locus-tag	class	description
HS5_00060	COG0426	domain, Protein
HS5_00060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HS5_00140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HS5_00150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HS5_00170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HS5_00180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HS5_00230	COG0004	ammonium transporteR
HS5_00290	COG0438	transferase activity, transferring glycosyl groups
HS5_00310	COG0589	response to stress
HS5_00350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HS5_00360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HS5_00370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HS5_00400	COG0045	succinate-CoA ligase (ADP-forming) activity
HS5_00440	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HS5_00450	COG1078	dGTPase activity
HS5_00520	COG1832	CoA-binding protein
HS5_00530	COG0179	Fumarylacetoacetate (FAA) hydrolase
HS5_00590	COG3386	PFAM SMP-30 Gluconolaconase
HS5_00610	COG1695	Transcriptional regulator
HS5_00700	COG2814	Major facilitator Superfamily
HS5_00710	COG1335	isochorismatase
HS5_00890	COG3511	phospholipase C
HS5_00910	COG1122	ATPase activity
HS5_00990	COG0813	purine-nucleoside phosphorylase activity
HS5_01000	COG0730	response to heat
HS5_01010	COG0531	amino acid
HS5_01060	COG0535	radical SAM domain protein
HS5_01070	COG0535	radical SAM domain protein
HS5_01110	COG0644	oxidoreductase
HS5_01130	COG2086	electron transfer activity
HS5_01140	COG1960	acyl-CoA dehydrogenase activity
HS5_01150	COG0243	molybdopterin cofactor binding
HS5_01200	COG1175	transmembrane transport
HS5_01210	COG1177	transmembrane transport
HS5_01240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HS5_01330	COG2210	Belongs to the sulfur carrier protein TusA family
HS5_01340	COG0425	Belongs to the sulfur carrier protein TusA family
HS5_01370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS5_01400	COG2048	Heterodisulfide reductase, subunit B
HS5_01450	COG0509	glycine decarboxylation via glycine cleavage system
HS5_01460	COG0095	Lipoate-protein ligase
HS5_01490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HS5_01530	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HS5_01630	COG0437	4 iron, 4 sulfur cluster binding
HS5_01640	COG0243	molybdopterin cofactor binding
HS5_01710	COG0805	protein transport
HS5_01730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HS5_01800	COG2329	Antibiotic biosynthesis monooxygenase
HS5_01840	COG0477	Major facilitator Superfamily
HS5_01960	COG0589	response to stress
HS5_01970	COG2814	Major facilitator Superfamily
HS5_01980	COG1914	H( )-stimulated, divalent metal cation uptake system
HS5_02200	COG0028	Belongs to the TPP enzyme family
HS5_02230	COG2814	Major facilitator Superfamily
HS5_02240	COG1846	Transcriptional regulator
HS5_02300	COG1373	ATPase (AAA superfamily
HS5_02370	COG2217	Heavy metal translocating P-type atpase
HS5_02790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HS5_02820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HS5_02830	COG0463	Glycosyl transferase, family 2
HS5_02830	COG1216	Glycosyl transferase, family 2
HS5_02910	COG1215	transferase activity, transferring glycosyl groups
HS5_03060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HS5_03450	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HS5_03520	COG1312	Catalyzes the dehydration of D-mannonate
HS5_03540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HS5_03550	COG2264	protein methyltransferase activity
HS5_03580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HS5_03750	COG1113	amino acid transport
HS5_04110	COG0477	Major facilitator Superfamily
HS5_04130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_04160	COG2226	methyltransferase
HS5_04300	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HS5_04320	COG3383	formate dehydrogenase (NAD+) activity
HS5_04330	COG0515	serine threonine protein kinase
HS5_04330	COG2815	serine threonine protein kinase
HS5_04440	COG2815	serine threonine protein kinase
HS5_04440	COG0515	serine threonine protein kinase
HS5_04640	COG3391	amine dehydrogenase activity
HS5_04750	COG2151	metal-sulfur cluster biosynthetic enzyme
HS5_04760	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HS5_04910	COG1013	pyruvate-flavodoxin oxidoreductase activity
HS5_04920	COG0674	pyruvate-flavodoxin oxidoreductase activity
HS5_04930	COG1144	Oxidoreductase
HS5_04940	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HS5_04950	COG0437	4 iron, 4 sulfur cluster binding
HS5_04980	COG1960	acyl-CoA dehydrogenase activity
HS5_04990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HS5_05000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HS5_05020	COG1960	acyl-CoA dehydrogenase activity
HS5_05040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HS5_05110	COG1024	Enoyl-CoA hydratase
HS5_05120	COG1250	3-hydroxyacyl-CoA dehydrogenase
HS5_05130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HS5_05140	COG0655	NAD(P)H dehydrogenase (quinone) activity
HS5_05160	COG2079	MmgE PrpD family protein
HS5_05170	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HS5_05180	COG0372	Belongs to the citrate synthase family
