the UPF0250 family
HPS44_12495	COG1686	Belongs to the peptidase S11 family
HPS44_12520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPS44_12530	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HPS44_12545	COG0859	PFAM glycosyl transferase family 9
HPS44_12570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPS44_12600	COG0438	transferase activity, transferring glycosyl groups
HPS44_12610	COG0367	asparagine synthase
HPS44_12630	COG1088	dTDP-glucose 4,6-dehydratase activity
HPS44_12635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPS44_12645	COG0367	asparagine synthase
HPS44_12680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPS44_12700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPS44_12720	COG0367	asparagine synthase
HPS44_12725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPS44_12740	COG2814	Major facilitator Superfamily
HPS44_12770	COG3568	Endonuclease Exonuclease Phosphatase
HPS44_12775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPS44_12800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS44_12815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_12820	COG1956	GAF domain-containing protein
HPS44_12825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_12850	COG2186	Transcriptional regulator
HPS44_12855	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPS44_12885	COG4106	trans-aconitate 2-methyltransferase activity
HPS44_12895	COG2814	Major facilitator Superfamily
HPS44_12905	COG0625	glutathione transferase activity
HPS44_12910	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPS44_12915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPS44_12920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPS44_12930	COG1965	Belongs to the frataxin family
HPS44_12940	COG0019	diaminopimelate decarboxylase activity
HPS44_12945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPS44_12950	COG1333	cytochrome c biogenesis protein
HPS44_12960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HPS44_12975	COG4232	protein-disulfide reductase activity
HPS44_12980	COG1324	tolerance protein
HPS44_12990	COG0203	ribosomal protein L17
HPS44_12995	COG0202	RNA polymerase activity
HPS44_13000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPS44_13005	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPS44_13010	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPS44_13015	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPS44_13020	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPS44_13025	COG0201	protein transport
HPS44_13030	COG0200	Binds to the 23S rRNA
HPS44_13035	COG1841	ribosomal large subunit assembly
HPS44_13040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPS44_13045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPS44_13050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPS44_13055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPS44_13060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPS44_13065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPS44_13070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPS44_13075	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPS44_13090	COG2169	Transcriptional regulator
HPS44_13090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPS44_13105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS44_13125	COG4177	L-phenylalanine transmembrane transporter activity
HPS44_13140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPS44_13145	COG0255	Belongs to the universal ribosomal protein uL29 family
HPS44_13150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPS44_13155	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPS44_13160	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPS44_13165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPS44_13170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPS44_13175	COG0089	rRNA binding
HPS44_13185	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPS44_13190	COG0051	transcription antitermination factor activity, RNA binding
HPS44_13195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPS44_13200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPS44_13205	COG0049	tRNA binding
HPS44_13210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HPS44_13215	COG0745	RESPONSE REGULATOR receiver
HPS44_13230	COG5002	protein histidine kinase activity
HPS44_13245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPS44_13250	COG0085	RNA polymerase activity
HPS44_13255	COG0222	ribosome binding
HPS44_13260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPS44_13265	COG0081	regulation of translation
HPS44_13270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPS44_13280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPS44_13290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPS44_13330	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS44_13335	COG3842	ATPase activity
HPS44_13345	COG1349	DNA-binding transcription factor activity
HPS44_13370	COG0583	DNA-binding transcription factor activity
HPS44_13375	COG0252	asparaginase activity
HPS44_13380	COG1475	DNA binding
HPS44_13390	COG1192	Involved in chromosome partitioning
HPS44_13395	COG0357	Ribosomal RNA small subunit methyltransferase G
HPS44_13400	COG0445	tRNA wobble uridine modification
HPS44_13405	COG1278	Cold shock
HPS44_13410	COG3180	Ammonia monooxygenase
HPS44_13415	COG0436	Aminotransferase
HPS44_13445	COG0038	chloride channel
HPS44_13455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPS44_13465	COG0601	transmembrane transport
HPS44_13470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_13475	COG0444	Belongs to the ABC transporter superfamily
HPS44_13480	COG4608	Belongs to the ABC transporter superfamily
HPS44_13485	COG1473	amidohydrolase
HPS44_13490	COG2175	clavaminate synthase activity
HPS44_13500	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPS44_13505	COG0753	catalase activity
HPS44_13515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HPS44_13520	COG0594	ribonuclease P activity
HPS44_13525	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPS44_13530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPS44_13535	COG0592	DNA-directed DNA polymerase activity
HPS44_13545	COG0583	DNA-binding transcription factor activity
HPS44_13570	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HPS44_13580	COG0583	DNA-binding transcription factor activity
HPS44_13585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_13590	COG0765	amino acid transport
HPS44_13595	COG0765	amino acid transport
HPS44_13600	COG1126	abc transporter atp-binding protein
HPS44_13640	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS44_13645	COG1177	transmembrane transport
HPS44_13700	COG1609	Transcriptional regulator
HPS44_13710	COG3842	ATPase activity
HPS44_13715	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS44_13720	COG1177	transmembrane transport
HPS44_13745	COG0251	oxidation-reduction process
HPS44_13785	COG0402	S-adenosylhomocysteine deaminase activity
HPS44_13805	COG1744	ABC transporter substrate-binding protein PnrA-like
HPS44_13815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPS44_13830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPS44_13845	COG2814	Major facilitator Superfamily
HPS44_13860	COG3781	membrane
HPS44_13865	COG1522	sequence-specific DNA binding
HPS44_13870	COG0028	Belongs to the TPP enzyme family
HPS44_13875	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_13880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_13905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPS44_13910	COG2922	Belongs to the Smg family
HPS44_13920	COG2358	TRAP transporter, solute receptor (TAXI family
HPS44_13940	COG0765	amino acid transport
HPS44_13945	COG0765	amino acid transport
HPS44_13950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_13955	COG3422	double-strand break repair
HPS44_13960	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_13965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPS44_14010	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPS44_14030	COG3339	Conserved Protein
HPS44_14065	COG2186	Transcriptional regulator
HPS44_14070	COG2814	Major facilitator Superfamily
HPS44_14085	COG1595	DNA-templated transcription, initiation
HPS44_14090	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_14105	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_14115	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_14150	COG2207	Transcriptional regulator
HPS44_14170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPS44_14175	COG0183	Belongs to the thiolase family
HPS44_14180	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HPS44_14185	COG1960	acyl-CoA dehydrogenase activity
HPS44_14190	COG1473	amidohydrolase
HPS44_14200	COG1742	UPF0060 membrane protein
HPS44_14215	COG1280	lysine exporter protein (LysE YggA)
HPS44_14250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPS44_14260	COG0018	arginyl-trna synthetase
HPS44_14275	COG0395	ABC-type sugar transport system, permease component
HPS44_14280	COG1175	transmembrane transport
HPS44_14285	COG1653	transport
HPS44_14290	COG3842	ATPase activity
HPS44_14295	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS44_14300	COG1609	Transcriptional regulator
HPS44_14310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS44_14325	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPS44_14345	COG0583	DNA-binding transcription factor activity
HPS44_14365	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HPS44_14370	COG1280	lysine exporter protein (LysE YggA)
HPS44_14375	COG0513	Belongs to the DEAD box helicase family
HPS44_14380	COG5339	Protein conserved in bacteria
HPS44_14385	COG5339	Protein conserved in bacteria
HPS44_14390	COG1228	amidohydrolase
HPS44_14400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_14410	COG0747	negative chemotaxis
HPS44_14415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPS44_14425	COG3708	Transcriptional regulator
HPS44_14425	COG2207	Transcriptional regulator
HPS44_14435	COG1104	cysteine desulfurase activity
HPS44_14445	COG0583	DNA-binding transcription factor activity
HPS44_14475	COG2969	positive regulation of protein catabolic process
HPS44_14480	COG0625	glutathione transferase activity
HPS44_14485	COG2857	Cytochrome c1
HPS44_14490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPS44_14495	COG0723	plastoquinol--plastocyanin reductase activity
HPS44_14500	COG1970	mechanosensitive ion channel activity
HPS44_14505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPS44_14510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS44_14525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPS44_14530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPS44_14535	COG0537	adenosine 5'-monophosphoramidase activity
