locus-tag	class	description
Acin_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Acin_0003	COG0592	DNA-directed DNA polymerase activity
Acin_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Acin_0007	COG0187	DNA topoisomerase II activity
Acin_0009	COG0730	response to heat
Acin_0010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Acin_0012	COG2801	Transposase and inactivated derivatives
Acin_0020	COG0436	Aminotransferase
Acin_0022	COG0489	protein tyrosine kinase activity
Acin_0024	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Acin_0026	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Acin_0028	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Acin_0029	COG1605	Chorismate mutase
Acin_0029	COG0077	Prephenate dehydratase
Acin_0031	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Acin_0032	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Acin_0035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Acin_0037	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Acin_0038	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Acin_0040	COG0583	DNA-binding transcription factor activity
Acin_0041	COG0028	Belongs to the TPP enzyme family
Acin_0047	COG0542	response to heat
Acin_0049	COG0710	3-dehydroquinate dehydratase activity
Acin_0050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Acin_0051	COG0668	transmembrane transport
Acin_0052	COG2379	hydroxypyruvate reductase
Acin_0071	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acin_0078	COG3189	MarR family transcriptional regulator
Acin_0080	COG1115	amino acid carrier protein
Acin_0081	COG0544	peptidyl-prolyl cis-trans isomerase activity
Acin_0082	COG0740	serine-type endopeptidase activity
Acin_0083	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Acin_0084	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Acin_0086	COG0494	nUDIX hydrolase
Acin_0091	COG2860	membrane
Acin_0093	COG1666	GTP binding
Acin_0095	COG0556	nucleotide-excision repair
Acin_0097	COG0322	excinuclease ABC activity
Acin_0098	COG1773	rubredoxin
Acin_0099	COG0561	phosphatase activity
Acin_0101	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Acin_0108	COG0440	acetolactate synthase activity
Acin_0109	COG0028	Belongs to the TPP enzyme family
Acin_0110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Acin_0113	COG0385	Bile acid
Acin_0118	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acin_0121	COG0803	Belongs to the bacterial solute-binding protein 9 family
Acin_0122	COG1121	(ABC) transporter
Acin_0123	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Acin_0126	COG0583	DNA-binding transcription factor activity
Acin_0127	COG2851	Citrate transporter
Acin_0137	COG0411	ABC transporter
Acin_0138	COG0410	ABC transporter
Acin_0141	COG1288	antiporter activity
Acin_0145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acin_0147	COG1691	(AIR) carboxylase
Acin_0154	COG1971	Probably functions as a manganese efflux pump
Acin_0155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Acin_0159	COG0360	Binds together with S18 to 16S ribosomal RNA
Acin_0161	COG0629	single-stranded DNA binding
Acin_0162	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Acin_0165	COG1131	(ABC) transporter
Acin_0166	COG0842	Transport permease protein
Acin_0167	COG0842	Transport permease protein
Acin_0169	COG0583	DNA-binding transcription factor activity
Acin_0171	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Acin_0173	COG2706	6-phosphogluconolactonase activity
Acin_0174	COG5016	pyruvate
Acin_0174	COG0511	ligase activity, forming carbon-carbon bonds
Acin_0177	COG1122	ATPase activity
Acin_0178	COG1122	ATPase activity
Acin_0181	COG1269	ATP hydrolysis coupled proton transport
Acin_0182	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Acin_0185	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
Acin_0186	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Acin_0192	COG0745	RESPONSE REGULATOR receiver
Acin_0193	COG5000	phosphorelay sensor kinase activity
Acin_0193	COG5002	protein histidine kinase activity
Acin_0196	COG2078	PFAM AMMECR1 domain protein
Acin_0196	COG3885	ferrous iron binding
Acin_0198	COG1573	uracil-dna glycosylase
Acin_0202	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
Acin_0202	COG2878	Part of a membrane complex involved in electron transport
Acin_0203	COG4657	Part of a membrane complex involved in electron transport
Acin_0204	COG4660	Part of a membrane complex involved in electron transport
Acin_0205	COG4659	FMN binding
Acin_0206	COG4658	electron transport chain
Acin_0207	COG4656	Part of a membrane complex involved in electron transport
Acin_0209	COG0791	NLP P60 protein
Acin_0210	COG2204	response regulator
Acin_0211	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Acin_0212	COG0772	Belongs to the SEDS family
Acin_0214	COG0768	penicillin binding
Acin_0215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Acin_0217	COG0318	PFAM AMP-dependent synthetase and ligase
Acin_0224	COG1966	Carbon starvation protein
Acin_0225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Acin_0226	COG3047	cAMP biosynthetic process
Acin_0226	COG2885	chlorophyll binding
Acin_0227	COG0277	FAD linked oxidase domain protein
Acin_0228	COG0405	Gamma-glutamyltransferase
Acin_0229	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Acin_0230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Acin_0234	COG2084	Dehydrogenase
Acin_0236	COG1176	ABC-type spermidine putrescine transport system, permease component I
Acin_0237	COG3842	ATPase activity
Acin_0238	COG0251	oxidation-reduction process
Acin_0241	COG2801	Transposase and inactivated derivatives
Acin_0243	COG0010	Belongs to the arginase family
Acin_0244	COG1414	Transcriptional regulator
Acin_0249	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Acin_0252	COG1704	LemA family
Acin_0256	COG2801	Transposase and inactivated derivatives
Acin_0259	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Acin_0260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Acin_0261	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Acin_0263	COG1136	(ABC) transporter
Acin_0264	COG1136	(ABC) transporter
Acin_0264	COG0577	efflux transmembrane transporter activity
Acin_0266	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Acin_0267	COG1914	H( )-stimulated, divalent metal cation uptake system
Acin_0268	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Acin_0269	COG1984	allophanate hydrolase subunit 2
Acin_0272	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Acin_0274	COG1194	a g-specific adenine glycosylase
Acin_0275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Acin_0277	COG2116	formate transmembrane transporter activity
Acin_0282	COG3829	transcription factor binding
Acin_0284	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Acin_0285	COG2986	histidine ammonia-lyase
Acin_0287	COG2056	Na+-H+ antiporter family
Acin_0289	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Acin_0293	COG2172	sigma factor antagonist activity
Acin_0295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Acin_0297	COG4770	biotin carboxylase activity
Acin_0298	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Acin_0305	COG2003	Belongs to the UPF0758 family
Acin_0306	COG1077	Cell shape determining protein MreB Mrl
Acin_0310	COG0772	Belongs to the SEDS family
Acin_0313	COG1530	ribonuclease E activity
Acin_0314	COG0617	tRNA 3'-terminal CCA addition