HS5_05230	COG1312	Catalyzes the dehydration of D-mannonate
HS5_05240	COG2271	Major facilitator Superfamily
HS5_05250	COG2721	sulfolactate sulfo-lyase activity
HS5_05260	COG2721	sulfolactate sulfo-lyase activity
HS5_05280	COG1802	Transcriptional regulator
HS5_05470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HS5_05510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HS5_05650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_05700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS5_05810	COG0708	Exodeoxyribonuclease III
HS5_05860	COG0602	queuosine metabolic process
HS5_05990	COG1968	undecaprenyl-diphosphatase activity
HS5_06030	COG1489	DNA binding
HS5_06100	COG0656	L-ascorbic acid biosynthetic process
HS5_06270	COG3842	ATPase activity
HS5_06590	COG0531	amino acid
HS5_06620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HS5_06840	COG0515	serine threonine protein kinase
HS5_06840	COG2815	serine threonine protein kinase
HS5_06880	COG3387	PFAM Glycoside hydrolase 15-related
HS5_06890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HS5_07170	COG2271	Major facilitator Superfamily
HS5_07220	COG2329	Antibiotic biosynthesis monooxygenase
HS5_07340	COG1373	ATPase (AAA superfamily
HS5_07350	COG1013	pyruvate-flavodoxin oxidoreductase activity
HS5_07390	COG0531	amino acid
HS5_07400	COG2814	Major facilitator Superfamily
HS5_07410	COG0277	FAD linked oxidase domain protein
HS5_07630	COG0409	Hydrogenase expression formation protein
HS5_07650	COG0309	Hydrogenase expression formation protein (HypE)
HS5_08040	COG1131	(ABC) transporter
HS5_08100	COG0393	Putative heavy-metal-binding
HS5_08110	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HS5_08190	COG4139	cobalamin transport
HS5_08200	COG1119	ATPase activity
HS5_08240	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HS5_08340	COG3383	formate dehydrogenase (NAD+) activity
HS5_08420	COG1131	(ABC) transporter
HS5_08460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HS5_08480	COG2271	Major facilitator Superfamily
HS5_08670	COG2860	membrane
HS5_08740	COG1139	Iron-sulfur cluster binding protein
HS5_08780	COG1042	CoA-binding domain protein
HS5_08780	COG0045	succinate-CoA ligase (ADP-forming) activity
HS5_08780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HS5_08810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HS5_08820	COG0531	amino acid
HS5_08830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HS5_08840	COG1063	alcohol dehydrogenase
HS5_08860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HS5_08900	COG1129	ABC transporter
HS5_08940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HS5_08950	COG0066	3-isopropylmalate dehydratase activity
HS5_08960	COG0778	Nitroreductase
HS5_08970	COG0778	Nitroreductase
HS5_09040	COG0708	Exodeoxyribonuclease III
HS5_09070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HS5_09110	COG0157	Belongs to the NadC ModD family
HS5_09120	COG0519	Catalyzes the synthesis of GMP from XMP
HS5_09140	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HS5_09200	COG1515	deoxyribonuclease V activity
HS5_09210	COG1335	isochorismatase
HS5_09230	COG0450	alkyl hydroperoxide reductase
HS5_09260	COG0372	Belongs to the citrate synthase family
HS5_09300	COG4581	dead DEAH box helicase
HS5_09320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HS5_09340	COG0439	Biotin carboxylase
HS5_09400	COG0444	Belongs to the ABC transporter superfamily
HS5_09430	COG0601	transmembrane transport
HS5_09440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HS5_09530	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HS5_09540	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HS5_09570	COG0189	ligase activity
HS5_09570	COG0569	domain protein
HS5_09580	COG1522	sequence-specific DNA binding
HS5_09610	COG1446	asparaginase
HS5_09680	COG0647	UMP catabolic process
HS5_09690	COG1053	succinate dehydrogenase
HS5_09710	COG2048	Heterodisulfide reductase, subunit B
HS5_09730	COG2304	oxidoreductase activity
HS5_09740	COG0714	Associated with various cellular activities
HS5_09770	COG0303	'Molybdopterin
HS5_09780	COG0083	homoserine kinase activity
HS5_09790	COG0626	cystathionine gamma-synthase activity
HS5_09870	COG0183	Belongs to the thiolase family
HS5_09880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HS5_09920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HS5_09950	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HS5_09960	COG1215	transferase activity, transferring glycosyl groups
HS5_09980	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HS5_09990	COG0351	phosphomethylpyrimidine kinase
HS5_10060	COG1131	(ABC) transporter
HS5_10110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HS5_10120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HS5_10180	COG0720	synthase
HS5_10210	COG0492	ferredoxin-NADP+ reductase activity
HS5_10230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_10260	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HS5_10270	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HS5_10270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HS5_10280	COG0346	lactoylglutathione lyase activity
