locus-tag class description PACID_00010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) PACID_00020 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) PACID_00030 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) PACID_00050 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) PACID_00070 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) PACID_00080 ENOG4105K7N UPF0232 protein PACID_00100 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) PACID_00110 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) PACID_00120 ENOG4108ZED Transmembrane domain of unknown function (DUF3566) PACID_00130 ENOG4107TYG Oxidoreductase domain-containing protein PACID_00140 ENOG4105ETE Transcriptional regulator (LacI family PACID_00150 ENOG4105C2J ABC transporter PACID_00160 ENOG4105CNN ABC, transporter PACID_00170 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator PACID_00180 ENOG4108RVA ribokinase PACID_00190 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) PACID_00240 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr PACID_00270 ENOG4106F59 XRE family Transcriptional regulator PACID_00350 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) PACID_00380 ENOG4105C6K Malic enzyme PACID_00390 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) PACID_00400 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) PACID_00460 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase PACID_00470 ENOG4105F1A Pyruvate formate-lyase PACID_00590 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) PACID_00610 ENOG4105C7R Atpase associated with various cellular activities aaa_3 PACID_00740 ENOG4105D5G Transposase PACID_00780 ENOG4105XUP Phage derived protein Gp49-like (DUF891) PACID_00810 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) PACID_00820 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) PACID_00860 ENOG4107VMI polysaccharide deacetylase PACID_00880 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase PACID_00900 ENOG4105CPQ Dehydrogenase PACID_00910 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) PACID_00920 ENOG4105DT3 PTS system, galactitol-specific IIc component PACID_00960 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) PACID_00970 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase PACID_01020 ENOG4105DVE abc transporter atp-binding protein PACID_01040 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) PACID_01050 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) PACID_01070 ENOG4105E5Q amino acid AbC transporter PACID_01080 ENOG4105CDA abc transporter atp-binding protein PACID_01090 ENOG4105CIH Imidazole acetol-phosphate transaminase PACID_01120 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component PACID_01130 ENOG4105I1K ABC transporter PACID_01140 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) PACID_01180 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate PACID_01320 ENOG4105C26 Dehydrogenase PACID_01340 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) PACID_01400 ENOG4105CKU formyltetrahydrofolate synthetase PACID_01450 ENOG4105C19 ABC transporter PACID_01460 ENOG4105WH1 Two component transcriptional regulator luxr family PACID_01480 ENOG4105YES addiction module antidote protein PACID_01490 ENOG4105VUH addiction module killer protein PACID_01500 ENOG4105E0Y RtcB Protein PACID_01520 ENOG4105BZ1 (ABC) transporter PACID_01550 ENOG4105EDW glycosyl transferase, family 39 PACID_01570 ENOG4105BZU Histidine kinase PACID_01580 ENOG4105EDW glycosyl transferase, family 39 PACID_01590 ENOG4105BZU Histidine kinase PACID_01610 ENOG4105GR3 Histidine kinase PACID_01620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family PACID_01640 ENOG4107R16 Multicopper oxidase PACID_01710 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) PACID_01740 ENOG410635A Membrane PACID_01800 ENOG4105CV8 reductase PACID_01870 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) PACID_01890 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) PACID_01920 ENOG4107QK4 glycoside hydrolase, family 3 domain protein PACID_01930 ENOG41067SE Tetr family transcriptional regulator PACID_01950 ENOG4105EYF MMPL domain protein PACID_01990 ENOG4108JQ1 Dehydrogenase PACID_02000 ENOG4105BZ4 penicillin-binding protein PACID_02020 ENOG4105C2C drug resistance transporter, Bcr CflA PACID_02040 ENOG4105C0R drug resistance transporter emrb qaca subfamily PACID_02050 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) PACID_02060 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) PACID_02070 ENOG4107RPQ ABC transporter PACID_02100 ENOG4105C6K Malic enzyme PACID_02140 ENOG41086YM Acylphosphatase PACID_02150 ENOG4105CMV Succinyl-CoA synthetase subunit beta PACID_02160 ENOG4105D8K carboxyl transferase PACID_02190 ENOG4105D9Q decarboxylase (Beta subunit) PACID_02220 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) PACID_02270 ENOG4105CTQ phosphohexokinase PACID_02350 ENOG4105K78 MarR family Transcriptional regulator PACID_02370 ENOG4105C59 p-type ATPase PACID_02390 ENOG4105DS0 Transcriptional regulator, Crp Fnr family PACID_02400 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction PACID_02480 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) PACID_02510 ENOG4105CHF Glutathione S-transferase PACID_02530 ENOG4108JQ6 ABC transporter PACID_02540 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PACID_02550 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component PACID_02580 ENOG4105F4R Transcriptional regulator mode PACID_02630 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) PACID_02640 ENOG4107TVJ ,Oxidoreductase FAD NAD(P)-binding PACID_02650 ENOG4108SQ9 flavin reductase domain protein, FMN-binding PACID_02710 ENOG4108IUE nitrate reductase beta subunit PACID_02750 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) PACID_02770 ENOG4108ZAF Molybdopterin PACID_02790 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) PACID_02800 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) PACID_02820 ENOG4105DWF phosphomethylpyrimidine kinase PACID_02830 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) PACID_02840 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis PACID_02870 ENOG41062B0 ABC transporter, permease PACID_02880 ENOG4107R9N ABC transporter PACID_02890 ENOG4105C2J ABC transporter PACID_02900 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator PACID_02910 ENOG4105ETE Transcriptional regulator (LacI family PACID_02920 ENOG41068JE domain protein PACID_02960 ENOG4105DZW Dipeptidase PACID_02980 ENOG4105C26 Dehydrogenase PACID_03000 ENOG4105ETE Transcriptional regulator (LacI family PACID_03010 ENOG4105D2H Uronic isomerase PACID_03020 ENOG4105DEI Mannitol dehydrogenase PACID_03030 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) PACID_03050 ENOG4105CV8 reductase PACID_03070 ENOG4105DTQ mandelate racemase muconate lactonizing PACID_03110 ENOG4105KT7 mgtC SapB transporter PACID_03130 ENOG4105ETE Transcriptional regulator (LacI family PACID_03140 ENOG4107T6V glycerophosphoryl diester phosphodiesterase PACID_03250 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) PACID_03270 ENOG4107QRT dEAD DEAH box helicase PACID_03310 ENOG4108KQ5 Integrase catalytic subunit PACID_03370 ENOG4106F1P AAA ATPase, central domain protein PACID_03380 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) PACID_03480 ENOG4107QNK )-transporter PACID_03490 ENOG4105C93 Xylose Isomerase PACID_03540 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) PACID_03550 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) PACID_03580 ENOG4105C4X radical SAM domain protein PACID_03590 ENOG4105CBG Sulfatase PACID_03660 ENOG4105EIP mannose-6-phosphate isomerase PACID_03670 ENOG4105EDK PfkB domain protein PACID_03680 ENOG4108FUF Transcriptional regulator, IclR family PACID_03690 ENOG4108UHU Aldolase PACID_03700 ENOG4105ETE Transcriptional regulator (LacI family PACID_03710 ENOG4107QZW Altronate oxidoreductase PACID_03720 ENOG4105CTX dehydratase PACID_03730 ENOG4105D2H Uronic isomerase PACID_03800 ENOG4105D2H Uronic isomerase PACID_03810 ENOG4107QZW Altronate oxidoreductase PACID_03860 ENOG4107QN2 dihydrolipoyl dehydrogenase PACID_03870 ENOG4105F9F transposase PACID_03910 ENOG4105CNT hydrolase family 2 PACID_03920 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate PACID_04060 ENOG4105CT4 transporter PACID_04140 ENOG4105EQN UPF0261 protein PACID_04150 ENOG41073TP transcriptional regulator PACID_04180 ENOG4105ETE Transcriptional regulator (LacI family PACID_04190 ENOG4105ETE Transcriptional regulator (LacI family PACID_04200 ENOG4105D1H recombination factor protein RarA PACID_04230 ENOG4105DKW ABC transporter PACID_04250 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) PACID_04270 ENOG4107T5V SNARE associated Golgi PACID_04280 ENOG4105CPQ Dehydrogenase PACID_04310 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) PACID_04370 ENOG4105C37 (CBS) domain PACID_04390 ENOG4108Z7F N-acetyltransferase PACID_04440 ENOG4105F95 Monooxygenase PACID_04570 ENOG4105BZ4 penicillin-binding protein PACID_04610 ENOG4105CKK Glycosyl transferase, family 2 PACID_04640 ENOG4107T8Q Glycosyl transferase (Group 1 PACID_04650 ENOG4107T8Q Glycosyl transferase (Group 1 PACID_04660 ENOG4107EF8 Glycosyl transferase (Group 1 PACID_04710 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) PACID_04770 ENOG4105DM4 PTS System PACID_04780 ENOG4105DE4 1-phosphofructokinase PACID_04790 ENOG4105E98 transcriptional regulator DeoR family PACID_04800 ENOG4105DRP amino acid AbC transporter