locus-tag	class	description
C4901_00010	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
C4901_00015	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
C4901_00020	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
C4901_00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C4901_00035	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
C4901_00040	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
C4901_00045	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
C4901_00110	ENOG4105CEN	a g-specific adenine glycosylase
C4901_00115	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
C4901_00120	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
C4901_00165	ENOG4105DY2	Paraquat-inducible protein b
C4901_00170	ENOG4105F1S	paraquat-inducible protein a
C4901_00175	ENOG4105E2S	oxidase) subunit II
C4901_00180	ENOG4105BZ9	Cytochrome C oxidase, subunit I
C4901_00185	ENOG4105CCU	oxidase (Subunit III)
C4901_00200	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
C4901_00205	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
C4901_00215	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
C4901_00230	ENOG4105BZS	acriflavin resistance protein
C4901_00245	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
C4901_00250	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
C4901_00265	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
C4901_00270	ENOG4105D16	lipopolysaccharide heptosyltransferase i
C4901_00275	ENOG4106WTF	Glycosyl transferase, family 2
C4901_00325	ENOG4105D16	lipopolysaccharide heptosyltransferase i
C4901_00330	ENOG4107SBE	Glycosyl transferase (Group 1
C4901_00335	ENOG4105DKP	glycosyl transferase, family 9
C4901_00345	ENOG41089I4	Inherit from COG: Glycosyl transferase, family 2
C4901_00390	ENOG4105DBI	uridine monophosphokinase
C4901_00395	ENOG4105XA0	heptosyltransferase ii
C4901_00405	ENOG4105CM2	brancheD-chain amino acid aminotransferase
C4901_00415	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
C4901_00420	ENOG4105K63	Thioredoxin
C4901_00430	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
C4901_00435	ENOG4107RAT	Ribulose bisphosphate carboxylase large chain, catalytic domain
C4901_00440	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
C4901_00490	ENOG4108KHN	disulfide isomerase, thiol-disulfide oxidase
C4901_00495	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
C4901_00500	ENOG4105C12	Phosphoribosylglycinamide synthetase
C4901_00505	ENOG4105DC1	bifunctional purine biosynthesis protein purh
C4901_00510	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
C4901_00515	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
C4901_00525	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
C4901_00530	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
C4901_00535	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
C4901_00540	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
C4901_00545	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4901_00550	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
C4901_00555	ENOG4105VF7	tolerance protein
C4901_00565	ENOG4105FS0	cytoplasmic membrane protein
C4901_00570	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
C4901_00575	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
C4901_00585	ENOG4105C0W	non-ribosomal peptide synthetase
C4901_00590	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
C4901_00600	ENOG4105CHR	reductase
C4901_00660	ENOG4105VCQ	rubredoxin
C4901_00665	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
C4901_00675	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
C4901_00680	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
C4901_00690	ENOG4105BZU	Histidine kinase
C4901_00710	ENOG4105NWN	ApaG protein
C4901_00715	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
C4901_00725	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
C4901_00765	ENOG4105SYT	Methylenetetrahydrofolate reductase
C4901_00770	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
C4901_00775	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
C4901_00780	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
C4901_00785	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
C4901_00795	ENOG4105D1S	lipid A biosynthesis
C4901_00800	ENOG4105WAP	TPR repeat-containing protein
C4901_00805	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
C4901_00810	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
C4901_00815	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
C4901_00825	ENOG4108RPN	Protein smg homolog
C4901_00835	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
C4901_00845	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
C4901_00850	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
C4901_00855	ENOG4105VW4	glutaredoxin 3
C4901_00860	ENOG4107YZP	Rhodanese domain protein
C4901_00870	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
C4901_00875	ENOG41063SB	peptidase
C4901_00880	ENOG4105CN1	protease
C4901_00895	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
C4901_00910	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
C4901_00920	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
C4901_00925	ENOG4105BZU	Histidine kinase
C4901_00945	ENOG4105FDP	GntR family transcriptional regulator
C4901_00955	ENOG4105FDP	GntR family transcriptional regulator
C4901_00975	ENOG4108Z4U	Ferredoxin
C4901_01010	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
C4901_01015	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
C4901_01020	ENOG4105D52	delta-aminolevulinic acid dehydratase
C4901_01025	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
C4901_01035	ENOG4107R15	K00850 6-phosphofructokinase 1 EC 2.7.1.11
C4901_01045	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C4901_01065	ENOG41060GT	Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity)
C4901_01070	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
C4901_01075	ENOG4105CKK	Glycosyl transferase, family 2
C4901_01090	ENOG4105F73	Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
C4901_01095	ENOG4105CQ7	ATP-dependent helicase
C4901_01100	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
C4901_01105	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
C4901_01125	ENOG4108S0S	Nucleotidyl transferase
C4901_01130	ENOG4105EHM	Aminoglycoside phosphotransferase
C4901_01135	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
C4901_01140	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
C4901_01145	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
C4901_01150	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
C4901_01165	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
C4901_01180	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
C4901_01185	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
C4901_01190	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
C4901_01205	ENOG4105C5F	glutamine synthetase
C4901_01220	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
C4901_01280	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
C4901_01290	ENOG4105N5T	Radical SAM Protein
C4901_01295	ENOG4105CFP	Peptidase U32
C4901_01300	ENOG4106RZ4	Peptidase U32
C4901_01335	ENOG4105D4P	Coproporphyrinogen iii oxidase
C4901_01345	ENOG4105EA8	2-Nitropropane dioxygenase
C4901_01355	ENOG4108UT2	hemolysin iii
C4901_01380	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
C4901_01385	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
C4901_01410	ENOG4108Z43	UPF0250 protein
C4901_01425	ENOG4105CNI	cell division protein FtsW
C4901_01430	ENOG4105CJN	penicillin-binding protein
C4901_01435	ENOG4105VQ7	Rod shape-determining protein MreD
C4901_01440	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
C4901_01445	ENOG4105DFF	Rod shape-determining protein mreb
C4901_01450	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
C4901_01455	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
C4901_01460	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
C4901_01505	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
C4901_01525	ENOG4105FAE	von Willebrand factor, type A
C4901_01540	ENOG4105EWK	phytoene
C4901_01555	ENOG41086B8	CoB-CoM heterodisulfide reductase
C4901_01580	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
C4901_01595	ENOG4105D03	DNA-3-methyladenine glycosylase II
C4901_01600	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
C4901_01605	ENOG4105CUX	Signal transduction histidine kinase
C4901_01610	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4901_01625	ENOG4105DHJ	ABC, transporter
C4901_01635	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
C4901_01640	ENOG4105D0A	hydroxylase
C4901_01645	ENOG4107RAQ	aminopeptidase
C4901_01665	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
C4901_01670	ENOG4105D48	metallophosphoesterase
C4901_01690	ENOG4105C7B	Threonine dehydratase
C4901_01700	ENOG4105BZU	Histidine kinase
C4901_01710	ENOG4105E66	phosphoriboisomerase A
C4901_01730	ENOG4108VAU	general secretion pathway protein G
C4901_01755	ENOG4107QHF	type ii secretion system protein e
C4901_01780	ENOG4105GVR	general secretion pathway protein D
C4901_01805	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
C4901_01815	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
C4901_01870	ENOG41083GN	tRNA synthetase class II (g h p and s)
C4901_01885	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C4901_01890	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
C4901_01895	ENOG4105CAK	Cell division ATP-binding protein ftsE
C4901_01900	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
C4901_01905	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
C4901_01910	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
C4901_01915	ENOG4106H78	methyltransferase
C4901_01930	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
