locus-tag	class	description
C4901_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4901_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4901_00025	COG0187	DNA topoisomerase II activity
C4901_00035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4901_00040	COG2022	thiamine diphosphate biosynthetic process
C4901_00110	COG1194	a g-specific adenine glycosylase
C4901_00115	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4901_00120	COG0412	Dienelactone hydrolase
C4901_00165	COG3008	intermembrane lipid transfer
C4901_00170	COG2995	paraquat-inducible protein a
C4901_00175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4901_00180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4901_00185	COG1845	cytochrome c oxidase, subunit III
C4901_00205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4901_00215	COG1011	Hydrolase
C4901_00245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4901_00250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4901_00265	COG1519	Transferase
C4901_00270	COG0859	PFAM glycosyl transferase family 9
C4901_00330	COG0438	transferase activity, transferring glycosyl groups
C4901_00335	COG0859	PFAM glycosyl transferase family 9
C4901_00390	COG0572	uridine kinase
C4901_00395	COG0859	PFAM glycosyl transferase family 9
C4901_00415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C4901_00430	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C4901_00435	COG1850	ribulose-bisphosphate carboxylase activity
C4901_00440	COG0235	Class ii aldolase
C4901_00495	COG0408	coproporphyrinogen oxidase activity
C4901_00500	COG0151	Belongs to the GarS family
C4901_00505	COG0138	bifunctional purine biosynthesis protein purh
C4901_00510	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C4901_00525	COG2264	protein methyltransferase activity
C4901_00530	COG0439	Biotin carboxylase
C4901_00535	COG0511	ligase activity, forming carbon-carbon bonds
C4901_00540	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4901_00545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4901_00550	COG4232	protein-disulfide reductase activity
C4901_00555	COG1324	tolerance protein
C4901_00565	COG3030	protein affecting phage T7 exclusion by the F plasmid
C4901_00570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4901_00575	COG0459	protein refolding
C4901_00585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4901_00585	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C4901_00590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4901_00600	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_00675	COG0352	thiamine-phosphate diphosphorylase activity
C4901_00680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4901_00690	COG3706	GGDEF domain
C4901_00710	COG2967	ApaG domain
C4901_00715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4901_00725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4901_00765	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4901_00770	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4901_00775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4901_00780	COG0037	tRNA processing
C4901_00785	COG1560	Kdo2-lipid A biosynthetic process
C4901_00795	COG1560	Kdo2-lipid A biosynthetic process
C4901_00810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4901_00815	COG0242	peptide deformylase activity
C4901_00825	COG2922	Belongs to the Smg family
C4901_00835	COG4232	protein-disulfide reductase activity
C4901_00845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4901_00850	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4901_00860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4901_00870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4901_00875	COG4942	peptidase
C4901_00880	COG0793	Belongs to the peptidase S41A family
C4901_00895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4901_00910	COG2226	methyltransferase
C4901_00920	COG0745	RESPONSE REGULATOR receiver
C4901_00980	COG0493	'glutamate synthase
C4901_00980	COG0543	2 iron, 2 sulfur cluster binding
C4901_00995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4901_01010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4901_01015	COG0704	Plays a role in the regulation of phosphate uptake
C4901_01025	COG0563	adenylate kinase activity
C4901_01035	COG0205	6-phosphofructokinase activity
C4901_01045	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C4901_01065	COG2076	Multidrug Resistance protein
C4901_01070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4901_01090	COG0726	polysaccharide deacetylase
C4901_01095	COG1643	Atp-dependent helicase
C4901_01100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4901_01125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4901_01135	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4901_01140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4901_01145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4901_01150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4901_01165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4901_01185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4901_01190	COG0482	sulfurtransferase activity
C4901_01205	COG0174	glutamine synthetase
C4901_01280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4901_01280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4901_01290	COG1242	4 iron, 4 sulfur cluster binding
C4901_01345	COG2070	2-Nitropropane dioxygenase
C4901_01355	COG1272	protein, Hemolysin III
C4901_01380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4901_01385	COG0321	lipoyl(octanoyl) transferase activity
C4901_01410	COG2921	Belongs to the UPF0250 family
C4901_01425	COG0772	Belongs to the SEDS family
C4901_01430	COG0768	penicillin binding
C4901_01435	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C4901_01440	COG1792	Involved in formation and maintenance of cell shape
C4901_01445	COG1077	Cell shape determining protein MreB Mrl
C4901_01450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4901_01455	COG0154	amidase activity
C4901_01460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4901_01505	COG2226	methyltransferase
C4901_01555	COG2048	Heterodisulfide reductase, subunit B
C4901_01580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4901_01595	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C4901_01600	COG1914	H( )-stimulated, divalent metal cation uptake system
C4901_01605	COG3852	Histidine kinase
C4901_01610	COG2204	response regulator
C4901_01625	COG1127	ABC transporter
C4901_01630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4901_01635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4901_01640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4901_01645	COG0006	proline dipeptidase activity
C4901_01665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4901_01670	COG1692	metallophosphoesterase
C4901_01690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4901_01710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4901_01715	COG0604	alcohol dehydrogenase
C4901_01755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4901_01785	COG3267	Type II secretory pathway component ExeA
C4901_01785	COG3409	Peptidoglycan-binding domain 1 protein
C4901_01805	COG0156	8-amino-7-oxononanoate synthase activity
C4901_01815	COG2226	methyltransferase
C4901_01870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4901_01890	COG2177	Part of the ABC transporter FtsEX involved in
C4901_01895	COG2884	Cell division ATP-binding protein ftsE
C4901_01900	COG0552	protein localization to endoplasmic reticulum
C4901_01905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4901_01910	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4901_01915	COG0742	ribosomal rna small subunit methyltransferase
C4901_01930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4901_01950	COG1131	(ABC) transporter
C4901_01955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4901_01955	COG0543	2 iron, 2 sulfur cluster binding
C4901_02075	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C4901_02080	COG1518	maintenance of DNA repeat elements
C4901_02155	COG3071	HemY protein
C4901_02170	COG0181	hydroxymethylbilane synthase activity
C4901_02190	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4901_02200	COG0477	Major facilitator Superfamily
C4901_02205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4901_02210	COG0730	response to heat
C4901_02220	COG0165	Argininosuccinate lyase
C4901_02225	COG3275	phosphorelay sensor kinase activity
C4901_02245	COG1335	isochorismatase
C4901_02255	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4901_02280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4901_02290	COG1965	Belongs to the frataxin family