HPS44_14540	COG0140	phosphoribosyl-ATP diphosphatase activity
HPS44_14550	COG0107	imidazoleglycerol-phosphate synthase activity
HPS44_14555	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPS44_14560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPS44_14565	COG0131	Imidazoleglycerol-phosphate dehydratase
HPS44_14570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPS44_14575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPS44_14580	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPS44_14585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPS44_14595	COG0842	Transport permease protein
HPS44_14600	COG1131	(ABC) transporter
HPS44_14610	COG2853	Lipoprotein
HPS44_14615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPS44_14620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPS44_14625	COG1127	ABC transporter
HPS44_14630	COG2070	2-Nitropropane dioxygenase
HPS44_14640	COG0477	Major facilitator Superfamily
HPS44_14655	COG0583	DNA-binding transcription factor activity
HPS44_14660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPS44_14665	COG0511	ligase activity, forming carbon-carbon bonds
HPS44_14680	COG1984	allophanate hydrolase subunit 2
HPS44_14695	COG0067	glutamate synthase
HPS44_14695	COG0069	glutamate synthase activity
HPS44_14695	COG0070	glutamate synthase
HPS44_14720	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS44_14740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS44_14770	COG1612	heme a metabolic process
HPS44_14780	COG1999	signal sequence binding
HPS44_14800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPS44_14805	COG2814	Major facilitator Superfamily
HPS44_14815	COG0438	transferase activity, transferring glycosyl groups
HPS44_14835	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HPS44_14840	COG1959	2 iron, 2 sulfur cluster binding
HPS44_14845	COG2814	Major facilitator Superfamily
HPS44_14860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPS44_14885	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPS44_14890	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPS44_14895	COG2814	Major facilitator Superfamily
HPS44_14900	COG0583	DNA-binding transcription factor activity
HPS44_14910	COG2423	ornithine cyclodeaminase activity
HPS44_14915	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HPS44_14920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPS44_14930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPS44_14940	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPS44_14945	COG0463	Glycosyl transferase, family 2
HPS44_14995	COG0737	Belongs to the 5'-nucleotidase family
HPS44_15010	COG2188	Transcriptional regulator
HPS44_15020	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPS44_15025	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPS44_15040	COG0840	transmembrane signaling receptor activity
HPS44_15045	COG2814	Major facilitator Superfamily
HPS44_15095	COG1802	Transcriptional regulator
HPS44_15105	COG3069	C4-dicarboxylate transmembrane transporter activity
HPS44_15110	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_15135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_15145	COG0747	negative chemotaxis
HPS44_15170	COG1464	Belongs to the NlpA lipoprotein family
HPS44_15175	COG0431	NADPH-dependent FMN reductase
HPS44_15180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS44_15185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS44_15190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_15205	COG2011	ABC-type metal ion transport system permease component
HPS44_15210	COG1464	Belongs to the NlpA lipoprotein family
HPS44_15215	COG1116	anion transmembrane transporter activity
HPS44_15220	COG3585	molybdate ion transport
HPS44_15225	COG3064	Membrane
HPS44_15250	COG1607	acyl-coa hydrolase
HPS44_15265	COG0437	4 iron, 4 sulfur cluster binding
HPS44_15270	COG2864	formate dehydrogenase
HPS44_15285	COG3276	selenocysteine insertion sequence binding
HPS44_15295	COG1216	Glycosyl transferase, family 2
HPS44_15300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_15305	COG1305	Transglutaminase-like
HPS44_15310	COG0709	Synthesizes selenophosphate from selenide and ATP
HPS44_15340	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_15345	COG3284	Transcriptional regulator
HPS44_15350	COG0134	indole-3-glycerol-phosphate synthase activity
HPS44_15355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPS44_15360	COG0512	Glutamine amidotransferase of anthranilate synthase
HPS44_15370	COG0546	phosphoglycolate phosphatase activity
HPS44_15375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPS44_15380	COG2967	ApaG domain
HPS44_15390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS44_15395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPS44_15405	COG0037	tRNA processing
HPS44_15420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS44_15435	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_15440	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_15455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPS44_15480	COG3473	Maleate cis-trans isomerase
HPS44_15485	COG0583	DNA-binding transcription factor activity
HPS44_15500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS44_15510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS44_15515	COG1024	Enoyl-CoA hydratase
HPS44_15530	COG0356	it plays a direct role in the translocation of protons across the membrane
HPS44_15545	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPS44_15550	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPS44_15555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPS44_15565	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPS44_15575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPS44_15580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPS44_15585	COG0210	DNA helicase
HPS44_15600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPS44_15615	COG2171	N-acyltransferase activity
HPS44_15625	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPS44_15635	COG4608	Belongs to the ABC transporter superfamily
HPS44_15640	COG0444	Belongs to the ABC transporter superfamily
HPS44_15650	COG0601	transmembrane transport
HPS44_15655	COG0747	negative chemotaxis
HPS44_15660	COG2988	succinylglutamate desuccinylase activity
HPS44_15670	COG0583	DNA-binding transcription factor activity
HPS44_15675	COG0747	negative chemotaxis
HPS44_15685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPS44_15690	COG1024	Enoyl-CoA hydratase
HPS44_15695	COG1024	Enoyl-CoA hydratase
HPS44_15705	COG1309	transcriptional regulator
HPS44_15720	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_15735	COG2814	Major facilitator Superfamily
HPS44_15750	COG1764	response to oxidative stress
HPS44_15755	COG0583	DNA-binding transcription factor activity
HPS44_15765	COG1595	DNA-templated transcription, initiation
HPS44_15770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPS44_15775	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_15790	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS44_15810	COG1129	ABC transporter
HPS44_15825	COG1802	Transcriptional regulator
HPS44_15835	COG0583	DNA-binding transcription factor activity
HPS44_15845	COG2988	succinylglutamate desuccinylase activity
HPS44_15855	COG2918	glutathione biosynthetic process
HPS44_15885	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPS44_15890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS44_15900	COG2721	sulfolactate sulfo-lyase activity
HPS44_15905	COG2721	sulfolactate sulfo-lyase activity
HPS44_15910	COG2188	Transcriptional regulator
HPS44_15915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS44_15920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS44_15920	COG2813	Specifically methylates the guanine in position
HPS44_15925	COG2223	nitrite transmembrane transporter activity
HPS44_15935	COG2860	membrane
HPS44_15940	COG1802	Transcriptional regulator
HPS44_15950	COG1984	allophanate hydrolase subunit 2
HPS44_15955	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPS44_15965	COG0583	DNA-binding transcription factor activity
HPS44_15980	COG4774	siderophore transport
HPS44_15985	COG3712	iron ion homeostasis
HPS44_15995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS44_16010	COG2132	Multicopper oxidase
HPS44_16035	COG0745	RESPONSE REGULATOR receiver
HPS44_16040	COG2226	methyltransferase
HPS44_16055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPS44_16065	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPS44_16075	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPS44_16080	COG0351	phosphomethylpyrimidine kinase
HPS44_16085	COG2022	thiamine diphosphate biosynthetic process
HPS44_16090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPS44_16095	COG4771	TonB-dependent receptor
HPS44_16105	COG2186	Transcriptional regulator
HPS44_16120	COG1063	alcohol dehydrogenase
HPS44_16130	COG0765	amino acid transport
HPS44_16135	COG1126	abc transporter atp-binding protein
HPS44_16140	COG4948	Mandelate Racemase Muconate Lactonizing
HPS44_16145	COG0246	Mannitol dehydrogenase
HPS44_16165	COG1194	a g-specific adenine glycosylase
HPS44_16185	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HPS44_16190	COG2177	Part of the ABC transporter FtsEX involved in
HPS44_16195	COG2884	Cell division ATP-binding protein ftsE
HPS44_16200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_16205	COG4597	amino acid ABC transporter
HPS44_16210	COG0765	amino acid transport
HPS44_16215	COG1126	abc transporter atp-binding protein
HPS44_16240	COG1129	ABC transporter
HPS44_16245	COG4177	L-phenylalanine transmembrane transporter activity
HPS44_16260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS44_16265	COG2081	HI0933 family
HPS44_16275	COG1605	Chorismate mutase
HPS44_16275	COG0077	Prephenate dehydratase
HPS44_16310	COG0477	Major facilitator Superfamily
HPS44_16320	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HPS44_16325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPS44_16345	COG0237	dephospho-CoA kinase activity
HPS44_16350	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPS44_16380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_16385	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS44_16400	COG3833	ABC-type maltose transport systems, permease component
HPS44_16405	COG1175	transmembrane transport
HPS44_16410	COG3842	ATPase activity
HPS44_16430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HPS44_16465	COG0410	ABC transporter
