locus-tag	class	description
Acfer_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Acfer_0003	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Acfer_0004	COG0592	DNA-directed DNA polymerase activity
Acfer_0005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Acfer_0008	COG0187	DNA topoisomerase II activity
Acfer_0010	COG0730	response to heat
Acfer_0011	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Acfer_0013	COG0583	DNA-binding transcription factor activity
Acfer_0014	COG0281	malic enzyme
Acfer_0018	COG0411	ABC transporter
Acfer_0020	COG0517	IMP dehydrogenase activity
Acfer_0028	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Acfer_0030	COG1473	amidohydrolase
Acfer_0034	COG3279	Response regulator of the LytR AlgR family
Acfer_0038	COG0360	Binds together with S18 to 16S ribosomal RNA
Acfer_0039	COG0629	single-stranded DNA binding
Acfer_0040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Acfer_0042	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Acfer_0044	COG0305	Participates in initiation and elongation during chromosome replication
Acfer_0045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Acfer_0046	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Acfer_0047	COG0786	glutamate:sodium symporter activity
Acfer_0050	COG1115	amino acid carrier protein
Acfer_0052	COG2116	formate transmembrane transporter activity
Acfer_0057	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Acfer_0061	COG1971	Probably functions as a manganese efflux pump
Acfer_0062	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Acfer_0063	COG0697	spore germination
Acfer_0066	COG2195	Cleaves the N-terminal amino acid of tripeptides
Acfer_0068	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Acfer_0071	COG4948	Mandelate Racemase Muconate Lactonizing
Acfer_0072	COG2610	gluconate transmembrane transporter activity
Acfer_0073	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Acfer_0075	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Acfer_0075	COG0674	pyruvate-flavodoxin oxidoreductase activity
Acfer_0076	COG1013	pyruvate-flavodoxin oxidoreductase activity
Acfer_0078	COG0129	dihydroxy-acid dehydratase activity
Acfer_0080	COG0427	acetyl-CoA hydrolase
Acfer_0082	COG2721	sulfolactate sulfo-lyase activity
Acfer_0083	COG1757	Na H antiporter
Acfer_0084	COG0735	belongs to the Fur family
Acfer_0085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Acfer_0086	COG1121	(ABC) transporter
Acfer_0087	COG0803	Belongs to the bacterial solute-binding protein 9 family
Acfer_0089	COG0745	RESPONSE REGULATOR receiver
Acfer_0090	COG2205	protein histidine kinase activity
Acfer_0093	COG1733	regulation of RNA biosynthetic process
Acfer_0095	COG0583	DNA-binding transcription factor activity
Acfer_0096	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Acfer_0097	COG2851	Citrate transporter
Acfer_0098	COG0745	RESPONSE REGULATOR receiver
Acfer_0099	COG0642	Histidine kinase
Acfer_0103	COG2078	PFAM AMMECR1 domain protein
Acfer_0103	COG3885	ferrous iron binding
Acfer_0108	COG2878	Part of a membrane complex involved in electron transport
Acfer_0108	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
Acfer_0109	COG4657	Part of a membrane complex involved in electron transport
Acfer_0110	COG4660	Part of a membrane complex involved in electron transport
Acfer_0111	COG4659	FMN binding
Acfer_0112	COG4658	electron transport chain
Acfer_0113	COG4656	Part of a membrane complex involved in electron transport
Acfer_0116	COG2204	response regulator
Acfer_0117	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Acfer_0118	COG0772	Belongs to the SEDS family
Acfer_0119	COG0768	penicillin binding
Acfer_0125	COG5002	protein histidine kinase activity
Acfer_0130	COG1966	Carbon starvation protein
Acfer_0131	COG0277	FAD linked oxidase domain protein
Acfer_0133	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Acfer_0134	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Acfer_0137	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Acfer_0138	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Acfer_0138	COG1263	PTS System
Acfer_0140	COG0012	GTP binding
Acfer_0141	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Acfer_0142	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Acfer_0143	COG1713	HD superfamily hydrolase involved in NAD metabolism
Acfer_0144	COG1316	TRANSCRIPTIONal
Acfer_0145	COG0799	negative regulation of ribosome biogenesis
Acfer_0146	COG2996	Protein conserved in bacteria
Acfer_0150	COG0583	DNA-binding transcription factor activity
Acfer_0152	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Acfer_0153	COG0066	3-isopropylmalate dehydratase activity
Acfer_0154	COG0473	3-isopropylmalate dehydrogenase activity
Acfer_0155	COG0519	Catalyzes the synthesis of GMP from XMP
Acfer_0156	COG0440	acetolactate synthase activity
Acfer_0157	COG0028	Belongs to the TPP enzyme family
Acfer_0158	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Acfer_0159	COG0745	RESPONSE REGULATOR receiver
Acfer_0160	COG2205	protein histidine kinase activity
Acfer_0161	COG0028	Belongs to the TPP enzyme family
Acfer_0162	COG0440	acetolactate synthase activity
Acfer_0166	COG5295	Hep Hag repeat protein
Acfer_0167	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Acfer_0168	COG1924	4 iron, 4 sulfur cluster binding
Acfer_0169	COG2244	polysaccharide biosynthetic process
Acfer_0172	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Acfer_0173	COG0583	DNA-binding transcription factor activity
Acfer_0174	COG0739	heme binding
Acfer_0175	COG1695	Transcriptional regulator
Acfer_0176	COG4946	Tricorn protease homolog
Acfer_0176	COG0823	Involved in the tonB-independent uptake of proteins
Acfer_0176	COG1506	peptidase
Acfer_0177	COG3384	dioxygenase
Acfer_0178	COG1012	belongs to the aldehyde dehydrogenase family
Acfer_0179	COG2309	aminopeptidase activity
Acfer_0181	COG1269	ATP hydrolysis coupled proton transport
Acfer_0182	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Acfer_0185	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
Acfer_0186	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Acfer_0189	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acfer_0192	COG0492	ferredoxin-NADP+ reductase activity
Acfer_0194	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Acfer_0196	COG1278	Cold shock
Acfer_0197	COG1028	Short-chain dehydrogenase reductase Sdr
Acfer_0198	COG1114	Component of the transport system for branched-chain amino acids
Acfer_0203	COG1027	Aspartate ammonia-lyase
Acfer_0204	COG1380	Effector of murein hydrolase LrgA
Acfer_0205	COG1346	cytolysis
Acfer_0206	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acfer_0207	COG1288	antiporter activity
Acfer_0208	COG0385	Bile acid
Acfer_0210	COG2084	Dehydrogenase
Acfer_0212	COG1176	ABC-type spermidine putrescine transport system, permease component I
Acfer_0213	COG3842	ATPase activity
Acfer_0214	COG0251	oxidation-reduction process
Acfer_0215	COG1414	Transcriptional regulator
Acfer_0216	COG0010	Belongs to the arginase family
Acfer_0217	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Acfer_0222	COG0786	glutamate:sodium symporter activity
Acfer_0223	COG1704	LemA family
Acfer_0227	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Acfer_0228	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Acfer_0229	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Acfer_0230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Acfer_0231	COG1136	(ABC) transporter
Acfer_0232	COG0577	efflux transmembrane transporter activity
