locus-tag	class	description
ASQ49_00070	COG0739	heme binding
ASQ49_00070	COG0741	lytic transglycosylase activity
ASQ49_00070	COG1196	nuclear chromosome segregation
ASQ49_00170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ASQ49_00185	COG1970	mechanosensitive ion channel activity
ASQ49_00205	COG0673	inositol 2-dehydrogenase activity
ASQ49_00210	COG2814	Major facilitator Superfamily
ASQ49_00215	COG0673	inositol 2-dehydrogenase activity
ASQ49_00230	COG3962	Belongs to the TPP enzyme family
ASQ49_00235	COG3718	enzyme involved in inositol metabolism
ASQ49_00245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASQ49_00250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ASQ49_00255	COG3118	belongs to the thioredoxin family
ASQ49_00260	COG2226	methyltransferase
ASQ49_00265	COG1321	iron dependent repressor
ASQ49_00290	COG2252	PERMEase
ASQ49_00305	COG1278	Cold shock
ASQ49_00310	COG0363	glucosamine-6-phosphate deaminase activity
ASQ49_00355	COG0459	protein refolding
ASQ49_00365	COG1482	cell wall glycoprotein biosynthetic process
ASQ49_00370	COG1854	S-ribosylhomocysteine lyase activity
ASQ49_00400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ASQ49_00410	COG1648	precorrin-2 dehydrogenase activity
ASQ49_00410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASQ49_00415	COG1797	cobyrinic acid a,c-diamide synthase activity
ASQ49_00420	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ASQ49_00445	COG0310	cobalt ion transport
ASQ49_00460	COG1648	precorrin-2 dehydrogenase activity
ASQ49_00460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASQ49_00480	COG1492	cobalamin metabolic process
ASQ49_00495	COG4585	Histidine kinase
ASQ49_00515	COG0406	alpha-ribazole phosphatase activity
ASQ49_00525	COG2197	response regulator
ASQ49_00530	COG4585	Histidine kinase
ASQ49_00540	COG1131	(ABC) transporter
ASQ49_00545	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ASQ49_00555	COG0156	8-amino-7-oxononanoate synthase activity
ASQ49_00560	COG1063	alcohol dehydrogenase
ASQ49_00565	COG0395	ABC-type sugar transport system, permease component
ASQ49_00570	COG1175	transmembrane transport
ASQ49_00575	COG1653	transport
ASQ49_00580	COG1940	carbohydrate kinase activity
ASQ49_00585	COG1760	l-serine dehydratase
ASQ49_00595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASQ49_00610	COG3842	ATPase activity
ASQ49_00665	COG0626	cystathionine gamma-synthase activity
ASQ49_00680	COG0215	cysteine-tRNA ligase activity
ASQ49_00685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASQ49_00695	COG2814	Major facilitator Superfamily
ASQ49_00700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASQ49_00720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ASQ49_00725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ASQ49_00740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ASQ49_00750	COG3775	system Galactitol-specific IIC component
ASQ49_00760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASQ49_00765	COG1329	Transcriptional regulator
ASQ49_00780	COG5002	protein histidine kinase activity
ASQ49_00785	COG0704	Plays a role in the regulation of phosphate uptake
ASQ49_00790	COG0588	phosphoglycerate mutase activity
ASQ49_00795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASQ49_00800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASQ49_00830	COG0191	fructose-bisphosphate aldolase activity
ASQ49_00845	COG0586	Pfam SNARE associated Golgi protein
ASQ49_00865	COG0489	protein tyrosine kinase activity
ASQ49_00870	COG2244	polysaccharide biosynthetic process
ASQ49_00880	COG0438	transferase activity, transferring glycosyl groups
ASQ49_00890	COG0438	transferase activity, transferring glycosyl groups
ASQ49_00910	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ASQ49_00910	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ASQ49_00915	COG1704	LemA family
ASQ49_00935	COG0436	Aminotransferase
ASQ49_00950	COG1174	glycine betaine transport
ASQ49_00960	COG1174	glycine betaine transport
ASQ49_00975	COG1131	(ABC) transporter
ASQ49_00980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_00995	COG4176	ABC-type proline glycine betaine transport system permease component
ASQ49_01000	COG0517	IMP dehydrogenase activity
ASQ49_01000	COG4175	Glycine betaine
ASQ49_01005	COG3012	SEC-C Motif Domain Protein
ASQ49_01045	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ASQ49_01055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ASQ49_01065	COG0702	epimerase
ASQ49_01070	COG1309	transcriptional regulator
ASQ49_01080	COG1511	domain protein
ASQ49_01095	COG1486	melibiose metabolic process
ASQ49_01105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASQ49_01115	COG1175	transmembrane transport
ASQ49_01120	COG0395	ABC-type sugar transport system, permease component
ASQ49_01125	COG0542	response to heat
ASQ49_01135	COG0395	ABC-type sugar transport system, permease component
ASQ49_01150	COG3588	fructose-bisphosphate aldolase
ASQ49_01175	COG4585	Histidine kinase
ASQ49_01180	COG2197	response regulator
ASQ49_01190	COG0577	efflux transmembrane transporter activity
ASQ49_01190	COG1136	(ABC) transporter
ASQ49_01195	COG0577	efflux transmembrane transporter activity
ASQ49_01195	COG1136	(ABC) transporter
ASQ49_01205	COG1113	amino acid transport
ASQ49_01210	COG0569	domain protein
ASQ49_01210	COG2985	domain, Protein
ASQ49_01215	COG3527	Alpha-acetolactate decarboxylase
ASQ49_01220	COG1063	alcohol dehydrogenase
ASQ49_01225	COG0789	Transcriptional regulator
ASQ49_01230	COG0484	heat shock protein binding
ASQ49_01235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ASQ49_01255	COG0745	RESPONSE REGULATOR receiver
ASQ49_01260	COG2205	protein histidine kinase activity
ASQ49_01265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ASQ49_01280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASQ49_01280	COG0574	Belongs to the PEP-utilizing enzyme family
ASQ49_01285	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ASQ49_01290	COG2813	Specifically methylates the guanine in position
ASQ49_01295	COG3830	Belongs to the UPF0237 family
ASQ49_01295	COG0560	Phosphoserine phosphatase
ASQ49_01315	COG1309	transcriptional regulator
ASQ49_01320	COG1131	(ABC) transporter
ASQ49_01340	COG4608	Belongs to the ABC transporter superfamily
ASQ49_01345	COG0154	amidase activity
ASQ49_01355	COG1309	transcriptional regulator
ASQ49_01360	COG0477	Major facilitator Superfamily
ASQ49_01400	COG1027	Aspartate ammonia-lyase
ASQ49_01410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASQ49_01425	COG1609	Transcriptional regulator
ASQ49_01465	COG1609	Transcriptional regulator
ASQ49_01470	COG3254	rhamnose metabolic process
ASQ49_01480	COG4952	isomerase
ASQ49_01485	COG1070	Carbohydrate kinase
ASQ49_01495	COG1012	belongs to the aldehyde dehydrogenase family
ASQ49_01510	COG2814	Major facilitator Superfamily
ASQ49_01530	COG0018	arginyl-trna synthetase
ASQ49_01535	COG0656	L-ascorbic acid biosynthetic process
ASQ49_01540	COG2814	Major facilitator Superfamily
ASQ49_01555	COG0166	Belongs to the GPI family
ASQ49_01565	COG4581	dead DEAH box helicase
ASQ49_01575	COG1881	PFAM PEBP family protein
ASQ49_01595	COG0667	Aldo Keto reductase
ASQ49_01605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASQ49_01610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASQ49_01630	COG0583	DNA-binding transcription factor activity
ASQ49_01635	COG2814	Major facilitator Superfamily
ASQ49_01640	COG0861	Integral membrane protein TerC family
ASQ49_01650	COG2801	Transposase and inactivated derivatives
ASQ49_01680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ASQ49_01685	COG0561	phosphatase activity
ASQ49_01690	COG0561	phosphatase activity
ASQ49_01715	COG1136	(ABC) transporter
ASQ49_01715	COG0577	efflux transmembrane transporter activity
ASQ49_01740	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ASQ49_01745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ASQ49_01790	COG1131	(ABC) transporter
ASQ49_01795	COG1309	transcriptional regulator
ASQ49_01800	COG1113	amino acid transport
ASQ49_01815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ASQ49_01820	COG1695	Transcriptional regulator
ASQ49_01825	COG0477	Major facilitator Superfamily
ASQ49_01890	COG0438	transferase activity, transferring glycosyl groups
ASQ49_01905	COG0489	protein tyrosine kinase activity
ASQ49_01915	COG1316	TRANSCRIPTIONal
ASQ49_01935	COG0604	alcohol dehydrogenase
ASQ49_01950	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ASQ49_01955	COG1088	dTDP-glucose 4,6-dehydratase activity
ASQ49_01965	COG1716	ATPase activity
ASQ49_01970	COG1716	ATPase activity
ASQ49_01985	COG0768	penicillin binding
ASQ49_01990	COG0515	serine threonine protein kinase
ASQ49_02010	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ASQ49_02015	COG0393	Putative heavy-metal-binding
ASQ49_02025	COG1953	Uracil, thiamine, allantoin
ASQ49_02030	COG1301	dicarboxylic acid transport
ASQ49_02035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASQ49_02040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ASQ49_02060	COG2186	Transcriptional regulator
ASQ49_02065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ASQ49_02070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ASQ49_02095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASQ49_02100	COG1309	transcriptional regulator
