locus-tag	class	description
ASAC_0006	COG1518	maintenance of DNA repeat elements
ASAC_0006	COG1468	defense response to virus
ASAC_0020	COG1131	(ABC) transporter
ASAC_0022	COG1201	RNA secondary structure unwinding
ASAC_0026	COG0183	Belongs to the thiolase family
ASAC_0028	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ASAC_0029	COG1830	Aldolase
ASAC_0030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASAC_0031	COG0163	prenyltransferase activity
ASAC_0037	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ASAC_0041	COG0667	Aldo Keto reductase
ASAC_0044	COG1139	Iron-sulfur cluster binding protein
ASAC_0048	COG0494	nUDIX hydrolase
ASAC_0049	COG1506	peptidase
ASAC_0049	COG0823	Involved in the tonB-independent uptake of proteins
ASAC_0049	COG4946	Tricorn protease homolog
ASAC_0053	COG2046	Belongs to the sulfate adenylyltransferase family
ASAC_0055	COG0529	Catalyzes the synthesis of activated sulfate
ASAC_0059	COG0673	inositol 2-dehydrogenase activity
ASAC_0061	COG0601	transmembrane transport
ASAC_0064	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASAC_0068	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ASAC_0072	COG1489	DNA binding
ASAC_0077	COG0585	pseudouridine synthase activity
ASAC_0078	COG1216	Glycosyl transferase, family 2
ASAC_0080	COG0463	Glycosyl transferase, family 2
ASAC_0082	COG0714	Associated with various cellular activities
ASAC_0085	COG3842	ATPase activity
ASAC_0086	COG3833	ABC-type maltose transport systems, permease component
ASAC_0087	COG1175	transmembrane transport
ASAC_0092	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ASAC_0094	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASAC_0096	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASAC_0097	COG1144	Oxidoreductase
ASAC_0098	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASAC_0099	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASAC_0100	COG0531	amino acid
ASAC_0101	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ASAC_0104	COG0113	porphobilinogen synthase activity
ASAC_0106	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ASAC_0107	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASAC_0108	COG1881	PFAM PEBP family protein
ASAC_0111	COG0535	radical SAM domain protein
ASAC_0116	COG2235	arginine
ASAC_0117	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
ASAC_0119	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ASAC_0120	COG0247	lactate metabolic process
ASAC_0120	COG2181	nitrate reductase activity
ASAC_0130	COG0417	DNA replication proofreading
ASAC_0137	COG0423	glycine-tRNA ligase activity
ASAC_0140	COG0023	Translation Initiation Factor
ASAC_0144	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASAC_0146	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ASAC_0155	COG1960	acyl-CoA dehydrogenase activity
ASAC_0159	COG2095	MarC family integral membrane protein
ASAC_0162	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ASAC_0175	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ASAC_0176	COG1024	Enoyl-CoA hydratase
ASAC_0179	COG0314	molybdopterin synthase activity
ASAC_0181	COG1201	RNA secondary structure unwinding
ASAC_0185	COG1047	Peptidyl-prolyl cis-trans
ASAC_0187	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ASAC_0187	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ASAC_0188	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ASAC_0192	COG1234	tRNA 3'-trailer cleavage
ASAC_0195	COG0463	Glycosyl transferase, family 2
ASAC_0203	COG1185	polyribonucleotide nucleotidyltransferase activity
ASAC_0213	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
ASAC_0217	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ASAC_0219	COG1899	peptidyl-lysine modification to peptidyl-hypusine
ASAC_0223	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ASAC_0225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ASAC_0228	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ASAC_0232	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ASAC_0233	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ASAC_0234	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ASAC_0236	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASAC_0241	COG0215	cysteine-tRNA ligase activity
ASAC_0244	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ASAC_0258	COG0492	ferredoxin-NADP+ reductase activity
ASAC_0259	COG1802	Transcriptional regulator
ASAC_0264	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ASAC_0265	COG2086	electron transfer activity
ASAC_0267	COG0644	oxidoreductase
ASAC_0269	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ASAC_0270	COG1668	transmembrane transport
ASAC_0271	COG1131	(ABC) transporter
ASAC_0274	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ASAC_0275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ASAC_0281	COG1994	Peptidase M50
ASAC_0285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ASAC_0288	COG0039	L-malate dehydrogenase activity
ASAC_0291	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ASAC_0295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASAC_0305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ASAC_0308	COG0343	queuine tRNA-ribosyltransferase activity
ASAC_0312	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ASAC_0315	COG0371	Dehydrogenase