PACID_04810 ENOG4108Q1T ABC transporter PACID_04820 ENOG4107UBR Extracellular solute-binding protein family 3 PACID_04830 ENOG4105CDA abc transporter atp-binding protein PACID_04850 ENOG4108IJ1 Dehydrogenase PACID_04880 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase PACID_04980 ENOG4105CQ7 ATP-dependent helicase PACID_05010 ENOG4108VX5 3-methyladenine DNA glycosylase PACID_05050 ENOG4108V8F Transcriptional regulator, MarR family PACID_05060 ENOG4108V06 Glutathione peroxidase PACID_05070 ENOG4105C3M thioredoxin reductase PACID_05080 ENOG4105K63 Thioredoxin PACID_05090 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) PACID_05100 ENOG4105CDU Replicative dna helicase PACID_05110 ENOG4105VPX protein, conserved in bacteria PACID_05140 ENOG4105K6T rare lipoprotein A PACID_05160 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) PACID_05170 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) PACID_05200 ENOG41073TP transcriptional regulator PACID_05220 ENOG4105DAA L-lactate PACID_05230 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) PACID_05250 ENOG41080R8 Conserved Protein PACID_05260 ENOG4105BZ1 (ABC) transporter PACID_05270 ENOG4108JJ9 ABC, transporter PACID_05280 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii PACID_05290 ENOG4105C4M (Ubiquinol oxidase) subunit I PACID_05310 ENOG4105WH1 Two component transcriptional regulator luxr family PACID_05370 ENOG4108JB8 alcohol dehydrogenase PACID_05400 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component PACID_05430 ENOG4105ETE Transcriptional regulator (LacI family PACID_05460 ENOG4105KBX Transcriptional regulator, TetR family PACID_05470 ENOG4107VXZ Hydrolase PACID_05500 ENOG4105C5B carbamate kinase PACID_05520 ENOG4107REC cytoplasmic protein PACID_05530 ENOG4107R1Q Membrane protein FdrA PACID_05540 ENOG4107YCY Transcriptional regulator PACID_05580 ENOG4105C5R Aminotransferase PACID_05600 ENOG4105CK2 sodium dicarboxylate symporter PACID_05610 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease PACID_05630 ENOG4105K8R UPF0145 protein PACID_05640 ENOG4105CRK lysyL-tRNA synthetase PACID_05650 ENOG4105ZJT Cell division protein CrgA PACID_05690 ENOG4105CJN penicillin-binding protein PACID_05720 ENOG4105HZM Fha domain containing protein PACID_05730 ENOG4105TV9 FHA Domain-Containing protein PACID_05760 ENOG4105C1B dTDP-glucose 4-6-dehydratase PACID_05770 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) PACID_05800 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein PACID_05810 ENOG4105D3Q Sugar transferase PACID_05830 ENOG4108KGH TRANSCRIPTIONal PACID_05890 ENOG4105CSH Transporter PACID_05930 ENOG4105C85 amino acid PACID_05950 ENOG4108X07 Tetr family transcriptional regulator PACID_05960 ENOG4105CIG ABC transporter PACID_06040 ENOG41087ID Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) PACID_06050 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) PACID_06100 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) PACID_06130 ENOG410667J hydrolase PACID_06140 ENOG4108HCJ Hydrolase PACID_06150 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) PACID_06200 ENOG4105CFH Aspartokinase PACID_06250 ENOG4105D94 Major Facilitator Superfamily PACID_06260 ENOG4107RSM transcriptional regulator PACID_06300 ENOG41085J0 Protein CrcB homolog PACID_06310 ENOG41083TI Protein CrcB homolog PACID_06340 ENOG4108FN7 Aldo keto reductase PACID_06380 ENOG4108V1U phospholipid-binding protein PACID_06400 ENOG4105CQR helicase PACID_06420 ENOG4107QP8 phosphohexose isomerase PACID_06450 ENOG4105IE8 Alpha-ketoglutarate permease PACID_06460 ENOG4105CV8 reductase PACID_06470 ENOG4105C75 arginyL-tRNA synthetase PACID_06520 ENOG4105C54 Major Facilitator superfamily PACID_06550 ENOG4105C26 Dehydrogenase PACID_06560 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) PACID_06570 ENOG4105DET Rhamnulokinase PACID_06580 ENOG4105C9F isomerase PACID_06610 ENOG4105ETE Transcriptional regulator (LacI family PACID_06690 ENOG4105ETE Transcriptional regulator (LacI family PACID_06710 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component PACID_06720 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PACID_06740 ENOG4108IJ0 Aspartate ammonia-lyase PACID_06800 ENOG4105C57 major facilitator superfamily PACID_06810 ENOG4108IG5 Transcriptional regulator PACID_06840 ENOG4108JQ7 (ABC) transporter PACID_06870 ENOG4105CJ1 ABC, transporter PACID_06880 ENOG4105EJ2 Transcriptional regulator PACID_06910 ENOG4105XN3 extracellular solute-binding protein family 1 PACID_06930 ENOG4105I1K ABC transporter PACID_06960 ENOG4105DSB aldose 1-epimerase PACID_06970 ENOG4105EAC phosphoserine phosphatase PACID_06980 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) PACID_06990 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) PACID_07000 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) PACID_07040 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) PACID_07050 ENOG4105BZU Histidine kinase PACID_07060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family PACID_07090 ENOG4105CFG Acts as a chaperone (By similarity) PACID_07100 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ PACID_07110 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) PACID_07120 ENOG4105KNI merR family transcriptional Regulator PACID_07130 ENOG4105CPQ Dehydrogenase PACID_07140 ENOG4107FQX Alpha-acetolactate decarboxylase PACID_07150 ENOG4107WGA YidE YbjL PACID_07160 ENOG4105C85 amino acid PACID_07190 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) PACID_07230 ENOG4105WH1 Two component transcriptional regulator luxr family PACID_07240 ENOG4105BZU Histidine kinase PACID_07280 ENOG4105WYW fructose-bisphosphate aldolase PACID_07290 ENOG4105ETE Transcriptional regulator (LacI family PACID_07310 ENOG4107RBJ symporter PACID_07340 ENOG4105DRS transport system, permease PACID_07360 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit PACID_07370 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component PACID_07380 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component PACID_07400 ENOG4105EDK PfkB domain protein PACID_07410 ENOG4105E98 transcriptional regulator DeoR family PACID_07420 ENOG4105F8D glycoside hydrolase family 4 PACID_07450 ENOG4105ECB domain protein PACID_07480 ENOG4105ECR NmrA family PACID_07530 ENOG4105DZR Type I site-specific deoxyribonuclease PACID_07550 ENOG4105CVR type I restriction-modification system PACID_07610 ENOG4105K5B UPF0225 protein PACID_07620 ENOG4108IJ7 Glycine betaine PACID_07630 ENOG4107SQ8 Glycine betaine PACID_07660 ENOG4107U9B transcriptional regulator PACID_07670 ENOG4105CJ1 ABC, transporter PACID_07700 ENOG4105E90 ABC transporter PACID_07710 ENOG4108IJ8 ABC transporter PACID_07720 ENOG4105E90 ABC transporter PACID_07740 ENOG4105C26 Dehydrogenase PACID_07750 ENOG4105CHM Aminotransferase PACID_07790 ENOG4108V0P LemA family PACID_07800 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) PACID_07840 ENOG4107SBE Glycosyl transferase (Group 1 PACID_07860 ENOG4107Y2G Glycosyl transferase (Group 1 PACID_07880 ENOG4105PSV Polysaccharide Biosynthesis Protein PACID_07890 ENOG4107YJ4 chain length determinant protein PACID_07930 ENOG4105DQR SNARE associated Golgi PACID_07960 ENOG4107RCW fructose-bisphosphate aldolase PACID_07970 ENOG4107QSA Oxaloacetate decarboxylase PACID_07980 ENOG4107QX3 carboxylase PACID_07990 ENOG4107QX3 carboxylase PACID_08000 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein PACID_08020 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) PACID_08030 ENOG410849S phosphocarrier protein (HPr) PACID_08040 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) PACID_08050 ENOG4108UTW Plays a role in the regulation of phosphate uptake PACID_08060 ENOG4105BZU Histidine kinase PACID_08100 ENOG4108VJ1 Transcriptional regulator (CarD family PACID_08110 ENOG41082GB PTS system galactitol-specific transporter subunit IIA PACID_08130 ENOG4105DT3 PTS system, galactitol-specific IIc component PACID_08150 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase PACID_08190 ENOG4105DZY Pts system, glucitol sorbitol-specific PACID_08230 ENOG4105CPQ Dehydrogenase PACID_08240 ENOG4108JQ1 Dehydrogenase PACID_08260 ENOG4105D2N Aldolase PACID_08290 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) PACID_08300 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) PACID_08340 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) PACID_08380 ENOG4105EQ0 Major Facilitator superfamily PACID_08410 ENOG4105C8N cysteinyl-tRNA synthetase PACID_08440 ENOG4105C28 cystathionine PACID_08580 ENOG4107URF beta-phospho-glucomutase PACID_08600 ENOG4105EJQ L-serine dehydratase PACID_08610 ENOG4105DKQ ROK family PACID_08630 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component PACID_08640 ENOG4105DRS transport system, permease PACID_08650 ENOG4105CPQ Dehydrogenase PACID_08660 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) PACID_08680 ENOG4108UVJ appr-1-p processing domain protein PACID_08690 ENOG4108M15 ABC transporter PACID_08710 ENOG4108ZGX Histidine kinase PACID_08720 ENOG4108S01 response regulator PACID_08740 ENOG4105CVJ phosphoglycerate mutase PACID_08770 ENOG4105ENE Histidine kinase PACID_08780 ENOG4105WH1 Two component transcriptional regulator luxr family PACID_08790 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) PACID_08800 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) PACID_08820 ENOG4105CIA precorrin-4 C(11)-methyltransferase PACID_08830 ENOG4105E4R Precorrin-3B C17-methyltransferase PACID_08840 