locus-tag	class	description
Afer_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Afer_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Afer_0003	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
Afer_0006	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Afer_0008	ENOG4108EHY	type IV secretion system
Afer_0020	ENOG4106UDK	Cellulose-binding, family II
Afer_0028	ENOG4105EPR	degv family
Afer_0030	ENOG4105C3M	thioredoxin reductase
Afer_0032	ENOG4108E1C	hydrolase
Afer_0035	ENOG4107T66	Releases the N-terminal proline from various substrates (By similarity)
Afer_0037	ENOG4105CZA	synthase
Afer_0040	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Afer_0042	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Afer_0043	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Afer_0045	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
Afer_0051	ENOG4105DF6	Fe-S oxidoreductase
Afer_0052	ENOG4105DHP	deoxycytidine triphosphate deaminase
Afer_0065	ENOG4107QWR	cellulase (EC 3.2.1.4)
Afer_0076	ENOG4105DY8	decarboxylase
Afer_0077	ENOG4107Z60	histidine triad (HIT) protein
Afer_0078	ENOG4108DNI	pyridine nucleotide-disulfide oxidoreductase
Afer_0079	ENOG4105K4P	CoA-binding domain protein
Afer_0080	ENOG4105F9U	Dehydrogenase
Afer_0082	ENOG4105CUT	histidyl-tRNA synthetase
Afer_0084	ENOG4105CPN	adenine deaminase
Afer_0085	ENOG4105CHU	acetyl-coa acetyltransferase
Afer_0086	ENOG4105DDQ	anthranilate synthase
Afer_0088	ENOG4105D9P	serine threonine protein kinase
Afer_0094	ENOG4105DXM	phenylacetic acid degradation protein
Afer_0097	ENOG4105CQC	Prephenate dehydratase
Afer_0098	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
Afer_0099	ENOG4105C8M	UPF0272 protein
Afer_0101	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
Afer_0102	ENOG4105C6E	dna polymerase iii
Afer_0103	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Afer_0106	ENOG4105CHU	acetyl-coa acetyltransferase
Afer_0107	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
Afer_0111	ENOG4105CFH	Aspartokinase
Afer_0113	ENOG4105I03	Flagellin
Afer_0114	ENOG4107TPX	flagellar hook-associated
Afer_0119	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
Afer_0120	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
Afer_0124	ENOG4105KNY	Microcompartments protein
Afer_0125	ENOG4105KNY	Microcompartments protein
Afer_0126	ENOG4105KNY	Microcompartments protein
Afer_0132	ENOG4105FAE	von Willebrand factor, type A
Afer_0133	ENOG4105EVH	UPF0753 protein
Afer_0134	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
Afer_0137	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
Afer_0138	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Afer_0140	ENOG4108JIR	Flagellum-specific ATP synthase
Afer_0142	ENOG4105E4C	Lytic transglycosylase catalytic
Afer_0144	ENOG410822I	Flagellar hook capping protein
Afer_0145	ENOG4105BZE	flagellar hook protein, FlgE
Afer_0147	ENOG4105E14	MotA TolQ exbB proton channel
Afer_0148	ENOG4105ER2	Ompa motb domain protein
Afer_0151	ENOG4105DD5	Flagellar motor switch protein
Afer_0154	ENOG4105DQ6	Transposase
Afer_0155	ENOG4105CN7	Flagellar biosynthetic protein FliP
Afer_0158	ENOG4105D00	flagellar biosynthetic protein flhB
Afer_0159	ENOG4105D7B	Flagellar biosynthesis protein flha
Afer_0162	ENOG4105WZW	rhodanese family
Afer_0163	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
Afer_0164	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Afer_0165	ENOG4105DJV	ribulose-phosphate 3-epimerase
Afer_0167	ENOG4105DBI	uridine monophosphokinase
Afer_0169	ENOG4105ETE	Transcriptional regulator (LacI family
Afer_0170	ENOG4105F2F	Xylan 1,4-beta-xylosidase (EC 3.2.1.37)
Afer_0173	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Afer_0176	ENOG4105DDW	LysR family Transcriptional regulator
Afer_0177	ENOG4107R1Y	fructose-bisphosphate aldolase
Afer_0180	ENOG4105WH1	Two component transcriptional regulator luxr family
Afer_0183	ENOG4105MS9	Resuscitation-promoting factor
Afer_0185	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
Afer_0190	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Afer_0194	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
Afer_0197	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
Afer_0198	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
Afer_0200	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Afer_0201	ENOG4105BZU	Histidine kinase
Afer_0208	ENOG4105CGA	flagellar basal-body rod protein FlgG
Afer_0210	ENOG4105W5T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
Afer_0211	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
Afer_0212	ENOG4105CBS	Chea signal transduction histidine kinase
Afer_0213	ENOG4105YFD	chemotaxis, protein
Afer_0214	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
Afer_0215	ENOG4105BZU	Histidine kinase
Afer_0220	ENOG4106WTF	Glycosyl transferase, family 2
Afer_0222	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Afer_0223	ENOG4105RFZ	Methylmalonyl-coA mutase
Afer_0225	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
Afer_0231	ENOG4105D8K	carboxyl transferase
Afer_0240	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
Afer_0241	ENOG4107NHD	transcriptional regulator
Afer_0242	ENOG4105C5F	glutamine synthetase
Afer_0243	ENOG4105C5F	glutamine synthetase
Afer_0246	ENOG4105C4K	Nad synthetase
Afer_0249	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Afer_0250	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
Afer_0253	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Afer_0257	ENOG4105CHR	reductase
Afer_0261	ENOG4105CHU	acetyl-coa acetyltransferase
Afer_0264	ENOG4105FJR	Lmbe family
Afer_0266	ENOG4105CPC	Aldo Keto reductase
Afer_0269	ENOG4105C6T	cysteine synthase
Afer_0270	ENOG4105BZ1	(ABC) transporter
Afer_0271	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
Afer_0272	ENOG4105C7I	Dehydrogenase
Afer_0285	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Afer_0286	ENOG4105C1J	atp-dependent rna helicase
Afer_0291	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
Afer_0295	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
Afer_0296	ENOG4105K8R	UPF0145 protein
Afer_0297	ENOG4107SFI	Major Facilitator superfamily
Afer_0301	ENOG4105DQ6	Transposase
