locus-tag	class	description
AXH35_00115	COG1388	LysM domain
AXH35_00115	COG3942	CHAP domain
AXH35_00210	COG3711	transcriptional antiterminator
AXH35_00210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXH35_00295	COG0732	type I restriction modification DNA specificity domain
AXH35_00320	COG4974	Belongs to the 'phage' integrase family
AXH35_00370	COG2801	Transposase and inactivated derivatives
AXH35_00375	COG2963	transposase activity
AXH35_00385	COG1309	transcriptional regulator
AXH35_00395	COG2130	NADP-dependent
AXH35_00400	COG2801	Transposase and inactivated derivatives
AXH35_00460	COG1280	lysine exporter protein (LysE YggA)
AXH35_00465	COG1522	sequence-specific DNA binding
AXH35_00500	COG0488	(ABC) transporter
AXH35_00575	COG0590	tRNA wobble adenosine to inosine editing
AXH35_00580	COG1063	alcohol dehydrogenase
AXH35_00585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AXH35_00600	COG0495	leucyl-tRNA aminoacylation
AXH35_00610	COG2333	competence protein COMEC
AXH35_00610	COG0658	competence protein
AXH35_00615	COG1061	Type III restriction enzyme res subunit
AXH35_00625	COG0268	Binds directly to 16S ribosomal RNA
AXH35_00635	COG0481	GTPase activity
AXH35_00655	COG4948	Mandelate Racemase Muconate Lactonizing
AXH35_00660	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AXH35_00665	COG1169	isochorismate synthase
AXH35_00675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AXH35_00685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AXH35_00690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AXH35_00700	COG1131	(ABC) transporter
AXH35_00710	COG0477	Major facilitator Superfamily
AXH35_00720	COG0395	ABC-type sugar transport system, permease component
AXH35_00725	COG1175	transmembrane transport
AXH35_00745	COG0483	inositol monophosphate 1-phosphatase activity
AXH35_00765	COG1420	regulation of RNA biosynthetic process
AXH35_00770	COG0484	heat shock protein binding
AXH35_00780	COG1063	alcohol dehydrogenase
AXH35_00785	COG2213	PTS system mannitol-specific
AXH35_00785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXH35_00800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AXH35_00805	COG5006	permease, DMT superfamily
AXH35_00810	COG0343	queuine tRNA-ribosyltransferase activity
AXH35_00820	COG2197	response regulator
AXH35_00825	COG4152	abc transporter atp-binding protein
AXH35_00850	COG0596	Alpha beta hydrolase
AXH35_00865	COG2226	methyltransferase
AXH35_00885	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AXH35_00895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AXH35_00905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXH35_00910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXH35_00915	COG0765	amino acid transport
AXH35_00930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXH35_00940	COG1404	Belongs to the peptidase S8 family
AXH35_00945	COG1381	Involved in DNA repair and RecF pathway recombination
AXH35_00955	COG4716	Myosin-crossreactive antigen
AXH35_00980	COG0647	UMP catabolic process
AXH35_00985	COG1268	BioY protein
AXH35_00990	COG1122	ATPase activity
AXH35_01005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AXH35_01010	COG0497	DNA recombination
AXH35_01015	COG0504	CTP synthase activity
AXH35_01050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXH35_01070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AXH35_01090	COG0107	imidazoleglycerol-phosphate synthase activity
AXH35_01095	COG0537	adenosine 5'-monophosphoramidase activity
AXH35_01105	COG0440	acetolactate synthase activity
AXH35_01110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AXH35_01130	COG0473	3-isopropylmalate dehydrogenase activity
AXH35_01135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AXH35_01140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXH35_01150	COG0179	Fumarylacetoacetate (FAA) hydrolase
AXH35_01170	COG1414	Transcriptional regulator
AXH35_01175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AXH35_01180	COG0066	3-isopropylmalate dehydratase activity
AXH35_01190	COG1181	Belongs to the D-alanine--D-alanine ligase family
AXH35_01205	COG1674	ftsk spoiiie
AXH35_01215	COG3152	Membrane
AXH35_01230	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AXH35_01235	COG2884	Cell division ATP-binding protein ftsE
AXH35_01240	COG2177	Part of the ABC transporter FtsEX involved in
AXH35_01245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AXH35_01250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AXH35_01260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AXH35_01270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AXH35_01275	COG0165	Argininosuccinate lyase
AXH35_01290	COG1678	Uncharacterized ACR, COG1678
AXH35_01295	COG0745	RESPONSE REGULATOR receiver
AXH35_01300	COG5002	protein histidine kinase activity
AXH35_01305	COG5401	PFAM Sporulation and spore germination
AXH35_01315	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AXH35_01325	COG0653	protein targeting
AXH35_01345	COG0613	PHP domain protein
AXH35_01355	COG0180	Tryptophanyl-tRNA synthetase
AXH35_01380	COG1278	Cold shock
AXH35_01385	COG0210	DNA helicase
AXH35_01405	COG1074	ATP-dependent DNA helicase activity
AXH35_01410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AXH35_01435	COG3480	Lon protease (S16) C-terminal proteolytic domain
AXH35_01445	COG1615	UPF0182 protein
AXH35_01475	COG0747	negative chemotaxis
AXH35_01500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXH35_01505	COG0483	inositol monophosphate 1-phosphatase activity
AXH35_01515	COG1162	GTPase activity
AXH35_01520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AXH35_01530	COG1595	DNA-templated transcription, initiation
AXH35_01555	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXH35_01555	COG0567	Dehydrogenase, E1 component
AXH35_01565	COG1611	Belongs to the LOG family
AXH35_01575	COG0019	diaminopimelate decarboxylase activity
AXH35_01580	COG0460	homoserine dehydrogenase
AXH35_01585	COG0083	homoserine kinase activity
AXH35_01595	COG0254	rRNA binding
AXH35_01600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AXH35_01605	COG2890	protein-(glutamine-N5) methyltransferase activity
AXH35_01685	COG0318	PFAM AMP-dependent synthetase and ligase
AXH35_01695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AXH35_01700	COG0367	asparagine synthase
AXH35_01710	COG1045	serine acetyltransferase
AXH35_01725	COG0356	it plays a direct role in the translocation of protons across the membrane
AXH35_01730	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXH35_01735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AXH35_01740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXH35_01745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AXH35_01750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AXH35_01755	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AXH35_01760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AXH35_01815	COG0033	Phosphoglucomutase
AXH35_01825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AXH35_01840	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AXH35_01845	COG3281	Trehalose synthase
AXH35_01850	COG0366	Alpha amylase catalytic
AXH35_01870	COG0482	sulfurtransferase activity
AXH35_01885	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AXH35_01895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AXH35_01910	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXH35_01915	COG0154	amidase activity
AXH35_01920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXH35_01940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AXH35_01945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AXH35_01960	COG0134	indole-3-glycerol-phosphate synthase activity
AXH35_01970	COG0159	tryptophan synthase activity
AXH35_01975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AXH35_01980	COG0069	glutamate synthase activity
AXH35_01980	COG0067	glutamate synthase
AXH35_01980	COG0070	glutamate synthase
AXH35_02000	COG0395	ABC-type sugar transport system, permease component
AXH35_02035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AXH35_02040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AXH35_02045	COG0131	Imidazoleglycerol-phosphate dehydratase
AXH35_02050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AXH35_02055	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AXH35_02060	COG0217	transcriptional regulatory protein
AXH35_02065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AXH35_02070	COG0632	four-way junction helicase activity
AXH35_02075	COG2255	four-way junction helicase activity
AXH35_02085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXH35_02090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXH35_02095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AXH35_02105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXH35_02110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AXH35_02115	COG1196	nuclear chromosome segregation
AXH35_02120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXH35_02125	COG0124	histidyl-tRNA synthetase
AXH35_02135	COG1309	transcriptional regulator