ASAC_0316	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASAC_0317	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ASAC_0321	COG0183	Belongs to the thiolase family
ASAC_0322	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ASAC_0323	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ASAC_0327	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASAC_0331	COG1304	FMN binding
ASAC_0334	COG3281	Trehalose synthase
ASAC_0337	COG0072	phenylalanine-tRNA ligase activity
ASAC_0338	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ASAC_0340	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
ASAC_0345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ASAC_0347	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASAC_0348	COG0037	tRNA processing
ASAC_0352	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASAC_0353	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASAC_0363	COG0297	glycogen (starch) synthase activity
ASAC_0365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ASAC_0366	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASAC_0367	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ASAC_0369	COG3842	ATPase activity
ASAC_0374	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ASAC_0375	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASAC_0379	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ASAC_0380	COG0649	NAD binding
ASAC_0381	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASAC_0382	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASAC_0386	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ASAC_0389	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASAC_0391	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ASAC_0392	COG0442	prolyl-tRNA aminoacylation
ASAC_0394	COG0717	Belongs to the dCTP deaminase family
ASAC_0396	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASAC_0398	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ASAC_0400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASAC_0402	COG0504	CTP synthase activity
ASAC_0406	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASAC_0410	COG0017	Asparaginyl-tRNA synthetase
ASAC_0416	COG1269	ATP hydrolysis coupled proton transport
ASAC_0417	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
ASAC_0419	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
ASAC_0420	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
ASAC_0428	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASAC_0428	COG0551	DNA topoisomerase type I activity
ASAC_0430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASAC_0434	COG0247	lactate metabolic process
ASAC_0437	COG1201	RNA secondary structure unwinding
ASAC_0438	COG0459	protein refolding
ASAC_0443	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ASAC_0444	COG1129	ABC transporter
ASAC_0445	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ASAC_0446	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ASAC_0450	COG2890	protein-(glutamine-N5) methyltransferase activity
ASAC_0451	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ASAC_0458	COG0017	Asparaginyl-tRNA synthetase
ASAC_0461	COG2017	converts alpha-aldose to the beta-anomer
ASAC_0463	COG2860	membrane
ASAC_0466	COG0154	amidase activity
ASAC_0467	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASAC_0476	COG3842	ATPase activity
ASAC_0478	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ASAC_0479	COG2151	metal-sulfur cluster biosynthetic enzyme
ASAC_0481	COG1546	Belongs to the CinA family
ASAC_0481	COG1058	Belongs to the CinA family
ASAC_0485	COG0483	inositol monophosphate 1-phosphatase activity
ASAC_0488	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ASAC_0493	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ASAC_0499	COG1120	ATPase activity
ASAC_0500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASAC_0501	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ASAC_0502	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ASAC_0511	COG0318	PFAM AMP-dependent synthetase and ligase
ASAC_0515	COG1321	iron dependent repressor
ASAC_0516	COG0864	Transcriptional regulator
ASAC_0521	COG0537	adenosine 5'-monophosphoramidase activity
ASAC_0522	COG0587	DNA-directed DNA polymerase activity
ASAC_0524	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ASAC_0530	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ASAC_0531	COG0426	domain, Protein
ASAC_0533	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ASAC_0537	COG0114	fumarate hydratase activity
ASAC_0539	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASAC_0541	COG0730	response to heat
ASAC_0544	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ASAC_0546	COG4670	ketone body catabolic process
ASAC_0548	COG0095	Lipoate-protein ligase
ASAC_0549	COG0517	IMP dehydrogenase activity
ASAC_0549	COG0516	GMP reductase activity
ASAC_0551	COG0514	ATP-dependent DNA helicase (RecQ)
ASAC_0554	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASAC_0557	COG2814	Major facilitator Superfamily
ASAC_0560	COG0726	polysaccharide deacetylase
ASAC_0563	COG1028	Short-chain dehydrogenase reductase Sdr
ASAC_0567	COG0179	Fumarylacetoacetate (FAA) hydrolase
ASAC_0568	COG0667	Aldo Keto reductase
ASAC_0569	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ASAC_0572	COG2986	histidine ammonia-lyase
ASAC_0573	COG0010	Belongs to the arginase family
ASAC_0576	COG2409	Drug exporters of the RND superfamily