Afer_0305	ENOG4105C1G	acyl-Coa dehydrogenase
Afer_0306	ENOG4105C8N	cysteinyl-tRNA synthetase
Afer_0307	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Afer_0308	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
Afer_0309	ENOG41080HT	Transcriptional regulator, arsr family
Afer_0311	ENOG4105EET	magnesium chelatase
Afer_0312	ENOG4108J01	L-aspartate oxidase
Afer_0313	ENOG4105E33	succinate dehydrogenase
Afer_0317	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
Afer_0319	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Afer_0320	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Afer_0322	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Afer_0323	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Afer_0324	ENOG4105SYT	Methylenetetrahydrofolate reductase
Afer_0325	ENOG4105C54	Major Facilitator superfamily
Afer_0328	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
Afer_0329	ENOG4105CCS	Glutamate formiminotransferase
Afer_0330	ENOG4105XEA	Tetr family transcriptional regulator
Afer_0331	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
Afer_0332	ENOG4105CIG	ABC transporter
Afer_0334	ENOG41060IM	Heme exporter protein
Afer_0337	ENOG4105DA4	cytochrome c-type biogenesis protein
Afer_0338	ENOG4107QX9	Thiol disulfide interChange protein
Afer_0339	ENOG4105KWW	Biogenesis protein
Afer_0341	ENOG4105C54	Major Facilitator superfamily
Afer_0345	ENOG4108M15	ABC transporter
Afer_0347	ENOG4105D1F	ATP-binding protein
Afer_0353	ENOG4105BZJ	Electron transfer flavoprotein
Afer_0354	ENOG4105C10	Electron transfer flavoprotein
Afer_0355	ENOG4108VEQ	Superoxide dismutase
Afer_0358	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Afer_0361	ENOG4105E2K	Glycosyl transferase (Group 1
Afer_0362	ENOG4105P52	geranylgeranyl reductase
Afer_0363	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Afer_0364	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Afer_0365	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Afer_0366	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Afer_0369	ENOG4108IEH	NADH dehydrogenase subunit g
Afer_0370	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Afer_0371	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Afer_0373	ENOG41080FQ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Afer_0374	ENOG4105D65	subunit l
Afer_0376	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Afer_0378	ENOG4105CRK	lysyL-tRNA synthetase
Afer_0379	ENOG4108VPT	UPF0234 protein
Afer_0380	ENOG4107JC6	Membrane
Afer_0382	ENOG4108Z7F	N-acetyltransferase
Afer_0383	ENOG4105WDJ	50S ribosomal protein L33
Afer_0385	ENOG410683Z	Preprotein translocase SecE subunit
Afer_0386	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
Afer_0387	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Afer_0388	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Afer_0389	ENOG4108VZM	50s ribosomal protein L10
Afer_0390	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Afer_0391	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Afer_0392	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Afer_0393	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Afer_0394	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Afer_0395	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Afer_0396	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Afer_0397	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Afer_0398	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Afer_0400	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Afer_0401	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Afer_0402	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Afer_0403	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Afer_0405	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Afer_0406	ENOG41082SA	50s ribosomal protein l29
Afer_0407	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Afer_0408	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Afer_0409	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Afer_0410	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Afer_0411	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Afer_0412	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Afer_0413	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Afer_0414	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Afer_0415	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Afer_0416	ENOG410849U	50S ribosomal protein L30
Afer_0419	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Afer_0421	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Afer_0422	ENOG41067V7	50S ribosomal protein L36
Afer_0423	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Afer_0424	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Afer_0425	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Afer_0426	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Afer_0427	ENOG4108ZT0	50S ribosomal protein l17
Afer_0428	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Afer_0429	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Afer_0430	ENOG4108UJD	30S ribosomal protein S9
Afer_0431	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Afer_0432	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Afer_0434	ENOG4105DUM	transcriptional regulator, lysR family
Afer_0435	ENOG41082KK	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
Afer_0436	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Afer_0437	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Afer_0438	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Afer_0441	ENOG410801F	ribosomal-protein-alanine acetyltransferase
Afer_0442	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Afer_0443	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Afer_0444	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Afer_0453	ENOG4105P8F	nudix hydrolase
Afer_0455	ENOG41083TI	Protein CrcB homolog
Afer_0459	ENOG4107QVP	Dehydrogenase
Afer_0460	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Afer_0471	ENOG4105EAH	synthase
Afer_0472	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
Afer_0475	ENOG4105CJW	magnesium transporter