AXH35_02150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AXH35_02185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AXH35_02190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AXH35_02195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AXH35_02200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AXH35_02205	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AXH35_02210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AXH35_02215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AXH35_02225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AXH35_02230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXH35_02240	COG0194	GDP metabolic process
AXH35_02245	COG1758	RNA polymerase activity
AXH35_02255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AXH35_02260	COG1201	RNA secondary structure unwinding
AXH35_02265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AXH35_02295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AXH35_02305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AXH35_02315	COG1410	methionine synthase
AXH35_02315	COG0646	methionine synthase
AXH35_02330	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AXH35_02335	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AXH35_02345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AXH35_02350	COG1160	GTP binding
AXH35_02360	COG1764	response to oxidative stress
AXH35_02385	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AXH35_02480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AXH35_02490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXH35_02510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXH35_02520	COG0277	FAD linked oxidase domain protein
AXH35_02580	COG3550	peptidyl-serine autophosphorylation
AXH35_02610	COG2807	transmembrane transport
AXH35_02630	COG0427	acetyl-CoA hydrolase
AXH35_02635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AXH35_02640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AXH35_02640	COG2813	Specifically methylates the guanine in position
AXH35_02645	COG1522	sequence-specific DNA binding
AXH35_02650	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AXH35_02655	COG1216	Glycosyl transferase, family 2
AXH35_02670	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AXH35_02675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AXH35_02685	COG1966	Carbon starvation protein
AXH35_02700	COG0531	amino acid
AXH35_02750	COG1739	Uncharacterized protein family UPF0029
AXH35_02755	COG1472	Belongs to the glycosyl hydrolase 3 family
AXH35_02760	COG1597	lipid kinase activity
AXH35_02765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AXH35_02770	COG0009	L-threonylcarbamoyladenylate synthase
AXH35_02780	COG0205	6-phosphofructokinase activity
AXH35_02785	COG1295	ribonuclease BN
AXH35_02805	COG1716	ATPase activity
AXH35_02835	COG0438	transferase activity, transferring glycosyl groups
AXH35_02840	COG1560	Kdo2-lipid A biosynthetic process
AXH35_02855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AXH35_02860	COG1064	alcohol dehydrogenase
AXH35_02885	COG0726	polysaccharide deacetylase
AXH35_02915	COG2326	polyphosphate kinase activity
AXH35_02920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXH35_02935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AXH35_02940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AXH35_02945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AXH35_02950	COG0531	amino acid
AXH35_02955	COG0569	domain protein
AXH35_02975	COG0756	dUTP diphosphatase activity
AXH35_03010	COG1297	OPT oligopeptide transporter protein
AXH35_03020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXH35_03040	COG0187	DNA topoisomerase II activity
AXH35_03055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AXH35_03065	COG1643	Atp-dependent helicase
AXH35_03085	COG0717	Belongs to the dCTP deaminase family
AXH35_03090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AXH35_03110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AXH35_03115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AXH35_03120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AXH35_03435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXH35_03440	COG2017	converts alpha-aldose to the beta-anomer
AXH35_03445	COG1418	mRNA catabolic process
AXH35_03450	COG2137	regulation of response to DNA damage stimulus
AXH35_03465	COG1349	DNA-binding transcription factor activity
AXH35_03475	COG1058	Belongs to the CinA family
AXH35_03475	COG1546	Belongs to the CinA family
AXH35_03485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXH35_03515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AXH35_03520	COG0284	orotidine-5'-phosphate decarboxylase activity
AXH35_03525	COG0167	dihydroorotate dehydrogenase activity
AXH35_03530	COG0543	2 iron, 2 sulfur cluster binding
AXH35_03535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AXH35_03540	COG0505	Belongs to the CarA family
AXH35_03545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AXH35_03560	COG0667	Aldo Keto reductase
AXH35_03570	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AXH35_03585	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AXH35_03595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AXH35_03600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AXH35_03625	COG2304	oxidoreductase activity
AXH35_03635	COG0714	Associated with various cellular activities
AXH35_03665	COG0477	Major facilitator Superfamily
AXH35_03670	COG1309	transcriptional regulator
AXH35_03675	COG0515	serine threonine protein kinase
AXH35_03685	COG0583	DNA-binding transcription factor activity
AXH35_03695	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AXH35_03705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXH35_03725	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AXH35_03750	COG1191	sigma factor activity
AXH35_03755	COG0358	DNA primase activity
AXH35_03760	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AXH35_03785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AXH35_03790	COG1053	succinate dehydrogenase
AXH35_03800	COG0076	glutamate decarboxylase activity
AXH35_03810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AXH35_03815	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AXH35_03825	COG0423	glycine-tRNA ligase activity
AXH35_03835	COG0735	belongs to the Fur family
AXH35_03870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AXH35_03875	COG0140	phosphoribosyl-ATP diphosphatase activity
AXH35_03880	COG3201	nicotinamide mononucleotide transporter
AXH35_03890	COG0667	Aldo Keto reductase
AXH35_03900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AXH35_03910	COG1609	Transcriptional regulator
AXH35_03915	COG2160	L-arabinose isomerase activity
AXH35_03945	COG0395	ABC-type sugar transport system, permease component
AXH35_03955	COG1609	Transcriptional regulator
AXH35_03960	COG0395	ABC-type sugar transport system, permease component
AXH35_03965	COG1175	transmembrane transport
AXH35_03990	COG0606	chelatase, subunit chli
AXH35_03995	COG0792	nuclease activity
AXH35_04005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AXH35_04010	COG0681	Belongs to the peptidase S26 family
AXH35_04015	COG0335	large ribosomal subunit rRNA binding
AXH35_04020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AXH35_04025	COG1053	succinate dehydrogenase
AXH35_04035	COG0336	Belongs to the RNA methyltransferase TrmD family
AXH35_04040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AXH35_04045	COG1837	Belongs to the UPF0109 family
AXH35_04050	COG0228	four-way junction DNA binding
AXH35_04125	COG0656	L-ascorbic acid biosynthetic process
AXH35_04130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AXH35_04135	COG0571	ribonuclease III activity
AXH35_04140	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AXH35_04150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AXH35_04155	COG0742	ribosomal rna small subunit methyltransferase
AXH35_04175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXH35_04180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AXH35_04190	COG0028	Belongs to the TPP enzyme family
AXH35_04200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AXH35_04205	COG1185	polyribonucleotide nucleotidyltransferase activity
AXH35_04210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AXH35_04230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AXH35_04250	COG3732	PTS system glucitol sorbitol-specific
AXH35_04265	COG0371	Dehydrogenase
AXH35_04270	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AXH35_04280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AXH35_04290	COG0195	Participates in both transcription termination and antitermination
AXH35_04295	COG0779	Required for maturation of 30S ribosomal subunits
AXH35_04315	COG0442	prolyl-tRNA aminoacylation
AXH35_04325	COG1305	Transglutaminase-like
AXH35_04355	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AXH35_04360	COG0750	zinc metalloprotease
AXH35_04370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AXH35_04375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AXH35_04380	COG0575	Belongs to the CDS family
AXH35_04385	COG0233	cytoplasmic translational termination
AXH35_04390	COG0528	UMP kinase activity
AXH35_04395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AXH35_04400	COG0052	Belongs to the universal ribosomal protein uS2 family
AXH35_04405	COG3831	ATPase activity
AXH35_04420	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AXH35_04435	COG4974	Belongs to the 'phage' integrase family