ASQ49_02115	COG1609	Transcriptional regulator
ASQ49_02125	COG0395	ABC-type sugar transport system, permease component
ASQ49_02140	COG1454	alcohol dehydrogenase
ASQ49_02145	COG0477	Major facilitator Superfamily
ASQ49_02170	COG2197	response regulator
ASQ49_02180	COG1271	oxidase subunit
ASQ49_02185	COG1294	oxidase, subunit
ASQ49_02190	COG4988	ABC transporter
ASQ49_02195	COG1132	(ABC) transporter
ASQ49_02200	COG1556	Lactate utilization protein
ASQ49_02205	COG1139	Iron-sulfur cluster binding protein
ASQ49_02210	COG0247	lactate metabolic process
ASQ49_02215	COG1620	l-lactate permease
ASQ49_02220	COG2186	Transcriptional regulator
ASQ49_02235	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASQ49_02235	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASQ49_02235	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASQ49_02235	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ASQ49_02240	COG0167	dihydroorotate dehydrogenase activity
ASQ49_02250	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASQ49_02265	COG1937	Protein conserved in bacteria
ASQ49_02270	COG0305	Participates in initiation and elongation during chromosome replication
ASQ49_02275	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASQ49_02275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASQ49_02280	COG3118	belongs to the thioredoxin family
ASQ49_02290	COG0386	Belongs to the glutathione peroxidase family
ASQ49_02295	COG1846	Transcriptional regulator
ASQ49_02315	COG2094	Belongs to the DNA glycosylase MPG family
ASQ49_02330	COG1643	Atp-dependent helicase
ASQ49_02345	COG2897	thiosulfate sulfurtransferase activity
ASQ49_02420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ASQ49_02425	COG1126	abc transporter atp-binding protein
ASQ49_02430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASQ49_02435	COG0765	amino acid transport
ASQ49_02440	COG0765	amino acid transport
ASQ49_02450	COG1105	Belongs to the carbohydrate kinase PfkB family
ASQ49_02455	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ASQ49_02455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASQ49_02455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASQ49_02485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASQ49_02525	COG0438	transferase activity, transferring glycosyl groups
ASQ49_02545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASQ49_02610	COG2801	Transposase and inactivated derivatives
ASQ49_02725	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ASQ49_02745	COG3620	sequence-specific DNA binding
ASQ49_02835	COG2072	flavoprotein involved in K transport
ASQ49_02870	COG1253	flavin adenine dinucleotide binding
ASQ49_02905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ASQ49_02920	COG1063	alcohol dehydrogenase
ASQ49_02925	COG0586	Pfam SNARE associated Golgi protein
ASQ49_02935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASQ49_02945	COG1119	ATPase activity
ASQ49_02960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ASQ49_02965	COG1414	Transcriptional regulator
ASQ49_02970	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ASQ49_02975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASQ49_02980	COG0402	S-adenosylhomocysteine deaminase activity
ASQ49_02985	COG1228	amidohydrolase
ASQ49_03005	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ASQ49_03010	COG1609	Transcriptional regulator
ASQ49_03025	COG2186	Transcriptional regulator
ASQ49_03035	COG5564	TIM-barrel signal transduction protein
ASQ49_03065	COG2211	Major facilitator Superfamily
ASQ49_03110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ASQ49_03150	COG2826	transposase and inactivated derivatives, IS30 family
ASQ49_03155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASQ49_03160	COG2801	Transposase and inactivated derivatives
ASQ49_03190	COG1904	glucuronate isomerase
ASQ49_03195	COG2721	sulfolactate sulfo-lyase activity
ASQ49_03205	COG1609	Transcriptional regulator
ASQ49_03210	COG1414	Transcriptional regulator
ASQ49_03215	COG0800	Aldolase
ASQ49_03225	COG1482	cell wall glycoprotein biosynthetic process
ASQ49_03235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASQ49_03255	COG3119	arylsulfatase activity
ASQ49_03260	COG1940	carbohydrate kinase activity
ASQ49_03265	COG0477	Major facilitator Superfamily
ASQ49_03270	COG3119	arylsulfatase activity
ASQ49_03275	COG2149	membrane
ASQ49_03285	COG0641	radical SAM
ASQ49_03300	COG1070	Carbohydrate kinase
ASQ49_03315	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ASQ49_03315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ASQ49_03360	COG0519	Catalyzes the synthesis of GMP from XMP
ASQ49_03360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASQ49_03395	COG0210	DNA helicase
ASQ49_03445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ASQ49_03500	COG1175	transmembrane transport
ASQ49_03505	COG0395	ABC-type sugar transport system, permease component
ASQ49_03510	COG1653	transport
ASQ49_03515	COG0584	glycerophosphoryl diester phosphodiesterase
ASQ49_03520	COG1609	Transcriptional regulator
ASQ49_03530	COG1285	pathogenesis
ASQ49_03550	COG4948	Mandelate Racemase Muconate Lactonizing
ASQ49_03560	COG0656	L-ascorbic acid biosynthetic process
ASQ49_03570	COG1312	Catalyzes the dehydration of D-mannonate
ASQ49_03575	COG0246	Mannitol dehydrogenase
ASQ49_03580	COG1904	glucuronate isomerase
ASQ49_03585	COG1609	Transcriptional regulator
ASQ49_03595	COG1012	belongs to the aldehyde dehydrogenase family
ASQ49_03625	COG1609	Transcriptional regulator
ASQ49_03635	COG1129	ABC transporter
ASQ49_03640	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASQ49_03645	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASQ49_03660	COG3386	PFAM SMP-30 Gluconolaconase
ASQ49_03665	COG0352	thiamine-phosphate diphosphorylase activity
ASQ49_03670	COG0351	phosphomethylpyrimidine kinase
ASQ49_03670	COG0352	thiamine-phosphate diphosphorylase activity
ASQ49_03670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ASQ49_03680	COG0315	cyclic pyranopterin monophosphate synthase activity
ASQ49_03680	COG0521	Mo-molybdopterin cofactor biosynthetic process
ASQ49_03685	COG0315	cyclic pyranopterin monophosphate synthase activity
ASQ49_03695	COG0314	molybdopterin synthase activity
ASQ49_03705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASQ49_03725	COG1140	nitrate reductase beta subunit
ASQ49_03745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ASQ49_03750	COG0543	2 iron, 2 sulfur cluster binding
ASQ49_03750	COG0633	Ferredoxin
ASQ49_03755	COG1151	hydroxylamine reductase activity
ASQ49_03765	COG2337	Toxic component of a toxin-antitoxin (TA) module
ASQ49_03795	COG0601	transmembrane transport
ASQ49_03810	COG4166	transmembrane transport
ASQ49_03815	COG0435	Glutathione S-transferase
ASQ49_03830	COG0456	acetyltransferase
ASQ49_03865	COG0783	Belongs to the Dps family
ASQ49_03870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ASQ49_03880	COG2217	Heavy metal translocating P-type atpase
ASQ49_03890	COG3189	MarR family transcriptional regulator
ASQ49_03930	COG0205	6-phosphofructokinase activity
ASQ49_03955	COG1136	(ABC) transporter
ASQ49_03955	COG0577	efflux transmembrane transporter activity
ASQ49_03965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASQ49_03975	COG5016	pyruvate
ASQ49_03975	COG0511	ligase activity, forming carbon-carbon bonds
ASQ49_03985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASQ49_03990	COG0045	succinate-CoA ligase (ADP-forming) activity
ASQ49_03995	COG1254	Belongs to the acylphosphatase family
ASQ49_04015	COG0281	malic enzyme
ASQ49_04030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASQ49_04030	COG1321	iron dependent repressor
ASQ49_04035	COG1914	H( )-stimulated, divalent metal cation uptake system
ASQ49_04040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASQ49_04045	COG0477	Major facilitator Superfamily
ASQ49_04055	COG2814	Major facilitator Superfamily
ASQ49_04065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASQ49_04070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASQ49_04080	COG0438	transferase activity, transferring glycosyl groups
ASQ49_04090	COG2801	Transposase and inactivated derivatives
ASQ49_04100	COG2409	Drug exporters of the RND superfamily
ASQ49_04105	COG1309	transcriptional regulator
ASQ49_04125	COG2022	thiamine diphosphate biosynthetic process
ASQ49_04135	COG0596	Alpha beta hydrolase
ASQ49_04135	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASQ49_04140	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASQ49_04175	COG0656	L-ascorbic acid biosynthetic process
ASQ49_04185	COG1473	amidohydrolase
ASQ49_04200	COG0730	response to heat
ASQ49_04215	COG0175	sulfate reduction
ASQ49_04245	COG2132	Multicopper oxidase
ASQ49_04255	COG0745	RESPONSE REGULATOR receiver
ASQ49_04260	COG5002	protein histidine kinase activity
ASQ49_04270	COG4585	Histidine kinase
ASQ49_04275	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ASQ49_04280	COG2205	protein histidine kinase activity
ASQ49_04290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ASQ49_04320	COG1132	(ABC) transporter
ASQ49_04325	COG0477	Major facilitator Superfamily
ASQ49_04330	COG1690	Belongs to the RtcB family
ASQ49_04335	COG3657	addiction module killer protein