C4901_02305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4901_02315	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4901_02330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4901_02335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4901_02350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4901_02360	COG1309	transcriptional regulator
C4901_02380	COG2890	protein-(glutamine-N5) methyltransferase activity
C4901_02385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4901_02390	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4901_02405	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4901_02410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4901_02420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4901_02425	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4901_02430	COG0193	aminoacyl-tRNA hydrolase activity
C4901_02435	COG0012	GTP binding
C4901_02480	COG3093	addiction module antidote protein HigA
C4901_02515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4901_02535	COG1943	Transposase
C4901_02545	COG2308	Evidence 4 Homologs of previously reported genes of
C4901_02570	COG1993	acr, cog1993
C4901_02575	COG0651	ATP synthesis coupled electron transport
C4901_02580	COG3260	NADH ubiquinone oxidoreductase 20
C4901_02585	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4901_02585	COG0649	NAD binding
C4901_02590	COG0651	ATP synthesis coupled electron transport
C4901_02600	COG0650	Formate hydrogenlyase subunit 4
C4901_02620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4901_02645	COG3118	belongs to the thioredoxin family
C4901_02650	COG1295	ribonuclease BN
C4901_02655	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4901_02675	COG0545	Peptidyl-prolyl cis-trans isomerase
C4901_02690	COG0277	FAD linked oxidase domain protein
C4901_02695	COG0277	FAD linked oxidase domain protein
C4901_02700	COG0247	lactate metabolic process
C4901_02715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4901_02720	COG1702	phosphate starvation-inducible protein PhoH
C4901_02725	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4901_02730	COG4535	Mg2 and Co2 transporter CorC
C4901_02735	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4901_02810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4901_02830	COG0495	leucyl-tRNA aminoacylation
C4901_02835	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
C4901_02845	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4901_02850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4901_02860	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4901_02865	COG0424	maF-like protein
C4901_02870	COG1530	ribonuclease E activity
C4901_02880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4901_02885	COG0312	modulator of DNA gyrase
C4901_02890	COG0312	modulator of DNA gyrase
C4901_02900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4901_02960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4901_02965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4901_02975	COG1660	Displays ATPase and GTPase activities
C4901_02980	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C4901_02995	COG1137	ATPase activity
C4901_03010	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4901_03025	COG1131	(ABC) transporter
C4901_03085	COG1127	ABC transporter
C4901_03090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4901_03095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4901_03110	COG1131	(ABC) transporter
C4901_03115	COG0842	Transport permease protein
C4901_03120	COG0271	Belongs to the BolA IbaG family
C4901_03125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4901_03130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4901_03135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4901_03140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4901_03145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4901_03150	COG0131	Imidazoleglycerol-phosphate dehydratase
C4901_03155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4901_03160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4901_03165	COG0107	imidazoleglycerol-phosphate synthase activity
C4901_03175	COG0140	phosphoribosyl-ATP diphosphatase activity
C4901_03185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4901_03190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4901_03200	COG0477	Major facilitator Superfamily
C4901_03205	COG0438	transferase activity, transferring glycosyl groups
C4901_03215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4901_03220	COG0625	glutathione transferase activity
C4901_03250	COG0277	FAD linked oxidase domain protein
C4901_03255	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4901_03265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4901_03290	COG2863	cytochrome
C4901_03295	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_03305	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4901_03310	COG2857	Cytochrome c1
C4901_03315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4901_03320	COG0148	phosphopyruvate hydratase activity
C4901_03345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4901_03355	COG2001	Belongs to the MraZ family
C4901_03360	COG0275	rRNA processing
C4901_03375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4901_03380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4901_03385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4901_03390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4901_03395	COG0772	Belongs to the SEDS family
C4901_03400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4901_03405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4901_03410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4901_03415	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4901_03420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C4901_03430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4901_03435	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4901_03445	COG0739	heme binding
C4901_03450	COG0653	protein targeting
C4901_03455	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4901_03460	COG0494	nUDIX hydrolase
C4901_03545	COG2204	response regulator
C4901_03575	COG0039	L-malate dehydrogenase activity
C4901_03585	COG0237	dephospho-CoA kinase activity
C4901_03590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C4901_03600	COG1592	Rubrerythrin
C4901_03650	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4901_03655	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4901_03660	COG3547	Transposase (IS116 IS110 IS902 family)
C4901_03715	COG4584	PFAM Integrase catalytic
C4901_03720	COG3047	cAMP biosynthetic process
C4901_03720	COG2885	chlorophyll binding
C4901_03725	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4901_03730	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4901_03735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4901_03745	COG3852	Histidine kinase
C4901_03760	COG2201	protein-glutamate methylesterase activity
C4901_03765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4901_03770	COG0047	phosphoribosylformylglycinamidine synthase activity
C4901_03770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4901_03785	COG0509	glycine decarboxylation via glycine cleavage system
C4901_03815	COG5265	(ABC) transporter
C4901_03820	COG0488	(ABC) transporter
C4901_03830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4901_03835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4901_03840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4901_03845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4901_03850	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4901_03850	COG0022	dehydrogenase e1 component
C4901_03855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4901_03860	COG0137	argininosuccinate synthase activity
C4901_03865	COG3852	Histidine kinase
C4901_03890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4901_03905	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4901_03950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4901_03950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4901_03970	COG0717	Belongs to the dCTP deaminase family
C4901_04010	COG0756	dUTP diphosphatase activity
C4901_04015	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4901_04020	COG2003	Belongs to the UPF0758 family
C4901_04030	COG3383	formate dehydrogenase (NAD+) activity
C4901_04035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4901_04040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4901_04075	COG1595	DNA-templated transcription, initiation
C4901_04080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4901_04085	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4901_04090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4901_04095	COG0628	permease
C4901_04110	COG1027	Aspartate ammonia-lyase
C4901_04120	COG0500	methyltransferase
C4901_04150	COG2201	protein-glutamate methylesterase activity
C4901_04160	COG0477	Major facilitator Superfamily
C4901_04170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4901_04170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4901_04175	COG1902	pentaerythritol trinitrate reductase activity
C4901_04180	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C4901_04185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4901_04190	COG1509	lysine 2,3-aminomutase activity
C4901_04200	COG0450	alkyl hydroperoxide reductase
C4901_04205	COG1254	Belongs to the acylphosphatase family
C4901_04220	COG0442	prolyl-tRNA aminoacylation
C4901_04235	COG2433	Pfam Transposase IS66
C4901_04270	COG1940	carbohydrate kinase activity
C4901_04275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4901_04280	COG2814	Major facilitator Superfamily
C4901_04290	COG1566	PFAM secretion protein HlyD family protein
C4901_04300	COG1469	GTP cyclohydrolase I activity
C4901_04305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4901_04310	COG0142	geranyltranstransferase activity
C4901_04315	COG1722	exodeoxyribonuclease VII activity
C4901_04325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4901_04390	COG0656	L-ascorbic acid biosynthetic process
C4901_04395	COG0667	Aldo Keto reductase
C4901_04410	COG1064	alcohol dehydrogenase
C4901_04425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4901_04435	COG2867	negative regulation of translational initiation
C4901_04445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4901_04455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4901_04455	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4901_04460	COG0497	DNA recombination
C4901_04465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4901_04470	COG1420	regulation of RNA biosynthetic process
C4901_04475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4901_04480	COG0443	Heat shock 70 kDa protein
C4901_04485	COG0484	heat shock protein binding
C4901_04495	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4901_04500	COG0505	Belongs to the CarA family
C4901_04505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4901_04510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4901_04520	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4901_04525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4901_04530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4901_04535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4901_04540	COG0149	triose-phosphate isomerase activity
C4901_04555	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4901_04560	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4901_04565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4901_04570	COG0649	NAD binding
C4901_04575	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C4901_04585	COG1034	ATP synthesis coupled electron transport
C4901_04585	COG1034	ATP synthesis coupled electron transport
C4901_04590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4901_04595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4901_04605	COG0713	ATP synthesis coupled electron transport
C4901_04620	COG1007	ATP synthesis coupled electron transport
C4901_04655	COG0779	Required for maturation of 30S ribosomal subunits
C4901_04660	COG0195	Participates in both transcription termination and antitermination
C4901_04660	COG2251	uridine kinase activity
C4901_04665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4901_04670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4901_04680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4901_04685	COG1185	polyribonucleotide nucleotidyltransferase activity
C4901_04700	COG0429	hydrolase of the alpha beta-hydrolase fold
C4901_04705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4901_04710	COG0586	Pfam SNARE associated Golgi protein
C4901_04715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C4901_04720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4901_04725	COG0720	synthase
C4901_04730	COG0546	phosphoglycolate phosphatase activity
C4901_04735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4901_04740	COG0402	S-adenosylhomocysteine deaminase activity
C4901_04750	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4901_04755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4901_04760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4901_04765	COG1845	cytochrome c oxidase, subunit III
C4901_04785	COG0730	response to heat
C4901_04795	COG3387	PFAM Glycoside hydrolase 15-related
C4901_04850	COG3852	Histidine kinase
C4901_04910	COG2944	sequence-specific DNA binding
C4901_04915	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4901_04925	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C4901_04935	COG1064	alcohol dehydrogenase
C4901_04975	COG2165	general secretion pathway protein
C4901_05025	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4901_05030	COG0543	2 iron, 2 sulfur cluster binding
C4901_05030	COG0493	'glutamate synthase
C4901_05115	COG0142	geranyltranstransferase activity
C4901_05120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4901_05125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4901_05130	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4901_05135	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4901_05140	COG0268	Binds directly to 16S ribosomal RNA
C4901_05155	COG0196	riboflavin kinase activity
C4901_05160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4901_05170	COG1047	Peptidyl-prolyl cis-trans
C4901_05175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4901_05250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4901_05270	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C4901_05285	COG0330	HflC and HflK could
C4901_05320	COG3547	Transposase (IS116 IS110 IS902 family)
C4901_05335	COG1902	pentaerythritol trinitrate reductase activity
C4901_05340	COG0386	Belongs to the glutathione peroxidase family
C4901_05355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4901_05360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4901_05365	COG1215	transferase activity, transferring glycosyl groups
C4901_05375	COG2853	Lipoprotein
C4901_05380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4901_05395	COG3394	polysaccharide catabolic process
C4901_05415	COG1657	PFAM Prenyltransferase squalene oxidase
C4901_05465	COG0625	glutathione transferase activity
C4901_05475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4901_05480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4901_05485	COG1845	cytochrome c oxidase, subunit III
C4901_05500	COG2192	nodulation
C4901_05565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4901_05575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4901_05580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4901_05585	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4901_05590	COG0072	phenylalanine-tRNA ligase activity
C4901_05590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4901_05595	COG0776	regulation of translation
C4901_05610	COG0625	glutathione transferase activity
C4901_05620	COG0004	ammonium transporteR
C4901_05625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4901_05690	COG2199	diguanylate cyclase activity
C4901_05690	COG2200	EAL domain
C4901_05735	COG0859	PFAM glycosyl transferase family 9
C4901_05760	COG0326	Molecular chaperone. Has ATPase activity
C4901_05765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4901_05775	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4901_05780	COG0740	serine-type endopeptidase activity
C4901_05790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4901_05805	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4901_05815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4901_05825	COG0741	lytic transglycosylase activity
C4901_05825	COG1388	LysM domain
C4901_05830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4901_05835	COG2226	methyltransferase
C4901_05840	COG0328	RNA-DNA hybrid ribonuclease activity
C4901_05845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4901_05870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4901_05870	COG1648	precorrin-2 dehydrogenase activity
C4901_05875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4901_05880	COG2146	nitrite reductase [NAD(P)H] activity
C4901_05885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4901_05890	COG0670	Belongs to the BI1 family
C4901_05900	COG0297	glycogen (starch) synthase activity
C4901_05915	COG0837	glucose binding
C4901_05920	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4901_05925	COG0166	Belongs to the GPI family
C4901_05930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4901_05970	COG2204	response regulator
C4901_05975	COG0058	SHG alpha-glucan phosphorylase activity
C4901_05980	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4901_06010	COG3284	Transcriptional regulator
C4901_06015	COG2204	response regulator
C4901_06035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4901_06040	COG0366	Alpha amylase catalytic
C4901_06060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4901_06120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4901_06130	COG1845	cytochrome c oxidase, subunit III
C4901_06155	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4901_06165	COG2084	Dehydrogenase
C4901_06170	COG3158	transport of potassium into the cell
C4901_06190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4901_06190	COG0574	Belongs to the PEP-utilizing enzyme family
C4901_06220	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4901_06225	COG3706	GGDEF domain
C4901_06225	COG0745	RESPONSE REGULATOR receiver
C4901_06230	COG2198	Histidine kinase
C4901_06230	COG5002	protein histidine kinase activity
C4901_06230	COG0784	Response regulator, receiver
C4901_06305	COG3546	catalase activity
C4901_06310	COG1914	H( )-stimulated, divalent metal cation uptake system
C4901_06350	COG0778	Nitroreductase
C4901_06365	COG1733	regulation of RNA biosynthetic process
C4901_06405	COG3012	SEC-C Motif Domain Protein
C4901_06410	COG0515	serine threonine protein kinase
C4901_06415	COG0531	amino acid
C4901_06420	COG0069	glutamate synthase activity
C4901_06430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C4901_06435	COG0174	glutamine synthetase
C4901_06445	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4901_06445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4901_06535	COG3609	addiction module antidote protein, CC2985 family
C4901_06570	COG1216	Glycosyl transferase, family 2
C4901_06570	COG0438	transferase activity, transferring glycosyl groups
C4901_06575	COG3550	peptidyl-serine autophosphorylation
C4901_06590	COG1396	sequence-specific DNA binding
C4901_06675	COG0438	transferase activity, transferring glycosyl groups
C4901_06680	COG0438	transferase activity, transferring glycosyl groups
C4901_06690	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C4901_06700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4901_06705	COG0438	transferase activity, transferring glycosyl groups
C4901_06765	COG2221	Nitrite and sulphite reductase 4Fe-4S
C4901_06770	COG2221	Nitrite and sulphite reductase 4Fe-4S
C4901_06775	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C4901_06780	COG2923	Belongs to the DsrF TusC family
C4901_06790	COG2920	part of a sulfur-relay system
C4901_06825	COG1797	cobyrinic acid a,c-diamide synthase activity
C4901_06830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4901_06840	COG2197	response regulator
C4901_06845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4901_06865	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4901_06875	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C4901_06900	COG1648	precorrin-2 dehydrogenase activity
C4901_06900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4901_06910	COG2003	Belongs to the UPF0758 family
C4901_06955	COG4942	peptidase
C4901_06975	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4901_06980	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4901_06995	COG1403	HNH endonuclease
C4901_07000	COG1278	Cold shock
C4901_07005	COG2943	transferase activity, transferring hexosyl groups
C4901_07005	COG3416	Protein conserved in bacteria
C4901_07010	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4901_07030	COG0513	Belongs to the DEAD box helicase family
C4901_07040	COG3344	reverse transcriptase
C4901_07045	COG3706	GGDEF domain
C4901_07055	COG1968	undecaprenyl-diphosphatase activity
C4901_07060	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C4901_07080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4901_07085	COG0481	GTPase activity
C4901_07100	COG0571	ribonuclease III activity
C4901_07105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4901_07110	COG1381	Involved in DNA repair and RecF pathway recombination
C4901_07130	COG3609	addiction module antidote protein, CC2985 family
C4901_07135	COG0736	holo-[acyl-carrier-protein] synthase activity
C4901_07150	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4901_07155	COG0316	Belongs to the HesB IscA family
C4901_07160	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4901_07185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4901_07225	COG0625	glutathione transferase activity
C4901_07240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4901_07265	COG0475	glutathione-regulated potassium exporter activity
C4901_07415	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4901_07465	COG1484	DNA-dependent DNA replication
C4901_07490	COG2801	Transposase and inactivated derivatives
C4901_07535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4901_07535	COG0574	Belongs to the PEP-utilizing enzyme family
C4901_07540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4901_07610	COG1047	Peptidyl-prolyl cis-trans
C4901_07650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4901_07685	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4901_07690	COG3226	Transcriptional regulator
C4901_07695	COG1741	Belongs to the pirin family
C4901_07700	COG0655	NAD(P)H dehydrogenase (quinone) activity
C4901_07705	COG1733	regulation of RNA biosynthetic process
C4901_07710	COG1322	Protein conserved in bacteria
C4901_07715	COG0488	(ABC) transporter
C4901_07720	COG0726	polysaccharide deacetylase
C4901_07755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4901_07770	COG1064	alcohol dehydrogenase
C4901_07775	COG2197	response regulator
C4901_07800	COG2346	COG2346, Truncated hemoglobins
C4901_07805	COG1959	2 iron, 2 sulfur cluster binding
C4901_07835	COG0277	FAD linked oxidase domain protein
C4901_07840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4901_07845	COG2733	membrane
C4901_07855	COG1280	lysine exporter protein (LysE YggA)
C4901_07865	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4901_07870	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C4901_07880	COG0494	nUDIX hydrolase
C4901_07900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4901_07905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4901_07910	COG1538	Outer membrane efflux protein
C4901_07915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4901_07920	COG0589	response to stress
C4901_07940	COG1070	Carbohydrate kinase
C4901_07945	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4901_07950	COG1196	nuclear chromosome segregation
C4901_07955	COG3115	cell septum assembly
C4901_07960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4901_07965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4901_07975	COG2350	Protein conserved in bacteria
C4901_07985	COG0613	PHP domain protein
C4901_07990	COG0009	L-threonylcarbamoyladenylate synthase
C4901_07995	COG1994	Peptidase M50
C4901_08000	COG0180	Tryptophanyl-tRNA synthetase
C4901_08005	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C4901_08015	COG1187	pseudouridine synthase activity
C4901_08030	COG0228	four-way junction DNA binding
C4901_08035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4901_08040	COG0336	Belongs to the RNA methyltransferase TrmD family
C4901_08045	COG0335	large ribosomal subunit rRNA binding
C4901_08065	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4901_08080	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C4901_08085	COG0668	transmembrane transport
C4901_08095	COG2027	D-alanyl-D-alanine carboxypeptidase
C4901_08100	COG0372	Belongs to the citrate synthase family
C4901_08105	COG1605	Chorismate mutase
C4901_08105	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C4901_08110	COG1278	Cold shock
C4901_08115	COG0586	Pfam SNARE associated Golgi protein
C4901_08145	COG0675	Transposase, IS605 OrfB family
C4901_08155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4901_08155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4901_08160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4901_08165	COG2957	Belongs to the agmatine deiminase family
C4901_08205	COG1187	pseudouridine synthase activity
C4901_08210	COG0129	dihydroxy-acid dehydratase activity
C4901_08220	COG3568	Endonuclease Exonuclease Phosphatase
C4901_08225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4901_08235	COG0789	Transcriptional regulator
C4901_08255	COG0482	sulfurtransferase activity
C4901_08290	COG1278	Cold shock
C4901_08295	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4901_08300	COG0542	response to heat
C4901_08310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4901_08315	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4901_08320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4901_08340	COG0045	succinate-CoA ligase (ADP-forming) activity
C4901_08345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C4901_08350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C4901_08355	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4901_08355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4901_08375	COG0693	protein deglycase activity
C4901_08385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4901_08405	COG2095	MarC family integral membrane protein
C4901_08410	COG0542	response to heat
C4901_08415	COG1607	acyl-coa hydrolase
C4901_08425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4901_08430	COG2814	Major facilitator Superfamily
C4901_08440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4901_08445	COG0066	3-isopropylmalate dehydratase activity
C4901_08450	COG0473	3-isopropylmalate dehydrogenase activity
C4901_08455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C4901_08470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4901_08485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4901_08575	COG0768	penicillin binding
C4901_08585	COG0583	DNA-binding transcription factor activity
C4901_08595	COG5001	Diguanylate cyclase
C4901_08600	COG3260	NADH ubiquinone oxidoreductase 20
C4901_08605	COG0649	NAD binding
C4901_08610	COG0651	ATP synthesis coupled electron transport
C4901_08620	COG0650	Formate hydrogenlyase subunit 4
C4901_08665	COG0330	HflC and HflK could
C4901_08675	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4901_08680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4901_08690	COG0557	exoribonuclease II activity
C4901_08695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4901_08700	COG0360	Binds together with S18 to 16S ribosomal RNA
C4901_08705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4901_08715	COG0305	Participates in initiation and elongation during chromosome replication
C4901_08720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4901_08730	COG5001	Diguanylate cyclase
C4901_08750	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_08760	COG2855	membrane
C4901_08765	COG2116	formate transmembrane transporter activity
C4901_08775	COG0028	Belongs to the TPP enzyme family
C4901_08785	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4901_08790	COG0424	maF-like protein
C4901_08795	COG5016	pyruvate
C4901_08795	COG0511	ligase activity, forming carbon-carbon bonds
C4901_08800	COG0439	Biotin carboxylase
C4901_08815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4901_08820	COG0416	fatty acid biosynthetic process
C4901_08825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4901_08830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4901_08835	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_08840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4901_08845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4901_08850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4901_08855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4901_08860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4901_08865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4901_08880	COG0084	hydrolase, TatD family'
C4901_08930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4901_08960	COG2192	nodulation
C4901_08965	COG0859	PFAM glycosyl transferase family 9
C4901_08970	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4901_08975	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_08980	COG0438	transferase activity, transferring glycosyl groups
C4901_08985	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4901_09000	COG2890	protein-(glutamine-N5) methyltransferase activity
C4901_09010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4901_09215	COG0732	type I restriction modification DNA specificity domain
C4901_09260	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4901_09355	COG1432	Conserved Protein
C4901_09405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4901_09410	COG0322	excinuclease ABC activity
C4901_09415	COG1573	uracil-dna glycosylase
C4901_09420	COG1472	Belongs to the glycosyl hydrolase 3 family
C4901_09425	COG1376	ErfK ybiS ycfS ynhG family protein
C4901_09430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4901_09445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4901_09450	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
C4901_09455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C4901_09465	COG0436	Aminotransferase
C4901_09485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4901_09490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4901_09495	COG0616	signal peptide processing
C4901_09505	COG0546	phosphoglycolate phosphatase activity
C4901_09525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4901_09530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4901_09540	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4901_09545	COG2835	tetraacyldisaccharide 4'-kinase activity
C4901_09550	COG1663	tetraacyldisaccharide 4'-kinase activity
C4901_09560	COG1132	(ABC) transporter
C4901_09570	COG0811	peptide transport
C4901_09575	COG1136	(ABC) transporter
C4901_09580	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4901_09590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C4901_09605	COG2171	N-acyltransferase activity
C4901_09610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4901_09615	COG1716	ATPase activity
C4901_09630	COG0745	RESPONSE REGULATOR receiver
C4901_09645	COG1218	3'(2'),5'-bisphosphate nucleotidase
C4901_09665	COG0675	Transposase, IS605 OrfB family
C4901_09670	COG2226	methyltransferase
C4901_09675	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4901_09680	COG0243	molybdopterin cofactor binding
C4901_09685	COG0437	4 iron, 4 sulfur cluster binding
C4901_09690	COG3302	dmso reductase anchor subunit
C4901_09695	COG0315	cyclic pyranopterin monophosphate synthase activity
C4901_09705	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4901_09710	COG0314	molybdopterin synthase activity
C4901_09715	COG0488	(ABC) transporter
C4901_09730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4901_09760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4901_09815	COG2378	regulation of single-species biofilm formation
C4901_09825	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_09840	COG1252	NADH dehydrogenase
C4901_09870	COG1566	PFAM secretion protein HlyD family protein
C4901_09895	COG2217	Heavy metal translocating P-type atpase
C4901_09900	COG2217	Heavy metal translocating P-type atpase
C4901_09930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C4901_09930	COG0678	peroxiredoxin activity
C4901_09940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4901_09945	COG2719	SpoVR family
C4901_09950	COG2718	Belongs to the UPF0229 family
C4901_09955	COG2766	serine protein kinase
C4901_09965	COG2223	nitrite transmembrane transporter activity
C4901_09990	COG0697	spore germination
C4901_10015	COG1741	Belongs to the pirin family
C4901_10040	COG3002	Belongs to the UPF0753 family
C4901_10050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4901_10075	COG2193	ferroxidase activity
C4901_10120	COG1850	ribulose-bisphosphate carboxylase activity
C4901_10130	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4901_10150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4901_10155	COG1923	regulation of RNA biosynthetic process
C4901_10160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4901_10165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4901_10275	COG2814	Major facilitator Superfamily
C4901_10300	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4901_10305	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4901_10310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4901_10315	COG1053	succinate dehydrogenase
C4901_10340	COG0148	phosphopyruvate hydratase activity
C4901_10345	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4901_10350	COG0504	CTP synthase activity
C4901_10355	COG0037	tRNA processing
C4901_10360	COG0825	malonyl-CoA metabolic process
C4901_10365	COG0587	DNA-directed DNA polymerase activity
C4901_10370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4901_10375	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4901_10385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4901_10405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4901_10410	COG0575	Belongs to the CDS family
C4901_10415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4901_10425	COG0528	UMP kinase activity
C4901_10430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4901_10435	COG0052	Belongs to the universal ribosomal protein uS2 family
C4901_10440	COG0024	Methionine aminopeptidase
C4901_10510	COG0531	amino acid
C4901_10515	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4901_10520	COG0802	atpase or kinase
C4901_10525	COG0802	atpase or kinase
C4901_10530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4901_10530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4901_10535	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4901_10540	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4901_10545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4901_10550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4901_10585	COG3237	CsbD-like
C4901_10610	COG4566	intracellular signal transduction
C4901_10650	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4901_10655	COG0590	tRNA wobble adenosine to inosine editing
C4901_10690	COG4454	pyrroloquinoline quinone binding
C4901_10695	COG0109	protoheme IX farnesyltransferase activity
C4901_10715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4901_10740	COG0653	protein targeting
C4901_10755	COG0517	IMP dehydrogenase activity
C4901_10760	COG4974	Belongs to the 'phage' integrase family
C4901_10765	COG0519	Catalyzes the synthesis of GMP from XMP
C4901_10765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4901_10780	COG1570	exodeoxyribonuclease VII activity
C4901_10780	COG1570	exodeoxyribonuclease VII activity
C4901_10785	COG1160	GTP binding
C4901_10800	COG0124	histidyl-tRNA synthetase
C4901_10805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4901_10820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4901_10825	COG0105	UTP biosynthetic process
C4901_10840	COG0443	Heat shock 70 kDa protein
C4901_10845	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4901_10850	COG0316	Belongs to the HesB IscA family
C4901_10855	COG0822	iron-sulfur transferase activity
C4901_10860	COG1104	cysteine desulfurase activity
C4901_10875	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C4901_10900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4901_10905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C4901_10910	COG4536	flavin adenine dinucleotide binding
C4901_10915	COG1193	negative regulation of DNA recombination
C4901_10920	COG1214	PFAM Peptidase M22, glycoprotease
C4901_10930	COG0667	Aldo Keto reductase
C4901_10965	COG1002	Type II restriction enzyme, methylase subunits
C4901_10970	COG1061	Type III restriction enzyme res subunit
C4901_10975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4901_11050	COG2944	sequence-specific DNA binding
C4901_11100	COG4372	Transposase
C4901_11125	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4901_11205	COG3609	addiction module antidote protein, CC2985 family
C4901_11275	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4901_11280	COG0527	aspartate kinase activity
C4901_11285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4901_11290	COG2137	regulation of response to DNA damage stimulus
C4901_11295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4901_11305	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4901_11310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C4901_11315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4901_11320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C4901_11330	COG2815	serine threonine protein kinase
C4901_11330	COG0515	serine threonine protein kinase
C4901_11345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4901_11345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4901_11350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4901_11355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4901_11360	COG2703	oxygen carrier activity
C4901_11375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4901_11385	COG0343	queuine tRNA-ribosyltransferase activity
C4901_11395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4901_11455	COG1061	Type III restriction enzyme res subunit
C4901_11460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4901_11635	COG5001	Diguanylate cyclase
C4901_11715	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C4901_11720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4901_11725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4901_11740	COG0617	tRNA 3'-terminal CCA addition
C4901_11750	COG3118	belongs to the thioredoxin family
C4901_11780	COG0438	transferase activity, transferring glycosyl groups
C4901_11790	COG0463	Glycosyl transferase, family 2
C4901_11795	COG0438	transferase activity, transferring glycosyl groups
C4901_11795	COG0297	glycogen (starch) synthase activity
C4901_11800	COG0110	maltose O-acetyltransferase activity
C4901_11815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4901_11820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4901_11825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4901_11830	COG0318	PFAM AMP-dependent synthetase and ligase
C4901_11835	COG0367	asparagine synthase
C4901_11840	COG3267	Type II secretory pathway component ExeA
C4901_11840	COG3409	Peptidoglycan-binding domain 1 protein
C4901_11865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4901_11875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4901_11880	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4901_11885	COG1674	ftsk spoiiie
C4901_11890	COG0686	Belongs to the AlaDH PNT family
C4901_11895	COG0492	ferredoxin-NADP+ reductase activity
C4901_11905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4901_11910	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4901_11920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4901_11930	COG0242	peptide deformylase activity
C4901_11955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C4901_11965	COG4221	oxidoreductase activity
C4901_11980	COG1850	ribulose-bisphosphate carboxylase activity
C4901_12000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4901_12015	COG1132	(ABC) transporter
C4901_12025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4901_12030	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4901_12030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4901_12035	COG0284	orotidine-5'-phosphate decarboxylase activity
C4901_12040	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C4901_12050	COG0776	regulation of translation
C4901_12055	COG0539	negative regulation of cytoplasmic translation
C4901_12060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4901_12065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4901_12070	COG0287	Prephenate dehydrogenase
C4901_12075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4901_12085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4901_12090	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4901_12130	COG3436	PFAM IS66 Orf2 family protein
C4901_12185	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C4901_12190	COG2204	response regulator
C4901_12210	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C4901_12220	COG0375	protein maturation
C4901_12240	COG0298	carbon dioxide binding
C4901_12285	COG4191	Histidine kinase
C4901_12300	COG2271	Major facilitator Superfamily
C4901_12310	COG5001	Diguanylate cyclase
C4901_12320	COG0418	dihydroorotase activity
C4901_12325	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4901_12330	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4901_12380	COG3384	dioxygenase
C4901_12385	COG1252	NADH dehydrogenase
C4901_12400	COG4451	ribulose bisphosphate carboxylase, small
C4901_12410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4901_12415	COG0028	Belongs to the TPP enzyme family
C4901_12435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C4901_12455	COG0746	molybdenum cofactor guanylyltransferase activity
C4901_12475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4901_12480	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4901_12500	COG4133	protoheme IX ABC transporter activity
C4901_12510	COG3088	subunit of a heme lyase
C4901_12515	COG1138	Cytochrome C-type biogenesis protein
C4901_12530	COG0795	lipopolysaccharide-transporting ATPase activity
C4901_12535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4901_12555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4901_12565	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4901_12570	COG0456	acetyltransferase
C4901_12575	COG1573	uracil-dna glycosylase
C4901_12635	COG2920	part of a sulfur-relay system
C4901_12640	COG2827	Endonuclease containing a URI domain
C4901_12650	COG0587	DNA-directed DNA polymerase activity
C4901_12670	COG0604	alcohol dehydrogenase
C4901_12670	COG3321	synthase
C4901_12670	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_12690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4901_12705	COG1183	phosphatidylcholine synthase activity
C4901_12710	COG0688	phosphatidylethanolamine metabolic process
C4901_12715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4901_12720	COG0440	acetolactate synthase activity
C4901_12725	COG0028	Belongs to the TPP enzyme family
C4901_12750	COG0215	cysteine-tRNA ligase activity
C4901_12755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4901_12760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4901_12765	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4901_12795	COG0285	dihydrofolate synthase activity
C4901_12805	COG0159	tryptophan synthase activity
C4901_12810	COG0133	tryptophan synthase activity
C4901_12815	COG0135	phosphoribosylanthranilate isomerase activity
C4901_12830	COG0583	DNA-binding transcription factor activity
C4901_12880	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4901_12925	COG0644	oxidoreductase
C4901_12930	COG0095	Lipoate-protein ligase
C4901_12940	COG0509	glycine decarboxylation via glycine cleavage system
C4901_12950	COG0509	glycine decarboxylation via glycine cleavage system
C4901_12955	COG2048	Heterodisulfide reductase, subunit B
C4901_12985	COG2210	Belongs to the sulfur carrier protein TusA family
C4901_12990	COG0425	Belongs to the sulfur carrier protein TusA family
C4901_12995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4901_13030	COG3258	Cytochrome c
C4901_13065	COG2095	MarC family integral membrane protein
C4901_13070	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C4901_13080	COG2204	response regulator
C4901_13090	COG2205	protein histidine kinase activity
C4901_13095	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4901_13100	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C4901_13130	COG3547	Transposase (IS116 IS110 IS902 family)
C4901_13135	COG1450	Type ii and iii secretion system protein
C4901_13145	COG3547	Transposase (IS116 IS110 IS902 family)
C4901_13150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4901_13165	COG3436	PFAM IS66 Orf2 family protein
C4901_13175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4901_13180	COG1459	type II secretion system
C4901_13210	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4901_13220	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4901_13240	COG2202	Pas domain
C4901_13240	COG2205	protein histidine kinase activity
C4901_13245	COG1408	metallophosphoesterase
C4901_13275	COG3706	GGDEF domain
C4901_13310	COG0811	peptide transport
C4901_13325	COG3608	succinylglutamate desuccinylase aspartoacylase
C4901_13325	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4901_13360	COG1335	isochorismatase
C4901_13365	COG0402	S-adenosylhomocysteine deaminase activity
C4901_13410	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C4901_13415	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C4901_13420	COG0295	cytidine deaminase activity
C4901_13445	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4901_13450	COG1309	transcriptional regulator
C4901_13455	COG2814	Major facilitator Superfamily
C4901_13475	COG0784	Response regulator, receiver
C4901_13485	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C4901_13500	COG1215	transferase activity, transferring glycosyl groups
C4901_13510	COG3436	PFAM IS66 Orf2 family protein
C4901_13585	COG3547	Transposase (IS116 IS110 IS902 family)
C4901_13615	COG3436	PFAM IS66 Orf2 family protein
C4901_13670	COG3436	PFAM IS66 Orf2 family protein
C4901_13765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4901_13770	COG0602	queuosine metabolic process
C4901_13805	COG0824	Thioesterase
C4901_13810	COG2255	four-way junction helicase activity
C4901_13820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4901_13825	COG0217	transcriptional regulatory protein
C4901_13840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4901_13870	COG0517	IMP dehydrogenase activity
C4901_13870	COG0516	GMP reductase activity
C4901_13890	COG1929	Belongs to the glycerate kinase type-1 family
C4901_13905	COG1960	acyl-CoA dehydrogenase activity
C4901_13910	COG3258	Cytochrome c
C4901_13925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4901_13970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4901_13985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4901_13985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4901_13990	COG0859	PFAM glycosyl transferase family 9
C4901_13995	COG0203	ribosomal protein L17
C4901_14000	COG0202	RNA polymerase activity
C4901_14005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4901_14010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4901_14015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4901_14020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4901_14025	COG0201	protein transport
C4901_14030	COG0200	Binds to the 23S rRNA
C4901_14035	COG1841	ribosomal large subunit assembly
C4901_14040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4901_14045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4901_14050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4901_14055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4901_14065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4901_14070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4901_14075	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4901_14080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4901_14085	COG0255	Belongs to the universal ribosomal protein uL29 family
C4901_14090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4901_14095	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4901_14100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4901_14105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4901_14110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4901_14115	COG0089	rRNA binding
C4901_14120	COG0088	Forms part of the polypeptide exit tunnel
C4901_14125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4901_14130	COG0051	transcription antitermination factor activity, RNA binding
C4901_14135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4901_14140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4901_14145	COG0049	tRNA binding
C4901_14150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4901_14155	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4901_14160	COG0085	RNA polymerase activity
C4901_14165	COG0222	ribosome binding
C4901_14170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4901_14175	COG0081	regulation of translation
C4901_14180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4901_14185	COG0250	Participates in transcription elongation, termination and antitermination
C4901_14190	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4901_14205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4901_14250	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4901_14255	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C4901_14255	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C4901_14295	COG0316	Belongs to the HesB IscA family
C4901_14310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4901_14355	COG3411	Ferredoxin
C4901_14360	COG0247	lactate metabolic process
C4901_14365	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4901_14375	COG1765	OsmC-like protein
C4901_14380	COG0134	indole-3-glycerol-phosphate synthase activity
C4901_14385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4901_14395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4901_14400	COG0546	phosphoglycolate phosphatase activity
C4901_14410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4901_14415	COG0363	glucosamine-6-phosphate deaminase activity
C4901_14425	COG0848	biopolymer transport protein
C4901_14430	COG0811	peptide transport
C4901_14440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4901_14465	COG0469	pyruvate kinase activity
C4901_14470	COG0126	phosphoglycerate kinase activity
C4901_14475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4901_14480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4901_14485	COG0572	uridine kinase
C4901_14490	COG0483	inositol monophosphate 1-phosphatase activity
C4901_14515	COG0643	Histidine kinase
C4901_14515	COG2198	Histidine kinase
C4901_14520	COG0840	transmembrane signaling receptor activity
C4901_14545	COG0189	ligase activity
C4901_14555	COG1678	Uncharacterized ACR, COG1678
C4901_14560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4901_14565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4901_14570	COG0540	Belongs to the ATCase OTCase family
C4901_14590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4901_14615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4901_14625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4901_14630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4901_14635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4901_14635	COG2813	Specifically methylates the guanine in position
C4901_14640	COG2807	transmembrane transport
C4901_14645	COG0708	Exodeoxyribonuclease III
C4901_14655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4901_14670	COG2046	Belongs to the sulfate adenylyltransferase family
C4901_14690	COG3300	MHYT domain
C4901_14690	COG5001	Diguanylate cyclase
C4901_14705	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
C4901_14725	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C4901_14730	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C4901_14740	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C4901_14745	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C4901_14750	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
C4901_14765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4901_14775	COG5554	nitrogen fixation
C4901_14785	COG5554	nitrogen fixation
C4901_14795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4901_14810	COG0316	Belongs to the HesB IscA family
C4901_14815	COG5001	Diguanylate cyclase
C4901_14815	COG3300	MHYT domain
C4901_14855	COG0822	iron-sulfur transferase activity
C4901_14935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4901_14940	COG0009	L-threonylcarbamoyladenylate synthase
C4901_14945	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C4901_14950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4901_14960	COG0418	dihydroorotase activity
C4901_14970	COG3002	Belongs to the UPF0753 family
C4901_14975	COG0191	fructose-bisphosphate aldolase activity
C4901_14980	COG0583	DNA-binding transcription factor activity
C4901_15010	COG3300	MHYT domain
C4901_15010	COG5001	Diguanylate cyclase
C4901_15030	COG3002	Belongs to the UPF0753 family
C4901_15035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4901_15065	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C4901_15075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4901_15120	COG3311	Transcriptional regulator
C4901_15125	COG1569	PIN domain
C4901_15255	COG3609	addiction module antidote protein, CC2985 family
C4901_15285	COG4227	nucleotidyltransferase activity
C4901_15305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4901_15490	COG5001	Diguanylate cyclase
C4901_15505	COG0450	alkyl hydroperoxide reductase
C4901_15510	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4901_15515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4901_15535	COG0175	sulfate reduction
C4901_15540	COG0583	DNA-binding transcription factor activity
C4901_15565	COG2857	Cytochrome c1
C4901_15575	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4901_15595	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_15600	COG2863	cytochrome
C4901_15615	COG3300	MHYT domain
C4901_15615	COG5001	Diguanylate cyclase
C4901_15645	COG0601	transmembrane transport
C4901_15655	COG0444	Belongs to the ABC transporter superfamily
C4901_15660	COG4608	Belongs to the ABC transporter superfamily
C4901_15665	COG0210	DNA helicase
C4901_15675	COG0477	Major facilitator Superfamily
C4901_15680	COG0640	Transcriptional regulator
C4901_15760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4901_15775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4901_15785	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4901_15790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4901_15825	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_15845	COG0617	tRNA 3'-terminal CCA addition
C4901_15870	COG1012	belongs to the aldehyde dehydrogenase family
C4901_15885	COG1331	Highly conserved protein containing a thioredoxin domain
C4901_15890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4901_15910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4901_15920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4901_15930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4901_15955	COG1215	transferase activity, transferring glycosyl groups
C4901_15970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4901_15995	COG0708	Exodeoxyribonuclease III
C4901_16005	COG0339	signal peptide processing
C4901_16010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4901_16020	COG0625	glutathione transferase activity
C4901_16025	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4901_16040	COG1196	nuclear chromosome segregation
C4901_16065	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4901_16075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4901_16085	COG0194	GDP metabolic process
C4901_16095	COG0631	protein serine/threonine phosphatase activity
C4901_16100	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4901_16105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4901_16110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4901_16185	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4901_16190	COG0830	nickel cation binding
C4901_16195	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4901_16200	COG0804	urea catabolic process
C4901_16205	COG0832	Belongs to the urease beta subunit family
C4901_16215	COG0829	nickel cation binding
C4901_16225	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4901_16255	COG0003	Pfam Anion-transporting ATPase
C4901_16265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4901_16270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4901_16275	COG0493	'glutamate synthase
C4901_16280	COG0067	glutamate synthase
C4901_16280	COG0069	glutamate synthase activity
C4901_16280	COG0070	glutamate synthase
C4901_16285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4901_16290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4901_16350	COG0018	arginyl-trna synthetase
C4901_16360	COG2897	thiosulfate sulfurtransferase activity
C4901_16365	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C4901_16370	COG1116	anion transmembrane transporter activity
C4901_16375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4901_16380	COG1116	anion transmembrane transporter activity
C4901_16380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4901_16400	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C4901_16410	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C4901_16415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4901_16415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4901_16430	COG1487	ribonuclease activity
C4901_16450	COG0330	HflC and HflK could
C4901_16475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4901_16490	COG1846	Transcriptional regulator
C4901_16505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4901_16510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4901_16520	COG0625	glutathione transferase activity
C4901_16535	COG1618	nucleotide phosphatase activity, acting on free nucleotides
C4901_16535	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4901_16540	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4901_16545	COG0303	'Molybdopterin
C4901_16550	COG0746	molybdenum cofactor guanylyltransferase activity
C4901_16555	COG1432	Conserved Protein
C4901_16560	COG0243	molybdopterin cofactor binding
C4901_16570	COG2223	nitrite transmembrane transporter activity
C4901_16595	COG0004	ammonium transporteR
C4901_16600	COG0347	Belongs to the P(II) protein family
C4901_16605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4901_16610	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4901_16695	COG1074	ATP-dependent DNA helicase activity
C4901_16720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4901_16755	COG3387	PFAM Glycoside hydrolase 15-related
C4901_16760	COG0254	rRNA binding
C4901_16765	COG0281	malic enzyme
C4901_16770	COG2890	protein-(glutamine-N5) methyltransferase activity
C4901_16790	COG1022	Amp-dependent synthetase and ligase
C4901_16795	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4901_16795	COG1024	Enoyl-CoA hydratase
C4901_16800	COG0183	Belongs to the thiolase family
C4901_16805	COG1960	acyl-CoA dehydrogenase activity
C4901_16825	COG0135	phosphoribosylanthranilate isomerase activity
C4901_16870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4901_16880	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C4901_16885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4901_16905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4901_16905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4901_16910	COG1611	Belongs to the LOG family
C4901_16915	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4901_16930	COG0210	DNA helicase
C4901_16950	COG1842	Phage shock protein A
C4901_16970	COG1192	Involved in chromosome partitioning
C4901_16975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4901_16980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4901_16985	COG1047	Peptidyl-prolyl cis-trans
C4901_16990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4901_16995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4901_17000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4901_17005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4901_17010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4901_17015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4901_17020	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4901_17025	COG0356	it plays a direct role in the translocation of protons across the membrane
C4901_17040	COG1475	DNA binding
C4901_17045	COG1192	Involved in chromosome partitioning
C4901_17055	COG0445	tRNA wobble uridine modification
C4901_17090	COG0714	Associated with various cellular activities
C4901_17105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4901_17110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4901_17115	COG0706	membrane insertase activity
C4901_17120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4901_17125	COG0594	ribonuclease P activity