C4901_01950	ENOG4105CJ1	ABC, transporter
C4901_01955	ENOG4108EX3	reductase
C4901_01960	ENOG4105PGM	cation diffusion facilitator family transporter
C4901_02075	ENOG41063ZP	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
C4901_02080	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
C4901_02155	ENOG410601J	HemY protein
C4901_02165	ENOG41076E6	Uroporphyrinogen-III Synthase
C4901_02170	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
C4901_02190	ENOG4105D6S	protein involved in catabolism of external DNA
C4901_02200	ENOG41079KZ	Major Facilitator Superfamily
C4901_02205	ENOG4107YZP	Rhodanese domain protein
C4901_02210	ENOG4108VCT	Sulfite exporter TauE/SafE
C4901_02220	ENOG4105CH7	arginosuccinase
C4901_02225	ENOG4108HRK	Histidine kinase
C4901_02230	ENOG4108NEV	two component transcriptional regulator, LytTR family
C4901_02245	ENOG4105D3W	isochorismatase
C4901_02255	ENOG4107SPG	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
C4901_02280	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
C4901_02290	ENOG4105XQ6	frataxin-like protein
C4901_02300	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
C4901_02305	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
C4901_02315	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
C4901_02325	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
C4901_02330	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
C4901_02335	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
C4901_02350	ENOG4105CAS	nag kinase
C4901_02360	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
C4901_02375	ENOG4105D06	uba thif-type nad fad binding protein
C4901_02380	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
C4901_02385	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
C4901_02390	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
C4901_02405	ENOG41081V9	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
C4901_02410	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
C4901_02420	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
C4901_02425	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
C4901_02430	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
C4901_02435	ENOG4105C3G	gtp-binding protein
C4901_02480	ENOG41082AG	Plasmid maintenance system antidote protein
C4901_02515	ENOG4105C0D	helicase
C4901_02535	ENOG4108RS6	transposase
C4901_02570	ENOG4105KJJ	Uncharacterized ACR, COG1993
C4901_02575	ENOG4107R30	NADH dehydrogenase
C4901_02580	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
C4901_02585	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C4901_02590	ENOG4108JPZ	Monovalent cation H antiporter subunit D
C4901_02600	ENOG4107TDF	Formate hydrogenlyase subunit 4
C4901_02605	ENOG41090Y2	cytochrome C
C4901_02620	ENOG4107SVH	Potassium channel protein
C4901_02645	ENOG4105K63	Thioredoxin
C4901_02650	ENOG4107U9T	Pfam:Ribonuclease_BN
C4901_02655	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
C4901_02675	ENOG4108V1T	peptidylprolyl cis-trans isomerase
C4901_02690	ENOG4105CQB	FAD linked oxidase domain protein
C4901_02695	ENOG4105EU8	FAD linked oxidase domain protein
C4901_02700	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
C4901_02715	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
C4901_02720	ENOG4105C9A	Phoh family
C4901_02725	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
C4901_02730	ENOG4108JU5	Magnesium and cobalt efflux protein
C4901_02735	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
C4901_02750	ENOG4105EQR	Transposase IS116 IS110 IS902
C4901_02810	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
C4901_02830	ENOG4105C8T	Leucyl-tRNA synthetase
C4901_02835	ENOG4108U2H	Rare lipoprotein B
C4901_02845	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
C4901_02850	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
C4901_02860	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
C4901_02865	ENOG4108Z03	MAF-like protein
C4901_02870	ENOG4105C03	ribonuclease
C4901_02885	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
C4901_02890	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
C4901_02900	ENOG4107QN2	dihydrolipoyl dehydrogenase
C4901_02960	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
C4901_02965	ENOG41080Z8	PHOSPHOCARRIER protein
C4901_02975	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
C4901_02980	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
C4901_02985	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
C4901_02990	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C4901_02995	ENOG4108IUZ	ABC transporter
C4901_03005	ENOG4107QI1	Mate efflux family protein
C4901_03015	ENOG4105C2X	Arabinose 5-phosphate isomerase
C4901_03025	ENOG4105CJ1	ABC, transporter
C4901_03085	ENOG4105DHJ	ABC, transporter
C4901_03090	ENOG4105CY3	ABC transporter, permease
C4901_03095	ENOG4107PE3	Mammalian cell entry related domain protein
C4901_03110	ENOG4105DA5	(ABC) transporter
C4901_03115	ENOG4105E3A	(ABC) transporter
C4901_03125	ENOG4105M2J	Glutaredoxin
C4901_03130	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
C4901_03135	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
C4901_03140	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
C4901_03145	ENOG4105CIH	Imidazole acetol-phosphate transaminase
C4901_03150	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
C4901_03155	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
C4901_03160	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
C4901_03165	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
C4901_03175	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
C4901_03180	ENOG4105K59	histidine triad (HIT) protein
C4901_03185	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
C4901_03190	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
C4901_03200	ENOG41079KZ	Major Facilitator Superfamily
C4901_03205	ENOG4105BZF	Glycosyl transferase (Group 1
C4901_03215	ENOG4105C0H	protease
C4901_03220	ENOG4107MKT	Stringent starvation protein a
C4901_03225	ENOG4105KB2	stringent starvation protein b
C4901_03250	ENOG4105CQB	FAD linked oxidase domain protein
C4901_03255	ENOG4107Z67	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
C4901_03265	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
C4901_03275	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
C4901_03290	ENOG41090Y2	cytochrome C
C4901_03295	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
C4901_03305	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
C4901_03310	ENOG4105EIX	cytochrome c1
C4901_03315	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
C4901_03320	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
C4901_03330	ENOG4107QF7	multi-drug
C4901_03340	ENOG4105BZU	Histidine kinase
C4901_03345	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
C4901_03355	ENOG4108V6E	Cell division protein mraZ
C4901_03360	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
C4901_03370	ENOG4105CJN	penicillin-binding protein
C4901_03375	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
C4901_03380	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
C4901_03385	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
C4901_03390	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
C4901_03395	ENOG4105CNI	cell division protein FtsW
C4901_03400	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
C4901_03405	ENOG4105DFU	Cell wall formation (By similarity)
C4901_03410	ENOG4105D4A	Cell wall formation (By similarity)
C4901_03415	ENOG4105CPF	Cell wall formation (By similarity)
C4901_03420	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
C4901_03425	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
C4901_03430	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
C4901_03435	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C4901_03445	ENOG4105DR5	peptidase
C4901_03450	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
C4901_03455	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
C4901_03460	ENOG4105M6F	mutator MutT protein
C4901_03495	ENOG4105EKQ	RNA-directed DNA polymerase
C4901_03525	ENOG4108YZN	class I peptide chain release factor
C4901_03545	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4901_03575	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
C4901_03585	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
C4901_03595	ENOG4107QHF	type ii secretion system protein e
C4901_03600	ENOG4108RAC	Rubrerythrin
C4901_03620	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C4901_03625	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C4901_03630	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
C4901_03650	ENOG4107R5R	arsenical pump membrane protein
C4901_03655	ENOG4107R5R	arsenical pump membrane protein
C4901_03665	ENOG4105BZU	Histidine kinase
C4901_03725	ENOG4107R5R	arsenical pump membrane protein
C4901_03730	ENOG4108IAB	Phoh family
C4901_03735	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4901_03740	ENOG4105BZU	Histidine kinase
C4901_03745	ENOG4105BZU	Histidine kinase
C4901_03765	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
C4901_03770	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
C4901_03785	ENOG4105RQ5	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
C4901_03815	ENOG4108JJ7	ABC transporter
C4901_03820	ENOG4105C5H	ABC transporter
C4901_03830	ENOG4105DBV	ornithine carbamoyltransferase
C4901_03835	ENOG4105C8Y	Acetylornithine aminotransferase
C4901_03840	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
C4901_03845	ENOG4108JYK	Dehydrogenase
C4901_03855	ENOG4107QN2	dihydrolipoyl dehydrogenase
C4901_03860	ENOG4105CDH	Citrulline--aspartate ligase
C4901_03865	ENOG4105BZU	Histidine kinase
C4901_03890	ENOG4105CSM	endonuclease III
C4901_03905	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
C4901_03950	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
