locus-tag	class	description
Afer_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Afer_0002	COG0592	DNA-directed DNA polymerase activity
Afer_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Afer_0006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Afer_0008	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
Afer_0020	COG3469	chitinase activity
Afer_0023	COG0617	tRNA 3'-terminal CCA addition
Afer_0024	COG0123	including yeast histone deacetylase and acetoin utilization protein
Afer_0028	COG1307	EDD domain protein, DegV family
Afer_0032	COG3409	Peptidoglycan-binding domain 1 protein
Afer_0032	COG0860	N-Acetylmuramoyl-L-alanine amidase
Afer_0035	COG2267	carboxylic ester hydrolase activity
Afer_0037	COG1260	myo-inositol-1-phosphate synthase
Afer_0040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Afer_0042	COG0359	binds to the 23S rRNA
Afer_0043	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Afer_0051	COG0247	lactate metabolic process
Afer_0051	COG2181	nitrate reductase activity
Afer_0052	COG0717	Belongs to the dCTP deaminase family
Afer_0065	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Afer_0076	COG0076	glutamate decarboxylase activity
Afer_0077	COG0537	adenosine 5'-monophosphoramidase activity
Afer_0079	COG1832	CoA-binding protein
Afer_0080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Afer_0082	COG0124	histidyl-tRNA synthetase
Afer_0084	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Afer_0085	COG0183	Belongs to the thiolase family
Afer_0086	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Afer_0086	COG0512	Glutamine amidotransferase of anthranilate synthase
Afer_0087	COG0515	serine threonine protein kinase
Afer_0088	COG0515	serine threonine protein kinase
Afer_0088	COG2815	serine threonine protein kinase
Afer_0094	COG1012	belongs to the aldehyde dehydrogenase family
Afer_0094	COG2030	dehydratase
Afer_0097	COG0077	Prephenate dehydratase
Afer_0098	COG1691	(AIR) carboxylase
Afer_0099	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Afer_0101	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Afer_0102	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Afer_0103	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Afer_0106	COG0183	Belongs to the thiolase family
Afer_0107	COG0297	glycogen (starch) synthase activity
Afer_0114	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Afer_0119	COG1850	ribulose-bisphosphate carboxylase activity
Afer_0129	COG1192	Involved in chromosome partitioning
Afer_0133	COG3002	Belongs to the UPF0753 family
Afer_0137	COG1766	The M ring may be actively involved in energy transduction
Afer_0140	COG1157	protein secretion by the type III secretion system
Afer_0142	COG1196	nuclear chromosome segregation
Afer_0142	COG0741	lytic transglycosylase activity
Afer_0142	COG0739	heme binding
Afer_0144	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Afer_0145	COG1749	Flagellar hook protein flgE
Afer_0147	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Afer_0148	COG1360	Flagellar Motor Protein
Afer_0153	COG2963	transposase activity
Afer_0154	COG2801	Transposase and inactivated derivatives
Afer_0158	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Afer_0159	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Afer_0162	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Afer_0163	COG0446	pyridine nucleotide-disulphide oxidoreductase
Afer_0164	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Afer_0165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Afer_0167	COG0572	uridine kinase
Afer_0168	COG1285	pathogenesis
Afer_0171	COG4166	transmembrane transport
Afer_0173	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Afer_0174	COG0444	Belongs to the ABC transporter superfamily
Afer_0176	COG0583	DNA-binding transcription factor activity
Afer_0177	COG3588	fructose-bisphosphate aldolase
Afer_0180	COG2197	response regulator
Afer_0183	COG1652	LysM domain
Afer_0188	COG2009	succinate dehydrogenase
Afer_0190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Afer_0198	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Afer_0200	COG0745	RESPONSE REGULATOR receiver
Afer_0201	COG5002	protein histidine kinase activity
Afer_0208	COG4786	Flagellar basal body rod
Afer_0210	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Afer_0211	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Afer_0212	COG2198	Histidine kinase
Afer_0212	COG0643	Histidine kinase
Afer_0213	COG0835	chemotaxis
Afer_0214	COG2201	protein-glutamate methylesterase activity
Afer_0222	COG1250	3-hydroxyacyl-CoA dehydrogenase
Afer_0225	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Afer_0231	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Afer_0240	COG0316	Belongs to the HesB IscA family
Afer_0241	COG0745	RESPONSE REGULATOR receiver
Afer_0242	COG0174	glutamine synthetase
Afer_0246	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Afer_0246	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Afer_0249	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Afer_0250	COG0181	hydroxymethylbilane synthase activity
Afer_0253	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Afer_0254	COG0038	chloride channel
Afer_0257	COG1028	Short-chain dehydrogenase reductase Sdr
Afer_0266	COG0667	Aldo Keto reductase
Afer_0269	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Afer_0270	COG1132	(ABC) transporter
Afer_0271	COG0778	Nitroreductase
Afer_0272	COG2902	Dehydrogenase
Afer_0284	COG1289	transmembrane transporter activity
Afer_0285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Afer_0286	COG0513	Belongs to the DEAD box helicase family
Afer_0289	COG1024	Enoyl-CoA hydratase
Afer_0291	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Afer_0295	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Afer_0296	COG0393	Putative heavy-metal-binding
Afer_0297	COG2814	Major facilitator Superfamily
Afer_0301	COG2801	Transposase and inactivated derivatives
Afer_0302	COG2963	transposase activity
Afer_0305	COG1960	acyl-CoA dehydrogenase activity