Acin_0316	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Acin_0317	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Acin_0318	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Acin_0319	COG1924	4 iron, 4 sulfur cluster binding
Acin_0320	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Acin_0321	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Acin_0322	COG1328	CTP reductase activity
Acin_0324	COG1473	amidohydrolase
Acin_0327	COG1607	acyl-coa hydrolase
Acin_0329	COG0733	neurotransmitter:sodium symporter activity
Acin_0332	COG0561	phosphatase activity
Acin_0333	COG2707	UPF0756 membrane protein
Acin_0334	COG1376	ErfK ybiS ycfS ynhG family protein
Acin_0336	COG0735	belongs to the Fur family
Acin_0337	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Acin_0339	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Acin_0340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Acin_0342	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Acin_0343	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
Acin_0344	COG2801	Transposase and inactivated derivatives
Acin_0346	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Acin_0347	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Acin_0348	COG0242	peptide deformylase activity
Acin_0349	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Acin_0351	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Acin_0351	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Acin_0352	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Acin_0353	COG0631	protein serine/threonine phosphatase activity
Acin_0354	COG0515	serine threonine protein kinase
Acin_0354	COG2815	serine threonine protein kinase
Acin_0356	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Acin_0360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Acin_0360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Acin_0362	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Acin_0363	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Acin_0366	COG1418	mRNA catabolic process
Acin_0371	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Acin_0374	COG1151	hydroxylamine reductase activity
Acin_0377	COG2610	gluconate transmembrane transporter activity
Acin_0378	COG0396	ATPase activity
Acin_0379	COG0719	Fe-S assembly protein
Acin_0381	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Acin_0382	COG0822	iron-sulfur transferase activity
Acin_0383	COG1185	polyribonucleotide nucleotidyltransferase activity
Acin_0386	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Acin_0387	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Acin_0389	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Acin_0391	COG0351	phosphomethylpyrimidine kinase
Acin_0392	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Acin_0393	COG0352	thiamine-phosphate diphosphorylase activity
Acin_0395	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Acin_0396	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Acin_0397	COG0228	four-way junction DNA binding
Acin_0398	COG1837	Belongs to the UPF0109 family
Acin_0400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Acin_0401	COG0336	Belongs to the RNA methyltransferase TrmD family
Acin_0402	COG0335	large ribosomal subunit rRNA binding
Acin_0404	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Acin_0405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Acin_0406	COG0792	nuclease activity
Acin_0413	COG0572	uridine kinase
Acin_0414	COG0436	Aminotransferase
Acin_0418	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Acin_0420	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Acin_0427	COG1122	ATPase activity
Acin_0429	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Acin_0430	COG0101	tRNA pseudouridine synthase activity
Acin_0431	COG4771	TonB-dependent receptor
Acin_0433	COG1121	(ABC) transporter
Acin_0434	COG0811	peptide transport
Acin_0439	COG1268	BioY protein
Acin_0440	COG0183	Belongs to the thiolase family
Acin_0444	COG1720	tRNA m6t6A37 methyltransferase activity
Acin_0448	COG2731	YhcH YjgK YiaL family protein
Acin_0459	COG0583	DNA-binding transcription factor activity
Acin_0460	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Acin_0461	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Acin_0463	COG0602	queuosine metabolic process
Acin_0467	COG4948	Mandelate Racemase Muconate Lactonizing
Acin_0471	COG3584	3D domain protein
Acin_0471	COG1388	LysM domain
Acin_0473	COG1960	acyl-CoA dehydrogenase activity
Acin_0475	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Acin_0478	COG1214	PFAM Peptidase M22, glycoprotease
Acin_0484	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Acin_0485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Acin_0487	COG1979	alcohol dehydrogenase
Acin_0488	COG0426	domain, Protein
Acin_0489	COG1960	acyl-CoA dehydrogenase activity
Acin_0495	COG0024	Methionine aminopeptidase
Acin_0498	COG2252	PERMEase
Acin_0499	COG0037	tRNA processing
Acin_0501	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Acin_0504	COG1966	Carbon starvation protein
Acin_0505	COG0039	L-malate dehydrogenase activity
Acin_0506	COG0179	Fumarylacetoacetate (FAA) hydrolase
Acin_0508	COG3875	lactate racemase activity
Acin_0512	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Acin_0513	COG1702	phosphate starvation-inducible protein PhoH
Acin_0514	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Acin_0516	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Acin_0517	COG1253	flavin adenine dinucleotide binding
Acin_0520	COG0708	Exodeoxyribonuclease III
Acin_0522	COG0494	nUDIX hydrolase
Acin_0524	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Acin_0527	COG1555	photosystem II stabilization
Acin_0527	COG1596	polysaccharide export
Acin_0528	COG0658	competence protein
Acin_0528	COG2333	competence protein COMEC
Acin_0530	COG0786	glutamate:sodium symporter activity
Acin_0535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Acin_0536	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Acin_0537	COG1802	Transcriptional regulator
Acin_0538	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Acin_0539	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Acin_0540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Acin_0543	COG1760	l-serine dehydratase
Acin_0544	COG1760	l-serine dehydratase
Acin_0545	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Acin_0547	COG0254	rRNA binding
Acin_0548	COG3872	metal-dependent enzyme
Acin_0549	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Acin_0550	COG2890	protein-(glutamine-N5) methyltransferase activity
Acin_0551	COG0009	L-threonylcarbamoyladenylate synthase
Acin_0553	COG0698	ribose 5-phosphate isomerase
Acin_0554	COG4475	Protein of unknown function (DUF436)
Acin_0555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Acin_0556	COG2131	deaminase
Acin_0560	COG0473	3-isopropylmalate dehydrogenase activity
Acin_0564	COG0589	response to stress
Acin_0565	COG0589	response to stress
Acin_0566	COG0589	response to stress
Acin_0567	COG0589	response to stress
Acin_0568	COG0525	valine-tRNA ligase activity
Acin_0569	COG0285	dihydrofolate synthase activity
Acin_0573	COG3052	prosthetic group binding
Acin_0574	COG0583	DNA-binding transcription factor activity
Acin_0577	COG2851	Citrate transporter
Acin_0580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Acin_0581	COG1177	transmembrane transport