C4901_03965	ENOG4105D1F	ATP-binding protein
C4901_03970	ENOG4105DHP	deoxycytidine triphosphate deaminase
C4901_03975	ENOG4105F4R	Transcriptional regulator mode
C4901_03990	ENOG4105E2A	Dehydrogenase
C4901_04010	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
C4901_04015	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
C4901_04020	ENOG4105W5Q	DNA repair protein (RadC
C4901_04030	ENOG4108IEG	Formate dehydrogenase Alpha subunit
C4901_04035	ENOG4105KDC	50s ribosomal protein l28
C4901_04040	ENOG4105W0E	50S ribosomal protein L33
C4901_04075	ENOG4105EMN	RNA polymerase sigma factor
C4901_04080	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
C4901_04085	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
C4901_04090	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
C4901_04095	ENOG4105C02	permease
C4901_04105	ENOG4105CS1	NAD(P)H quinone oxidoreductase
C4901_04110	ENOG4108IJ0	Aspartate ammonia-lyase
C4901_04120	ENOG4105FQ6	thiopurine methyltransferase
C4901_04150	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
C4901_04160	ENOG4105C57	major facilitator superfamily
C4901_04170	ENOG4107TPS	domain protein
C4901_04175	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
C4901_04180	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
C4901_04185	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
C4901_04190	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
C4901_04200	ENOG4105D3R	alkyl hydroperoxide reductase
C4901_04205	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
C4901_04220	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
C4901_04270	ENOG4105DKQ	ROK family
C4901_04275	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
C4901_04280	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
C4901_04290	ENOG4105CW7	secretion protein, HlyD family
C4901_04300	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
C4901_04305	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
C4901_04310	ENOG4105CTB	Polyprenyl synthetase
C4901_04315	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
C4901_04325	ENOG4105F0N	pyrophosphate phospho-hydrolase
C4901_04395	ENOG4107SET	aldo keto reductase
C4901_04410	ENOG4105DQ4	alcohol dehydrogenase
C4901_04415	ENOG4105EQ2	LysR family Transcriptional regulator
C4901_04425	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
C4901_04435	ENOG4108Z1B	Cyclase dehydrase
C4901_04445	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
C4901_04450	ENOG41090R7	Ferric uptake
C4901_04455	ENOG4108EKC	n-acetylglutamate synthase
C4901_04460	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
C4901_04465	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
C4901_04470	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
C4901_04475	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4901_04480	ENOG4105CFG	Acts as a chaperone (By similarity)
C4901_04485	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
C4901_04495	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
C4901_04500	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
C4901_04505	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
C4901_04510	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
C4901_04520	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
C4901_04525	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
C4901_04530	ENOG4105EEI	dihydropteroate synthase
C4901_04535	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
C4901_04540	ENOG4105CP7	Triose-phosphate isomerase
C4901_04545	ENOG4107EJC	Preprotein translocase subunit SecG
C4901_04555	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C4901_04560	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C4901_04565	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C4901_04570	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C4901_04585	ENOG4108IEH	NADH dehydrogenase subunit g
C4901_04585	ENOG4108IEH	NADH dehydrogenase subunit g
C4901_04590	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
C4901_04595	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C4901_04600	ENOG4105DF2	NADH dehydrogenase subunit j
C4901_04605	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C4901_04615	ENOG4105C8S	subunit m
C4901_04620	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C4901_04655	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
C4901_04660	ENOG4105CHV	Transcription elongation factor NusA
C4901_04665	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
C4901_04670	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
C4901_04680	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
C4901_04685	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
C4901_04700	ENOG4105DNZ	Alpha Beta Hydrolase
C4901_04705	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
C4901_04710	ENOG4107T5V	SNARE associated Golgi
C4901_04715	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C4901_04720	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
C4901_04725	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
C4901_04730	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
C4901_04735	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
C4901_04740	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
C4901_04750	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
C4901_04755	ENOG4105E2S	oxidase) subunit II
C4901_04760	ENOG4105BZ9	Cytochrome C oxidase, subunit I
C4901_04765	ENOG4105CCU	oxidase (Subunit III)
C4901_04780	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
C4901_04785	ENOG4105HF0	Membrane
C4901_04795	ENOG4105BZP	glycoside hydrolase 15-related
C4901_04850	ENOG4105BZU	Histidine kinase
C4901_04860	ENOG4105BZU	Histidine kinase
C4901_04910	ENOG4105WJ3	XRE family Transcriptional regulator
C4901_04915	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
C4901_04935	ENOG4105DQ4	alcohol dehydrogenase
C4901_04955	ENOG4105GVR	general secretion pathway protein D
C4901_04960	ENOG4107QHF	type ii secretion system protein e
C4901_04965	ENOG4105D7Q	type ii secretion system
C4901_04970	ENOG4108VAU	general secretion pathway protein G
C4901_04975	ENOG41069X0	general secretion pathway protein h
C4901_04980	ENOG4105X5Z	General secretion pathway protein I
C4901_04985	ENOG4108WWZ	General secretion pathway protein J
C4901_04990	ENOG4108RTD	type II secretion system protein K
C4901_05020	ENOG4105EQR	Transposase IS116 IS110 IS902
C4901_05025	ENOG4105DZ0	fad dependent oxidoreductase
C4901_05095	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4901_05100	ENOG4107TUY	Histidine kinase
C4901_05115	ENOG4105EAH	synthase
C4901_05120	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
C4901_05125	ENOG4105K46	50S ribosomal protein l27
C4901_05130	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4901_05135	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
C4901_05140	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
C4901_05145	ENOG4105CJR	Integral membrane protein (MviN
C4901_05155	ENOG4105DTN	riboflavin biosynthesis protein ribF
C4901_05160	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
C4901_05170	ENOG4108YZY	peptidylprolyl cis-trans isomerase
C4901_05175	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
C4901_05180	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
C4901_05185	ENOG41090R7	Ferric uptake
C4901_05250	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
C4901_05265	ENOG41065RQ	ADP-ribosylation crystallin J1
C4901_05270	ENOG4108JQC	penicillin-binding protein 1A
C4901_05285	ENOG4107QX8	SPFH domain, Band 7 family protein
C4901_05335	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
C4901_05340	ENOG4108V06	Glutathione peroxidase
C4901_05355	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
C4901_05360	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
C4901_05395	ENOG410901P	UPF0249 protein
C4901_05465	ENOG4108K3A	Glutathione S-transferase
C4901_05475	ENOG4105E2S	oxidase) subunit II
C4901_05480	ENOG4105BZ9	Cytochrome C oxidase, subunit I
C4901_05485	ENOG4105CCU	oxidase (Subunit III)
C4901_05520	ENOG4108K3A	Glutathione S-transferase
C4901_05540	ENOG4105CHM	Aminotransferase
C4901_05545	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
C4901_05565	ENOG4105C22	threonyL-tRNA synthetase
C4901_05570	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
C4901_05575	ENOG41082NX	50s ribosomal protein l35
C4901_05580	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
C4901_05585	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
C4901_05590	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
C4901_05595	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
C4901_05605	ENOG4105KHC	sulfurtransferase
C4901_05620	ENOG4105BZU	Histidine kinase
C4901_05625	ENOG4105CMR	udp-glucose 4-epimerase
C4901_05645	ENOG4105BZU	Histidine kinase
C4901_05690	ENOG4108KMM	Diguanylate cyclase
C4901_05735	ENOG4105DKP	glycosyl transferase, family 9
C4901_05755	ENOG4105BZU	Histidine kinase
C4901_05760	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
C4901_05765	ENOG4105C8V	SAICAR synthetase
C4901_05775	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
C4901_05780	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
C4901_05790	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
C4901_05805	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
C4901_05815	ENOG4105EIN	peptidylprolyl cis-trans isomerase
C4901_05820	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
C4901_05825	ENOG4105E9H	Lytic Murein transglycosylase
C4901_05830	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
C4901_05835	ENOG4105D1A	Methyltransferase
C4901_05840	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
C4901_05845	ENOG4107RZZ	dna polymerase iii epsilon subunit
C4901_05860	ENOG4105BZU	Histidine kinase