Afer_0306	COG0215	cysteine-tRNA ligase activity
Afer_0307	COG0525	valine-tRNA ligase activity
Afer_0308	COG1914	H( )-stimulated, divalent metal cation uptake system
Afer_0309	COG0640	Transcriptional regulator
Afer_0312	COG1053	succinate dehydrogenase
Afer_0313	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Afer_0318	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Afer_0319	COG0045	succinate-CoA ligase (ADP-forming) activity
Afer_0320	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Afer_0322	COG0138	bifunctional purine biosynthesis protein purh
Afer_0323	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Afer_0324	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Afer_0325	COG2814	Major facilitator Superfamily
Afer_0330	COG1309	transcriptional regulator
Afer_0332	COG1131	(ABC) transporter
Afer_0334	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Afer_0336	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Afer_0337	COG1138	Cytochrome C-type biogenesis protein
Afer_0338	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Afer_0339	COG3088	subunit of a heme lyase
Afer_0340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Afer_0341	COG0477	Major facilitator Superfamily
Afer_0342	COG2197	response regulator
Afer_0345	COG1131	(ABC) transporter
Afer_0347	COG2151	metal-sulfur cluster biosynthetic enzyme
Afer_0347	COG0489	protein tyrosine kinase activity
Afer_0353	COG2086	electron transfer activity
Afer_0354	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Afer_0357	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Afer_0358	COG0297	glycogen (starch) synthase activity
Afer_0361	COG0438	transferase activity, transferring glycosyl groups
Afer_0362	COG0644	oxidoreductase
Afer_0363	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Afer_0364	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Afer_0365	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Afer_0366	COG0649	NAD binding
Afer_0369	COG1034	ATP synthesis coupled electron transport
Afer_0370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Afer_0371	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Afer_0372	COG0839	Belongs to the complex I subunit 6 family
Afer_0373	COG0713	ATP synthesis coupled electron transport
Afer_0374	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Afer_0376	COG1007	ATP synthesis coupled electron transport
Afer_0378	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Afer_0378	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Afer_0379	COG1666	GTP binding
Afer_0382	COG1247	-acetyltransferase
Afer_0383	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Afer_0386	COG0250	Participates in transcription elongation, termination and antitermination
Afer_0387	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Afer_0388	COG0081	regulation of translation
Afer_0389	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Afer_0390	COG0222	ribosome binding
Afer_0391	COG0085	RNA polymerase activity
Afer_0392	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Afer_0393	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Afer_0394	COG0049	tRNA binding
Afer_0395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Afer_0396	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Afer_0397	COG0051	transcription antitermination factor activity, RNA binding
Afer_0398	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Afer_0400	COG0089	rRNA binding
Afer_0401	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Afer_0402	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Afer_0403	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Afer_0405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Afer_0406	COG0255	Belongs to the universal ribosomal protein uL29 family
Afer_0407	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Afer_0408	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Afer_0409	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Afer_0410	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Afer_0411	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Afer_0412	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Afer_0413	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Afer_0414	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Afer_0415	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Afer_0416	COG1841	ribosomal large subunit assembly
Afer_0417	COG0200	Binds to the 23S rRNA
Afer_0419	COG0563	adenylate kinase activity
Afer_0421	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Afer_0422	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Afer_0423	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Afer_0424	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Afer_0425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Afer_0427	COG0203	ribosomal protein L17
Afer_0428	COG0101	tRNA pseudouridine synthase activity
Afer_0429	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Afer_0430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Afer_0431	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Afer_0432	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Afer_0434	COG0583	DNA-binding transcription factor activity
Afer_0435	COG0736	holo-[acyl-carrier-protein] synthase activity
Afer_0436	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Afer_0436	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Afer_0437	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Afer_0438	COG1573	uracil-dna glycosylase
Afer_0441	COG0456	acetyltransferase
Afer_0442	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Afer_0443	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Afer_0444	COG0459	protein refolding
Afer_0453	COG0494	nUDIX hydrolase
Afer_0455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Afer_0459	COG0516	GMP reductase activity
Afer_0460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Afer_0460	COG0519	Catalyzes the synthesis of GMP from XMP
Afer_0471	COG0142	geranyltranstransferase activity
Afer_0472	COG0312	modulator of DNA gyrase