HS5_10290	COG0071	Belongs to the small heat shock protein (HSP20) family
HS5_10340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HS5_10380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HS5_10380	COG1648	precorrin-2 dehydrogenase activity
HS5_10460	COG1063	alcohol dehydrogenase
HS5_10470	COG0430	RNA-3'-phosphate cyclase activity
HS5_10500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS5_10520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HS5_10680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HS5_10700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HS5_10750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HS5_10750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HS5_10760	COG0469	pyruvate kinase activity
HS5_10780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HS5_10820	COG0297	glycogen (starch) synthase activity
HS5_10880	COG1250	3-hydroxyacyl-CoA dehydrogenase
HS5_10890	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HS5_11610	COG4133	protoheme IX ABC transporter activity
HS5_11670	COG0644	oxidoreductase
HS5_11680	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HS5_11710	COG2368	4-hydroxyphenylacetate
HS5_11720	COG2271	Major facilitator Superfamily
HS5_11730	COG0179	Fumarylacetoacetate (FAA) hydrolase
HS5_11750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HS5_11760	COG0656	L-ascorbic acid biosynthetic process
HS5_11770	COG0667	Aldo Keto reductase
HS5_11790	COG1131	(ABC) transporter
HS5_11830	COG1063	alcohol dehydrogenase
HS5_11870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HS5_11880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HS5_11880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HS5_11920	COG0488	(ABC) transporter
HS5_11990	COG0735	belongs to the Fur family
HS5_12030	COG0517	IMP dehydrogenase activity
HS5_12030	COG0617	tRNA 3'-terminal CCA addition
HS5_12030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HS5_12050	COG2062	phosphohistidine phosphatase, SixA
HS5_12080	COG3118	belongs to the thioredoxin family
HS5_12100	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HS5_12200	COG0492	ferredoxin-NADP+ reductase activity
HS5_12240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HS5_12280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HS5_12300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HS5_12340	COG0561	phosphatase activity
HS5_12360	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HS5_12370	COG0537	adenosine 5'-monophosphoramidase activity
HS5_12400	COG3253	May function as heme-dependent peroxidase
HS5_12430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HS5_12440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HS5_12440	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HS5_12470	COG2890	protein-(glutamine-N5) methyltransferase activity
HS5_12480	COG1695	Transcriptional regulator
HS5_12550	COG0538	isocitrate dehydrogenase activity
HS5_12580	COG2154	pterin-4-alpha-carbinolamine dehydratase
HS5_12630	COG0330	HflC and HflK could
HS5_12750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HS5_12760	COG1028	Short-chain dehydrogenase reductase Sdr
HS5_12770	COG1331	Highly conserved protein containing a thioredoxin domain
HS5_12850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HS5_12860	COG0438	transferase activity, transferring glycosyl groups
HS5_12900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HS5_12910	COG1024	Enoyl-CoA hydratase
HS5_13020	COG1192	Involved in chromosome partitioning
HS5_13050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HS5_13080	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HS5_13170	COG0438	transferase activity, transferring glycosyl groups
HS5_13180	COG0513	Belongs to the DEAD box helicase family
HS5_13200	COG1215	transferase activity, transferring glycosyl groups
HS5_13210	COG1215	transferase activity, transferring glycosyl groups
HS5_13290	COG0243	molybdopterin cofactor binding
HS5_13360	COG0301	tRNA thio-modification
HS5_13360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HS5_13410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_13420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS5_13440	COG1013	pyruvate-flavodoxin oxidoreductase activity
HS5_13520	COG4555	ABC transporter
HS5_13590	COG1131	(ABC) transporter
HS5_13620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HS5_13680	COG0477	Major facilitator Superfamily
HS5_13800	COG4946	Tricorn protease homolog
HS5_13800	COG1506	peptidase
HS5_13800	COG0823	Involved in the tonB-independent uptake of proteins
HS5_13820	COG1573	uracil-dna glycosylase
HS5_13880	COG0586	Pfam SNARE associated Golgi protein
HS5_13910	COG1028	Short-chain dehydrogenase reductase Sdr
HS5_13960	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HS5_13960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HS5_13990	COG0561	phosphatase activity
HS5_14000	COG2271	Major facilitator Superfamily
HS5_14280	COG0393	Putative heavy-metal-binding
HS5_14380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HS5_14390	COG0531	amino acid
HS5_14450	COG0601	transmembrane transport
HS5_14470	COG0444	Belongs to the ABC transporter superfamily
