locus-tag	class	description
A9R16_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A9R16_000015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A9R16_000030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A9R16_000035	COG2022	thiamine diphosphate biosynthetic process
A9R16_000070	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A9R16_000075	COG0412	Dienelactone hydrolase
A9R16_000095	COG3093	addiction module antidote protein HigA
A9R16_000125	COG0420	3'-5' exonuclease activity
A9R16_000145	COG4584	PFAM Integrase catalytic
A9R16_000150	COG1484	DNA-dependent DNA replication
A9R16_000195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A9R16_000205	COG1011	Hydrolase
A9R16_000220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9R16_000240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A9R16_000255	COG1519	Transferase
A9R16_000260	COG0859	PFAM glycosyl transferase family 9
A9R16_000275	COG0297	glycogen (starch) synthase activity
A9R16_000280	COG0859	PFAM glycosyl transferase family 9
A9R16_000305	COG0438	transferase activity, transferring glycosyl groups
A9R16_000310	COG0859	PFAM glycosyl transferase family 9
A9R16_000335	COG0859	PFAM glycosyl transferase family 9
A9R16_000355	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A9R16_000370	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A9R16_000375	COG1850	ribulose-bisphosphate carboxylase activity
A9R16_000380	COG0235	Class ii aldolase
A9R16_000425	COG0408	coproporphyrinogen oxidase activity
A9R16_000430	COG0151	Belongs to the GarS family
A9R16_000435	COG0138	bifunctional purine biosynthesis protein purh
A9R16_000440	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A9R16_000455	COG2264	protein methyltransferase activity
A9R16_000460	COG0439	Biotin carboxylase
A9R16_000465	COG0511	ligase activity, forming carbon-carbon bonds
A9R16_000470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A9R16_000475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9R16_000480	COG4232	protein-disulfide reductase activity
A9R16_000485	COG1324	tolerance protein
A9R16_000495	COG3030	protein affecting phage T7 exclusion by the F plasmid
A9R16_000500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A9R16_000505	COG0459	protein refolding
A9R16_000525	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A9R16_000525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A9R16_000530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A9R16_000540	COG1028	Short-chain dehydrogenase reductase Sdr
A9R16_000570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A9R16_000580	COG0352	thiamine-phosphate diphosphorylase activity
A9R16_000585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A9R16_000595	COG2199	diguanylate cyclase activity
A9R16_000605	COG2967	ApaG domain
A9R16_000610	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A9R16_000620	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A9R16_000625	COG1217	gtp-binding protein TYPA
A9R16_000645	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A9R16_000650	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A9R16_000655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A9R16_000660	COG0037	tRNA processing
A9R16_000665	COG1560	Kdo2-lipid A biosynthetic process
A9R16_000675	COG1560	Kdo2-lipid A biosynthetic process
A9R16_000685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A9R16_000690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A9R16_000695	COG0242	peptide deformylase activity
A9R16_000705	COG2922	Belongs to the Smg family
A9R16_000715	COG4232	protein-disulfide reductase activity
A9R16_000725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A9R16_000730	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A9R16_000740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9R16_000750	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A9R16_000755	COG4942	peptidase
A9R16_000760	COG0793	Belongs to the peptidase S41A family
A9R16_000775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A9R16_000790	COG2226	methyltransferase
A9R16_000800	COG0745	RESPONSE REGULATOR receiver
A9R16_000820	COG2188	Transcriptional regulator
A9R16_000840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A9R16_000845	COG0704	Plays a role in the regulation of phosphate uptake
A9R16_000855	COG0563	adenylate kinase activity
A9R16_000865	COG0205	6-phosphofructokinase activity
A9R16_000875	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A9R16_000895	COG2076	Multidrug Resistance protein
A9R16_000900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A9R16_000920	COG0726	polysaccharide deacetylase
A9R16_000925	COG1643	Atp-dependent helicase
A9R16_000930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A9R16_000955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A9R16_000965	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A9R16_000970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A9R16_000975	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A9R16_000980	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A9R16_000985	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A9R16_000995	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A9R16_001005	COG0751	glycine-tRNA ligase activity
A9R16_001010	COG0752	glycyl-tRNA synthetase alpha subunit
A9R16_001020	COG0482	sulfurtransferase activity
A9R16_001035	COG0174	glutamine synthetase
A9R16_001045	COG0675	Transposase, IS605 OrfB family
A9R16_001050	COG2706	6-phosphogluconolactonase activity
A9R16_001105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9R16_001105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A9R16_001115	COG1242	4 iron, 4 sulfur cluster binding
A9R16_001120	COG0826	peptidase U32
A9R16_001125	COG0826	peptidase U32
A9R16_001170	COG2070	2-Nitropropane dioxygenase
A9R16_001180	COG1272	protein, Hemolysin III
A9R16_001205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A9R16_001210	COG0321	lipoyl(octanoyl) transferase activity
A9R16_001215	COG2921	Belongs to the UPF0250 family
A9R16_001230	COG0772	Belongs to the SEDS family
A9R16_001235	COG0768	penicillin binding
A9R16_001240	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A9R16_001245	COG1792	Involved in formation and maintenance of cell shape
A9R16_001250	COG1077	Cell shape determining protein MreB Mrl
A9R16_001255	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A9R16_001260	COG0154	amidase activity
A9R16_001265	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A9R16_001270	COG2226	methyltransferase
A9R16_001280	COG0583	DNA-binding transcription factor activity
A9R16_001310	COG1233	COG1233 Phytoene dehydrogenase and related
A9R16_001315	COG3976	FMN-binding domain protein
A9R16_001315	COG1053	succinate dehydrogenase
A9R16_001325	COG2048	Heterodisulfide reductase, subunit B
A9R16_001365	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A9R16_001370	COG1914	H( )-stimulated, divalent metal cation uptake system
A9R16_001375	COG3852	Histidine kinase
A9R16_001380	COG2204	response regulator
A9R16_001395	COG1127	ABC transporter
A9R16_001400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A9R16_001405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A9R16_001410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A9R16_001415	COG0006	proline dipeptidase activity
A9R16_001440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A9R16_001445	COG1692	metallophosphoesterase
A9R16_001465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A9R16_001485	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A9R16_001490	COG0604	alcohol dehydrogenase
A9R16_001530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A9R16_001535	COG1459	type II secretion system
A9R16_001565	COG3267	Type II secretory pathway component ExeA
A9R16_001565	COG3409	Peptidoglycan-binding domain 1 protein
A9R16_001580	COG0156	8-amino-7-oxononanoate synthase activity
A9R16_001585	COG2267	carboxylic ester hydrolase activity
A9R16_001590	COG2226	methyltransferase
A9R16_001650	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A9R16_001675	COG2177	Part of the ABC transporter FtsEX involved in
A9R16_001680	COG2884	Cell division ATP-binding protein ftsE
A9R16_001685	COG0552	protein localization to endoplasmic reticulum
A9R16_001690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A9R16_001695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A9R16_001700	COG0742	ribosomal rna small subunit methyltransferase
A9R16_001715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A9R16_001735	COG1131	(ABC) transporter
A9R16_001760	COG3071	HemY protein
A9R16_001775	COG0181	hydroxymethylbilane synthase activity
A9R16_001795	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A9R16_001805	COG0477	Major facilitator Superfamily
A9R16_001810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9R16_001825	COG0165	Argininosuccinate lyase
A9R16_001830	COG3275	phosphorelay sensor kinase activity
A9R16_001845	COG1215	transferase activity, transferring glycosyl groups
A9R16_001850	COG1335	isochorismatase
A9R16_001860	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A9R16_001875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A9R16_001885	COG1965	Belongs to the frataxin family
A9R16_001905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A9R16_001915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A9R16_001930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A9R16_001935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A9R16_001950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A9R16_001960	COG1309	transcriptional regulator
A9R16_001980	COG2890	protein-(glutamine-N5) methyltransferase activity
A9R16_001985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A9R16_001990	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A9R16_002005	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A9R16_002010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A9R16_002020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A9R16_002025	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A9R16_002030	COG0193	aminoacyl-tRNA hydrolase activity
A9R16_002035	COG0012	GTP binding
A9R16_002085	COG2308	Evidence 4 Homologs of previously reported genes of
A9R16_002125	COG1993	acr, cog1993
A9R16_002130	COG0651	ATP synthesis coupled electron transport
A9R16_002135	COG3260	NADH ubiquinone oxidoreductase 20
A9R16_002140	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A9R16_002140	COG3261	NADH dehydrogenase
A9R16_002145	COG0651	ATP synthesis coupled electron transport
A9R16_002155	COG0650	Formate hydrogenlyase subunit 4
A9R16_002170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A9R16_002225	COG1295	ribonuclease BN
A9R16_002230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A9R16_002260	COG0545	Peptidyl-prolyl cis-trans isomerase
A9R16_002265	COG1278	Cold shock
A9R16_002275	COG0277	FAD linked oxidase domain protein
A9R16_002280	COG0277	FAD linked oxidase domain protein
A9R16_002285	COG0247	lactate metabolic process
A9R16_002300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A9R16_002305	COG1702	phosphate starvation-inducible protein PhoH
A9R16_002310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A9R16_002315	COG4535	Mg2 and Co2 transporter CorC
A9R16_002320	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A9R16_002330	COG0540	Belongs to the ATCase OTCase family
A9R16_002335	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A9R16_002340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A9R16_002345	COG1678	Uncharacterized ACR, COG1678
A9R16_002355	COG0189	ligase activity
A9R16_002385	COG0643	Histidine kinase
A9R16_002385	COG0784	Response regulator, receiver
A9R16_002385	COG0643	Histidine kinase
A9R16_002385	COG2198	Histidine kinase
A9R16_002385	COG2198	Histidine kinase
A9R16_002385	COG0784	Response regulator, receiver
A9R16_002410	COG0483	inositol monophosphate 1-phosphatase activity
A9R16_002415	COG0572	uridine kinase
A9R16_002420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A9R16_002425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A9R16_002430	COG0126	phosphoglycerate kinase activity
A9R16_002435	COG0469	pyruvate kinase activity
A9R16_002455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A9R16_002465	COG0811	peptide transport
A9R16_002470	COG0848	biopolymer transport protein
A9R16_002485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A9R16_002495	COG0546	phosphoglycolate phosphatase activity
A9R16_002510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A9R16_002515	COG0134	indole-3-glycerol-phosphate synthase activity
A9R16_002520	COG1765	OsmC-like protein
A9R16_002530	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A9R16_002535	COG0247	lactate metabolic process
A9R16_002540	COG3411	Ferredoxin
A9R16_002550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A9R16_002575	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A9R16_002590	COG0316	Belongs to the HesB IscA family
A9R16_002630	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A9R16_002630	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A9R16_002635	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A9R16_002665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A9R16_002675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A9R16_002680	COG0250	Participates in transcription elongation, termination and antitermination
A9R16_002685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A9R16_002690	COG0081	regulation of translation
A9R16_002695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A9R16_002700	COG0222	ribosome binding
A9R16_002705	COG0085	RNA polymerase activity
A9R16_002710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A9R16_002715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A9R16_002720	COG0049	tRNA binding
A9R16_002725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A9R16_002730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A9R16_002735	COG0051	transcription antitermination factor activity, RNA binding
A9R16_002740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A9R16_002745	COG0088	Forms part of the polypeptide exit tunnel
A9R16_002750	COG0089	rRNA binding
A9R16_002755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A9R16_002760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A9R16_002765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A9R16_002775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A9R16_002780	COG0255	Belongs to the universal ribosomal protein uL29 family
A9R16_002785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A9R16_002790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A9R16_002795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A9R16_002800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A9R16_002810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A9R16_002815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A9R16_002820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A9R16_002825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A9R16_002830	COG1841	ribosomal large subunit assembly
A9R16_002835	COG0200	Binds to the 23S rRNA
A9R16_002840	COG0201	protein transport
A9R16_002845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A9R16_002850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A9R16_002855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A9R16_002860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A9R16_002865	COG0202	RNA polymerase activity
A9R16_002870	COG0203	ribosomal protein L17
A9R16_002875	COG0859	PFAM glycosyl transferase family 9
A9R16_002880	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A9R16_002880	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A9R16_002895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A9R16_002955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A9R16_002960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A9R16_003015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A9R16_003035	COG1960	acyl-CoA dehydrogenase activity
A9R16_003050	COG1929	Belongs to the glycerate kinase type-1 family
A9R16_003060	COG0516	GMP reductase activity
A9R16_003060	COG0517	IMP dehydrogenase activity
A9R16_003065	COG3001	Fructosamine kinase
A9R16_003090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A9R16_003105	COG0217	transcriptional regulatory protein
A9R16_003110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A9R16_003115	COG0632	four-way junction helicase activity
A9R16_003120	COG2255	four-way junction helicase activity
A9R16_003125	COG0824	Thioesterase
A9R16_003150	COG2885	chlorophyll binding
A9R16_003160	COG0602	queuosine metabolic process
A9R16_003165	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A9R16_003180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A9R16_003190	COG1002	Type II restriction enzyme, methylase subunits
A9R16_003195	COG1061	Type III restriction enzyme res subunit
A9R16_003200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A9R16_003285	COG2217	Heavy metal translocating P-type atpase
A9R16_003345	COG3220	belongs to the UPF0276 family
A9R16_003380	COG4372	Transposase
A9R16_003475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A9R16_003495	COG4227	nucleotidyltransferase activity
A9R16_003580	COG0375	protein maturation
A9R16_003590	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A9R16_003600	COG0409	Hydrogenase expression formation protein
A9R16_003610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A9R16_003610	COG1024	Enoyl-CoA hydratase
A9R16_003615	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A9R16_003620	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A9R16_003625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A9R16_003630	COG1215	transferase activity, transferring glycosyl groups
A9R16_003645	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A9R16_003650	COG4251	negative regulation of phosphorylation
A9R16_003670	COG2814	Major facilitator Superfamily
A9R16_003675	COG1309	transcriptional regulator
A9R16_003680	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A9R16_003705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A9R16_003710	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A9R16_003740	COG0402	S-adenosylhomocysteine deaminase activity
A9R16_003745	COG1335	isochorismatase
A9R16_003780	COG3608	succinylglutamate desuccinylase aspartoacylase
A9R16_003780	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A9R16_003790	COG1802	Transcriptional regulator
A9R16_003795	COG0811	peptide transport
A9R16_003840	COG1408	metallophosphoesterase
A9R16_003845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A9R16_003845	COG2205	protein histidine kinase activity
A9R16_003860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A9R16_003870	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A9R16_003880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A9R16_003885	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A9R16_003890	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A9R16_003895	COG2205	protein histidine kinase activity
A9R16_003900	COG5002	protein histidine kinase activity
A9R16_003905	COG2204	response regulator
A9R16_003915	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A9R16_003920	COG2095	MarC family integral membrane protein
A9R16_003930	COG5001	Diguanylate cyclase
A9R16_003940	COG3258	Cytochrome c
A9R16_003975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9R16_003980	COG0425	Belongs to the sulfur carrier protein TusA family
A9R16_003985	COG2210	Belongs to the sulfur carrier protein TusA family
A9R16_004015	COG2048	Heterodisulfide reductase, subunit B
A9R16_004020	COG0509	glycine decarboxylation via glycine cleavage system
A9R16_004030	COG0509	glycine decarboxylation via glycine cleavage system
A9R16_004045	COG0644	oxidoreductase
A9R16_004090	COG0123	including yeast histone deacetylase and acetoin utilization protein
A9R16_004110	COG0583	DNA-binding transcription factor activity
A9R16_004125	COG0135	phosphoribosylanthranilate isomerase activity
A9R16_004130	COG0133	tryptophan synthase activity
A9R16_004135	COG0159	tryptophan synthase activity
A9R16_004140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A9R16_004145	COG0285	dihydrofolate synthase activity
A9R16_004175	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9R16_004180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A9R16_004185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A9R16_004190	COG0215	cysteine-tRNA ligase activity
A9R16_004195	COG0028	Belongs to the TPP enzyme family
A9R16_004200	COG0440	acetolactate synthase activity
A9R16_004205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A9R16_004210	COG0688	phosphatidylethanolamine metabolic process
A9R16_004215	COG1183	phosphatidylcholine synthase activity
A9R16_004230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A9R16_004260	COG2827	Endonuclease containing a URI domain
A9R16_004320	COG1573	uracil-dna glycosylase
A9R16_004325	COG0456	acetyltransferase
A9R16_004330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A9R16_004335	COG1993	acr, cog1993
A9R16_004340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A9R16_004345	COG0525	valine-tRNA ligase activity
A9R16_004360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A9R16_004365	COG0795	lipopolysaccharide-transporting ATPase activity
A9R16_004380	COG1138	Cytochrome C-type biogenesis protein
A9R16_004385	COG3088	subunit of a heme lyase
A9R16_004395	COG4133	protoheme IX ABC transporter activity
A9R16_004415	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A9R16_004420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9R16_004440	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A9R16_004465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A9R16_004480	COG0028	Belongs to the TPP enzyme family
A9R16_004485	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A9R16_004495	COG4451	ribulose bisphosphate carboxylase, small
A9R16_004500	COG1850	ribulose-bisphosphate carboxylase activity
A9R16_004505	COG0583	DNA-binding transcription factor activity
A9R16_004515	COG1252	NADH dehydrogenase
A9R16_004520	COG3384	dioxygenase
A9R16_004525	COG1131	(ABC) transporter
A9R16_004530	COG0842	Transport permease protein
A9R16_004540	COG4572	Cation transport regulator
A9R16_004560	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A9R16_004570	COG0418	dihydroorotase activity
A9R16_004580	COG5001	Diguanylate cyclase
A9R16_004600	COG2271	Major facilitator Superfamily
A9R16_004645	COG0298	carbon dioxide binding
A9R16_004665	COG0375	protein maturation
A9R16_004675	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A9R16_004695	COG2204	response regulator
A9R16_004700	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A9R16_004710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A9R16_004715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A9R16_004725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A9R16_004730	COG0287	Prephenate dehydrogenase
A9R16_004735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A9R16_004740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A9R16_004745	COG0539	negative regulation of cytoplasmic translation
A9R16_004750	COG0776	regulation of translation
A9R16_004760	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A9R16_004765	COG0284	orotidine-5'-phosphate decarboxylase activity
A9R16_004770	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A9R16_004770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A9R16_004775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9R16_004785	COG1132	(ABC) transporter
A9R16_004800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A9R16_004820	COG1850	ribulose-bisphosphate carboxylase activity
A9R16_004835	COG4221	oxidoreductase activity
A9R16_004845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A9R16_004855	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A9R16_004870	COG0242	peptide deformylase activity
A9R16_004875	COG0675	Transposase, IS605 OrfB family
A9R16_004890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A9R16_004900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A9R16_004905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A9R16_004910	COG1193	negative regulation of DNA recombination
A9R16_004915	COG0492	ferredoxin-NADP+ reductase activity
A9R16_004920	COG0686	Belongs to the AlaDH PNT family
A9R16_004925	COG1674	ftsk spoiiie
A9R16_004930	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A9R16_004935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A9R16_004945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A9R16_004970	COG3409	Peptidoglycan-binding domain 1 protein
A9R16_004970	COG3267	Type II secretory pathway component ExeA
A9R16_004975	COG0367	asparagine synthase
A9R16_004980	COG0318	PFAM AMP-dependent synthetase and ligase
A9R16_004985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A9R16_004990	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A9R16_004995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A9R16_005010	COG0110	maltose O-acetyltransferase activity
A9R16_005015	COG0297	glycogen (starch) synthase activity
A9R16_005015	COG0438	transferase activity, transferring glycosyl groups
A9R16_005045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9R16_005060	COG3118	belongs to the thioredoxin family
A9R16_005070	COG0617	tRNA 3'-terminal CCA addition
A9R16_005075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A9R16_005085	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A9R16_005090	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A9R16_005095	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A9R16_005100	COG2814	Major facilitator Superfamily
A9R16_005125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A9R16_005135	COG0343	queuine tRNA-ribosyltransferase activity
A9R16_005140	COG1862	Preprotein translocase
A9R16_005145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A9R16_005160	COG2703	oxygen carrier activity
A9R16_005165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A9R16_005170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A9R16_005175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A9R16_005175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A9R16_005190	COG0515	serine threonine protein kinase
A9R16_005190	COG2815	serine threonine protein kinase
A9R16_005205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A9R16_005210	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A9R16_005230	COG2137	regulation of response to DNA damage stimulus
A9R16_005235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A9R16_005240	COG0527	aspartate kinase activity
A9R16_005245	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A9R16_005350	COG3093	addiction module antidote protein HigA
A9R16_005485	COG0667	Aldo Keto reductase
A9R16_005495	COG1214	PFAM Peptidase M22, glycoprotease
A9R16_005500	COG1193	negative regulation of DNA recombination
A9R16_005505	COG4536	flavin adenine dinucleotide binding
A9R16_005515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A9R16_005520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A9R16_005540	COG0483	inositol monophosphate 1-phosphatase activity
A9R16_005545	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A9R16_005560	COG1104	cysteine desulfurase activity
A9R16_005565	COG0822	iron-sulfur transferase activity
A9R16_005570	COG0316	Belongs to the HesB IscA family
A9R16_005575	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A9R16_005595	COG0105	UTP biosynthetic process
A9R16_005600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A9R16_005615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A9R16_005620	COG0124	histidyl-tRNA synthetase
A9R16_005635	COG1160	GTP binding
A9R16_005640	COG1570	exodeoxyribonuclease VII activity
A9R16_005655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A9R16_005655	COG0519	Catalyzes the synthesis of GMP from XMP
A9R16_005660	COG4372	Transposase
A9R16_005715	COG0653	protein targeting
A9R16_005735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A9R16_005740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A9R16_005755	COG0109	protoheme IX farnesyltransferase activity
A9R16_005765	COG4454	pyrroloquinoline quinone binding
A9R16_005800	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A9R16_005810	COG2205	protein histidine kinase activity
A9R16_005825	COG4566	intracellular signal transduction
A9R16_005875	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A9R16_005880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A9R16_005885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A9R16_005890	COG2154	pterin-4-alpha-carbinolamine dehydratase
A9R16_005895	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A9R16_005900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A9R16_005900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A9R16_005905	COG0802	atpase or kinase
A9R16_005910	COG0860	N-Acetylmuramoyl-L-alanine amidase
A9R16_005915	COG0531	amino acid
A9R16_005920	COG0675	Transposase, IS605 OrfB family
A9R16_005930	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A9R16_005940	COG0052	Belongs to the universal ribosomal protein uS2 family
A9R16_005945	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A9R16_005950	COG0528	UMP kinase activity
A9R16_005960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A9R16_005965	COG0575	Belongs to the CDS family
A9R16_005970	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A9R16_005985	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9R16_005990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A9R16_006000	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A9R16_006005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A9R16_006010	COG0587	DNA-directed DNA polymerase activity
A9R16_006015	COG0825	malonyl-CoA metabolic process
A9R16_006020	COG0037	tRNA processing
A9R16_006025	COG0504	CTP synthase activity
A9R16_006030	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A9R16_006035	COG0148	phosphopyruvate hydratase activity
A9R16_006060	COG1053	succinate dehydrogenase
A9R16_006065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A9R16_006080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A9R16_006095	COG2814	Major facilitator Superfamily
A9R16_006140	COG2814	Major facilitator Superfamily
A9R16_006145	COG0248	Ppx GppA phosphatase
A9R16_006165	COG3012	SEC-C Motif Domain Protein
A9R16_006200	COG1196	nuclear chromosome segregation
A9R16_006215	COG0515	serine threonine protein kinase
A9R16_006225	COG0069	glutamate synthase activity
A9R16_006235	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A9R16_006240	COG0174	glutamine synthetase
A9R16_006250	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A9R16_006250	COG0446	pyridine nucleotide-disulphide oxidoreductase
A9R16_006340	COG0463	Glycosyl transferase, family 2
A9R16_006355	COG2221	Nitrite and sulphite reductase 4Fe-4S
A9R16_006360	COG2221	Nitrite and sulphite reductase 4Fe-4S
A9R16_006365	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A9R16_006370	COG2923	Belongs to the DsrF TusC family
A9R16_006380	COG2920	part of a sulfur-relay system
A9R16_006415	COG1797	cobyrinic acid a,c-diamide synthase activity
A9R16_006420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9R16_006430	COG2197	response regulator
A9R16_006440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A9R16_006440	COG1648	precorrin-2 dehydrogenase activity
A9R16_006450	COG3152	Membrane
A9R16_006460	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A9R16_006465	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A9R16_006515	COG1403	HNH endonuclease
A9R16_006520	COG1278	Cold shock
A9R16_006530	COG2943	transferase activity, transferring hexosyl groups
A9R16_006530	COG3416	Protein conserved in bacteria
A9R16_006535	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A9R16_006555	COG0513	Belongs to the DEAD box helicase family
A9R16_006575	COG1968	undecaprenyl-diphosphatase activity
A9R16_006580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A9R16_006600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A9R16_006605	COG0481	GTPase activity
A9R16_006620	COG0571	ribonuclease III activity
A9R16_006625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A9R16_006630	COG1381	Involved in DNA repair and RecF pathway recombination
A9R16_006640	COG0736	holo-[acyl-carrier-protein] synthase activity
A9R16_006645	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A9R16_006650	COG0316	Belongs to the HesB IscA family
A9R16_006655	COG1181	Belongs to the D-alanine--D-alanine ligase family
A9R16_006680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A9R16_006710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A9R16_006720	COG0488	(ABC) transporter
A9R16_006725	COG0625	glutathione transferase activity
A9R16_006740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A9R16_006765	COG0475	glutathione-regulated potassium exporter activity
A9R16_006905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A9R16_006980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A9R16_007035	COG4584	PFAM Integrase catalytic
A9R16_007040	COG1484	DNA-dependent DNA replication
A9R16_007065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A9R16_007095	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A9R16_007105	COG0655	NAD(P)H dehydrogenase (quinone) activity
A9R16_007110	COG1733	regulation of RNA biosynthetic process
A9R16_007115	COG1322	Protein conserved in bacteria
A9R16_007120	COG0488	(ABC) transporter
A9R16_007125	COG0726	polysaccharide deacetylase
A9R16_007160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A9R16_007175	COG1064	alcohol dehydrogenase
A9R16_007180	COG2771	luxR family
A9R16_007210	COG2346	COG2346, Truncated hemoglobins
A9R16_007215	COG1959	2 iron, 2 sulfur cluster binding
A9R16_007245	COG1252	NADH dehydrogenase
A9R16_007255	COG1028	Short-chain dehydrogenase reductase Sdr
A9R16_007265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9R16_007270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A9R16_007270	COG0574	Belongs to the PEP-utilizing enzyme family
A9R16_007275	COG0280	phosphate acetyltransferase
A9R16_007300	COG1013	pyruvate-flavodoxin oxidoreductase activity
A9R16_007305	COG0674	pyruvate-flavodoxin oxidoreductase activity
A9R16_007330	COG1136	(ABC) transporter
A9R16_007345	COG0071	Belongs to the small heat shock protein (HSP20) family
A9R16_007360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A9R16_007370	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A9R16_007385	COG0457	Tetratricopeptide repeat
A9R16_007540	COG3609	addiction module antidote protein, CC2985 family
A9R16_007550	COG0675	Transposase, IS605 OrfB family
A9R16_007555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A9R16_007560	COG2129	metallophosphoesterase
A9R16_007590	COG3547	Transposase (IS116 IS110 IS902 family)
A9R16_007635	COG2274	protein secretion by the type I secretion system
A9R16_007670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9R16_007685	COG0438	transferase activity, transferring glycosyl groups
A9R16_007695	COG1110	DNA topoisomerase II activity
A9R16_007700	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A9R16_007715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A9R16_007720	COG2805	Type II/IV secretion system protein
A9R16_007745	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A9R16_007805	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A9R16_007840	COG0210	DNA helicase
A9R16_007975	COG0270	DNA (cytosine-5-)-methyltransferase activity
A9R16_008135	COG4974	Belongs to the 'phage' integrase family
A9R16_008245	COG0488	(ABC) transporter
A9R16_008250	COG0314	molybdopterin synthase activity
A9R16_008255	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A9R16_008265	COG0315	cyclic pyranopterin monophosphate synthase activity
A9R16_008270	COG3302	dmso reductase anchor subunit
A9R16_008275	COG0437	4 iron, 4 sulfur cluster binding
A9R16_008280	COG0243	molybdopterin cofactor binding
A9R16_008285	COG0179	Fumarylacetoacetate (FAA) hydrolase
A9R16_008290	COG2226	methyltransferase
A9R16_008305	COG1218	3'(2'),5'-bisphosphate nucleotidase
A9R16_008335	COG1716	ATPase activity
A9R16_008340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A9R16_008345	COG2171	N-acyltransferase activity
A9R16_008360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A9R16_008370	COG4591	ABC-type transport system involved in lipoprotein release permease component
A9R16_008375	COG1136	(ABC) transporter
A9R16_008380	COG0811	peptide transport
A9R16_008390	COG1132	(ABC) transporter
A9R16_008400	COG1663	tetraacyldisaccharide 4'-kinase activity
A9R16_008405	COG2835	tetraacyldisaccharide 4'-kinase activity
A9R16_008410	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A9R16_008420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A9R16_008425	COG1530	ribonuclease E activity
A9R16_008430	COG0564	pseudouridine synthase activity
A9R16_008450	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A9R16_008455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A9R16_008460	COG4942	peptidase
A9R16_008460	COG1388	LysM domain
A9R16_008475	COG0436	Aminotransferase
A9R16_008485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A9R16_008495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A9R16_008515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A9R16_008520	COG1376	ErfK ybiS ycfS ynhG family protein
A9R16_008525	COG1472	Belongs to the glycosyl hydrolase 3 family
A9R16_008530	COG1573	uracil-dna glycosylase
A9R16_008535	COG0322	excinuclease ABC activity
A9R16_008575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A9R16_008580	COG0589	response to stress
A9R16_008625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A9R16_008665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A9R16_008685	COG0508	dehydrogenase complex catalyzes the overall conversion of
A9R16_008715	COG2091	lysine biosynthetic process via aminoadipic acid
A9R16_008720	COG2771	luxR family
A9R16_008760	COG3344	reverse transcriptase
A9R16_008800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A9R16_008805	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A9R16_008810	COG2890	protein-(glutamine-N5) methyltransferase activity
A9R16_008830	COG0438	transferase activity, transferring glycosyl groups
A9R16_008835	COG1028	Short-chain dehydrogenase reductase Sdr
A9R16_008840	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A9R16_008845	COG0859	PFAM glycosyl transferase family 9
A9R16_008850	COG2192	nodulation
A9R16_008875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A9R16_008925	COG0084	hydrolase, TatD family'
A9R16_008940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A9R16_008945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A9R16_008955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A9R16_008960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A9R16_008965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A9R16_008970	COG1028	Short-chain dehydrogenase reductase Sdr
A9R16_008975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A9R16_008980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A9R16_008985	COG0416	fatty acid biosynthetic process
A9R16_008990	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A9R16_008995	COG1399	metal-binding, possibly nucleic acid-binding protein
A9R16_009005	COG0439	Biotin carboxylase
A9R16_009010	COG5016	pyruvate
A9R16_009010	COG0511	ligase activity, forming carbon-carbon bonds
A9R16_009015	COG0424	maF-like protein
A9R16_009020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A9R16_009030	COG0028	Belongs to the TPP enzyme family
A9R16_009035	COG4948	Mandelate Racemase Muconate Lactonizing
A9R16_009040	COG2116	formate transmembrane transporter activity
A9R16_009045	COG2855	membrane
A9R16_009050	COG1028	Short-chain dehydrogenase reductase Sdr
A9R16_009070	COG5001	Diguanylate cyclase
A9R16_009085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A9R16_009090	COG0305	Participates in initiation and elongation during chromosome replication
A9R16_009100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A9R16_009105	COG0360	Binds together with S18 to 16S ribosomal RNA
A9R16_009110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A9R16_009115	COG0557	exoribonuclease II activity
A9R16_009125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A9R16_009130	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A9R16_009140	COG0330	HflC and HflK could
A9R16_009165	COG0651	ATP synthesis coupled electron transport
A9R16_009180	COG0651	ATP synthesis coupled electron transport
A9R16_009185	COG0649	NAD binding
A9R16_009190	COG3260	NADH ubiquinone oxidoreductase 20
A9R16_009195	COG3300	MHYT domain
A9R16_009195	COG5001	Diguanylate cyclase
A9R16_009200	COG0768	penicillin binding
A9R16_009225	COG2801	Transposase and inactivated derivatives
A9R16_009230	COG2801	Transposase and inactivated derivatives
A9R16_009250	COG4555	ABC transporter
A9R16_009285	COG0477	Major facilitator Superfamily
A9R16_009295	COG0038	chloride channel
A9R16_009300	COG1047	Peptidyl-prolyl cis-trans
A9R16_009355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A9R16_009370	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A9R16_009385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A9R16_009390	COG0473	3-isopropylmalate dehydrogenase activity
A9R16_009395	COG0066	3-isopropylmalate dehydratase activity
A9R16_009400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A9R16_009410	COG2814	Major facilitator Superfamily
A9R16_009415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A9R16_009430	COG0542	response to heat
A9R16_009435	COG2095	MarC family integral membrane protein
A9R16_009455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A9R16_009465	COG0693	protein deglycase activity
A9R16_009490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A9R16_009495	COG0045	succinate-CoA ligase (ADP-forming) activity
A9R16_009515	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A9R16_009525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A9R16_009535	COG0542	response to heat
A9R16_009545	COG1278	Cold shock
A9R16_009580	COG0482	sulfurtransferase activity
A9R16_009600	COG0789	Transcriptional regulator
A9R16_009625	COG0129	dihydroxy-acid dehydratase activity
A9R16_009630	COG1187	pseudouridine synthase activity
A9R16_009635	COG0167	dihydroorotate dehydrogenase activity
A9R16_009660	COG2957	Belongs to the agmatine deiminase family
A9R16_009665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A9R16_009670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A9R16_009670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A9R16_009690	COG0586	Pfam SNARE associated Golgi protein
A9R16_009700	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A9R16_009700	COG1605	Chorismate mutase
A9R16_009705	COG0372	Belongs to the citrate synthase family
A9R16_009710	COG2027	D-alanyl-D-alanine carboxypeptidase
A9R16_009715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A9R16_009715	COG0561	phosphatase activity
A9R16_009720	COG0668	transmembrane transport
A9R16_009725	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A9R16_009730	COG0210	DNA helicase
A9R16_009740	COG5001	Diguanylate cyclase
A9R16_009745	COG1752	Esterase of the alpha-beta hydrolase superfamily
A9R16_009760	COG0335	large ribosomal subunit rRNA binding
A9R16_009765	COG0336	Belongs to the RNA methyltransferase TrmD family
A9R16_009770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A9R16_009775	COG0228	four-way junction DNA binding
A9R16_009790	COG1187	pseudouridine synthase activity
A9R16_009795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A9R16_009800	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A9R16_009805	COG0180	Tryptophanyl-tRNA synthetase
A9R16_009810	COG1994	Peptidase M50
A9R16_009815	COG0009	L-threonylcarbamoyladenylate synthase
A9R16_009820	COG0613	PHP domain protein
A9R16_009830	COG2350	Protein conserved in bacteria
A9R16_009840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A9R16_009845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A9R16_009850	COG3115	cell septum assembly
A9R16_009855	COG1196	nuclear chromosome segregation
A9R16_009860	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A9R16_009865	COG1070	Carbohydrate kinase
A9R16_009885	COG1538	Outer membrane efflux protein
A9R16_009890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9R16_009895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9R16_009910	COG0494	nUDIX hydrolase
A9R16_009920	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A9R16_009925	COG3023	N-Acetylmuramoyl-L-alanine amidase
A9R16_009935	COG1280	lysine exporter protein (LysE YggA)
A9R16_009945	COG2733	membrane
A9R16_009950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A9R16_009955	COG0247	lactate metabolic process
A9R16_009960	COG0529	Catalyzes the synthesis of activated sulfate
A9R16_009995	COG1566	PFAM secretion protein HlyD family protein
A9R16_010025	COG2217	Heavy metal translocating P-type atpase
A9R16_010040	COG1595	DNA-templated transcription, initiation
A9R16_010070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A9R16_010070	COG0678	peroxiredoxin activity
A9R16_010080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A9R16_010085	COG2719	SpoVR family
A9R16_010090	COG2718	Belongs to the UPF0229 family
A9R16_010095	COG2766	serine protein kinase
A9R16_010100	COG2223	nitrite transmembrane transporter activity
A9R16_010125	COG0393	Putative heavy-metal-binding
A9R16_010140	COG1741	Belongs to the pirin family
A9R16_010150	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A9R16_010165	COG3002	Belongs to the UPF0753 family
A9R16_010175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A9R16_010200	COG2193	ferroxidase activity
A9R16_010205	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A9R16_010210	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A9R16_010215	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A9R16_010245	COG1850	ribulose-bisphosphate carboxylase activity
A9R16_010255	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A9R16_010275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A9R16_010280	COG1923	regulation of RNA biosynthetic process
A9R16_010285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A9R16_010290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A9R16_010295	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A9R16_010320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A9R16_010385	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A9R16_010400	COG3158	transport of potassium into the cell
A9R16_010405	COG3158	transport of potassium into the cell
A9R16_010425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A9R16_010430	COG0109	protoheme IX farnesyltransferase activity
A9R16_010445	COG1845	cytochrome c oxidase, subunit III
A9R16_010455	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A9R16_010470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A9R16_010490	COG0366	Alpha amylase catalytic
A9R16_010495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A9R16_010500	COG0058	SHG alpha-glucan phosphorylase activity
A9R16_010515	COG2204	response regulator
A9R16_010540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A9R16_010545	COG0166	Belongs to the GPI family
A9R16_010550	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A9R16_010555	COG0837	glucose binding
A9R16_010565	COG0297	glycogen (starch) synthase activity
A9R16_010575	COG0670	Belongs to the BI1 family
A9R16_010585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A9R16_010590	COG2146	nitrite reductase [NAD(P)H] activity
A9R16_010595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A9R16_010610	COG2814	Major facilitator Superfamily
A9R16_010620	COG0328	RNA-DNA hybrid ribonuclease activity
A9R16_010625	COG2226	methyltransferase
A9R16_010630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9R16_010635	COG0741	lytic transglycosylase activity
A9R16_010635	COG1388	LysM domain
A9R16_010645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A9R16_010660	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A9R16_010675	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A9R16_010685	COG0740	serine-type endopeptidase activity
A9R16_010690	COG0544	peptidyl-prolyl cis-trans isomerase activity
A9R16_010700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A9R16_010705	COG0326	Molecular chaperone. Has ATPase activity
A9R16_010730	COG0859	PFAM glycosyl transferase family 9
A9R16_010765	COG0438	transferase activity, transferring glycosyl groups
A9R16_010775	COG2200	EAL domain
A9R16_010775	COG2199	diguanylate cyclase activity
A9R16_010785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A9R16_010790	COG0004	ammonium transporteR
A9R16_010800	COG0625	glutathione transferase activity
A9R16_010805	COG0675	Transposase, IS605 OrfB family
A9R16_010820	COG0776	regulation of translation
A9R16_010825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9R16_010825	COG0072	phenylalanine-tRNA ligase activity
A9R16_010830	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A9R16_010835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A9R16_010840	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A9R16_010845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A9R16_010850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A9R16_010860	COG0556	nucleotide-excision repair
A9R16_010865	COG0436	Aminotransferase
A9R16_010890	COG2084	Dehydrogenase
A9R16_010895	COG3180	Ammonia monooxygenase
A9R16_011015	COG1845	cytochrome c oxidase, subunit III
A9R16_011020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A9R16_011025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A9R16_011030	COG0625	glutathione transferase activity
A9R16_011075	COG1657	PFAM Prenyltransferase squalene oxidase
A9R16_011095	COG3394	polysaccharide catabolic process
A9R16_011110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9R16_011115	COG2853	Lipoprotein
A9R16_011125	COG1215	transferase activity, transferring glycosyl groups
A9R16_011130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A9R16_011135	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A9R16_011150	COG0386	Belongs to the glutathione peroxidase family
A9R16_011155	COG1902	pentaerythritol trinitrate reductase activity
A9R16_011175	COG0675	Transposase, IS605 OrfB family
A9R16_011195	COG0330	HflC and HflK could
A9R16_011210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A9R16_011225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A9R16_011255	COG2203	Gaf domain
A9R16_011255	COG2199	diguanylate cyclase activity
A9R16_011285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A9R16_011290	COG1047	Peptidyl-prolyl cis-trans
A9R16_011300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A9R16_011305	COG0196	riboflavin kinase activity
A9R16_011320	COG0268	Binds directly to 16S ribosomal RNA
A9R16_011325	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A9R16_011330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A9R16_011335	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A9R16_011340	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A9R16_011345	COG0142	geranyltranstransferase activity
A9R16_011415	COG0543	2 iron, 2 sulfur cluster binding
A9R16_011415	COG0493	'glutamate synthase
A9R16_011420	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A9R16_011425	COG0730	response to heat
A9R16_011435	COG0251	oxidation-reduction process
A9R16_011440	COG1126	abc transporter atp-binding protein
A9R16_011505	COG2165	general secretion pathway protein
A9R16_011540	COG1064	alcohol dehydrogenase
A9R16_011545	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A9R16_011555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A9R16_011560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A9R16_011565	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A9R16_011585	COG1538	Outer membrane efflux protein
A9R16_011595	COG1131	(ABC) transporter
A9R16_011600	COG0842	Transport permease protein
A9R16_011605	COG0842	Transport permease protein
A9R16_011670	COG3852	Histidine kinase
A9R16_011725	COG3387	PFAM Glycoside hydrolase 15-related
A9R16_011735	COG0730	response to heat
A9R16_011745	COG1845	cytochrome c oxidase, subunit III
A9R16_011750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A9R16_011755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A9R16_011765	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A9R16_011770	COG0402	S-adenosylhomocysteine deaminase activity
A9R16_011780	COG0546	phosphoglycolate phosphatase activity
A9R16_011785	COG0720	synthase
A9R16_011790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A9R16_011795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A9R16_011800	COG0586	Pfam SNARE associated Golgi protein
A9R16_011805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A9R16_011810	COG0429	hydrolase of the alpha beta-hydrolase fold
A9R16_011825	COG1185	polyribonucleotide nucleotidyltransferase activity
A9R16_011830	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A9R16_011840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A9R16_011845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A9R16_011850	COG0195	Participates in both transcription termination and antitermination
A9R16_011850	COG2251	uridine kinase activity
A9R16_011855	COG0779	Required for maturation of 30S ribosomal subunits
A9R16_011910	COG1007	ATP synthesis coupled electron transport
A9R16_011925	COG0713	ATP synthesis coupled electron transport
A9R16_011935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9R16_011940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A9R16_011945	COG1034	ATP synthesis coupled electron transport
A9R16_011955	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A9R16_011960	COG0649	NAD binding
A9R16_011965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9R16_011970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9R16_011975	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A9R16_011990	COG0149	triose-phosphate isomerase activity
A9R16_011995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A9R16_012000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A9R16_012010	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A9R16_012020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A9R16_012025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A9R16_012030	COG0505	Belongs to the CarA family
A9R16_012045	COG0484	heat shock protein binding
A9R16_012050	COG0443	Heat shock 70 kDa protein
A9R16_012055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A9R16_012060	COG1420	regulation of RNA biosynthetic process
A9R16_012065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A9R16_012070	COG0497	DNA recombination
A9R16_012075	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A9R16_012075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A9R16_012085	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A9R16_012095	COG2867	negative regulation of translational initiation
A9R16_012100	COG0733	neurotransmitter:sodium symporter activity
A9R16_012105	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A9R16_012175	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A9R16_012185	COG1722	exodeoxyribonuclease VII activity
A9R16_012190	COG0142	geranyltranstransferase activity
A9R16_012195	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A9R16_012200	COG1469	GTP cyclohydrolase I activity
A9R16_012210	COG1566	PFAM secretion protein HlyD family protein
A9R16_012220	COG2814	Major facilitator Superfamily
A9R16_012225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A9R16_012230	COG1940	carbohydrate kinase activity
A9R16_012240	COG0675	Transposase, IS605 OrfB family
A9R16_012245	COG0442	prolyl-tRNA aminoacylation
A9R16_012260	COG1254	Belongs to the acylphosphatase family
A9R16_012270	COG1509	lysine 2,3-aminomutase activity
A9R16_012280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A9R16_012290	COG1902	pentaerythritol trinitrate reductase activity
A9R16_012295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9R16_012295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9R16_012305	COG0477	Major facilitator Superfamily
A9R16_012315	COG2201	protein-glutamate methylesterase activity
A9R16_012345	COG0500	methyltransferase
A9R16_012355	COG1027	Aspartate ammonia-lyase
A9R16_012365	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A9R16_012370	COG0628	permease
A9R16_012375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A9R16_012380	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A9R16_012385	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A9R16_012390	COG1595	DNA-templated transcription, initiation
A9R16_012425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A9R16_012435	COG3383	formate dehydrogenase (NAD+) activity
A9R16_012445	COG2003	Belongs to the UPF0758 family
A9R16_012450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A9R16_012455	COG0756	dUTP diphosphatase activity
A9R16_012495	COG0717	Belongs to the dCTP deaminase family
A9R16_012515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9R16_012515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9R16_012570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A9R16_012575	COG2878	Part of a membrane complex involved in electron transport
A9R16_012580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A9R16_012610	COG0137	argininosuccinate synthase activity
A9R16_012615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9R16_012620	COG0508	dehydrogenase complex catalyzes the overall conversion of
A9R16_012620	COG0022	dehydrogenase e1 component
A9R16_012625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A9R16_012630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A9R16_012635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A9R16_012640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A9R16_012650	COG0488	(ABC) transporter
A9R16_012655	COG5265	(ABC) transporter
A9R16_012685	COG0509	glycine decarboxylation via glycine cleavage system
A9R16_012700	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A9R16_012700	COG0047	phosphoribosylformylglycinamidine synthase activity
A9R16_012705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A9R16_012715	COG2198	Histidine kinase
A9R16_012715	COG2205	protein histidine kinase activity
A9R16_012715	COG0784	Response regulator, receiver
A9R16_012720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A9R16_012725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A9R16_012730	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A9R16_012770	COG1592	Rubrerythrin
A9R16_012780	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A9R16_012785	COG0237	dephospho-CoA kinase activity
A9R16_012810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A9R16_012825	COG2204	response regulator
A9R16_012850	COG0494	nUDIX hydrolase
A9R16_012855	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A9R16_012860	COG0653	protein targeting
A9R16_012865	COG0739	heme binding
A9R16_012875	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A9R16_012880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A9R16_012895	COG1181	Belongs to the D-alanine--D-alanine ligase family
A9R16_012900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A9R16_012905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A9R16_012910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A9R16_012915	COG0772	Belongs to the SEDS family
A9R16_012920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A9R16_012925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A9R16_012930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A9R16_012935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A9R16_012950	COG0275	rRNA processing
A9R16_012955	COG2001	Belongs to the MraZ family
A9R16_012960	COG0778	Nitroreductase
A9R16_012965	COG1733	regulation of RNA biosynthetic process
A9R16_012985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A9R16_012990	COG3300	MHYT domain
A9R16_012990	COG5001	Diguanylate cyclase
A9R16_013005	COG0148	phosphopyruvate hydratase activity
A9R16_013010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A9R16_013015	COG2857	Cytochrome c1
A9R16_013020	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A9R16_013025	COG0723	plastoquinol--plastocyanin reductase activity
A9R16_013030	COG1028	Short-chain dehydrogenase reductase Sdr
A9R16_013050	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A9R16_013060	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A9R16_013065	COG0277	FAD linked oxidase domain protein
A9R16_013090	COG0625	glutathione transferase activity
A9R16_013105	COG0438	transferase activity, transferring glycosyl groups
A9R16_013110	COG2814	Major facilitator Superfamily
A9R16_013120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A9R16_013125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A9R16_013135	COG0140	phosphoribosyl-ATP diphosphatase activity
A9R16_013145	COG0107	imidazoleglycerol-phosphate synthase activity
A9R16_013150	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A9R16_013155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A9R16_013160	COG0131	Imidazoleglycerol-phosphate dehydratase
A9R16_013165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A9R16_013170	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A9R16_013175	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A9R16_013180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A9R16_013185	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A9R16_013195	COG0842	Transport permease protein
A9R16_013200	COG1131	(ABC) transporter
A9R16_013215	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A9R16_013220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A9R16_013225	COG1127	ABC transporter
A9R16_013260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A9R16_013270	COG1518	maintenance of DNA repeat elements
A9R16_013315	COG1131	(ABC) transporter
A9R16_013330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A9R16_013345	COG1137	ATPase activity
A9R16_013360	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A9R16_013365	COG1660	Displays ATPase and GTPase activities
A9R16_013375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9R16_013380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A9R16_013390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9R16_013400	COG0312	modulator of DNA gyrase
A9R16_013405	COG0312	modulator of DNA gyrase
A9R16_013410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A9R16_013425	COG0424	maF-like protein
A9R16_013430	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A9R16_013440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A9R16_013445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A9R16_013460	COG0495	leucyl-tRNA aminoacylation
A9R16_013465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9R16_013475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A9R16_013500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9R16_013510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9R16_013515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A9R16_013520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A9R16_013520	COG2813	Specifically methylates the guanine in position
A9R16_013525	COG2814	Major facilitator Superfamily
A9R16_013530	COG0708	Exodeoxyribonuclease III
A9R16_013540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A9R16_013555	COG2046	Belongs to the sulfate adenylyltransferase family
A9R16_013600	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
A9R16_013605	COG5420	small protein containing a coiled-coil domain
A9R16_013620	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A9R16_013625	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A9R16_013635	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A9R16_013640	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A9R16_013645	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
A9R16_013660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A9R16_013670	COG5554	nitrogen fixation
A9R16_013675	COG1104	cysteine desulfurase activity
A9R16_013680	COG5554	nitrogen fixation
A9R16_013690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A9R16_013700	COG0316	Belongs to the HesB IscA family
A9R16_013705	COG3300	MHYT domain
A9R16_013705	COG5001	Diguanylate cyclase
A9R16_013720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A9R16_013740	COG0822	iron-sulfur transferase activity
A9R16_013855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A9R16_013860	COG0009	L-threonylcarbamoyladenylate synthase
A9R16_013865	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A9R16_013870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A9R16_013875	COG0129	dihydroxy-acid dehydratase activity
A9R16_013880	COG0418	dihydroorotase activity
A9R16_013890	COG3002	Belongs to the UPF0753 family
A9R16_013895	COG0191	fructose-bisphosphate aldolase activity
A9R16_013900	COG0583	DNA-binding transcription factor activity
A9R16_013930	COG5001	Diguanylate cyclase
A9R16_013930	COG3300	MHYT domain
A9R16_013950	COG3002	Belongs to the UPF0753 family
A9R16_013955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A9R16_014035	COG5001	Diguanylate cyclase
A9R16_014055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A9R16_014060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A9R16_014070	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A9R16_014090	COG0175	sulfate reduction
A9R16_014100	COG0583	DNA-binding transcription factor activity
A9R16_014110	COG2857	Cytochrome c1
A9R16_014115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A9R16_014120	COG0723	plastoquinol--plastocyanin reductase activity
A9R16_014125	COG1028	Short-chain dehydrogenase reductase Sdr
A9R16_014160	COG0601	transmembrane transport
A9R16_014170	COG0444	Belongs to the ABC transporter superfamily
A9R16_014175	COG4608	Belongs to the ABC transporter superfamily
A9R16_014200	COG3177	Filamentation induced by cAMP protein fic
A9R16_014225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A9R16_014240	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A9R16_014250	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A9R16_014255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A9R16_014265	COG1028	Short-chain dehydrogenase reductase Sdr
A9R16_014285	COG0617	tRNA 3'-terminal CCA addition
A9R16_014305	COG1012	belongs to the aldehyde dehydrogenase family
A9R16_014320	COG1331	Highly conserved protein containing a thioredoxin domain
A9R16_014325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9R16_014335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A9R16_014340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A9R16_014350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A9R16_014360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A9R16_014370	COG3093	addiction module antidote protein HigA
A9R16_014425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A9R16_014460	COG0339	signal peptide processing
A9R16_014465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A9R16_014475	COG0625	glutathione transferase activity
A9R16_014480	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A9R16_014485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A9R16_014495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A9R16_014505	COG0194	GDP metabolic process
A9R16_014510	COG1561	YicC-like family, N-terminal region
A9R16_014515	COG0515	serine threonine protein kinase
A9R16_014515	COG2815	serine threonine protein kinase
A9R16_014520	COG0631	protein serine/threonine phosphatase activity
A9R16_014525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A9R16_014530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A9R16_014535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A9R16_014540	COG1981	membrane
A9R16_014570	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A9R16_014575	COG0830	nickel cation binding
A9R16_014580	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A9R16_014585	COG0804	urea catabolic process
A9R16_014590	COG0832	Belongs to the urease beta subunit family
A9R16_014595	COG0831	urea catabolic process
A9R16_014600	COG0829	nickel cation binding
A9R16_014610	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9R16_014630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A9R16_014635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A9R16_014640	COG0493	'glutamate synthase
A9R16_014645	COG0070	glutamate synthase
A9R16_014645	COG0069	glutamate synthase activity
A9R16_014645	COG0067	glutamate synthase
A9R16_014690	COG0018	arginyl-trna synthetase
A9R16_014700	COG2897	thiosulfate sulfurtransferase activity
A9R16_014705	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
A9R16_014710	COG1116	anion transmembrane transporter activity
A9R16_014715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A9R16_014720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A9R16_014720	COG1116	anion transmembrane transporter activity
A9R16_014740	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A9R16_014750	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A9R16_014755	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A9R16_014755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9R16_014760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9R16_014765	COG0675	Transposase, IS605 OrfB family
A9R16_014775	COG0330	HflC and HflK could
A9R16_014805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9R16_014820	COG1846	Transcriptional regulator
A9R16_014840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9R16_014845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A9R16_014855	COG0625	glutathione transferase activity
A9R16_014870	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A9R16_014870	COG1618	nucleotide phosphatase activity, acting on free nucleotides
A9R16_014875	COG0521	Mo-molybdopterin cofactor biosynthetic process
A9R16_014880	COG0303	'Molybdopterin
A9R16_014885	COG0746	molybdenum cofactor guanylyltransferase activity
A9R16_014915	COG0243	molybdopterin cofactor binding
A9R16_014925	COG2223	nitrite transmembrane transporter activity
A9R16_014945	COG0004	ammonium transporteR
A9R16_014950	COG0347	Belongs to the P(II) protein family
A9R16_014955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A9R16_014960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A9R16_015000	COG1484	DNA-dependent DNA replication
A9R16_015005	COG4584	PFAM Integrase catalytic
A9R16_015060	COG1074	ATP-dependent DNA helicase activity
A9R16_015065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A9R16_015090	COG3387	PFAM Glycoside hydrolase 15-related
A9R16_015095	COG0254	rRNA binding
A9R16_015100	COG0281	malic enzyme
A9R16_015110	COG2890	protein-(glutamine-N5) methyltransferase activity
A9R16_015130	COG0183	Belongs to the thiolase family
A9R16_015135	COG1960	acyl-CoA dehydrogenase activity
A9R16_015155	COG0135	phosphoribosylanthranilate isomerase activity
A9R16_015195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A9R16_015205	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A9R16_015210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A9R16_015220	COG0675	Transposase, IS605 OrfB family
A9R16_015260	COG1487	ribonuclease activity
A9R16_015275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9R16_015275	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9R16_015280	COG1611	Belongs to the LOG family
A9R16_015285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A9R16_015300	COG0210	DNA helicase
A9R16_015320	COG1842	Phage shock protein A
A9R16_015380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A9R16_015395	COG0543	2 iron, 2 sulfur cluster binding
A9R16_015395	COG0493	'glutamate synthase
A9R16_015420	COG2188	Transcriptional regulator
A9R16_015425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A9R16_015430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A9R16_015435	COG1047	Peptidyl-prolyl cis-trans
A9R16_015440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A9R16_015445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A9R16_015450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A9R16_015455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A9R16_015460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A9R16_015465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A9R16_015470	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A9R16_015475	COG0356	it plays a direct role in the translocation of protons across the membrane
A9R16_015490	COG1475	DNA binding
A9R16_015495	COG1192	Involved in chromosome partitioning
A9R16_015500	COG0357	Ribosomal RNA small subunit methyltransferase G
A9R16_015505	COG0445	tRNA wobble uridine modification
A9R16_015535	COG0714	Associated with various cellular activities
A9R16_015550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A9R16_015555	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A9R16_015560	COG0706	membrane insertase activity
A9R16_015565	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A9R16_015570	COG0594	ribonuclease P activity
A9R16_015575	COG0230	Belongs to the bacterial ribosomal protein bL34 family