AXH35_04445	COG0242	peptide deformylase activity
AXH35_04485	COG1119	ATPase activity
AXH35_04490	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AXH35_04515	COG1028	Short-chain dehydrogenase reductase Sdr
AXH35_04545	COG0488	(ABC) transporter
AXH35_04560	COG0110	maltose O-acetyltransferase activity
AXH35_04595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AXH35_04600	COG0396	ATPase activity
AXH35_04615	COG0719	Fe-S assembly protein
AXH35_04630	COG1175	transmembrane transport
AXH35_04635	COG3833	ABC-type maltose transport systems, permease component
AXH35_04640	COG1609	Transcriptional regulator
AXH35_04645	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AXH35_04650	COG1131	(ABC) transporter
AXH35_04660	COG1612	heme a metabolic process
AXH35_04665	COG0109	protoheme IX farnesyltransferase activity
AXH35_04680	COG0363	glucosamine-6-phosphate deaminase activity
AXH35_04690	COG0525	valine-tRNA ligase activity
AXH35_04705	COG0793	Belongs to the peptidase S41A family
AXH35_04705	COG4946	Tricorn protease homolog
AXH35_04715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AXH35_04720	COG0740	serine-type endopeptidase activity
AXH35_04725	COG0740	serine-type endopeptidase activity
AXH35_04735	COG0544	peptidyl-prolyl cis-trans isomerase activity
AXH35_04755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AXH35_04755	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AXH35_04775	COG0698	ribose 5-phosphate isomerase
AXH35_04790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXH35_04795	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AXH35_04810	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AXH35_04820	COG2814	Major facilitator Superfamily
AXH35_04835	COG1022	Amp-dependent synthetase and ligase
AXH35_04850	COG0277	FAD linked oxidase domain protein
AXH35_04850	COG0247	lactate metabolic process
AXH35_04875	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AXH35_04885	COG4106	trans-aconitate 2-methyltransferase activity
AXH35_04895	COG0519	Catalyzes the synthesis of GMP from XMP
AXH35_04900	COG1794	racemase activity, acting on amino acids and derivatives
AXH35_04920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AXH35_04930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AXH35_04935	COG2197	response regulator
AXH35_04940	COG4585	Histidine kinase
AXH35_04950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AXH35_04960	COG1113	amino acid transport
AXH35_04975	COG1131	(ABC) transporter
AXH35_04995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXH35_05000	COG0531	amino acid
AXH35_05010	COG0587	DNA-directed DNA polymerase activity
AXH35_05025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXH35_05050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AXH35_05075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXH35_05085	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AXH35_05090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AXH35_05095	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AXH35_05100	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AXH35_05110	COG1918	ferrous iron import across plasma membrane
AXH35_05110	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AXH35_05125	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AXH35_05205	COG0662	Cupin 2, conserved barrel domain protein
AXH35_05205	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AXH35_05220	COG1316	TRANSCRIPTIONal
AXH35_05240	COG3340	Belongs to the peptidase S51 family
AXH35_05250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AXH35_05260	COG0424	maF-like protein
AXH35_05275	COG4221	oxidoreductase activity
AXH35_05285	COG0351	phosphomethylpyrimidine kinase
AXH35_05295	COG4770	biotin carboxylase activity
AXH35_05315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXH35_05330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXH35_05335	COG4656	Part of a membrane complex involved in electron transport
AXH35_05340	COG0252	asparaginase activity
AXH35_05340	COG5275	peptidyl-tyrosine sulfation
AXH35_05350	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AXH35_05370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXH35_05410	COG1253	flavin adenine dinucleotide binding
AXH35_05430	COG0039	L-malate dehydrogenase activity
AXH35_05445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AXH35_05455	COG0138	bifunctional purine biosynthesis protein purh
AXH35_05465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AXH35_05470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXH35_05470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXH35_05500	COG0045	succinate-CoA ligase (ADP-forming) activity
AXH35_05520	COG1464	Belongs to the NlpA lipoprotein family
AXH35_05525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AXH35_05530	COG2011	ABC-type metal ion transport system permease component
AXH35_05540	COG2261	transglycosylase associated protein
AXH35_05545	COG2197	response regulator
AXH35_05570	COG0519	Catalyzes the synthesis of GMP from XMP
AXH35_05570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXH35_05575	COG1045	serine acetyltransferase
AXH35_05580	COG0287	Prephenate dehydrogenase
AXH35_05580	COG1605	Chorismate mutase
AXH35_05600	COG0459	protein refolding
AXH35_05605	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AXH35_05625	COG1355	regulation of microtubule-based process
AXH35_05645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AXH35_05655	COG1214	PFAM Peptidase M22, glycoprotease
AXH35_05655	COG0456	acetyltransferase
AXH35_05660	COG0802	atpase or kinase
AXH35_05665	COG0513	Belongs to the DEAD box helicase family
AXH35_05680	COG0736	holo-[acyl-carrier-protein] synthase activity
AXH35_05685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AXH35_05695	COG1072	(Pantothenic acid kinase))
AXH35_05705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXH35_05715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AXH35_05720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AXH35_05740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AXH35_05745	COG0101	tRNA pseudouridine synthase activity
AXH35_05760	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AXH35_05765	COG3845	ABC transporter
AXH35_05780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXH35_05780	COG0519	Catalyzes the synthesis of GMP from XMP
AXH35_05790	COG0438	transferase activity, transferring glycosyl groups
AXH35_05795	COG0203	ribosomal protein L17
AXH35_05800	COG0202	RNA polymerase activity
AXH35_05805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AXH35_05810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AXH35_05815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AXH35_05820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AXH35_05825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AXH35_05845	COG0563	adenylate kinase activity
AXH35_05880	COG0200	Binds to the 23S rRNA
AXH35_05885	COG1841	ribosomal large subunit assembly
AXH35_05890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AXH35_05895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AXH35_05900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AXH35_05905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AXH35_05910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AXH35_05915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AXH35_05920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AXH35_05925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AXH35_05930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXH35_05935	COG0395	ABC-type sugar transport system, permease component
AXH35_05940	COG1175	transmembrane transport
AXH35_05960	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AXH35_05965	COG0255	Belongs to the universal ribosomal protein uL29 family
AXH35_05970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AXH35_05975	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AXH35_05980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AXH35_05985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AXH35_05990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AXH35_05995	COG0089	rRNA binding
AXH35_06000	COG0088	Forms part of the polypeptide exit tunnel
AXH35_06005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AXH35_06010	COG0051	transcription antitermination factor activity, RNA binding
AXH35_06015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXH35_06020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXH35_06035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AXH35_06040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AXH35_06045	COG0049	tRNA binding
AXH35_06050	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AXH35_06055	COG0673	inositol 2-dehydrogenase activity
AXH35_06070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AXH35_06075	COG0085	RNA polymerase activity
AXH35_06080	COG0222	ribosome binding
AXH35_06090	COG0081	regulation of translation
AXH35_06095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AXH35_06100	COG0250	Participates in transcription elongation, termination and antitermination
AXH35_06115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXH35_06120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AXH35_06130	COG2030	dehydratase