Acin_0582	COG1176	ABC-type spermidine putrescine transport system, permease component I
Acin_0587	COG1733	regulation of RNA biosynthetic process
Acin_0588	COG2195	Cleaves the N-terminal amino acid of tripeptides
Acin_0593	COG1288	antiporter activity
Acin_0594	COG2195	Cleaves the N-terminal amino acid of tripeptides
Acin_0595	COG0583	DNA-binding transcription factor activity
Acin_0597	COG2706	6-phosphogluconolactonase activity
Acin_0599	COG0583	DNA-binding transcription factor activity
Acin_0601	COG0778	Nitroreductase
Acin_0605	COG0583	DNA-binding transcription factor activity
Acin_0607	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Acin_0608	COG1846	Transcriptional regulator
Acin_0610	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Acin_0613	COG2195	Cleaves the N-terminal amino acid of tripeptides
Acin_0614	COG1304	FMN binding
Acin_0617	COG1414	Transcriptional regulator
Acin_0621	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Acin_0621	COG0674	pyruvate-flavodoxin oxidoreductase activity
Acin_0625	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Acin_0626	COG1132	(ABC) transporter
Acin_0627	COG1663	tetraacyldisaccharide 4'-kinase activity
Acin_0628	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Acin_0629	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Acin_0631	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Acin_0635	COG1137	ATPase activity
Acin_0637	COG4443	Transcriptional Coactivator p15 (PC4)
Acin_0639	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Acin_0641	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Acin_0641	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Acin_0642	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Acin_0643	COG1490	D-aminoacyl-tRNA deacylase activity
Acin_0645	COG0628	permease
Acin_0646	COG0124	histidyl-tRNA synthetase
Acin_0647	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Acin_0649	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Acin_0650	COG0564	pseudouridine synthase activity
Acin_0652	COG1196	nuclear chromosome segregation
Acin_0653	COG0552	protein localization to endoplasmic reticulum
Acin_0655	COG3118	belongs to the thioredoxin family
Acin_0658	COG2968	Membrane
Acin_0659	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Acin_0662	COG3468	outer membrane autotransporter barrel domain protein
Acin_0668	COG3468	outer membrane autotransporter barrel domain protein
Acin_0682	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Acin_0683	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Acin_0685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Acin_0686	COG0640	Transcriptional regulator
Acin_0690	COG2814	Major facilitator Superfamily
Acin_0692	COG2226	methyltransferase
Acin_0693	COG1191	sigma factor activity
Acin_0698	COG1484	DNA-dependent DNA replication
Acin_0701	COG2814	Major facilitator Superfamily
Acin_0704	COG1846	Transcriptional regulator
Acin_0705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Acin_0707	COG2848	UPF0210 protein
Acin_0708	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Acin_0711	COG2207	Transcriptional regulator
Acin_0716	COG1115	amino acid carrier protein
Acin_0717	COG1473	amidohydrolase
Acin_0719	COG0183	Belongs to the thiolase family
Acin_0721	COG1250	3-hydroxyacyl-CoA dehydrogenase
Acin_0722	COG1024	Enoyl-CoA hydratase
Acin_0723	COG1362	aminopeptidase activity
Acin_0724	COG1012	belongs to the aldehyde dehydrogenase family
Acin_0727	COG1739	Uncharacterized protein family UPF0029
Acin_0730	COG2990	Protein conserved in bacteria
Acin_0732	COG0497	DNA recombination
Acin_0733	COG0497	DNA recombination
Acin_0740	COG2964	Protein conserved in bacteria
Acin_0743	COG0488	(ABC) transporter
Acin_0752	COG1592	Rubrerythrin
Acin_0755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Acin_0755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Acin_0759	COG0217	transcriptional regulatory protein
Acin_0760	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Acin_0763	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Acin_0764	COG2385	sporulation resulting in formation of a cellular spore
Acin_0765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Acin_0769	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Acin_0770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Acin_0772	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Acin_0773	COG0736	holo-[acyl-carrier-protein] synthase activity
Acin_0774	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Acin_0774	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Acin_0777	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Acin_0779	COG0018	arginyl-trna synthetase
Acin_0780	COG0504	CTP synthase activity
Acin_0781	COG1494	fructose-1,6-bisphosphatase
Acin_0782	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Acin_0783	COG2244	polysaccharide biosynthetic process
Acin_0784	COG3956	TIGRFAM MazG family protein
Acin_0785	COG0776	regulation of translation
Acin_0787	COG1098	S1 RNA binding domain
Acin_0789	COG0037	tRNA processing
Acin_0790	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Acin_0790	COG0037	tRNA processing
Acin_0791	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Acin_0792	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Acin_0792	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Acin_0795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Acin_0797	COG2217	Heavy metal translocating P-type atpase
Acin_0798	COG4771	TonB-dependent receptor
Acin_0800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Acin_0801	COG1120	ATPase activity
Acin_0804	COG1132	(ABC) transporter
Acin_0805	COG0811	peptide transport
Acin_0810	COG4771	TonB-dependent receptor
Acin_0818	COG3706	GGDEF domain
Acin_0818	COG2203	Gaf domain
Acin_0818	COG4251	negative regulation of phosphorylation
Acin_0818	COG5001	Diguanylate cyclase
Acin_0824	COG0726	polysaccharide deacetylase
Acin_0829	COG3384	dioxygenase
Acin_0830	COG1733	regulation of RNA biosynthetic process
Acin_0831	COG1304	FMN binding
Acin_0832	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Acin_0833	COG0569	domain protein
Acin_0834	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Acin_0835	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Acin_0836	COG1937	Protein conserved in bacteria
Acin_0842	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Acin_0843	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Acin_0843	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Acin_0844	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Acin_0845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Acin_0848	COG4443	Transcriptional Coactivator p15 (PC4)
Acin_0849	COG4372	Transposase
Acin_0854	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Acin_0855	COG1799	cell septum assembly
Acin_0856	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Acin_0859	COG1196	nuclear chromosome segregation
Acin_0866	COG1464	Belongs to the NlpA lipoprotein family
Acin_0867	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acin_0868	COG0531	amino acid
Acin_0869	COG1362	aminopeptidase activity
Acin_0870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Acin_0874	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Acin_0875	COG0786	glutamate:sodium symporter activity
Acin_0877	COG1823	symporter activity
Acin_0880	COG1136	(ABC) transporter