C4901_05870	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
C4901_05875	ENOG4108MTB	glycosyl transferase family
C4901_05880	ENOG4105KH3	nitrite reductase (NAD(P)h) small subunit
C4901_05885	ENOG4108IFG	nitrite reductase, (NAD(P)H)
C4901_05890	ENOG4108MN8	Membrane
C4901_05900	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
C4901_05915	ENOG4105CHC	glucokinase (EC 2.7.1.2)
C4901_05920	ENOG4108J5G	6-phosphogluconate dehydrogenase
C4901_05925	ENOG4105C89	phosphohexose isomerase
C4901_05930	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
C4901_05940	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
C4901_05970	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4901_05975	ENOG4107R76	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
C4901_05980	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
C4901_06010	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
C4901_06015	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4901_06035	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
C4901_06040	ENOG4107S9Q	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
C4901_06060	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
C4901_06095	ENOG4105C3J	Cysteine desulfurase
C4901_06120	ENOG4105E2S	oxidase) subunit II
C4901_06130	ENOG4105CCU	oxidase (Subunit III)
C4901_06145	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
C4901_06165	ENOG4106KE4	Dehydrogenase
C4901_06170	ENOG4105DFH	Transport of potassium into the cell (By similarity)
C4901_06185	ENOG4105CMQ	Chloride channel
C4901_06220	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4901_06225	ENOG4105BZU	Histidine kinase
C4901_06230	ENOG4105BZU	Histidine kinase
C4901_06280	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
C4901_06295	ENOG4105BZU	Histidine kinase
C4901_06305	ENOG4105WEF	catalase
C4901_06310	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
C4901_06315	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
C4901_06365	ENOG4105KVH	Transcriptional regulator
C4901_06405	ENOG4105KAK	Plasmid pRiA4b ORF-3 family protein
C4901_06415	ENOG4105CUB	amino acid
C4901_06420	ENOG4105CBC	glutamate synthase
C4901_06430	ENOG4105EYU	Glutamine amido-transferase
C4901_06435	ENOG4105CFQ	glutamine synthetase
C4901_06445	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
C4901_06675	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
C4901_06680	ENOG4107RJ7	Glycosyl transferase (Group 1
C4901_06685	ENOG4108TJN	glycosyl transferase group 1
C4901_06690	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
C4901_06695	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
C4901_06700	ENOG4108KQJ	Type 11 methyltransferase
C4901_06705	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
C4901_06765	ENOG4105CY1	sulfite reductase, dissimilatory-type alpha subunit
C4901_06770	ENOG4105PJW	Sulfite reductase dissimilatory-type beta subunit
C4901_06775	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
C4901_06780	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
C4901_06790	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
C4901_06815	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
C4901_06825	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
C4901_06830	ENOG4107QN2	dihydrolipoyl dehydrogenase
C4901_06840	ENOG4105WH1	Two component transcriptional regulator luxr family
C4901_06845	ENOG4105MEW	serine threonine protein phosphatase
C4901_06875	ENOG4105W2W	Cytotoxic translational repressor of toxin-antitoxin stability system
C4901_06900	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
C4901_06910	ENOG4105W5Q	DNA repair protein (RadC
C4901_06955	ENOG4105E7D	Protein of unknown function (DUF3375)
C4901_06975	ENOG4105DJ9	glucan biosynthesis protein
C4901_06980	ENOG4105DJ9	glucan biosynthesis protein
C4901_06995	ENOG4105N1F	Hnh endonuclease
C4901_07000	ENOG4105VEQ	Cold shock protein
C4901_07005	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
C4901_07010	ENOG4105DJ9	glucan biosynthesis protein
C4901_07030	ENOG4105C1J	atp-dependent rna helicase
C4901_07040	ENOG4105EKQ	RNA-directed DNA polymerase
C4901_07045	ENOG4105BZU	Histidine kinase
C4901_07055	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
C4901_07060	ENOG4108IYU	L-aspartate oxidase
C4901_07065	ENOG4105EMN	RNA polymerase sigma factor
C4901_07080	ENOG4105C0H	protease
C4901_07085	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
C4901_07090	ENOG4105C3F	Signal peptidase i
C4901_07100	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
C4901_07105	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
C4901_07110	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
C4901_07130	ENOG4105X54	addiction module antidote protein
C4901_07135	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
C4901_07150	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
C4901_07155	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
C4901_07160	ENOG4105CPF	Cell wall formation (By similarity)
C4901_07185	ENOG4107SID	ATP-dependent exodnase (exonuclease v)
C4901_07220	ENOG4105C5H	ABC transporter
C4901_07225	ENOG4105CYM	Glutathione S-transferase
C4901_07240	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
C4901_07360	ENOG4105RT5	Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation
C4901_07415	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
C4901_07445	ENOG4108JJA	ABC, transporter
C4901_07465	ENOG4105F5W	AtP-binding protein
C4901_07480	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
C4901_07530	ENOG4105CKK	Glycosyl transferase, family 2
C4901_07535	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
C4901_07540	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
C4901_07610	ENOG4108YZY	peptidylprolyl cis-trans isomerase
C4901_07650	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
C4901_07660	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
C4901_07685	ENOG4107SH3	glycosyl transferase, family 39
C4901_07690	ENOG4105W1N	transcriptional regulator
C4901_07695	ENOG4105C2I	pirin domain protein
C4901_07700	ENOG4105CS1	NAD(P)H quinone oxidoreductase
C4901_07705	ENOG4105KVH	Transcriptional regulator
C4901_07715	ENOG4105C5H	ABC transporter
C4901_07720	ENOG4108ZJ4	polysaccharide deacetylase
C4901_07770	ENOG4105DQ4	alcohol dehydrogenase
C4901_07775	ENOG4107WYG	Transcriptional regulator, luxr family
C4901_07835	ENOG4105CQB	FAD linked oxidase domain protein
C4901_07840	ENOG4105C0H	protease
C4901_07845	ENOG4106BRA	Membrane
C4901_07850	ENOG4105BZU	Histidine kinase
C4901_07860	ENOG4105DUM	transcriptional regulator, lysR family
C4901_07865	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
C4901_07870	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
C4901_07880	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
C4901_07900	ENOG4105BZS	acriflavin resistance protein
C4901_07905	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
C4901_07910	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
C4901_07915	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
C4901_07920	ENOG41081QV	Universal stress protein
C4901_07935	ENOG4105BZU	Histidine kinase
C4901_07940	ENOG4107S5T	Carbohydrate kinase
C4901_07945	ENOG4107YRI	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
C4901_07950	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
C4901_07955	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
C4901_07960	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
C4901_07965	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
C4901_07975	ENOG4105K9H	YciI-like protein
C4901_07985	ENOG4105DB7	PHP domain protein
C4901_07990	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
C4901_07995	ENOG4108Z4T	Peptidase M50
C4901_08000	ENOG4105C31	Tryptophanyl-tRNA synthetase
C4901_08005	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
C4901_08015	ENOG4105FE9	pseudouridine synthase
C4901_08030	ENOG4105K5M	30s ribosomal protein S16
C4901_08035	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
C4901_08040	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
C4901_08045	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
C4901_08050	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
C4901_08065	ENOG4108M8H	domain protein
C4901_08075	ENOG4105C4R	Atp-dependent dna helicase
C4901_08080	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
C4901_08085	ENOG4105D64	Mechanosensitive ion channel
C4901_08095	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
C4901_08100	ENOG4105BZN	citrate synthase
C4901_08105	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
C4901_08110	ENOG4105VEQ	Cold shock protein
C4901_08115	ENOG4105KHU	inner membrane protein YohD
C4901_08145	ENOG4105D7V	transposase
C4901_08155	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
C4901_08165	ENOG4105DWY	Agmatine deiminase
C4901_08205	ENOG4105FE9	pseudouridine synthase
C4901_08210	ENOG4105C01	Dihydroxy-acid dehydratase
C4901_08220	ENOG4105X23	Endonuclease Exonuclease phosphatase
C4901_08225	ENOG4105DZQ	phospholipase D Transphosphatidylase
C4901_08235	ENOG4108ZKH	Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity)
C4901_08245	ENOG4107QTF	adenylosuccinate lyase
C4901_08255	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
C4901_08265	ENOG4108R99	pseudouridine synthase
C4901_08290	ENOG4105VEQ	Cold shock protein
C4901_08295	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
C4901_08300	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
C4901_08310	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
C4901_08315	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
C4901_08320	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
C4901_08340	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
C4901_08350	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
C4901_08355	ENOG4105C4K	Nad synthetase