HS5_14480	COG4608	Belongs to the ABC transporter superfamily
HS5_14510	COG0650	Formate hydrogenlyase subunit 4
HS5_14530	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HS5_14540	COG0649	NAD binding
HS5_14550	COG0651	ATP synthesis coupled electron transport
HS5_14560	COG0477	Major facilitator Superfamily
HS5_14620	COG0495	leucyl-tRNA aminoacylation
HS5_14670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HS5_14700	COG2814	Major facilitator Superfamily
HS5_14960	COG1846	Transcriptional regulator
HS5_14970	COG0477	Major facilitator Superfamily
HS5_15020	COG0375	protein maturation
HS5_15050	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HS5_15120	COG2239	Acts as a magnesium transporter
HS5_15200	COG0243	molybdopterin cofactor binding
HS5_15230	COG2226	methyltransferase
HS5_15240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HS5_15270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HS5_15440	COG4948	Mandelate Racemase Muconate Lactonizing
HS5_15460	COG3387	PFAM Glycoside hydrolase 15-related
HS5_15470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HS5_15550	COG2226	methyltransferase
HS5_15560	COG0531	amino acid
HS5_15570	COG1012	belongs to the aldehyde dehydrogenase family
HS5_15720	COG1175	transmembrane transport
HS5_15730	COG3833	ABC-type maltose transport systems, permease component
HS5_15740	COG3842	ATPase activity
HS5_15760	COG0459	protein refolding
HS5_15860	COG1305	Transglutaminase-like
HS5_15870	COG2308	Evidence 4 Homologs of previously reported genes of
HS5_15880	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HS5_15880	COG0674	pyruvate-flavodoxin oxidoreductase activity
HS5_15890	COG1013	pyruvate-flavodoxin oxidoreductase activity
HS5_15910	COG0450	alkyl hydroperoxide reductase
HS5_15920	COG0693	protein deglycase activity
HS5_15940	COG0517	IMP dehydrogenase activity
HS5_15940	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HS5_15950	COG0372	Belongs to the citrate synthase family
HS5_15960	COG1960	acyl-CoA dehydrogenase activity
HS5_15980	COG0039	L-malate dehydrogenase activity
HS5_16070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HS5_16080	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HS5_16120	COG1401	restriction endodeoxyribonuclease activity
HS5_16250	COG0277	FAD linked oxidase domain protein
HS5_16280	COG0513	Belongs to the DEAD box helicase family
HS5_16480	COG1203	CRISPR-associated helicase, Cas3
HS5_16740	COG1131	(ABC) transporter
HS5_16820	COG1131	(ABC) transporter
HS5_16830	COG1131	(ABC) transporter
HS5_16950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HS5_17020	COG1024	Enoyl-CoA hydratase
HS5_17030	COG1960	acyl-CoA dehydrogenase activity
HS5_17040	COG0318	PFAM AMP-dependent synthetase and ligase
HS5_17100	COG2301	Belongs to the HpcH HpaI aldolase family
HS5_17120	COG1832	CoA-binding protein
HS5_17130	COG0813	purine-nucleoside phosphorylase activity
HS5_17150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HS5_17160	COG1584	GPR1 FUN34 yaaH family protein
HS5_17170	COG3608	succinylglutamate desuccinylase aspartoacylase
HS5_17170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HS5_17180	COG0281	malic enzyme
HS5_17230	COG0318	PFAM AMP-dependent synthetase and ligase
HS5_17240	COG1028	Short-chain dehydrogenase reductase Sdr
HS5_17260	COG2814	Major facilitator Superfamily
HS5_17320	COG0531	amino acid
HS5_17330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HS5_17340	COG1132	(ABC) transporter
HS5_17550	COG0519	Catalyzes the synthesis of GMP from XMP
HS5_17560	COG1473	amidohydrolase
HS5_17570	COG0402	S-adenosylhomocysteine deaminase activity
HS5_17590	COG0813	purine-nucleoside phosphorylase activity
HS5_17600	COG0832	Belongs to the urease beta subunit family
HS5_17600	COG0831	urea catabolic process
HS5_17610	COG0804	urea catabolic process
HS5_17620	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HS5_17640	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HS5_17660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HS5_17680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HS5_17690	COG0174	glutamine synthetase
HS5_17730	COG0402	S-adenosylhomocysteine deaminase activity
HS5_17760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HS5_17880	COG1953	Uracil, thiamine, allantoin
HS5_17920	COG1505	serine-type exopeptidase activity
HS5_17950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HS5_17980	COG2814	Major facilitator Superfamily
HS5_17990	COG0671	phosphoesterase, PA-phosphatase related
HS5_18030	COG0531	amino acid
HS5_18120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HS5_18160	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HS5_18180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HS5_18190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HS5_18210	COG0588	phosphoglycerate mutase activity
HS5_18230	COG2271	Major facilitator Superfamily
HS5_18240	COG0535	radical SAM domain protein
HS5_18250	COG1473	amidohydrolase
HS5_18280	COG0174	glutamine synthetase
HS5_18300	COG1011	Hydrolase
HS5_18320	COG0477	Major facilitator Superfamily
HS5_18420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HS5_18470	COG1960	acyl-CoA dehydrogenase activity