Acin_0882	COG1785	Belongs to the alkaline phosphatase family
Acin_0884	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Acin_0885	COG2011	ABC-type metal ion transport system permease component
Acin_0886	COG4496	protein, YerC YecD
Acin_0887	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Acin_0890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Acin_0891	COG0131	Imidazoleglycerol-phosphate dehydratase
Acin_0892	COG0131	Imidazoleglycerol-phosphate dehydratase
Acin_0893	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Acin_0895	COG0107	imidazoleglycerol-phosphate synthase activity
Acin_0896	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Acin_0896	COG0140	phosphoribosyl-ATP diphosphatase activity
Acin_0897	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Acin_0901	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Acin_0902	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Acin_0904	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Acin_0905	COG1970	mechanosensitive ion channel activity
Acin_0906	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Acin_0907	COG0427	acetyl-CoA hydrolase
Acin_0908	COG0494	nUDIX hydrolase
Acin_0910	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Acin_0912	COG1193	negative regulation of DNA recombination
Acin_0913	COG0268	Binds directly to 16S ribosomal RNA
Acin_0914	COG0481	GTPase activity
Acin_0916	COG0471	metal ion transport
Acin_0916	COG3273	potassium ion transport
Acin_0922	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Acin_0925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Acin_0927	COG0484	heat shock protein binding
Acin_0928	COG0138	bifunctional purine biosynthesis protein purh
Acin_0930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Acin_0933	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Acin_0935	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Acin_0937	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Acin_0939	COG4974	Belongs to the 'phage' integrase family
Acin_0941	COG0501	Belongs to the peptidase M48B family
Acin_0944	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Acin_0946	COG0515	serine threonine protein kinase
Acin_0949	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Acin_0950	COG3481	metal-dependent phosphohydrolase, HD sub domain
Acin_0956	COG4956	integral membrane protein (PIN domain superfamily)
Acin_0957	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Acin_0957	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Acin_0958	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Acin_0958	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Acin_0959	COG0215	cysteine-tRNA ligase activity
Acin_0960	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Acin_0964	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Acin_0966	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Acin_0969	COG0492	ferredoxin-NADP+ reductase activity
Acin_0969	COG3118	belongs to the thioredoxin family
Acin_0970	COG0463	Glycosyl transferase, family 2
Acin_0974	COG4977	sequence-specific DNA binding
Acin_0974	COG1917	Cupin 2, conserved barrel domain protein
Acin_0978	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
Acin_0979	COG1518	maintenance of DNA repeat elements
Acin_0980	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Acin_0985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Acin_0986	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acin_0986	COG0072	phenylalanine-tRNA ligase activity
Acin_0988	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Acin_0989	COG0562	UDP-galactopyranose mutase
Acin_0991	COG3475	LICD family
Acin_0992	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Acin_0993	COG2801	Transposase and inactivated derivatives
Acin_0994	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Acin_0996	COG3475	LICD family
Acin_0997	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Acin_1004	COG1088	dTDP-glucose 4,6-dehydratase activity
Acin_1006	COG1216	Glycosyl transferase, family 2
Acin_1007	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Acin_1008	COG1088	dTDP-glucose 4,6-dehydratase activity
Acin_1011	COG1216	Glycosyl transferase, family 2
Acin_1016	COG1309	transcriptional regulator
Acin_1019	COG2852	Protein conserved in bacteria
Acin_1020	COG2852	Protein conserved in bacteria
Acin_1021	COG0540	Belongs to the ATCase OTCase family
Acin_1022	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Acin_1023	COG0505	Belongs to the CarA family
Acin_1024	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Acin_1025	COG0543	2 iron, 2 sulfur cluster binding
Acin_1026	COG0167	dihydroorotate dehydrogenase activity
Acin_1027	COG0284	orotidine-5'-phosphate decarboxylase activity
Acin_1028	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Acin_1029	COG1982	Orn Lys Arg decarboxylase major
Acin_1030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Acin_1032	COG1774	PSP1 C-terminal conserved region
Acin_1033	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Acin_1034	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Acin_1035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acin_1035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Acin_1036	COG0084	hydrolase, TatD family'
Acin_1037	COG1388	LysM domain
Acin_1037	COG3584	3D domain protein
Acin_1039	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Acin_1042	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Acin_1043	COG0459	protein refolding
Acin_1044	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Acin_1047	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Acin_1048	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Acin_1049	COG1228	amidohydrolase
Acin_1052	COG0517	IMP dehydrogenase activity
Acin_1052	COG4175	Glycine betaine
Acin_1054	COG0656	L-ascorbic acid biosynthetic process
Acin_1056	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Acin_1057	COG0573	inorganic phosphate transmembrane transporter activity
Acin_1058	COG0581	inorganic phosphate transmembrane transporter activity
Acin_1059	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Acin_1060	COG0704	Plays a role in the regulation of phosphate uptake
Acin_1061	COG1687	branched-chain amino acid
Acin_1062	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Acin_1063	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Acin_1064	COG2852	Protein conserved in bacteria
Acin_1066	COG0534	Mate efflux family protein
Acin_1069	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Acin_1070	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Acin_1071	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Acin_1072	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Acin_1073	COG0138	bifunctional purine biosynthesis protein purh
Acin_1074	COG0151	Belongs to the GarS family
Acin_1075	COG0517	IMP dehydrogenase activity
Acin_1075	COG0516	GMP reductase activity
Acin_1078	COG2357	RelA SpoT domain protein
Acin_1086	COG0511	ligase activity, forming carbon-carbon bonds
Acin_1086	COG5016	pyruvate
Acin_1089	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Acin_1089	COG0674	pyruvate-flavodoxin oxidoreductase activity
Acin_1089	COG1013	pyruvate-flavodoxin oxidoreductase activity
Acin_1089	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Acin_1091	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Acin_1092	COG0280	phosphate acetyltransferase