ASQ49_04340	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ASQ49_04350	COG2197	response regulator
ASQ49_04355	COG1136	(ABC) transporter
ASQ49_04380	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ASQ49_04410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ASQ49_04420	COG1012	belongs to the aldehyde dehydrogenase family
ASQ49_04490	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ASQ49_04510	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ASQ49_04520	COG1175	transmembrane transport
ASQ49_04535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASQ49_04540	COG1126	abc transporter atp-binding protein
ASQ49_04545	COG0765	amino acid transport
ASQ49_04555	COG0095	Lipoate-protein ligase
ASQ49_04565	COG1131	(ABC) transporter
ASQ49_04585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ASQ49_04590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ASQ49_04600	COG3775	system Galactitol-specific IIC component
ASQ49_04605	COG3414	Phosphotransferase system galactitol-specific IIB component
ASQ49_04610	COG1063	alcohol dehydrogenase
ASQ49_04620	COG0235	Class ii aldolase
ASQ49_04630	COG0726	polysaccharide deacetylase
ASQ49_04650	COG4139	cobalamin transport
ASQ49_04655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ASQ49_04670	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
ASQ49_04690	COG3328	transposase activity
ASQ49_04750	COG0714	Associated with various cellular activities
ASQ49_04760	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
ASQ49_04820	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ASQ49_04845	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ASQ49_04850	COG0039	L-malate dehydrogenase activity
ASQ49_04855	COG0281	malic enzyme
ASQ49_04870	COG0039	L-malate dehydrogenase activity
ASQ49_04940	COG1396	sequence-specific DNA binding
ASQ49_04955	COG1028	Short-chain dehydrogenase reductase Sdr
ASQ49_04980	COG1869	D-ribose catabolic process
ASQ49_04985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASQ49_04990	COG1879	ABC-type sugar transport system periplasmic component
ASQ49_04995	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASQ49_05000	COG1129	ABC transporter
ASQ49_05005	COG1609	Transcriptional regulator
ASQ49_05015	COG3266	domain, Protein
ASQ49_05020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ASQ49_05025	COG0187	DNA topoisomerase II activity
ASQ49_05035	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ASQ49_05040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ASQ49_05050	COG0592	DNA-directed DNA polymerase activity
ASQ49_05055	COG1136	(ABC) transporter
ASQ49_05055	COG0577	efflux transmembrane transporter activity
ASQ49_05060	COG0577	efflux transmembrane transporter activity
ASQ49_05060	COG1136	(ABC) transporter
ASQ49_05070	COG2076	Multidrug Resistance protein
ASQ49_05080	COG0706	membrane insertase activity
ASQ49_05090	COG0594	ribonuclease P activity
ASQ49_05095	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ASQ49_05105	COG0357	Ribosomal RNA small subunit methyltransferase G
ASQ49_05120	COG1192	Involved in chromosome partitioning
ASQ49_05130	COG1793	dna ligase
ASQ49_05130	COG3285	dna ligase
ASQ49_05145	COG1181	Belongs to the D-alanine--D-alanine ligase family
ASQ49_05150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_05170	COG1082	Xylose isomerase domain protein TIM barrel
ASQ49_05175	COG0673	inositol 2-dehydrogenase activity
ASQ49_05180	COG1082	Xylose isomerase domain protein TIM barrel
ASQ49_05190	COG2814	Major facilitator Superfamily
ASQ49_05195	COG1609	Transcriptional regulator
ASQ49_05200	COG2814	Major facilitator Superfamily
ASQ49_05205	COG0673	inositol 2-dehydrogenase activity
ASQ49_05215	COG0673	inositol 2-dehydrogenase activity
ASQ49_05225	COG2855	membrane
ASQ49_05235	COG1609	Transcriptional regulator
ASQ49_05245	COG1082	Xylose isomerase domain protein TIM barrel
ASQ49_05255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ASQ49_05270	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ASQ49_05270	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ASQ49_05290	COG0564	pseudouridine synthase activity
ASQ49_05300	COG1733	regulation of RNA biosynthetic process
ASQ49_05310	COG1609	Transcriptional regulator
ASQ49_05320	COG1653	transport
ASQ49_05330	COG0395	ABC-type sugar transport system, permease component
ASQ49_05345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASQ49_05355	COG2390	Transcriptional regulator
ASQ49_05360	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ASQ49_05365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ASQ49_05380	COG0515	serine threonine protein kinase
ASQ49_05380	COG2815	serine threonine protein kinase
ASQ49_05400	COG0385	Bile acid
ASQ49_05405	COG1012	belongs to the aldehyde dehydrogenase family
ASQ49_05410	COG0617	tRNA 3'-terminal CCA addition
ASQ49_05420	COG1929	Belongs to the glycerate kinase type-1 family
ASQ49_05430	COG0668	transmembrane transport
ASQ49_05445	COG0540	Belongs to the ATCase OTCase family
ASQ49_05450	COG1349	DNA-binding transcription factor activity
ASQ49_05460	COG2814	Major facilitator Superfamily
ASQ49_05475	COG1131	(ABC) transporter
ASQ49_05500	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ASQ49_05505	COG0114	fumarate hydratase activity
ASQ49_05515	COG3830	Belongs to the UPF0237 family
ASQ49_05520	COG2848	UPF0210 protein
ASQ49_05530	COG0038	chloride channel
ASQ49_05570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ASQ49_05580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASQ49_05625	COG2267	carboxylic ester hydrolase activity
ASQ49_05630	COG0686	Belongs to the AlaDH PNT family
ASQ49_05635	COG0205	6-phosphofructokinase activity
ASQ49_05645	COG0515	serine threonine protein kinase
ASQ49_05650	COG1131	(ABC) transporter
ASQ49_05650	COG1716	ATPase activity
ASQ49_05650	COG0842	Transport permease protein
ASQ49_05660	COG2146	nitrite reductase [NAD(P)H] activity
ASQ49_05675	COG3609	addiction module antidote protein, CC2985 family
ASQ49_05680	COG2337	Toxic component of a toxin-antitoxin (TA) module
ASQ49_05710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ASQ49_05735	COG1175	transmembrane transport
ASQ49_05745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ASQ49_05755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASQ49_05770	COG0534	Mate efflux family protein
ASQ49_05835	COG1113	amino acid transport
ASQ49_05845	COG1846	Transcriptional regulator
ASQ49_05850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ASQ49_05855	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ASQ49_05860	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
ASQ49_05865	COG0247	lactate metabolic process
ASQ49_05870	COG4585	Histidine kinase
ASQ49_05880	COG1136	(ABC) transporter
ASQ49_05880	COG0577	efflux transmembrane transporter activity
ASQ49_05905	COG1131	(ABC) transporter
ASQ49_05910	COG1051	belongs to the nudix hydrolase family
ASQ49_05915	COG2197	response regulator
ASQ49_05925	COG0277	FAD linked oxidase domain protein
ASQ49_05970	COG0300	oxidoreductase activity
ASQ49_05985	COG1022	Amp-dependent synthetase and ligase
ASQ49_05995	COG0672	)-iron permease
ASQ49_06005	COG2837	iron assimilation
ASQ49_06010	COG0360	Binds together with S18 to 16S ribosomal RNA
ASQ49_06020	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ASQ49_06025	COG0359	binds to the 23S rRNA
ASQ49_06040	COG1968	undecaprenyl-diphosphatase activity
ASQ49_06050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ASQ49_06055	COG1902	pentaerythritol trinitrate reductase activity
ASQ49_06080	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ASQ49_06090	COG2205	protein histidine kinase activity
ASQ49_06105	COG1609	Transcriptional regulator
ASQ49_06115	COG1175	transmembrane transport
ASQ49_06120	COG0395	ABC-type sugar transport system, permease component
ASQ49_06140	COG2423	ornithine cyclodeaminase activity
ASQ49_06155	COG1132	(ABC) transporter
ASQ49_06160	COG1132	(ABC) transporter
ASQ49_06175	COG0366	Alpha amylase catalytic
ASQ49_06180	COG0395	ABC-type sugar transport system, permease component
ASQ49_06215	COG1285	pathogenesis
ASQ49_06220	COG1175	transmembrane transport
ASQ49_06225	COG0395	ABC-type sugar transport system, permease component
ASQ49_06230	COG1653	transport
ASQ49_06240	COG0366	Alpha amylase catalytic
ASQ49_06290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ASQ49_06345	COG0477	Major facilitator Superfamily
ASQ49_06355	COG1063	alcohol dehydrogenase
ASQ49_06360	COG1830	Aldolase
ASQ49_06365	COG0656	L-ascorbic acid biosynthetic process
ASQ49_06370	COG0235	Class ii aldolase
ASQ49_06390	COG2390	Transcriptional regulator
ASQ49_06395	COG1621	beta-fructofuranosidase activity
ASQ49_06410	COG5002	protein histidine kinase activity
ASQ49_06440	COG1715	Restriction endonuclease
ASQ49_06485	COG0765	amino acid transport
ASQ49_06490	COG0765	amino acid transport
ASQ49_06495	COG1126	abc transporter atp-binding protein
ASQ49_06510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ASQ49_06515	COG0154	amidase activity
ASQ49_06565	COG0006	proline dipeptidase activity
ASQ49_06570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_06580	COG0477	Major facilitator Superfamily
ASQ49_06630	COG0022	dehydrogenase e1 component