HS5_18480	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HS5_18560	COG2222	sugar isomerase
HS5_18580	COG1051	belongs to the nudix hydrolase family
HS5_18600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HS5_18620	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HS5_18630	COG1028	Short-chain dehydrogenase reductase Sdr
HS5_18640	COG1573	uracil-dna glycosylase
HS5_18700	COG0475	glutathione-regulated potassium exporter activity
HS5_18710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HS5_18740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HS5_18810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HS5_18820	COG1881	PFAM PEBP family protein
HS5_18840	COG2255	four-way junction helicase activity
HS5_18850	COG0315	cyclic pyranopterin monophosphate synthase activity
HS5_18970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HS5_19010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HS5_19020	COG1444	tRNA N-acetyltransferase activity
HS5_19050	COG0589	response to stress
HS5_19060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS5_19070	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HS5_19070	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HS5_19080	COG0009	L-threonylcarbamoyladenylate synthase
HS5_19090	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HS5_19100	COG2379	hydroxypyruvate reductase
HS5_19120	COG1321	iron dependent repressor
HS5_19160	COG2226	methyltransferase
HS5_19190	COG0303	'Molybdopterin
HS5_19200	COG0746	molybdenum cofactor guanylyltransferase activity
HS5_19230	COG0402	S-adenosylhomocysteine deaminase activity
HS5_19290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HS5_19370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HS5_19400	COG1201	RNA secondary structure unwinding
HS5_19420	COG0617	tRNA 3'-terminal CCA addition
HS5_19420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HS5_19420	COG3620	sequence-specific DNA binding
HS5_19470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HS5_19480	COG1058	Belongs to the CinA family
HS5_19480	COG1546	Belongs to the CinA family
HS5_19520	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HS5_19530	COG0024	Methionine aminopeptidase
HS5_19570	COG0561	phosphatase activity
HS5_19580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HS5_19600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HS5_19610	COG1047	Peptidyl-prolyl cis-trans
HS5_19620	COG0371	Dehydrogenase
HS5_19630	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HS5_19650	COG0028	Belongs to the TPP enzyme family
HS5_19680	COG0017	Asparaginyl-tRNA synthetase
HS5_19690	COG0585	pseudouridine synthase activity
HS5_19730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_19750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HS5_19760	COG1648	precorrin-2 dehydrogenase activity
HS5_19760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HS5_19770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HS5_19780	COG0113	porphobilinogen synthase activity
HS5_19790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HS5_19800	COG0181	hydroxymethylbilane synthase activity
HS5_19850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HS5_19870	COG1793	dna ligase
HS5_19880	COG0717	Belongs to the dCTP deaminase family
HS5_19910	COG2078	PFAM AMMECR1 domain protein
HS5_19970	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HS5_20000	COG0504	CTP synthase activity
HS5_20010	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HS5_20050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HS5_20090	COG0509	glycine decarboxylation via glycine cleavage system
HS5_20110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HS5_20130	COG0095	Lipoate-protein ligase
HS5_20220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HS5_20230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HS5_20250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HS5_20260	COG0142	geranyltranstransferase activity
HS5_20270	COG1304	FMN binding
HS5_20280	COG0528	UMP kinase activity
HS5_20300	COG1355	regulation of microtubule-based process
HS5_20310	COG0052	Belongs to the universal ribosomal protein uS2 family
HS5_20330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HS5_20340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HS5_20350	COG0200	Binds to the 23S rRNA
HS5_20370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HS5_20380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HS5_20390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HS5_20430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HS5_20450	COG0417	DNA replication proofreading
HS5_20510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HS5_20520	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HS5_20570	COG0023	Translation Initiation Factor
HS5_20590	COG0423	glycine-tRNA ligase activity
HS5_20650	COG0163	prenyltransferase activity
HS5_20660	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HS5_20690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HS5_20710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HS5_20720	COG0667	Aldo Keto reductase
HS5_20810	COG1110	DNA topoisomerase II activity