AXH35_06135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXH35_06175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH35_06180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH35_06180	COG0649	NAD binding
AXH35_06185	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH35_06190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AXH35_06190	COG0674	pyruvate-flavodoxin oxidoreductase activity
AXH35_06195	COG1013	pyruvate-flavodoxin oxidoreductase activity
AXH35_06200	COG3590	peptidase
AXH35_06255	COG1007	ATP synthesis coupled electron transport
AXH35_06270	COG0713	ATP synthesis coupled electron transport
AXH35_06280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH35_06285	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AXH35_06290	COG1034	ATP synthesis coupled electron transport
AXH35_06295	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AXH35_06305	COG0649	NAD binding
AXH35_06310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH35_06315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH35_06325	COG0644	oxidoreductase
AXH35_06350	COG1131	(ABC) transporter
AXH35_06355	COG2226	methyltransferase
AXH35_06365	COG1132	(ABC) transporter
AXH35_06385	COG2376	Dihydroxyacetone kinase
AXH35_06390	COG1461	Dihydroxyacetone kinase
AXH35_06395	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AXH35_06395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXH35_06395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXH35_06415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AXH35_06435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXH35_06445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXH35_06490	COG0574	Belongs to the PEP-utilizing enzyme family
AXH35_06490	COG3848	Pyruvate phosphate dikinase
AXH35_06505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXH35_06620	COG0395	ABC-type sugar transport system, permease component
AXH35_06645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AXH35_06685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AXH35_06700	COG0252	asparaginase activity
AXH35_06705	COG1113	amino acid transport
AXH35_06715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXH35_06720	COG0047	phosphoribosylformylglycinamidine synthase activity
AXH35_06725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AXH35_06730	COG0450	alkyl hydroperoxide reductase
AXH35_06735	COG3634	alkyl hydroperoxide reductase activity
AXH35_06745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AXH35_06750	COG0151	Belongs to the GarS family
AXH35_06755	COG4423	Transcription factor
AXH35_06760	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
AXH35_06765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AXH35_06780	COG1937	Protein conserved in bacteria
AXH35_06785	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXH35_06800	COG2337	Toxic component of a toxin-antitoxin (TA) module
AXH35_06815	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AXH35_06825	COG3485	protocatechuate 3,4-dioxygenase
AXH35_06830	COG1490	D-aminoacyl-tRNA deacylase activity
AXH35_06860	COG0745	RESPONSE REGULATOR receiver
AXH35_06865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AXH35_06890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AXH35_06895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXH35_06905	COG0254	rRNA binding
AXH35_06910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXH35_06920	COG0523	cobalamin synthesis protein
AXH35_06935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXH35_06940	COG1121	(ABC) transporter
AXH35_06950	COG0803	Belongs to the bacterial solute-binding protein 9 family
AXH35_06955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AXH35_06960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXH35_06965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXH35_06970	COG1120	ATPase activity
AXH35_06990	COG0129	dihydroxy-acid dehydratase activity
AXH35_06995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AXH35_07010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AXH35_07030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AXH35_07040	COG0785	Cytochrome C biogenesis protein
AXH35_07045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXH35_07050	COG0406	alpha-ribazole phosphatase activity
AXH35_07055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AXH35_07055	COG1648	precorrin-2 dehydrogenase activity
AXH35_07060	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AXH35_07085	COG0506	proline dehydrogenase activity
AXH35_07090	COG1082	Xylose isomerase domain protein TIM barrel
AXH35_07105	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AXH35_07110	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AXH35_07130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AXH35_07135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AXH35_07145	COG0181	hydroxymethylbilane synthase activity
AXH35_07155	COG0113	porphobilinogen synthase activity
AXH35_07160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AXH35_07175	COG3842	ATPase activity
AXH35_07185	COG4143	(ABC) transporter
AXH35_07195	COG0457	Tetratricopeptide repeat
AXH35_07195	COG0705	Rhomboid family
AXH35_07250	COG0542	response to heat
AXH35_07260	COG0649	NAD binding
AXH35_07275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AXH35_07280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AXH35_07285	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AXH35_07290	COG0302	gtp cyclohydrolase
AXH35_07305	COG0037	tRNA processing
AXH35_07315	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AXH35_07325	COG3458	cephalosporin-C deacetylase activity
AXH35_07330	COG2062	phosphohistidine phosphatase, SixA
AXH35_07375	COG1522	sequence-specific DNA binding
AXH35_07380	COG1619	proteins homologs of microcin C7 resistance protein MccF
AXH35_07385	COG4172	Belongs to the ABC transporter superfamily
AXH35_07390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AXH35_07395	COG0601	transmembrane transport
AXH35_07425	COG0431	NADPH-dependent FMN reductase
AXH35_07430	COG1231	oxidoreductase activity
AXH35_07470	COG1774	PSP1 C-terminal conserved region
AXH35_07480	COG0470	DNA polymerase III
AXH35_07485	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AXH35_07495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AXH35_07495	COG1754	DNA topoisomerase type I activity
AXH35_07505	COG2890	protein-(glutamine-N5) methyltransferase activity
AXH35_07510	COG1111	helicase
AXH35_07510	COG1205	dead DEAH box helicase
AXH35_07600	COG0494	nUDIX hydrolase
AXH35_07630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXH35_07635	COG1408	metallophosphoesterase
AXH35_07660	COG2040	homocysteine
AXH35_07665	COG1846	Transcriptional regulator
AXH35_07695	COG0601	transmembrane transport
AXH35_07700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AXH35_07705	COG0444	Belongs to the ABC transporter superfamily
AXH35_07710	COG4608	Belongs to the ABC transporter superfamily
AXH35_07725	COG3022	response to hydroperoxide
AXH35_07740	COG1069	ribulokinase activity
AXH35_07745	COG1072	(Pantothenic acid kinase))
AXH35_07765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AXH35_07775	COG0534	Mate efflux family protein
AXH35_07780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXH35_07815	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AXH35_07815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AXH35_07825	COG2197	response regulator
AXH35_07850	COG1793	dna ligase
AXH35_07850	COG3285	dna ligase
AXH35_07855	COG2124	cytochrome p450
AXH35_07860	COG1028	Short-chain dehydrogenase reductase Sdr
AXH35_07870	COG0783	Belongs to the Dps family
AXH35_07875	COG1028	Short-chain dehydrogenase reductase Sdr
AXH35_07890	COG1295	ribonuclease BN
AXH35_07910	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AXH35_07930	COG4572	Cation transport regulator
AXH35_07935	COG0667	Aldo Keto reductase
AXH35_07950	COG3158	transport of potassium into the cell
AXH35_07975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AXH35_08000	COG1518	maintenance of DNA repeat elements
AXH35_08000	COG1468	defense response to virus
AXH35_08025	COG1609	Transcriptional regulator
AXH35_08050	COG1653	transport
AXH35_08055	COG1175	transmembrane transport
AXH35_08060	COG0395	ABC-type sugar transport system, permease component
AXH35_08085	COG3340	Belongs to the peptidase S51 family
AXH35_08095	COG0402	S-adenosylhomocysteine deaminase activity
AXH35_08110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXH35_08120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AXH35_08130	COG0183	Belongs to the thiolase family
AXH35_08145	COG0586	Pfam SNARE associated Golgi protein
AXH35_08155	COG0438	transferase activity, transferring glycosyl groups
AXH35_08165	COG0745	RESPONSE REGULATOR receiver
AXH35_08170	COG1968	undecaprenyl-diphosphatase activity
AXH35_08180	COG0390	transport system, permease component
AXH35_08190	COG1064	alcohol dehydrogenase
AXH35_08200	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AXH35_08205	COG1063	alcohol dehydrogenase
AXH35_08210	COG2376	Dihydroxyacetone kinase
AXH35_08215	COG1946	Acyl-CoA thioesterase
AXH35_08225	COG0673	inositol 2-dehydrogenase activity
AXH35_08230	COG1942	4-Oxalocrotonate Tautomerase
AXH35_08250	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AXH35_08260	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AXH35_08280	COG0433	COG0433 Predicted ATPase