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) PACID_08870 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) PACID_08890 ENOG4108V4M Cobalt abc transporter PACID_08900 ENOG4108JJB ABC transporter PACID_08910 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase PACID_08920 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase PACID_08930 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) PACID_08940 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) PACID_08960 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) PACID_08970 ENOG4108YZT Adenosylcobinamide kinase PACID_09020 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) PACID_09040 ENOG4105EIP mannose-6-phosphate isomerase PACID_09060 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) PACID_09120 ENOG4106N3A copper homeostasis protein cutc PACID_09160 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) PACID_09170 ENOG4105VEQ Cold shock protein PACID_09200 ENOG4105C7N Xanthine uracil vitamin C permease PACID_09250 ENOG4105CE4 GlcNAc 6-P deacetylase PACID_09260 ENOG4107R5H iron (metal) dependent repressor, dtxr family PACID_09270 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) PACID_09290 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) PACID_09300 ENOG4105D7K pfkb domain protein PACID_09320 ENOG4105DH8 myo-inositol catabolism PACID_09330 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) PACID_09350 ENOG41060NJ transcriptional regulator PACID_09360 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) PACID_09370 ENOG4105C54 Major Facilitator superfamily PACID_09420 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) PACID_09450 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase PACID_09570 ENOG4105C0D helicase PACID_09620 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein PACID_09630 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) PACID_09700 ENOG4108Z0Z intracellular protease Pfpi family PACID_09810 ENOG4105E7W lamb ycsf family protein PACID_09820 ENOG4105P4J Allophanate hydrolase, subunit 1 PACID_09840 ENOG4105C2W permease PACID_09870 ENOG4105F8V Hydrolase, tatD family PACID_09880 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) PACID_09890 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) PACID_09900 ENOG41082F9 transcriptional regulator PACID_09910 ENOG4105U5Y Transcriptional regulator PACID_09930 ENOG4107U1N Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) PACID_09940 ENOG4105C5T Phosphoribosyl pyrophosphate synthase PACID_09950 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) PACID_09960 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) PACID_10000 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) PACID_10060 ENOG4105EZR dyp-type peroxidase family protein PACID_10070 ENOG4105C0H protease PACID_10170 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) PACID_10180 ENOG41084BS 50S ribosomal protein L35 PACID_10190 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) PACID_10200 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase PACID_10220 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) PACID_10230 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) PACID_10240 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) PACID_10270 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) PACID_10350 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) PACID_10360 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) PACID_10390 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) PACID_10420 ENOG4105C7Z Conserved Protein PACID_10430 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) PACID_10450 ENOG4108IAB Phoh family PACID_10470 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) PACID_10480 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) PACID_10500 ENOG4105DFM M18 family aminopeptidase PACID_10510 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) PACID_10540 ENOG4105C3G gtp-binding protein PACID_10550 ENOG4105CVR type I restriction-modification system PACID_10560 ENOG4107XZC Restriction modification system DNA (Specificity PACID_10570 ENOG4105DZR Type I site-specific deoxyribonuclease PACID_10690 ENOG41080ET plasmid maintenance system killer protein PACID_10700 ENOG4105VDM plasmid maintenance system antidote protein, xre family PACID_10740 ENOG4105DIM ABC transporter PACID_10750 ENOG4105CIG ABC transporter PACID_10760 ENOG41080ET plasmid maintenance system killer protein PACID_10770 ENOG4105VDM plasmid maintenance system antidote protein, xre family PACID_10910 ENOG41065RQ ADP-ribosylation crystallin J1 PACID_10940 ENOG4105BZ1 (ABC) transporter PACID_10950 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) PACID_10990 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) PACID_11050 ENOG4105CSH Transporter PACID_11060 ENOG4105CSH Transporter PACID_11110 ENOG4105RH4 Glycine cleavage system transcriptional repressor PACID_11150 ENOG4108IQI permease PACID_11200 ENOG4105CMN Methylmalonyl-coA mutase PACID_11210 ENOG4105D5P Methylmalonyl-coA mutase PACID_11230 ENOG410848D S4 domain protein YaaA PACID_11270 ENOG4105E5Q amino acid AbC transporter PACID_11330 ENOG4105CC5 ABC transporter PACID_11340 ENOG4105DIK (ABC) transporter PACID_11380 ENOG4105C26 Dehydrogenase PACID_11390 ENOG4105CPQ Dehydrogenase PACID_11400 ENOG4105CMT Dihydroxyacetone kinase PACID_11410 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) PACID_11420 ENOG4105E98 transcriptional regulator DeoR family PACID_11430 ENOG4107YVI ribose 5-phosphate isomerase PACID_11450 ENOG4105D4U had-superfamily hydrolase, subfamily iia PACID_11470 ENOG4105D49 3-dehydroquinate synthase PACID_11480 ENOG4105EF1 ribulokinase PACID_11550 ENOG4107Y80 Major Facilitator superfamily PACID_11560 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) PACID_11570 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) PACID_11580 ENOG4107S1E Beta-lactamase PACID_11590 ENOG4107RBI VanW family PACID_11600 ENOG4108Z4U Ferredoxin PACID_11640 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) PACID_11660 ENOG4108URH decarboxylase PACID_11690 ENOG4107QPH glycogen) synthase PACID_11700 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) PACID_11740 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) PACID_11750 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) PACID_11820 ENOG4107T6F Xaa-Pro aminopeptidase PACID_11860 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) PACID_11870 ENOG4105CUB amino acid PACID_11900 ENOG4105D7N magnesium and cobalt transport protein CorA PACID_11950 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) PACID_11970 ENOG4105EGD dinuclear metal center protein, YbgI family PACID_11990 ENOG4105VDM plasmid maintenance system antidote protein, xre family PACID_12010 ENOG4105C5F glutamine synthetase PACID_12050 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN PACID_12060 ENOG4105CJW magnesium transporter PACID_12070 ENOG4105C5H ABC transporter PACID_12090 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) PACID_12120 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) PACID_12210 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) PACID_12230 ENOG4105MCD Part of cytochrome c oxidase, its function is PACID_12260 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) PACID_12270 ENOG4107EUI c reductase, iron-sulfur PACID_12280 ENOG4107UDY cytochrome C PACID_12290 ENOG4105CCU oxidase (Subunit III) PACID_12310 ENOG4107S1N anthranilate phosphoribosyltransferase PACID_12410 ENOG4105DKQ ROK family PACID_12450 ENOG4105WH1 Two component transcriptional regulator luxr family PACID_12460 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase PACID_12510 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) PACID_12530 ENOG4105SYT Methylenetetrahydrofolate reductase PACID_12540 ENOG4105C4R Atp-dependent dna helicase PACID_12590 ENOG4105D7T ABC transporter PACID_12600 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) PACID_12620 ENOG4108J5G 6-phosphogluconate dehydrogenase PACID_12630 ENOG4105C6Z Gluconate PACID_12640 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family PACID_12680 ENOG4105CJ1 ABC, transporter PACID_12690 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor PACID_12700 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) PACID_12710 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) PACID_12730 ENOG4105F8C transglutaminase domain-containing protein PACID_12750 ENOG4105C7R Atpase associated with various cellular activities aaa_3 PACID_12760 ENOG4108V6E Cell division protein mraZ PACID_12770 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) PACID_12790 ENOG4105CJN penicillin-binding protein PACID_12820 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) PACID_12830 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) PACID_12840 ENOG4105CNI cell division protein FtsW PACID_12850 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) PACID_12860 ENOG4105DFU Cell wall formation (By similarity) PACID_12870 ENOG4105ME9 cell division protein FtsQ PACID_12880 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) PACID_12890 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase PACID_12900 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) PACID_12930 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters PACID_12960 ENOG4105CA9 Pyruvate kinase PACID_12990 ENOG4105KA0 thioesterase Superfamily protein PACID_13040 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) PACID_13050 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) PACID_13080 