Afer_0476	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
Afer_0477	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Afer_0478	ENOG4108RAV	Conserved protein
Afer_0479	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Afer_0486	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Afer_0487	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
Afer_0489	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Afer_0490	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
Afer_0495	ENOG4105BZP	glycoside hydrolase 15-related
Afer_0498	ENOG4108SC4	)-transporter
Afer_0504	ENOG4108IV0	ABC, transporter
Afer_0505	ENOG4105C0Z	ABC transporter
Afer_0507	ENOG4105C32	Amino acid ABC transporter (Permease)
Afer_0508	ENOG4108V9W	transcriptional regulatory protein
Afer_0511	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
Afer_0519	ENOG4105DQ6	Transposase
Afer_0522	ENOG4105BZ1	(ABC) transporter
Afer_0523	ENOG4108JJ9	ABC, transporter
Afer_0524	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
Afer_0525	ENOG4105C4M	(Ubiquinol oxidase) subunit I
Afer_0526	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
Afer_0527	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Afer_0528	ENOG4105F8V	Hydrolase, tatD family
Afer_0529	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Afer_0530	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
Afer_0532	ENOG4105C3G	gtp-binding protein
Afer_0534	ENOG4105C9M	aspartyl-trna synthetase
Afer_0537	ENOG41080Z7	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
Afer_0540	ENOG4107ZIM	Dtdp-4-dehydrorhamnose 3,5-epimerase
Afer_0543	ENOG4105DIW	FeS assembly protein SUFB
Afer_0557	ENOG4105BZU	Histidine kinase
Afer_0558	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Afer_0560	ENOG41060WC	Enoyl-CoA hydratase
Afer_0561	ENOG4105JRK	feS assembly protein SufD
Afer_0563	ENOG4105C3K	feS assembly ATPase SufC
Afer_0566	ENOG4105C3K	feS assembly ATPase SufC
Afer_0567	ENOG4105C9B	Cysteine desulfurase
Afer_0568	ENOG4108UNV	SUF system FeS assembly protein, NifU family
Afer_0572	ENOG4105BZW	Glycerate kinase
Afer_0573	ENOG4105C26	Dehydrogenase
Afer_0575	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
Afer_0582	ENOG4105D8K	carboxyl transferase
Afer_0586	ENOG4105EYF	MMPL domain protein
Afer_0587	ENOG41060WC	Enoyl-CoA hydratase
Afer_0588	ENOG4105CEY	Amp-dependent synthetase and ligase
Afer_0589	ENOG4107W19	lmbE family
Afer_0591	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Afer_0597	ENOG4108EMS	branched-chain alpha-keto acid dehydrogenase subunit E2
Afer_0598	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
Afer_0599	ENOG4105CPF	Cell wall formation (By similarity)
Afer_0602	ENOG4105DWV	Homoserine O-trans-acetylase
Afer_0603	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
Afer_0605	ENOG4107PBV	potassium channel
Afer_0609	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
Afer_0617	ENOG4105ECY	inositol monophosphatase
Afer_0621	ENOG4108UZ3	Transporter
Afer_0624	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Afer_0625	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Afer_0626	ENOG4105CE9	30S ribosomal protein S2
Afer_0627	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Afer_0628	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Afer_0629	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Afer_0630	ENOG4108HPI	phosphatidate Cytidylyltransferase
Afer_0631	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
Afer_0632	ENOG4105DZP	Membrane-associated zinc metalloprotease
Afer_0633	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
Afer_0634	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Afer_0635	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
Afer_0636	ENOG4105CHV	Transcription elongation factor NusA
Afer_0638	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Afer_0639	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
Afer_0640	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Afer_0642	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Afer_0643	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Afer_0646	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Afer_0647	ENOG4105CN5	Metallo-Beta-Lactamase
Afer_0649	ENOG41061WM	D-Alanyl-D-Alanine
Afer_0650	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
Afer_0651	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Afer_0652	ENOG4105CEV	competence damage-inducible protein
Afer_0653	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Afer_0655	ENOG4107STG	mandelate racemase muconate lactonizing
Afer_0657	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
Afer_0658	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Afer_0659	ENOG4105CHM	Aminotransferase
Afer_0660	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
Afer_0666	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
Afer_0668	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Afer_0669	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Afer_0680	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
Afer_0692	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
Afer_0693	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
Afer_0698	ENOG4105DCF	alanine dehydrogenase
Afer_0699	ENOG4105CJP	fad dependent oxidoreductase
Afer_0700	ENOG4108JPW	Aminotransferase
Afer_0703	ENOG4105ETX	regulatoR
Afer_0705	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Afer_0709	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Afer_0711	ENOG4107Y5I	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Afer_0713	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
Afer_0714	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Afer_0721	ENOG4105C0H	protease
Afer_0723	ENOG4105C3R	Methionine synthase
Afer_0724	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Afer_0727	ENOG4105KZX	Pterin carbinolamine dehydratase
Afer_0728	ENOG4105D06	uba thif-type nad fad binding protein
Afer_0730	ENOG4108JIK	carboxylase
Afer_0732	ENOG4105C1G	acyl-Coa dehydrogenase
Afer_0733	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
Afer_0735	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
Afer_0739	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