Acfer_0232	COG1136	(ABC) transporter
Acfer_0237	COG3404	Formiminotransferase-cyclodeaminase
Acfer_0241	COG2986	histidine ammonia-lyase
Acfer_0242	COG2056	Na+-H+ antiporter family
Acfer_0244	COG0277	FAD linked oxidase domain protein
Acfer_0246	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Acfer_0248	COG4178	(ABC) transporter
Acfer_0249	COG1115	amino acid carrier protein
Acfer_0251	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Acfer_0258	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Acfer_0259	COG0250	Participates in transcription elongation, termination and antitermination
Acfer_0260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Acfer_0261	COG0081	regulation of translation
Acfer_0262	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Acfer_0263	COG0222	ribosome binding
Acfer_0264	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Acfer_0265	COG2011	ABC-type metal ion transport system permease component
Acfer_0267	COG1473	amidohydrolase
Acfer_0268	COG2707	UPF0756 membrane protein
Acfer_0271	COG1538	Outer membrane efflux protein
Acfer_0272	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Acfer_0273	COG1131	(ABC) transporter
Acfer_0274	COG0842	Transport permease protein
Acfer_0275	COG0842	Transport permease protein
Acfer_0282	COG0512	Glutamine amidotransferase of anthranilate synthase
Acfer_0282	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Acfer_0285	COG0135	phosphoribosylanthranilate isomerase activity
Acfer_0286	COG0133	tryptophan synthase activity
Acfer_0287	COG0159	tryptophan synthase activity
Acfer_0288	COG1316	TRANSCRIPTIONal
Acfer_0293	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Acfer_0296	COG2195	Cleaves the N-terminal amino acid of tripeptides
Acfer_0298	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Acfer_0302	COG0181	hydroxymethylbilane synthase activity
Acfer_0304	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Acfer_0304	COG1648	precorrin-2 dehydrogenase activity
Acfer_0305	COG1773	rubredoxin
Acfer_0305	COG1592	Rubrerythrin
Acfer_0307	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
Acfer_0308	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Acfer_0309	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Acfer_0311	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Acfer_0313	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Acfer_0313	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Acfer_0314	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Acfer_0316	COG0515	serine threonine protein kinase
Acfer_0316	COG2815	serine threonine protein kinase
Acfer_0317	COG1162	GTPase activity
Acfer_0318	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Acfer_0321	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Acfer_0322	COG0811	peptide transport
Acfer_0323	COG0848	biopolymer transport protein
Acfer_0327	COG0798	PFAM Bile acid sodium symporter
Acfer_0330	COG1733	regulation of RNA biosynthetic process
Acfer_0333	COG0436	Aminotransferase
Acfer_0335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Acfer_0336	COG1177	transmembrane transport
Acfer_0337	COG1176	ABC-type spermidine putrescine transport system, permease component I
Acfer_0339	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Acfer_0341	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Acfer_0343	COG0085	RNA polymerase activity
Acfer_0344	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Acfer_0346	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Acfer_0347	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Acfer_0348	COG1122	ATPase activity
Acfer_0349	COG1122	ATPase activity
Acfer_0350	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Acfer_0352	COG4206	TonB-dependent receptor
Acfer_0355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Acfer_0355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Acfer_0357	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Acfer_0358	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Acfer_0360	COG1418	mRNA catabolic process
Acfer_0363	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Acfer_0364	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Acfer_0367	COG1151	hydroxylamine reductase activity
Acfer_0369	COG3189	MarR family transcriptional regulator
Acfer_0371	COG1301	dicarboxylic acid transport
Acfer_0372	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Acfer_0373	COG0583	DNA-binding transcription factor activity
Acfer_0374	COG1268	BioY protein
Acfer_0376	COG1021	2,3-dihydroxybenzoate-AMP ligase
Acfer_0379	COG1720	tRNA m6t6A37 methyltransferase activity
Acfer_0384	COG2731	YhcH YjgK YiaL family protein
Acfer_0385	COG4771	TonB-dependent receptor
Acfer_0393	COG1827	regulation of RNA biosynthetic process
Acfer_0397	COG0525	valine-tRNA ligase activity
Acfer_0398	COG0285	dihydrofolate synthase activity
Acfer_0401	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Acfer_0402	COG0058	SHG alpha-glucan phosphorylase activity
Acfer_0403	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Acfer_0404	COG0297	glycogen (starch) synthase activity
Acfer_0405	COG0366	Alpha amylase catalytic
Acfer_0405	COG3103	Sh3 type 3 domain protein
Acfer_0406	COG2851	Citrate transporter
Acfer_0407	COG2851	Citrate transporter
Acfer_0410	COG3052	prosthetic group binding
Acfer_0411	COG0583	DNA-binding transcription factor activity
Acfer_0412	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
Acfer_0413	COG2855	membrane
Acfer_0415	COG1760	l-serine dehydratase
Acfer_0416	COG1760	l-serine dehydratase
Acfer_0417	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Acfer_0419	COG0254	rRNA binding
Acfer_0420	COG3872	metal-dependent enzyme
Acfer_0421	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Acfer_0422	COG2890	protein-(glutamine-N5) methyltransferase activity
Acfer_0423	COG0009	L-threonylcarbamoyladenylate synthase
Acfer_0424	COG0698	ribose 5-phosphate isomerase
Acfer_0425	COG4475	Protein of unknown function (DUF436)
Acfer_0426	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Acfer_0427	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Acfer_0428	COG2131	deaminase
Acfer_0435	COG0589	response to stress
Acfer_0436	COG0589	response to stress
Acfer_0437	COG0589	response to stress
Acfer_0438	COG0589	response to stress
Acfer_0439	COG0589	response to stress
Acfer_0440	COG1757	Na H antiporter
Acfer_0441	COG1115	amino acid carrier protein
Acfer_0442	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acfer_0444	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Acfer_0445	COG0237	dephospho-CoA kinase activity
Acfer_0448	COG2610	gluconate transmembrane transporter activity
Acfer_0449	COG0396	ATPase activity
Acfer_0450	COG0719	Fe-S assembly protein
Acfer_0452	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Acfer_0453	COG0822	iron-sulfur transferase activity
Acfer_0454	COG1185	polyribonucleotide nucleotidyltransferase activity
Acfer_0455	COG2190	(PTS) system
Acfer_0457	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Acfer_0458	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Acfer_0459	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Acfer_0462	COG0351	phosphomethylpyrimidine kinase
Acfer_0463	COG0352	thiamine-phosphate diphosphorylase activity
Acfer_0466	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Acfer_0467	COG0228	four-way junction DNA binding
Acfer_0471	COG0336	Belongs to the RNA methyltransferase TrmD family
Acfer_0472	COG0335	large ribosomal subunit rRNA binding
Acfer_0473	COG0681	Belongs to the peptidase S26 family