HPS44_16485	COG3706	GGDEF domain
HPS44_16505	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_16510	COG1024	Enoyl-CoA hydratase
HPS44_16550	COG4638	Rieske (2fe-2S)
HPS44_16555	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HPS44_16560	COG1335	isochorismatase
HPS44_16565	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_16575	COG0741	lytic transglycosylase activity
HPS44_16580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPS44_16585	COG0352	thiamine-phosphate diphosphorylase activity
HPS44_16600	COG1678	Uncharacterized ACR, COG1678
HPS44_16605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPS44_16615	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPS44_16635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS44_16640	COG0436	Aminotransferase
HPS44_16645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_16655	COG0765	amino acid transport
HPS44_16660	COG1126	abc transporter atp-binding protein
HPS44_16670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPS44_16680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPS44_16685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPS44_16695	COG3842	ATPase activity
HPS44_16700	COG1175	transmembrane transport
HPS44_16710	COG0642	Histidine kinase
HPS44_16720	COG0557	exoribonuclease II activity
HPS44_16725	COG3150	esterase
HPS44_16730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPS44_16735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_16740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPS44_16745	COG0511	ligase activity, forming carbon-carbon bonds
HPS44_16750	COG0439	Biotin carboxylase
HPS44_16755	COG2264	protein methyltransferase activity
HPS44_16765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPS44_16765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPS44_16790	COG1696	Membrane protein involved in D-alanine export
HPS44_16825	COG1522	sequence-specific DNA binding
HPS44_16830	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_16840	COG0583	DNA-binding transcription factor activity
HPS44_16855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPS44_16860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPS44_16860	COG1042	CoA-binding domain protein
HPS44_16860	COG0045	succinate-CoA ligase (ADP-forming) activity
HPS44_16865	COG1335	isochorismatase
HPS44_16870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_16875	COG1116	anion transmembrane transporter activity
HPS44_16890	COG3028	Belongs to the UPF0307 family
HPS44_16895	COG0312	modulator of DNA gyrase
HPS44_16900	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPS44_16910	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_16915	COG4177	L-phenylalanine transmembrane transporter activity
HPS44_16930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPS44_16935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPS44_16940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPS44_16950	COG0316	Belongs to the HesB IscA family
HPS44_16965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPS44_16975	COG1280	lysine exporter protein (LysE YggA)
HPS44_16980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPS44_16985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPS44_16995	COG1335	isochorismatase
HPS44_17000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPS44_17000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPS44_17015	COG2766	serine protein kinase
HPS44_17020	COG2718	Belongs to the UPF0229 family
HPS44_17025	COG2719	SpoVR family
HPS44_17035	COG0583	DNA-binding transcription factor activity
HPS44_17040	COG1942	4-Oxalocrotonate Tautomerase
HPS44_17050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPS44_17060	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_17105	COG4789	Type iii secretion
HPS44_17210	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPS44_17215	COG4790	Type iii secretion
HPS44_17220	COG4794	Type iii secretion
HPS44_17225	COG4791	protein targeting
HPS44_17230	COG4792	protein secretion
HPS44_17260	COG2770	Histidine kinase
HPS44_17260	COG2208	phosphoserine phosphatase activity
HPS44_17270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPS44_17275	COG2172	sigma factor antagonist activity
HPS44_17280	COG1366	Belongs to the anti-sigma-factor antagonist family
HPS44_17320	COG0741	lytic transglycosylase activity
HPS44_17320	COG1388	LysM domain
HPS44_17325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPS44_17330	COG2226	methyltransferase
HPS44_17335	COG0328	RNA-DNA hybrid ribonuclease activity
HPS44_17345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS44_17350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPS44_17365	COG1671	Belongs to the UPF0178 family
HPS44_17380	COG0786	glutamate:sodium symporter activity
HPS44_17390	COG0463	Glycosyl transferase, family 2
HPS44_17395	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPS44_17410	COG0583	DNA-binding transcription factor activity
HPS44_17430	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_17450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_17460	COG0583	DNA-binding transcription factor activity
HPS44_17470	COG1346	cytolysis
HPS44_17480	COG0697	spore germination
HPS44_17485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_17500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPS44_17510	COG1522	sequence-specific DNA binding
HPS44_17525	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPS44_17530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS44_17545	COG0823	Involved in the tonB-independent uptake of proteins
HPS44_17555	COG0848	biopolymer transport protein
HPS44_17560	COG0811	peptide transport
HPS44_17565	COG0824	Thioesterase
HPS44_17570	COG0442	prolyl-tRNA aminoacylation
HPS44_17600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS44_17615	COG2084	Dehydrogenase
HPS44_17620	COG0405	Gamma-glutamyltransferase
HPS44_17660	COG0129	dihydroxy-acid dehydratase activity
HPS44_17665	COG4654	Cytochrome c, class I
HPS44_17670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS44_17680	COG1522	sequence-specific DNA binding
HPS44_17720	COG0583	DNA-binding transcription factor activity
HPS44_17730	COG1473	amidohydrolase
HPS44_17735	COG0418	dihydroorotase activity
HPS44_17750	COG2001	Belongs to the MraZ family
HPS44_17755	COG0275	rRNA processing
HPS44_17760	COG3116	cell division
HPS44_17770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPS44_17775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPS44_17780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPS44_17790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPS44_17795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPS44_17800	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPS44_17805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPS44_17815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPS44_17820	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPS44_17830	COG0739	heme binding
HPS44_17835	COG0653	protein targeting
HPS44_17850	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_17855	COG0028	Belongs to the TPP enzyme family
HPS44_17865	COG0300	oxidoreductase activity
HPS44_17870	COG1522	sequence-specific DNA binding
HPS44_17885	COG2239	Acts as a magnesium transporter
HPS44_17895	COG2855	membrane
HPS44_17900	COG0583	DNA-binding transcription factor activity
HPS44_17905	COG1473	amidohydrolase
HPS44_17910	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_17915	COG0483	inositol monophosphate 1-phosphatase activity
HPS44_17920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_17920	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPS44_17925	COG1501	Belongs to the glycosyl hydrolase 31 family
HPS44_17930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPS44_17935	COG2011	ABC-type metal ion transport system permease component
HPS44_17995	COG0840	transmembrane signaling receptor activity
HPS44_18000	COG0583	DNA-binding transcription factor activity
HPS44_18010	COG0735	belongs to the Fur family
HPS44_18035	COG2818	Glycosylase
HPS44_18040	COG1368	sulfuric ester hydrolase activity
HPS44_18045	COG2982	Protein involved in outer membrane biogenesis
HPS44_18060	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_18090	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPS44_18120	COG3178	'Phosphotransferase
HPS44_18130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS44_18135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPS44_18140	COG1929	Belongs to the glycerate kinase type-1 family
HPS44_18145	COG0469	pyruvate kinase activity
HPS44_18150	COG0700	Nucleoside recognition
HPS44_18155	COG1960	acyl-CoA dehydrogenase activity
HPS44_18160	COG0242	peptide deformylase activity
HPS44_18170	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPS44_18180	COG0204	Acyl-transferase
HPS44_18185	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPS44_18190	COG0751	glycine-tRNA ligase activity
HPS44_18195	COG0752	glycyl-tRNA synthetase alpha subunit
HPS44_18200	COG1024	Enoyl-CoA hydratase
HPS44_18220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_18225	COG2030	dehydratase
HPS44_18230	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_18250	COG2070	2-Nitropropane dioxygenase
HPS44_18260	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_18265	COG0183	Belongs to the thiolase family
HPS44_18275	COG1960	acyl-CoA dehydrogenase activity
HPS44_18280	COG1960	acyl-CoA dehydrogenase activity
HPS44_18285	COG1024	Enoyl-CoA hydratase
HPS44_18295	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HPS44_18305	COG2301	Belongs to the HpcH HpaI aldolase family
HPS44_18310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPS44_18320	COG0617	tRNA 3'-terminal CCA addition
HPS44_18335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPS44_18345	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPS44_18350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPS44_18355	COG0586	Pfam SNARE associated Golgi protein
HPS44_18365	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPS44_18370	COG0802	atpase or kinase
HPS44_18375	COG0114	fumarate hydratase activity
HPS44_18385	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_18400	COG0531	amino acid
HPS44_18405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_18410	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_18415	COG1960	acyl-CoA dehydrogenase activity
HPS44_18420	COG0583	DNA-binding transcription factor activity
HPS44_18425	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS44_18445	COG2175	clavaminate synthase activity
HPS44_18455	COG0583	DNA-binding transcription factor activity
HPS44_18465	COG0579	oxidoreductase