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) PACID_13110 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) PACID_13150 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) PACID_13160 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) PACID_13170 ENOG4105CHW UPF0052 protein PACID_13180 ENOG4105CIE May be required for sporulation (By similarity) PACID_13190 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase PACID_13200 ENOG4105BZA Phosphoglycerate kinase PACID_13210 ENOG4105CP7 Triose-phosphate isomerase PACID_13240 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase PACID_13260 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) PACID_13280 ENOG4105D17 glycoside hydrolase, family 3 domain protein PACID_13300 ENOG4105C03 ribonuclease PACID_13310 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) PACID_13320 ENOG4105K46 50S ribosomal protein l27 PACID_13340 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control PACID_13350 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) PACID_13360 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) PACID_13380 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) PACID_13480 ENOG4105EW9 transcriptional regulator AsnC family PACID_13720 ENOG4107Y2X deaminase PACID_13740 ENOG4107ZXU DSBA oxidoreductase PACID_13770 ENOG4105C8T Leucyl-tRNA synthetase PACID_13790 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 PACID_13800 ENOG4105F8X type iii restriction PACID_13820 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) PACID_13830 ENOG4107QW3 Sucrose phosphorylase PACID_13840 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) PACID_13880 ENOG4107TCW O-succinylbenzoate synthase PACID_13890 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) PACID_13900 ENOG4105E4F Isochorismate synthase PACID_13920 ENOG4107SIQ Naphthoate synthase PACID_13940 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) PACID_13950 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) PACID_13970 ENOG4105CIG ABC transporter PACID_13990 ENOG4105CSH Transporter PACID_14010 ENOG4105DRS transport system, permease PACID_14060 ENOG4105ECY inositol monophosphatase PACID_14090 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) PACID_14100 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) PACID_14120 ENOG4105CPQ Dehydrogenase PACID_14130 ENOG4105CTS PTS system mannitol-specific PACID_14150 ENOG4105C9U ATP-dependent DNA helicase RecQ PACID_14160 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) PACID_14170 ENOG4107AQZ Membrane PACID_14180 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) PACID_14200 ENOG4105WH1 Two component transcriptional regulator luxr family PACID_14210 ENOG4108IUX (ABC) transporter PACID_14290 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) PACID_14330 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) PACID_14350 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) PACID_14380 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) PACID_14390 ENOG4105CT1 (ABC) transporter PACID_14400 ENOG4105E5Q amino acid AbC transporter PACID_14410 ENOG4105DRP amino acid AbC transporter PACID_14430 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) PACID_14450 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin PACID_14460 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) PACID_14490 ENOG4105CPC Aldo Keto reductase PACID_14540 ENOG4108C33 Resolvase PACID_14780 ENOG41068JE domain protein PACID_14890 ENOG4105C7R Atpase associated with various cellular activities aaa_3 PACID_14910 ENOG4107QVM von Willebrand factor, type A PACID_14930 ENOG4105DFA alanine racemase domain protein PACID_14960 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) PACID_14990 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) PACID_15020 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) PACID_15040 ENOG4105CPC Aldo Keto reductase PACID_15060 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) PACID_15070 ENOG4105CD3 dihydroorotase PACID_15080 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain PACID_15090 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain PACID_15100 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) PACID_15110 ENOG4107TYT Catalyzes the conversion of dihydroorotate to orotate (By similarity) PACID_15120 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) PACID_15130 ENOG4107T52 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) PACID_15190 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) PACID_15210 ENOG4105CEV competence damage-inducible protein PACID_15230 ENOG4105E98 transcriptional regulator DeoR family PACID_15250 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) PACID_15270 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) PACID_15280 ENOG4107WI4 Aldose-1-epimerase PACID_15290 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) PACID_15940 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) PACID_15950 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) PACID_15960 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) PACID_16000 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) PACID_16010 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) PACID_16020 ENOG4105DHP deoxycytidine triphosphate deaminase PACID_16060 ENOG4105CQ7 ATP-dependent helicase PACID_16080 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) PACID_16110 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) PACID_16150 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) PACID_16180 ENOG4105EPD Oligopeptide transporter, Opt family PACID_16250 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) PACID_16290 ENOG4107VEG TrkA-N domain protein PACID_16300 ENOG4105C0X amino acid PACID_16310 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) PACID_16330 ENOG4107QM5 aconitate hydratase PACID_16340 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) PACID_16370 ENOG4105E0X reductase PACID_16380 ENOG4105CSR polyphosphate kinase 2 PACID_16440 ENOG4108ZJ4 polysaccharide deacetylase PACID_16510 ENOG4105DQ4 alcohol dehydrogenase PACID_16520 ENOG4105C22 threonyL-tRNA synthetase PACID_16550 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase PACID_16560 ENOG4105E2K Glycosyl transferase (Group 1 PACID_16610 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) PACID_16620 ENOG4108UW8 fha domain-containing protein PACID_16660 ENOG4107H3J ribonuclease PACID_16670 ENOG4107RJF diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90) PACID_16690 ENOG4107RTD sua5 ycio yrdc ywlc family protein PACID_16700 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) PACID_16710 ENOG4107TE5 Lipid kinase PACID_16730 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein PACID_16760 ENOG4105CFG Acts as a chaperone (By similarity) PACID_16800 ENOG4107QZ7 Cellulose synthase catalytic subunit PACID_16830 ENOG4105CUB amino acid PACID_16880 ENOG4105D22 carbon starvation protein PACID_16910 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) PACID_16920 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) PACID_16940 ENOG4105Q70 PACID_16950 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) PACID_16960 ENOG4107R05 Transfers the fatty acyl group on membrane lipoproteins (By similarity) PACID_16980 ENOG4105DWV Homoserine O-trans-acetylase PACID_16990 ENOG4105DWV Homoserine O-trans-acetylase PACID_17000 ENOG4105CYC Transferase PACID_17190 ENOG4105W1N transcriptional regulator PACID_17230 ENOG4105DNP FAD linked oxidase domain protein PACID_17250 ENOG4105C8Y Acetylornithine aminotransferase PACID_17290 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PACID_17310 ENOG4107S1Q Phosphatase PACID_17380 ENOG4105DZR Type I site-specific deoxyribonuclease PACID_17450 ENOG4108Z9K Osmotically inducible protein PACID_17470 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) PACID_17480 ENOG4105CAT Cytidine monophosphate kinase PACID_17500 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) PACID_17510 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) PACID_17540 ENOG4105C3R Methionine synthase PACID_17560 ENOG4105DJV ribulose-phosphate 3-epimerase PACID_17580 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) PACID_17640 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) PACID_17650 ENOG4107QRT dEAD DEAH box helicase PACID_17660 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP PACID_17680 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) PACID_17690 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) PACID_17710 ENOG410803B Involved in the transcription termination process (By similarity) PACID_17720 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) PACID_17740 ENOG4105D49 3-dehydroquinate synthase PACID_17750 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) PACID_17760 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase PACID_17770 ENOG4105E2X shikimate dehydrogenase PACID_17790 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) PACID_17800 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) PACID_17870 ENOG4105C9M aspartyl-trna synthetase PACID_17900 ENOG4107MVR Transcriptional regulator PACID_17910 ENOG4105CIZ coA-substrate-specific enzyme activase PACID_17920 ENOG4105CUT histidyl-tRNA synthetase PACID_17930 ENOG4105C5X domain protein PACID_17940 ENOG4105C99 atpase involved in dna repair PACID_17950 ENOG4105D98 threonine synthase PACID_17960 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) PACID_17980 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) PACID_17990 