Acfer_0475	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Acfer_0476	COG0792	nuclease activity
Acfer_0477	COG0606	chelatase, subunit chli
Acfer_0478	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Acfer_0481	COG0572	uridine kinase
Acfer_0482	COG0436	Aminotransferase
Acfer_0484	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Acfer_0486	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Acfer_0488	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Acfer_0491	COG1611	Belongs to the LOG family
Acfer_0492	COG0463	Glycosyl transferase, family 2
Acfer_0493	COG1442	glycosyl transferase family 8
Acfer_0495	COG1216	Glycosyl transferase, family 2
Acfer_0501	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acfer_0502	COG1115	amino acid carrier protein
Acfer_0503	COG0544	peptidyl-prolyl cis-trans isomerase activity
Acfer_0504	COG0740	serine-type endopeptidase activity
Acfer_0505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Acfer_0506	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Acfer_0507	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Acfer_0509	COG4796	Type ii and iii secretion system protein
Acfer_0511	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Acfer_0512	COG2860	membrane
Acfer_0513	COG1666	GTP binding
Acfer_0515	COG0556	nucleotide-excision repair
Acfer_0517	COG0322	excinuclease ABC activity
Acfer_0518	COG1773	rubredoxin
Acfer_0519	COG0583	DNA-binding transcription factor activity
Acfer_0521	COG1979	alcohol dehydrogenase
Acfer_0524	COG0656	L-ascorbic acid biosynthetic process
Acfer_0525	COG0656	L-ascorbic acid biosynthetic process
Acfer_0532	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Acfer_0533	COG0805	protein transport
Acfer_0537	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Acfer_0539	COG0583	DNA-binding transcription factor activity
Acfer_0542	COG0561	phosphatase activity
Acfer_0544	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Acfer_0549	COG1024	Enoyl-CoA hydratase
Acfer_0551	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Acfer_0556	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Acfer_0560	COG0569	domain protein
Acfer_0562	COG4464	protein tyrosine phosphatase activity
Acfer_0565	COG0489	protein tyrosine kinase activity
Acfer_0566	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Acfer_0567	COG1215	transferase activity, transferring glycosyl groups
Acfer_0570	COG0438	transferase activity, transferring glycosyl groups
Acfer_0573	COG1215	transferase activity, transferring glycosyl groups
Acfer_0579	COG1091	dTDP-4-dehydrorhamnose reductase activity
Acfer_0593	COG0166	Belongs to the GPI family
Acfer_0594	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Acfer_0595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Acfer_0596	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Acfer_0597	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Acfer_0599	COG0165	Argininosuccinate lyase
Acfer_0600	COG1473	amidohydrolase
Acfer_0601	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Acfer_0603	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Acfer_0604	COG1227	inorganic diphosphatase activity
Acfer_0612	COG3681	Belongs to the UPF0597 family
Acfer_0613	COG2252	PERMEase
Acfer_0615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Acfer_0616	COG1966	Carbon starvation protein
Acfer_0618	COG0179	Fumarylacetoacetate (FAA) hydrolase
Acfer_0619	COG1702	phosphate starvation-inducible protein PhoH
Acfer_0620	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Acfer_0622	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Acfer_0623	COG1253	flavin adenine dinucleotide binding
Acfer_0624	COG1381	Involved in DNA repair and RecF pathway recombination
Acfer_0626	COG0708	Exodeoxyribonuclease III
Acfer_0628	COG0583	DNA-binding transcription factor activity
Acfer_0631	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Acfer_0632	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Acfer_0635	COG1982	Orn Lys Arg decarboxylase major
Acfer_0636	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Acfer_0637	COG0470	DNA polymerase III
Acfer_0638	COG1774	PSP1 C-terminal conserved region
Acfer_0639	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Acfer_0640	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Acfer_0643	COG0534	Mate efflux family protein
Acfer_0645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Acfer_0647	COG3858	chitin binding
Acfer_0648	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acfer_0649	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acfer_0650	COG0765	amino acid transport
Acfer_0651	COG1126	abc transporter atp-binding protein
Acfer_0652	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Acfer_0653	COG0653	protein targeting
Acfer_0654	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Acfer_0657	COG2884	Cell division ATP-binding protein ftsE
Acfer_0658	COG2177	Part of the ABC transporter FtsEX involved in
Acfer_0660	COG0793	Belongs to the peptidase S41A family
Acfer_0662	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Acfer_0664	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Acfer_0665	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Acfer_0670	COG0519	Catalyzes the synthesis of GMP from XMP
Acfer_0677	COG0534	Mate efflux family protein
Acfer_0678	COG1473	amidohydrolase
Acfer_0681	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Acfer_0683	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Acfer_0687	COG1959	2 iron, 2 sulfur cluster binding
Acfer_0691	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Acfer_0693	COG0281	malic enzyme
Acfer_0699	COG0471	metal ion transport
Acfer_0700	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Acfer_0701	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Acfer_0702	COG1420	regulation of RNA biosynthetic process
Acfer_0703	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Acfer_0705	COG0484	heat shock protein binding
Acfer_0709	COG2264	protein methyltransferase activity
Acfer_0710	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Acfer_0711	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Acfer_0712	COG0537	adenosine 5'-monophosphoramidase activity
Acfer_0714	COG1610	YqeY-like protein
Acfer_0715	COG0436	Aminotransferase
Acfer_0718	COG4956	integral membrane protein (PIN domain superfamily)
Acfer_0719	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Acfer_0719	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Acfer_0720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Acfer_0721	COG0215	cysteine-tRNA ligase activity
Acfer_0722	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Acfer_0731	COG0562	UDP-galactopyranose mutase
Acfer_0743	COG3475	LICD family
Acfer_0745	COG1088	dTDP-glucose 4,6-dehydratase activity
Acfer_0746	COG1216	Glycosyl transferase, family 2
Acfer_0746	COG1442	glycosyl transferase family 8
Acfer_0747	COG1216	Glycosyl transferase, family 2
Acfer_0748	COG1442	glycosyl transferase family 8
Acfer_0748	COG1216	Glycosyl transferase, family 2
Acfer_0761	COG1518	maintenance of DNA repeat elements
Acfer_0762	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Acfer_0767	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Acfer_0768	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Acfer_0769	COG0688	phosphatidylethanolamine metabolic process
Acfer_0771	COG1215	transferase activity, transferring glycosyl groups
Acfer_0775	COG0385	Bile acid
Acfer_0777	COG1126	abc transporter atp-binding protein
Acfer_0778	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acfer_0779	COG0765	amino acid transport