HPS44_18475	COG0259	pyridoxamine-phosphate oxidase activity
HPS44_18490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_18495	COG0577	efflux transmembrane transporter activity
HPS44_18495	COG1136	(ABC) transporter
HPS44_18500	COG1538	Outer membrane efflux protein
HPS44_18505	COG0583	DNA-binding transcription factor activity
HPS44_18520	COG0577	efflux transmembrane transporter activity
HPS44_18520	COG1136	(ABC) transporter
HPS44_18555	COG0577	efflux transmembrane transporter activity
HPS44_18555	COG1136	(ABC) transporter
HPS44_18560	COG1136	(ABC) transporter
HPS44_18560	COG0577	efflux transmembrane transporter activity
HPS44_18570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_18575	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPS44_18610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPS44_18620	COG0800	Aldolase
HPS44_18635	COG0463	Glycosyl transferase, family 2
HPS44_18635	COG1216	Glycosyl transferase, family 2
HPS44_18660	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_18665	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HPS44_18685	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HPS44_18690	COG4638	Rieske (2fe-2S)
HPS44_18715	COG0747	negative chemotaxis
HPS44_18725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_18730	COG0444	Belongs to the ABC transporter superfamily
HPS44_18735	COG4608	Belongs to the ABC transporter superfamily
HPS44_18755	COG2746	aminoglycoside 3-N-acetyltransferase activity
HPS44_18760	COG0488	(ABC) transporter
HPS44_18785	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPS44_18790	COG2894	cell division
HPS44_18795	COG0850	regulation of cytokinetic process
HPS44_18800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPS44_18810	COG1294	oxidase, subunit
HPS44_18815	COG0514	ATP-dependent DNA helicase (RecQ)
HPS44_18825	COG0745	RESPONSE REGULATOR receiver
HPS44_18830	COG4191	Histidine kinase
HPS44_18835	COG2255	four-way junction helicase activity
HPS44_18845	COG1090	epimerase
HPS44_18850	COG0632	four-way junction helicase activity
HPS44_18855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPS44_18875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS44_18885	COG0006	proline dipeptidase activity
HPS44_18900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPS44_18905	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_18920	COG4783	chaperone-mediated protein folding
HPS44_18960	COG2814	Major facilitator Superfamily
HPS44_18965	COG4771	TonB-dependent receptor
HPS44_18975	COG0513	Belongs to the DEAD box helicase family
HPS44_18990	COG1546	Belongs to the CinA family
HPS44_18990	COG1058	Belongs to the CinA family
HPS44_18995	COG1414	Transcriptional regulator
HPS44_19010	COG0167	dihydroorotate dehydrogenase activity
HPS44_19015	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPS44_19020	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPS44_19110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPS44_19115	COG0735	belongs to the Fur family
HPS44_19120	COG0497	DNA recombination
HPS44_19130	COG1420	regulation of RNA biosynthetic process
HPS44_19135	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPS44_19145	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPS44_19155	COG0443	Heat shock 70 kDa protein
HPS44_19160	COG0484	heat shock protein binding
HPS44_19170	COG0612	Peptidase, M16
HPS44_19195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPS44_19230	COG0840	transmembrane signaling receptor activity
HPS44_19235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_19250	COG0745	RESPONSE REGULATOR receiver
HPS44_19255	COG2205	protein histidine kinase activity
HPS44_19260	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HPS44_19265	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HPS44_19270	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HPS44_19285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPS44_19295	COG1193	negative regulation of DNA recombination
HPS44_19300	COG0492	ferredoxin-NADP+ reductase activity
HPS44_19305	COG1674	ftsk spoiiie
HPS44_19310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPS44_19315	COG0251	oxidation-reduction process
HPS44_19320	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS44_19325	COG0517	IMP dehydrogenase activity
HPS44_19325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPS44_19345	COG0601	transmembrane transport
HPS44_19360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPS44_19365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPS44_19370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPS44_19415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_19425	COG4774	siderophore transport
HPS44_19430	COG4607	ABC-type enterochelin transport system periplasmic component
HPS44_19435	COG4604	ABC transporter, ATP-binding protein
HPS44_19440	COG4605	iron ion homeostasis
HPS44_19445	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS44_19475	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_19480	COG3022	response to hydroperoxide
HPS44_19485	COG1289	transmembrane transporter activity
HPS44_19490	COG0028	Belongs to the TPP enzyme family
HPS44_19495	COG0440	acetolactate synthase activity
HPS44_19500	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPS44_19505	COG1183	phosphatidylcholine synthase activity
HPS44_19515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPS44_19520	COG1185	polyribonucleotide nucleotidyltransferase activity
HPS44_19530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPS44_19540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPS44_19550	COG2207	Transcriptional regulator
HPS44_19575	COG0149	triose-phosphate isomerase activity
HPS44_19580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPS44_19595	COG3047	cAMP biosynthetic process
HPS44_19595	COG2885	chlorophyll binding
HPS44_19620	COG0840	transmembrane signaling receptor activity
HPS44_19640	COG1910	domain protein
HPS44_19660	COG1595	DNA-templated transcription, initiation
HPS44_19665	COG3712	iron ion homeostasis
HPS44_19680	COG1595	DNA-templated transcription, initiation
HPS44_19700	COG0642	Histidine kinase
HPS44_19710	COG2851	Citrate transporter
HPS44_19715	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_19735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPS44_19740	COG0784	Response regulator, receiver
HPS44_19740	COG4191	Histidine kinase
HPS44_19755	COG3604	Transcriptional regulator
HPS44_19760	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HPS44_19765	COG3813	Protein conserved in bacteria
HPS44_19770	COG2354	Protein conserved in bacteria
HPS44_19775	COG4772	TonB-dependent receptor
HPS44_19780	COG1522	sequence-specific DNA binding
HPS44_19800	COG4172	Belongs to the ABC transporter superfamily
HPS44_19810	COG0747	negative chemotaxis
HPS44_19830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS44_19845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPS44_19850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_19855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS44_19875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS44_19885	COG1309	transcriptional regulator
HPS44_19890	COG0583	DNA-binding transcription factor activity
HPS44_19910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS44_19935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_19940	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS44_19945	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS44_19950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS44_19955	COG0649	NAD binding
HPS44_19960	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HPS44_19970	COG1034	ATP synthesis coupled electron transport
HPS44_19975	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HPS44_19980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS44_19990	COG0713	ATP synthesis coupled electron transport
HPS44_20005	COG1007	ATP synthesis coupled electron transport
HPS44_20015	COG4774	siderophore transport
HPS44_20020	COG0560	Phosphoserine phosphatase
HPS44_20025	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPS44_20030	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPS44_20035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPS44_20045	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS44_20050	COG0450	alkyl hydroperoxide reductase
HPS44_20055	COG2205	protein histidine kinase activity
HPS44_20060	COG0745	RESPONSE REGULATOR receiver
HPS44_20065	COG1214	PFAM Peptidase M22, glycoprotease
HPS44_20070	COG1573	uracil-dna glycosylase
HPS44_20075	COG0477	Major facilitator Superfamily
HPS44_20080	COG1196	nuclear chromosome segregation
HPS44_20090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPS44_20095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS44_20105	COG2917	probably involved in intracellular septation
HPS44_20110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS44_20115	COG1122	ATPase activity
HPS44_20120	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPS44_20125	COG1268	BioY protein
HPS44_20160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPS44_20195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPS44_20200	COG2878	Part of a membrane complex involved in electron transport
HPS44_20215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPS44_20220	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPS44_20225	COG0251	oxidation-reduction process
HPS44_20235	COG3228	Belongs to the MtfA family
HPS44_20240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPS44_20250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS44_20260	COG0159	tryptophan synthase activity
HPS44_20265	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPS44_20270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HPS44_20275	COG1530	ribonuclease E activity
HPS44_20280	COG0564	pseudouridine synthase activity
HPS44_20285	COG0546	phosphoglycolate phosphatase activity
HPS44_20290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPS44_20295	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HPS44_20310	COG0424	maF-like protein
HPS44_20320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPS44_20330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS44_20335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPS44_20345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPS44_20350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPS44_20375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS44_20380	COG0481	GTPase activity
HPS44_20385	COG0681	Belongs to the peptidase S26 family
HPS44_20390	COG0571	ribonuclease III activity