C4901_08360	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4901_08365	ENOG4105C34	Pseudouridine synthase
C4901_08370	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
C4901_08375	ENOG4108Z0Z	intracellular protease Pfpi family
C4901_08380	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
C4901_08385	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
C4901_08405	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
C4901_08410	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
C4901_08415	ENOG4105NAU	thioesterase Superfamily protein
C4901_08425	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
C4901_08430	ENOG4105D8G	Major Facilitator superfamily
C4901_08440	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
C4901_08445	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
C4901_08450	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
C4901_08455	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
C4901_08470	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
C4901_08485	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
C4901_08525	ENOG4105EQR	Transposase IS116 IS110 IS902
C4901_08545	ENOG4108IYH	Dna topoisomerase
C4901_08575	ENOG4105CJN	penicillin-binding protein
C4901_08585	ENOG4107RSM	transcriptional regulator
C4901_08595	ENOG4105BZU	Histidine kinase
C4901_08600	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
C4901_08605	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
C4901_08610	ENOG4108JPZ	Monovalent cation H antiporter subunit D
C4901_08620	ENOG4107TDF	Formate hydrogenlyase subunit 4
C4901_08665	ENOG4107QJR	hflk protein
C4901_08675	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
C4901_08680	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
C4901_08690	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
C4901_08695	ENOG4105C2N	RNA methyltransferase TrmH family group 3
C4901_08700	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
C4901_08715	ENOG4105CDU	Replicative dna helicase
C4901_08720	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
C4901_08725	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
C4901_08750	ENOG4105CHR	reductase
C4901_08760	ENOG4105D63	family UPF0324
C4901_08765	ENOG4105S64	Formate nitrite transporter
C4901_08770	ENOG4105DIA	mandelate racemase muconate lactonizing
C4901_08785	ENOG4105C87	Aminotransferase class I and II
C4901_08790	ENOG4108UHJ	MAF-like protein
C4901_08795	ENOG4107QSA	Oxaloacetate decarboxylase
C4901_08800	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
C4901_08815	ENOG4105VGS	50s ribosomal protein l32
C4901_08820	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
C4901_08825	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
C4901_08830	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
C4901_08835	ENOG4105CHR	reductase
C4901_08840	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
C4901_08845	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
C4901_08855	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
C4901_08860	ENOG4105HHA	aminodeoxychorismate lyase
C4901_08865	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
C4901_08870	ENOG4107QRG	dna polymerase iii
C4901_08880	ENOG4105F8V	Hydrolase, tatD family
C4901_08915	ENOG4107QN2	dihydrolipoyl dehydrogenase
C4901_08930	ENOG4108UXE	Protein tyrosine phosphatase
C4901_08935	ENOG4105JAB	phenazine biosynthesis protein, phzf family
C4901_08965	ENOG4105DKP	glycosyl transferase, family 9
C4901_08970	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
C4901_08975	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
C4901_08980	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
C4901_08985	ENOG4107QWW	Cell wall formation (By similarity)
C4901_09000	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
C4901_09010	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
C4901_09215	ENOG4107QTH	restriction modification system DNA specificity domain
C4901_09405	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
C4901_09410	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
C4901_09415	ENOG4105E50	uracil-dna glycosylase
C4901_09420	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
C4901_09425	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
C4901_09430	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
C4901_09440	ENOG4105C6T	cysteine synthase
C4901_09445	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
C4901_09450	ENOG4105E3H	phosphoglycerate mutase
C4901_09460	ENOG4105D6E	homoserine dehydrogenase
C4901_09465	ENOG4105CHM	Aminotransferase
C4901_09475	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
C4901_09480	ENOG4108K5P	(LipO)protein
C4901_09485	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
C4901_09490	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
C4901_09495	ENOG4105D07	Signal peptide peptidase, SppA
C4901_09505	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
C4901_09510	ENOG4105EI2	Pseudouridine synthase
C4901_09525	ENOG4105KJF	protein tyrosine phosphatase
C4901_09530	ENOG4105KJF	protein tyrosine phosphatase
C4901_09540	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
C4901_09545	ENOG4105W49	UPF0434 protein
C4901_09550	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
C4901_09560	ENOG4105BZ1	(ABC) transporter
C4901_09575	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
C4901_09580	ENOG4105D60	lipoprotein releasing system transmembrane protein
C4901_09590	ENOG4105DFA	alanine racemase domain protein
C4901_09605	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
C4901_09610	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
C4901_09615	ENOG4105TV9	FHA Domain-Containing protein
C4901_09630	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
C4901_09635	ENOG4105E0F	Histidine kinase
C4901_09645	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
C4901_09665	ENOG4105D7V	transposase
C4901_09670	ENOG41089UC	methyltransferase, type 11
C4901_09675	ENOG4105ERH	Fumarylacetoacetate hydrolase
C4901_09680	ENOG4105DB1	molybdopterin oxidoreductase
C4901_09685	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
C4901_09690	ENOG4108KDI	dmso reductase anchor subunit
C4901_09695	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
C4901_09700	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
C4901_09705	ENOG4105M00	molybdopterin converting factor, subunit 1
C4901_09710	ENOG4108ZAF	Molybdopterin
C4901_09715	ENOG4105C5H	ABC transporter
C4901_09730	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
C4901_09760	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
C4901_09815	ENOG4105D29	Helix-turn-helix type 11 domain protein
C4901_09825	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
C4901_09870	ENOG4105CW7	secretion protein, HlyD family
C4901_09895	ENOG4105C59	p-type ATPase
C4901_09905	ENOG4108Z6Z	Transcriptional regulator
C4901_09910	ENOG4108KHN	disulfide isomerase, thiol-disulfide oxidase
C4901_09930	ENOG4105EHV	domain protein
C4901_09940	ENOG4105E27	serine threonine protein kinase
C4901_09945	ENOG4105ED1	spovr family
C4901_09950	ENOG4106AKX	UPF0229 protein
C4901_09955	ENOG4105CYN	Serine protein kinase
C4901_09965	ENOG4105EU0	Major facilitator Superfamily
C4901_09990	ENOG4108Q5Y	Membrane
C4901_10015	ENOG4105EUB	pirin domain protein
C4901_10040	ENOG4105EVH	UPF0753 protein
C4901_10050	ENOG4105D65	subunit l
C4901_10075	ENOG4108UQY	Iron-storage protein
C4901_10080	ENOG4105KNY	Microcompartments protein
C4901_10085	ENOG4105KNY	Microcompartments protein
C4901_10090	ENOG4105KNY	Microcompartments protein
C4901_10115	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
C4901_10120	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
C4901_10150	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
C4901_10155	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
C4901_10160	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
C4901_10165	ENOG4105CRK	lysyL-tRNA synthetase
C4901_10190	ENOG4105C9X	ppx gppa phosphatase
C4901_10275	ENOG4105D94	Major Facilitator Superfamily
C4901_10300	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
C4901_10305	ENOG410681N	tpr repeat protein
C4901_10310	ENOG4105E33	succinate dehydrogenase
C4901_10330	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
C4901_10335	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
C4901_10340	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
C4901_10345	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
C4901_10350	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
C4901_10355	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
C4901_10360	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
C4901_10365	ENOG4105C0B	DNA polymerase III (alpha subunit)
C4901_10370	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
C4901_10375	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C4901_10380	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
C4901_10385	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
C4901_10400	ENOG4105DZP	Membrane-associated zinc metalloprotease
C4901_10405	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
C4901_10410	ENOG4105KNE	Phosphatidate cytidylyltransferase
C4901_10415	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
C4901_10420	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
C4901_10425	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
C4901_10430	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
C4901_10435	ENOG4105CE9	30S ribosomal protein S2
C4901_10440	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
C4901_10510	ENOG4105CUB	amino acid
C4901_10515	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
C4901_10520	ENOG4108097	ATP-binding protein
C4901_10525	ENOG4105K8N	protein family UPF0079, ATPase
C4901_10530	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
C4901_10535	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
C4901_10540	ENOG41090A4	Pterin carbinolamine dehydratase
C4901_10545	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
C4901_10550	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
C4901_10585	ENOG4105VDW	Csbd family
C4901_10610	ENOG4108ZXC	Two component transcriptional regulator, luxr family
C4901_10640	ENOG4105GR3	Histidine kinase
C4901_10650	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
C4901_10655	ENOG4108Z6B	deaminase
C4901_10665	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
C4901_10695	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
C4901_10715	ENOG4105Z4T	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
C4901_10725	ENOG41090Y2	cytochrome C
C4901_10730	ENOG41090Y2	cytochrome C
C4901_10740	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
C4901_10765	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
C4901_10770	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
C4901_10780	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
C4901_10780	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
C4901_10785	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
C4901_10800	ENOG4105CUT	histidyl-tRNA synthetase
C4901_10805	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
C4901_10820	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
C4901_10825	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
C4901_10830	ENOG4105WVQ	Fe-S assembly protein IscX
C4901_10835	ENOG4108ZIT	Ferredoxin, 2FE-2S
C4901_10840	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
C4901_10845	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
C4901_10850	ENOG4108Z4V	iron-sulfur cluster assembly
C4901_10855	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
C4901_10860	ENOG4105C3J	Cysteine desulfurase
C4901_10865	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
C4901_10875	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
C4901_10880	ENOG4105ECY	inositol monophosphatase
C4901_10890	ENOG4108Z4U	Ferredoxin
C4901_10895	ENOG4105PBF	Anti-RNA polymerase sigma 70 factor
C4901_10900	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4901_10905	ENOG4105CRE	cytochrome C
C4901_10910	ENOG4108JU6	CBS domain protein
C4901_10915	ENOG4105C98	muts2 protein
C4901_10920	ENOG41072GX	Peptidase M22 Glycoprotease
C4901_10930	ENOG4105CPC	Aldo Keto reductase
C4901_10965	ENOG4105D85	methylase
C4901_10970	ENOG4105F6A	helicase
C4901_10975	ENOG4105ECI	YeeC-like protein
C4901_11050	ENOG4105WJ3	XRE family Transcriptional regulator
C4901_11055	ENOG4105RT5	Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation
C4901_11085	ENOG4105EKQ	RNA-directed DNA polymerase
C4901_11205	ENOG4105YAJ	CopG Arc MetJ
C4901_11275	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
C4901_11280	ENOG4105CFH	Aspartokinase
C4901_11285	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
C4901_11290	ENOG4105Y3E	Modulates RecA activity (By similarity)
C4901_11295	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
C4901_11305	ENOG4108ZAI	phosphatidylglycerophosphatase a
C4901_11310	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
C4901_11315	ENOG4107YIM	Involved in the transcription termination process (By similarity)
C4901_11320	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
C4901_11325	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
C4901_11330	ENOG4105D9P	serine threonine protein kinase
C4901_11345	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
C4901_11350	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
C4901_11355	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
C4901_11360	ENOG4105W3S	hemerythrin-like, metal-binding protein
C4901_11370	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
C4901_11375	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
C4901_11385	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
C4901_11395	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
C4901_11455	ENOG4105F6A	helicase
C4901_11460	ENOG4105ECI	YeeC-like protein
C4901_11630	ENOG4105BZU	Histidine kinase
C4901_11710	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
C4901_11715	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
C4901_11720	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
C4901_11725	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
C4901_11735	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C4901_11740	ENOG4105DJ0	Poly(A) Polymerase
C4901_11750	ENOG4105K63	Thioredoxin
C4901_11780	ENOG4107T8Q	Glycosyl transferase (Group 1
C4901_11790	ENOG4105CKK	Glycosyl transferase, family 2
C4901_11795	ENOG4107RA4	Glycosyl transferase (Group 1
C4901_11800	ENOG4108UW5	maltose o-acetyltransferase
C4901_11815	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
C4901_11825	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
C4901_11830	ENOG4105CEY	Amp-dependent synthetase and ligase
C4901_11835	ENOG4105CAQ	asparagine synthetase
C4901_11875	ENOG4105D1H	recombination factor protein RarA
C4901_11880	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
C4901_11885	ENOG4105CNU	cell division protein FtsK
C4901_11890	ENOG4105DCF	alanine dehydrogenase
C4901_11895	ENOG4105C3M	thioredoxin reductase
C4901_11905	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
C4901_11910	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
C4901_11920	ENOG4108JA2	transcriptioN-repair coupling factor
C4901_11930	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
C4901_11940	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
C4901_11945	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
C4901_11955	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
C4901_11965	ENOG4105EMU	Dehydrogenase
C4901_11975	ENOG4105DUM	transcriptional regulator, lysR family
C4901_11980	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
C4901_11990	ENOG4105FAE	von Willebrand factor, type A
C4901_12000	ENOG4105ESV	Glycosyl transferase, family 4
C4901_12015	ENOG4105BZ1	(ABC) transporter
C4901_12025	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
C4901_12030	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
C4901_12035	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
C4901_12040	ENOG4105CFV	Tetratricopeptide repeat protein
C4901_12050	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
C4901_12055	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
C4901_12060	ENOG4105CAT	Cytidine monophosphate kinase
C4901_12065	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
C4901_12075	ENOG4105CIH	Imidazole acetol-phosphate transaminase
C4901_12080	ENOG4105CQC	Prephenate dehydratase
C4901_12090	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
C4901_12095	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
C4901_12130	ENOG4108YXQ	IS66 Orf2 family protein
C4901_12200	ENOG4105CQS	hydrogenase expression formation protein HypD
C4901_12205	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
C4901_12215	ENOG4107RSS	Hydrogenase accessory protein HypB
C4901_12220	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
C4901_12240	ENOG4105X9Y	Hydrogenase assembly chaperone hypC hupF
C4901_12250	ENOG4105X7T	Ni Fe-hydrogenase, b-type cytochrome subunit
C4901_12260	ENOG4105E3S	small subunit
C4901_12275	ENOG4105DPX	Hydrogenase, large subunit
C4901_12280	ENOG4105E3S	small subunit
C4901_12300	ENOG4105C54	Major Facilitator superfamily
C4901_12320	ENOG4105EKE	dihydroorotase
C4901_12325	ENOG4105C4W	S-formylglutathione hydrolase
C4901_12330	ENOG4107QPD	alcohol dehydrogenase
C4901_12380	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
C4901_12400	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
C4901_12405	ENOG4106F1P	AAA ATPase, central domain protein
C4901_12410	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
C4901_12415	ENOG4105C7K	acetolactate synthase
C4901_12435	ENOG4105E0X	reductase
C4901_12455	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
C4901_12465	ENOG4105W1Y	Transcriptional regulator
C4901_12475	ENOG4107QX9	Thiol disulfide interChange protein
C4901_12480	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
C4901_12490	ENOG41060IM	Heme exporter protein
C4901_12495	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
C4901_12500	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
C4901_12510	ENOG4105KWW	Biogenesis protein
C4901_12515	ENOG4105DA4	cytochrome c-type biogenesis protein
C4901_12530	ENOG4108M8S	permease YjgP YjgQ family protein
C4901_12535	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
C4901_12555	ENOG4105WMR	Protein CrcB homolog
C4901_12565	ENOG4105WMR	Protein CrcB homolog
C4901_12570	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
C4901_12575	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
C4901_12635	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
C4901_12640	ENOG41082IR	Excinuclease ABC C subunit domain protein
C4901_12650	ENOG4105C0B	DNA polymerase III (alpha subunit)
C4901_12690	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
C4901_12695	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
C4901_12705	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
C4901_12710	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
C4901_12715	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
C4901_12720	ENOG4108ZP8	Acetolactate synthase small subunit
C4901_12725	ENOG4105C7K	acetolactate synthase
C4901_12750	ENOG4105C8N	cysteinyl-tRNA synthetase
C4901_12755	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
C4901_12760	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
C4901_12765	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
C4901_12775	ENOG4105C28	cystathionine
C4901_12780	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
C4901_12795	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
C4901_12800	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
C4901_12805	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
C4901_12810	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
C4901_12815	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
C4901_12830	ENOG4105DUM	transcriptional regulator, lysR family
C4901_12840	ENOG4105CZX	twitching motility protein
C4901_12880	ENOG4105DGU	Histone deacetylase
C4901_12925	ENOG4107QZT	geranylgeranyl reductase
C4901_12930	ENOG4105DF9	Lipoate-protein, ligase
C4901_12940	ENOG4105PHD	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
C4901_12950	ENOG4108UR0	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
C4901_12955	ENOG41086B8	CoB-CoM heterodisulfide reductase
C4901_12985	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
C4901_12990	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
C4901_12995	ENOG41082J7	Rhodanese domain protein
C4901_13030	ENOG41088H4	Diheme cytochrome SoxA (Sulfur oxidation)
C4901_13040	ENOG4105BZU	Histidine kinase
C4901_13065	ENOG41081FY	multiple antibiotic resistance (MarC)-related
C4901_13070	ENOG4107XID	2'-5' rna ligase
C4901_13080	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4901_13095	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
C4901_13135	ENOG4105GVR	general secretion pathway protein D
C4901_13150	ENOG4107QHF	type ii secretion system protein e
C4901_13165	ENOG4108YXQ	IS66 Orf2 family protein
C4901_13175	ENOG4107QHF	type ii secretion system protein e
C4901_13180	ENOG4105D7Q	type ii secretion system
C4901_13185	ENOG4108VAU	general secretion pathway protein G
C4901_13210	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
C4901_13220	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
C4901_13240	ENOG4105BZU	Histidine kinase
C4901_13275	ENOG4105BZU	Histidine kinase
C4901_13305	ENOG4105M8F	Biopolymer transport protein exbD tolR
C4901_13325	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
C4901_13330	ENOG4105CWN	amidohydrolase
C4901_13360	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
C4901_13365	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
C4901_13370	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
C4901_13410	ENOG4108I5U	Uridine phosphorylase
C4901_13415	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
C4901_13420	ENOG4105KG3	cytidine deaminase
C4901_13445	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
C4901_13450	ENOG4108R86	Transcriptional regulator
C4901_13455	ENOG4107RDB	Major Facilitator
C4901_13460	ENOG4105BZU	Histidine kinase
C4901_13470	ENOG4105BZU	Histidine kinase
C4901_13485	ENOG4105K2Z	endo-1,4-d-glucanase (EC 3.2.1.4)
C4901_13500	ENOG4107QZ7	Cellulose synthase catalytic subunit
C4901_13510	ENOG4108YXQ	IS66 Orf2 family protein
C4901_13615	ENOG4108YXQ	IS66 Orf2 family protein
C4901_13670	ENOG4108YXQ	IS66 Orf2 family protein
C4901_13765	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
C4901_13770	ENOG4107VRB	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
C4901_13780	ENOG4105KCK	Peptidoglycan-associated lipoprotein
C4901_13785	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
C4901_13795	ENOG4105M8F	Biopolymer transport protein exbD tolR
C4901_13800	ENOG4105E02	MotA TolQ exbB proton channel
C4901_13805	ENOG4107YD3	Thioesterase
C4901_13810	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
C4901_13820	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
C4901_13825	ENOG4105CDY	transcriptional regulatory protein
C4901_13840	ENOG4105C9M	aspartyl-trna synthetase
C4901_13870	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
C4901_13885	ENOG4105CZX	twitching motility protein
C4901_13890	ENOG4105BZW	Glycerate kinase
C4901_13905	ENOG4105C1G	acyl-Coa dehydrogenase
C4901_13910	ENOG4105NQN	cytochrome C
C4901_13925	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
C4901_13965	ENOG4108UUM	single-stranded DNA-binding protein
C4901_13970	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
C4901_13985	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
C4901_13990	ENOG4105XA0	heptosyltransferase ii
C4901_13995	ENOG4108ZT0	50S ribosomal protein l17
C4901_14000	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C4901_14005	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
C4901_14010	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
C4901_14015	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4901_14020	ENOG41067V7	50S ribosomal protein L36
C4901_14025	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
C4901_14030	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
C4901_14035	ENOG4105VPB	50S ribosomal protein L30
C4901_14040	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
C4901_14045	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
C4901_14050	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
C4901_14055	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
C4901_14065	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4901_14070	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
C4901_14075	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
C4901_14080	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
C4901_14085	ENOG41083MP	50s ribosomal protein l29
C4901_14090	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
C4901_14095	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
C4901_14100	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
C4901_14105	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
C4901_14110	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4901_14115	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
C4901_14120	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
C4901_14125	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
C4901_14130	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
C4901_14135	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
C4901_14140	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
C4901_14145	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
C4901_14150	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
C4901_14155	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C4901_14160	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
C4901_14165	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
C4901_14170	ENOG4108VZM	50s ribosomal protein L10
C4901_14175	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
C4901_14180	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
C4901_14185	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
C4901_14190	ENOG4105PM1	preprotein translocase subunit SecE
C4901_14205	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
C4901_14210	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
C4901_14230	ENOG4108I0Z	Aconitate hydratase
C4901_14250	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
C4901_14255	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
C4901_14285	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
C4901_14290	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
C4901_14295	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
C4901_14310	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
C4901_14320	ENOG4105BZU	Histidine kinase
C4901_14355	ENOG4105NZG	Ferredoxin
C4901_14360	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
C4901_14365	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
C4901_14375	ENOG4108UKZ	OsmC family
C4901_14380	ENOG4105DK0	Indole-3-glycerol phosphate synthase
C4901_14385	ENOG4107QYG	anthranilate phosphoribosyltransferase
C4901_14390	ENOG4105DDQ	anthranilate synthase
C4901_14395	ENOG4105CRQ	synthase (Component I)
C4901_14400	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
C4901_14415	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
C4901_14430	ENOG4105E02	MotA TolQ exbB proton channel
C4901_14440	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
C4901_14460	ENOG4105D2N	Aldolase
C4901_14465	ENOG4105CA9	Pyruvate kinase
C4901_14470	ENOG4105BZA	Phosphoglycerate kinase
C4901_14475	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
C4901_14480	ENOG4105CV1	Transketolase (EC 2.2.1.1)
C4901_14485	ENOG4105DBI	uridine monophosphokinase
C4901_14515	ENOG4105CBS	Chea signal transduction histidine kinase
C4901_14520	ENOG4105C8Q	Methyl-accepting chemotaxis
C4901_14525	ENOG4108ZGA	chew protein
C4901_14530	ENOG4105M3Z	response regulator
C4901_14535	ENOG4108UNF	response regulator
C4901_14545	ENOG4105D7Z	glutathione synthase
C4901_14555	ENOG4108UJU	UPF0301 protein
C4901_14560	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
C4901_14565	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
C4901_14570	ENOG4105CXT	aspartate transcarbamylase
C4901_14575	ENOG4105CD3	dihydroorotase
C4901_14590	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
C4901_14595	ENOG4105CZX	twitching motility protein
C4901_14600	ENOG4105CZX	twitching motility protein
C4901_14605	ENOG4105II7	pyrroline-5-carboxylate reductase
C4901_14610	ENOG4108VIA	integral membrane protein
C4901_14615	ENOG4107QX9	Thiol disulfide interChange protein
C4901_14625	ENOG41080RH	Thioredoxin
C4901_14630	ENOG4105DWV	Homoserine O-trans-acetylase
C4901_14635	ENOG4105DWV	Homoserine O-trans-acetylase
C4901_14640	ENOG4108E7F	Transporter
C4901_14645	ENOG4105CGK	Exodeoxyribonuclease III
C4901_14655	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
C4901_14670	ENOG4107RIQ	Sulfate adenylate transferase
C4901_14690	ENOG4105BZU	Histidine kinase
C4901_14695	ENOG4105CA0	peroxidase
C4901_14700	ENOG4105PS4	nifq family
C4901_14705	ENOG4105WCA	Ferredoxin
C4901_14715	ENOG4108VQE	nitrogen fixation protein
C4901_14720	ENOG4108UR2	Nitrogen fixation protein NifX
C4901_14725	ENOG4105DK8	Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN
C4901_14730	ENOG4105D0B	Nitrogenase protein alpha chain
C4901_14735	ENOG4105U82	Ferredoxin
C4901_14740	ENOG4105CY9	nitrogenase molybdenum-iron protein beta chain
C4901_14745	ENOG4105D0B	Nitrogenase protein alpha chain
C4901_14750	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
C4901_14765	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
C4901_14780	ENOG4105C3J	Cysteine desulfurase
C4901_14795	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
C4901_14800	ENOG4105CGC	Nitrogenase cofactor biosynthesis protein NifB
C4901_14810	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
C4901_14815	ENOG4105BZU	Histidine kinase
C4901_14820	ENOG41090P5	ferredoxin-like protein
C4901_14830	ENOG4105C10	Electron transfer flavoprotein
C4901_14835	ENOG4105BZJ	Electron transfer flavoprotein
C4901_14845	ENOG410605C	May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity)
C4901_14850	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
C4901_14855	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
C4901_14860	ENOG4108JUA	Transcriptional regulator
C4901_14880	ENOG4105BZU	Histidine kinase
C4901_14915	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
C4901_14925	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
C4901_14930	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
C4901_14935	ENOG4105C0D	helicase
C4901_14940	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
C4901_14945	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
C4901_14950	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
C4901_14955	ENOG4105C01	Dihydroxy-acid dehydratase
C4901_14960	ENOG4105EKE	dihydroorotase
C4901_14970	ENOG4105EVH	UPF0753 protein
C4901_14975	ENOG4105D2N	Aldolase
C4901_14980	ENOG4105DUM	transcriptional regulator, lysR family
C4901_15010	ENOG4105BZU	Histidine kinase
C4901_15030	ENOG4105EVH	UPF0753 protein
C4901_15035	ENOG4105D65	subunit l
C4901_15060	ENOG4108IUE	nitrate reductase beta subunit
C4901_15065	ENOG4105R3A	Nitrate reductase
C4901_15075	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
C4901_15120	ENOG4105VT3	DNA binding domain protein, excisionase family
C4901_15180	ENOG4105DSQ	Nitric oxide reductase
C4901_15275	ENOG4105EQR	Transposase IS116 IS110 IS902
C4901_15305	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
C4901_15470	ENOG4105X0D	Fimbrial protein
C4901_15505	ENOG4105D3R	alkyl hydroperoxide reductase
C4901_15510	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
C4901_15515	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
C4901_15540	ENOG4107R11	Transcriptional regulator
C4901_15565	ENOG4105EIX	cytochrome c1
C4901_15575	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
C4901_15595	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
C4901_15600	ENOG41090Y2	cytochrome C
C4901_15615	ENOG4105BZU	Histidine kinase
C4901_15655	ENOG4105C3U	ABC transporter
C4901_15665	ENOG4105C4R	Atp-dependent dna helicase
C4901_15675	ENOG4105C57	major facilitator superfamily
C4901_15680	ENOG4108ZHR	arsR family transcriptional regulator
C4901_15765	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
C4901_15775	ENOG4105VCC	30S ribosomal protein S21
C4901_15785	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
C4901_15790	ENOG4105KRF	dihydroneopterin aldolase
C4901_15825	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
C4901_15835	ENOG4105FAE	von Willebrand factor, type A
C4901_15845	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
C4901_15865	ENOG4107SC1	transglycosylase
C4901_15880	ENOG4105DR4	Methyltransferase
C4901_15885	ENOG4105C7Z	Conserved Protein
C4901_15890	ENOG41082J7	Rhodanese domain protein
C4901_15910	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4901_15915	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
C4901_15920	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4901_15930	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
C4901_15955	ENOG4107R8N	Glycosyl transferase, family 2
C4901_15970	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
C4901_15995	ENOG4105CGK	Exodeoxyribonuclease III
C4901_16005	ENOG4105DGW	oligopeptidase A
C4901_16010	ENOG4105E2X	shikimate dehydrogenase
C4901_16020	ENOG4108U78	Glutathione S-transferase
C4901_16025	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
C4901_16040	ENOG4105ESI	atpase involved in dna repair
C4901_16045	ENOG4105CB5	ATP-dependent DNA helicase recG
C4901_16065	ENOG4105CB5	ATP-dependent DNA helicase recG
C4901_16070	ENOG4105KME	endoribonuclease L-psp
C4901_16075	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
C4901_16080	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
C4901_16085	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
C4901_16090	ENOG4105D9P	serine threonine protein kinase
C4901_16095	ENOG4108ZF3	Phosphatase
C4901_16100	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
C4901_16105	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
C4901_16110	ENOG4105CSA	Coproporphyrinogen iii oxidase
C4901_16115	ENOG4108YXA	Membrane
C4901_16135	ENOG4105CPI	Metal Dependent Phosphohydrolase
C4901_16185	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
C4901_16190	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
C4901_16195	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
C4901_16200	ENOG4105CQM	Urea amidohydrolase subunit alpha
C4901_16205	ENOG4105KI2	Urea amidohydrolase subunit beta
C4901_16210	ENOG4108YZ9	Urea amidohydrolase subunit gamma
C4901_16215	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
C4901_16225	ENOG4108IJF	Heavy metal efflux pump, CzcA
C4901_16255	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
C4901_16265	ENOG4105C25	Primosomal protein n'
C4901_16270	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
C4901_16275	ENOG4105BZ8	glutamate synthase
C4901_16280	ENOG4105CBC	glutamate synthase
C4901_16285	ENOG4105D49	3-dehydroquinate synthase
C4901_16290	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
C4901_16295	ENOG4105E4G	Type IV pilus
C4901_16340	ENOG4108JQC	penicillin-binding protein 1A
C4901_16350	ENOG4105C75	arginyL-tRNA synthetase
C4901_16360	ENOG4105KHC	sulfurtransferase
C4901_16365	ENOG4108V7B	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)
C4901_16370	ENOG4105D7T	ABC transporter
C4901_16385	ENOG4108JUA	Transcriptional regulator
C4901_16400	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
C4901_16410	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
C4901_16415	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
C4901_16450	ENOG4107QX8	SPFH domain, Band 7 family protein
C4901_16470	ENOG4105VFE	sira family
C4901_16475	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
C4901_16490	ENOG41082F9	transcriptional regulator
C4901_16505	ENOG4105BZS	acriflavin resistance protein
C4901_16510	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
C4901_16520	ENOG4108K3A	Glutathione S-transferase
C4901_16530	ENOG4105E0C	molybdate abc transporter
C4901_16535	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
C4901_16540	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
C4901_16545	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
C4901_16550	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
C4901_16560	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
C4901_16595	ENOG4105BZU	Histidine kinase
C4901_16600	ENOG4108YZA	Nitrogen regulatory protein pii
C4901_16605	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
C4901_16610	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
C4901_16695	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
C4901_16720	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
C4901_16725	ENOG4105BZU	Histidine kinase
C4901_16755	ENOG4105BZP	glycoside hydrolase 15-related
C4901_16760	ENOG4105VFB	Binds the 23S rRNA (By similarity)
C4901_16765	ENOG4105C6K	Malic enzyme
C4901_16770	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
C4901_16775	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
C4901_16790	ENOG4108IQE	Amp-dependent synthetase and ligase
C4901_16795	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
C4901_16805	ENOG4105C1G	acyl-Coa dehydrogenase
C4901_16825	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
C4901_16855	ENOG4105C7K	acetolactate synthase
C4901_16870	ENOG4105DFU	Cell wall formation (By similarity)
C4901_16880	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
C4901_16885	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
C4901_16905	ENOG4105C2M	dna polymerase I
C4901_16915	ENOG4105CUV	Homoserine Kinase
C4901_16930	ENOG4105C4R	Atp-dependent dna helicase
C4901_16950	ENOG41087YS	Phage shock protein A
C4901_16975	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
C4901_16980	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
C4901_16985	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
C4901_16990	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
C4901_16995	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
C4901_17000	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
C4901_17005	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
C4901_17010	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
C4901_17015	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
C4901_17020	ENOG41081A3	ATP synthase f0, c subunit
C4901_17025	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
C4901_17040	ENOG4105FA0	parb-like partition protein
C4901_17045	ENOG4107QJE	Chromosome Partitioning Protein
C4901_17055	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
C4901_17090	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
C4901_17100	ENOG4105F8C	transglutaminase domain-containing protein
C4901_17105	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
C4901_17110	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
C4901_17115	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
C4901_17120	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
C4901_17125	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)