Acfer_0780	COG0765	amino acid transport
Acfer_0783	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Acfer_0785	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Acfer_0786	COG1250	3-hydroxyacyl-CoA dehydrogenase
Acfer_0788	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Acfer_0790	COG1464	Belongs to the NlpA lipoprotein family
Acfer_0791	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acfer_0792	COG0564	pseudouridine synthase activity
Acfer_0799	COG3706	GGDEF domain
Acfer_0802	COG4251	negative regulation of phosphorylation
Acfer_0802	COG2203	Gaf domain
Acfer_0802	COG3706	GGDEF domain
Acfer_0802	COG5001	Diguanylate cyclase
Acfer_0805	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Acfer_0806	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Acfer_0809	COG0640	Transcriptional regulator
Acfer_0810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Acfer_0812	COG0515	serine threonine protein kinase
Acfer_0813	COG2384	SAM-dependent methyltransferase
Acfer_0814	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Acfer_0817	COG0463	Glycosyl transferase, family 2
Acfer_0818	COG0791	NLP P60 protein
Acfer_0818	COG1388	LysM domain
Acfer_0818	COG3103	Sh3 type 3 domain protein
Acfer_0820	COG0745	RESPONSE REGULATOR receiver
Acfer_0821	COG5002	protein histidine kinase activity
Acfer_0823	COG3679	Belongs to the UPF0342 family
Acfer_0825	COG0697	spore germination
Acfer_0827	COG1970	mechanosensitive ion channel activity
Acfer_0828	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Acfer_0829	COG0318	PFAM AMP-dependent synthetase and ligase
Acfer_0831	COG3850	Histidine kinase
Acfer_0832	COG2197	response regulator
Acfer_0834	COG0737	Belongs to the 5'-nucleotidase family
Acfer_0843	COG1302	Protein conserved in bacteria
Acfer_0846	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Acfer_0848	COG1570	exodeoxyribonuclease VII activity
Acfer_0849	COG1722	exodeoxyribonuclease VII activity
Acfer_0851	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Acfer_0852	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Acfer_0853	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Acfer_0855	COG0497	DNA recombination
Acfer_0856	COG0494	nUDIX hydrolase
Acfer_0857	COG2359	stage V sporulation protein S
Acfer_0859	COG1116	anion transmembrane transporter activity
Acfer_0860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Acfer_0865	COG0371	Dehydrogenase
Acfer_0866	COG0534	Mate efflux family protein
Acfer_0868	COG2200	EAL domain
Acfer_0868	COG2202	Pas domain
Acfer_0868	COG2199	diguanylate cyclase activity
Acfer_0876	COG2217	Heavy metal translocating P-type atpase
Acfer_0882	COG1132	(ABC) transporter
Acfer_0883	COG1132	(ABC) transporter
Acfer_0885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Acfer_0886	COG0072	phenylalanine-tRNA ligase activity
Acfer_0886	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acfer_0893	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Acfer_0894	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Acfer_0896	COG4472	Bacterial protein of unknown function (DUF965)
Acfer_0897	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Acfer_0898	COG3906	Belongs to the UPF0473 family
Acfer_0899	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Acfer_0901	COG0006	proline dipeptidase activity
Acfer_0902	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Acfer_0903	COG0406	alpha-ribazole phosphatase activity
Acfer_0906	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Acfer_0908	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Acfer_0911	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Acfer_0912	COG0583	DNA-binding transcription factor activity
Acfer_0914	COG4496	protein, YerC YecD
Acfer_0915	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Acfer_0918	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Acfer_0919	COG0131	Imidazoleglycerol-phosphate dehydratase
Acfer_0920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Acfer_0921	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Acfer_0922	COG0107	imidazoleglycerol-phosphate synthase activity
Acfer_0923	COG0140	phosphoribosyl-ATP diphosphatase activity
Acfer_0923	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Acfer_0924	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Acfer_0925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Acfer_0926	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Acfer_0927	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Acfer_0931	COG0126	phosphoglycerate kinase activity
Acfer_0931	COG0149	triose-phosphate isomerase activity
Acfer_0933	COG0148	phosphopyruvate hydratase activity
Acfer_0934	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Acfer_0935	COG2357	RelA SpoT domain protein
Acfer_0936	COG0745	RESPONSE REGULATOR receiver
Acfer_0937	COG5002	protein histidine kinase activity
Acfer_0938	COG0673	inositol 2-dehydrogenase activity
Acfer_0944	COG2814	Major facilitator Superfamily
Acfer_0950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acfer_0952	COG0583	DNA-binding transcription factor activity
Acfer_0959	COG0242	peptide deformylase activity
Acfer_0960	COG1309	transcriptional regulator
Acfer_0961	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Acfer_0962	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Acfer_0966	COG0583	DNA-binding transcription factor activity
Acfer_0974	COG0557	exoribonuclease II activity
Acfer_0976	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Acfer_0981	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Acfer_0985	COG2086	electron transfer activity
Acfer_0986	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Acfer_0987	COG2176	DNA-directed DNA polymerase activity
Acfer_0994	COG1773	rubredoxin
Acfer_0994	COG1592	Rubrerythrin
Acfer_0997	COG1309	transcriptional regulator
Acfer_0998	COG0191	fructose-bisphosphate aldolase activity
Acfer_0999	COG0564	pseudouridine synthase activity
Acfer_1000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Acfer_1002	COG1606	tRNA processing
Acfer_1003	COG1691	(AIR) carboxylase
Acfer_1004	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Acfer_1005	COG0310	cobalt ion transport
Acfer_1007	COG1122	ATPase activity
Acfer_1009	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Acfer_1010	COG0785	Cytochrome C biogenesis protein
Acfer_1011	COG1301	dicarboxylic acid transport
Acfer_1012	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Acfer_1013	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Acfer_1014	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Acfer_1015	COG0513	Belongs to the DEAD box helicase family
Acfer_1016	COG1058	Belongs to the CinA family
Acfer_1016	COG1546	Belongs to the CinA family
Acfer_1017	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Acfer_1018	COG1426	Protein conserved in bacteria
Acfer_1019	COG1674	ftsk spoiiie
Acfer_1020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Acfer_1024	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Acfer_1026	COG0613	PHP domain protein
Acfer_1029	COG2814	Major facilitator Superfamily
Acfer_1033	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Acfer_1033	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Acfer_1033	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Acfer_1034	COG1105	Belongs to the carbohydrate kinase PfkB family
Acfer_1035	COG3394	polysaccharide catabolic process
Acfer_1036	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Acfer_1037	COG0039	L-malate dehydrogenase activity