ASQ49_06635	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASQ49_06645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ASQ49_06655	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ASQ49_06675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ASQ49_06695	COG3833	ABC-type maltose transport systems, permease component
ASQ49_06715	COG0561	phosphatase activity
ASQ49_06735	COG0137	argininosuccinate synthase activity
ASQ49_06740	COG0604	alcohol dehydrogenase
ASQ49_06740	COG3321	synthase
ASQ49_06740	COG1028	Short-chain dehydrogenase reductase Sdr
ASQ49_06765	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASQ49_06770	COG1609	Transcriptional regulator
ASQ49_06775	COG1316	TRANSCRIPTIONal
ASQ49_06800	COG0584	glycerophosphoryl diester phosphodiesterase
ASQ49_06805	COG4946	Tricorn protease homolog
ASQ49_06805	COG1506	peptidase
ASQ49_06805	COG0823	Involved in the tonB-independent uptake of proteins
ASQ49_06810	COG2130	NADP-dependent
ASQ49_06835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ASQ49_06890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ASQ49_06900	COG1174	glycine betaine transport
ASQ49_06910	COG1125	glycine betaine transport
ASQ49_06910	COG0517	IMP dehydrogenase activity
ASQ49_06915	COG3263	regulation of cellular component size
ASQ49_06930	COG0433	COG0433 Predicted ATPase
ASQ49_06950	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ASQ49_06960	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASQ49_06980	COG1942	4-Oxalocrotonate Tautomerase
ASQ49_06985	COG0673	inositol 2-dehydrogenase activity
ASQ49_06995	COG1946	Acyl-CoA thioesterase
ASQ49_07005	COG1063	alcohol dehydrogenase
ASQ49_07010	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ASQ49_07020	COG1064	alcohol dehydrogenase
ASQ49_07025	COG1069	ribulokinase activity
ASQ49_07030	COG1609	Transcriptional regulator
ASQ49_07040	COG0395	ABC-type sugar transport system, permease component
ASQ49_07045	COG1175	transmembrane transport
ASQ49_07050	COG1653	transport
ASQ49_07075	COG4221	oxidoreductase activity
ASQ49_07085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ASQ49_07095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_07105	COG0390	transport system, permease component
ASQ49_07115	COG1968	undecaprenyl-diphosphatase activity
ASQ49_07120	COG0745	RESPONSE REGULATOR receiver
ASQ49_07130	COG0438	transferase activity, transferring glycosyl groups
ASQ49_07140	COG0586	Pfam SNARE associated Golgi protein
ASQ49_07150	COG0445	tRNA wobble uridine modification
ASQ49_07155	COG0477	Major facilitator Superfamily
ASQ49_07190	COG3158	transport of potassium into the cell
ASQ49_07210	COG0667	Aldo Keto reductase
ASQ49_07215	COG4572	Cation transport regulator
ASQ49_07235	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ASQ49_07255	COG1295	ribonuclease BN
ASQ49_07265	COG1028	Short-chain dehydrogenase reductase Sdr
ASQ49_07270	COG0783	Belongs to the Dps family
ASQ49_07280	COG1028	Short-chain dehydrogenase reductase Sdr
ASQ49_07285	COG2124	cytochrome p450
ASQ49_07290	COG3285	dna ligase
ASQ49_07290	COG1793	dna ligase
ASQ49_07315	COG2197	response regulator
ASQ49_07370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ASQ49_07375	COG0534	Mate efflux family protein
ASQ49_07385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ASQ49_07400	COG1072	(Pantothenic acid kinase))
ASQ49_07405	COG1069	ribulokinase activity
ASQ49_07420	COG3022	response to hydroperoxide
ASQ49_07435	COG4608	Belongs to the ABC transporter superfamily
ASQ49_07440	COG0444	Belongs to the ABC transporter superfamily
ASQ49_07445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASQ49_07450	COG0601	transmembrane transport
ASQ49_07480	COG1846	Transcriptional regulator
ASQ49_07485	COG2040	homocysteine
ASQ49_07510	COG1408	metallophosphoesterase
ASQ49_07515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASQ49_07545	COG0494	nUDIX hydrolase
ASQ49_07630	COG1205	dead DEAH box helicase
ASQ49_07630	COG1111	helicase
ASQ49_07635	COG2890	protein-(glutamine-N5) methyltransferase activity
ASQ49_07645	COG1754	DNA topoisomerase type I activity
ASQ49_07645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASQ49_07655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ASQ49_07660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ASQ49_07670	COG1774	PSP1 C-terminal conserved region
ASQ49_07710	COG1231	oxidoreductase activity
ASQ49_07715	COG0431	NADPH-dependent FMN reductase
ASQ49_07745	COG0601	transmembrane transport
ASQ49_07750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASQ49_07765	COG1522	sequence-specific DNA binding
ASQ49_07810	COG2062	phosphohistidine phosphatase, SixA
ASQ49_07815	COG3458	cephalosporin-C deacetylase activity
ASQ49_07825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ASQ49_07835	COG0037	tRNA processing
ASQ49_07850	COG0302	gtp cyclohydrolase
ASQ49_07855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ASQ49_07860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ASQ49_07865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ASQ49_07880	COG0649	NAD binding
ASQ49_07885	COG2801	Transposase and inactivated derivatives
ASQ49_07895	COG0542	response to heat
ASQ49_07950	COG0457	Tetratricopeptide repeat
ASQ49_07950	COG0705	Rhomboid family
ASQ49_07955	COG0572	uridine kinase
ASQ49_07960	COG4143	(ABC) transporter
ASQ49_07970	COG3842	ATPase activity
ASQ49_07980	COG1194	a g-specific adenine glycosylase
ASQ49_07985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ASQ49_07990	COG0113	porphobilinogen synthase activity
ASQ49_08000	COG0181	hydroxymethylbilane synthase activity
ASQ49_08010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ASQ49_08015	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ASQ49_08035	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ASQ49_08040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ASQ49_08045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ASQ49_08055	COG1082	Xylose isomerase domain protein TIM barrel
ASQ49_08060	COG0506	proline dehydrogenase activity
ASQ49_08075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ASQ49_08085	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ASQ49_08090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASQ49_08090	COG1648	precorrin-2 dehydrogenase activity
ASQ49_08095	COG0406	alpha-ribazole phosphatase activity
ASQ49_08100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ASQ49_08105	COG0785	Cytochrome C biogenesis protein
ASQ49_08115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASQ49_08135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ASQ49_08140	COG2409	Drug exporters of the RND superfamily
ASQ49_08150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ASQ49_08155	COG0129	dihydroxy-acid dehydratase activity
ASQ49_08175	COG1120	ATPase activity
ASQ49_08180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASQ49_08185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASQ49_08190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ASQ49_08195	COG0803	Belongs to the bacterial solute-binding protein 9 family
ASQ49_08205	COG1121	(ABC) transporter
ASQ49_08210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASQ49_08220	COG0523	cobalamin synthesis protein
ASQ49_08230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ASQ49_08235	COG0254	rRNA binding
ASQ49_08250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ASQ49_08255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ASQ49_08280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ASQ49_08285	COG0745	RESPONSE REGULATOR receiver
ASQ49_08315	COG1490	D-aminoacyl-tRNA deacylase activity
ASQ49_08320	COG3485	protocatechuate 3,4-dioxygenase
ASQ49_08330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ASQ49_08345	COG2337	Toxic component of a toxin-antitoxin (TA) module
ASQ49_08360	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASQ49_08365	COG1937	Protein conserved in bacteria
ASQ49_08380	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ASQ49_08385	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
ASQ49_08390	COG4423	Transcription factor
ASQ49_08395	COG0151	Belongs to the GarS family
ASQ49_08400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ASQ49_08410	COG3634	alkyl hydroperoxide reductase activity
ASQ49_08415	COG0450	alkyl hydroperoxide reductase
ASQ49_08420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ASQ49_08425	COG0047	phosphoribosylformylglycinamidine synthase activity
ASQ49_08430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ASQ49_08440	COG1113	amino acid transport
ASQ49_08445	COG0252	asparaginase activity
ASQ49_08460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ASQ49_08500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ASQ49_08525	COG0395	ABC-type sugar transport system, permease component
ASQ49_08645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASQ49_08660	COG3848	Pyruvate phosphate dikinase
ASQ49_08660	COG0574	Belongs to the PEP-utilizing enzyme family
ASQ49_08705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASQ49_08715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASQ49_08735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ASQ49_08740	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASQ49_08755	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ASQ49_08755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASQ49_08755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASQ49_08760	COG1461	Dihydroxyacetone kinase