ASAC_0579	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASAC_0581	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ASAC_0582	COG1960	acyl-CoA dehydrogenase activity
ASAC_0584	COG0450	alkyl hydroperoxide reductase
ASAC_0588	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ASAC_0590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASAC_0597	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASAC_0598	COG1584	GPR1 FUN34 yaaH family protein
ASAC_0602	COG0477	Major facilitator Superfamily
ASAC_0618	COG0301	tRNA thio-modification
ASAC_0623	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASAC_0630	COG0604	alcohol dehydrogenase
ASAC_0632	COG1575	Belongs to the MenA family. Type 1 subfamily
ASAC_0634	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
ASAC_0637	COG1215	transferase activity, transferring glycosyl groups
ASAC_0655	COG2264	protein methyltransferase activity
ASAC_0662	COG1215	transferase activity, transferring glycosyl groups
ASAC_0667	COG1215	transferase activity, transferring glycosyl groups
ASAC_0678	COG0438	transferase activity, transferring glycosyl groups
ASAC_0680	COG1215	transferase activity, transferring glycosyl groups
ASAC_0681	COG0297	glycogen (starch) synthase activity
ASAC_0684	COG1215	transferase activity, transferring glycosyl groups
ASAC_0698	COG2414	aldehyde ferredoxin oxidoreductase
ASAC_0700	COG1454	alcohol dehydrogenase
ASAC_0701	COG0393	Putative heavy-metal-binding
ASAC_0704	COG1228	amidohydrolase
ASAC_0705	COG1132	(ABC) transporter
ASAC_0708	COG2210	Belongs to the sulfur carrier protein TusA family
ASAC_0713	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASAC_0728	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ASAC_0739	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASAC_0739	COG0574	Belongs to the PEP-utilizing enzyme family
ASAC_0742	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ASAC_0743	COG1012	belongs to the aldehyde dehydrogenase family
ASAC_0747	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASAC_0752	COG0009	L-threonylcarbamoyladenylate synthase
ASAC_0759	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASAC_0762	COG2414	aldehyde ferredoxin oxidoreductase
ASAC_0764	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ASAC_0765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ASAC_0772	COG1501	Belongs to the glycosyl hydrolase 31 family
ASAC_0773	COG0531	amino acid
ASAC_0774	COG1215	transferase activity, transferring glycosyl groups
ASAC_0779	COG2096	Adenosyltransferase
ASAC_0780	COG1012	belongs to the aldehyde dehydrogenase family
ASAC_0782	COG1612	heme a metabolic process
ASAC_0782	COG0109	protoheme IX farnesyltransferase activity
ASAC_0783	COG0730	response to heat
ASAC_0786	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASAC_0788	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASAC_0789	COG1085	galactose-1-phosphate uridylyltransferase
ASAC_0791	COG1254	Belongs to the acylphosphatase family
ASAC_0794	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ASAC_0795	COG0463	Glycosyl transferase, family 2
ASAC_0797	COG0154	amidase activity
ASAC_0799	COG0559	Belongs to the binding-protein-dependent transport system permease family
ASAC_0803	COG1446	asparaginase
ASAC_0805	COG0601	transmembrane transport
ASAC_0807	COG0444	Belongs to the ABC transporter superfamily
ASAC_0808	COG4608	Belongs to the ABC transporter superfamily
ASAC_0812	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ASAC_0816	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ASAC_0817	COG0538	isocitrate dehydrogenase activity
ASAC_0823	COG0430	RNA-3'-phosphate cyclase activity
ASAC_0827	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASAC_0830	COG1324	tolerance protein
ASAC_0832	COG0148	phosphopyruvate hydratase activity
ASAC_0833	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ASAC_0840	COG1028	Short-chain dehydrogenase reductase Sdr
ASAC_0843	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ASAC_0843	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ASAC_0847	COG1335	isochorismatase
ASAC_0850	COG1575	Belongs to the MenA family. Type 1 subfamily
ASAC_0858	COG0516	GMP reductase activity
ASAC_0858	COG0517	IMP dehydrogenase activity
ASAC_0859	COG0519	Catalyzes the synthesis of GMP from XMP
ASAC_0859	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASAC_0860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ASAC_0871	COG0372	Belongs to the citrate synthase family
ASAC_0874	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASAC_0875	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASAC_0875	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASAC_0878	COG1940	carbohydrate kinase activity
ASAC_0885	COG1573	uracil-dna glycosylase
ASAC_0891	COG0126	phosphoglycerate kinase activity
ASAC_0896	COG1573	uracil-dna glycosylase
ASAC_0902	COG1355	regulation of microtubule-based process
ASAC_0904	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASAC_0906	COG1061	Type III restriction enzyme res subunit
ASAC_0910	COG0330	HflC and HflK could
ASAC_0917	COG0037	tRNA processing
ASAC_0921	COG4581	dead DEAH box helicase
ASAC_0925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ASAC_0926	COG0318	PFAM AMP-dependent synthetase and ligase
ASAC_0927	COG4948	Mandelate Racemase Muconate Lactonizing
ASAC_0932	COG0450	alkyl hydroperoxide reductase