Acfer_1038	COG1362	aminopeptidase activity
Acfer_1039	COG0531	amino acid
Acfer_1040	COG3579	cysteine-type endopeptidase activity
Acfer_1044	COG1132	(ABC) transporter
Acfer_1045	COG1132	(ABC) transporter
Acfer_1046	COG0583	DNA-binding transcription factor activity
Acfer_1047	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Acfer_1053	COG2020	methyltransferase activity
Acfer_1060	COG0484	heat shock protein binding
Acfer_1067	COG2081	HI0933 family
Acfer_1070	COG2851	Citrate transporter
Acfer_1073	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
Acfer_1080	COG1475	DNA binding
Acfer_1100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acfer_1104	COG2186	Transcriptional regulator
Acfer_1109	COG0494	nUDIX hydrolase
Acfer_1125	COG0860	N-Acetylmuramoyl-L-alanine amidase
Acfer_1150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Acfer_1161	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
Acfer_1168	COG0640	Transcriptional regulator
Acfer_1173	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Acfer_1175	COG0732	type I restriction modification DNA specificity domain
Acfer_1177	COG1522	sequence-specific DNA binding
Acfer_1178	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Acfer_1179	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Acfer_1180	COG2011	ABC-type metal ion transport system permease component
Acfer_1188	COG0489	protein tyrosine kinase activity
Acfer_1189	COG4964	Belongs to the GSP D family
Acfer_1193	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Acfer_1194	COG0527	aspartate kinase activity
Acfer_1195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Acfer_1196	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Acfer_1198	COG0756	dUTP diphosphatase activity
Acfer_1200	COG0352	thiamine-phosphate diphosphorylase activity
Acfer_1201	COG2033	superoxide reductase activity
Acfer_1203	COG1328	CTP reductase activity
Acfer_1203	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Acfer_1205	COG0786	glutamate:sodium symporter activity
Acfer_1207	COG4974	Belongs to the 'phage' integrase family
Acfer_1208	COG1923	regulation of RNA biosynthetic process
Acfer_1209	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Acfer_1211	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Acfer_1217	COG1484	DNA-dependent DNA replication
Acfer_1224	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Acfer_1224	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Acfer_1225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Acfer_1226	COG1469	GTP cyclohydrolase I activity
Acfer_1227	COG0720	synthase
Acfer_1228	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Acfer_1230	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Acfer_1231	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Acfer_1232	COG0083	homoserine kinase activity
Acfer_1233	COG0460	homoserine dehydrogenase
Acfer_1234	COG4492	Belongs to the UPF0735 family
Acfer_1235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Acfer_1236	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Acfer_1238	COG1304	FMN binding
Acfer_1239	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Acfer_1239	COG0539	negative regulation of cytoplasmic translation
Acfer_1241	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Acfer_1242	COG2081	HI0933 family
Acfer_1243	COG1187	pseudouridine synthase activity
Acfer_1244	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Acfer_1246	COG1994	Peptidase M50
Acfer_1247	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Acfer_1248	COG4974	Belongs to the 'phage' integrase family
Acfer_1250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Acfer_1251	COG0758	DNA mediated transformation
Acfer_1252	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Acfer_1255	COG1047	Peptidyl-prolyl cis-trans
Acfer_1260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Acfer_1262	COG1360	Flagellar Motor Protein
Acfer_1267	COG0534	Mate efflux family protein
Acfer_1269	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Acfer_1270	COG0385	Bile acid
Acfer_1271	COG2239	Acts as a magnesium transporter
Acfer_1273	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Acfer_1275	COG0517	IMP dehydrogenase activity
Acfer_1275	COG0516	GMP reductase activity
Acfer_1276	COG0151	Belongs to the GarS family
Acfer_1277	COG0138	bifunctional purine biosynthesis protein purh
Acfer_1278	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Acfer_1279	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Acfer_1280	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Acfer_1281	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Acfer_1283	COG1193	negative regulation of DNA recombination
Acfer_1285	COG3706	GGDEF domain
Acfer_1285	COG2203	Gaf domain
Acfer_1285	COG5001	Diguanylate cyclase
Acfer_1285	COG4251	negative regulation of phosphorylation
Acfer_1293	COG2165	general secretion pathway protein
Acfer_1296	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Acfer_1297	COG3856	small basic protein
Acfer_1300	COG1181	Belongs to the D-alanine--D-alanine ligase family
Acfer_1301	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Acfer_1302	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Acfer_1304	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Acfer_1305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Acfer_1308	COG0275	rRNA processing
Acfer_1309	COG2001	Belongs to the MraZ family
Acfer_1311	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Acfer_1312	COG0284	orotidine-5'-phosphate decarboxylase activity
Acfer_1313	COG0167	dihydroorotate dehydrogenase activity
Acfer_1314	COG0543	2 iron, 2 sulfur cluster binding
Acfer_1315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Acfer_1316	COG0505	Belongs to the CarA family
Acfer_1317	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Acfer_1318	COG0540	Belongs to the ATCase OTCase family
Acfer_1320	COG1061	Type III restriction enzyme res subunit
Acfer_1325	COG2885	chlorophyll binding
Acfer_1325	COG3047	cAMP biosynthetic process
Acfer_1327	COG0493	'glutamate synthase
Acfer_1329	COG0402	S-adenosylhomocysteine deaminase activity
Acfer_1330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Acfer_1332	COG1074	ATP-dependent DNA helicase activity
Acfer_1333	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Acfer_1336	COG0037	tRNA processing
Acfer_1338	COG1234	tRNA 3'-trailer cleavage
Acfer_1341	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Acfer_1347	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Acfer_1348	COG0471	metal ion transport
Acfer_1349	COG1802	Transcriptional regulator
Acfer_1350	COG0481	GTPase activity
Acfer_1351	COG0268	Binds directly to 16S ribosomal RNA
Acfer_1352	COG0196	riboflavin kinase activity
Acfer_1353	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Acfer_1354	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Acfer_1355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Acfer_1356	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Acfer_1356	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Acfer_1358	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Acfer_1359	COG0195	Participates in both transcription termination and antitermination
Acfer_1360	COG0779	Required for maturation of 30S ribosomal subunits
Acfer_1361	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Acfer_1363	COG1473	amidohydrolase
Acfer_1365	COG2040	homocysteine
Acfer_1368	COG1115	amino acid carrier protein
Acfer_1369	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acfer_1371	COG1285	pathogenesis