HS5_20820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_20830	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HS5_20860	COG0557	exoribonuclease II activity
HS5_20930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HS5_20960	COG1797	cobyrinic acid a,c-diamide synthase activity
HS5_20990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HS5_20990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HS5_21010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HS5_21080	COG1201	RNA secondary structure unwinding
HS5_21100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HS5_21120	COG2813	Specifically methylates the guanine in position
HS5_21130	COG0051	transcription antitermination factor activity, RNA binding
HS5_21140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HS5_21150	COG0049	tRNA binding
HS5_21200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HS5_21210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HS5_21220	COG0085	RNA polymerase activity
HS5_21240	COG0281	malic enzyme
HS5_21250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HS5_21260	COG0105	UTP biosynthetic process
HS5_21280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HS5_21300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HS5_21310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HS5_21340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HS5_21350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HS5_21370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HS5_21400	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HS5_21410	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HS5_21420	COG1522	sequence-specific DNA binding
HS5_21430	COG0077	Prephenate dehydratase
HS5_21440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HS5_21480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HS5_21480	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HS5_21510	COG1051	belongs to the nudix hydrolase family
HS5_21510	COG1056	cytidyltransferase-related domain
HS5_21520	COG1607	acyl-coa hydrolase
HS5_21600	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HS5_21630	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HS5_21640	COG1121	(ABC) transporter
HS5_21650	COG1980	fructose-bisphosphate aldolase activity
HS5_21730	COG0124	histidyl-tRNA synthetase
HS5_21770	COG0343	queuine tRNA-ribosyltransferase activity
HS5_21800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_21820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HS5_21880	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HS5_21920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HS5_21930	COG2264	protein methyltransferase activity
HS5_21940	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HS5_21970	COG0012	GTP binding
HS5_22050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HS5_22060	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HS5_22110	COG0322	excinuclease ABC activity
HS5_22120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HS5_22130	COG0546	phosphoglycolate phosphatase activity
HS5_22160	COG0473	3-isopropylmalate dehydrogenase activity
HS5_22170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HS5_22190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HS5_22220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HS5_22230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HS5_22240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HS5_22250	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HS5_22260	COG0255	Belongs to the universal ribosomal protein uL29 family
HS5_22290	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HS5_22300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HS5_22320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HS5_22340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HS5_22350	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HS5_22390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HS5_22410	COG0200	Binds to the 23S rRNA
HS5_22420	COG0201	protein transport
HS5_22450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HS5_22550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HS5_22580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HS5_22590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HS5_22620	COG0189	ligase activity
HS5_22630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HS5_22640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HS5_22650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HS5_22680	COG0114	fumarate hydratase activity
HS5_22710	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HS5_22710	COG0517	IMP dehydrogenase activity
HS5_22770	COG0149	triose-phosphate isomerase activity
HS5_22800	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HS5_22810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HS5_22870	COG0515	serine threonine protein kinase
HS5_22870	COG2815	serine threonine protein kinase
HS5_22890	COG0251	oxidation-reduction process
HS5_22920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HS5_22920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HS5_22950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HS5_22970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HS5_23020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HS5_23070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HS5_23130	COG0543	2 iron, 2 sulfur cluster binding