ASAC_0933	COG0489	protein tyrosine kinase activity
ASAC_0934	COG0089	rRNA binding
ASAC_0936	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ASAC_0937	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASAC_0939	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ASAC_0940	COG1116	anion transmembrane transporter activity
ASAC_0944	COG0251	oxidation-reduction process
ASAC_0945	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ASAC_0945	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ASAC_0948	COG2078	PFAM AMMECR1 domain protein
ASAC_0953	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASAC_0954	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ASAC_0957	COG0419	ATPase involved in DNA repair
ASAC_0957	COG0419	ATPase involved in DNA repair
ASAC_0959	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ASAC_0964	COG0517	IMP dehydrogenase activity
ASAC_0964	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ASAC_0967	COG0167	dihydroorotate dehydrogenase activity
ASAC_0968	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASAC_0969	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ASAC_0970	COG0540	Belongs to the ATCase OTCase family
ASAC_0971	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ASAC_0974	COG4948	Mandelate Racemase Muconate Lactonizing
ASAC_0982	COG1175	transmembrane transport
ASAC_0984	COG3842	ATPase activity
ASAC_0985	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ASAC_0989	COG3118	belongs to the thioredoxin family
ASAC_0990	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ASAC_0994	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ASAC_0995	COG0521	Mo-molybdopterin cofactor biosynthetic process
ASAC_0997	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASAC_1001	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ASAC_1003	COG0052	Belongs to the universal ribosomal protein uS2 family
ASAC_1006	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ASAC_1007	COG0200	Binds to the 23S rRNA
ASAC_1009	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ASAC_1010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ASAC_1011	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ASAC_1013	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ASAC_1015	COG0667	Aldo Keto reductase
ASAC_1019	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASAC_1021	COG2379	hydroxypyruvate reductase
ASAC_1022	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ASAC_1022	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASAC_1028	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASAC_1031	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASAC_1035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASAC_1042	COG1960	acyl-CoA dehydrogenase activity
ASAC_1045	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ASAC_1049	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ASAC_1052	COG0714	Associated with various cellular activities
ASAC_1053	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASAC_1054	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASAC_1055	COG1144	Oxidoreductase
ASAC_1060	COG1201	RNA secondary structure unwinding
ASAC_1061	COG2814	Major facilitator Superfamily
ASAC_1062	COG0295	cytidine deaminase activity
ASAC_1063	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASAC_1066	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ASAC_1067	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ASAC_1069	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASAC_1069	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASAC_1071	COG1061	Type III restriction enzyme res subunit
ASAC_1072	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ASAC_1073	COG0045	succinate-CoA ligase (ADP-forming) activity
ASAC_1074	COG0366	Alpha amylase catalytic
ASAC_1083	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASAC_1091	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASAC_1093	COG0105	UTP biosynthetic process
ASAC_1094	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASAC_1099	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
ASAC_1102	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ASAC_1113	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ASAC_1114	COG0516	GMP reductase activity
ASAC_1114	COG0517	IMP dehydrogenase activity
ASAC_1116	COG0517	IMP dehydrogenase activity
ASAC_1116	COG0516	GMP reductase activity
ASAC_1137	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ASAC_1138	COG1185	polyribonucleotide nucleotidyltransferase activity
ASAC_1141	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASAC_1148	COG0495	leucyl-tRNA aminoacylation
ASAC_1153	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASAC_1156	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASAC_1160	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ASAC_1161	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
ASAC_1166	COG2814	Major facilitator Superfamily
ASAC_1169	COG1252	NADH dehydrogenase
ASAC_1175	COG0085	RNA polymerase activity
ASAC_1177	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASAC_1182	COG0049	tRNA binding
ASAC_1183	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASAC_1184	COG0051	transcription antitermination factor activity, RNA binding
ASAC_1185	COG1793	dna ligase
ASAC_1187	COG1028	Short-chain dehydrogenase reductase Sdr
ASAC_1190	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ASAC_1202	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASAC_1203	COG0181	hydroxymethylbilane synthase activity
ASAC_1204	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ASAC_1206	COG1078	dGTPase activity
ASAC_1207	COG2222	sugar isomerase
ASAC_1211	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASAC_1229	COG1980	fructose-bisphosphate aldolase activity
ASAC_1230	COG2022	thiamine diphosphate biosynthetic process
ASAC_1232	COG1960	acyl-CoA dehydrogenase activity
ASAC_1233	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ASAC_1235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASAC_1236	COG0444	Belongs to the ABC transporter superfamily
ASAC_1237	COG4608	Belongs to the ABC transporter superfamily
ASAC_1242	COG1110	DNA topoisomerase II activity
ASAC_1243	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ASAC_1244	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ASAC_1248	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ASAC_1253	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASAC_1255	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ASAC_1260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASAC_1265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASAC_1266	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ASAC_1269	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ASAC_1273	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ASAC_1274	COG0351	phosphomethylpyrimidine kinase
ASAC_1275	COG0309	Hydrogenase expression formation protein (HypE)
ASAC_1279	COG0719	Fe-S assembly protein
ASAC_1280	COG0719	Fe-S assembly protein
ASAC_1281	COG0396	ATPase activity
ASAC_1283	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASAC_1289	COG2086	electron transfer activity
ASAC_1290	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ASAC_1291	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASAC_1291	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASAC_1292	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASAC_1295	COG2414	aldehyde ferredoxin oxidoreductase
ASAC_1296	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ASAC_1298	COG0535	radical SAM domain protein
ASAC_1300	COG1051	belongs to the nudix hydrolase family
ASAC_1303	COG2391	methyltransferase activity
ASAC_1304	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ASAC_1305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASAC_1307	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ASAC_1310	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASAC_1311	COG0252	asparaginase activity
ASAC_1316	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ASAC_1318	COG1522	sequence-specific DNA binding
ASAC_1330	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ASAC_1337	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ASAC_1338	COG0277	FAD linked oxidase domain protein
ASAC_1340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASAC_1341	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ASAC_1354	COG0417	DNA replication proofreading
ASAC_1356	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ASAC_1360	COG2084	Dehydrogenase
ASAC_1365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASAC_1370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASAC_1371	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASAC_1372	COG0792	nuclease activity
ASAC_1373	COG4555	ABC transporter
ASAC_1378	COG1472	Belongs to the glycosyl hydrolase 3 family
ASAC_1381	COG4608	Belongs to the ABC transporter superfamily
ASAC_1382	COG4608	Belongs to the ABC transporter superfamily
ASAC_1384	COG0601	transmembrane transport
ASAC_1387	COG0126	phosphoglycerate kinase activity
ASAC_1388	COG0589	response to stress
ASAC_1389	COG2814	Major facilitator Superfamily
ASAC_1390	COG2723	6-phospho-beta-galactosidase activity
ASAC_1391	COG1575	Belongs to the MenA family. Type 1 subfamily
ASAC_1392	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ASAC_1397	COG3383	formate dehydrogenase (NAD+) activity
ASAC_1398	COG0746	molybdenum cofactor guanylyltransferase activity
ASAC_1403	COG0006	proline dipeptidase activity
ASAC_1412	COG1131	(ABC) transporter
ASAC_1426	COG0493	'glutamate synthase
ASAC_1429	COG2226	methyltransferase
ASAC_1432	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ASAC_1433	COG1024	Enoyl-CoA hydratase
ASAC_1435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASAC_1437	COG0477	Major facilitator Superfamily
ASAC_1438	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASAC_1440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ASAC_1442	COG2009	succinate dehydrogenase
ASAC_1445	COG0509	glycine decarboxylation via glycine cleavage system
ASAC_1446	COG0312	modulator of DNA gyrase
ASAC_1449	COG0471	metal ion transport
ASAC_1449	COG3273	potassium ion transport
ASAC_1451	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ASAC_1452	COG2234	aminopeptidase activity
ASAC_1452	COG4935	Belongs to the peptidase S8 family
ASAC_1458	COG1444	tRNA N-acetyltransferase activity
ASAC_1468	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ASAC_1477	COG1131	(ABC) transporter
ASAC_1478	COG1028	Short-chain dehydrogenase reductase Sdr
ASAC_1484	COG0124	histidyl-tRNA synthetase
ASAC_1490	COG0442	prolyl-tRNA aminoacylation
ASAC_1494	COG0588	phosphoglycerate mutase activity
ASAC_1497	COG0531	amino acid