HPS44_20395	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPS44_20400	COG1381	Involved in DNA repair and RecF pathway recombination
HPS44_20450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPS44_20475	COG0583	DNA-binding transcription factor activity
HPS44_20485	COG0791	NLP P60 protein
HPS44_20495	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HPS44_20505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPS44_20510	COG0697	spore germination
HPS44_20515	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPS44_20565	COG2153	protein acetylation
HPS44_20575	COG1446	asparaginase
HPS44_20580	COG4172	Belongs to the ABC transporter superfamily
HPS44_20585	COG0747	negative chemotaxis
HPS44_20620	COG0504	CTP synthase activity
HPS44_20630	COG0148	phosphopyruvate hydratase activity
HPS44_20645	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPS44_20655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPS44_20710	COG0039	L-malate dehydrogenase activity
HPS44_20715	COG2188	Transcriptional regulator
HPS44_20720	COG2009	succinate dehydrogenase
HPS44_20725	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPS44_20730	COG1053	succinate dehydrogenase
HPS44_20735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPS44_20740	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPS44_20745	COG0372	Belongs to the citrate synthase family
HPS44_20760	COG0280	phosphate acetyltransferase
HPS44_20760	COG0281	malic enzyme
HPS44_20770	COG1297	OPT oligopeptide transporter protein
HPS44_20775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS44_20790	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HPS44_20795	COG1522	sequence-specific DNA binding
HPS44_20800	COG0567	Dehydrogenase, E1 component
HPS44_20805	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPS44_20810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPS44_20815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPS44_20820	COG1595	DNA-templated transcription, initiation
HPS44_20825	COG3712	iron ion homeostasis
HPS44_20830	COG4774	siderophore transport
HPS44_20865	COG2183	response to ionizing radiation
HPS44_20870	COG1199	ATP-dependent helicase activity
HPS44_20880	COG0564	pseudouridine synthase activity
HPS44_20890	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPS44_20895	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_20900	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HPS44_20925	COG2831	hemolysin activation secretion protein
HPS44_20955	COG2823	Periplasmic or secreted lipoprotein
HPS44_20965	COG3237	CsbD-like
HPS44_20970	COG0189	ligase activity
HPS44_20970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPS44_20975	COG0189	ligase activity
HPS44_20975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPS44_20980	COG1132	(ABC) transporter
HPS44_20995	COG2833	Protein of unknown function (DUF455)
HPS44_21000	COG2258	MOSC domain
HPS44_21005	COG2951	lytic endotransglycosylase activity
HPS44_21020	COG1960	acyl-CoA dehydrogenase activity
HPS44_21030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPS44_21040	COG1696	Membrane protein involved in D-alanine export
HPS44_21060	COG1215	transferase activity, transferring glycosyl groups
HPS44_21070	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPS44_21095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPS44_21110	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPS44_21120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPS44_21130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HPS44_21135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPS44_21155	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPS44_21160	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPS44_21165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS44_21195	COG2951	lytic endotransglycosylase activity
HPS44_21200	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPS44_21225	COG2985	domain, Protein
HPS44_21230	COG1960	acyl-CoA dehydrogenase activity
HPS44_21235	COG0450	alkyl hydroperoxide reductase
HPS44_21245	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HPS44_21250	COG4208	sulfate ABC transporter
HPS44_21260	COG0175	sulfate reduction
HPS44_21290	COG0335	large ribosomal subunit rRNA binding
HPS44_21295	COG0494	nUDIX hydrolase
HPS44_21300	COG1162	GTPase activity
HPS44_21305	COG0501	Belongs to the peptidase M48B family
HPS44_21310	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPS44_21315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPS44_21320	COG3327	negative regulation of DNA-templated transcription, initiation
HPS44_21325	COG3396	Phenylacetate-CoA oxygenase
HPS44_21330	COG3460	Phenylacetate-CoA oxygenase
HPS44_21335	COG3396	Phenylacetate-CoA oxygenase
HPS44_21340	COG2151	metal-sulfur cluster biosynthetic enzyme
HPS44_21345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPS44_21350	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_21355	COG1024	Enoyl-CoA hydratase
HPS44_21360	COG2050	protein possibly involved in aromatic compounds catabolism
HPS44_21370	COG0534	Mate efflux family protein
HPS44_21385	COG3483	tryptophan 2,3-dioxygenase activity
HPS44_21390	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HPS44_21395	COG2003	Belongs to the UPF0758 family
HPS44_21405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPS44_21410	COG0625	glutathione transferase activity
HPS44_21415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS44_21440	COG0523	cobalamin synthesis protein
HPS44_21445	COG0523	cobalamin synthesis protein
HPS44_21450	COG0583	DNA-binding transcription factor activity
HPS44_21465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HPS44_21470	COG1187	pseudouridine synthase activity
HPS44_21475	COG0779	Required for maturation of 30S ribosomal subunits
HPS44_21480	COG2251	uridine kinase activity
HPS44_21480	COG0195	Participates in both transcription termination and antitermination
HPS44_21485	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPS44_21490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPS44_21495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPS44_21520	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_21525	COG1473	amidohydrolase
HPS44_21530	COG1611	Belongs to the LOG family
HPS44_21545	COG0412	Dienelactone hydrolase
HPS44_21555	COG1760	l-serine dehydratase
HPS44_21560	COG0501	Belongs to the peptidase M48B family
HPS44_21580	COG0583	DNA-binding transcription factor activity
HPS44_21585	COG3842	ATPase activity
HPS44_21595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPS44_21600	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS44_21620	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_21630	COG1722	exodeoxyribonuclease VII activity
HPS44_21635	COG0142	geranyltranstransferase activity
HPS44_21645	COG1469	GTP cyclohydrolase I activity
HPS44_21650	COG3739	integral membrane protein
HPS44_21655	COG0360	Binds together with S18 to 16S ribosomal RNA
HPS44_21660	COG2965	DNA replication, synthesis of RNA primer
HPS44_21665	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPS44_21670	COG0359	binds to the 23S rRNA
HPS44_21680	COG0305	Participates in initiation and elongation during chromosome replication
HPS44_21690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPS44_21725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_21775	COG0540	Belongs to the ATCase OTCase family
HPS44_21800	COG0642	Histidine kinase
HPS44_21810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPS44_21815	COG2137	regulation of response to DNA damage stimulus
HPS44_21840	COG0045	succinate-CoA ligase (ADP-forming) activity
HPS44_21845	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPS44_21850	COG0861	Integral membrane protein TerC family
HPS44_21855	COG0861	Integral membrane protein TerC family
HPS44_21860	COG0181	hydroxymethylbilane synthase activity
HPS44_21880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPS44_21890	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_21920	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_21940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPS44_21945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPS44_21955	COG0436	Aminotransferase
HPS44_21975	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HPS44_21980	COG0308	aminopeptidase N
HPS44_21995	COG0312	modulator of DNA gyrase
HPS44_22000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPS44_22005	COG0277	FAD linked oxidase domain protein
HPS44_22010	COG0277	FAD linked oxidase domain protein
HPS44_22015	COG0277	FAD linked oxidase domain protein
HPS44_22020	COG0247	lactate metabolic process
HPS44_22050	COG0583	DNA-binding transcription factor activity
HPS44_22055	COG0482	sulfurtransferase activity
HPS44_22060	COG0730	response to heat
HPS44_22065	COG0625	glutathione transferase activity
HPS44_22075	COG3909	cytochrome
HPS44_22115	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HPS44_22225	COG0697	spore germination
HPS44_22260	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HPS44_22270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS44_22275	COG0069	glutamate synthase activity
HPS44_22285	COG2391	methyltransferase activity
HPS44_22290	COG0679	Auxin Efflux Carrier
HPS44_22320	COG0557	exoribonuclease II activity
HPS44_22325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPS44_22335	COG3128	pkhd-type hydroxylase
HPS44_22340	COG0776	regulation of translation
HPS44_22365	COG0745	RESPONSE REGULATOR receiver
HPS44_22370	COG0642	Histidine kinase
HPS44_22375	COG3158	transport of potassium into the cell
HPS44_22385	COG0137	argininosuccinate synthase activity
HPS44_22390	COG0583	DNA-binding transcription factor activity
HPS44_22395	COG3618	amidohydrolase
HPS44_22415	COG0596	Alpha beta hydrolase
HPS44_22415	COG2945	thiolester hydrolase activity
HPS44_22420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPS44_22425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPS44_22445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_22450	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPS44_22460	COG3642	lipopolysaccharide core region biosynthetic process
HPS44_22470	COG3842	ATPase activity
HPS44_22475	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS44_22480	COG1177	transmembrane transport
HPS44_22500	COG1322	Protein conserved in bacteria
HPS44_22510	COG1960	acyl-CoA dehydrogenase activity
HPS44_22520	COG0704	Plays a role in the regulation of phosphate uptake
HPS44_22530	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPS44_22535	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPS44_22535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPS44_22540	COG1643	Atp-dependent helicase