Acfer_1372	COG0442	prolyl-tRNA aminoacylation
Acfer_1373	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Acfer_1374	COG0750	zinc metalloprotease
Acfer_1375	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Acfer_1376	COG0575	Belongs to the CDS family
Acfer_1377	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Acfer_1379	COG0233	cytoplasmic translational termination
Acfer_1380	COG0528	UMP kinase activity
Acfer_1381	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Acfer_1382	COG0052	Belongs to the universal ribosomal protein uS2 family
Acfer_1383	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Acfer_1385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Acfer_1387	COG2199	diguanylate cyclase activity
Acfer_1387	COG2203	Gaf domain
Acfer_1388	COG0571	ribonuclease III activity
Acfer_1389	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Acfer_1391	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Acfer_1392	COG1028	Short-chain dehydrogenase reductase Sdr
Acfer_1393	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Acfer_1394	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Acfer_1395	COG0416	fatty acid biosynthetic process
Acfer_1396	COG2030	dehydratase
Acfer_1397	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Acfer_1398	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Acfer_1403	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Acfer_1404	COG0742	ribosomal rna small subunit methyltransferase
Acfer_1411	COG1473	amidohydrolase
Acfer_1415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Acfer_1418	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Acfer_1420	COG0194	GDP metabolic process
Acfer_1421	COG2052	Domain of unknown function (DUF370)
Acfer_1422	COG1561	YicC-like family, N-terminal region
Acfer_1425	COG0129	dihydroxy-acid dehydratase activity
Acfer_1427	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Acfer_1429	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Acfer_1430	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Acfer_1431	COG0459	protein refolding
Acfer_1432	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Acfer_1434	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Acfer_1436	COG1388	LysM domain
Acfer_1436	COG3584	3D domain protein
Acfer_1437	COG0084	hydrolase, TatD family'
Acfer_1438	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acfer_1438	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acfer_1441	COG3706	GGDEF domain
Acfer_1443	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Acfer_1445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Acfer_1446	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Acfer_1447	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Acfer_1448	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Acfer_1449	COG1802	Transcriptional regulator
Acfer_1450	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Acfer_1451	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Acfer_1452	COG0786	glutamate:sodium symporter activity
Acfer_1455	COG1555	photosystem II stabilization
Acfer_1455	COG1596	polysaccharide export
Acfer_1457	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acfer_1458	COG0784	Response regulator, receiver
Acfer_1458	COG3437	response regulator, receiver
Acfer_1460	COG1811	Na channel or pump
Acfer_1461	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Acfer_1464	COG1132	(ABC) transporter
Acfer_1465	COG1132	(ABC) transporter
Acfer_1467	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Acfer_1471	COG0280	phosphate acetyltransferase
Acfer_1473	COG1362	aminopeptidase activity
Acfer_1475	COG1024	Enoyl-CoA hydratase
Acfer_1476	COG1250	3-hydroxyacyl-CoA dehydrogenase
Acfer_1478	COG0183	Belongs to the thiolase family
Acfer_1481	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Acfer_1482	COG2848	UPF0210 protein
Acfer_1485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Acfer_1486	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Acfer_1489	COG0492	ferredoxin-NADP+ reductase activity
Acfer_1494	COG1937	Protein conserved in bacteria
Acfer_1495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Acfer_1496	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Acfer_1497	COG0569	domain protein
Acfer_1498	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Acfer_1505	COG0552	protein localization to endoplasmic reticulum
Acfer_1506	COG1196	nuclear chromosome segregation
Acfer_1508	COG0564	pseudouridine synthase activity
Acfer_1509	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Acfer_1512	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Acfer_1513	COG0124	histidyl-tRNA synthetase
Acfer_1514	COG0628	permease
Acfer_1515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Acfer_1516	COG1490	D-aminoacyl-tRNA deacylase activity
Acfer_1517	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Acfer_1518	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Acfer_1518	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Acfer_1521	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Acfer_1522	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Acfer_1526	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Acfer_1527	COG2385	sporulation resulting in formation of a cellular spore
Acfer_1527	COG2247	cell wall binding repeat
Acfer_1528	COG2255	four-way junction helicase activity
Acfer_1530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Acfer_1531	COG0217	transcriptional regulatory protein
Acfer_1534	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acfer_1534	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Acfer_1537	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Acfer_1538	COG1592	Rubrerythrin
Acfer_1541	COG1464	Belongs to the NlpA lipoprotein family
Acfer_1542	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Acfer_1550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Acfer_1551	COG0798	PFAM Bile acid sodium symporter
Acfer_1554	COG3279	Response regulator of the LytR AlgR family
Acfer_1557	COG1451	nucleotide metabolic process
Acfer_1558	COG4536	flavin adenine dinucleotide binding
Acfer_1561	COG0024	Methionine aminopeptidase
Acfer_1570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Acfer_1574	COG0583	DNA-binding transcription factor activity
Acfer_1575	COG1960	acyl-CoA dehydrogenase activity
Acfer_1576	COG0426	domain, Protein
Acfer_1580	COG1214	PFAM Peptidase M22, glycoprotease
Acfer_1581	COG0802	atpase or kinase
Acfer_1582	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Acfer_1583	COG1960	acyl-CoA dehydrogenase activity
Acfer_1585	COG1388	LysM domain
Acfer_1585	COG3584	3D domain protein
Acfer_1586	COG0174	glutamine synthetase
Acfer_1589	COG4948	Mandelate Racemase Muconate Lactonizing
Acfer_1590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acfer_1592	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Acfer_1593	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Acfer_1594	COG1268	BioY protein
Acfer_1596	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Acfer_1598	COG0037	tRNA processing
Acfer_1599	COG1098	S1 RNA binding domain
Acfer_1600	COG2217	Heavy metal translocating P-type atpase
Acfer_1604	COG2379	hydroxypyruvate reductase
Acfer_1605	COG0668	transmembrane transport
Acfer_1606	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Acfer_1607	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Acfer_1608	COG1605	Chorismate mutase
Acfer_1608	COG0077	Prephenate dehydratase
Acfer_1609	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Acfer_1611	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Acfer_1612	COG0287	Prephenate dehydrogenase