ASQ49_08765	COG2376	Dihydroxyacetone kinase
ASQ49_08785	COG1132	(ABC) transporter
ASQ49_08795	COG2226	methyltransferase
ASQ49_08800	COG1131	(ABC) transporter
ASQ49_08825	COG0644	oxidoreductase
ASQ49_08835	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASQ49_08840	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASQ49_08845	COG0649	NAD binding
ASQ49_08855	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ASQ49_08860	COG1034	ATP synthesis coupled electron transport
ASQ49_08865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ASQ49_08870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASQ49_08880	COG0713	ATP synthesis coupled electron transport
ASQ49_08895	COG1007	ATP synthesis coupled electron transport
ASQ49_08950	COG3590	peptidase
ASQ49_08955	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASQ49_08960	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASQ49_08960	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASQ49_08965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASQ49_08970	COG0649	NAD binding
ASQ49_08970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASQ49_08975	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASQ49_09015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ASQ49_09020	COG2030	dehydratase
ASQ49_09030	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ASQ49_09035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_09050	COG0250	Participates in transcription elongation, termination and antitermination
ASQ49_09055	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ASQ49_09060	COG0081	regulation of translation
ASQ49_09070	COG0222	ribosome binding
ASQ49_09075	COG0085	RNA polymerase activity
ASQ49_09080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASQ49_09100	COG0673	inositol 2-dehydrogenase activity
ASQ49_09105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ASQ49_09110	COG0049	tRNA binding
ASQ49_09115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASQ49_09120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASQ49_09135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASQ49_09140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASQ49_09145	COG0051	transcription antitermination factor activity, RNA binding
ASQ49_09150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ASQ49_09155	COG0088	Forms part of the polypeptide exit tunnel
ASQ49_09160	COG0089	rRNA binding
ASQ49_09165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ASQ49_09170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ASQ49_09175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ASQ49_09180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ASQ49_09185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ASQ49_09190	COG0255	Belongs to the universal ribosomal protein uL29 family
ASQ49_09195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ASQ49_09215	COG1175	transmembrane transport
ASQ49_09220	COG0395	ABC-type sugar transport system, permease component
ASQ49_09225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASQ49_09230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ASQ49_09235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ASQ49_09240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ASQ49_09245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ASQ49_09250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ASQ49_09255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ASQ49_09260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ASQ49_09265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ASQ49_09270	COG1841	ribosomal large subunit assembly
ASQ49_09275	COG0200	Binds to the 23S rRNA
ASQ49_09310	COG0563	adenylate kinase activity
ASQ49_09330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ASQ49_09335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ASQ49_09340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ASQ49_09345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ASQ49_09350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ASQ49_09355	COG0202	RNA polymerase activity
ASQ49_09360	COG0203	ribosomal protein L17
ASQ49_09365	COG0438	transferase activity, transferring glycosyl groups
ASQ49_09375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASQ49_09375	COG0519	Catalyzes the synthesis of GMP from XMP
ASQ49_09390	COG3845	ABC transporter
ASQ49_09395	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ASQ49_09410	COG0101	tRNA pseudouridine synthase activity
ASQ49_09415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ASQ49_09435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ASQ49_09440	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ASQ49_09450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASQ49_09460	COG1072	(Pantothenic acid kinase))
ASQ49_09470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASQ49_09475	COG0736	holo-[acyl-carrier-protein] synthase activity
ASQ49_09490	COG0513	Belongs to the DEAD box helicase family
ASQ49_09495	COG0802	atpase or kinase
ASQ49_09500	COG1214	PFAM Peptidase M22, glycoprotease
ASQ49_09500	COG0456	acetyltransferase
ASQ49_09510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASQ49_09530	COG1355	regulation of microtubule-based process
ASQ49_09550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ASQ49_09555	COG0459	protein refolding
ASQ49_09575	COG1605	Chorismate mutase
ASQ49_09575	COG0287	Prephenate dehydrogenase
ASQ49_09580	COG1045	serine acetyltransferase
ASQ49_09585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASQ49_09585	COG0519	Catalyzes the synthesis of GMP from XMP
ASQ49_09610	COG2197	response regulator
ASQ49_09615	COG2261	transglycosylase associated protein
ASQ49_09625	COG2011	ABC-type metal ion transport system permease component
ASQ49_09630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ASQ49_09635	COG1464	Belongs to the NlpA lipoprotein family
ASQ49_09645	COG2801	Transposase and inactivated derivatives
ASQ49_09660	COG0045	succinate-CoA ligase (ADP-forming) activity
ASQ49_09690	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASQ49_09690	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASQ49_09695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ASQ49_09705	COG0138	bifunctional purine biosynthesis protein purh
ASQ49_09715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ASQ49_09730	COG0039	L-malate dehydrogenase activity
ASQ49_09750	COG1253	flavin adenine dinucleotide binding
ASQ49_09790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASQ49_09810	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ASQ49_09825	COG4656	Part of a membrane complex involved in electron transport
ASQ49_09830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASQ49_09845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASQ49_09865	COG4770	biotin carboxylase activity
ASQ49_09875	COG0351	phosphomethylpyrimidine kinase
ASQ49_09885	COG4221	oxidoreductase activity
ASQ49_09900	COG0424	maF-like protein
ASQ49_09910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASQ49_09920	COG3340	Belongs to the peptidase S51 family
ASQ49_09940	COG1316	TRANSCRIPTIONal
ASQ49_09955	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ASQ49_09955	COG0662	Cupin 2, conserved barrel domain protein
ASQ49_10045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ASQ49_10060	COG1918	ferrous iron import across plasma membrane
ASQ49_10060	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ASQ49_10070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ASQ49_10075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ASQ49_10080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ASQ49_10085	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ASQ49_10090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ASQ49_10095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ASQ49_10120	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ASQ49_10145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ASQ49_10160	COG0587	DNA-directed DNA polymerase activity
ASQ49_10170	COG0531	amino acid
ASQ49_10175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASQ49_10180	COG2855	membrane
ASQ49_10200	COG1131	(ABC) transporter
ASQ49_10215	COG1113	amino acid transport
ASQ49_10225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ASQ49_10235	COG4585	Histidine kinase
ASQ49_10240	COG2197	response regulator
ASQ49_10245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ASQ49_10260	COG2226	methyltransferase
ASQ49_10265	COG0384	phenazine biosynthesis protein PhzF
ASQ49_10270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ASQ49_10275	COG1794	racemase activity, acting on amino acids and derivatives
ASQ49_10315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ASQ49_10335	COG1794	racemase activity, acting on amino acids and derivatives
ASQ49_10340	COG0519	Catalyzes the synthesis of GMP from XMP
ASQ49_10350	COG4106	trans-aconitate 2-methyltransferase activity
ASQ49_10360	COG2801	Transposase and inactivated derivatives
ASQ49_10365	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ASQ49_10395	COG0277	FAD linked oxidase domain protein
ASQ49_10395	COG0247	lactate metabolic process
ASQ49_10410	COG1022	Amp-dependent synthetase and ligase