AXH35_08295	COG3263	regulation of cellular component size
AXH35_08300	COG0517	IMP dehydrogenase activity
AXH35_08300	COG1125	glycine betaine transport
AXH35_08310	COG1174	glycine betaine transport
AXH35_08320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AXH35_08365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AXH35_08390	COG2130	NADP-dependent
AXH35_08395	COG0823	Involved in the tonB-independent uptake of proteins
AXH35_08395	COG1506	peptidase
AXH35_08395	COG4946	Tricorn protease homolog
AXH35_08400	COG0584	glycerophosphoryl diester phosphodiesterase
AXH35_08425	COG1316	TRANSCRIPTIONal
AXH35_08430	COG1609	Transcriptional regulator
AXH35_08435	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AXH35_08460	COG3321	synthase
AXH35_08460	COG1028	Short-chain dehydrogenase reductase Sdr
AXH35_08460	COG0604	alcohol dehydrogenase
AXH35_08465	COG0137	argininosuccinate synthase activity
AXH35_08485	COG0561	phosphatase activity
AXH35_08490	COG1609	Transcriptional regulator
AXH35_08505	COG3833	ABC-type maltose transport systems, permease component
AXH35_08525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AXH35_08545	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AXH35_08555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AXH35_08565	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXH35_08570	COG0022	dehydrogenase e1 component
AXH35_08580	COG1233	COG1233 Phytoene dehydrogenase and related
AXH35_08605	COG0477	Major facilitator Superfamily
AXH35_08615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXH35_08620	COG0006	proline dipeptidase activity
AXH35_08660	COG0154	amidase activity
AXH35_08665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXH35_08685	COG1126	abc transporter atp-binding protein
AXH35_08690	COG0765	amino acid transport
AXH35_08695	COG0765	amino acid transport
AXH35_08740	COG1715	Restriction endonuclease
AXH35_08765	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AXH35_08765	COG3976	FMN-binding domain protein
AXH35_08775	COG5002	protein histidine kinase activity
AXH35_08790	COG1621	beta-fructofuranosidase activity
AXH35_08795	COG0477	Major facilitator Superfamily
AXH35_08850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AXH35_08860	COG0366	Alpha amylase catalytic
AXH35_08900	COG1653	transport
AXH35_08905	COG0395	ABC-type sugar transport system, permease component
AXH35_08910	COG1175	transmembrane transport
AXH35_08915	COG1285	pathogenesis
AXH35_08935	COG1940	carbohydrate kinase activity
AXH35_08950	COG0395	ABC-type sugar transport system, permease component
AXH35_08955	COG0366	Alpha amylase catalytic
AXH35_08970	COG1132	(ABC) transporter
AXH35_08975	COG1132	(ABC) transporter
AXH35_08990	COG2423	ornithine cyclodeaminase activity
AXH35_09010	COG0395	ABC-type sugar transport system, permease component
AXH35_09015	COG1175	transmembrane transport
AXH35_09025	COG1609	Transcriptional regulator
AXH35_09040	COG2205	protein histidine kinase activity
AXH35_09050	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AXH35_09085	COG1968	undecaprenyl-diphosphatase activity
AXH35_09095	COG0359	binds to the 23S rRNA
AXH35_09100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AXH35_09110	COG0360	Binds together with S18 to 16S ribosomal RNA
AXH35_09115	COG2837	iron assimilation
AXH35_09125	COG0672	)-iron permease
AXH35_09135	COG1022	Amp-dependent synthetase and ligase
AXH35_09150	COG0300	oxidoreductase activity
AXH35_09195	COG0277	FAD linked oxidase domain protein
AXH35_09200	COG4585	Histidine kinase
AXH35_09205	COG0247	lactate metabolic process
AXH35_09210	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AXH35_09215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AXH35_09220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXH35_09225	COG1846	Transcriptional regulator
AXH35_09235	COG1113	amino acid transport
AXH35_09350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXH35_09360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AXH35_09370	COG1175	transmembrane transport
AXH35_09395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AXH35_09400	COG1733	regulation of RNA biosynthetic process
AXH35_09425	COG2337	Toxic component of a toxin-antitoxin (TA) module
AXH35_09430	COG3609	addiction module antidote protein, CC2985 family
AXH35_09440	COG2146	nitrite reductase [NAD(P)H] activity
AXH35_09445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXH35_09450	COG1716	ATPase activity
AXH35_09450	COG1131	(ABC) transporter
AXH35_09450	COG0842	Transport permease protein
AXH35_09455	COG0515	serine threonine protein kinase
AXH35_09465	COG0205	6-phosphofructokinase activity
AXH35_09470	COG0686	Belongs to the AlaDH PNT family
AXH35_09475	COG2267	carboxylic ester hydrolase activity
AXH35_09520	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AXH35_09530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AXH35_09570	COG0038	chloride channel
AXH35_09580	COG2848	UPF0210 protein
AXH35_09585	COG3830	Belongs to the UPF0237 family
AXH35_09595	COG0114	fumarate hydratase activity
AXH35_09600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AXH35_09635	COG2814	Major facilitator Superfamily
AXH35_09645	COG1349	DNA-binding transcription factor activity
AXH35_09650	COG0540	Belongs to the ATCase OTCase family
AXH35_09665	COG0668	transmembrane transport
AXH35_09675	COG1929	Belongs to the glycerate kinase type-1 family
AXH35_09690	COG1012	belongs to the aldehyde dehydrogenase family
AXH35_09695	COG0385	Bile acid
AXH35_09715	COG0515	serine threonine protein kinase
AXH35_09715	COG2815	serine threonine protein kinase
AXH35_09730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AXH35_09735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AXH35_09740	COG2390	Transcriptional regulator
AXH35_09750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXH35_09765	COG0395	ABC-type sugar transport system, permease component
AXH35_09785	COG1609	Transcriptional regulator
AXH35_09795	COG1733	regulation of RNA biosynthetic process
AXH35_09805	COG0564	pseudouridine synthase activity
AXH35_09855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXH35_09885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AXH35_09930	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AXH35_09945	COG2124	cytochrome p450
AXH35_09955	COG0626	cystathionine gamma-synthase activity
AXH35_09970	COG1660	Displays ATPase and GTPase activities
AXH35_09990	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AXH35_09990	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AXH35_10005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AXH35_10015	COG1082	Xylose isomerase domain protein TIM barrel
AXH35_10020	COG0673	inositol 2-dehydrogenase activity
AXH35_10025	COG1609	Transcriptional regulator
AXH35_10035	COG2855	membrane
AXH35_10040	COG1082	Xylose isomerase domain protein TIM barrel
AXH35_10045	COG0673	inositol 2-dehydrogenase activity
AXH35_10055	COG0673	inositol 2-dehydrogenase activity
AXH35_10060	COG2814	Major facilitator Superfamily
AXH35_10070	COG2814	Major facilitator Superfamily
AXH35_10080	COG1082	Xylose isomerase domain protein TIM barrel
AXH35_10085	COG0673	inositol 2-dehydrogenase activity
AXH35_10090	COG1082	Xylose isomerase domain protein TIM barrel
AXH35_10110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXH35_10115	COG1181	Belongs to the D-alanine--D-alanine ligase family
AXH35_10130	COG1793	dna ligase
AXH35_10130	COG3285	dna ligase
AXH35_10140	COG1192	Involved in chromosome partitioning
AXH35_10150	COG0357	Ribosomal RNA small subunit methyltransferase G
AXH35_10155	COG2076	Multidrug Resistance protein
AXH35_10165	COG0706	membrane insertase activity
AXH35_10175	COG0594	ribonuclease P activity
AXH35_10180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AXH35_10185	COG1136	(ABC) transporter
AXH35_10185	COG0577	efflux transmembrane transporter activity
AXH35_10190	COG0577	efflux transmembrane transporter activity
AXH35_10190	COG1136	(ABC) transporter
AXH35_10195	COG0592	DNA-directed DNA polymerase activity
AXH35_10205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AXH35_10210	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AXH35_10220	COG0187	DNA topoisomerase II activity
AXH35_10225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXH35_10230	COG3266	domain, Protein
AXH35_10240	COG1609	Transcriptional regulator
AXH35_10245	COG1129	ABC transporter
AXH35_10250	COG1172	Belongs to the binding-protein-dependent transport system permease family
AXH35_10255	COG1879	ABC-type sugar transport system periplasmic component
AXH35_10260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXH35_10265	COG1869	D-ribose catabolic process
AXH35_10290	COG1028	Short-chain dehydrogenase reductase Sdr
AXH35_10300	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
AXH35_10305	COG1396	sequence-specific DNA binding
AXH35_10350	COG0039	L-malate dehydrogenase activity
AXH35_10365	COG0281	malic enzyme
AXH35_10370	COG0039	L-malate dehydrogenase activity
AXH35_10375	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AXH35_10385	COG1012	belongs to the aldehyde dehydrogenase family
AXH35_10390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AXH35_10410	COG0531	amino acid
AXH35_10420	COG0235	Class ii aldolase
AXH35_10430	COG1063	alcohol dehydrogenase