Acfer_1613	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Acfer_1615	COG0489	protein tyrosine kinase activity
Acfer_1617	COG0776	regulation of translation
Acfer_1618	COG3956	TIGRFAM MazG family protein
Acfer_1619	COG2244	polysaccharide biosynthetic process
Acfer_1620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Acfer_1621	COG1494	fructose-1,6-bisphosphatase
Acfer_1622	COG0504	CTP synthase activity
Acfer_1623	COG0018	arginyl-trna synthetase
Acfer_1625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Acfer_1627	COG0860	N-Acetylmuramoyl-L-alanine amidase
Acfer_1628	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Acfer_1628	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Acfer_1629	COG0736	holo-[acyl-carrier-protein] synthase activity
Acfer_1630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Acfer_1633	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Acfer_1634	COG4120	Belongs to the binding-protein-dependent transport system permease family
Acfer_1638	COG0501	Belongs to the peptidase M48B family
Acfer_1639	COG0420	3'-5' exonuclease activity
Acfer_1640	COG0419	ATPase involved in DNA repair
Acfer_1641	COG0602	queuosine metabolic process
Acfer_1643	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Acfer_1646	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Acfer_1648	COG4864	UPF0365 protein
Acfer_1652	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Acfer_1653	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Acfer_1654	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Acfer_1654	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Acfer_1655	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Acfer_1658	COG2990	Protein conserved in bacteria
Acfer_1662	COG1739	Uncharacterized protein family UPF0029
Acfer_1666	COG0497	DNA recombination
Acfer_1668	COG0497	DNA recombination
Acfer_1669	COG0497	DNA recombination
Acfer_1670	COG0497	DNA recombination
Acfer_1672	COG4372	Transposase
Acfer_1676	COG1137	ATPase activity
Acfer_1680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Acfer_1682	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Acfer_1684	COG1663	tetraacyldisaccharide 4'-kinase activity
Acfer_1685	COG1132	(ABC) transporter
Acfer_1686	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Acfer_1687	COG3494	Protein of unknown function (DUF1009)
Acfer_1688	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Acfer_1689	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Acfer_1689	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Acfer_1692	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Acfer_1696	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Acfer_1700	COG1127	ABC transporter
Acfer_1701	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Acfer_1702	COG0750	zinc metalloprotease
Acfer_1704	COG5434	Belongs to the glycosyl hydrolase 28 family
Acfer_1704	COG4632	Exopolysaccharide biosynthesis protein
Acfer_1705	COG1077	Cell shape determining protein MreB Mrl
Acfer_1706	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Acfer_1711	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Acfer_1712	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Acfer_1713	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Acfer_1714	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Acfer_1715	COG0356	it plays a direct role in the translocation of protons across the membrane
Acfer_1717	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Acfer_1718	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Acfer_1721	COG0534	Mate efflux family protein
Acfer_1722	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Acfer_1726	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Acfer_1727	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Acfer_1728	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Acfer_1729	COG0277	FAD linked oxidase domain protein
Acfer_1730	COG0590	tRNA wobble adenosine to inosine editing
Acfer_1731	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Acfer_1734	COG1408	metallophosphoesterase
Acfer_1735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Acfer_1740	COG0300	oxidoreductase activity
Acfer_1741	COG1247	-acetyltransferase
Acfer_1745	COG1301	dicarboxylic acid transport
Acfer_1746	COG2721	sulfolactate sulfo-lyase activity
Acfer_1747	COG2721	sulfolactate sulfo-lyase activity
Acfer_1749	COG2195	Cleaves the N-terminal amino acid of tripeptides
Acfer_1750	COG1288	antiporter activity
Acfer_1753	COG1827	regulation of RNA biosynthetic process
Acfer_1758	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Acfer_1760	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Acfer_1761	COG0154	amidase activity
Acfer_1762	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Acfer_1763	COG0626	cystathionine gamma-synthase activity
Acfer_1764	COG0473	3-isopropylmalate dehydrogenase activity
Acfer_1770	COG3210	domain, Protein
Acfer_1773	COG3210	domain, Protein
Acfer_1776	COG3210	domain, Protein
Acfer_1777	COG3210	domain, Protein
Acfer_1779	COG0751	glycine-tRNA ligase activity
Acfer_1780	COG0752	glycyl-tRNA synthetase alpha subunit
Acfer_1781	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Acfer_1782	COG0358	DNA primase activity
Acfer_1782	COG0305	Participates in initiation and elongation during chromosome replication
Acfer_1783	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Acfer_1784	COG0517	IMP dehydrogenase activity
Acfer_1785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Acfer_1785	COG0574	Belongs to the PEP-utilizing enzyme family
Acfer_1787	COG4139	cobalamin transport
Acfer_1790	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Acfer_1791	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Acfer_1792	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Acfer_1793	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Acfer_1796	COG1045	serine acetyltransferase
Acfer_1799	COG0561	phosphatase activity
Acfer_1801	COG0733	neurotransmitter:sodium symporter activity
Acfer_1802	COG0733	neurotransmitter:sodium symporter activity
Acfer_1804	COG1607	acyl-coa hydrolase
Acfer_1808	COG1328	CTP reductase activity
Acfer_1810	COG1288	antiporter activity
Acfer_1811	COG0583	DNA-binding transcription factor activity
Acfer_1812	COG0427	acetyl-CoA hydrolase
Acfer_1814	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Acfer_1815	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Acfer_1816	COG1924	4 iron, 4 sulfur cluster binding
Acfer_1817	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Acfer_1818	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Acfer_1819	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Acfer_1820	COG0617	tRNA 3'-terminal CCA addition
Acfer_1821	COG1530	ribonuclease E activity
Acfer_1824	COG0772	Belongs to the SEDS family
Acfer_1828	COG1077	Cell shape determining protein MreB Mrl
Acfer_1829	COG2003	Belongs to the UPF0758 family
Acfer_1830	COG0424	maF-like protein
Acfer_1834	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Acfer_1835	COG4770	biotin carboxylase activity
Acfer_1837	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Acfer_1838	COG0427	acetyl-CoA hydrolase
Acfer_1840	COG2172	sigma factor antagonist activity
Acfer_1845	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Acfer_1846	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Acfer_1848	COG0531	amino acid
Acfer_1849	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Acfer_1850	COG0646	methionine synthase