ASQ49_10425	COG2814	Major facilitator Superfamily
ASQ49_10435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ASQ49_10450	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ASQ49_10455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ASQ49_10470	COG0698	ribose 5-phosphate isomerase
ASQ49_10490	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ASQ49_10490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ASQ49_10510	COG0544	peptidyl-prolyl cis-trans isomerase activity
ASQ49_10520	COG0740	serine-type endopeptidase activity
ASQ49_10525	COG0740	serine-type endopeptidase activity
ASQ49_10530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ASQ49_10540	COG4946	Tricorn protease homolog
ASQ49_10540	COG0793	Belongs to the peptidase S41A family
ASQ49_10555	COG0525	valine-tRNA ligase activity
ASQ49_10565	COG0363	glucosamine-6-phosphate deaminase activity
ASQ49_10580	COG0109	protoheme IX farnesyltransferase activity
ASQ49_10585	COG1612	heme a metabolic process
ASQ49_10595	COG1131	(ABC) transporter
ASQ49_10600	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ASQ49_10605	COG1609	Transcriptional regulator
ASQ49_10610	COG3833	ABC-type maltose transport systems, permease component
ASQ49_10615	COG1175	transmembrane transport
ASQ49_10630	COG0719	Fe-S assembly protein
ASQ49_10645	COG0396	ATPase activity
ASQ49_10650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASQ49_10700	COG0488	(ABC) transporter
ASQ49_10730	COG1028	Short-chain dehydrogenase reductase Sdr
ASQ49_10755	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ASQ49_10760	COG1119	ATPase activity
ASQ49_10800	COG0242	peptide deformylase activity
ASQ49_10810	COG4974	Belongs to the 'phage' integrase family
ASQ49_10825	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ASQ49_10830	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ASQ49_10835	COG0714	Associated with various cellular activities
ASQ49_10840	COG3831	ATPase activity
ASQ49_10850	COG0052	Belongs to the universal ribosomal protein uS2 family
ASQ49_10855	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ASQ49_10860	COG0528	UMP kinase activity
ASQ49_10865	COG0233	cytoplasmic translational termination
ASQ49_10870	COG0575	Belongs to the CDS family
ASQ49_10875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ASQ49_10880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ASQ49_10890	COG0750	zinc metalloprotease
ASQ49_10895	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ASQ49_10925	COG1305	Transglutaminase-like
ASQ49_10935	COG0442	prolyl-tRNA aminoacylation
ASQ49_10955	COG0779	Required for maturation of 30S ribosomal subunits
ASQ49_10970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASQ49_10975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ASQ49_10980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ASQ49_10985	COG0371	Dehydrogenase
ASQ49_11000	COG3732	PTS system glucitol sorbitol-specific
ASQ49_11020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ASQ49_11040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ASQ49_11045	COG1185	polyribonucleotide nucleotidyltransferase activity
ASQ49_11050	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ASQ49_11060	COG0028	Belongs to the TPP enzyme family
ASQ49_11070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ASQ49_11075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ASQ49_11095	COG0742	ribosomal rna small subunit methyltransferase
ASQ49_11100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ASQ49_11110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ASQ49_11115	COG0571	ribonuclease III activity
ASQ49_11120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ASQ49_11125	COG0656	L-ascorbic acid biosynthetic process
ASQ49_11200	COG0228	four-way junction DNA binding
ASQ49_11205	COG1837	Belongs to the UPF0109 family
ASQ49_11210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ASQ49_11215	COG0336	Belongs to the RNA methyltransferase TrmD family
ASQ49_11225	COG1053	succinate dehydrogenase
ASQ49_11230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ASQ49_11235	COG0335	large ribosomal subunit rRNA binding
ASQ49_11240	COG0681	Belongs to the peptidase S26 family
ASQ49_11245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ASQ49_11255	COG0792	nuclease activity
ASQ49_11260	COG0606	chelatase, subunit chli
ASQ49_11290	COG0395	ABC-type sugar transport system, permease component
ASQ49_11295	COG1609	Transcriptional regulator
ASQ49_11305	COG0395	ABC-type sugar transport system, permease component
ASQ49_11335	COG2160	L-arabinose isomerase activity
ASQ49_11340	COG1609	Transcriptional regulator
ASQ49_11350	COG3415	Transposase
ASQ49_11350	COG2801	Transposase and inactivated derivatives
ASQ49_11375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASQ49_11385	COG0667	Aldo Keto reductase
ASQ49_11395	COG3201	nicotinamide mononucleotide transporter
ASQ49_11400	COG0140	phosphoribosyl-ATP diphosphatase activity
ASQ49_11405	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ASQ49_11440	COG0647	UMP catabolic process
ASQ49_11445	COG1268	BioY protein
ASQ49_11450	COG1122	ATPase activity
ASQ49_11465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ASQ49_11470	COG0497	DNA recombination
ASQ49_11475	COG0504	CTP synthase activity
ASQ49_11510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASQ49_11530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASQ49_11550	COG0107	imidazoleglycerol-phosphate synthase activity
ASQ49_11555	COG0537	adenosine 5'-monophosphoramidase activity
ASQ49_11565	COG0440	acetolactate synthase activity
ASQ49_11570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASQ49_11590	COG0473	3-isopropylmalate dehydrogenase activity
ASQ49_11595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ASQ49_11600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASQ49_11610	COG0179	Fumarylacetoacetate (FAA) hydrolase
ASQ49_11630	COG1414	Transcriptional regulator
ASQ49_11635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ASQ49_11640	COG0066	3-isopropylmalate dehydratase activity
ASQ49_11650	COG1181	Belongs to the D-alanine--D-alanine ligase family
ASQ49_11660	COG2801	Transposase and inactivated derivatives
ASQ49_11670	COG1674	ftsk spoiiie
ASQ49_11680	COG3152	Membrane
ASQ49_11695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ASQ49_11700	COG2884	Cell division ATP-binding protein ftsE
ASQ49_11705	COG2177	Part of the ABC transporter FtsEX involved in
ASQ49_11710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ASQ49_11715	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ASQ49_11725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASQ49_11735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ASQ49_11740	COG0165	Argininosuccinate lyase
ASQ49_11755	COG1678	Uncharacterized ACR, COG1678
ASQ49_11760	COG0745	RESPONSE REGULATOR receiver
ASQ49_11765	COG5002	protein histidine kinase activity
ASQ49_11770	COG5401	PFAM Sporulation and spore germination
ASQ49_11780	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ASQ49_11790	COG0653	protein targeting
ASQ49_11810	COG0613	PHP domain protein
ASQ49_11820	COG0180	Tryptophanyl-tRNA synthetase
ASQ49_11845	COG1278	Cold shock
ASQ49_11850	COG0210	DNA helicase
ASQ49_11870	COG1074	ATP-dependent DNA helicase activity
ASQ49_11875	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ASQ49_11900	COG3480	Lon protease (S16) C-terminal proteolytic domain
ASQ49_11910	COG1615	UPF0182 protein
ASQ49_11940	COG0747	negative chemotaxis
ASQ49_11965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASQ49_11970	COG0483	inositol monophosphate 1-phosphatase activity
ASQ49_11980	COG1162	GTPase activity
ASQ49_11985	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ASQ49_11995	COG1595	DNA-templated transcription, initiation
ASQ49_12020	COG0567	Dehydrogenase, E1 component
ASQ49_12020	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASQ49_12030	COG1611	Belongs to the LOG family
ASQ49_12040	COG0019	diaminopimelate decarboxylase activity
ASQ49_12045	COG0460	homoserine dehydrogenase
ASQ49_12050	COG0083	homoserine kinase activity
ASQ49_12060	COG0254	rRNA binding
ASQ49_12065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ASQ49_12070	COG2890	protein-(glutamine-N5) methyltransferase activity
ASQ49_12150	COG0318	PFAM AMP-dependent synthetase and ligase
ASQ49_12160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ASQ49_12165	COG0367	asparagine synthase
ASQ49_12175	COG1045	serine acetyltransferase
ASQ49_12190	COG0356	it plays a direct role in the translocation of protons across the membrane
ASQ49_12195	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ASQ49_12200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ASQ49_12205	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ASQ49_12210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ASQ49_12215	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ASQ49_12220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ASQ49_12225	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ASQ49_12280	COG0033	Phosphoglucomutase
ASQ49_12290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASQ49_12305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ASQ49_12310	COG3281	Trehalose synthase
ASQ49_12315	COG0366	Alpha amylase catalytic
ASQ49_12340	COG0482	sulfurtransferase activity
ASQ49_12355	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ASQ49_12380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASQ49_12385	COG0154	amidase activity
ASQ49_12390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASQ49_12395	COG2233	PERMEase
ASQ49_12400	COG2233	PERMEase
ASQ49_12415	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ASQ49_12420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASQ49_12435	COG0134	indole-3-glycerol-phosphate synthase activity
ASQ49_12445	COG0159	tryptophan synthase activity
ASQ49_12450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ASQ49_12455	COG0069	glutamate synthase activity
ASQ49_12455	COG0070	glutamate synthase
ASQ49_12455	COG0067	glutamate synthase
ASQ49_12475	COG0395	ABC-type sugar transport system, permease component
ASQ49_12510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ASQ49_12515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASQ49_12520	COG0131	Imidazoleglycerol-phosphate dehydratase
ASQ49_12525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ASQ49_12530	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ASQ49_12535	COG0217	transcriptional regulatory protein
ASQ49_12540	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ASQ49_12545	COG0632	four-way junction helicase activity
ASQ49_12550	COG2255	four-way junction helicase activity
ASQ49_12560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASQ49_12565	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASQ49_12570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ASQ49_12580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ASQ49_12585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ASQ49_12590	COG1196	nuclear chromosome segregation
ASQ49_12595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASQ49_12600	COG0124	histidyl-tRNA synthetase
ASQ49_12610	COG1309	transcriptional regulator
ASQ49_12625	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ASQ49_12660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ASQ49_12665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ASQ49_12670	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ASQ49_12675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ASQ49_12680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ASQ49_12685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ASQ49_12690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ASQ49_12700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ASQ49_12705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASQ49_12715	COG0194	GDP metabolic process
ASQ49_12720	COG1758	RNA polymerase activity
ASQ49_12730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ASQ49_12735	COG1201	RNA secondary structure unwinding
ASQ49_12740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ASQ49_12770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ASQ49_12780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ASQ49_12790	COG1410	methionine synthase
ASQ49_12790	COG0646	methionine synthase
ASQ49_12805	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASQ49_12810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASQ49_12820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ASQ49_12825	COG1160	GTP binding
ASQ49_12835	COG1764	response to oxidative stress
ASQ49_12865	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ASQ49_12895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ASQ49_12905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_12925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASQ49_12935	COG0277	FAD linked oxidase domain protein
ASQ49_12995	COG3550	peptidyl-serine autophosphorylation
ASQ49_13025	COG2807	transmembrane transport
ASQ49_13050	COG0427	acetyl-CoA hydrolase
ASQ49_13055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ASQ49_13060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ASQ49_13060	COG2813	Specifically methylates the guanine in position
ASQ49_13065	COG1522	sequence-specific DNA binding
ASQ49_13070	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ASQ49_13075	COG1216	Glycosyl transferase, family 2
ASQ49_13090	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ASQ49_13095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ASQ49_13105	COG1966	Carbon starvation protein
ASQ49_13120	COG0531	amino acid
ASQ49_13170	COG1739	Uncharacterized protein family UPF0029
ASQ49_13175	COG1472	Belongs to the glycosyl hydrolase 3 family
ASQ49_13190	COG0009	L-threonylcarbamoyladenylate synthase
ASQ49_13200	COG0205	6-phosphofructokinase activity
ASQ49_13205	COG1295	ribonuclease BN
ASQ49_13225	COG1716	ATPase activity
ASQ49_13255	COG0438	transferase activity, transferring glycosyl groups
ASQ49_13260	COG1560	Kdo2-lipid A biosynthetic process
ASQ49_13275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ASQ49_13280	COG1064	alcohol dehydrogenase
ASQ49_13310	COG0726	polysaccharide deacetylase
ASQ49_13340	COG2326	polyphosphate kinase activity
ASQ49_13345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASQ49_13360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ASQ49_13365	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ASQ49_13370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASQ49_13375	COG0531	amino acid
ASQ49_13380	COG0569	domain protein
ASQ49_13400	COG0756	dUTP diphosphatase activity
ASQ49_13435	COG1297	OPT oligopeptide transporter protein
ASQ49_13445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ASQ49_13465	COG0187	DNA topoisomerase II activity
ASQ49_13480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ASQ49_13490	COG1643	Atp-dependent helicase
ASQ49_13510	COG0717	Belongs to the dCTP deaminase family
ASQ49_13515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASQ49_13520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ASQ49_13535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ASQ49_13540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ASQ49_13545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ASQ49_13555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASQ49_13565	COG1418	mRNA catabolic process
ASQ49_13570	COG2137	regulation of response to DNA damage stimulus
ASQ49_13585	COG1349	DNA-binding transcription factor activity
ASQ49_13595	COG1546	Belongs to the CinA family
ASQ49_13595	COG1058	Belongs to the CinA family
ASQ49_13605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASQ49_13635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ASQ49_13640	COG0284	orotidine-5'-phosphate decarboxylase activity
ASQ49_13645	COG0167	dihydroorotate dehydrogenase activity
ASQ49_13650	COG0543	2 iron, 2 sulfur cluster binding
ASQ49_13655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ASQ49_13665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASQ49_13680	COG0667	Aldo Keto reductase
ASQ49_13690	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ASQ49_13705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ASQ49_13715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASQ49_13720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ASQ49_13745	COG2304	oxidoreductase activity
ASQ49_13755	COG0714	Associated with various cellular activities
ASQ49_13785	COG0477	Major facilitator Superfamily
ASQ49_13790	COG1309	transcriptional regulator
ASQ49_13795	COG0515	serine threonine protein kinase
ASQ49_13805	COG0583	DNA-binding transcription factor activity
ASQ49_13815	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ASQ49_13825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_13845	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ASQ49_13870	COG1191	sigma factor activity
ASQ49_13875	COG0358	DNA primase activity
ASQ49_13880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ASQ49_13910	COG1053	succinate dehydrogenase
ASQ49_13920	COG0076	glutamate decarboxylase activity
ASQ49_13930	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ASQ49_13935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ASQ49_13945	COG0423	glycine-tRNA ligase activity
ASQ49_13955	COG0735	belongs to the Fur family
ASQ49_13980	COG4716	Myosin-crossreactive antigen
ASQ49_13985	COG1063	alcohol dehydrogenase
ASQ49_13990	COG1381	Involved in DNA repair and RecF pathway recombination
ASQ49_13995	COG1404	Belongs to the peptidase S8 family
ASQ49_14005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASQ49_14020	COG0765	amino acid transport
ASQ49_14025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASQ49_14030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASQ49_14040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ASQ49_14050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ASQ49_14070	COG2226	methyltransferase
ASQ49_14110	COG4152	abc transporter atp-binding protein
ASQ49_14115	COG2197	response regulator
ASQ49_14125	COG0343	queuine tRNA-ribosyltransferase activity
ASQ49_14130	COG5006	permease, DMT superfamily
ASQ49_14135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASQ49_14150	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASQ49_14150	COG2213	PTS system mannitol-specific
ASQ49_14155	COG1063	alcohol dehydrogenase
ASQ49_14165	COG0484	heat shock protein binding
ASQ49_14170	COG1420	regulation of RNA biosynthetic process