AXH35_10435	COG3414	Phosphotransferase system galactitol-specific IIB component
AXH35_10440	COG3775	system Galactitol-specific IIC component
AXH35_10450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AXH35_10455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AXH35_10475	COG1131	(ABC) transporter
AXH35_10485	COG0095	Lipoate-protein ligase
AXH35_10490	COG0148	phosphopyruvate hydratase activity
AXH35_10495	COG0765	amino acid transport
AXH35_10500	COG1126	abc transporter atp-binding protein
AXH35_10505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AXH35_10520	COG1175	transmembrane transport
AXH35_10530	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AXH35_10550	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AXH35_10615	COG1012	belongs to the aldehyde dehydrogenase family
AXH35_10625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AXH35_10655	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AXH35_10680	COG1136	(ABC) transporter
AXH35_10685	COG2197	response regulator
AXH35_10695	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AXH35_10700	COG3657	addiction module killer protein
AXH35_10705	COG1690	Belongs to the RtcB family
AXH35_10710	COG0477	Major facilitator Superfamily
AXH35_10715	COG1132	(ABC) transporter
AXH35_10750	COG2205	protein histidine kinase activity
AXH35_10755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AXH35_10760	COG4585	Histidine kinase
AXH35_10770	COG5002	protein histidine kinase activity
AXH35_10775	COG0745	RESPONSE REGULATOR receiver
AXH35_10785	COG2132	Multicopper oxidase
AXH35_10810	COG0175	sulfate reduction
AXH35_10825	COG0730	response to heat
AXH35_10840	COG1473	amidohydrolase
AXH35_10850	COG0656	L-ascorbic acid biosynthetic process
AXH35_10885	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AXH35_10900	COG2022	thiamine diphosphate biosynthetic process
AXH35_10920	COG1309	transcriptional regulator
AXH35_10925	COG2409	Drug exporters of the RND superfamily
AXH35_10935	COG0438	transferase activity, transferring glycosyl groups
AXH35_10945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXH35_10950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXH35_10960	COG2814	Major facilitator Superfamily
AXH35_10970	COG0477	Major facilitator Superfamily
AXH35_10975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AXH35_10980	COG1914	H( )-stimulated, divalent metal cation uptake system
AXH35_10985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXH35_10985	COG1321	iron dependent repressor
AXH35_11000	COG0281	malic enzyme
AXH35_11020	COG1254	Belongs to the acylphosphatase family
AXH35_11025	COG1042	CoA-binding domain protein
AXH35_11025	COG0045	succinate-CoA ligase (ADP-forming) activity
AXH35_11025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AXH35_11030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AXH35_11040	COG0511	ligase activity, forming carbon-carbon bonds
AXH35_11050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXH35_11060	COG1136	(ABC) transporter
AXH35_11060	COG0577	efflux transmembrane transporter activity
AXH35_11085	COG0205	6-phosphofructokinase activity
AXH35_11125	COG3189	MarR family transcriptional regulator
AXH35_11135	COG2217	Heavy metal translocating P-type atpase
AXH35_11145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXH35_11150	COG0783	Belongs to the Dps family
AXH35_11200	COG1484	DNA-dependent DNA replication
AXH35_11230	COG1484	DNA-dependent DNA replication
AXH35_11250	COG0456	acetyltransferase
AXH35_11260	COG4166	transmembrane transport
AXH35_11275	COG0601	transmembrane transport
AXH35_11305	COG2337	Toxic component of a toxin-antitoxin (TA) module
AXH35_11315	COG1151	hydroxylamine reductase activity
AXH35_11320	COG0543	2 iron, 2 sulfur cluster binding
AXH35_11320	COG0633	Ferredoxin
AXH35_11325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AXH35_11345	COG1140	nitrate reductase beta subunit
AXH35_11365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AXH35_11375	COG0314	molybdopterin synthase activity
AXH35_11385	COG0315	cyclic pyranopterin monophosphate synthase activity
AXH35_11390	COG0521	Mo-molybdopterin cofactor biosynthetic process
AXH35_11390	COG0315	cyclic pyranopterin monophosphate synthase activity
AXH35_11395	COG2364	Membrane
AXH35_11400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AXH35_11400	COG0352	thiamine-phosphate diphosphorylase activity
AXH35_11400	COG0351	phosphomethylpyrimidine kinase
AXH35_11405	COG0352	thiamine-phosphate diphosphorylase activity
AXH35_11410	COG3386	PFAM SMP-30 Gluconolaconase
AXH35_11430	COG1129	ABC transporter
AXH35_11470	COG1012	belongs to the aldehyde dehydrogenase family
AXH35_11480	COG1609	Transcriptional regulator
AXH35_11485	COG1904	glucuronate isomerase
AXH35_11490	COG0246	Mannitol dehydrogenase
AXH35_11495	COG1312	Catalyzes the dehydration of D-mannonate
AXH35_11505	COG0656	L-ascorbic acid biosynthetic process
AXH35_11515	COG4948	Mandelate Racemase Muconate Lactonizing
AXH35_11535	COG1285	pathogenesis
AXH35_11545	COG1609	Transcriptional regulator
AXH35_11550	COG0584	glycerophosphoryl diester phosphodiesterase
AXH35_11555	COG1653	transport
AXH35_11560	COG0395	ABC-type sugar transport system, permease component
AXH35_11610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXH35_11620	COG1482	cell wall glycoprotein biosynthetic process
AXH35_11625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXH35_11630	COG0800	Aldolase
AXH35_11635	COG1414	Transcriptional regulator
AXH35_11640	COG1609	Transcriptional regulator
AXH35_11650	COG2721	sulfolactate sulfo-lyase activity
AXH35_11655	COG1904	glucuronate isomerase
AXH35_11730	COG2211	Major facilitator Superfamily
AXH35_11760	COG5564	TIM-barrel signal transduction protein
AXH35_11770	COG2186	Transcriptional regulator
AXH35_11780	COG0673	inositol 2-dehydrogenase activity
AXH35_11785	COG1609	Transcriptional regulator
AXH35_11790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AXH35_11810	COG1119	ATPase activity
AXH35_11820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AXH35_11830	COG0586	Pfam SNARE associated Golgi protein
AXH35_11835	COG1063	alcohol dehydrogenase
AXH35_11850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AXH35_11880	COG1253	flavin adenine dinucleotide binding
AXH35_11910	COG2072	flavoprotein involved in K transport
AXH35_11995	COG0438	transferase activity, transferring glycosyl groups
AXH35_12000	COG0438	transferase activity, transferring glycosyl groups
AXH35_12040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AXH35_12070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AXH35_12070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AXH35_12070	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AXH35_12075	COG1105	Belongs to the carbohydrate kinase PfkB family
AXH35_12090	COG0765	amino acid transport
AXH35_12095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXH35_12100	COG1126	abc transporter atp-binding protein
AXH35_12105	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AXH35_12115	COG0297	glycogen (starch) synthase activity
AXH35_12155	COG2897	thiosulfate sulfurtransferase activity
AXH35_12170	COG1643	Atp-dependent helicase
AXH35_12185	COG2094	Belongs to the DNA glycosylase MPG family
AXH35_12205	COG1846	Transcriptional regulator
AXH35_12210	COG0386	Belongs to the glutathione peroxidase family
AXH35_12220	COG3118	belongs to the thioredoxin family
AXH35_12225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AXH35_12225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AXH35_12230	COG0305	Participates in initiation and elongation during chromosome replication
AXH35_12235	COG1937	Protein conserved in bacteria
AXH35_12250	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AXH35_12300	COG0489	protein tyrosine kinase activity
AXH35_12325	COG0438	transferase activity, transferring glycosyl groups
AXH35_12355	COG2089	acid synthase
AXH35_12360	COG1083	cytidylyl-transferase
AXH35_12370	COG0167	dihydroorotate dehydrogenase activity
AXH35_12375	COG1013	pyruvate-flavodoxin oxidoreductase activity
AXH35_12375	COG0674	pyruvate-flavodoxin oxidoreductase activity
AXH35_12375	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AXH35_12375	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AXH35_12390	COG2186	Transcriptional regulator
AXH35_12395	COG1620	l-lactate permease
AXH35_12400	COG0247	lactate metabolic process
AXH35_12405	COG1139	Iron-sulfur cluster binding protein
AXH35_12410	COG1556	Lactate utilization protein
AXH35_12420	COG1132	(ABC) transporter
AXH35_12425	COG4988	ABC transporter
AXH35_12430	COG1294	oxidase, subunit
AXH35_12435	COG1271	oxidase subunit
AXH35_12465	COG2814	Major facilitator Superfamily
AXH35_12470	COG1454	alcohol dehydrogenase
AXH35_12480	COG1653	transport
AXH35_12485	COG0395	ABC-type sugar transport system, permease component
AXH35_12495	COG1609	Transcriptional regulator
AXH35_12510	COG1309	transcriptional regulator
AXH35_12515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AXH35_12540	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AXH35_12545	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AXH35_12550	COG2186	Transcriptional regulator
AXH35_12570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AXH35_12575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AXH35_12580	COG1301	dicarboxylic acid transport