HS5_23130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HS5_23160	COG0668	transmembrane transport
HS5_23220	COG1720	tRNA m6t6A37 methyltransferase activity
HS5_23270	COG0037	tRNA processing
HS5_23390	COG1506	peptidase
HS5_23390	COG0823	Involved in the tonB-independent uptake of proteins
HS5_23390	COG4946	Tricorn protease homolog
HS5_23430	COG2409	Drug exporters of the RND superfamily
HS5_23500	COG0489	protein tyrosine kinase activity
HS5_23530	COG1280	lysine exporter protein (LysE YggA)
HS5_23600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HS5_23720	COG1024	Enoyl-CoA hydratase
HS5_23730	COG0183	Belongs to the thiolase family
HS5_23840	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HS5_23850	COG3830	Belongs to the UPF0237 family
HS5_23860	COG2848	UPF0210 protein
HS5_23880	COG0438	transferase activity, transferring glycosyl groups
HS5_23970	COG1584	GPR1 FUN34 yaaH family protein
HS5_23980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HS5_24010	COG2814	Major facilitator Superfamily
HS5_24140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HS5_24160	COG1131	(ABC) transporter
HS5_24180	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HS5_24260	COG0501	Belongs to the peptidase M48B family
HS5_24310	COG0477	Major facilitator Superfamily
HS5_24370	COG1592	Rubrerythrin
HS5_24410	COG0450	alkyl hydroperoxide reductase
HS5_24430	COG1215	transferase activity, transferring glycosyl groups
HS5_24450	COG0352	thiamine-phosphate diphosphorylase activity
HS5_24450	COG0351	phosphomethylpyrimidine kinase
HS5_24460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS5_24470	COG0123	including yeast histone deacetylase and acetoin utilization protein
HS5_24510	COG1234	tRNA 3'-trailer cleavage
HS5_24520	COG0006	proline dipeptidase activity
HS5_24570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HS5_24590	COG0501	Belongs to the peptidase M48B family
HS5_24600	COG1063	alcohol dehydrogenase
HS5_24640	COG0519	Catalyzes the synthesis of GMP from XMP
HS5_24650	COG0501	Belongs to the peptidase M48B family
HS5_24710	COG1830	Aldolase
HS5_24750	COG0405	Gamma-glutamyltransferase
HS5_24780	COG1444	tRNA N-acetyltransferase activity
HS5_24820	COG0589	response to stress
HS5_24850	COG0864	Transcriptional regulator
HS5_24870	COG0460	homoserine dehydrogenase
HS5_24880	COG0109	protoheme IX farnesyltransferase activity
HS5_24880	COG1612	heme a metabolic process
HS5_24900	COG1024	Enoyl-CoA hydratase
HS5_24980	COG1250	3-hydroxyacyl-CoA dehydrogenase
HS5_25000	COG0189	ligase activity
HS5_25010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HS5_25030	COG0165	Argininosuccinate lyase
HS5_25040	COG0137	argininosuccinate synthase activity
HS5_25070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HS5_25080	COG0151	Belongs to the GarS family
HS5_25090	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HS5_25100	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HS5_25110	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HS5_25120	COG0047	phosphoribosylformylglycinamidine synthase activity
HS5_25130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HS5_25140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HS5_25140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HS5_25150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HS5_25240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HS5_25250	COG0540	Belongs to the ATCase OTCase family
HS5_25260	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HS5_25290	COG0167	dihydroorotate dehydrogenase activity
HS5_25320	COG2095	MarC family integral membrane protein
HS5_25330	COG1522	sequence-specific DNA binding
HS5_25360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HS5_25370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HS5_25380	COG2151	metal-sulfur cluster biosynthetic enzyme
HS5_25400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HS5_25420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HS5_25430	COG0107	imidazoleglycerol-phosphate synthase activity
HS5_25440	COG0131	Imidazoleglycerol-phosphate dehydratase
HS5_25450	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HS5_25460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HS5_25470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HS5_25490	COG0495	leucyl-tRNA aminoacylation
HS5_25500	COG2096	Adenosyltransferase
HS5_25510	COG0037	tRNA processing
HS5_25530	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HS5_25560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HS5_25580	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HS5_25590	COG0546	phosphoglycolate phosphatase activity
HS5_25600	COG0028	Belongs to the TPP enzyme family
HS5_25650	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HS5_25660	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HS5_25680	COG0442	prolyl-tRNA aminoacylation
HS5_25730	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HS5_25770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HS5_25810	COG2264	protein methyltransferase activity