Acin_1094	COG3426	butyrate kinase activity
Acin_1095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Acin_1098	COG0786	glutamate:sodium symporter activity
Acin_1102	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Acin_1103	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Acin_1104	COG1570	exodeoxyribonuclease VII activity
Acin_1105	COG1722	exodeoxyribonuclease VII activity
Acin_1107	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Acin_1108	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Acin_1109	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Acin_1111	COG0497	DNA recombination
Acin_1112	COG0494	nUDIX hydrolase
Acin_1113	COG2359	stage V sporulation protein S
Acin_1116	COG1116	anion transmembrane transporter activity
Acin_1117	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Acin_1123	COG0191	fructose-bisphosphate aldolase activity
Acin_1124	COG0564	pseudouridine synthase activity
Acin_1126	COG0756	dUTP diphosphatase activity
Acin_1128	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Acin_1129	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Acin_1130	COG0527	aspartate kinase activity
Acin_1131	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Acin_1132	COG0613	PHP domain protein
Acin_1134	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Acin_1136	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Acin_1138	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Acin_1139	COG1674	ftsk spoiiie
Acin_1140	COG1426	Protein conserved in bacteria
Acin_1141	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Acin_1142	COG1058	Belongs to the CinA family
Acin_1142	COG1546	Belongs to the CinA family
Acin_1143	COG0513	Belongs to the DEAD box helicase family
Acin_1144	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Acin_1145	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Acin_1146	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Acin_1149	COG0402	S-adenosylhomocysteine deaminase activity
Acin_1150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Acin_1152	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acin_1158	COG0688	phosphatidylethanolamine metabolic process
Acin_1160	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Acin_1161	COG0083	homoserine kinase activity
Acin_1162	COG0460	homoserine dehydrogenase
Acin_1163	COG4492	Belongs to the UPF0735 family
Acin_1165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Acin_1166	COG1160	GTP binding
Acin_1168	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Acin_1168	COG0539	negative regulation of cytoplasmic translation
Acin_1170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Acin_1171	COG2081	HI0933 family
Acin_1172	COG1187	pseudouridine synthase activity
Acin_1173	COG1187	pseudouridine synthase activity
Acin_1174	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Acin_1176	COG1994	Peptidase M50
Acin_1177	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
Acin_1178	COG4974	Belongs to the 'phage' integrase family
Acin_1180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Acin_1181	COG0758	DNA mediated transformation
Acin_1183	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Acin_1184	COG1489	DNA binding
Acin_1187	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Acin_1191	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Acin_1192	COG0006	proline dipeptidase activity
Acin_1194	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Acin_1196	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Acin_1197	COG4472	Bacterial protein of unknown function (DUF965)
Acin_1199	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Acin_1200	COG0436	Aminotransferase
Acin_1201	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Acin_1202	COG0473	3-isopropylmalate dehydrogenase activity
Acin_1205	COG0583	DNA-binding transcription factor activity
Acin_1206	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Acin_1207	COG2033	superoxide reductase activity
Acin_1208	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Acin_1209	COG0557	exoribonuclease II activity
Acin_1241	COG1783	phage Terminase large subunit
Acin_1252	COG3723	Recombinational DNA repair protein, rece pathway
Acin_1253	COG5377	YqaJ viral recombinase family
Acin_1268	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Acin_1269	COG0385	Bile acid
Acin_1270	COG1250	3-hydroxyacyl-CoA dehydrogenase
Acin_1273	COG0604	alcohol dehydrogenase
Acin_1274	COG0251	oxidation-reduction process
Acin_1276	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acin_1278	COG3344	reverse transcriptase
Acin_1280	COG1301	dicarboxylic acid transport
Acin_1282	COG0583	DNA-binding transcription factor activity
Acin_1285	COG0583	DNA-binding transcription factor activity
Acin_1286	COG1074	ATP-dependent DNA helicase activity
Acin_1288	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Acin_1289	COG3679	Belongs to the UPF0342 family
Acin_1291	COG3850	Histidine kinase
Acin_1291	COG5002	protein histidine kinase activity
Acin_1292	COG0745	RESPONSE REGULATOR receiver
Acin_1304	COG1690	Belongs to the RtcB family
Acin_1309	COG2801	Transposase and inactivated derivatives
Acin_1310	COG2367	Beta-lactamase
Acin_1320	COG0860	N-Acetylmuramoyl-L-alanine amidase
Acin_1326	COG5301	cellulose 1,4-beta-cellobiosidase activity
Acin_1328	COG3299	homolog of phage Mu protein gp47
Acin_1344	COG0740	serine-type endopeptidase activity
Acin_1345	COG4695	Portal protein
Acin_1360	COG3646	Phage regulatory protein
Acin_1360	COG3645	SOS response
Acin_1370	COG3299	homolog of phage Mu protein gp47
Acin_1386	COG1783	phage Terminase large subunit
Acin_1396	COG1061	Type III restriction enzyme res subunit
Acin_1406	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Acin_1407	COG1592	Rubrerythrin
Acin_1407	COG1773	rubredoxin
Acin_1408	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Acin_1409	COG2217	Heavy metal translocating P-type atpase
Acin_1414	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Acin_1415	COG2040	homocysteine
Acin_1416	COG1115	amino acid carrier protein
Acin_1424	COG2801	Transposase and inactivated derivatives
Acin_1425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Acin_1425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Acin_1425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Acin_1426	COG1105	Belongs to the carbohydrate kinase PfkB family
Acin_1429	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Acin_1433	COG1342	Belongs to the UPF0251 family
Acin_1436	COG2814	Major facilitator Superfamily
Acin_1440	COG0667	Aldo Keto reductase
Acin_1445	COG1131	(ABC) transporter
Acin_1447	COG0667	Aldo Keto reductase
Acin_1449	COG0519	Catalyzes the synthesis of GMP from XMP
Acin_1455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Acin_1457	COG1469	GTP cyclohydrolase I activity
Acin_1458	COG0720	synthase
Acin_1459	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Acin_1461	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Acin_1462	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Acin_1471	COG0583	DNA-binding transcription factor activity
Acin_1473	COG0640	Transcriptional regulator
Acin_1474	COG0346	lactoylglutathione lyase activity
Acin_1476	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Acin_1479	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Acin_1482	COG0126	phosphoglycerate kinase activity
Acin_1482	COG0149	triose-phosphate isomerase activity
Acin_1485	COG1301	dicarboxylic acid transport
Acin_1486	COG1741	Belongs to the pirin family
Acin_1488	COG0733	neurotransmitter:sodium symporter activity
Acin_1494	COG0697	spore germination
Acin_1499	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Acin_1504	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Acin_1505	COG1758	RNA polymerase activity
Acin_1506	COG0194	GDP metabolic process
Acin_1507	COG2052	Domain of unknown function (DUF370)
Acin_1508	COG1561	YicC-like family, N-terminal region
Acin_1511	COG2801	Transposase and inactivated derivatives
Acin_1517	COG2165	general secretion pathway protein
Acin_1520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Acin_1521	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Acin_1522	COG3856	small basic protein
Acin_1525	COG1181	Belongs to the D-alanine--D-alanine ligase family
Acin_1526	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Acin_1527	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Acin_1528	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Acin_1529	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Acin_1530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Acin_1533	COG4839	cell division protein FtsL
Acin_1534	COG0275	rRNA processing
Acin_1535	COG2001	Belongs to the MraZ family
Acin_1539	COG2721	sulfolactate sulfo-lyase activity
Acin_1540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Acin_1544	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Acin_1548	COG1126	abc transporter atp-binding protein
Acin_1549	COG0765	amino acid transport
Acin_1550	COG0765	amino acid transport
Acin_1551	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acin_1552	COG2079	MmgE PrpD family protein
Acin_1554	COG0622	Phosphoesterase
Acin_1556	COG4336	lyase activity
Acin_1559	COG0534	Mate efflux family protein
Acin_1561	COG0655	NAD(P)H dehydrogenase (quinone) activity
Acin_1562	COG0427	acetyl-CoA hydrolase
Acin_1565	COG0129	dihydroxy-acid dehydratase activity
Acin_1567	COG1013	pyruvate-flavodoxin oxidoreductase activity
Acin_1568	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Acin_1568	COG0674	pyruvate-flavodoxin oxidoreductase activity
Acin_1570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Acin_1571	COG2610	gluconate transmembrane transporter activity
Acin_1572	COG4948	Mandelate Racemase Muconate Lactonizing
Acin_1573	COG0583	DNA-binding transcription factor activity
Acin_1576	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Acin_1577	COG0390	transport system, permease component
Acin_1578	COG2801	Transposase and inactivated derivatives
Acin_1580	COG1120	ATPase activity
Acin_1582	COG1473	amidohydrolase
Acin_1584	COG0196	riboflavin kinase activity
Acin_1585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Acin_1586	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Acin_1587	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Acin_1588	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Acin_1588	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Acin_1589	COG1358	cellular component organization or biogenesis
Acin_1590	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Acin_1591	COG0195	Participates in both transcription termination and antitermination
Acin_1598	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Acin_1604	COG1285	pathogenesis
Acin_1605	COG0442	prolyl-tRNA aminoacylation
Acin_1606	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Acin_1607	COG0750	zinc metalloprotease
Acin_1608	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Acin_1609	COG0575	Belongs to the CDS family
Acin_1610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Acin_1611	COG0233	cytoplasmic translational termination
Acin_1612	COG0528	UMP kinase activity
Acin_1613	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Acin_1614	COG0052	Belongs to the universal ribosomal protein uS2 family
Acin_1616	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Acin_1618	COG0571	ribonuclease III activity
Acin_1619	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Acin_1621	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Acin_1622	COG1028	Short-chain dehydrogenase reductase Sdr
Acin_1623	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Acin_1624	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Acin_1625	COG0416	fatty acid biosynthetic process
Acin_1626	COG2030	dehydratase
Acin_1627	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Acin_1629	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Acin_1630	COG1323	Belongs to the UPF0348 family
Acin_1634	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Acin_1635	COG0742	ribosomal rna small subunit methyltransferase
Acin_1638	COG0450	alkyl hydroperoxide reductase
Acin_1644	COG1610	YqeY-like protein
Acin_1645	COG0537	adenosine 5'-monophosphoramidase activity
Acin_1646	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Acin_1647	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Acin_1648	COG2264	protein methyltransferase activity
Acin_1651	COG0569	domain protein
Acin_1658	COG2086	electron transfer activity
Acin_1662	COG3326	Membrane
Acin_1667	COG1253	flavin adenine dinucleotide binding
Acin_1670	COG4864	UPF0365 protein
Acin_1676	COG4120	Belongs to the binding-protein-dependent transport system permease family
Acin_1679	COG0501	Belongs to the peptidase M48B family
Acin_1682	COG0419	ATPase involved in DNA repair
Acin_1685	COG2205	protein histidine kinase activity
Acin_1686	COG0745	RESPONSE REGULATOR receiver
Acin_1690	COG2239	Acts as a magnesium transporter
Acin_1694	COG0534	Mate efflux family protein
Acin_1697	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Acin_1698	COG1464	Belongs to the NlpA lipoprotein family
Acin_1699	COG0281	malic enzyme
Acin_1701	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Acin_1704	COG0824	Thioesterase
Acin_1705	COG3859	Proton-coupled thiamine transporter YuaJ
Acin_1706	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Acin_1707	COG2205	protein histidine kinase activity
Acin_1707	COG0784	Response regulator, receiver
Acin_1707	COG2198	Histidine kinase
Acin_1708	COG0793	Belongs to the peptidase S41A family
Acin_1708	COG3409	Peptidoglycan-binding domain 1 protein
Acin_1710	COG2177	Part of the ABC transporter FtsEX involved in
Acin_1711	COG2884	Cell division ATP-binding protein ftsE
Acin_1714	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Acin_1716	COG0653	protein targeting
Acin_1718	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Acin_1720	COG0765	amino acid transport
Acin_1721	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acin_1723	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acin_1724	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acin_1725	COG0784	Response regulator, receiver
Acin_1725	COG3437	response regulator, receiver
Acin_1728	COG0519	Catalyzes the synthesis of GMP from XMP
Acin_1737	COG0583	DNA-binding transcription factor activity
Acin_1740	COG0583	DNA-binding transcription factor activity
Acin_1742	COG0300	oxidoreductase activity
Acin_1743	COG1028	Short-chain dehydrogenase reductase Sdr
Acin_1744	COG1073	alpha beta
Acin_1745	COG2272	Belongs to the type-B carboxylesterase lipase family
Acin_1746	COG1979	alcohol dehydrogenase
Acin_1756	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Acin_1757	COG1827	regulation of RNA biosynthetic process
Acin_1763	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acin_1765	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Acin_1767	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Acin_1768	COG1560	Kdo2-lipid A biosynthetic process
Acin_1774	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Acin_1778	COG1127	ABC transporter
Acin_1779	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Acin_1783	COG1077	Cell shape determining protein MreB Mrl
Acin_1784	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Acin_1789	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Acin_1790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Acin_1792	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Acin_1792	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Acin_1793	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Acin_1794	COG0356	it plays a direct role in the translocation of protons across the membrane
Acin_1796	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Acin_1797	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Acin_1802	COG0534	Mate efflux family protein
Acin_1804	COG1597	lipid kinase activity
Acin_1808	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Acin_1809	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Acin_1812	COG0277	FAD linked oxidase domain protein
Acin_1813	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Acin_1815	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Acin_1816	COG0590	tRNA wobble adenosine to inosine editing
Acin_1848	COG0756	dUTP diphosphatase activity
Acin_1860	COG0582	viral genome integration into host DNA
Acin_1861	COG0583	DNA-binding transcription factor activity
Acin_1862	COG2059	Chromate
Acin_1867	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Acin_1868	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Acin_1869	COG1028	Short-chain dehydrogenase reductase Sdr
Acin_1874	COG1196	nuclear chromosome segregation
Acin_1891	COG0860	N-Acetylmuramoyl-L-alanine amidase
Acin_1917	COG0740	serine-type endopeptidase activity
Acin_1922	COG4626	Terminase
Acin_1922	COG1802	Transcriptional regulator
Acin_1927	COG1475	DNA binding
Acin_1944	COG1196	nuclear chromosome segregation
Acin_1950	COG0860	N-Acetylmuramoyl-L-alanine amidase
Acin_1957	COG5301	cellulose 1,4-beta-cellobiosidase activity
Acin_1959	COG3299	homolog of phage Mu protein gp47
Acin_1975	COG0740	serine-type endopeptidase activity
Acin_1976	COG4695	Portal protein
Acin_1996	COG3646	Phage regulatory protein
Acin_1996	COG3645	SOS response
Acin_2009	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Acin_2010	COG1733	regulation of RNA biosynthetic process
Acin_2011	COG2910	NAD(P)H-binding
Acin_2019	COG1979	alcohol dehydrogenase
Acin_2020	COG3829	transcription factor binding
Acin_2022	COG2207	Transcriptional regulator
Acin_2024	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Acin_2025	COG1882	Formate acetyltransferase
Acin_2029	COG1115	amino acid carrier protein
Acin_2032	COG0674	pyruvate-flavodoxin oxidoreductase activity
Acin_2032	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Acin_2032	COG1013	pyruvate-flavodoxin oxidoreductase activity
Acin_2032	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Acin_2036	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Acin_2036	COG0493	'glutamate synthase
Acin_2039	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Acin_2040	COG5002	protein histidine kinase activity
Acin_2041	COG0745	RESPONSE REGULATOR receiver
Acin_2042	COG0280	phosphate acetyltransferase
Acin_2048	COG1301	dicarboxylic acid transport
Acin_2049	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Acin_2050	COG0251	oxidation-reduction process
Acin_2063	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Acin_2064	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Acin_2065	COG3858	chitin binding
Acin_2066	COG1227	inorganic diphosphatase activity
Acin_2067	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Acin_2069	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Acin_2070	COG1473	amidohydrolase
Acin_2074	COG0165	Argininosuccinate lyase
Acin_2076	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Acin_2077	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Acin_2078	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Acin_2079	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Acin_2079	COG4499	WXG100 protein secretion system (Wss), protein YukC
Acin_2080	COG0166	Belongs to the GPI family
Acin_2083	COG2801	Transposase and inactivated derivatives
Acin_2088	COG0741	lytic transglycosylase activity
Acin_2089	COG0237	dephospho-CoA kinase activity
Acin_2090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Acin_2092	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Acin_2095	COG1115	amino acid carrier protein
Acin_2096	COG1757	Na H antiporter
Acin_2097	COG0798	PFAM Bile acid sodium symporter
Acin_2102	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Acin_2103	COG2022	thiamine diphosphate biosynthetic process
Acin_2107	COG0583	DNA-binding transcription factor activity
Acin_2113	COG0583	DNA-binding transcription factor activity
Acin_2114	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Acin_2116	COG3964	amidohydrolase
Acin_2122	COG0471	metal ion transport
Acin_2122	COG0490	domain, Protein
Acin_2125	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Acin_2127	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Acin_2130	COG4771	TonB-dependent receptor
Acin_2134	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Acin_2135	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Acin_2136	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Acin_2138	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Acin_2139	COG0085	RNA polymerase activity
Acin_2143	COG2801	Transposase and inactivated derivatives
Acin_2145	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Acin_2147	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Acin_2148	COG0697	spore germination
Acin_2149	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Acin_2150	COG0154	amidase activity
Acin_2151	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Acin_2152	COG0626	cystathionine gamma-synthase activity
Acin_2155	COG0752	glycyl-tRNA synthetase alpha subunit
Acin_2157	COG0531	amino acid
Acin_2158	COG0463	Glycosyl transferase, family 2
Acin_2161	COG1288	antiporter activity
Acin_2162	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acin_2163	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Acin_2164	COG0358	DNA primase activity
Acin_2166	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Acin_2167	COG0517	IMP dehydrogenase activity
Acin_2168	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Acin_2168	COG0574	Belongs to the PEP-utilizing enzyme family
Acin_2174	COG4139	cobalamin transport
Acin_2175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Acin_2181	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Acin_2184	COG1297	OPT oligopeptide transporter protein
Acin_2186	COG0159	tryptophan synthase activity
Acin_2187	COG0133	tryptophan synthase activity
Acin_2191	COG0512	Glutamine amidotransferase of anthranilate synthase
Acin_2197	COG2011	ABC-type metal ion transport system permease component
Acin_2198	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Acin_2203	COG0490	domain, Protein
Acin_2203	COG2985	domain, Protein
Acin_2205	COG1473	amidohydrolase
Acin_2206	COG3681	Belongs to the UPF0597 family
Acin_2208	COG0222	ribosome binding
Acin_2209	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Acin_2210	COG0081	regulation of translation
Acin_2211	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Acin_2212	COG0250	Participates in transcription elongation, termination and antitermination
Acin_2214	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Acin_2215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Acin_2220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Acin_2221	COG0426	domain, Protein
Acin_2222	COG1115	amino acid carrier protein
Acin_2223	COG4178	(ABC) transporter
Acin_2225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Acin_2227	COG0277	FAD linked oxidase domain protein
Acin_2228	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Acin_2229	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Acin_2230	COG0531	amino acid
Acin_2231	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Acin_2237	COG1335	isochorismatase
Acin_2239	COG2195	Cleaves the N-terminal amino acid of tripeptides
Acin_2240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Acin_2243	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Acin_2245	COG0248	Ppx GppA phosphatase
Acin_2249	COG1346	cytolysis
Acin_2252	COG1288	antiporter activity
Acin_2253	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Acin_2254	COG5599	Phosphatase
Acin_2255	COG1959	2 iron, 2 sulfur cluster binding
Acin_2257	COG0129	dihydroxy-acid dehydratase activity
Acin_2270	COG1683	Conserved Protein
Acin_2272	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Acin_2273	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Acin_2277	COG0583	DNA-binding transcription factor activity
Acin_2280	COG1473	amidohydrolase
Acin_2281	COG1288	antiporter activity
Acin_2283	COG0583	DNA-binding transcription factor activity
Acin_2286	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Acin_2288	COG1196	nuclear chromosome segregation
Acin_2291	COG2176	DNA-directed DNA polymerase activity
Acin_2294	COG2996	Protein conserved in bacteria
Acin_2295	COG0799	negative regulation of ribosome biogenesis
Acin_2296	COG1316	TRANSCRIPTIONal
Acin_2297	COG1713	HD superfamily hydrolase involved in NAD metabolism
Acin_2302	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Acin_2303	COG0012	GTP binding
Acin_2304	COG2239	Acts as a magnesium transporter
Acin_2306	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Acin_2306	COG1263	PTS System
Acin_2307	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Acin_2308	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Acin_2311	COG0203	ribosomal protein L17
Acin_2312	COG0202	RNA polymerase activity
Acin_2313	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Acin_2315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Acin_2317	COG0563	adenylate kinase activity
Acin_2318	COG0201	protein transport
Acin_2320	COG1841	ribosomal large subunit assembly
Acin_2321	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Acin_2322	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Acin_2323	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Acin_2324	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Acin_2325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Acin_2326	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Acin_2327	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Acin_2331	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Acin_2332	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Acin_2333	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Acin_2335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Acin_2336	COG0089	rRNA binding
Acin_2337	COG0088	Forms part of the polypeptide exit tunnel
Acin_2338	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Acin_2340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Acin_2342	COG0049	tRNA binding
Acin_2343	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Acin_2344	COG1358	cellular component organization or biogenesis
Acin_2350	COG0488	(ABC) transporter
Acin_2351	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Acin_2356	COG0542	response to heat
Acin_2362	COG1979	alcohol dehydrogenase
Acin_2363	COG2801	Transposase and inactivated derivatives
Acin_2364	COG1012	belongs to the aldehyde dehydrogenase family
Acin_2365	COG0640	Transcriptional regulator
Acin_2367	COG1114	Component of the transport system for branched-chain amino acids
Acin_2368	COG1028	Short-chain dehydrogenase reductase Sdr
Acin_2369	COG1278	Cold shock
Acin_2370	COG2827	Endonuclease containing a URI domain
Acin_2371	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Acin_2373	COG0492	ferredoxin-NADP+ reductase activity
Acin_2374	COG0739	heme binding
Acin_2374	COG0741	lytic transglycosylase activity
Acin_2374	COG1196	nuclear chromosome segregation
Acin_2375	COG0583	DNA-binding transcription factor activity
Acin_2380	COG2244	polysaccharide biosynthetic process
Acin_2382	COG1924	4 iron, 4 sulfur cluster binding
Acin_2383	COG0071	Belongs to the small heat shock protein (HSP20) family
Acin_2385	COG2801	Transposase and inactivated derivatives
Acin_2388	COG0519	Catalyzes the synthesis of GMP from XMP
Acin_2390	COG2801	Transposase and inactivated derivatives
Acin_2392	COG1115	amino acid carrier protein
Acin_2394	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Acin_2395	COG1322	Protein conserved in bacteria
Acin_2398	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Acin_2400	COG0534	Mate efflux family protein
Acin_2402	COG0114	fumarate hydratase activity
Acin_2404	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Acin_2405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Acin_2406	COG0066	3-isopropylmalate dehydratase activity
Acin_2410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Acin_2411	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Acin_2412	COG0305	Participates in initiation and elongation during chromosome replication
Acin_2414	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Acin_2418	COG2610	gluconate transmembrane transporter activity
Acin_2420	COG1473	amidohydrolase
Acin_2421	COG1160	GTP binding
Acin_2422	COG1160	GTP binding
Acin_2426	COG0252	asparaginase activity
Acin_2427	COG0156	8-amino-7-oxononanoate synthase activity
Acin_2433	COG0745	RESPONSE REGULATOR receiver
Acin_2435	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Acin_2436	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Acin_2437	COG0497	DNA recombination
Acin_2440	COG1475	DNA binding
Acin_2441	COG1192	Involved in chromosome partitioning
Acin_2442	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Acin_2443	COG1464	Belongs to the NlpA lipoprotein family
Acin_2447	COG0357	Ribosomal RNA small subunit methyltransferase G
Acin_2448	COG0445	tRNA wobble uridine modification
Acin_2449	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Acin_2450	COG1847	R3H domain protein
Acin_2452	COG0594	ribonuclease P activity
Acin_2453	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Acin_2454	COG2194	sulfuric ester hydrolase activity
Acin_2456	COG1115	amino acid carrier protein
Acin_2457	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Acin_2461	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Acin_2464	COG0823	Involved in the tonB-independent uptake of proteins
Acin_2464	COG1506	peptidase
Acin_2464	COG4946	Tricorn protease homolog