AXH35_12585	COG1953	Uracil, thiamine, allantoin
AXH35_12595	COG0393	Putative heavy-metal-binding
AXH35_12600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AXH35_12620	COG0515	serine threonine protein kinase
AXH35_12625	COG0768	penicillin binding
AXH35_12640	COG1716	ATPase activity
AXH35_12645	COG1716	ATPase activity
AXH35_12655	COG1088	dTDP-glucose 4,6-dehydratase activity
AXH35_12660	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AXH35_12675	COG0604	alcohol dehydrogenase
AXH35_12695	COG1316	TRANSCRIPTIONal
AXH35_12705	COG0489	protein tyrosine kinase activity
AXH35_12710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AXH35_12720	COG0438	transferase activity, transferring glycosyl groups
AXH35_12730	COG1484	DNA-dependent DNA replication
AXH35_12780	COG0477	Major facilitator Superfamily
AXH35_12785	COG1695	Transcriptional regulator
AXH35_12790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AXH35_12800	COG1113	amino acid transport
AXH35_12805	COG1309	transcriptional regulator
AXH35_12810	COG1131	(ABC) transporter
AXH35_12855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AXH35_12860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AXH35_12885	COG0577	efflux transmembrane transporter activity
AXH35_12885	COG1136	(ABC) transporter
AXH35_12895	COG0561	phosphatase activity
AXH35_12900	COG0561	phosphatase activity
AXH35_12905	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AXH35_12940	COG0861	Integral membrane protein TerC family
AXH35_12945	COG2814	Major facilitator Superfamily
AXH35_12950	COG0583	DNA-binding transcription factor activity
AXH35_12970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AXH35_12975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AXH35_12985	COG0667	Aldo Keto reductase
AXH35_13005	COG1881	PFAM PEBP family protein
AXH35_13015	COG4581	dead DEAH box helicase
AXH35_13025	COG0166	Belongs to the GPI family
AXH35_13040	COG2814	Major facilitator Superfamily
AXH35_13045	COG0656	L-ascorbic acid biosynthetic process
AXH35_13050	COG0018	arginyl-trna synthetase
AXH35_13070	COG2814	Major facilitator Superfamily
AXH35_13085	COG1012	belongs to the aldehyde dehydrogenase family
AXH35_13095	COG1070	Carbohydrate kinase
AXH35_13100	COG4952	isomerase
AXH35_13105	COG2814	Major facilitator Superfamily
AXH35_13110	COG3254	rhamnose metabolic process
AXH35_13115	COG1609	Transcriptional regulator
AXH35_13155	COG1609	Transcriptional regulator
AXH35_13165	COG0673	inositol 2-dehydrogenase activity
AXH35_13185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AXH35_13195	COG1027	Aspartate ammonia-lyase
AXH35_13240	COG0154	amidase activity
AXH35_13245	COG4608	Belongs to the ABC transporter superfamily
AXH35_13270	COG1309	transcriptional regulator
AXH35_13285	COG0676	glucose-6-phosphate 1-epimerase activity
AXH35_13290	COG3830	Belongs to the UPF0237 family
AXH35_13290	COG0560	Phosphoserine phosphatase
AXH35_13295	COG2813	Specifically methylates the guanine in position
AXH35_13300	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AXH35_13305	COG0574	Belongs to the PEP-utilizing enzyme family
AXH35_13305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXH35_13320	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AXH35_13325	COG2205	protein histidine kinase activity
AXH35_13330	COG0745	RESPONSE REGULATOR receiver
AXH35_13350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AXH35_13355	COG0484	heat shock protein binding
AXH35_13360	COG0789	Transcriptional regulator
AXH35_13365	COG1063	alcohol dehydrogenase
AXH35_13370	COG3527	Alpha-acetolactate decarboxylase
AXH35_13375	COG2985	domain, Protein
AXH35_13375	COG0569	domain protein
AXH35_13380	COG1113	amino acid transport
AXH35_13390	COG1136	(ABC) transporter
AXH35_13390	COG0577	efflux transmembrane transporter activity
AXH35_13395	COG4591	ABC-type transport system involved in lipoprotein release permease component
AXH35_13395	COG1136	(ABC) transporter
AXH35_13405	COG2197	response regulator
AXH35_13410	COG4585	Histidine kinase
AXH35_13425	COG3588	fructose-bisphosphate aldolase
AXH35_13430	COG1609	Transcriptional regulator
AXH35_13440	COG2211	Major facilitator Superfamily
AXH35_13440	COG2190	(PTS) system
AXH35_13455	COG0395	ABC-type sugar transport system, permease component
AXH35_13465	COG0542	response to heat
AXH35_13470	COG0395	ABC-type sugar transport system, permease component
AXH35_13475	COG1175	transmembrane transport
AXH35_13485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXH35_13495	COG1486	melibiose metabolic process
AXH35_13510	COG1511	domain protein
AXH35_13520	COG1309	transcriptional regulator
AXH35_13525	COG0702	epimerase
AXH35_13540	COG0395	ABC-type sugar transport system, permease component
AXH35_13545	COG1175	transmembrane transport
AXH35_13550	COG2182	Extracellular solute-binding protein
AXH35_13555	COG1609	Transcriptional regulator
AXH35_13560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AXH35_13570	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AXH35_13595	COG3012	SEC-C Motif Domain Protein
AXH35_13600	COG0517	IMP dehydrogenase activity
AXH35_13600	COG4175	Glycine betaine
AXH35_13605	COG4176	ABC-type proline glycine betaine transport system permease component
AXH35_13625	COG1174	glycine betaine transport
AXH35_13635	COG1174	glycine betaine transport
AXH35_13650	COG0436	Aminotransferase
AXH35_13675	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AXH35_13675	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AXH35_13695	COG0438	transferase activity, transferring glycosyl groups
AXH35_13725	COG2244	polysaccharide biosynthetic process
AXH35_13730	COG0489	protein tyrosine kinase activity
AXH35_13750	COG0586	Pfam SNARE associated Golgi protein
AXH35_13765	COG0191	fructose-bisphosphate aldolase activity
AXH35_13795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXH35_13800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXH35_13805	COG0588	phosphoglycerate mutase activity
AXH35_13810	COG0704	Plays a role in the regulation of phosphate uptake
AXH35_13815	COG5002	protein histidine kinase activity
AXH35_13830	COG1329	Transcriptional regulator
AXH35_13835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXH35_13845	COG3775	system Galactitol-specific IIC component
AXH35_13855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AXH35_13870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AXH35_13875	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AXH35_13895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AXH35_13900	COG2814	Major facilitator Superfamily
AXH35_13910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXH35_13915	COG0215	cysteine-tRNA ligase activity
AXH35_13930	COG0626	cystathionine gamma-synthase activity
AXH35_13980	COG1484	DNA-dependent DNA replication
AXH35_13990	COG3842	ATPase activity
AXH35_14005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AXH35_14015	COG1760	l-serine dehydratase
AXH35_14020	COG1940	carbohydrate kinase activity
AXH35_14025	COG1653	transport
AXH35_14035	COG0395	ABC-type sugar transport system, permease component
AXH35_14040	COG1063	alcohol dehydrogenase
AXH35_14045	COG0156	8-amino-7-oxononanoate synthase activity
AXH35_14055	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AXH35_14060	COG1131	(ABC) transporter
AXH35_14070	COG4585	Histidine kinase
AXH35_14075	COG2197	response regulator
AXH35_14085	COG0406	alpha-ribazole phosphatase activity
AXH35_14100	COG1131	(ABC) transporter
AXH35_14105	COG4585	Histidine kinase
AXH35_14115	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AXH35_14120	COG1492	cobalamin metabolic process
AXH35_14140	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AXH35_14140	COG1648	precorrin-2 dehydrogenase activity
AXH35_14155	COG0310	cobalt ion transport
AXH35_14180	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AXH35_14185	COG1797	cobyrinic acid a,c-diamide synthase activity
AXH35_14190	COG1648	precorrin-2 dehydrogenase activity
AXH35_14190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AXH35_14200	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AXH35_14230	COG1854	S-ribosylhomocysteine lyase activity
AXH35_14235	COG1482	cell wall glycoprotein biosynthetic process
AXH35_14245	COG0459	protein refolding
AXH35_14365	COG0740	serine-type endopeptidase activity
AXH35_14595	COG0363	glucosamine-6-phosphate deaminase activity
AXH35_14600	COG1278	Cold shock
AXH35_14615	COG2252	PERMEase
AXH35_14640	COG1321	iron dependent repressor
AXH35_14645	COG2226	methyltransferase
AXH35_14650	COG3118	belongs to the thioredoxin family
AXH35_14655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AXH35_14660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXH35_14670	COG3718	enzyme involved in inositol metabolism
AXH35_14675	COG3962	Belongs to the TPP enzyme family
AXH35_14690	COG0673	inositol 2-dehydrogenase activity
AXH35_14695	COG2814	Major facilitator Superfamily
AXH35_14700	COG0673	inositol 2-dehydrogenase activity
AXH35_14720	COG1970	mechanosensitive ion channel activity
AXH35_14735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AXH35_14780	COG2409	Drug exporters of the RND superfamily
AXH35_14850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AXH35_14870	COG1053	succinate dehydrogenase