HS5_25830	COG0417	DNA replication proofreading
HS5_25850	COG1260	myo-inositol-1-phosphate synthase
HS5_25860	COG1007	ATP synthesis coupled electron transport
HS5_25870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HS5_25880	COG0713	ATP synthesis coupled electron transport
HS5_25900	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HS5_25910	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HS5_25920	COG0649	NAD binding
HS5_25930	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HS5_25950	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HS5_25990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HS5_26060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HS5_26070	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HS5_26080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HS5_26120	COG0083	homoserine kinase activity
HS5_26130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HS5_26140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HS5_26150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HS5_26160	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HS5_26170	COG0077	Prephenate dehydratase
HS5_26170	COG1605	Chorismate mutase
HS5_26180	COG3958	Transketolase
HS5_26190	COG3959	Transketolase, thiamine diphosphate binding domain
HS5_26300	COG0067	glutamate synthase
HS5_26310	COG0069	glutamate synthase activity
HS5_26350	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HS5_26470	COG1185	polyribonucleotide nucleotidyltransferase activity
HS5_26510	COG0477	Major facilitator Superfamily
HS5_26590	COG0725	ABC transporter, periplasmic molybdate-binding protein
HS5_26600	COG0300	oxidoreductase activity
HS5_26610	COG0084	hydrolase, TatD family'
HS5_26670	COG0535	radical SAM domain protein
HS5_26680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HS5_26690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HS5_26690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HS5_26710	COG0318	PFAM AMP-dependent synthetase and ligase
HS5_26720	COG3118	belongs to the thioredoxin family
HS5_26730	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HS5_26740	COG0174	glutamine synthetase
HS5_26760	COG0302	gtp cyclohydrolase
HS5_26780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HS5_26930	COG0552	protein localization to endoplasmic reticulum
HS5_26960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HS5_27000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HS5_27020	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HS5_27030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HS5_27070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HS5_27100	COG0126	phosphoglycerate kinase activity
HS5_27140	COG2814	Major facilitator Superfamily
HS5_27140	COG0477	Major facilitator Superfamily
HS5_27320	COG0396	ATPase activity
HS5_27360	COG0509	glycine decarboxylation via glycine cleavage system
HS5_27370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HS5_27380	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HS5_27390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HS5_27460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_27470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HS5_27500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HS5_27580	COG0525	valine-tRNA ligase activity
HS5_27590	COG0436	Aminotransferase
HS5_27600	COG0134	indole-3-glycerol-phosphate synthase activity
HS5_27610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HS5_27610	COG0512	Glutamine amidotransferase of anthranilate synthase
HS5_27620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HS5_27630	COG0135	phosphoribosylanthranilate isomerase activity
HS5_27650	COG0159	tryptophan synthase activity
HS5_27660	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HS5_27670	COG1254	Belongs to the acylphosphatase family
HS5_27690	COG0574	Belongs to the PEP-utilizing enzyme family
HS5_27690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HS5_27720	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HS5_27740	COG0527	aspartate kinase activity
HS5_27750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HS5_27780	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HS5_27850	COG0459	protein refolding
HS5_27900	COG0018	arginyl-trna synthetase
HS5_27930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HS5_27960	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HS5_27970	COG0252	asparaginase activity
HS5_28030	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
HS5_28130	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HS5_28130	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HS5_28160	COG0154	amidase activity
HS5_28180	COG1324	tolerance protein
HS5_28200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HS5_28250	COG1110	DNA topoisomerase II activity
HS5_28270	COG0514	ATP-dependent DNA helicase (RecQ)
HS5_28330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HS5_28340	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HS5_28360	COG2084	Dehydrogenase
HS5_28400	COG0528	UMP kinase activity
HS5_28420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)