HPS44_22545	COG0395	ABC-type sugar transport system, permease component
HPS44_22550	COG1116	anion transmembrane transporter activity
HPS44_22565	COG0438	transferase activity, transferring glycosyl groups
HPS44_22570	COG0726	polysaccharide deacetylase
HPS44_22585	COG0726	polysaccharide deacetylase
HPS44_22610	COG1132	(ABC) transporter
HPS44_22615	COG0475	glutathione-regulated potassium exporter activity
HPS44_22615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPS44_22625	COG2203	Gaf domain
HPS44_22625	COG3706	GGDEF domain
HPS44_22625	COG4251	negative regulation of phosphorylation
HPS44_22625	COG5001	Diguanylate cyclase
HPS44_22635	COG1530	ribonuclease E activity
HPS44_22665	COG2204	response regulator
HPS44_22670	COG4191	Histidine kinase
HPS44_22675	COG1301	dicarboxylic acid transport
HPS44_22685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPS44_22690	COG0799	negative regulation of ribosome biogenesis
HPS44_22695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPS44_22705	COG0151	Belongs to the GarS family
HPS44_22710	COG0217	transcriptional regulatory protein
HPS44_22715	COG0433	COG0433 Predicted ATPase
HPS44_22720	COG0473	3-isopropylmalate dehydrogenase activity
HPS44_22730	COG2814	Major facilitator Superfamily
HPS44_22735	COG1566	PFAM secretion protein HlyD family protein
HPS44_22745	COG1846	Transcriptional regulator
HPS44_22775	COG3391	amine dehydrogenase activity
HPS44_22785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPS44_22805	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPS44_22810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPS44_22820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPS44_22845	COG1309	transcriptional regulator
HPS44_22850	COG2311	Membrane
HPS44_22855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPS44_22880	COG0662	Cupin 2, conserved barrel domain protein
HPS44_22885	COG5285	phytanoyl-CoA dioxygenase
HPS44_22890	COG3217	Mosc domain protein beta barrel domain protein
HPS44_22890	COG0633	Ferredoxin
HPS44_22895	COG2076	Multidrug Resistance protein
HPS44_22910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_22925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPS44_22930	COG0425	Belongs to the sulfur carrier protein TusA family
HPS44_22940	COG0228	four-way junction DNA binding
HPS44_22950	COG0336	Belongs to the RNA methyltransferase TrmD family
HPS44_22955	COG1396	sequence-specific DNA binding
HPS44_22960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_22965	COG0765	amino acid transport
HPS44_22975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_22980	COG0525	valine-tRNA ligase activity
HPS44_22985	COG0105	UTP biosynthetic process
HPS44_22990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPS44_23010	COG2976	Protein conserved in bacteria
HPS44_23015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPS44_23020	COG1160	GTP binding
HPS44_23025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPS44_23030	COG1923	regulation of RNA biosynthetic process
HPS44_23035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPS44_23040	COG0330	HflC and HflK could
HPS44_23045	COG0330	HflC and HflK could
HPS44_23050	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HPS44_23055	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPS44_23060	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPS44_23065	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPS44_23085	COG0438	transferase activity, transferring glycosyl groups
HPS44_23125	COG4964	Belongs to the GSP D family
HPS44_23155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPS44_23165	COG1295	ribonuclease BN
HPS44_23175	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPS44_23200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPS44_23290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_23295	COG2274	protein secretion by the type I secretion system
HPS44_23305	COG1538	Outer membrane efflux protein
HPS44_23325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPS44_23335	COG0101	tRNA pseudouridine synthase activity
HPS44_23340	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPS44_23365	COG0596	Alpha beta hydrolase
HPS44_23395	COG0129	dihydroxy-acid dehydratase activity
HPS44_23400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_23405	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS44_23410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPS44_23415	COG1609	Transcriptional regulator
HPS44_23435	COG4172	Belongs to the ABC transporter superfamily
HPS44_23440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_23445	COG0601	transmembrane transport
HPS44_23455	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_23485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPS44_23490	COG2197	response regulator
HPS44_23500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPS44_23505	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPS44_23520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPS44_23525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPS44_23530	COG0004	ammonium transporteR
HPS44_23535	COG0347	Belongs to the P(II) protein family
HPS44_23545	COG2960	long-chain fatty acid transporting porin activity
HPS44_23555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPS44_23560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPS44_23565	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPS44_23570	COG0072	phenylalanine-tRNA ligase activity
HPS44_23570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS44_23625	COG0384	phenazine biosynthesis protein PhzF
HPS44_23630	COG0456	acetyltransferase
HPS44_23665	COG1522	sequence-specific DNA binding
HPS44_23695	COG0583	DNA-binding transcription factor activity
HPS44_23700	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_23725	COG1116	anion transmembrane transporter activity
HPS44_23755	COG5265	(ABC) transporter
HPS44_23760	COG0656	L-ascorbic acid biosynthetic process
HPS44_23775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPS44_23785	COG1917	Cupin 2, conserved barrel domain protein
HPS44_23785	COG4977	sequence-specific DNA binding
HPS44_23790	COG2223	nitrite transmembrane transporter activity
HPS44_23800	COG1215	transferase activity, transferring glycosyl groups
HPS44_23805	COG1649	PFAM Uncharacterised BCR, COG1649
HPS44_23805	COG0726	polysaccharide deacetylase
HPS44_23810	COG0457	Tetratricopeptide repeat
HPS44_23815	COG3706	GGDEF domain
HPS44_23840	COG1610	YqeY-like protein
HPS44_23850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPS44_23855	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_23865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPS44_23905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPS44_23915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPS44_23920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPS44_23945	COG1959	2 iron, 2 sulfur cluster binding
HPS44_23950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_23955	COG0697	spore germination
HPS44_23960	COG0506	proline dehydrogenase activity
HPS44_23980	COG0583	DNA-binding transcription factor activity
HPS44_23985	COG2814	Major facilitator Superfamily
HPS44_24000	COG0625	glutathione transferase activity
HPS44_24015	COG2814	Major facilitator Superfamily
HPS44_24020	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HPS44_24035	COG1960	acyl-CoA dehydrogenase activity
HPS44_24040	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_24065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPS44_24080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPS44_24090	COG3245	cytochrome
HPS44_24095	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPS44_24110	COG1280	lysine exporter protein (LysE YggA)
HPS44_24125	COG0697	spore germination
HPS44_24130	COG0697	spore germination
HPS44_24145	COG0534	Mate efflux family protein
HPS44_24150	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPS44_24155	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_24165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPS44_24170	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HPS44_24180	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_24215	COG2207	Transcriptional regulator
HPS44_24230	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_24235	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_24240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS44_24245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS44_24255	COG1304	FMN binding
HPS44_24295	COG3088	subunit of a heme lyase
HPS44_24300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_24310	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPS44_24330	COG4133	protoheme IX ABC transporter activity
HPS44_24350	COG3381	protein complex oligomerization
HPS44_24370	COG4235	cytochrome complex assembly
HPS44_24380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_24390	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPS44_24410	COG4133	protoheme IX ABC transporter activity
HPS44_24415	COG3005	denitrification pathway
HPS44_24420	COG3043	anaerobic respiration
HPS44_24425	COG0243	molybdopterin cofactor binding
HPS44_24440	COG3246	L-lysine catabolic process to acetate
HPS44_24445	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_24450	COG0583	DNA-binding transcription factor activity
HPS44_24460	COG0129	dihydroxy-acid dehydratase activity
HPS44_24465	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_24470	COG5001	Diguanylate cyclase
HPS44_24475	COG1024	Enoyl-CoA hydratase
HPS44_24520	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HPS44_24525	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_24530	COG0583	DNA-binding transcription factor activity
HPS44_24535	COG2610	gluconate transmembrane transporter activity
HPS44_24575	COG0235	Class ii aldolase
HPS44_24580	COG0477	Major facilitator Superfamily
HPS44_24595	COG2188	Transcriptional regulator
HPS44_24600	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_24640	COG1280	lysine exporter protein (LysE YggA)
HPS44_24645	COG5265	(ABC) transporter
HPS44_24655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_24670	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_24675	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_24710	COG0583	DNA-binding transcription factor activity
HPS44_24720	COG0583	DNA-binding transcription factor activity
HPS44_24730	COG0583	DNA-binding transcription factor activity
HPS44_24760	COG2814	Major facilitator Superfamily
HPS44_24765	COG0154	amidase activity
HPS44_24815	COG2070	2-Nitropropane dioxygenase
HPS44_24850	COG3657	addiction module killer protein