Afer_0475	COG2239	Acts as a magnesium transporter
Afer_0476	COG1914	H( )-stimulated, divalent metal cation uptake system
Afer_0477	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Afer_0478	COG2135	peptidase activity
Afer_0486	COG0303	'Molybdopterin
Afer_0487	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Afer_0489	COG0438	transferase activity, transferring glycosyl groups
Afer_0490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Afer_0494	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Afer_0495	COG3387	PFAM Glycoside hydrolase 15-related
Afer_0497	COG1940	carbohydrate kinase activity
Afer_0498	COG2814	Major facilitator Superfamily
Afer_0504	COG0410	ABC transporter
Afer_0508	COG4565	transcriptional regulatory protein
Afer_0511	COG3290	protein histidine kinase activity
Afer_0519	COG2801	Transposase and inactivated derivatives
Afer_0522	COG1132	(ABC) transporter
Afer_0523	COG4988	ABC transporter
Afer_0524	COG1294	oxidase, subunit
Afer_0525	COG1271	oxidase subunit
Afer_0526	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Afer_0527	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Afer_0528	COG0084	hydrolase, TatD family'
Afer_0529	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Afer_0530	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Afer_0532	COG0012	GTP binding
Afer_0534	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Afer_0537	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Afer_0540	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Afer_0543	COG0719	Fe-S assembly protein
Afer_0550	COG2963	transposase activity
Afer_0557	COG2205	protein histidine kinase activity
Afer_0558	COG0745	RESPONSE REGULATOR receiver
Afer_0559	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Afer_0560	COG1024	Enoyl-CoA hydratase
Afer_0561	COG0719	Fe-S assembly protein
Afer_0562	COG2146	nitrite reductase [NAD(P)H] activity
Afer_0563	COG0396	ATPase activity
Afer_0566	COG0396	ATPase activity
Afer_0567	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Afer_0568	COG0822	iron-sulfur transferase activity
Afer_0572	COG1929	Belongs to the glycerate kinase type-1 family
Afer_0573	COG1012	belongs to the aldehyde dehydrogenase family
Afer_0575	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Afer_0582	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Afer_0586	COG2409	Drug exporters of the RND superfamily
Afer_0587	COG1024	Enoyl-CoA hydratase
Afer_0588	COG0318	PFAM AMP-dependent synthetase and ligase
Afer_0589	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Afer_0591	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Afer_0598	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Afer_0599	COG1181	Belongs to the D-alanine--D-alanine ligase family
Afer_0602	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Afer_0603	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Afer_0605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Afer_0608	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Afer_0609	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Afer_0617	COG0483	inositol monophosphate 1-phosphatase activity
Afer_0621	COG0697	spore germination
Afer_0624	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Afer_0625	COG1191	sigma factor activity
Afer_0626	COG0052	Belongs to the universal ribosomal protein uS2 family
Afer_0627	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Afer_0628	COG0528	UMP kinase activity
Afer_0629	COG0233	cytoplasmic translational termination
Afer_0630	COG4589	Belongs to the CDS family
Afer_0631	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Afer_0632	COG0750	zinc metalloprotease
Afer_0633	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Afer_0634	COG0442	prolyl-tRNA aminoacylation
Afer_0635	COG0779	Required for maturation of 30S ribosomal subunits
Afer_0636	COG0195	Participates in both transcription termination and antitermination
Afer_0638	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Afer_0639	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Afer_0640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Afer_0642	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Afer_0643	COG1185	polyribonucleotide nucleotidyltransferase activity
Afer_0646	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Afer_0647	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Afer_0648	COG1674	ftsk spoiiie
Afer_0649	COG1686	Belongs to the peptidase S11 family
Afer_0650	COG0083	homoserine kinase activity
Afer_0651	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Afer_0652	COG1058	Belongs to the CinA family
Afer_0652	COG1546	Belongs to the CinA family
Afer_0653	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Afer_0657	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Afer_0658	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Afer_0660	COG2171	N-acyltransferase activity
Afer_0666	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Afer_0669	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Afer_0680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Afer_0686	COG5522	Integral membrane protein (intg_mem_TP0381)
Afer_0687	COG2801	Transposase and inactivated derivatives
Afer_0692	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Afer_0693	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Afer_0698	COG0686	Belongs to the AlaDH PNT family
Afer_0699	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Afer_0703	COG0745	RESPONSE REGULATOR receiver
Afer_0705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Afer_0709	COG0189	ligase activity
Afer_0711	COG0352	thiamine-phosphate diphosphorylase activity
Afer_0713	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Afer_0714	COG0328	RNA-DNA hybrid ribonuclease activity
Afer_0717	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Afer_0718	COG0508	dehydrogenase complex catalyzes the overall conversion of
Afer_0721	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Afer_0723	COG0646	methionine synthase
Afer_0723	COG1410	methionine synthase