Afer_0740	ENOG41088YA	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity)
Afer_0742	ENOG4108TJN	glycosyl transferase group 1
Afer_0744	ENOG4108TJN	glycosyl transferase group 1
Afer_0745	ENOG4108DMA	Nad-dependent epimerase dehydratase
Afer_0746	ENOG4107RGC	Glycosyl transferase, family 2
Afer_0753	ENOG4105C8Q	Methyl-accepting chemotaxis
Afer_0759	ENOG4107T5V	SNARE associated Golgi
Afer_0760	ENOG4105VPX	protein, conserved in bacteria
Afer_0762	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Afer_0763	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Afer_0765	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
Afer_0766	ENOG4105DFF	Rod shape-determining protein mreb
Afer_0769	ENOG4105CJN	penicillin-binding protein
Afer_0770	ENOG4105C03	ribonuclease
Afer_0771	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Afer_0773	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Afer_0774	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Afer_0777	ENOG4108IV0	ABC, transporter
Afer_0778	ENOG4105C0Z	ABC transporter
Afer_0780	ENOG4105C32	Amino acid ABC transporter (Permease)
Afer_0782	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
Afer_0790	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Afer_0792	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
Afer_0796	ENOG4105C84	Histidine ammonia-lyase
Afer_0798	ENOG4105CEY	Amp-dependent synthetase and ligase
Afer_0799	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
Afer_0804	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
Afer_0805	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Afer_0807	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
Afer_0811	ENOG4105C9K	Endothelin-converting enzyme 1
Afer_0814	ENOG4105E2Q	3-(3-hydroxy-phenyl)propionate hydroxylase
Afer_0815	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Afer_0816	ENOG4105CTK	cobaltochelatase, cobn subunit
Afer_0818	ENOG4105E50	uracil-dna glycosylase
Afer_0820	ENOG4105BZU	Histidine kinase
Afer_0821	ENOG4108IEG	Formate dehydrogenase Alpha subunit
Afer_0824	ENOG4105CPP	Dehydrogenase, E1 component
Afer_0827	ENOG4105CYC	Transferase
Afer_0830	ENOG4108QBV	Monogalactosyldiacylglycerol synthase
Afer_0832	ENOG4108YIQ	Alpha beta hydrolase
Afer_0833	ENOG4105KRM	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
Afer_0834	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
Afer_0835	ENOG4105MC2	DSBA oxidoreductase
Afer_0840	ENOG4105CSR	polyphosphate kinase 2
Afer_0842	ENOG4107QNM	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity)
Afer_0843	ENOG4105E4F	Isochorismate synthase
Afer_0847	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
Afer_0848	ENOG4105CHW	UPF0052 protein
Afer_0849	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
Afer_0850	ENOG4105BZA	Phosphoglycerate kinase
Afer_0851	ENOG4105CP7	Triose-phosphate isomerase
Afer_0856	ENOG41081FY	multiple antibiotic resistance (MarC)-related
Afer_0859	ENOG4105D3R	alkyl hydroperoxide reductase
Afer_0860	ENOG4105DYW	oxidoreductase
Afer_0861	ENOG41076QQ	Glycosyl transferase, family 2
Afer_0863	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
Afer_0864	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
Afer_0865	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Afer_0871	ENOG4105C5F	glutamine synthetase
Afer_0874	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
Afer_0875	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
Afer_0876	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
Afer_0877	ENOG4105CMT	Dihydroxyacetone kinase
Afer_0878	ENOG4108UTZ	Dihydroxyacetone kinase
Afer_0880	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
Afer_0883	ENOG4108ZIA	glycerol-3-phosphate responsive antiterminator
Afer_0885	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Afer_0888	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Afer_0894	ENOG4105DSU	hydrolase
Afer_0895	ENOG4105EIE	fructose-bisphosphate aldolase
Afer_0899	ENOG4108URH	decarboxylase
Afer_0900	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
Afer_0906	ENOG41084T3	4fe-4S ferredoxin iron-sulfur binding domain-containing protein
Afer_0907	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
Afer_0908	ENOG4105E5F	proteasome
Afer_0910	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
Afer_0911	ENOG4105F7N	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
Afer_0912	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
Afer_0913	ENOG4105C3F	Signal peptidase i
Afer_0915	ENOG4105C31	Tryptophanyl-tRNA synthetase
Afer_0916	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
Afer_0917	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
Afer_0919	ENOG4108P8V	Thymidylate synthase complementing protein ThyX
Afer_0922	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Afer_0935	ENOG4108JA0	Oxidoreductase, FAD NAD(P)-binding domain protein
Afer_0937	ENOG4105JNK	Glycosyl transferase (Group 1
Afer_0938	ENOG4108Z1B	Cyclase dehydrase
Afer_0939	ENOG4105CHM	Aminotransferase
Afer_0940	ENOG4105CSW	GntR family transcriptional regulator
Afer_0941	ENOG4105C8Y	Acetylornithine aminotransferase
Afer_0942	ENOG4105C26	Dehydrogenase
Afer_0943	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
Afer_0944	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
Afer_0946	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Afer_0947	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Afer_0948	ENOG4107QTZ	amino acid
Afer_0951	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Afer_0952	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Afer_0954	ENOG4105E2X	shikimate dehydrogenase
Afer_0956	ENOG4105CNI	cell division protein FtsW
Afer_0958	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
Afer_0959	ENOG4108IYU	L-aspartate oxidase
Afer_0960	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
Afer_0962	ENOG4105VFE	sira family
Afer_0968	ENOG4105DF6	Fe-S oxidoreductase
Afer_0969	ENOG4105BZJ	Electron transfer flavoprotein
Afer_0971	ENOG4105DF6	Fe-S oxidoreductase
Afer_0973	ENOG4108UR0	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
Afer_0974	ENOG4105RQ5	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
Afer_0976	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
Afer_0978	ENOG4105DQ6	Transposase
Afer_0979	ENOG4105DQ6	Transposase
Afer_0982	ENOG4105PWE	CRISPR-associated protein cas2
Afer_0983	ENOG4105TZK	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
Afer_0985	ENOG4108VWQ	crispr-associated protein
Afer_0986	ENOG41060M0	Crispr-associated protein, cse4 family
Afer_0992	ENOG4105C2J	ABC transporter
Afer_0995	ENOG4105ETE	Transcriptional regulator (LacI family
Afer_0996	ENOG4105D7K	pfkb domain protein
Afer_0998	ENOG4107QIZ	NADH dehydrogenase
Afer_1002	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
Afer_1004	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
Afer_1006	ENOG4105C9X	ppx gppa phosphatase
Afer_1008	ENOG4107QP8	phosphohexose isomerase
Afer_1009	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Afer_1010	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
Afer_1013	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Afer_1014	ENOG4105C5X	domain protein
Afer_1018	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
Afer_1020	ENOG4105C3J	Cysteine desulfurase
Afer_1021	ENOG4105QAX	Iron-sulfur
Afer_1025	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Afer_1026	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Afer_1027	ENOG4105CEY	Amp-dependent synthetase and ligase
Afer_1028	ENOG4105U5Y	Transcriptional regulator
Afer_1029	ENOG4105C1G	acyl-Coa dehydrogenase
Afer_1031	ENOG4107QX3	carboxylase
Afer_1034	ENOG4105E39	Enoyl-CoA hydratase
Afer_1035	ENOG4105CUB	amino acid
Afer_1038	ENOG4108V1U	phospholipid-binding protein
Afer_1044	ENOG4105CJ1	ABC, transporter
Afer_1053	ENOG4105DF9	Lipoate-protein, ligase
Afer_1057	ENOG4105K6S	Short-chain dehydrogenase reductase Sdr
Afer_1059	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Afer_1060	ENOG4105CDA	abc transporter atp-binding protein
Afer_1075	ENOG4108Z0R	Transferase
Afer_1076	ENOG4105DKW	ABC transporter
Afer_1082	ENOG4105C5X	domain protein
Afer_1085	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
Afer_1086	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Afer_1087	ENOG4105CHR	reductase
Afer_1088	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Afer_1093	ENOG4108J5G	6-phosphogluconate dehydrogenase
Afer_1094	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
Afer_1095	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Afer_1096	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
Afer_1097	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Afer_1098	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Afer_1099	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Afer_1100	ENOG4105BZU	Histidine kinase
Afer_1101	ENOG4105BZU	Histidine kinase
Afer_1102	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
Afer_1104	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Afer_1106	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
Afer_1107	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Afer_1108	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Afer_1109	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Afer_1110	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Afer_1118	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Afer_1119	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Afer_1120	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
Afer_1124	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
Afer_1125	ENOG4108UW8	fha domain-containing protein
Afer_1129	ENOG4107QIV	Cytochrome c biogenesis protein
Afer_1132	ENOG4108Z4T	Peptidase M50
Afer_1133	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Afer_1135	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Afer_1136	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Afer_1137	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Afer_1143	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Afer_1145	ENOG4108KGH	TRANSCRIPTIONal
Afer_1146	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
Afer_1148	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
Afer_1149	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Afer_1151	ENOG4105CEY	Amp-dependent synthetase and ligase
Afer_1153	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Afer_1156	ENOG4105BZU	Histidine kinase
Afer_1159	ENOG4108YYH	Nadph-dependent fmn reductase
Afer_1161	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
Afer_1174	ENOG4105C08	Histidine kinase
Afer_1176	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
Afer_1177	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
Afer_1178	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
Afer_1182	ENOG4105IKQ	hydratase
Afer_1188	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Afer_1190	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
Afer_1191	ENOG4105BZU	Histidine kinase
Afer_1194	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Afer_1196	ENOG4108YZG	isomerase
Afer_1197	ENOG4108VC7	Protein of unknown function (DUF2587)
Afer_1199	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
Afer_1201	ENOG4108V06	Glutathione peroxidase
Afer_1208	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Afer_1210	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
Afer_1212	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Afer_1213	ENOG4107QTZ	amino acid
Afer_1215	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Afer_1216	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Afer_1217	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Afer_1218	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
Afer_1219	ENOG4105CDY	transcriptional regulatory protein
Afer_1220	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
Afer_1221	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
Afer_1223	ENOG4105E2K	Glycosyl transferase (Group 1
Afer_1225	ENOG4108VTU	Cdp-alcohol phosphatidyltransferase
Afer_1229	ENOG4105C22	threonyL-tRNA synthetase
Afer_1230	ENOG4105C8N	cysteinyl-tRNA synthetase
Afer_1234	ENOG4105EUB	pirin domain protein
Afer_1235	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
Afer_1237	ENOG4108VIA	integral membrane protein
Afer_1238	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
Afer_1239	ENOG4105DFA	alanine racemase domain protein
Afer_1240	ENOG41083W3	Multi-copper polyphenol oxidoreductase laccase
Afer_1241	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Afer_1243	ENOG4105D4A	Cell wall formation (By similarity)
Afer_1244	ENOG4105DFU	Cell wall formation (By similarity)
Afer_1245	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Afer_1246	ENOG4105CNI	cell division protein FtsW
Afer_1247	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
Afer_1248	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Afer_1249	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Afer_1250	ENOG4105CJN	penicillin-binding protein
Afer_1252	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
Afer_1253	ENOG4108V6E	Cell division protein mraZ
Afer_1259	ENOG4105D1E	Undecaprenyl pyrophosphate phosphatase
Afer_1261	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
Afer_1262	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Afer_1263	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
Afer_1266	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Afer_1268	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Afer_1270	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Afer_1286	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Afer_1287	ENOG4106HK8	GPR1 FUN34 yaaH family protein
Afer_1293	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Afer_1294	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
Afer_1295	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
Afer_1296	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Afer_1302	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
Afer_1305	ENOG4105K63	Thioredoxin
Afer_1306	ENOG4105CPC	Aldo Keto reductase
Afer_1307	ENOG4105F2Z	3-oxoadipate enol-lactonase
Afer_1308	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
Afer_1310	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Afer_1316	ENOG4105DQ6	Transposase
Afer_1319	ENOG4105DQ6	Transposase
Afer_1322	ENOG4105C8T	Leucyl-tRNA synthetase
Afer_1328	ENOG4105CG3	alpha amylase, catalytic region
Afer_1332	ENOG4105ETE	Transcriptional regulator (LacI family
Afer_1335	ENOG4105D7W	serine acetyltransferase
Afer_1337	ENOG4105CEN	a g-specific adenine glycosylase
Afer_1343	ENOG4105C8Q	Methyl-accepting chemotaxis
Afer_1346	ENOG4107QX3	carboxylase
Afer_1347	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Afer_1349	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
Afer_1350	ENOG4105E9Q	Acyl-transferase
Afer_1352	ENOG4105D0M	Protease HtpX homolog
Afer_1354	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
Afer_1355	ENOG4105KHN	chorismate mutase
Afer_1357	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Afer_1360	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Afer_1361	ENOG4105EU8	FAD linked oxidase domain protein
Afer_1362	ENOG4105CQB	FAD linked oxidase domain protein
Afer_1363	ENOG4105EMU	Dehydrogenase
Afer_1364	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
Afer_1367	ENOG4105CEY	Amp-dependent synthetase and ligase
Afer_1368	ENOG41082VC	UPF0145 protein
Afer_1370	ENOG4105CHU	acetyl-coa acetyltransferase
Afer_1371	ENOG4108ZJI	phenylacetic acid degradation protein
Afer_1373	ENOG4105E39	Enoyl-CoA hydratase
Afer_1374	ENOG4105E39	Enoyl-CoA hydratase
Afer_1375	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Afer_1378	ENOG4105C26	Dehydrogenase
Afer_1383	ENOG4108IJ6	ABC transporter
Afer_1385	ENOG4105BZU	Histidine kinase
Afer_1394	ENOG4107QMH	DNA methylase
Afer_1401	ENOG4105BZU	Histidine kinase
Afer_1402	ENOG4108M8H	domain protein
Afer_1409	ENOG4105FDP	GntR family transcriptional regulator
Afer_1410	ENOG4105ETS	cytosine purines uracil thiamine allantoin
Afer_1414	ENOG4105CGP	Urocanate hydratase
Afer_1415	ENOG4105CI2	imidazolone-5-propionate hydrolase
Afer_1430	ENOG4105QUH	Domain of unknown function (DUF2088)
Afer_1431	ENOG4105CPQ	Dehydrogenase
Afer_1432	ENOG4108RXW	HAD-superfamily subfamily IB hydrolase
Afer_1434	ENOG4107TE1	transport protein
Afer_1438	ENOG4108IG5	Transcriptional regulator
Afer_1439	ENOG4108ZHR	arsR family transcriptional regulator
Afer_1441	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Afer_1442	ENOG4105DMS	mur ligase
Afer_1444	ENOG4105KF3	Short-chain dehydrogenase reductase Sdr
Afer_1447	ENOG4108YV4	Universal stress protein
Afer_1448	ENOG4108N0W	Major Facilitator superfamily
Afer_1450	ENOG4105BZ8	glutamate synthase
Afer_1453	ENOG41090R7	Ferric uptake
Afer_1455	ENOG4105CPC	Aldo Keto reductase
Afer_1457	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Afer_1458	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Afer_1460	ENOG4105C1J	atp-dependent rna helicase
Afer_1462	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
Afer_1463	ENOG4105C3J	Cysteine desulfurase
Afer_1467	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
Afer_1468	ENOG4107QYG	anthranilate phosphoribosyltransferase
Afer_1470	ENOG4105BZU	Histidine kinase
Afer_1471	ENOG4105C1G	acyl-Coa dehydrogenase
Afer_1472	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
Afer_1478	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
Afer_1491	ENOG4105F0N	pyrophosphate phospho-hydrolase
Afer_1492	ENOG41083MR	nifu domain-containing protein
Afer_1495	ENOG4105C28	cystathionine
Afer_1497	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Afer_1498	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Afer_1499	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Afer_1500	ENOG41084QK	UPF0109 protein
Afer_1501	ENOG4105K5M	30s ribosomal protein S16
Afer_1507	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
Afer_1508	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
Afer_1509	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Afer_1510	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Afer_1511	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Afer_1514	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Afer_1515	ENOG4106H78	methyltransferase
Afer_1517	ENOG4105DP4	dak2 domain fusion protein ylov
Afer_1518	ENOG4105VB9	50S ribosomal protein l28
Afer_1519	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
Afer_1522	ENOG4107WI4	Aldose-1-epimerase
Afer_1525	ENOG4105BZU	Histidine kinase
Afer_1526	ENOG4105C1G	acyl-Coa dehydrogenase
Afer_1528	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Afer_1529	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Afer_1532	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
Afer_1533	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Afer_1534	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Afer_1535	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Afer_1536	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Afer_1537	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Afer_1538	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Afer_1542	ENOG4105CEP	NADH dehydrogenase
Afer_1548	ENOG4105C01	Dihydroxy-acid dehydratase
Afer_1549	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Afer_1550	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Afer_1551	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Afer_1553	ENOG4108DT4	serine threonine protein kinase
Afer_1554	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Afer_1555	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Afer_1558	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
Afer_1561	ENOG41080RH	Thioredoxin
Afer_1565	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
Afer_1573	ENOG4105CNN	ABC, transporter
Afer_1574	ENOG4105C2J	ABC transporter
Afer_1575	ENOG4105DFW	ABC transporter
Afer_1579	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
Afer_1589	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Afer_1590	ENOG4108IY2	MazG family
Afer_1595	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Afer_1596	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Afer_1597	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Afer_1599	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Afer_1603	ENOG4105DJG	MaoC domain protein dehydratase
Afer_1606	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Afer_1609	ENOG4105T1M	mycothiol conjugate amidase mca
Afer_1611	ENOG4105C0B	DNA polymerase III (alpha subunit)
Afer_1614	ENOG4108X79	transcriptional regulator
Afer_1624	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
Afer_1625	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
Afer_1628	ENOG4105CEY	Amp-dependent synthetase and ligase
Afer_1630	ENOG4105CHR	reductase
Afer_1635	ENOG4105VT3	DNA binding domain protein, excisionase family
Afer_1640	ENOG4105CVK	Glutamate decarboxylase
Afer_1641	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Afer_1657	ENOG4108VX5	3-methyladenine DNA glycosylase
Afer_1658	ENOG4105CH7	arginosuccinase
Afer_1659	ENOG4105CDH	Citrulline--aspartate ligase
Afer_1661	ENOG4105DBV	ornithine carbamoyltransferase
Afer_1662	ENOG4105C8Y	Acetylornithine aminotransferase
Afer_1664	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
Afer_1665	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Afer_1673	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Afer_1674	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Afer_1675	ENOG4108RWN	rrna methyltransferase
Afer_1676	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Afer_1677	ENOG4105VJV	50s ribosomal protein L35
Afer_1678	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
Afer_1681	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Afer_1682	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
Afer_1683	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
Afer_1684	ENOG4108R6K	riboflavin synthase, subunit alpha
Afer_1685	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
Afer_1687	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Afer_1688	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Afer_1692	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Afer_1694	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
Afer_1695	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Afer_1697	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
Afer_1698	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
Afer_1699	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Afer_1700	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Afer_1701	ENOG4105CD3	dihydroorotase
Afer_1702	ENOG4105CXT	aspartate transcarbamylase
Afer_1703	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Afer_1707	ENOG4105BZ9	Cytochrome C oxidase, subunit I
Afer_1711	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
Afer_1712	ENOG4105DC7	peptidase M24
Afer_1713	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Afer_1714	ENOG4105M7K	Involved in the transcription termination process (By similarity)
Afer_1716	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
Afer_1717	ENOG4105D49	3-dehydroquinate synthase
Afer_1718	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Afer_1721	ENOG41090MY	MarR family Transcriptional regulator
Afer_1723	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
Afer_1726	ENOG4105C4R	Atp-dependent dna helicase
Afer_1727	ENOG4105CGK	Exodeoxyribonuclease III
Afer_1728	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
Afer_1731	ENOG4105BZU	Histidine kinase
Afer_1732	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
Afer_1733	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
Afer_1734	ENOG4105CBD	Diacylglycerol kinase
Afer_1739	ENOG4106YN8	Prenyltransferase
Afer_1740	ENOG4105IQ5	FAD linked oxidase domain protein
Afer_1742	ENOG4105JFG	SpoIID LytB domain protein
Afer_1749	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Afer_1751	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Afer_1752	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
Afer_1754	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Afer_1760	ENOG4107RYD	Part of the ABC transporter FtsEX involved in cellular division (By similarity)
Afer_1761	ENOG4105CAK	Cell division ATP-binding protein ftsE
Afer_1762	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
Afer_1763	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Afer_1765	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
Afer_1766	ENOG41086CI	Bifunctional phosphoglucose phosphomannose isomerase
Afer_1768	ENOG4107QKV	phosphomannomutase
Afer_1770	ENOG4105C1G	acyl-Coa dehydrogenase
Afer_1775	ENOG4105DQ6	Transposase
Afer_1777	ENOG4105CI0	Citrate lyase
Afer_1778	ENOG4105CG3	alpha amylase, catalytic region
Afer_1779	ENOG4105E39	Enoyl-CoA hydratase
Afer_1780	ENOG4105DJT	lAO AO transport system ATPase
Afer_1781	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Afer_1786	ENOG4105C9Q	fumarate hydratase class II
Afer_1790	ENOG4105E5G	Alpha beta hydrolase fold
Afer_1794	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Afer_1795	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
Afer_1797	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
Afer_1798	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Afer_1799	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
Afer_1801	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
Afer_1804	ENOG4105ESV	Glycosyl transferase, family 4
Afer_1805	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Afer_1807	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Afer_1808	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Afer_1810	ENOG41082DI	50s ribosomal protein l31
Afer_1812	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
Afer_1813	ENOG4105D6E	homoserine dehydrogenase
Afer_1814	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
Afer_1815	ENOG4105C75	arginyL-tRNA synthetase
Afer_1816	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Afer_1817	ENOG4108SHN	Glycosyl transferase, family 2
Afer_1818	ENOG4107XFB	conserved TRANSMEMBRANE PROTEIN
Afer_1819	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Afer_1820	ENOG4105CB2	alcohol dehydrogenase
Afer_1824	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
Afer_1826	ENOG4107EUI	c reductase, iron-sulfur
Afer_1830	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
Afer_1832	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
Afer_1834	ENOG4105C29	acyl-CoA thioesterase
Afer_1835	ENOG4105BZN	citrate synthase
Afer_1843	ENOG4107T9V	chlorite dismutase
Afer_1844	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Afer_1846	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Afer_1849	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
Afer_1853	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Afer_1854	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Afer_1857	ENOG4107R5R	arsenical pump membrane protein
Afer_1858	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Afer_1859	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Afer_1869	ENOG4108UUM	single-stranded DNA-binding protein
Afer_1871	ENOG4105DJZ	UPF0182 protein
Afer_1873	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Afer_1874	ENOG4108S8N	class II Aldolase
Afer_1876	ENOG4108US0	Transcription regulator that can specifically activate or repress expression of target genes (By similarity)
Afer_1881	ENOG4108HMX	isocitrate dehydrogenase (NADP)
Afer_1884	ENOG4108ZAF	Molybdopterin
Afer_1886	ENOG4105DFF	Rod shape-determining protein mreb
Afer_1897	ENOG4105ETS	cytosine purines uracil thiamine allantoin
Afer_1900	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
Afer_1901	ENOG4108VJ1	Transcriptional regulator (CarD family
Afer_1902	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
Afer_1903	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Afer_1906	ENOG4105CRK	lysyL-tRNA synthetase
Afer_1907	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Afer_1909	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Afer_1911	ENOG4105EEI	dihydropteroate synthase
Afer_1912	ENOG4105EUJ	GTP cyclohydrolase i
Afer_1913	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Afer_1914	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
Afer_1918	ENOG4105EMN	RNA polymerase sigma factor
Afer_1920	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Afer_1921	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Afer_1922	ENOG4105C0X	amino acid
Afer_1923	ENOG4107VEG	TrkA-N domain protein
Afer_1928	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
Afer_1940	ENOG4105C8N	cysteinyl-tRNA synthetase
Afer_1943	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Afer_1944	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Afer_1952	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
Afer_1953	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
Afer_1956	ENOG4105C83	adenylosuccinate lyase
Afer_1957	ENOG4105C12	Phosphoribosylglycinamide synthetase
Afer_1958	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Afer_1959	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Afer_1960	ENOG4105CFG	Acts as a chaperone (By similarity)
Afer_1962	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Afer_1963	ENOG4105KNI	merR family transcriptional Regulator
Afer_1964	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Afer_1967	ENOG4105C5F	glutamine synthetase
Afer_1974	ENOG4107RGC	Glycosyl transferase, family 2
Afer_1978	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Afer_1979	ENOG4105W8H	transhydrogenase (subunit alpha
Afer_1980	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Afer_1983	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Afer_1984	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Afer_1988	ENOG4105CBC	glutamate synthase
Afer_1991	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Afer_1993	ENOG4105CGY	Dna recombination protein
Afer_1994	ENOG4105KHC	sulfurtransferase
Afer_1995	ENOG4105BZU	Histidine kinase
Afer_1996	ENOG4105KHC	sulfurtransferase
Afer_2002	ENOG4105CQB	FAD linked oxidase domain protein
Afer_2005	ENOG4105C8Q	Methyl-accepting chemotaxis
Afer_2006	ENOG4108NNZ	chitinase
Afer_2012	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
Afer_2014	ENOG4105CMM	transposase
Afer_2018	ENOG4108Z6B	deaminase
Afer_2024	ENOG4108K8U	Glycerol operon regulatory protein
Afer_2025	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Afer_2031	ENOG4107QJE	Chromosome Partitioning Protein
Afer_2033	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Afer_2034	ENOG4108Z7S	Single-stranded nucleic acid binding R3H domain-containing protein
Afer_2036	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Afer_2037	ENOG4108748	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
Afer_2038	ENOG41084CH	50S ribosomal protein l34