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) PACID_18020 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) PACID_18030 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) PACID_18040 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) PACID_18050 ENOG4105CDY transcriptional regulatory protein PACID_18060 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase PACID_18070 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) PACID_18080 ENOG4105ECC imidazole-glycerol-phosphate dehydratase PACID_18090 ENOG4105CIH Imidazole acetol-phosphate transaminase PACID_18100 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) PACID_18170 ENOG4105DRS transport system, permease PACID_18190 ENOG4105ETE Transcriptional regulator (LacI family PACID_18210 ENOG4105CBC glutamate synthase PACID_18220 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) PACID_18230 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) PACID_18250 ENOG4105DK0 Indole-3-glycerol phosphate synthase PACID_18280 ENOG4105CRQ synthase (Component I) PACID_18290 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase PACID_18320 ENOG41090R7 Ferric uptake PACID_18340 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) PACID_18360 ENOG4108IYU L-aspartate oxidase PACID_18370 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) PACID_18390 ENOG4105CVK Glutamate decarboxylase PACID_18500 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein PACID_18510 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) PACID_18520 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) PACID_18560 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase PACID_18600 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PACID_18620 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) PACID_18640 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) PACID_18660 ENOG4108QVN serine threonine protein kinase PACID_18680 ENOG4105C0R drug resistance transporter emrb qaca subfamily PACID_18710 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) PACID_18740 ENOG4107QJE Chromosome Partitioning Protein PACID_18880 ENOG4108C33 Resolvase PACID_18980 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) PACID_18990 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) PACID_19000 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) PACID_19050 ENOG4108IY8 ABC, transporter PACID_19080 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) PACID_19140 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) PACID_19150 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) PACID_19160 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) PACID_19200 ENOG4107UVD Beta-phosphoglucomutase family hydrolase PACID_19220 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 PACID_19280 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) PACID_19340 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) PACID_19350 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) PACID_19360 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) PACID_19370 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) PACID_19380 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) PACID_19390 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) PACID_19400 ENOG4106DE0 ATP synthase PACID_19410 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) PACID_19440 ENOG4105D7W serine acetyltransferase PACID_19460 ENOG4105CAQ asparagine synthetase PACID_19490 ENOG4105CEY Amp-dependent synthetase and ligase PACID_19630 ENOG4105ESV Glycosyl transferase, family 4 PACID_19650 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) PACID_19660 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) PACID_19670 ENOG4105VFB Binds the 23S rRNA (By similarity) PACID_19690 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) PACID_19700 ENOG4105D6E homoserine dehydrogenase PACID_19720 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) PACID_19740 ENOG4108URH decarboxylase PACID_19760 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 PACID_19830 ENOG4105EMN RNA polymerase sigma factor PACID_19850 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase PACID_19860 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) PACID_19880 ENOG4107TK4 histidinol-phosphate phosphatase PACID_19890 ENOG4108JQ1 Dehydrogenase PACID_19910 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PACID_19930 ENOG4105DEF Extracellular solute-binding protein, family 5 PACID_19970 ENOG4107QK4 glycoside hydrolase, family 3 domain protein PACID_19980 ENOG4105DJZ UPF0182 protein PACID_20000 ENOG41063PX domain protein PACID_20050 ENOG4105DSY exodeoxyribonuclease V, gamma PACID_20060 ENOG4107QKA exodeoxyribonuclease V beta PACID_20070 ENOG4105C7H Helicase, RecD TraA family PACID_20090 ENOG4105C4R Atp-dependent dna helicase PACID_20100 ENOG4105VEQ Cold shock protein PACID_20150 ENOG4105C31 Tryptophanyl-tRNA synthetase PACID_20170 ENOG4105DB7 PHP domain protein PACID_20210 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving PACID_20230 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea PACID_20260 ENOG4105BZU Histidine kinase PACID_20270 ENOG4105CK6 Two component transcriptional regulator (Winged helix family PACID_20280 ENOG4108UJU UPF0301 protein PACID_20300 ENOG4105CH7 arginosuccinase PACID_20310 ENOG4105DBV ornithine carbamoyltransferase PACID_20320 ENOG4105C8Y Acetylornithine aminotransferase PACID_20330 ENOG4105CAS nag kinase PACID_20340 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) PACID_20360 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) PACID_20370 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) PACID_20380 ENOG4105CAK Cell division ATP-binding protein ftsE PACID_20390 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) PACID_20420 ENOG4105KAF membrAne PACID_20440 ENOG4107QZI cell division protein FtsK PACID_20480 ENOG4105CPF Cell wall formation (By similarity) PACID_20500 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) PACID_20510 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) PACID_20520 ENOG41069M3 Transcriptional regulator PACID_20560 ENOG4105ERH Fumarylacetoacetate hydrolase PACID_20580 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) PACID_20590 ENOG4105CM2 brancheD-chain amino acid aminotransferase PACID_20600 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) PACID_20640 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase PACID_20650 ENOG4108ZP8 Acetolactate synthase small subunit PACID_20680 ENOG4105K59 histidine triad (HIT) protein PACID_20690 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) PACID_20710 ENOG4107TE5 Lipid kinase PACID_20730 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) PACID_20770 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) PACID_20840 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) PACID_20850 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) PACID_20860 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) PACID_20890 ENOG4108JJB ABC transporter PACID_20900 ENOG4105VKD bioY protein PACID_20910 ENOG4105DSU hydrolase PACID_20980 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) PACID_20990 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase PACID_21020 ENOG4105CPC Aldo Keto reductase PACID_21040 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) PACID_21090 ENOG4105ETE Transcriptional regulator (LacI family PACID_21100 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) PACID_21130 ENOG4107QNK )-transporter PACID_21150 ENOG4105BZ7 extracellular solute-binding protein family 1 PACID_21180 ENOG4105ETE Transcriptional regulator (LacI family PACID_21190 ENOG4105DRS transport system, permease PACID_21250 ENOG4105C0P Mg chelatase subunit ChlI PACID_21260 ENOG41080R2 UPF0102 protein PACID_21280 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) PACID_21290 ENOG4107QYR Signal peptidase i PACID_21300 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) PACID_21310 ENOG4105E33 succinate dehydrogenase PACID_21340 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) PACID_21350 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) PACID_21360 ENOG41082KU UPF0109 protein PACID_21370 ENOG4105K5M 30s ribosomal protein S16 PACID_21440 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 PACID_21530 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) PACID_21540 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) PACID_21550 ENOG41084BZ 50S ribosomal protein L32 PACID_21570 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) PACID_21580 ENOG4106H78 methyltransferase PACID_21620 ENOG4105VB9 50S ribosomal protein l28 PACID_21630 ENOG4105CN5 Metallo-Beta-Lactamase PACID_21650 ENOG4105C7K acetolactate synthase PACID_21670 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) PACID_21680 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) PACID_21690 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) PACID_21730 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) PACID_21760 ENOG410787A Pts system, glucitol sorbitol-specific PACID_21770 ENOG4105DZY Pts system, glucitol sorbitol-specific PACID_21780 ENOG4105VI0 Pts system, glucitol sorbitol-specific PACID_21800 ENOG4108MDK Dehydrogenase PACID_21810 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) PACID_21820 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) PACID_21830 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) PACID_21860 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) PACID_21900 