Afer_0724	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Afer_0727	COG2154	pterin-4-alpha-carbinolamine dehydratase
Afer_0728	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Afer_0730	COG4770	biotin carboxylase activity
Afer_0732	COG1960	acyl-CoA dehydrogenase activity
Afer_0735	COG1091	dTDP-4-dehydrorhamnose reductase activity
Afer_0739	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Afer_0740	COG0778	Nitroreductase
Afer_0740	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Afer_0753	COG0840	transmembrane signaling receptor activity
Afer_0759	COG0586	Pfam SNARE associated Golgi protein
Afer_0760	COG1937	Protein conserved in bacteria
Afer_0762	COG0740	serine-type endopeptidase activity
Afer_0763	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Afer_0765	COG0105	UTP biosynthetic process
Afer_0766	COG1077	Cell shape determining protein MreB Mrl
Afer_0770	COG1530	ribonuclease E activity
Afer_0771	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Afer_0772	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Afer_0773	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Afer_0774	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Afer_0776	COG2318	DinB family
Afer_0780	COG0559	Belongs to the binding-protein-dependent transport system permease family
Afer_0782	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Afer_0790	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Afer_0792	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Afer_0796	COG2986	histidine ammonia-lyase
Afer_0798	COG0318	PFAM AMP-dependent synthetase and ligase
Afer_0804	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Afer_0805	COG1797	cobyrinic acid a,c-diamide synthase activity
Afer_0807	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Afer_0811	COG3590	peptidase
Afer_0814	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Afer_0815	COG1492	cobalamin metabolic process
Afer_0818	COG1573	uracil-dna glycosylase
Afer_0820	COG3300	MHYT domain
Afer_0820	COG5001	Diguanylate cyclase
Afer_0821	COG3383	formate dehydrogenase (NAD+) activity
Afer_0824	COG0022	dehydrogenase e1 component
Afer_0827	COG0427	acetyl-CoA hydrolase
Afer_0832	COG0596	Alpha beta hydrolase
Afer_0834	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Afer_0835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Afer_0840	COG2326	polyphosphate kinase activity
Afer_0842	COG2226	methyltransferase
Afer_0843	COG1169	isochorismate synthase
Afer_0846	COG2226	methyltransferase
Afer_0847	COG1660	Displays ATPase and GTPase activities
Afer_0848	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Afer_0849	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Afer_0850	COG0126	phosphoglycerate kinase activity
Afer_0851	COG0149	triose-phosphate isomerase activity
Afer_0852	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Afer_0856	COG2095	MarC family integral membrane protein
Afer_0859	COG0450	alkyl hydroperoxide reductase
Afer_0860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Afer_0861	COG0463	Glycosyl transferase, family 2
Afer_0863	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Afer_0864	COG0463	Glycosyl transferase, family 2
Afer_0865	COG0756	dUTP diphosphatase activity
Afer_0870	COG0515	serine threonine protein kinase
Afer_0874	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Afer_0876	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Afer_0877	COG2376	Dihydroxyacetone kinase
Afer_0878	COG1461	Dihydroxyacetone kinase
Afer_0880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Afer_0883	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Afer_0885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Afer_0888	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Afer_0894	COG0647	UMP catabolic process
Afer_0895	COG1830	Aldolase
Afer_0899	COG1611	Belongs to the LOG family
Afer_0900	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Afer_0901	COG0363	glucosamine-6-phosphate deaminase activity
Afer_0906	COG1141	Ferredoxin
Afer_0907	COG1222	aaa ATPase
Afer_0908	COG4122	O-methyltransferase activity
Afer_0910	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Afer_0911	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Afer_0912	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Afer_0915	COG0180	Tryptophanyl-tRNA synthetase
Afer_0916	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Afer_0917	COG0805	protein transport
Afer_0922	COG1051	belongs to the nudix hydrolase family
Afer_0935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Afer_0937	COG0438	transferase activity, transferring glycosyl groups
Afer_0939	COG0436	Aminotransferase
Afer_0943	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Afer_0944	COG0343	queuine tRNA-ribosyltransferase activity
Afer_0946	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Afer_0947	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Afer_0948	COG0531	amino acid
Afer_0951	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Afer_0952	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Afer_0954	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Afer_0956	COG0772	Belongs to the SEDS family
Afer_0959	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Afer_0960	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Afer_0962	COG0425	Belongs to the sulfur carrier protein TusA family
Afer_0968	COG2181	nitrate reductase activity
Afer_0968	COG0247	lactate metabolic process
Afer_0969	COG2086	electron transfer activity
Afer_0971	COG2181	nitrate reductase activity
Afer_0971	COG0247	lactate metabolic process
Afer_0973	COG0509	glycine decarboxylation via glycine cleavage system
Afer_0974	COG0509	glycine decarboxylation via glycine cleavage system
Afer_0976	COG2210	Belongs to the sulfur carrier protein TusA family
Afer_0978	COG2801	Transposase and inactivated derivatives
Afer_0979	COG2801	Transposase and inactivated derivatives
Afer_0980	COG2963	transposase activity
Afer_0981	COG2963	transposase activity
Afer_0982	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Afer_0983	COG1518	maintenance of DNA repeat elements
Afer_0986	COG1857	crispr-associated protein
Afer_0993	COG1172	Belongs to the binding-protein-dependent transport system permease family
Afer_0995	COG1609	Transcriptional regulator
Afer_0996	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Afer_0998	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Afer_1002	COG0095	Lipoate-protein ligase
Afer_1004	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Afer_1006	COG0248	Ppx GppA phosphatase
Afer_1009	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Afer_1010	COG0604	alcohol dehydrogenase
Afer_1013	COG0556	nucleotide-excision repair
Afer_1014	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Afer_1018	COG1088	dTDP-glucose 4,6-dehydratase activity
Afer_1020	COG0243	molybdopterin cofactor binding
Afer_1021	COG0437	4 iron, 4 sulfur cluster binding
Afer_1025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Afer_1026	COG0446	pyridine nucleotide-disulphide oxidoreductase
Afer_1027	COG0318	PFAM AMP-dependent synthetase and ligase
Afer_1028	COG1309	transcriptional regulator
Afer_1029	COG1960	acyl-CoA dehydrogenase activity
Afer_1031	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Afer_1034	COG1024	Enoyl-CoA hydratase
Afer_1035	COG0531	amino acid
Afer_1051	COG2801	Transposase and inactivated derivatives
Afer_1053	COG0095	Lipoate-protein ligase
Afer_1057	COG1028	Short-chain dehydrogenase reductase Sdr
Afer_1059	COG1136	(ABC) transporter
Afer_1060	COG1126	abc transporter atp-binding protein
Afer_1070	COG1446	asparaginase
Afer_1075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Afer_1076	COG1119	ATPase activity
Afer_1082	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Afer_1085	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Afer_1086	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Afer_1087	COG1028	Short-chain dehydrogenase reductase Sdr
Afer_1089	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Afer_1093	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Afer_1094	COG0159	tryptophan synthase activity
Afer_1095	COG0133	tryptophan synthase activity
Afer_1096	COG0135	phosphoribosylanthranilate isomerase activity
Afer_1097	COG0134	indole-3-glycerol-phosphate synthase activity
Afer_1099	COG0745	RESPONSE REGULATOR receiver
Afer_1100	COG5002	protein histidine kinase activity
Afer_1101	COG3300	MHYT domain
Afer_1101	COG5001	Diguanylate cyclase
Afer_1104	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Afer_1106	COG0107	imidazoleglycerol-phosphate synthase activity
Afer_1107	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Afer_1108	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Afer_1109	COG0131	Imidazoleglycerol-phosphate dehydratase
Afer_1110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Afer_1111	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Afer_1118	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Afer_1119	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Afer_1120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Afer_1123	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Afer_1124	COG0509	glycine decarboxylation via glycine cleavage system
Afer_1125	COG1716	ATPase activity
Afer_1129	COG0785	Cytochrome C biogenesis protein
Afer_1132	COG1994	Peptidase M50
Afer_1133	COG4974	Belongs to the 'phage' integrase family
Afer_1135	COG0504	CTP synthase activity
Afer_1136	COG0497	DNA recombination
Afer_1137	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Afer_1142	COG0601	transmembrane transport
Afer_1145	COG1316	TRANSCRIPTIONal
Afer_1146	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Afer_1148	COG0535	radical SAM domain protein
Afer_1149	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Afer_1151	COG0318	PFAM AMP-dependent synthetase and ligase
Afer_1152	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Afer_1152	COG2022	thiamine diphosphate biosynthetic process
Afer_1155	COG0351	phosphomethylpyrimidine kinase
Afer_1156	COG5001	Diguanylate cyclase
Afer_1156	COG3300	MHYT domain
Afer_1174	COG2205	protein histidine kinase activity
Afer_1176	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Afer_1178	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Afer_1182	COG3971	2-oxopent-4-enoate hydratase activity
Afer_1188	COG1570	exodeoxyribonuclease VII activity
Afer_1190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Afer_1191	COG3300	MHYT domain
Afer_1191	COG5001	Diguanylate cyclase
Afer_1194	COG0154	amidase activity
Afer_1196	COG0698	ribose 5-phosphate isomerase
Afer_1199	COG1959	2 iron, 2 sulfur cluster binding
Afer_1201	COG0386	Belongs to the glutathione peroxidase family
Afer_1208	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Afer_1210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Afer_1212	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Afer_1213	COG0531	amino acid
Afer_1215	COG2255	four-way junction helicase activity
Afer_1216	COG0632	four-way junction helicase activity
Afer_1217	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Afer_1218	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Afer_1219	COG0217	transcriptional regulatory protein
Afer_1220	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Afer_1221	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Afer_1223	COG0438	transferase activity, transferring glycosyl groups
Afer_1229	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Afer_1230	COG0215	cysteine-tRNA ligase activity
Afer_1235	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Afer_1237	COG0762	integral membrane protein
Afer_1238	COG1799	cell septum assembly
Afer_1241	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Afer_1243	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Afer_1244	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Afer_1245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Afer_1246	COG0772	Belongs to the SEDS family
Afer_1247	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Afer_1248	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Afer_1249	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Afer_1250	COG0768	penicillin binding
Afer_1252	COG0275	rRNA processing
Afer_1253	COG2001	Belongs to the MraZ family
Afer_1259	COG0671	phosphoesterase, PA-phosphatase related
Afer_1261	COG0358	DNA primase activity
Afer_1262	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Afer_1262	COG0574	Belongs to the PEP-utilizing enzyme family
Afer_1263	COG0423	glycine-tRNA ligase activity
Afer_1266	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Afer_1267	COG4044	May play a role in the intracellular transport of hydrophobic ligands
Afer_1268	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Afer_1270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Afer_1286	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Afer_1287	COG1584	GPR1 FUN34 yaaH family protein
Afer_1293	COG0484	heat shock protein binding
Afer_1294	COG1420	regulation of RNA biosynthetic process
Afer_1295	COG0268	Binds directly to 16S ribosomal RNA
Afer_1296	COG0481	GTPase activity
Afer_1302	COG0415	Belongs to the DNA photolyase family
Afer_1305	COG3118	belongs to the thioredoxin family
Afer_1306	COG0667	Aldo Keto reductase
Afer_1307	COG0596	Alpha beta hydrolase
Afer_1308	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Afer_1310	COG0577	efflux transmembrane transporter activity
Afer_1310	COG1136	(ABC) transporter
Afer_1315	COG2963	transposase activity
Afer_1316	COG2801	Transposase and inactivated derivatives
Afer_1319	COG2801	Transposase and inactivated derivatives
Afer_1320	COG2963	transposase activity
Afer_1322	COG0495	leucyl-tRNA aminoacylation
Afer_1328	COG0366	Alpha amylase catalytic
Afer_1335	COG1045	serine acetyltransferase
Afer_1337	COG1194	a g-specific adenine glycosylase
Afer_1346	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Afer_1347	COG1160	GTP binding
Afer_1349	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Afer_1352	COG0501	Belongs to the peptidase M48B family
Afer_1354	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Afer_1357	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Afer_1360	COG0247	lactate metabolic process
Afer_1361	COG0277	FAD linked oxidase domain protein
Afer_1362	COG0277	FAD linked oxidase domain protein
Afer_1363	COG4221	oxidoreductase activity
Afer_1364	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Afer_1367	COG0318	PFAM AMP-dependent synthetase and ligase
Afer_1368	COG0393	Putative heavy-metal-binding
Afer_1370	COG0183	Belongs to the thiolase family
Afer_1371	COG2050	protein possibly involved in aromatic compounds catabolism
Afer_1373	COG1024	Enoyl-CoA hydratase
Afer_1374	COG1024	Enoyl-CoA hydratase
Afer_1375	COG1250	3-hydroxyacyl-CoA dehydrogenase
Afer_1378	COG0506	proline dehydrogenase activity
Afer_1378	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Afer_1378	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Afer_1383	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Afer_1401	COG2200	EAL domain
Afer_1402	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Afer_1408	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Afer_1409	COG2188	Transcriptional regulator
Afer_1410	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Afer_1412	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Afer_1414	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Afer_1415	COG1228	amidohydrolase
Afer_1430	COG3875	lactate racemase activity
Afer_1431	COG1063	alcohol dehydrogenase
Afer_1432	COG0560	Phosphoserine phosphatase
Afer_1434	COG2271	Major facilitator Superfamily
Afer_1437	COG0477	Major facilitator Superfamily
Afer_1439	COG0640	Transcriptional regulator
Afer_1441	COG1492	cobalamin metabolic process
Afer_1442	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Afer_1444	COG1028	Short-chain dehydrogenase reductase Sdr
Afer_1447	COG0589	response to stress
Afer_1448	COG2814	Major facilitator Superfamily
Afer_1455	COG0667	Aldo Keto reductase
Afer_1457	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Afer_1458	COG0154	amidase activity
Afer_1460	COG0513	Belongs to the DEAD box helicase family
Afer_1461	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Afer_1462	COG0456	acetyltransferase
Afer_1463	COG1104	cysteine desulfurase activity
Afer_1468	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Afer_1470	COG5001	Diguanylate cyclase
Afer_1470	COG5002	protein histidine kinase activity
Afer_1471	COG1960	acyl-CoA dehydrogenase activity
Afer_1472	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Afer_1478	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Afer_1490	COG2814	Major facilitator Superfamily
Afer_1491	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Afer_1495	COG0626	cystathionine gamma-synthase activity
Afer_1497	COG0335	large ribosomal subunit rRNA binding
Afer_1498	COG0336	Belongs to the RNA methyltransferase TrmD family
Afer_1499	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Afer_1500	COG1837	Belongs to the UPF0109 family
Afer_1501	COG0228	four-way junction DNA binding
Afer_1507	COG1196	nuclear chromosome segregation
Afer_1508	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Afer_1509	COG0571	ribonuclease III activity
Afer_1510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Afer_1514	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Afer_1515	COG0742	ribosomal rna small subunit methyltransferase
Afer_1516	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Afer_1517	COG1461	Dihydroxyacetone kinase
Afer_1518	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Afer_1522	COG2017	converts alpha-aldose to the beta-anomer
Afer_1526	COG1960	acyl-CoA dehydrogenase activity
Afer_1528	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Afer_1529	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Afer_1531	COG0436	Aminotransferase
Afer_1532	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Afer_1533	COG0066	3-isopropylmalate dehydratase activity
Afer_1534	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Afer_1535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Afer_1536	COG0473	3-isopropylmalate dehydrogenase activity