AXH35_14875	COG1309	transcriptional regulator
AXH35_14900	COG0789	Transcriptional regulator
AXH35_14910	COG0693	protein deglycase activity
AXH35_14970	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AXH35_14975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AXH35_14985	COG2233	PERMEase
AXH35_15000	COG0084	hydrolase, TatD family'
AXH35_15005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AXH35_15010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AXH35_15015	COG1846	Transcriptional regulator
AXH35_15020	COG1309	transcriptional regulator
AXH35_15030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AXH35_15035	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AXH35_15040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AXH35_15045	COG0193	aminoacyl-tRNA hydrolase activity
AXH35_15065	COG0148	phosphopyruvate hydratase activity
AXH35_15095	COG2837	iron assimilation
AXH35_15100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXH35_15150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AXH35_15155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AXH35_15160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AXH35_15165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXH35_15175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AXH35_15180	COG0072	phenylalanine-tRNA ligase activity
AXH35_15180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXH35_15185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AXH35_15200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AXH35_15235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXH35_15240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AXH35_15255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AXH35_15270	COG1331	Highly conserved protein containing a thioredoxin domain
AXH35_15280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXH35_15290	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AXH35_15300	COG1722	exodeoxyribonuclease VII activity
AXH35_15305	COG1570	exodeoxyribonuclease VII activity
AXH35_15310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AXH35_15315	COG1322	Protein conserved in bacteria
AXH35_15320	COG1362	aminopeptidase activity
AXH35_15325	COG1136	(ABC) transporter
AXH35_15325	COG0577	efflux transmembrane transporter activity
AXH35_15330	COG0577	efflux transmembrane transporter activity
AXH35_15330	COG1136	(ABC) transporter
AXH35_15345	COG0012	GTP binding
AXH35_15430	COG1397	ADP-ribosylglycohydrolase
AXH35_15445	COG1132	(ABC) transporter
AXH35_15450	COG0406	alpha-ribazole phosphatase activity
AXH35_15470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AXH35_15475	COG1335	isochorismatase
AXH35_15500	COG1028	Short-chain dehydrogenase reductase Sdr
AXH35_15500	COG0604	alcohol dehydrogenase
AXH35_15500	COG3321	synthase
AXH35_15505	COG0477	Major facilitator Superfamily
AXH35_15510	COG0477	Major facilitator Superfamily
AXH35_15535	COG2716	regulation of RNA biosynthetic process
AXH35_15540	COG2133	pyrroloquinoline quinone binding
AXH35_15555	COG0833	amino acid
AXH35_15590	COG2501	S4 domain
AXH35_15605	COG1126	abc transporter atp-binding protein
AXH35_15610	COG0765	amino acid transport
AXH35_15640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXH35_15645	COG1121	(ABC) transporter
AXH35_15665	COG1012	belongs to the aldehyde dehydrogenase family
AXH35_15670	COG1063	alcohol dehydrogenase
AXH35_15675	COG2376	Dihydroxyacetone kinase
AXH35_15680	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AXH35_15685	COG1349	DNA-binding transcription factor activity
AXH35_15690	COG0698	ribose 5-phosphate isomerase
AXH35_15700	COG0647	UMP catabolic process
AXH35_15710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AXH35_15745	COG2814	Major facilitator Superfamily
AXH35_15750	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AXH35_15755	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AXH35_15760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AXH35_15765	COG2720	vancomycin resistance protein
AXH35_15790	COG2171	N-acyltransferase activity
AXH35_15800	COG1611	Belongs to the LOG family
AXH35_15810	COG0297	glycogen (starch) synthase activity
AXH35_15815	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AXH35_15840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXH35_15845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AXH35_15880	COG0006	proline dipeptidase activity
AXH35_15895	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AXH35_15900	COG0531	amino acid
AXH35_15920	COG0598	Magnesium transport protein CorA
AXH35_15945	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AXH35_15955	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AXH35_15970	COG3093	addiction module antidote protein HigA
AXH35_15980	COG0174	glutamine synthetase
AXH35_16005	COG2239	Acts as a magnesium transporter
AXH35_16010	COG0488	(ABC) transporter
AXH35_16020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AXH35_16035	COG0321	lipoyl(octanoyl) transferase activity
AXH35_16040	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXH35_16080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AXH35_16085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AXH35_16105	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AXH35_16110	COG0723	plastoquinol--plastocyanin reductase activity
AXH35_16115	COG2010	Cytochrome c
AXH35_16120	COG1845	cytochrome c oxidase, subunit III
AXH35_16130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AXH35_16175	COG1940	carbohydrate kinase activity
AXH35_16195	COG2197	response regulator
AXH35_16200	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AXH35_16215	COG2815	serine threonine protein kinase
AXH35_16215	COG0515	serine threonine protein kinase
AXH35_16225	COG0352	thiamine-phosphate diphosphorylase activity
AXH35_16235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AXH35_16240	COG0210	DNA helicase
AXH35_16260	COG1116	anion transmembrane transporter activity
AXH35_16260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AXH35_16265	COG0596	Alpha beta hydrolase
AXH35_16275	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AXH35_16285	COG3265	gluconokinase activity
AXH35_16305	COG1131	(ABC) transporter
AXH35_16310	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXH35_16310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXH35_16315	COG0509	glycine decarboxylation via glycine cleavage system
AXH35_16320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AXH35_16340	COG0714	Associated with various cellular activities
AXH35_16345	COG2001	Belongs to the MraZ family
AXH35_16350	COG0275	rRNA processing
AXH35_16360	COG0768	penicillin binding
AXH35_16370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AXH35_16375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXH35_16380	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AXH35_16385	COG0772	Belongs to the SEDS family
AXH35_16390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AXH35_16395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXH35_16405	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AXH35_16415	COG1799	cell septum assembly
AXH35_16430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AXH35_16445	COG0469	pyruvate kinase activity
AXH35_16460	COG2050	protein possibly involved in aromatic compounds catabolism
AXH35_16485	COG0539	negative regulation of cytoplasmic translation
AXH35_16490	COG0237	dephospho-CoA kinase activity
AXH35_16505	COG0556	nucleotide-excision repair
AXH35_16520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXH35_16540	COG0322	excinuclease ABC activity
AXH35_16545	COG1660	Displays ATPase and GTPase activities
AXH35_16550	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AXH35_16555	COG1481	regulation of sporulation
AXH35_16560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AXH35_16565	COG0126	phosphoglycerate kinase activity
AXH35_16570	COG0149	triose-phosphate isomerase activity
AXH35_16575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AXH35_16585	COG0285	dihydrofolate synthase activity
AXH35_16595	COG0105	UTP biosynthetic process
AXH35_16605	COG1472	Belongs to the glycosyl hydrolase 3 family
AXH35_16615	COG1530	ribonuclease E activity
AXH35_16620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AXH35_16625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AXH35_16635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AXH35_16640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AXH35_16645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AXH35_16650	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AXH35_16765	COG0739	heme binding
AXH35_16765	COG1196	nuclear chromosome segregation
AXH35_16765	COG0741	lytic transglycosylase activity
AXH35_16830	COG0732	type I restriction modification DNA specificity domain
AXH35_16855	COG4974	Belongs to the 'phage' integrase family
AXH35_16875	COG1609	Transcriptional regulator
AXH35_16880	COG2801	Transposase and inactivated derivatives
AXH35_16910	COG2801	Transposase and inactivated derivatives
AXH35_16930	COG1609	Transcriptional regulator
AXH35_16935	COG0445	tRNA wobble uridine modification
AXH35_16940	COG2271	Major facilitator Superfamily
AXH35_16950	COG0667	Aldo Keto reductase
AXH35_16960	COG2217	Heavy metal translocating P-type atpase
AXH35_16975	COG0693	protein deglycase activity