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) PACID_21980 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) PACID_21990 ENOG4105DZP Membrane-associated zinc metalloprotease PACID_22010 ENOG4105D82 Glutamate dehydrogenase PACID_22020 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs PACID_22030 ENOG4105KNE Phosphatidate cytidylyltransferase PACID_22040 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) PACID_22050 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) PACID_22060 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) PACID_22070 ENOG4105CE9 30S ribosomal protein S2 PACID_22100 ENOG4105KKX ATPase associated with various cellular activities aaa_5 PACID_22110 ENOG4105RD5 PACID_22120 ENOG4105DEG Vwa containing coxe family protein PACID_22150 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) PACID_22170 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) PACID_22220 ENOG4105DHU Bile acid PACID_22250 ENOG4105DKW ABC transporter PACID_22270 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) PACID_22280 ENOG4108IJ0 Aspartate ammonia-lyase PACID_22310 ENOG4105CHR reductase PACID_22340 ENOG4107EXU Short-chain dehydrogenase reductase Sdr PACID_22370 ENOG4105C5H ABC transporter PACID_22460 ENOG4108UNV SUF system FeS assembly protein, NifU family PACID_22470 ENOG4105C9B Cysteine desulfurase PACID_22480 ENOG4105C3K feS assembly ATPase SufC PACID_22510 ENOG4105DIW FeS assembly protein SUFB PACID_22560 ENOG4105D56 permease protein PACID_22570 ENOG4105EG2 ABC transporter, permease PACID_22600 ENOG4105ETE Transcriptional regulator (LacI family PACID_22620 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for PACID_22650 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) PACID_22660 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) PACID_22690 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) PACID_22710 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) PACID_22740 ENOG4107RE3 peptidase, S41 PACID_22760 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) PACID_22770 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) PACID_22780 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) PACID_22790 ENOG4105DSF transport protein PACID_22800 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation PACID_23030 ENOG4105CRK lysyL-tRNA synthetase PACID_23070 ENOG4108YZG isomerase PACID_23100 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) PACID_23110 ENOG4105MC2 DSBA oxidoreductase PACID_23140 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) PACID_23160 ENOG4105DXB Major Facilitator superfamily PACID_23190 ENOG4108IQE Amp-dependent synthetase and ligase PACID_23220 ENOG4105CQB FAD linked oxidase domain protein PACID_23270 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) PACID_23290 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) PACID_23310 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) PACID_23370 ENOG4105C0D helicase PACID_23460 ENOG4108UIN ybak prolyl-trna synthetase associated region PACID_23470 ENOG4105JAB phenazine biosynthesis protein, phzf family PACID_23480 ENOG41089UC methyltransferase, type 11 PACID_23510 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) PACID_23520 ENOG4105WH1 Two component transcriptional regulator luxr family PACID_23530 ENOG4108XG2 Histidine kinase PACID_23550 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) PACID_23600 ENOG4105CJ1 ABC, transporter PACID_23640 ENOG4107QV8 Conserved hypothetical protein 698 PACID_23650 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) PACID_23660 ENOG4105CUB amino acid PACID_23680 ENOG4105C0B DNA polymerase III (alpha subunit) PACID_23720 ENOG4105DFU Cell wall formation (By similarity) PACID_23750 ENOG41089BK Glutamine amido-transferase PACID_23760 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) PACID_23810 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) PACID_23830 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) PACID_23840 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) PACID_23850 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) PACID_23860 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) PACID_23880 ENOG4105CE1 Ferrous iron transport protein b PACID_23910 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) PACID_23980 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) PACID_24060 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) PACID_24090 ENOG4105CJT Mannose-1-phosphate guanylyltransferase PACID_24120 ENOG4108KGH TRANSCRIPTIONal PACID_24160 ENOG4105EC3 peptidase S51, dipeptidase E PACID_24180 ENOG4105D8K carboxyl transferase PACID_24200 ENOG4107WR6 Maf-like protein PACID_24220 ENOG4105CEU Arginine dihydrolase PACID_24250 ENOG4105DWF phosphomethylpyrimidine kinase PACID_24270 ENOG4108JIK carboxylase PACID_24310 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain PACID_24360 ENOG4105C8Y Acetylornithine aminotransferase PACID_24370 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) PACID_24380 ENOG41088D5 d-proline reductase PACID_24400 ENOG4107T4V d-proline reductase PACID_24420 ENOG4105CTU Proline racemase PACID_24440 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) PACID_24480 ENOG4105UIB (ABC) transporter PACID_24490 ENOG4108JQ9 ABC transporter PACID_24500 ENOG4107TFB basic membrane PACID_24560 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) PACID_24580 ENOG4108EKI Dehydrogenase PACID_24600 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) PACID_24620 ENOG4105DC1 bifunctional purine biosynthesis protein purh PACID_24640 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) PACID_24650 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) PACID_24710 ENOG4105CMV Succinyl-CoA synthetase subunit beta PACID_24760 ENOG4105D01 (LipO)protein PACID_24770 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) PACID_24780 ENOG4108UMI ABC transporter, permease PACID_24800 ENOG4105Y3U Transglycosylase-associated protein PACID_24810 ENOG4105WH1 Two component transcriptional regulator luxr family PACID_24860 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) PACID_24870 ENOG4105D7W serine acetyltransferase PACID_24880 ENOG4105EHE chorismate mutase- prephenate dehydrogenase PACID_24910 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) PACID_24920 ENOG41072RD Membrane PACID_24930 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) PACID_24940 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) PACID_24980 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein PACID_25020 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) PACID_25050 ENOG4108097 ATP-binding protein PACID_25060 ENOG4105C1J atp-dependent rna helicase PACID_25090 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) PACID_25100 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) PACID_25110 ENOG4107QVI Methyltransferase, type 11 PACID_25120 ENOG4105CS9 pantothenic acid kinase PACID_25140 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) PACID_25150 ENOG4107EXU Short-chain dehydrogenase reductase Sdr PACID_25160 ENOG4108UJD 30S ribosomal protein S9 PACID_25170 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) PACID_25190 ENOG4105C0R drug resistance transporter emrb qaca subfamily PACID_25210 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) PACID_25220 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) PACID_25230 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) PACID_25250 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) PACID_25260 ENOG4108JJB ABC transporter PACID_25280 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) PACID_25290 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) PACID_25310 ENOG4108MJN Glycosyl Transferase PACID_25320 ENOG4108ZT0 50S ribosomal protein l17 PACID_25330 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) PACID_25350 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) PACID_25360 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) PACID_25370 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits PACID_25380 ENOG41067V7 50S ribosomal protein L36 PACID_25390 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) PACID_25430 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) PACID_25500 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) PACID_25510 ENOG410849U 50S ribosomal protein L30 PACID_25520 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) PACID_25530 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) PACID_25540 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) PACID_25550 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) PACID_25560 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) PACID_25570 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits PACID_25580 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) PACID_25590 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) PACID_25600 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) PACID_25610 ENOG4105DRS transport system, permease PACID_25650 ENOG4105ETE Transcriptional regulator (LacI family PACID_25670 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal PACID_25680 ENOG41082SA 50s ribosomal protein l29 PACID_25690 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) PACID_25700 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) PACID_25710 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) PACID_25720 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) PACID_25730 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity PACID_25740 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) PACID_25750 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) PACID_25760 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) PACID_25770 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) PACID_25780 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) PACID_25800 ENOG4105CX6 glutaminyL-tRNA synthetase PACID_25830 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) PACID_25850 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) PACID_25860 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) PACID_25870 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) PACID_25880 ENOG4105EE0 oxidoreductase PACID_25910 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) PACID_25920 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) PACID_25930 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) PACID_25940 ENOG4108VZM 50s ribosomal protein L10 PACID_25950 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) PACID_25960 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) PACID_25970 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) PACID_26000 ENOG4105XT2 Transcriptional regulator PACID_26010 ENOG4107R4N Cell wall formation (By similarity) PACID_26030 ENOG410900P UPF0336 protein PACID_26040 ENOG4105WDJ 50S ribosomal protein L33 PACID_26120 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) PACID_26130 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) PACID_26140 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) PACID_26150 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein PACID_26160 ENOG4105DQU oxidoreductase, subunit beta PACID_26170 ENOG4105C9K Endothelin-converting enzyme 1 PACID_26190 ENOG41062B0 ABC transporter, permease PACID_26200 ENOG4107R9N ABC transporter PACID_26210 ENOG4105C2J ABC transporter PACID_26220 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator PACID_26240 ENOG4107FQ9 ethanolamine ammonia-lyase PACID_26250 ENOG4105CPD ethanolamine ammonia-lyase PACID_26280 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) PACID_26310 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) PACID_26320 ENOG4105DF2 NADH dehydrogenase subunit j PACID_26330 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) PACID_26340 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) PACID_26350 ENOG4108IEH NADH dehydrogenase subunit g PACID_26360 ENOG4107QIZ NADH dehydrogenase PACID_26380 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) PACID_26390 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain PACID_26400 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) PACID_26420 ENOG4105P52 geranylgeranyl reductase PACID_26430 ENOG4105E4F Isochorismate synthase PACID_26480 ENOG4105CJ1 ABC, transporter PACID_26490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) PACID_26510 ENOG4105BZ1 (ABC) transporter PACID_26550 ENOG4105CMT Dihydroxyacetone kinase PACID_26560 ENOG4108UTZ Dihydroxyacetone kinase PACID_26570 ENOG4105VDH Dihydroxyacetone kinase PACID_26600 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) PACID_26650 ENOG4105DEN Luciferase family PACID_26780 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) PACID_26810 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) PACID_27030 ENOG4108IV0 ABC, transporter PACID_27040 ENOG4105C0Z ABC transporter PACID_27050 ENOG4105CF8 branched-chain amino acid ABC transporter, permease PACID_27060 ENOG4105C32 Amino acid ABC transporter (Permease) PACID_27070 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component PACID_27120 ENOG4105CXB phosphoribosylaminoimidazole synthetase PACID_27150 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) PACID_27200 ENOG4107QIK phosphoribosylformylglycinamidine synthase PACID_27230 ENOG4105HDK L-asparaginase PACID_27260 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) PACID_27270 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I PACID_27280 ENOG4105C8V SAICAR synthetase PACID_27290 ENOG4105D3R alkyl hydroperoxide reductase PACID_27300 ENOG4108JU3 Alkyl hydroperoxide reductase PACID_27320 ENOG4105C83 adenylosuccinate lyase PACID_27330 ENOG4105C12 Phosphoribosylglycinamide synthetase PACID_27350 ENOG4105VJK Transcription factor PACID_27360 ENOG4105ZGE Toxic component of a toxin-antitoxin (TA) module. A PACID_27370 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis PACID_27400 ENOG4105XTG Pfam:DUF156 PACID_27410 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase PACID_27440 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) PACID_27450 ENOG4105CI3 gtp-binding protein typa PACID_27490 ENOG4108SVG May play a role in the intracellular transport of hydrophobic ligands PACID_27510 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) PACID_27570 ENOG4107NHD transcriptional regulator PACID_27580 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) PACID_27630 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) PACID_27640 ENOG4105KDC 50s ribosomal protein l28 PACID_27670 ENOG41068HZ 50S ribosomal protein L32 PACID_27690 ENOG4105NRA 50s ribosomal protein l31 type b PACID_27700 ENOG4105W0E 50S ribosomal protein L33 PACID_27720 ENOG4105CKI cobalamin synthesis protein PACID_27750 ENOG4105CC5 ABC transporter PACID_27760 ENOG4105DIK (ABC) transporter PACID_27780 ENOG4105DSE periplasmic solute binding protein PACID_27790 ENOG4108MES Periplasmic binding protein PACID_27800 ENOG4105DQ5 transport system permease protein PACID_27810 ENOG4108IHU transport system permease protein PACID_27820 ENOG4105E0A ABC, transporter PACID_27860 ENOG4105C01 Dihydroxy-acid dehydratase PACID_27870 ENOG4105C7B Threonine dehydratase PACID_27900 ENOG4105C6V Glycerol-3-phosphate dehydrogenase PACID_27940 ENOG4105CRE cytochrome C PACID_27960 ENOG4107QIV Cytochrome c biogenesis protein PACID_27970 ENOG4107ZT5 Thiol disulfide interchange protein PACID_27980 ENOG4108RH7 phosphoglycerate mutase PACID_27990 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) PACID_28010 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) PACID_28030 ENOG4105II7 pyrroline-5-carboxylate reductase PACID_28070 ENOG4105EY0 Xylose isomerase domain protein TIM barrel PACID_28090 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) PACID_28100 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) PACID_28130 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) PACID_28140 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) PACID_28150 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) PACID_28170 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) PACID_28200 ENOG4105D52 delta-aminolevulinic acid dehydratase PACID_28210 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase PACID_28220 ENOG4105CEN a g-specific adenine glycosylase PACID_28240 ENOG4108UCS ABC, transporter PACID_28260 ENOG4105DP9 ABC transporter PACID_28400 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit PACID_28420 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) PACID_28460 ENOG4105KRF dihydroneopterin aldolase PACID_28470 ENOG4105EEI dihydropteroate synthase PACID_28480 ENOG4105EUJ GTP cyclohydrolase i PACID_28500 ENOG4108UGV hypoxanthine phosphoribosyltransferase PACID_28510 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) PACID_28530 ENOG4105F0N pyrophosphate phospho-hydrolase PACID_28550 ENOG4105I82 acetyl xylan esterase PACID_28560 ENOG4105M4E phosphohistidine phosphatase, SixA PACID_28660 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A PACID_28680 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PACID_28690 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component PACID_28730 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) PACID_28740 ENOG4108YYH Nadph-dependent fmn reductase PACID_28830 ENOG4105MA4 psp1 domain protein PACID_28850 ENOG4105C6E dna polymerase iii PACID_28860 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) PACID_28880 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) PACID_28900 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) PACID_28920 ENOG4108I5C dEAD DEAH box helicase PACID_29100 ENOG4105P8F nudix hydrolase PACID_29170 ENOG4105BZ4 penicillin-binding protein PACID_29220 ENOG4108IQI permease PACID_29230 ENOG4107QK5 Homocysteine s-methyltransferase PACID_29240 ENOG410834F Transcriptional regulator PACID_29310 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component PACID_29320 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PACID_29330 ENOG4105C3U ABC transporter PACID_29340 ENOG4108JQ7 (ABC) transporter PACID_29370 ENOG4105D1Q UPF0246 protein PACID_29400 ENOG4108HMQ sugar kinase PACID_29410 ENOG4107Z1W Fructose transport system kinase PACID_29440 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) PACID_29460 ENOG4107QI1 Mate efflux family protein PACID_29540 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) PACID_29560 ENOG4105WH1 Two component transcriptional regulator luxr family PACID_29570 ENOG4105CH6 catalase PACID_29610 ENOG4105DQE DNA ligase PACID_29630 ENOG4105CYX Short-chain dehydrogenase reductase Sdr PACID_29660 ENOG41061TZ Short-chain dehydrogenase reductase Sdr PACID_29680 ENOG4107S2Z UPF0761 membrane protein PACID_29720 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) PACID_29770 ENOG4105WS7 Cation transport regulator PACID_29780 ENOG4107SET aldo keto reductase PACID_29810 ENOG4105DFH Transport of potassium into the cell (By similarity) PACID_29880 ENOG41060M0 Crispr-associated protein, cse4 family PACID_29910 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) PACID_29920 ENOG4105PWE CRISPR-associated protein cas2 PACID_29990 ENOG4105CSH Transporter PACID_30000 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) PACID_30020 ENOG4105DQR SNARE associated Golgi PACID_30040 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) PACID_30050 ENOG4105BZU Histidine kinase PACID_30060 ENOG4105ETX regulatoR PACID_30070 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) PACID_30090 ENOG4105C4B ABC transporter, permease PACID_30110 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PACID_30130 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) PACID_30150 ENOG4105EMU Dehydrogenase PACID_30170 ENOG4105C2X Arabinose 5-phosphate isomerase PACID_30220 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component PACID_30240 ENOG4105ETE Transcriptional regulator (LacI family PACID_30250 ENOG4105EF1 ribulokinase PACID_30260 ENOG4105DQ4 alcohol dehydrogenase PACID_30270 ENOG4105DKT Transcriptional regulator PACID_30280 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) PACID_30290 ENOG4105CPQ Dehydrogenase PACID_30310 ENOG4105C29 acyl-CoA thioesterase PACID_30330 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) PACID_30340 ENOG41090U3 tautomerase PACID_30400 ENOG4108UMN azlc family PACID_30440 ENOG4105D7A ATP-binding protein PACID_30470 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) PACID_30490 ENOG4108IJ8 ABC transporter PACID_30510 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component PACID_30530 ENOG4107S1E Beta-lactamase PACID_30630 ENOG4108Z6B deaminase PACID_30650 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) PACID_30730 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein PACID_30740 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein PACID_30750 ENOG4108QXE glycerophosphoryl diester phosphodiesterase PACID_30800 ENOG4108KGH TRANSCRIPTIONal PACID_30810 ENOG4105ETE Transcriptional regulator (LacI family PACID_30820 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) PACID_30900 ENOG4105CDH Citrulline--aspartate ligase PACID_30940 ENOG4108K4B hydrolase PACID_30990 ENOG4105EG2 ABC transporter, permease PACID_31020 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) PACID_31060 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) PACID_31080 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) PACID_31100 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 PACID_31110 ENOG4105CPP Dehydrogenase, E1 component PACID_31200 ENOG4105CSH Transporter PACID_31210 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) PACID_31220 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PACID_31230 ENOG4105ENR peptidase, M24 PACID_31250 ENOG4108JPW Aminotransferase PACID_31310 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) PACID_31320 ENOG4105C5I Dehydrogenase PACID_31460 ENOG4106H3A restriction PACID_31530 ENOG4105GR3 Histidine kinase PACID_31560 ENOG4108HKT sucrose-6-phosphate hydrolase PACID_31570 ENOG4105DKT Transcriptional regulator PACID_31580 ENOG4105CMG Carbohydrate kinase PACID_31590 ENOG4105CMG Carbohydrate kinase PACID_31610 ENOG4107W7X Aldolase PACID_31620 ENOG4105CV8 reductase PACID_31630 ENOG41061GT Aldolase PACID_31640 ENOG4105CPQ Dehydrogenase PACID_31660 ENOG4105CSH Transporter PACID_31710 ENOG4105DSQ Nitric oxide reductase PACID_31780 ENOG4107QWR cellulase (EC 3.2.1.4) PACID_31800 ENOG4105CG3 alpha amylase, catalytic region PACID_31860 ENOG4107QK4 glycoside hydrolase, family 3 domain protein PACID_31870 ENOG4105CG3 alpha amylase, catalytic region PACID_31890 ENOG4105BZ7 extracellular solute-binding protein family 1 PACID_31900 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component PACID_31910 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component PACID_31930 ENOG4105KT7 mgtC SapB transporter PACID_31960 ENOG4105EBR Carboxylesterase PACID_31970 ENOG4105DKQ ROK family PACID_31990 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component PACID_32000 ENOG4105DRS transport system, permease PACID_32020 ENOG4105CG3 alpha amylase, catalytic region PACID_32050 ENOG4105BZ1 (ABC) transporter PACID_32060 ENOG4105BZ1 (ABC) transporter PACID_32090 ENOG4105CIF Ornithine Cyclodeaminase PACID_32130 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component PACID_32160 ENOG4105ETE Transcriptional regulator (LacI family PACID_32190 ENOG41062D9 Histidine kinase PACID_32210 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) PACID_32230 ENOG4105PGM cation diffusion facilitator family transporter PACID_32260 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase PACID_32290 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) PACID_32320 ENOG4105K9Q Binds to the 23S rRNA (By similarity) PACID_32330 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) PACID_32350 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) PACID_32360 ENOG4105DBE peroxidase PACID_32400 ENOG4108IQE Amp-dependent synthetase and ligase PACID_32430 ENOG4108IXY short-chain dehydrogenase reductase PACID_32520 ENOG4105CQB FAD linked oxidase domain protein PACID_32560 ENOG4105WH1 Two component transcriptional regulator luxr family PACID_32570 ENOG4108U8T Mannosyltransferase PACID_32580 ENOG4105CJ1 ABC, transporter PACID_32670 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) PACID_32680 ENOG4105BZU Histidine kinase PACID_32690 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) PACID_32700 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B PACID_32710 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A PACID_32720 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes PACID_32730 ENOG4105C5I Dehydrogenase PACID_32750 ENOG4105C85 amino acid PACID_32830 ENOG4107QI1 Mate efflux family protein PACID_32870 ENOG4108TFM Kinase, PfkB family PACID_32890 ENOG4108Z66 YbaK ebsC protein PACID_32910 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component PACID_32930 ENOG4105ETE Transcriptional regulator (LacI family PACID_32960 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) PACID_33010 ENOG4108HKT sucrose-6-phosphate hydrolase PACID_33020 ENOG4105D7K pfkb domain protein PACID_33030 ENOG410839S Toxic component of a toxin-antitoxin (TA) module (By similarity) PACID_33050 ENOG4106FRU abrb family transcriptional regulator PACID_33080 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit PACID_33100 ENOG4105IDI abc transporter atp-binding protein PACID_33110 ENOG4108QVN serine threonine protein kinase PACID_33140 ENOG4105CTQ phosphohexokinase PACID_33150 ENOG4105DCF alanine dehydrogenase PACID_33160 ENOG4105E5G Alpha beta hydrolase fold PACID_33250 ENOG4107UBC ErfK ybiS ycfS ynhG family protein PACID_33260 ENOG4105K6T rare lipoprotein A PACID_33280 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) PACID_33320 ENOG4105E2D ec 3.2.1.52 PACID_33380 ENOG4105CMQ Chloride channel PACID_33400 ENOG4105CAG UPF0210 protein PACID_33440 ENOG4105C9Q fumarate hydratase class II PACID_33460 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) PACID_33470 ENOG41064HX Suppressor of fused protein (SUFU) PACID_33490 ENOG4105CTZ aminopeptidase c PACID_33500 ENOG4105CIG ABC transporter PACID_33530 ENOG4105F27 Major Facilitator PACID_33550 ENOG4105E98 transcriptional regulator DeoR family PACID_33560 ENOG4105CXT aspartate transcarbamylase PACID_33590 ENOG4105D8X mechanosensitive ion channel PACID_33600 ENOG4105BZW Glycerate kinase PACID_33620 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate PACID_33630 ENOG4105C26 Dehydrogenase PACID_33640 ENOG4105C09 Bile acid PACID_33650 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein PACID_33710 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) PACID_33730 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) PACID_33740 ENOG4107RHR regulatoR PACID_33760 ENOG4105C0H protease PACID_33790 ENOG4105DRS transport system, permease PACID_33810 ENOG4108JE9 extracellular solute-binding protein family 1 PACID_33840 ENOG4105ETE Transcriptional regulator (LacI family PACID_33850 ENOG4105C3M thioredoxin reductase PACID_33860 ENOG4105KVH Transcriptional regulator PACID_33890 ENOG4105K63 Thioredoxin PACID_33940 ENOG4108XG2 Histidine kinase PACID_33960 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) PACID_33980 ENOG4107QP6 Xylose isomerase domain protein TIM barrel PACID_33990 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) PACID_34000 ENOG4105ETE Transcriptional regulator (LacI family PACID_34020 ENOG4107ZR7 Membrane PACID_34050 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) PACID_34080 ENOG4107QNK )-transporter PACID_34090 ENOG4107QNK )-transporter PACID_34100 ENOG4105ETE Transcriptional regulator (LacI family PACID_34110 ENOG4107QNK )-transporter PACID_34120 ENOG4105ETE Transcriptional regulator (LacI family PACID_34130 ENOG4105F0H myo-inositol catabolism protein PACID_34140 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) PACID_34150 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) PACID_34160 ENOG4105C26 Dehydrogenase PACID_34190 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PACID_34210 ENOG4105CPF Cell wall formation (By similarity) PACID_34240 ENOG4105DQE DNA ligase PACID_34260 ENOG4107QJE Chromosome Partitioning Protein PACID_34280 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) PACID_34290 ENOG4105KPY Small multidrug resistance protein PACID_34310 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins PACID_34320 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) PACID_34330 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)