Afer_1538	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Afer_1542	COG1252	NADH dehydrogenase
Afer_1545	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Afer_1548	COG0129	dihydroxy-acid dehydratase activity
Afer_1549	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Afer_1550	COG0154	amidase activity
Afer_1551	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Afer_1553	COG0515	serine threonine protein kinase
Afer_1553	COG2815	serine threonine protein kinase
Afer_1554	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Afer_1555	COG0482	sulfurtransferase activity
Afer_1558	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Afer_1561	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Afer_1565	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Afer_1565	COG3608	succinylglutamate desuccinylase aspartoacylase
Afer_1573	COG1172	Belongs to the binding-protein-dependent transport system permease family
Afer_1575	COG4213	ABC transporter substrate-binding protein
Afer_1577	COG1129	ABC transporter
Afer_1579	COG1074	ATP-dependent DNA helicase activity
Afer_1589	COG0148	phosphopyruvate hydratase activity
Afer_1590	COG3956	TIGRFAM MazG family protein
Afer_1595	COG0193	aminoacyl-tRNA hydrolase activity
Afer_1596	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Afer_1597	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Afer_1599	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Afer_1601	COG0028	Belongs to the TPP enzyme family
Afer_1603	COG2030	dehydratase
Afer_1606	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Afer_1609	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Afer_1611	COG0587	DNA-directed DNA polymerase activity
Afer_1624	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Afer_1625	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Afer_1628	COG0318	PFAM AMP-dependent synthetase and ligase
Afer_1630	COG1028	Short-chain dehydrogenase reductase Sdr
Afer_1635	COG3311	Transcriptional regulator
Afer_1636	COG1569	PIN domain
Afer_1640	COG0076	glutamate decarboxylase activity
Afer_1641	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Afer_1646	COG0697	spore germination
Afer_1657	COG2094	Belongs to the DNA glycosylase MPG family
Afer_1658	COG0165	Argininosuccinate lyase
Afer_1659	COG0137	argininosuccinate synthase activity
Afer_1661	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Afer_1662	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Afer_1664	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Afer_1665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Afer_1670	COG1305	Transglutaminase-like
Afer_1672	COG0730	response to heat
Afer_1673	COG0072	phenylalanine-tRNA ligase activity
Afer_1674	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Afer_1675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Afer_1676	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Afer_1677	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Afer_1678	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Afer_1681	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Afer_1683	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Afer_1683	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Afer_1684	COG0307	riboflavin synthase, alpha
Afer_1687	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Afer_1688	COG0242	peptide deformylase activity
Afer_1692	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Afer_1694	COG1758	RNA polymerase activity
Afer_1695	COG0194	GDP metabolic process
Afer_1697	COG0284	orotidine-5'-phosphate decarboxylase activity
Afer_1698	COG0167	dihydroorotate dehydrogenase activity
Afer_1699	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Afer_1700	COG0505	Belongs to the CarA family
Afer_1701	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Afer_1702	COG0540	Belongs to the ATCase OTCase family
Afer_1703	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Afer_1707	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Afer_1711	COG0109	protoheme IX farnesyltransferase activity
Afer_1712	COG0006	proline dipeptidase activity
Afer_1713	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Afer_1716	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Afer_1718	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Afer_1721	COG1846	Transcriptional regulator
Afer_1723	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Afer_1724	COG1181	Belongs to the D-alanine--D-alanine ligase family
Afer_1726	COG0210	DNA helicase
Afer_1727	COG0708	Exodeoxyribonuclease III
Afer_1728	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Afer_1731	COG2200	EAL domain
Afer_1731	COG2202	Pas domain
Afer_1731	COG2199	diguanylate cyclase activity
Afer_1732	COG0508	dehydrogenase complex catalyzes the overall conversion of
Afer_1732	COG0567	Dehydrogenase, E1 component
Afer_1733	COG2267	carboxylic ester hydrolase activity
Afer_1734	COG1597	lipid kinase activity
Afer_1737	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Afer_1739	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Afer_1740	COG0277	FAD linked oxidase domain protein
Afer_1742	COG2385	sporulation resulting in formation of a cellular spore
Afer_1749	COG0740	serine-type endopeptidase activity
Afer_1750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Afer_1751	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Afer_1752	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Afer_1754	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Afer_1760	COG2177	Part of the ABC transporter FtsEX involved in
Afer_1761	COG2884	Cell division ATP-binding protein ftsE
Afer_1762	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Afer_1763	COG0653	protein targeting
Afer_1765	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Afer_1766	COG2222	sugar isomerase
Afer_1768	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Afer_1775	COG2801	Transposase and inactivated derivatives
Afer_1778	COG0366	Alpha amylase catalytic
Afer_1779	COG1024	Enoyl-CoA hydratase
Afer_1780	COG1703	isobutyryl-CoA mutase activity
Afer_1781	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Afer_1786	COG0114	fumarate hydratase activity
Afer_1787	COG0604	alcohol dehydrogenase
Afer_1787	COG1028	Short-chain dehydrogenase reductase Sdr
Afer_1787	COG3321	synthase
Afer_1790	COG2267	carboxylic ester hydrolase activity
Afer_1794	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Afer_1795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Afer_1797	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Afer_1798	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Afer_1799	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Afer_1801	COG0356	it plays a direct role in the translocation of protons across the membrane
Afer_1804	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Afer_1805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Afer_1807	COG2890	protein-(glutamine-N5) methyltransferase activity
Afer_1808	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Afer_1810	COG0254	rRNA binding
Afer_1812	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Afer_1813	COG0460	homoserine dehydrogenase
Afer_1814	COG0019	diaminopimelate decarboxylase activity
Afer_1815	COG0018	arginyl-trna synthetase
Afer_1816	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Afer_1817	COG1215	transferase activity, transferring glycosyl groups
Afer_1818	COG0586	Pfam SNARE associated Golgi protein
Afer_1819	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Afer_1820	COG0604	alcohol dehydrogenase
Afer_1824	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Afer_1826	COG0723	plastoquinol--plastocyanin reductase activity
Afer_1830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Afer_1832	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Afer_1834	COG1946	Acyl-CoA thioesterase
Afer_1835	COG0372	Belongs to the citrate synthase family
Afer_1838	COG1051	belongs to the nudix hydrolase family
Afer_1844	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Afer_1846	COG0459	protein refolding
Afer_1847	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Afer_1849	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Afer_1853	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Afer_1854	COG0315	cyclic pyranopterin monophosphate synthase activity
Afer_1857	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Afer_1858	COG0446	pyridine nucleotide-disulphide oxidoreductase
Afer_1859	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Afer_1871	COG1615	UPF0182 protein
Afer_1873	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Afer_1874	COG0235	Class ii aldolase
Afer_1876	COG1846	Transcriptional regulator
Afer_1881	COG0538	isocitrate dehydrogenase activity
Afer_1884	COG0314	molybdopterin synthase activity
Afer_1886	COG1077	Cell shape determining protein MreB Mrl
Afer_1897	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Afer_1900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Afer_1900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Afer_1901	COG1329	Transcriptional regulator
Afer_1902	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Afer_1903	COG0542	response to heat
Afer_1906	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Afer_1907	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Afer_1909	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Afer_1911	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Afer_1912	COG0302	gtp cyclohydrolase
Afer_1914	COG0037	tRNA processing
Afer_1918	COG1595	DNA-templated transcription, initiation
Afer_1920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Afer_1921	COG1754	DNA topoisomerase type I activity
Afer_1921	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Afer_1922	COG0531	amino acid
Afer_1923	COG0569	domain protein
Afer_1928	COG3384	dioxygenase
Afer_1940	COG0215	cysteine-tRNA ligase activity
Afer_1943	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Afer_1944	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Afer_1952	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Afer_1953	COG0047	phosphoribosylformylglycinamidine synthase activity
Afer_1956	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Afer_1957	COG0151	Belongs to the GarS family
Afer_1958	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Afer_1959	COG0588	phosphoglycerate mutase activity
Afer_1960	COG0443	Heat shock 70 kDa protein
Afer_1962	COG0484	heat shock protein binding
Afer_1963	COG0789	Transcriptional regulator
Afer_1964	COG0542	response to heat
Afer_1967	COG0174	glutamine synthetase
Afer_1971	COG1216	Glycosyl transferase, family 2
Afer_1971	COG0438	transferase activity, transferring glycosyl groups
Afer_1978	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Afer_1979	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Afer_1980	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Afer_1983	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Afer_1984	COG0473	3-isopropylmalate dehydrogenase activity
Afer_1988	COG0070	glutamate synthase
Afer_1988	COG0069	glutamate synthase activity
Afer_1988	COG0067	glutamate synthase
Afer_1991	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Afer_1992	COG1473	amidohydrolase
Afer_1995	COG0004	ammonium transporteR
Afer_2002	COG0277	FAD linked oxidase domain protein
Afer_2006	COG3979	chitinase
Afer_2012	COG3046	protein related to deoxyribodipyrimidine photolyase
Afer_2015	COG2963	transposase activity
Afer_2016	COG1487	ribonuclease activity
Afer_2018	COG0590	tRNA wobble adenosine to inosine editing
Afer_2021	COG3384	dioxygenase
Afer_2024	COG1414	Transcriptional regulator
Afer_2025	COG0402	S-adenosylhomocysteine deaminase activity
Afer_2031	COG1192	Involved in chromosome partitioning
Afer_2033	COG0357	Ribosomal RNA small subunit methyltransferase G
Afer_2034	COG1847	R3H domain protein
Afer_2036	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Afer_2037	COG0594	ribonuclease P activity
Afer_2038	COG0230	Belongs to the bacterial ribosomal protein bL34 family