Acfer_1850	COG1410	methionine synthase
Acfer_1852	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Acfer_1853	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acfer_1854	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Acfer_1855	COG1687	branched-chain amino acid
Acfer_1856	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Acfer_1858	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Acfer_1862	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Acfer_1863	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Acfer_1864	COG1194	a g-specific adenine glycosylase
Acfer_1865	COG2816	NAD+ diphosphatase activity
Acfer_1866	COG2195	Cleaves the N-terminal amino acid of tripeptides
Acfer_1867	COG1984	allophanate hydrolase subunit 2
Acfer_1868	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Acfer_1869	COG1914	H( )-stimulated, divalent metal cation uptake system
Acfer_1870	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Acfer_1871	COG1914	H( )-stimulated, divalent metal cation uptake system
Acfer_1872	COG1196	nuclear chromosome segregation
Acfer_1873	COG1827	regulation of RNA biosynthetic process
Acfer_1874	COG0583	DNA-binding transcription factor activity
Acfer_1878	COG1136	(ABC) transporter
Acfer_1881	COG0704	Plays a role in the regulation of phosphate uptake
Acfer_1882	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Acfer_1883	COG0581	inorganic phosphate transmembrane transporter activity
Acfer_1885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Acfer_1888	COG0010	Belongs to the arginase family
Acfer_1889	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Acfer_1890	COG1982	Orn Lys Arg decarboxylase major
Acfer_1894	COG0488	(ABC) transporter
Acfer_1897	COG2221	Nitrite and sulphite reductase 4Fe-4S
Acfer_1898	COG0622	Phosphoesterase
Acfer_1901	COG0203	ribosomal protein L17
Acfer_1902	COG0202	RNA polymerase activity
Acfer_1903	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Acfer_1905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Acfer_1906	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Acfer_1908	COG0563	adenylate kinase activity
Acfer_1909	COG0201	protein transport
Acfer_1911	COG1841	ribosomal large subunit assembly
Acfer_1912	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Acfer_1913	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Acfer_1914	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Acfer_1915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Acfer_1916	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Acfer_1917	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Acfer_1918	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Acfer_1920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Acfer_1922	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Acfer_1923	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Acfer_1924	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Acfer_1926	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Acfer_1927	COG0089	rRNA binding
Acfer_1928	COG0088	Forms part of the polypeptide exit tunnel
Acfer_1929	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Acfer_1933	COG0049	tRNA binding
Acfer_1934	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Acfer_1935	COG1358	cellular component organization or biogenesis
Acfer_1940	COG0488	(ABC) transporter
Acfer_1941	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Acfer_1945	COG0582	viral genome integration into host DNA
Acfer_1953	COG1959	2 iron, 2 sulfur cluster binding
Acfer_1954	COG0493	'glutamate synthase
Acfer_1956	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Acfer_1957	COG2843	Capsule synthesis protein
Acfer_1958	COG0477	Major facilitator Superfamily
Acfer_1958	COG0477	Major facilitator Superfamily
Acfer_1961	COG0542	response to heat
Acfer_1963	COG0735	belongs to the Fur family
Acfer_1966	COG0583	DNA-binding transcription factor activity
Acfer_1967	COG0583	DNA-binding transcription factor activity
Acfer_1968	COG0473	3-isopropylmalate dehydrogenase activity
Acfer_1970	COG2706	6-phosphogluconolactonase activity
Acfer_1971	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Acfer_1972	COG0583	DNA-binding transcription factor activity
Acfer_1973	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Acfer_1974	COG2828	Protein conserved in bacteria
Acfer_1980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Acfer_1982	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Acfer_1983	COG0583	DNA-binding transcription factor activity
Acfer_1985	COG0446	pyridine nucleotide-disulphide oxidoreductase
Acfer_1986	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Acfer_1986	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Acfer_1987	COG0471	metal ion transport
Acfer_1988	COG1917	Cupin 2, conserved barrel domain protein
Acfer_1988	COG2207	Transcriptional regulator
Acfer_1990	COG0251	oxidation-reduction process
Acfer_1991	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Acfer_1992	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Acfer_1996	COG1301	dicarboxylic acid transport
Acfer_1997	COG2267	carboxylic ester hydrolase activity
Acfer_1999	COG3842	ATPase activity
Acfer_2000	COG1178	ABC-type Fe3 transport system permease component
Acfer_2001	COG3842	ATPase activity
Acfer_2004	COG0010	Belongs to the arginase family
Acfer_2006	COG1414	Transcriptional regulator
Acfer_2007	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acfer_2008	COG1473	amidohydrolase
Acfer_2011	COG0583	DNA-binding transcription factor activity
Acfer_2013	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Acfer_2015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Acfer_2016	COG4948	Mandelate Racemase Muconate Lactonizing
Acfer_2023	COG0583	DNA-binding transcription factor activity
Acfer_2028	COG0471	metal ion transport
Acfer_2028	COG0490	domain, Protein
Acfer_2029	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Acfer_2031	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Acfer_2032	COG0583	DNA-binding transcription factor activity
Acfer_2034	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Acfer_2035	COG1322	Protein conserved in bacteria
Acfer_2043	COG2195	Cleaves the N-terminal amino acid of tripeptides
Acfer_2044	COG2183	response to ionizing radiation
Acfer_2046	COG1122	ATPase activity
Acfer_2047	COG1122	ATPase activity
Acfer_2050	COG0071	Belongs to the small heat shock protein (HSP20) family
Acfer_2053	COG0114	fumarate hydratase activity
Acfer_2054	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Acfer_2057	COG0493	'glutamate synthase
Acfer_2061	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Acfer_2063	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Acfer_2067	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Acfer_2071	COG1475	DNA binding
Acfer_2072	COG1192	Involved in chromosome partitioning
Acfer_2073	COG2195	Cleaves the N-terminal amino acid of tripeptides
Acfer_2075	COG0357	Ribosomal RNA small subunit methyltransferase G
Acfer_2076	COG0445	tRNA wobble uridine modification
Acfer_2077	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Acfer_2078	COG1847	R3H domain protein
Acfer_2080	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Acfer_2081	COG0594	ribonuclease P activity
Acfer_2084	COG1473	amidohydrolase
Acfer_2086	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Acfer_2087	COG0252	asparaginase activity
Acfer_2091	COG5001	Diguanylate cyclase
Acfer_2091	COG3300	MHYT domain
Acfer_2092	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity