locus-tag	class	description
B6F84_00045	COG1337	RAMP superfamily
B6F84_00065	COG1203	CRISPR-associated helicase, Cas3
B6F84_00205	COG1111	helicase
B6F84_00205	COG1205	dead DEAH box helicase
B6F84_00215	COG1473	amidohydrolase
B6F84_00240	COG1725	Transcriptional regulator
B6F84_00255	COG0640	Transcriptional regulator
B6F84_00270	COG3842	ATPase activity
B6F84_00280	COG1175	transmembrane transport
B6F84_00325	COG1832	CoA-binding protein
B6F84_00365	COG0095	Lipoate-protein ligase
B6F84_00385	COG3511	phospholipase C
B6F84_00410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B6F84_00435	COG1215	transferase activity, transferring glycosyl groups
B6F84_00460	COG0297	glycogen (starch) synthase activity
B6F84_00520	COG0022	dehydrogenase e1 component
B6F84_00525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B6F84_00540	COG0183	Belongs to the thiolase family
B6F84_00545	COG1024	Enoyl-CoA hydratase
B6F84_00550	COG1024	Enoyl-CoA hydratase
B6F84_00570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6F84_00610	COG2124	cytochrome p450
B6F84_00615	COG2814	Major facilitator Superfamily
B6F84_00635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6F84_00685	COG1129	ABC transporter
B6F84_00690	COG1172	Belongs to the binding-protein-dependent transport system permease family
B6F84_00700	COG1028	Short-chain dehydrogenase reductase Sdr
B6F84_00720	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6F84_00745	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B6F84_00750	COG1960	acyl-CoA dehydrogenase activity
B6F84_00760	COG1960	acyl-CoA dehydrogenase activity
B6F84_00785	COG2151	metal-sulfur cluster biosynthetic enzyme
B6F84_00810	COG3350	monooxygenase activity
B6F84_00860	COG2050	protein possibly involved in aromatic compounds catabolism
B6F84_00875	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B6F84_00880	COG2086	electron transfer activity
B6F84_00885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_00890	COG1960	acyl-CoA dehydrogenase activity
B6F84_00915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_00935	COG2301	Belongs to the HpcH HpaI aldolase family
B6F84_00945	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6F84_00950	COG0674	pyruvate-flavodoxin oxidoreductase activity
B6F84_00955	COG1144	Oxidoreductase
B6F84_00980	COG0437	4 iron, 4 sulfur cluster binding
B6F84_00990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B6F84_01005	COG1177	transmembrane transport
B6F84_01030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_01035	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6F84_01065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B6F84_01135	COG0531	amino acid
B6F84_01145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6F84_01155	COG1846	Transcriptional regulator
B6F84_01190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6F84_01205	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
B6F84_01240	COG0243	molybdopterin cofactor binding
B6F84_01245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6F84_01255	COG2084	Dehydrogenase
B6F84_01275	COG1592	Rubrerythrin
B6F84_01280	COG0028	Belongs to the TPP enzyme family
B6F84_01285	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6F84_01300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6F84_01340	COG2079	MmgE PrpD family protein
B6F84_01345	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B6F84_01350	COG0516	GMP reductase activity
B6F84_01350	COG0517	IMP dehydrogenase activity
B6F84_01355	COG0372	Belongs to the citrate synthase family
B6F84_01375	COG0604	alcohol dehydrogenase
B6F84_01405	COG0525	valine-tRNA ligase activity
B6F84_01435	COG2814	Major facilitator Superfamily
B6F84_01445	COG1028	Short-chain dehydrogenase reductase Sdr
B6F84_01465	COG2271	Major facilitator Superfamily
B6F84_01495	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B6F84_01530	COG0114	fumarate hydratase activity
B6F84_01585	COG2860	membrane
B6F84_01595	COG1131	(ABC) transporter
B6F84_01610	COG0045	succinate-CoA ligase (ADP-forming) activity
B6F84_01610	COG1042	CoA-binding domain protein
B6F84_01610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B6F84_01620	COG0531	amino acid
B6F84_01625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_01660	COG1137	ATPase activity
B6F84_01675	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B6F84_01680	COG0066	3-isopropylmalate dehydratase activity
B6F84_01685	COG0778	Nitroreductase
B6F84_01715	COG0708	Exodeoxyribonuclease III
B6F84_01730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B6F84_01735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B6F84_01735	COG0352	thiamine-phosphate diphosphorylase activity
B6F84_01735	COG0351	phosphomethylpyrimidine kinase
B6F84_01750	COG0157	Belongs to the NadC ModD family
B6F84_01755	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
B6F84_01765	COG1515	deoxyribonuclease V activity
B6F84_01780	COG0450	alkyl hydroperoxide reductase
B6F84_01795	COG0372	Belongs to the citrate synthase family
B6F84_01825	COG4581	dead DEAH box helicase
B6F84_01830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6F84_01840	COG0439	Biotin carboxylase
B6F84_01850	COG1116	anion transmembrane transporter activity
B6F84_01860	COG0513	Belongs to the DEAD box helicase family
B6F84_01890	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6F84_01900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6F84_01910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_01945	COG0477	Major facilitator Superfamily
B6F84_01960	COG0671	phosphoesterase, PA-phosphatase related
B6F84_01975	COG0243	molybdopterin cofactor binding
B6F84_02000	COG1215	transferase activity, transferring glycosyl groups
B6F84_02005	COG1215	transferase activity, transferring glycosyl groups
B6F84_02020	COG1201	RNA secondary structure unwinding
B6F84_02065	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B6F84_02070	COG0123	including yeast histone deacetylase and acetoin utilization protein
B6F84_02075	COG0517	IMP dehydrogenase activity
B6F84_02075	COG0516	GMP reductase activity
B6F84_02080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6F84_02105	COG1192	Involved in chromosome partitioning
B6F84_02145	COG1131	(ABC) transporter
B6F84_02155	COG1024	Enoyl-CoA hydratase
B6F84_02160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6F84_02180	COG0438	transferase activity, transferring glycosyl groups
B6F84_02185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6F84_02225	COG1331	Highly conserved protein containing a thioredoxin domain
B6F84_02235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B6F84_02290	COG0330	HflC and HflK could
B6F84_02315	COG2154	pterin-4-alpha-carbinolamine dehydratase
B6F84_02330	COG0538	isocitrate dehydrogenase activity
B6F84_02370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B6F84_02385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B6F84_02385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6F84_02390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B6F84_02420	COG0537	adenosine 5'-monophosphoramidase activity
B6F84_02435	COG0154	amidase activity
B6F84_02440	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
B6F84_02445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B6F84_02450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B6F84_02450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B6F84_02470	COG0497	DNA recombination
B6F84_02495	COG0517	IMP dehydrogenase activity
B6F84_02495	COG0516	GMP reductase activity
B6F84_02505	COG0735	belongs to the Fur family
B6F84_02510	COG1957	nucleoside hydrolase
B6F84_02610	COG0492	ferredoxin-NADP+ reductase activity
B6F84_02620	COG2814	Major facilitator Superfamily
B6F84_02625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B6F84_02645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B6F84_02655	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B6F84_02670	COG0561	phosphatase activity
B6F84_02720	COG0516	GMP reductase activity
B6F84_02725	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B6F84_02730	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6F84_02750	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B6F84_02760	COG0297	glycogen (starch) synthase activity
B6F84_02780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6F84_02790	COG0469	pyruvate kinase activity
B6F84_02810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6F84_02815	COG0546	phosphoglycolate phosphatase activity
B6F84_02825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B6F84_02895	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B6F84_02900	COG1051	belongs to the nudix hydrolase family
B6F84_02905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_02910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6F84_02925	COG0430	RNA-3'-phosphate cyclase activity
B6F84_02990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6F84_03030	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B6F84_03045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_03055	COG0492	ferredoxin-NADP+ reductase activity
B6F84_03100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6F84_03105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B6F84_03130	COG4555	ABC transporter
B6F84_03140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B6F84_03170	COG0351	phosphomethylpyrimidine kinase
B6F84_03185	COG1215	transferase activity, transferring glycosyl groups
B6F84_03190	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
B6F84_03225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6F84_03230	COG0183	Belongs to the thiolase family
B6F84_03270	COG0626	cystathionine gamma-synthase activity
B6F84_03275	COG0083	homoserine kinase activity
B6F84_03295	COG0714	Associated with various cellular activities
B6F84_03300	COG2304	oxidoreductase activity
B6F84_03325	COG0647	UMP catabolic process
B6F84_03350	COG1446	asparaginase
B6F84_03365	COG1522	sequence-specific DNA binding
B6F84_03370	COG0569	domain protein
B6F84_03370	COG0189	ligase activity
B6F84_03375	COG0142	geranyltranstransferase activity
B6F84_03385	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B6F84_03390	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B6F84_03420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B6F84_03455	COG4555	ABC transporter
B6F84_03480	COG2409	Drug exporters of the RND superfamily
B6F84_03495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B6F84_03510	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B6F84_03555	COG2308	Evidence 4 Homologs of previously reported genes of
B6F84_03560	COG3387	PFAM Glycoside hydrolase 15-related
B6F84_03570	COG2723	6-phospho-beta-galactosidase activity
B6F84_03585	COG0477	Major facilitator Superfamily
B6F84_03590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6F84_03620	COG0531	amino acid
B6F84_03650	COG0477	Major facilitator Superfamily
B6F84_03680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B6F84_03685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6F84_03690	COG1121	(ABC) transporter
B6F84_03700	COG0519	Catalyzes the synthesis of GMP from XMP
B6F84_03710	COG2814	Major facilitator Superfamily
B6F84_03720	COG0673	inositol 2-dehydrogenase activity
B6F84_03730	COG0531	amino acid
B6F84_03760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B6F84_03835	COG0675	Transposase, IS605 OrfB family
B6F84_03840	COG0589	response to stress
B6F84_03870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6F84_03885	COG0674	pyruvate-flavodoxin oxidoreductase activity
B6F84_03885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B6F84_03890	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6F84_03900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6F84_03910	COG1733	regulation of RNA biosynthetic process
B6F84_03935	COG1129	ABC transporter
B6F84_03945	COG0531	amino acid
B6F84_03955	COG3383	formate dehydrogenase (NAD+) activity
B6F84_03965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B6F84_03995	COG1012	belongs to the aldehyde dehydrogenase family
B6F84_04075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
B6F84_04095	COG0309	Hydrogenase expression formation protein (HypE)
B6F84_04105	COG0409	Hydrogenase expression formation protein
B6F84_04120	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
B6F84_04165	COG2226	methyltransferase
B6F84_04215	COG1215	transferase activity, transferring glycosyl groups
B6F84_04255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B6F84_04260	COG2226	methyltransferase
B6F84_04305	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
B6F84_04385	COG0298	carbon dioxide binding
B6F84_04390	COG0409	Hydrogenase expression formation protein
B6F84_04395	COG0235	Class ii aldolase
B6F84_04410	COG1733	regulation of RNA biosynthetic process
B6F84_04445	COG0298	carbon dioxide binding
B6F84_04530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B6F84_04530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6F84_04535	COG0167	dihydroorotate dehydrogenase activity
B6F84_04555	COG1953	Uracil, thiamine, allantoin
B6F84_04580	COG2235	arginine
B6F84_04590	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
B6F84_04595	COG0402	S-adenosylhomocysteine deaminase activity
B6F84_04600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6F84_04605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6F84_04610	COG0477	Major facilitator Superfamily
B6F84_04620	COG4638	Rieske (2fe-2S)
B6F84_04630	COG0174	glutamine synthetase
B6F84_04660	COG0531	amino acid
B6F84_04665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6F84_04670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6F84_04695	COG0402	S-adenosylhomocysteine deaminase activity
B6F84_04700	COG0277	FAD linked oxidase domain protein
B6F84_04705	COG0277	FAD linked oxidase domain protein
B6F84_04715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6F84_04720	COG0243	molybdopterin cofactor binding
B6F84_04725	COG1017	nitric oxide dioxygenase activity
B6F84_04750	COG0402	S-adenosylhomocysteine deaminase activity
B6F84_04795	COG0832	Belongs to the urease beta subunit family
B6F84_04795	COG0831	urea catabolic process
B6F84_04815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B6F84_04830	COG1953	Uracil, thiamine, allantoin
B6F84_04835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B6F84_04840	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B6F84_04890	COG4608	Belongs to the ABC transporter superfamily
B6F84_04895	COG0444	Belongs to the ABC transporter superfamily
B6F84_04900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6F84_04905	COG0601	transmembrane transport
B6F84_04915	COG4948	Mandelate Racemase Muconate Lactonizing
B6F84_04920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6F84_04950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_04965	COG1132	(ABC) transporter
B6F84_04970	COG4948	Mandelate Racemase Muconate Lactonizing
B6F84_04975	COG1012	belongs to the aldehyde dehydrogenase family
B6F84_04980	COG3386	PFAM SMP-30 Gluconolaconase
B6F84_04985	COG1028	Short-chain dehydrogenase reductase Sdr
B6F84_04990	COG1802	Transcriptional regulator
B6F84_05000	COG2721	sulfolactate sulfo-lyase activity
B6F84_05005	COG2721	sulfolactate sulfo-lyase activity
B6F84_05010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6F84_05015	COG2814	Major facilitator Superfamily
B6F84_05025	COG4608	Belongs to the ABC transporter superfamily
B6F84_05035	COG0601	transmembrane transport
B6F84_05050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6F84_05095	COG2814	Major facilitator Superfamily
B6F84_05105	COG2814	Major facilitator Superfamily
B6F84_05125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6F84_05150	COG0444	Belongs to the ABC transporter superfamily
B6F84_05165	COG2153	protein acetylation
B6F84_05170	COG0281	malic enzyme
B6F84_05175	COG0531	amino acid
B6F84_05185	COG0656	L-ascorbic acid biosynthetic process
B6F84_05195	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B6F84_05195	COG3608	succinylglutamate desuccinylase aspartoacylase
B6F84_05205	COG1454	alcohol dehydrogenase
B6F84_05210	COG0675	Transposase, IS605 OrfB family
B6F84_05275	COG0574	Belongs to the PEP-utilizing enzyme family
B6F84_05275	COG3848	Pyruvate phosphate dikinase
B6F84_05285	COG0450	alkyl hydroperoxide reductase
B6F84_05295	COG0318	PFAM AMP-dependent synthetase and ligase
B6F84_05300	COG1028	Short-chain dehydrogenase reductase Sdr
B6F84_05330	COG2046	Belongs to the sulfate adenylyltransferase family
B6F84_05340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6F84_05345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6F84_05350	COG1960	acyl-CoA dehydrogenase activity
B6F84_05355	COG0318	PFAM AMP-dependent synthetase and ligase
B6F84_05360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B6F84_05370	COG0667	Aldo Keto reductase
B6F84_05375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B6F84_05385	COG2368	4-hydroxyphenylacetate
B6F84_05395	COG0477	Major facilitator Superfamily
B6F84_05410	COG1051	belongs to the nudix hydrolase family
B6F84_05410	COG1056	cytidyltransferase-related domain
B6F84_05430	COG0318	PFAM AMP-dependent synthetase and ligase
B6F84_05440	COG1024	Enoyl-CoA hydratase
B6F84_05450	COG0183	Belongs to the thiolase family
B6F84_05455	COG1960	acyl-CoA dehydrogenase activity
B6F84_05460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B6F84_05465	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B6F84_05470	COG1012	belongs to the aldehyde dehydrogenase family
B6F84_05485	COG0028	Belongs to the TPP enzyme family
B6F84_05490	COG1028	Short-chain dehydrogenase reductase Sdr
B6F84_05495	COG0318	PFAM AMP-dependent synthetase and ligase
B6F84_05530	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B6F84_05535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_05540	COG0516	GMP reductase activity
B6F84_05540	COG0517	IMP dehydrogenase activity
B6F84_05560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_05565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6F84_05630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6F84_05640	COG0412	Dienelactone hydrolase
B6F84_05650	COG1312	Catalyzes the dehydration of D-mannonate
B6F84_05655	COG1139	Iron-sulfur cluster binding protein
B6F84_05665	COG2271	Major facilitator Superfamily
B6F84_05680	COG4948	Mandelate Racemase Muconate Lactonizing
B6F84_05685	COG2814	Major facilitator Superfamily
B6F84_05690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B6F84_05700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6F84_05720	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
B6F84_05740	COG1233	COG1233 Phytoene dehydrogenase and related
B6F84_05750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6F84_05755	COG0731	radical SAM domain protein
B6F84_05755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6F84_05765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B6F84_05770	COG0516	GMP reductase activity
B6F84_05770	COG0517	IMP dehydrogenase activity
B6F84_05785	COG1505	serine-type exopeptidase activity
B6F84_05805	COG2814	Major facilitator Superfamily
B6F84_05810	COG0561	phosphatase activity
B6F84_05820	COG0277	FAD linked oxidase domain protein
B6F84_05825	COG2814	Major facilitator Superfamily
B6F84_05850	COG3387	PFAM Glycoside hydrolase 15-related
B6F84_05905	COG0477	Major facilitator Superfamily
B6F84_05910	COG1953	Uracil, thiamine, allantoin
B6F84_05915	COG1741	Belongs to the pirin family
B6F84_05935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B6F84_05950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6F84_05955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6F84_05965	COG2062	phosphohistidine phosphatase, SixA
B6F84_05970	COG0028	Belongs to the TPP enzyme family
B6F84_05995	COG0477	Major facilitator Superfamily
B6F84_06000	COG1011	Hydrolase
B6F84_06010	COG0174	glutamine synthetase
B6F84_06020	COG2271	Major facilitator Superfamily
B6F84_06045	COG0109	protoheme IX farnesyltransferase activity
B6F84_06080	COG1960	acyl-CoA dehydrogenase activity
B6F84_06085	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B6F84_06095	COG1607	acyl-coa hydrolase
B6F84_06115	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6F84_06125	COG2222	sugar isomerase
B6F84_06130	COG0215	cysteine-tRNA ligase activity
B6F84_06145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B6F84_06155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6F84_06160	COG1028	Short-chain dehydrogenase reductase Sdr
B6F84_06165	COG1573	uracil-dna glycosylase
B6F84_06195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6F84_06215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6F84_06220	COG1703	isobutyryl-CoA mutase activity
B6F84_06230	COG0596	Alpha beta hydrolase
B6F84_06250	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B6F84_06255	COG1881	PFAM PEBP family protein
B6F84_06260	COG2255	four-way junction helicase activity
B6F84_06265	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B6F84_06265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B6F84_06270	COG0315	cyclic pyranopterin monophosphate synthase activity
B6F84_06325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6F84_06355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B6F84_06360	COG1444	tRNA N-acetyltransferase activity
B6F84_06380	COG0589	response to stress
B6F84_06385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6F84_06390	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B6F84_06390	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B6F84_06395	COG0009	L-threonylcarbamoyladenylate synthase
B6F84_06400	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6F84_06405	COG2379	hydroxypyruvate reductase
B6F84_06415	COG1321	iron dependent repressor
B6F84_06445	COG1763	Mo-molybdopterin cofactor biosynthetic process
B6F84_06450	COG0303	'Molybdopterin
B6F84_06455	COG0746	molybdenum cofactor guanylyltransferase activity
B6F84_06470	COG0402	S-adenosylhomocysteine deaminase activity
B6F84_06500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6F84_06520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6F84_06545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B6F84_06555	COG1215	transferase activity, transferring glycosyl groups
B6F84_06560	COG1201	RNA secondary structure unwinding
B6F84_06570	COG4109	DRTGG domain
B6F84_06595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6F84_06600	COG1546	Belongs to the CinA family
B6F84_06600	COG1058	Belongs to the CinA family
B6F84_06610	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B6F84_06615	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B6F84_06620	COG0024	Methionine aminopeptidase
B6F84_06650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B6F84_06655	COG1358	cellular component organization or biogenesis
B6F84_06670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6F84_06675	COG0142	geranyltranstransferase activity
B6F84_06680	COG1304	FMN binding
B6F84_06695	COG1355	regulation of microtubule-based process
B6F84_06700	COG0052	Belongs to the universal ribosomal protein uS2 family
B6F84_06710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B6F84_06715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B6F84_06730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B6F84_06735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B6F84_06740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B6F84_06750	COG0432	Pfam Uncharacterised protein family UPF0047
B6F84_06760	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B6F84_06770	COG0417	DNA replication proofreading
B6F84_06805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B6F84_06825	COG3276	selenocysteine insertion sequence binding
B6F84_06840	COG0023	Translation Initiation Factor
B6F84_06850	COG0010	Belongs to the arginase family
B6F84_06855	COG0423	glycine-tRNA ligase activity
B6F84_06885	COG0163	prenyltransferase activity
B6F84_06895	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
B6F84_06910	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B6F84_06915	COG2815	serine threonine protein kinase
B6F84_06915	COG0515	serine threonine protein kinase
B6F84_06920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B6F84_06925	COG0667	Aldo Keto reductase
B6F84_06970	COG1110	DNA topoisomerase II activity
B6F84_06975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_06980	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
B6F84_06995	COG0557	exoribonuclease II activity
B6F84_07030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B6F84_07045	COG1797	cobyrinic acid a,c-diamide synthase activity
B6F84_07060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6F84_07060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6F84_07070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B6F84_07100	COG1201	RNA secondary structure unwinding
B6F84_07115	COG2813	Specifically methylates the guanine in position
B6F84_07120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6F84_07125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6F84_07140	COG0051	transcription antitermination factor activity, RNA binding
B6F84_07145	COG2895	sulfate adenylyltransferase (ATP) activity
B6F84_07150	COG0049	tRNA binding
B6F84_07175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B6F84_07180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B6F84_07185	COG0085	RNA polymerase activity
B6F84_07195	COG0281	malic enzyme
B6F84_07200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B6F84_07220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B6F84_07230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6F84_07245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B6F84_07250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B6F84_07265	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B6F84_07280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B6F84_07285	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B6F84_07295	COG0077	Prephenate dehydratase
B6F84_07295	COG1605	Chorismate mutase
B6F84_07300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B6F84_07335	COG1056	cytidyltransferase-related domain
B6F84_07335	COG1051	belongs to the nudix hydrolase family
B6F84_07340	COG1607	acyl-coa hydrolase
B6F84_07390	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B6F84_07405	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B6F84_07415	COG1121	(ABC) transporter
B6F84_07420	COG1980	fructose-bisphosphate aldolase activity
B6F84_07460	COG0124	histidyl-tRNA synthetase
B6F84_07495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_07505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B6F84_07545	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B6F84_07590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6F84_07595	COG2264	protein methyltransferase activity
B6F84_07600	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
B6F84_07610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6F84_07615	COG0012	GTP binding
B6F84_07655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B6F84_07660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B6F84_07690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B6F84_07710	COG0473	3-isopropylmalate dehydrogenase activity
B6F84_07715	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B6F84_07740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B6F84_07745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B6F84_07750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B6F84_07755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B6F84_07760	COG0255	Belongs to the universal ribosomal protein uL29 family
B6F84_07775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B6F84_07780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B6F84_07790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B6F84_07800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B6F84_07805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B6F84_07825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B6F84_07835	COG0200	Binds to the 23S rRNA
B6F84_07935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B6F84_07955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6F84_07975	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B6F84_07980	COG0504	CTP synthase activity
B6F84_07995	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
B6F84_08025	COG2078	PFAM AMMECR1 domain protein
B6F84_08040	COG0717	Belongs to the dCTP deaminase family
B6F84_08045	COG1793	dna ligase
B6F84_08055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6F84_08080	COG0181	hydroxymethylbilane synthase activity
B6F84_08085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B6F84_08090	COG0113	porphobilinogen synthase activity
B6F84_08095	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B6F84_08105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6F84_08105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6F84_08115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_08140	COG0017	Asparaginyl-tRNA synthetase
B6F84_08165	COG0028	Belongs to the TPP enzyme family
B6F84_08185	COG1047	Peptidyl-prolyl cis-trans
B6F84_08190	COG0371	Dehydrogenase
B6F84_08195	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B6F84_08250	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B6F84_08265	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B6F84_08270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B6F84_08285	COG0189	ligase activity
B6F84_08290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6F84_08295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6F84_08300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6F84_08320	COG0517	IMP dehydrogenase activity
B6F84_08320	COG0516	GMP reductase activity
B6F84_08365	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B6F84_08370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B6F84_08400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6F84_08405	COG0515	serine threonine protein kinase
B6F84_08410	COG0251	oxidation-reduction process
B6F84_08430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B6F84_08430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B6F84_08435	COG2239	Acts as a magnesium transporter
B6F84_08450	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B6F84_08455	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B6F84_08500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B6F84_08575	COG1720	tRNA m6t6A37 methyltransferase activity
B6F84_08595	COG0037	tRNA processing
B6F84_08610	COG0513	Belongs to the DEAD box helicase family
B6F84_08695	COG0489	protein tyrosine kinase activity
B6F84_08735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6F84_08760	COG4974	Belongs to the 'phage' integrase family
B6F84_08855	COG0438	transferase activity, transferring glycosyl groups
B6F84_08885	COG0275	rRNA processing
B6F84_08945	COG0275	rRNA processing
B6F84_09095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_09150	COG0438	transferase activity, transferring glycosyl groups
B6F84_09170	COG3830	Belongs to the UPF0237 family
B6F84_09210	COG1063	alcohol dehydrogenase
B6F84_09220	COG1131	(ABC) transporter
B6F84_09230	COG1914	H( )-stimulated, divalent metal cation uptake system
B6F84_09250	COG0477	Major facilitator Superfamily
B6F84_09260	COG0501	Belongs to the peptidase M48B family
B6F84_09275	COG2814	Major facilitator Superfamily
B6F84_09280	COG1968	undecaprenyl-diphosphatase activity
B6F84_09325	COG1215	transferase activity, transferring glycosyl groups
B6F84_09335	COG0352	thiamine-phosphate diphosphorylase activity
B6F84_09335	COG0351	phosphomethylpyrimidine kinase
B6F84_09340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6F84_09345	COG1234	tRNA 3'-trailer cleavage
B6F84_09370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6F84_09385	COG0463	Glycosyl transferase, family 2
B6F84_09400	COG0501	Belongs to the peptidase M48B family
B6F84_09410	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B6F84_09425	COG0519	Catalyzes the synthesis of GMP from XMP
B6F84_09425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B6F84_09430	COG0501	Belongs to the peptidase M48B family
B6F84_09450	COG1830	Aldolase
B6F84_09470	COG0405	Gamma-glutamyltransferase
B6F84_09485	COG1444	tRNA N-acetyltransferase activity
B6F84_09505	COG0589	response to stress
B6F84_09520	COG0864	Transcriptional regulator
B6F84_09535	COG0109	protoheme IX farnesyltransferase activity
B6F84_09545	COG1024	Enoyl-CoA hydratase
B6F84_09585	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6F84_09595	COG0189	ligase activity
B6F84_09615	COG0137	argininosuccinate synthase activity
B6F84_09630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B6F84_09635	COG0151	Belongs to the GarS family
B6F84_09640	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B6F84_09645	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B6F84_09650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6F84_09655	COG0047	phosphoribosylformylglycinamidine synthase activity
B6F84_09665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B6F84_09675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6F84_09680	COG0602	queuosine metabolic process
B6F84_09695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6F84_09725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B6F84_09730	COG0540	Belongs to the ATCase OTCase family
B6F84_09735	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
B6F84_09750	COG0167	dihydroorotate dehydrogenase activity
B6F84_09770	COG1522	sequence-specific DNA binding
B6F84_09785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6F84_09790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B6F84_09795	COG2151	metal-sulfur cluster biosynthetic enzyme
B6F84_09805	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B6F84_09815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B6F84_09820	COG0107	imidazoleglycerol-phosphate synthase activity
B6F84_09825	COG0131	Imidazoleglycerol-phosphate dehydratase
B6F84_09830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B6F84_09835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B6F84_09840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6F84_09850	COG0495	leucyl-tRNA aminoacylation
B6F84_09855	COG2096	Adenosyltransferase
B6F84_09860	COG0037	tRNA processing
B6F84_09870	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B6F84_09885	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B6F84_09895	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B6F84_09900	COG0546	phosphoglycolate phosphatase activity
B6F84_09905	COG0028	Belongs to the TPP enzyme family
B6F84_09930	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B6F84_09935	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B6F84_09945	COG0442	prolyl-tRNA aminoacylation
B6F84_09955	COG1394	ATPase activity, coupled to movement of substances
B6F84_09985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6F84_09985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6F84_10020	COG0417	DNA replication proofreading
B6F84_10035	COG1260	myo-inositol-1-phosphate synthase
B6F84_10040	COG1007	ATP synthesis coupled electron transport
B6F84_10045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6F84_10050	COG0713	ATP synthesis coupled electron transport
B6F84_10060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6F84_10065	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B6F84_10070	COG0649	NAD binding
B6F84_10075	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6F84_10085	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B6F84_10105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B6F84_10140	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B6F84_10155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6F84_10165	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B6F84_10170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B6F84_10175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B6F84_10180	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B6F84_10185	COG1605	Chorismate mutase
B6F84_10185	COG0077	Prephenate dehydratase
B6F84_10190	COG3958	Transketolase
B6F84_10195	COG3959	Transketolase, thiamine diphosphate binding domain
B6F84_10200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B6F84_10260	COG0069	glutamate synthase activity
B6F84_10265	COG0067	glutamate synthase
B6F84_10475	COG1185	polyribonucleotide nucleotidyltransferase activity
B6F84_10510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6F84_10520	COG1234	tRNA 3'-trailer cleavage
B6F84_10535	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B6F84_10715	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B6F84_10725	COG4221	oxidoreductase activity
B6F84_10730	COG0084	hydrolase, TatD family'
B6F84_10755	COG4974	Belongs to the 'phage' integrase family
B6F84_10760	COG0535	radical SAM domain protein
B6F84_10770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6F84_10770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B6F84_10780	COG0318	PFAM AMP-dependent synthetase and ligase
B6F84_10785	COG3118	belongs to the thioredoxin family
B6F84_10795	COG0174	glutamine synthetase
B6F84_10805	COG0302	gtp cyclohydrolase
B6F84_10810	COG0006	proline dipeptidase activity
B6F84_10815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B6F84_10830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B6F84_10895	COG0552	protein localization to endoplasmic reticulum
B6F84_10910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B6F84_10915	COG0081	regulation of translation
B6F84_10930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6F84_10950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6F84_10970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6F84_10975	COG0589	response to stress
B6F84_10985	COG0126	phosphoglycerate kinase activity
B6F84_11045	COG0719	Fe-S assembly protein
B6F84_11050	COG0396	ATPase activity
B6F84_11070	COG0509	glycine decarboxylation via glycine cleavage system
B6F84_11075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6F84_11080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B6F84_11085	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B6F84_11105	COG0148	phosphopyruvate hydratase activity
B6F84_11125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_11130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6F84_11145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B6F84_11185	COG0525	valine-tRNA ligase activity
B6F84_11190	COG0436	Aminotransferase
B6F84_11195	COG0134	indole-3-glycerol-phosphate synthase activity
B6F84_11200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B6F84_11200	COG0512	Glutamine amidotransferase of anthranilate synthase
B6F84_11205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B6F84_11210	COG0135	phosphoribosylanthranilate isomerase activity
B6F84_11215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B6F84_11220	COG0159	tryptophan synthase activity
B6F84_11225	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
B6F84_11230	COG1254	Belongs to the acylphosphatase family
B6F84_11235	COG1260	myo-inositol-1-phosphate synthase
B6F84_11245	COG0574	Belongs to the PEP-utilizing enzyme family
B6F84_11245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6F84_11270	COG0460	homoserine dehydrogenase
B6F84_11270	COG0527	aspartate kinase activity
B6F84_11275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B6F84_11280	COG0613	PHP domain protein
B6F84_11290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B6F84_11320	COG0459	protein refolding
B6F84_11380	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6F84_11385	COG0252	asparaginase activity
B6F84_11415	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
B6F84_11465	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B6F84_11465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B6F84_11480	COG0154	amidase activity
B6F84_11485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6F84_11490	COG1324	tolerance protein
B6F84_11500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B6F84_11525	COG1110	DNA topoisomerase II activity
B6F84_11535	COG0514	ATP-dependent DNA helicase (RecQ)
B6F84_11565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B6F84_11570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B6F84_11580	COG2084	Dehydrogenase
B6F84_11585	COG0438	transferase activity, transferring glycosyl groups
B6F84_11600	COG0528	UMP kinase activity
B6F84_11610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6F84_11620	COG0535	radical SAM domain protein
B6F84_11660	COG1131	(ABC) transporter
B6F84_11740	COG1215	transferase activity, transferring glycosyl groups
B6F84_11745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6F84_11750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6F84_11790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B6F84_11795	COG0004	ammonium transporteR
B6F84_11825	COG2409	Drug exporters of the RND superfamily
B6F84_11840	COG0589	response to stress
B6F84_11860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6F84_11865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6F84_11870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B6F84_11905	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B6F84_11940	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B6F84_11980	COG2149	membrane
B6F84_11990	COG1522	sequence-specific DNA binding
B6F84_11995	COG3386	PFAM SMP-30 Gluconolaconase
B6F84_12050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B6F84_12060	COG2814	Major facilitator Superfamily
B6F84_12065	COG0477	Major facilitator Superfamily
B6F84_12120	COG1335	isochorismatase
B6F84_12130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B6F84_12200	COG1573	uracil-dna glycosylase
B6F84_12210	COG4946	Tricorn protease homolog
B6F84_12210	COG0823	Involved in the tonB-independent uptake of proteins
B6F84_12210	COG1506	peptidase
B6F84_12240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_12265	COG1012	belongs to the aldehyde dehydrogenase family
B6F84_12270	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
B6F84_12280	COG4946	Tricorn protease homolog
B6F84_12280	COG1506	peptidase
B6F84_12280	COG0823	Involved in the tonB-independent uptake of proteins
B6F84_12290	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6F84_12300	COG1122	ATPase activity
B6F84_12310	COG3511	phospholipase C
B6F84_12340	COG0651	ATP synthesis coupled electron transport
B6F84_12345	COG0649	NAD binding
B6F84_12360	COG0650	Formate hydrogenlyase subunit 4
B6F84_12395	COG0730	response to heat
B6F84_12400	COG0813	purine-nucleoside phosphorylase activity
B6F84_12480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B6F84_12500	COG0667	Aldo Keto reductase
B6F84_12545	COG0123	including yeast histone deacetylase and acetoin utilization protein
B6F84_12560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6F84_12570	COG2210	Belongs to the sulfur carrier protein TusA family
B6F84_12575	COG0425	Belongs to the sulfur carrier protein TusA family
B6F84_12590	COG0492	ferredoxin-NADP+ reductase activity
B6F84_12605	COG2048	Heterodisulfide reductase, subunit B
B6F84_12615	COG0509	glycine decarboxylation via glycine cleavage system
B6F84_12625	COG2814	Major facilitator Superfamily
B6F84_12630	COG0477	Major facilitator Superfamily
B6F84_12635	COG0095	Lipoate-protein ligase
B6F84_12640	COG0095	Lipoate-protein ligase
B6F84_12650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B6F84_12660	COG0450	alkyl hydroperoxide reductase
B6F84_12680	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B6F84_12685	COG0509	glycine decarboxylation via glycine cleavage system
B6F84_12690	COG0095	Lipoate-protein ligase
B6F84_12735	COG0644	oxidoreductase
B6F84_12745	COG1131	(ABC) transporter
B6F84_12805	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6F84_12815	COG0475	glutathione-regulated potassium exporter activity
B6F84_12845	COG2814	Major facilitator Superfamily
B6F84_12905	COG2814	Major facilitator Superfamily
B6F84_12930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B6F84_12975	COG1401	restriction endodeoxyribonuclease activity
B6F84_12985	COG0456	acetyltransferase
B6F84_13010	COG2814	Major facilitator Superfamily
B6F84_13030	COG1131	(ABC) transporter
B6F84_13060	COG2217	Heavy metal translocating P-type atpase
B6F84_13065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B6F84_13065	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B6F84_13105	COG0425	Belongs to the sulfur carrier protein TusA family
B6F84_13115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B6F84_13115	COG0425	Belongs to the sulfur carrier protein TusA family
B6F84_13160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B6F84_13170	COG0805	protein transport
B6F84_13200	COG0277	FAD linked oxidase domain protein
B6F84_13220	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6F84_13225	COG0674	pyruvate-flavodoxin oxidoreductase activity
B6F84_13245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6F84_13255	COG0535	radical SAM domain protein
B6F84_13320	COG1271	oxidase subunit
B6F84_13360	COG1373	ATPase (AAA superfamily
B6F84_13390	COG0531	amino acid
B6F84_13460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6F84_13555	COG0145	ligase activity
B6F84_13650	COG1091	dTDP-4-dehydrorhamnose reductase activity
B6F84_13695	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B6F84_13700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA