locus-tag	class	description
ASAC_0006	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
ASAC_0020	ENOG4105CIG	ABC transporter
ASAC_0022	ENOG4107QRT	dEAD DEAH box helicase
ASAC_0026	ENOG4105CHU	acetyl-coa acetyltransferase
ASAC_0028	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
ASAC_0029	ENOG4105EIE	fructose-bisphosphate aldolase
ASAC_0030	ENOG4105EDK	PfkB domain protein
ASAC_0031	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
ASAC_0041	ENOG4105CPC	Aldo Keto reductase
ASAC_0044	ENOG4107QR9	Iron-sulfur cluster binding protein
ASAC_0048	ENOG4108YZ4	nudix hydrolase
ASAC_0049	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
ASAC_0053	ENOG4107RIQ	Sulfate adenylate transferase
ASAC_0055	ENOG4107T1U	Catalyzes the synthesis of activated sulfate (By similarity)
ASAC_0059	ENOG4107TYG	Oxidoreductase domain-containing protein
ASAC_0061	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
ASAC_0064	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
ASAC_0068	ENOG4105ESV	Glycosyl transferase, family 4
ASAC_0072	ENOG4105PW4	Sugar fermentation stimulation protein homolog
ASAC_0077	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
ASAC_0078	ENOG4107R51	Glycosyl transferase, family 2
ASAC_0080	ENOG4105CKK	Glycosyl transferase, family 2
ASAC_0082	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ASAC_0085	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
ASAC_0086	ENOG4105EG2	ABC transporter, permease
ASAC_0091	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
ASAC_0092	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
ASAC_0094	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASAC_0096	ENOG4105EJ5	oxidoreductase gamma subunit
ASAC_0097	ENOG4105WGB	oxidoreductase, delta subunit
ASAC_0098	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
ASAC_0099	ENOG4105DDK	oxidoreductase, beta subunit
ASAC_0100	ENOG4107QTZ	amino acid
ASAC_0101	ENOG4105CRK	lysyL-tRNA synthetase
ASAC_0103	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
ASAC_0104	ENOG4105D52	delta-aminolevulinic acid dehydratase
ASAC_0106	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
ASAC_0107	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
ASAC_0108	ENOG4108V1U	phospholipid-binding protein
ASAC_0111	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
ASAC_0116	ENOG4105CEU	Arginine dihydrolase
ASAC_0117	ENOG4108I5U	Uridine phosphorylase
ASAC_0119	ENOG4105C5I	Dehydrogenase
ASAC_0120	ENOG4105DF6	Fe-S oxidoreductase
ASAC_0129	ENOG4105D0M	Protease HtpX homolog
ASAC_0130	ENOG4105CQ2	DNA polymerase
ASAC_0137	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
ASAC_0138	ENOG4105CYW	agmatinase
ASAC_0140	ENOG4108ZJT	translation initiation factor, Sui1
ASAC_0141	ENOG4108K7V	UPF0284 protein
ASAC_0144	ENOG4105CIH	Imidazole acetol-phosphate transaminase
ASAC_0146	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
ASAC_0151	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
ASAC_0155	ENOG4105C1G	acyl-Coa dehydrogenase
ASAC_0159	ENOG41081FY	multiple antibiotic resistance (MarC)-related
ASAC_0175	ENOG4105F4P	)-transporter
ASAC_0179	ENOG4108ZAF	Molybdopterin
ASAC_0181	ENOG4107QRT	dEAD DEAH box helicase
ASAC_0185	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
ASAC_0187	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
ASAC_0188	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
ASAC_0192	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
ASAC_0195	ENOG4105CKK	Glycosyl transferase, family 2
ASAC_0203	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
ASAC_0213	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
ASAC_0217	ENOG4108EHY	type IV secretion system
ASAC_0219	ENOG4105E0R	Deoxyhypusine synthase
ASAC_0223	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
ASAC_0225	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ASAC_0228	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
ASAC_0231	ENOG4107FF9	50s ribosomal protein l29
ASAC_0232	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
ASAC_0233	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
ASAC_0234	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
ASAC_0236	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
ASAC_0241	ENOG4105C8N	cysteinyl-tRNA synthetase
ASAC_0244	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
ASAC_0258	ENOG4105C3M	thioredoxin reductase
ASAC_0259	ENOG4105DRR	Transcriptional regulator, GntR family
ASAC_0264	ENOG4105C10	Electron transfer flavoprotein
ASAC_0265	ENOG4105BZJ	Electron transfer flavoprotein
ASAC_0266	ENOG41090P5	ferredoxin-like protein
ASAC_0267	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
ASAC_0269	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
ASAC_0270	ENOG4108SDH	ABC, transporter
ASAC_0271	ENOG4105CJ1	ABC, transporter
ASAC_0274	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
ASAC_0275	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
ASAC_0281	ENOG4108Z4T	Peptidase M50
ASAC_0285	ENOG4105C22	threonyL-tRNA synthetase
ASAC_0288	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
ASAC_0291	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
ASAC_0295	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ASAC_0305	ENOG4105DBV	ornithine carbamoyltransferase
ASAC_0308	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
ASAC_0312	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
ASAC_0314	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
ASAC_0315	ENOG4108MDK	Dehydrogenase
ASAC_0316	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
ASAC_0317	ENOG4105CY0	Metallo-Beta-Lactamase
ASAC_0322	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
ASAC_0323	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
ASAC_0327	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
ASAC_0331	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
ASAC_0334	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
ASAC_0337	ENOG4107TIA	phenylalanyl-tRNA synthetase (beta subunit)
ASAC_0338	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
ASAC_0340	ENOG4108I5U	Uridine phosphorylase
ASAC_0345	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
ASAC_0347	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
ASAC_0348	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
ASAC_0352	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASAC_0353	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASAC_0359	ENOG4108JPW	Aminotransferase
ASAC_0363	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
ASAC_0365	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
ASAC_0366	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
ASAC_0367	ENOG4105CMR	udp-glucose 4-epimerase
ASAC_0369	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
ASAC_0370	ENOG4108I5D	sulfate abc transporter
ASAC_0374	ENOG4105D65	subunit l
ASAC_0379	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
ASAC_0380	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ASAC_0381	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ASAC_0382	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ASAC_0386	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
ASAC_0389	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
ASAC_0391	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
ASAC_0392	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
ASAC_0394	ENOG4105DHP	deoxycytidine triphosphate deaminase
ASAC_0396	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
ASAC_0398	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
ASAC_0400	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
ASAC_0402	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
ASAC_0406	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ASAC_0410	ENOG4105C5S	asparaginyl-tRNA synthetase
ASAC_0416	ENOG4107WUB	V-type ATPase 116 kDa subunit
ASAC_0417	ENOG4105KXQ	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
ASAC_0419	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
ASAC_0420	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
ASAC_0428	ENOG4105C9U	ATP-dependent DNA helicase RecQ
ASAC_0430	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
ASAC_0434	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
ASAC_0437	ENOG4107QRT	dEAD DEAH box helicase
ASAC_0438	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
ASAC_0443	ENOG4105E8R	UPF0173 metal-dependent hydrolase
ASAC_0444	ENOG4108JJB	ABC transporter
ASAC_0445	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
ASAC_0446	ENOG41080HJ	6-phospho 3-hexuloisomerase
ASAC_0450	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
ASAC_0451	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
ASAC_0458	ENOG4105C5S	asparaginyl-tRNA synthetase
ASAC_0461	ENOG4108ZKT	aldose 1-epimerase
ASAC_0463	ENOG4107ZT3	family UPF0126
ASAC_0466	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
ASAC_0467	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
ASAC_0476	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
ASAC_0478	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
ASAC_0479	ENOG4105VG1	fes assembly suf system protein
ASAC_0481	ENOG4107TH8	cina domain protein
ASAC_0483	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
ASAC_0485	ENOG4105ECY	inositol monophosphatase
ASAC_0493	ENOG4105ETU	transcriptional activator (TenA
ASAC_0498	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
ASAC_0499	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
ASAC_0500	ENOG4105EHG	Permease protein
ASAC_0501	ENOG4108HUF	Transporter
ASAC_0502	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
ASAC_0505	ENOG4105FCD	Major Facilitator
ASAC_0511	ENOG4105CEY	Amp-dependent synthetase and ligase
ASAC_0515	ENOG4105KST	dependent repressor
ASAC_0516	ENOG4105MRR	Transcriptional regulator (By similarity)
ASAC_0521	ENOG4105K59	histidine triad (HIT) protein
ASAC_0522	ENOG4105C0B	DNA polymerase III (alpha subunit)
ASAC_0524	ENOG4107XCH	Cyclase family
ASAC_0530	ENOG4108K16	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
ASAC_0531	ENOG4105CNW	domain protein
ASAC_0533	ENOG4105C22	threonyL-tRNA synthetase
ASAC_0537	ENOG4105C9Q	fumarate hydratase class II
ASAC_0539	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
ASAC_0544	ENOG4105CY0	Metallo-Beta-Lactamase
ASAC_0546	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
ASAC_0548	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
ASAC_0549	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
ASAC_0551	ENOG4105C9U	ATP-dependent DNA helicase RecQ
ASAC_0554	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
ASAC_0557	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
ASAC_0560	ENOG4105F73	Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
ASAC_0567	ENOG4105ERH	Fumarylacetoacetate hydrolase
ASAC_0568	ENOG4107SET	aldo keto reductase
ASAC_0569	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
ASAC_0572	ENOG4105C84	Histidine ammonia-lyase
ASAC_0573	ENOG4108903	Formimidoylglutamase
ASAC_0576	ENOG4105EYF	MMPL domain protein
ASAC_0579	ENOG4105C9B	Cysteine desulfurase
ASAC_0581	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ASAC_0582	ENOG4105C1G	acyl-Coa dehydrogenase
ASAC_0584	ENOG4105D3R	alkyl hydroperoxide reductase
ASAC_0588	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
ASAC_0589	ENOG4105D9P	serine threonine protein kinase
ASAC_0590	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
ASAC_0597	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
ASAC_0598	ENOG4106HK8	GPR1 FUN34 yaaH family protein
ASAC_0602	ENOG4105C57	major facilitator superfamily
ASAC_0615	ENOG4107QIZ	NADH dehydrogenase
ASAC_0616	ENOG4105CHM	Aminotransferase
ASAC_0618	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
ASAC_0623	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ASAC_0630	ENOG4105CB2	alcohol dehydrogenase
ASAC_0632	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
ASAC_0634	ENOG4107U7N	hydantoinase B oxoprolinase
ASAC_0637	ENOG4108SHN	Glycosyl transferase, family 2
ASAC_0655	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
ASAC_0658	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
ASAC_0660	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
ASAC_0661	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
ASAC_0662	ENOG4108SHN	Glycosyl transferase, family 2
ASAC_0666	ENOG4108TJN	glycosyl transferase group 1
ASAC_0667	ENOG4108SHN	Glycosyl transferase, family 2
ASAC_0678	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
ASAC_0680	ENOG4108SHN	Glycosyl transferase, family 2
ASAC_0681	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
ASAC_0684	ENOG4108SHN	Glycosyl transferase, family 2
ASAC_0698	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
ASAC_0700	ENOG4108JB8	alcohol dehydrogenase
ASAC_0701	ENOG41083I7	UPF0145 protein
ASAC_0704	ENOG4105CI2	imidazolone-5-propionate hydrolase
ASAC_0705	ENOG4105BZ1	(ABC) transporter
ASAC_0708	ENOG4105HF9	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
ASAC_0713	ENOG4108RVA	ribokinase
ASAC_0728	ENOG4105CSA	Coproporphyrinogen iii oxidase
ASAC_0739	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
ASAC_0742	ENOG4105CTD	carboxy-peptidase
ASAC_0743	ENOG4105C26	Dehydrogenase
ASAC_0747	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
ASAC_0752	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
ASAC_0759	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
ASAC_0762	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
ASAC_0764	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
ASAC_0765	ENOG4105D06	uba thif-type nad fad binding protein
ASAC_0773	ENOG4107QTZ	amino acid
ASAC_0774	ENOG4105CKK	Glycosyl transferase, family 2
ASAC_0779	ENOG4108WBT	adenosyltransferase
ASAC_0780	ENOG4105C26	Dehydrogenase
ASAC_0782	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
ASAC_0783	ENOG4107TSN	permease
ASAC_0786	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
ASAC_0788	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
ASAC_0789	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
ASAC_0791	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
ASAC_0792	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
ASAC_0793	ENOG4105C6T	cysteine synthase
ASAC_0794	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
ASAC_0795	ENOG41076QQ	Glycosyl transferase, family 2
ASAC_0797	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
ASAC_0799	ENOG4105C32	Amino acid ABC transporter (Permease)
ASAC_0801	ENOG4108IV0	ABC, transporter
ASAC_0802	ENOG4105C0Z	ABC transporter
ASAC_0803	ENOG4105D44	asparaginase
ASAC_0806	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ASAC_0807	ENOG4105C3U	ABC transporter
ASAC_0808	ENOG4108JQ7	(ABC) transporter
ASAC_0812	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
ASAC_0816	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
ASAC_0817	ENOG4108HMX	isocitrate dehydrogenase (NADP)
ASAC_0823	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
ASAC_0827	ENOG41080HI	glycine oxidase
ASAC_0828	ENOG4105CHM	Aminotransferase
ASAC_0830	ENOG4105VF7	tolerance protein
ASAC_0832	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
ASAC_0833	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
ASAC_0835	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
ASAC_0840	ENOG4105CHR	reductase
ASAC_0843	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
ASAC_0850	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
ASAC_0855	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
ASAC_0858	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
ASAC_0859	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
ASAC_0860	ENOG4105CPN	adenine deaminase
ASAC_0874	ENOG4105DQU	oxidoreductase, subunit beta
ASAC_0875	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
ASAC_0878	ENOG4105E2R	ROK family
ASAC_0885	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
ASAC_0891	ENOG4105BZA	Phosphoglycerate kinase
ASAC_0896	ENOG4105E50	uracil-dna glycosylase
ASAC_0898	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
ASAC_0901	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
ASAC_0902	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
ASAC_0904	ENOG4105CAS	nag kinase
ASAC_0906	ENOG4105CFI	type iii restriction protein res subunit
ASAC_0917	ENOG4107R56	PP-loop domain protein
ASAC_0921	ENOG4105CQR	helicase
ASAC_0924	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
ASAC_0925	ENOG4105D1H	recombination factor protein RarA
ASAC_0926	ENOG4105CEY	Amp-dependent synthetase and ligase
ASAC_0932	ENOG4105D3R	alkyl hydroperoxide reductase
ASAC_0933	ENOG4105D1F	ATP-binding protein
ASAC_0934	ENOG41082UH	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
ASAC_0936	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
ASAC_0937	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
ASAC_0939	ENOG4108UVJ	appr-1-p processing domain protein
ASAC_0942	ENOG4105EE1	crotonyl-CoA reductase
ASAC_0944	ENOG4105KME	endoribonuclease L-psp
ASAC_0945	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
ASAC_0948	ENOG4105NBF	ammecr1 domain protein
ASAC_0953	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ASAC_0954	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
ASAC_0957	ENOG4107WZZ	SMC domain protein
ASAC_0957	ENOG4107WZZ	SMC domain protein
ASAC_0964	ENOG4105C2X	Arabinose 5-phosphate isomerase
ASAC_0967	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
ASAC_0968	ENOG4105CD3	dihydroorotase
ASAC_0969	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
ASAC_0970	ENOG4105CXT	aspartate transcarbamylase
ASAC_0971	ENOG4107YIW	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
ASAC_0972	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
ASAC_0974	ENOG4105DTQ	mandelate racemase muconate lactonizing
ASAC_0977	ENOG4107SJ9	decarboxylase
ASAC_0982	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
ASAC_0983	ENOG4105I1K	ABC transporter
ASAC_0984	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
ASAC_0985	ENOG4105EHU	Circadian clock protein KaiC
ASAC_0989	ENOG4105K63	Thioredoxin
ASAC_0990	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
ASAC_0994	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
ASAC_0995	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
ASAC_0997	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
ASAC_1001	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
ASAC_1003	ENOG4105CE9	30S ribosomal protein S2
ASAC_1005	ENOG4108UJD	30S ribosomal protein S9
ASAC_1006	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
ASAC_1007	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
ASAC_1009	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
ASAC_1010	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
ASAC_1011	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ASAC_1013	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ASAC_1015	ENOG4105CPC	Aldo Keto reductase
ASAC_1019	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
ASAC_1021	ENOG4105D1Z	hydroxypyruvate reductase
ASAC_1022	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
ASAC_1028	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
ASAC_1031	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
ASAC_1035	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
ASAC_1042	ENOG4105C1G	acyl-Coa dehydrogenase
ASAC_1045	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
ASAC_1049	ENOG4105E66	phosphoriboisomerase A
ASAC_1052	ENOG4107R4Q	Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity)
ASAC_1053	ENOG4105DDK	oxidoreductase, beta subunit
ASAC_1054	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
ASAC_1055	ENOG4105WGB	oxidoreductase, delta subunit
ASAC_1060	ENOG4107QRT	dEAD DEAH box helicase
ASAC_1061	ENOG4107QNK	)-transporter
ASAC_1062	ENOG4105KG3	cytidine deaminase
ASAC_1063	ENOG4107QN2	dihydrolipoyl dehydrogenase
ASAC_1066	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
ASAC_1067	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
ASAC_1069	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
ASAC_1071	ENOG4105CFI	type iii restriction protein res subunit
ASAC_1072	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
ASAC_1073	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
ASAC_1074	ENOG4108IUK	alpha amylase, catalytic
ASAC_1083	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASAC_1091	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
ASAC_1093	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
ASAC_1094	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
ASAC_1095	ENOG4108S0S	Nucleotidyl transferase
ASAC_1097	ENOG4105EM7	Selenocysteine-specific translation elongation factor
ASAC_1099	ENOG4105E3H	phosphoglycerate mutase
ASAC_1102	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
ASAC_1113	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ASAC_1114	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
ASAC_1116	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
ASAC_1131	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
ASAC_1137	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
ASAC_1138	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
ASAC_1141	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
ASAC_1148	ENOG4105C8T	Leucyl-tRNA synthetase
ASAC_1153	ENOG4105WCJ	ec 1.1.1.193
ASAC_1156	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
ASAC_1160	ENOG4105EHU	Circadian clock protein KaiC
ASAC_1161	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
ASAC_1169	ENOG4105CEP	NADH dehydrogenase
ASAC_1175	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ASAC_1177	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ASAC_1182	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
ASAC_1183	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
ASAC_1184	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
ASAC_1185	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
ASAC_1187	ENOG4105CHR	reductase
ASAC_1190	ENOG4105CR4	methylisocitrate lyase
ASAC_1202	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
ASAC_1203	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
ASAC_1204	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
ASAC_1206	ENOG4105DCI	Phosphohydrolase
ASAC_1207	ENOG41086CI	Bifunctional phosphoglucose phosphomannose isomerase
ASAC_1210	ENOG4105CD5	CoA-binding domain protein
ASAC_1211	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ASAC_1220	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
ASAC_1224	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
ASAC_1229	ENOG4107NFR	Fructose-1,6-bisphosphatase
ASAC_1230	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
ASAC_1232	ENOG4105C1G	acyl-Coa dehydrogenase
ASAC_1233	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
ASAC_1235	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
ASAC_1236	ENOG4105C3U	ABC transporter
ASAC_1237	ENOG4108JQ7	(ABC) transporter
ASAC_1242	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
ASAC_1243	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
ASAC_1244	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
ASAC_1248	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
ASAC_1253	ENOG4107VFR	oxidoreductase
ASAC_1255	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
ASAC_1260	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
ASAC_1265	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
ASAC_1266	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
ASAC_1269	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
ASAC_1273	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ASAC_1274	ENOG4105DWF	phosphomethylpyrimidine kinase
ASAC_1275	ENOG4105C45	hydrogenase expression formation protein (HypE)
ASAC_1278	ENOG4107GFK	fumarate
ASAC_1279	ENOG4105JRK	feS assembly protein SufD
ASAC_1280	ENOG4105DIW	FeS assembly protein SUFB
ASAC_1281	ENOG4105C3K	feS assembly ATPase SufC
ASAC_1283	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
ASAC_1284	ENOG4105C85	amino acid
ASAC_1285	ENOG4107R0P	L-ribulose-5-phosphate 4-epimerase
ASAC_1289	ENOG4105BZJ	Electron transfer flavoprotein
ASAC_1290	ENOG4105C10	Electron transfer flavoprotein
ASAC_1291	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
ASAC_1292	ENOG4105DQU	oxidoreductase, subunit beta
ASAC_1295	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
ASAC_1296	ENOG4108R8B	oxidoreductase Fe-S subunit
ASAC_1298	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
ASAC_1300	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
ASAC_1303	ENOG41066VF	YeeE YedE family protein
ASAC_1304	ENOG4105D82	Glutamate dehydrogenase
ASAC_1305	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASAC_1307	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
ASAC_1310	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
ASAC_1311	ENOG4105HDK	L-asparaginase
ASAC_1316	ENOG4105C7B	Threonine dehydratase
ASAC_1330	ENOG4107QM5	aconitate hydratase
ASAC_1332	ENOG4106HB6	Alpha beta hydrolase
ASAC_1337	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
ASAC_1338	ENOG4105CQB	FAD linked oxidase domain protein
ASAC_1340	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
ASAC_1341	ENOG4105CE4	GlcNAc 6-P deacetylase
ASAC_1354	ENOG4105CQ2	DNA polymerase
ASAC_1356	ENOG410805Y	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
ASAC_1360	ENOG4106KE4	Dehydrogenase
ASAC_1365	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
ASAC_1369	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
ASAC_1370	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
ASAC_1371	ENOG4107QN2	dihydrolipoyl dehydrogenase
ASAC_1372	ENOG41082UM	UPF0102 protein
ASAC_1373	ENOG4108IUW	ABC transporter
ASAC_1378	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
ASAC_1381	ENOG4108JQ7	(ABC) transporter
ASAC_1382	ENOG4108JQ7	(ABC) transporter
ASAC_1384	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
ASAC_1387	ENOG4105BZA	Phosphoglycerate kinase
ASAC_1388	ENOG4107YZX	Universal stress protein
ASAC_1389	ENOG4107RGD	Major Facilitator superfamily
ASAC_1391	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
ASAC_1392	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
ASAC_1396	ENOG4107QIZ	NADH dehydrogenase
ASAC_1397	ENOG4108IEG	Formate dehydrogenase Alpha subunit
ASAC_1398	ENOG41080QG	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
ASAC_1401	ENOG4108DNI	pyridine nucleotide-disulfide oxidoreductase
ASAC_1402	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
ASAC_1403	ENOG4105DC7	peptidase M24
ASAC_1412	ENOG4105CJ1	ABC, transporter
ASAC_1426	ENOG4105BZ8	glutamate synthase
ASAC_1429	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
ASAC_1433	ENOG4106YT9	Enoyl-CoA hydratase
ASAC_1435	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
ASAC_1437	ENOG4105CSH	Transporter
ASAC_1438	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
ASAC_1445	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
ASAC_1451	ENOG4105C5R	Aminotransferase
ASAC_1452	ENOG4105IIU	Aminopeptidase
ASAC_1457	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
ASAC_1458	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
ASAC_1468	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
ASAC_1473	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ASAC_1477	ENOG4105CJ1	ABC, transporter
ASAC_1478	ENOG4105CHR	reductase
ASAC_1484	ENOG4105CUT	histidyl-tRNA synthetase
ASAC_1490	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
ASAC_1494	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
ASAC_1497	ENOG4107QTZ	amino acid