HPS44_24870	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_24875	COG0307	riboflavin synthase, alpha
HPS44_24885	COG2271	Major facilitator Superfamily
HPS44_24895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPS44_24905	COG0789	Transcriptional regulator
HPS44_24930	COG4774	siderophore transport
HPS44_24940	COG0022	dehydrogenase e1 component
HPS44_24960	COG1724	mRNA binding
HPS44_24965	COG1598	PFAM Uncharacterised protein family UPF0150
HPS44_24970	COG0165	Argininosuccinate lyase
HPS44_24975	COG0668	transmembrane transport
HPS44_25045	COG2165	general secretion pathway protein
HPS44_25075	COG0583	DNA-binding transcription factor activity
HPS44_25085	COG0747	negative chemotaxis
HPS44_25090	COG0601	transmembrane transport
HPS44_25100	COG4172	Belongs to the ABC transporter superfamily
HPS44_25105	COG4681	YaeQ
HPS44_25120	COG0477	Major facilitator Superfamily
HPS44_25125	COG3161	chorismate lyase activity
HPS44_25130	COG1187	pseudouridine synthase activity
HPS44_25135	COG0583	DNA-binding transcription factor activity
HPS44_25160	COG1999	signal sequence binding
HPS44_25170	COG0339	signal peptide processing
HPS44_25175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPS44_25180	COG4566	intracellular signal transduction
HPS44_25190	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPS44_25195	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPS44_25200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPS44_25210	COG0583	DNA-binding transcription factor activity
HPS44_25255	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HPS44_25270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HPS44_25285	COG1191	sigma factor activity
HPS44_25305	COG1360	Flagellar Motor Protein
HPS44_25310	COG0745	RESPONSE REGULATOR receiver
HPS44_25320	COG0835	chemotaxis
HPS44_25325	COG0840	transmembrane signaling receptor activity
HPS44_25330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPS44_25335	COG2201	protein-glutamate methylesterase activity
HPS44_25340	COG0745	RESPONSE REGULATOR receiver
HPS44_25345	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPS44_25350	COG0840	transmembrane signaling receptor activity
HPS44_25375	COG2747	anti-sigma28 factor FlgM
HPS44_25385	COG1815	bacterial-type flagellum-dependent cell motility
HPS44_25390	COG1558	bacterial-type flagellum-dependent cell motility
HPS44_25405	COG4787	bacterial-type flagellum-dependent cell motility
HPS44_25440	COG0840	transmembrane signaling receptor activity
HPS44_25445	COG0840	transmembrane signaling receptor activity
HPS44_25455	COG0840	transmembrane signaling receptor activity
HPS44_25460	COG0840	transmembrane signaling receptor activity
HPS44_25495	COG1580	Controls the rotational direction of flagella during chemotaxis
HPS44_25520	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPS44_25525	COG1766	The M ring may be actively involved in energy transduction
HPS44_25530	COG1677	Flagellar hook-basal body complex protein FliE
HPS44_25540	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPS44_25560	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPS44_25565	COG1334	flagellar protein FlaG
HPS44_25570	COG1414	Transcriptional regulator
HPS44_25580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_25595	COG0285	dihydrofolate synthase activity
HPS44_25615	COG1451	nucleotide metabolic process
HPS44_25620	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPS44_25630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPS44_25635	COG0024	Methionine aminopeptidase
HPS44_25645	COG0052	Belongs to the universal ribosomal protein uS2 family
HPS44_25650	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPS44_25655	COG0528	UMP kinase activity
HPS44_25660	COG0233	cytoplasmic translational termination
HPS44_25665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPS44_25680	COG0750	zinc metalloprotease
HPS44_25685	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPS44_25690	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPS44_25695	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPS44_25700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPS44_25715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPS44_25720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPS44_25755	COG2169	Transcriptional regulator
HPS44_25755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPS44_25760	COG0519	Catalyzes the synthesis of GMP from XMP
HPS44_25760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPS44_25780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPS44_25785	COG2867	negative regulation of translational initiation
HPS44_25790	COG2914	Belongs to the UPF0125 (RnfH) family
HPS44_25800	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_25800	COG1024	Enoyl-CoA hydratase
HPS44_25825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPS44_25830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPS44_25835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPS44_25840	COG0084	hydrolase, TatD family'
HPS44_25855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_25865	COG1126	abc transporter atp-binding protein
HPS44_25870	COG0010	Belongs to the arginase family
HPS44_25880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPS44_25890	COG0095	Lipoate-protein ligase
HPS44_25905	COG0625	glutathione transferase activity
HPS44_25915	COG1522	sequence-specific DNA binding
HPS44_25920	COG0386	Belongs to the glutathione peroxidase family
HPS44_25925	COG2814	Major facilitator Superfamily
HPS44_25945	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPS44_25955	COG0840	transmembrane signaling receptor activity
HPS44_25965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_26000	COG1902	pentaerythritol trinitrate reductase activity
HPS44_26030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPS44_26045	COG0842	Transport permease protein
HPS44_26050	COG1131	(ABC) transporter
HPS44_26060	COG2130	NADP-dependent
HPS44_26085	COG3842	ATPase activity
HPS44_26090	COG3842	ATPase activity
HPS44_26100	COG0395	ABC-type sugar transport system, permease component
HPS44_26140	COG0346	lactoylglutathione lyase activity
HPS44_26145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_26165	COG3634	alkyl hydroperoxide reductase activity
HPS44_26170	COG1959	2 iron, 2 sulfur cluster binding
HPS44_26180	COG0583	DNA-binding transcription factor activity
HPS44_26185	COG1960	acyl-CoA dehydrogenase activity
HPS44_26220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_26225	COG0420	3'-5' exonuclease activity
HPS44_26255	COG2111	Na H antiporter
HPS44_26255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPS44_26260	COG1006	Multisubunit Na H antiporter MnhC subunit
HPS44_26265	COG0651	ATP synthesis coupled electron transport
HPS44_26270	COG1863	multisubunit Na H antiporter MnhE subunit
HPS44_26275	COG2212	antiporter activity
HPS44_26280	COG1320	monovalent cation:proton antiporter activity
HPS44_26300	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPS44_26305	COG0488	(ABC) transporter
HPS44_26340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_26345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS44_26355	COG2252	PERMEase
HPS44_26365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPS44_26375	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPS44_26400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPS44_26405	COG0789	Transcriptional regulator
HPS44_26420	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPS44_26420	COG0678	peroxiredoxin activity
HPS44_26430	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPS44_26435	COG0584	glycerophosphoryl diester phosphodiesterase
HPS44_26445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS44_26455	COG4181	ATPase activity
HPS44_26465	COG1178	ABC-type Fe3 transport system permease component
HPS44_26470	COG3842	ATPase activity
HPS44_26475	COG0583	DNA-binding transcription factor activity
HPS44_26480	COG0560	Phosphoserine phosphatase
HPS44_26495	COG0583	DNA-binding transcription factor activity
HPS44_26510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS44_26525	COG0583	DNA-binding transcription factor activity
HPS44_26530	COG4336	lyase activity
HPS44_26560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_26580	COG2816	NAD+ diphosphatase activity
HPS44_26605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_26610	COG0765	amino acid transport
HPS44_26615	COG1126	abc transporter atp-binding protein
HPS44_26620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPS44_26625	COG1758	RNA polymerase activity
HPS44_26630	COG0194	GDP metabolic process
HPS44_26635	COG3258	Cytochrome c
HPS44_26640	COG2863	cytochrome
HPS44_26645	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_26650	COG0791	NLP P60 protein
HPS44_26665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPS44_26670	COG0833	amino acid
HPS44_26680	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPS44_26685	COG1561	YicC-like family, N-terminal region
HPS44_26690	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPS44_26700	COG1960	acyl-CoA dehydrogenase activity
HPS44_26715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPS44_26720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPS44_26725	COG0174	glutamine synthetase
HPS44_26735	COG2204	response regulator
HPS44_26740	COG0583	DNA-binding transcription factor activity
HPS44_26745	COG1741	Belongs to the pirin family
HPS44_26750	COG1741	Belongs to the pirin family
HPS44_26755	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HPS44_26760	COG1690	Belongs to the RtcB family
HPS44_26765	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_26770	COG3842	ATPase activity
HPS44_26775	COG4149	molybdate abc transporter
HPS44_26780	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS44_26790	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_26805	COG0583	DNA-binding transcription factor activity
HPS44_26815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPS44_26825	COG0783	Belongs to the Dps family
HPS44_26835	COG0457	Tetratricopeptide repeat
HPS44_26840	COG0438	transferase activity, transferring glycosyl groups
HPS44_26865	COG4783	chaperone-mediated protein folding
HPS44_26865	COG1560	Kdo2-lipid A biosynthetic process
HPS44_26870	COG3866	Pectate lyase
HPS44_26885	COG0745	RESPONSE REGULATOR receiver
HPS44_26890	COG2205	protein histidine kinase activity
HPS44_26905	COG3842	ATPase activity
HPS44_26910	COG0395	ABC-type sugar transport system, permease component
HPS44_26915	COG1175	transmembrane transport
HPS44_26920	COG1653	transport
HPS44_26930	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPS44_26945	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_26970	COG1794	racemase activity, acting on amino acids and derivatives
HPS44_26975	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS44_26985	COG0583	DNA-binding transcription factor activity
HPS44_26990	COG0625	glutathione transferase activity
HPS44_26995	COG2133	pyrroloquinoline quinone binding
HPS44_27005	COG0697	spore germination
HPS44_27010	COG2363	Small membrane protein
HPS44_27030	COG0010	Belongs to the arginase family
HPS44_27040	COG1464	Belongs to the NlpA lipoprotein family
HPS44_27050	COG2814	Major facilitator Superfamily
HPS44_27060	COG1408	metallophosphoesterase
HPS44_27070	COG0688	phosphatidylethanolamine metabolic process
HPS44_27075	COG0488	(ABC) transporter
HPS44_27100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_27105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPS44_27110	COG5001	Diguanylate cyclase
HPS44_27110	COG3300	MHYT domain
HPS44_27125	COG2814	Major facilitator Superfamily
HPS44_27150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPS44_27155	COG2204	response regulator
HPS44_27190	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_27210	COG0693	protein deglycase activity
HPS44_27230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS44_27240	COG1289	transmembrane transporter activity
HPS44_27245	COG3300	MHYT domain
HPS44_27245	COG5001	Diguanylate cyclase
HPS44_27260	COG4774	siderophore transport
HPS44_27295	COG1253	flavin adenine dinucleotide binding
HPS44_27310	COG2205	protein histidine kinase activity
HPS44_27480	COG3706	GGDEF domain
HPS44_27485	COG0789	Transcriptional regulator
HPS44_27495	COG3706	GGDEF domain
HPS44_27525	COG1116	anion transmembrane transporter activity
HPS44_27530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_27535	COG4521	taurine ABC transporter
HPS44_27560	COG0793	Belongs to the peptidase S41A family
HPS44_27580	COG0628	permease
HPS44_27590	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPS44_27605	COG0531	amino acid
HPS44_27615	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS44_27620	COG4608	Belongs to the ABC transporter superfamily
HPS44_27625	COG0444	Belongs to the ABC transporter superfamily
HPS44_27635	COG0601	transmembrane transport
HPS44_27640	COG0747	negative chemotaxis
HPS44_27650	COG0251	oxidation-reduction process
HPS44_27670	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS44_27685	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HPS44_27700	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPS44_27710	COG3971	2-oxopent-4-enoate hydratase activity
HPS44_27740	COG0625	glutathione transferase activity
HPS44_27755	COG0477	Major facilitator Superfamily
HPS44_27765	COG0579	oxidoreductase
HPS44_27780	COG0625	glutathione transferase activity
HPS44_27795	COG0431	NADPH-dependent FMN reductase
HPS44_27805	COG0798	PFAM Bile acid sodium symporter
HPS44_27815	COG0640	Transcriptional regulator
HPS44_27820	COG0071	Belongs to the small heat shock protein (HSP20) family
HPS44_27855	COG1914	H( )-stimulated, divalent metal cation uptake system
HPS44_27860	COG0589	response to stress
HPS44_27875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPS44_27880	COG2197	response regulator
HPS44_27895	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HPS44_27900	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPS44_27905	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HPS44_27915	COG0589	response to stress
HPS44_27925	COG0589	response to stress
HPS44_27935	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPS44_27955	COG1126	abc transporter atp-binding protein
HPS44_27960	COG0765	amino acid transport
HPS44_27965	COG4597	amino acid ABC transporter
HPS44_27970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_27975	COG0626	cystathionine gamma-synthase activity
HPS44_27980	COG0583	DNA-binding transcription factor activity
HPS44_28000	COG0444	Belongs to the ABC transporter superfamily
HPS44_28010	COG0601	transmembrane transport
HPS44_28015	COG0747	negative chemotaxis
HPS44_28025	COG0583	DNA-binding transcription factor activity
HPS44_28030	COG1335	isochorismatase
HPS44_28035	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS44_28045	COG2358	TRAP transporter, solute receptor (TAXI family
HPS44_28050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_28055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_28065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS44_28070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPS44_28070	COG0519	Catalyzes the synthesis of GMP from XMP
HPS44_28080	COG1276	copper resistance
HPS44_28100	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_28105	COG3386	PFAM SMP-30 Gluconolaconase
HPS44_28110	COG2721	sulfolactate sulfo-lyase activity
HPS44_28125	COG0642	Histidine kinase
HPS44_28130	COG0745	RESPONSE REGULATOR receiver
HPS44_28140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS44_28145	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HPS44_28150	COG3842	ATPase activity
HPS44_28155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPS44_28175	COG0586	Pfam SNARE associated Golgi protein
HPS44_28180	COG0390	transport system, permease component
HPS44_28190	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HPS44_28240	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS44_28245	COG1120	ATPase activity
HPS44_28250	COG1126	abc transporter atp-binding protein
HPS44_28255	COG0765	amino acid transport
HPS44_28265	COG2070	2-Nitropropane dioxygenase
HPS44_28270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_28280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS44_28305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPS44_28320	COG1846	Transcriptional regulator
HPS44_28330	COG4191	Histidine kinase
HPS44_28335	COG4566	intracellular signal transduction
HPS44_28360	COG0583	DNA-binding transcription factor activity
HPS44_28390	COG0765	amino acid transport
HPS44_28410	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HPS44_28435	COG0251	oxidation-reduction process
HPS44_28480	COG4948	Mandelate Racemase Muconate Lactonizing
HPS44_28490	COG1802	Transcriptional regulator
HPS44_28495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_28510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS44_28535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_28540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS44_28545	COG1116	anion transmembrane transporter activity
HPS44_28575	COG3154	lipid carrier protein
HPS44_28580	COG0826	peptidase U32
HPS44_28585	COG0826	peptidase U32
HPS44_28590	COG2197	response regulator
HPS44_28595	COG3850	Histidine kinase
HPS44_28600	COG1763	Mo-molybdopterin cofactor biosynthetic process
HPS44_28605	COG0288	reversible hydration of carbon dioxide
HPS44_28610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPS44_28615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS44_28620	COG2181	nitrate reductase activity
HPS44_28625	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPS44_28630	COG1140	nitrate reductase beta subunit
HPS44_28635	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPS44_28640	COG2223	nitrite transmembrane transporter activity
HPS44_28665	COG0583	DNA-binding transcription factor activity
HPS44_28685	COG0583	DNA-binding transcription factor activity
HPS44_28695	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_28725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_28745	COG2070	2-Nitropropane dioxygenase
HPS44_28760	COG5002	protein histidine kinase activity
HPS44_28765	COG0745	RESPONSE REGULATOR receiver
HPS44_28770	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HPS44_28775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPS44_28785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS44_28790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS44_28805	COG0783	Belongs to the Dps family
HPS44_28835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_28840	COG0697	spore germination
HPS44_28845	COG2879	small protein
HPS44_28850	COG1966	Carbon starvation protein
HPS44_28870	COG0697	spore germination
HPS44_28875	COG0583	DNA-binding transcription factor activity
HPS44_28880	COG4521	taurine ABC transporter
HPS44_28885	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HPS44_28890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_28915	COG0235	Class ii aldolase
HPS44_28935	COG0523	cobalamin synthesis protein
HPS44_28940	COG1228	amidohydrolase
HPS44_28945	COG4172	Belongs to the ABC transporter superfamily
HPS44_28950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_28955	COG0601	transmembrane transport
HPS44_28960	COG4166	transmembrane transport
HPS44_28975	COG1414	Transcriptional regulator
HPS44_28980	COG0513	Belongs to the DEAD box helicase family
HPS44_28985	COG0602	queuosine metabolic process
HPS44_28990	COG0720	synthase
HPS44_29000	COG1289	transmembrane transporter activity
HPS44_29010	COG1566	PFAM secretion protein HlyD family protein
HPS44_29025	COG0028	Belongs to the TPP enzyme family
HPS44_29035	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_29045	COG0400	carboxylic ester hydrolase activity
HPS44_29050	COG0833	amino acid
HPS44_29070	COG0587	DNA-directed DNA polymerase activity
HPS44_29090	COG0667	Aldo Keto reductase
HPS44_29100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPS44_29125	COG0765	amino acid transport
HPS44_29130	COG0765	amino acid transport
HPS44_29135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_29140	COG0436	Aminotransferase
HPS44_29145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS44_29190	COG1309	transcriptional regulator
HPS44_29195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPS44_29200	COG3038	cytochrome b561
HPS44_29235	COG0840	transmembrane signaling receptor activity
HPS44_29300	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HPS44_29320	COG4774	siderophore transport
HPS44_29325	COG2345	Transcriptional regulator
HPS44_29335	COG1414	Transcriptional regulator
HPS44_29345	COG0477	Major facilitator Superfamily
HPS44_29350	COG0667	Aldo Keto reductase
HPS44_29360	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_29365	COG1309	transcriptional regulator
HPS44_29385	COG1683	Conserved Protein
HPS44_29395	COG2207	Transcriptional regulator
HPS44_29415	COG2885	chlorophyll binding
HPS44_29415	COG3047	cAMP biosynthetic process
HPS44_29420	COG3795	YCII-related domain
HPS44_29425	COG3795	YCII-related domain
HPS44_29435	COG4941	Belongs to the sigma-70 factor family
HPS44_29445	COG0697	spore germination
HPS44_29455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPS44_29465	COG0583	DNA-binding transcription factor activity