ASQ49_14180	COG0483	inositol monophosphate 1-phosphatase activity
ASQ49_14200	COG1175	transmembrane transport
ASQ49_14205	COG0395	ABC-type sugar transport system, permease component
ASQ49_14215	COG0477	Major facilitator Superfamily
ASQ49_14220	COG1309	transcriptional regulator
ASQ49_14225	COG1131	(ABC) transporter
ASQ49_14240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASQ49_14245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASQ49_14255	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ASQ49_14265	COG1169	isochorismate synthase
ASQ49_14270	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ASQ49_14275	COG4948	Mandelate Racemase Muconate Lactonizing
ASQ49_14295	COG0481	GTPase activity
ASQ49_14305	COG0268	Binds directly to 16S ribosomal RNA
ASQ49_14315	COG1061	Type III restriction enzyme res subunit
ASQ49_14320	COG0658	competence protein
ASQ49_14320	COG2333	competence protein COMEC
ASQ49_14330	COG0495	leucyl-tRNA aminoacylation
ASQ49_14345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ASQ49_14355	COG0590	tRNA wobble adenosine to inosine editing
ASQ49_14430	COG0488	(ABC) transporter
ASQ49_14510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ASQ49_14515	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ASQ49_14520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ASQ49_14525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASQ49_14535	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ASQ49_14540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ASQ49_14545	COG1530	ribonuclease E activity
ASQ49_14555	COG1472	Belongs to the glycosyl hydrolase 3 family
ASQ49_14565	COG0105	UTP biosynthetic process
ASQ49_14575	COG0285	dihydrofolate synthase activity
ASQ49_14585	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ASQ49_14590	COG0149	triose-phosphate isomerase activity
ASQ49_14595	COG0126	phosphoglycerate kinase activity
ASQ49_14600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASQ49_14605	COG1481	regulation of sporulation
ASQ49_14610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ASQ49_14615	COG1660	Displays ATPase and GTPase activities
ASQ49_14620	COG0322	excinuclease ABC activity
ASQ49_14640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASQ49_14655	COG0556	nucleotide-excision repair
ASQ49_14670	COG0237	dephospho-CoA kinase activity
ASQ49_14675	COG0539	negative regulation of cytoplasmic translation
ASQ49_14700	COG2050	protein possibly involved in aromatic compounds catabolism
ASQ49_14715	COG0469	pyruvate kinase activity
ASQ49_14725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ASQ49_14730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ASQ49_14745	COG1799	cell septum assembly
ASQ49_14755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ASQ49_14765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ASQ49_14770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ASQ49_14775	COG0772	Belongs to the SEDS family
ASQ49_14780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ASQ49_14785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ASQ49_14790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ASQ49_14800	COG0768	penicillin binding
ASQ49_14810	COG0275	rRNA processing
ASQ49_14815	COG2001	Belongs to the MraZ family
ASQ49_14820	COG0714	Associated with various cellular activities
ASQ49_14840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ASQ49_14845	COG0509	glycine decarboxylation via glycine cleavage system
ASQ49_14850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASQ49_14850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASQ49_14855	COG1131	(ABC) transporter
ASQ49_14875	COG3265	gluconokinase activity
ASQ49_14885	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ASQ49_14895	COG0596	Alpha beta hydrolase
ASQ49_14900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ASQ49_14900	COG1116	anion transmembrane transporter activity
ASQ49_14920	COG0210	DNA helicase
ASQ49_14925	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ASQ49_14935	COG0352	thiamine-phosphate diphosphorylase activity
ASQ49_14945	COG2815	serine threonine protein kinase
ASQ49_14945	COG0515	serine threonine protein kinase
ASQ49_14960	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ASQ49_14965	COG2197	response regulator
ASQ49_14985	COG1940	carbohydrate kinase activity
ASQ49_15030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ASQ49_15040	COG1845	cytochrome c oxidase, subunit III
ASQ49_15045	COG2010	Cytochrome c
ASQ49_15050	COG0723	plastoquinol--plastocyanin reductase activity
ASQ49_15055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ASQ49_15075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ASQ49_15080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ASQ49_15120	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASQ49_15125	COG0321	lipoyl(octanoyl) transferase activity
ASQ49_15140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ASQ49_15150	COG0488	(ABC) transporter
ASQ49_15155	COG2239	Acts as a magnesium transporter
ASQ49_15160	COG0586	Pfam SNARE associated Golgi protein
ASQ49_15180	COG0174	glutamine synthetase
ASQ49_15190	COG3093	addiction module antidote protein HigA
ASQ49_15205	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ASQ49_15215	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ASQ49_15240	COG0598	Magnesium transport protein CorA
ASQ49_15255	COG0531	amino acid
ASQ49_15260	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ASQ49_15275	COG0006	proline dipeptidase activity
ASQ49_15310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASQ49_15315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASQ49_15345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ASQ49_15350	COG0297	glycogen (starch) synthase activity
ASQ49_15360	COG1611	Belongs to the LOG family
ASQ49_15370	COG2171	N-acyltransferase activity
ASQ49_15395	COG2720	vancomycin resistance protein
ASQ49_15400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ASQ49_15405	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ASQ49_15410	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ASQ49_15415	COG2814	Major facilitator Superfamily
ASQ49_15465	COG0647	UMP catabolic process
ASQ49_15475	COG0698	ribose 5-phosphate isomerase
ASQ49_15480	COG1349	DNA-binding transcription factor activity
ASQ49_15485	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ASQ49_15490	COG2376	Dihydroxyacetone kinase
ASQ49_15495	COG1063	alcohol dehydrogenase
ASQ49_15500	COG1012	belongs to the aldehyde dehydrogenase family
ASQ49_15520	COG1121	(ABC) transporter
ASQ49_15525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASQ49_15545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASQ49_15555	COG0765	amino acid transport
ASQ49_15575	COG2501	S4 domain
ASQ49_15610	COG0833	amino acid
ASQ49_15625	COG2133	pyrroloquinoline quinone binding
ASQ49_15630	COG2716	regulation of RNA biosynthetic process
ASQ49_15655	COG0477	Major facilitator Superfamily
ASQ49_15660	COG0477	Major facilitator Superfamily
ASQ49_15665	COG0604	alcohol dehydrogenase
ASQ49_15665	COG1028	Short-chain dehydrogenase reductase Sdr
ASQ49_15665	COG3321	synthase
ASQ49_15690	COG1335	isochorismatase
ASQ49_15695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ASQ49_15715	COG0406	alpha-ribazole phosphatase activity
ASQ49_15720	COG1132	(ABC) transporter
ASQ49_15735	COG1397	ADP-ribosylglycohydrolase
ASQ49_15810	COG3549	Plasmid maintenance system killer
ASQ49_15820	COG1131	(ABC) transporter
ASQ49_15825	COG3559	Exporter of polyketide antibiotics
ASQ49_15845	COG3549	Plasmid maintenance system killer
ASQ49_15915	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ASQ49_15925	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ASQ49_15930	COG0012	GTP binding
ASQ49_15945	COG0577	efflux transmembrane transporter activity
ASQ49_15945	COG1136	(ABC) transporter
ASQ49_15950	COG0577	efflux transmembrane transporter activity
ASQ49_15950	COG1136	(ABC) transporter
ASQ49_15955	COG1362	aminopeptidase activity
ASQ49_15960	COG1322	Protein conserved in bacteria
ASQ49_15965	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ASQ49_15970	COG1570	exodeoxyribonuclease VII activity
ASQ49_15975	COG1722	exodeoxyribonuclease VII activity
ASQ49_15985	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ASQ49_15995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASQ49_16000	COG1331	Highly conserved protein containing a thioredoxin domain
ASQ49_16015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ASQ49_16030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ASQ49_16035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASQ49_16070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASQ49_16085	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ASQ49_16090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASQ49_16090	COG0072	phenylalanine-tRNA ligase activity
ASQ49_16095	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ASQ49_16110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASQ49_16115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ASQ49_16120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ASQ49_16125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ASQ49_16165	COG1834	amidinotransferase
ASQ49_16185	COG2837	iron assimilation
ASQ49_16215	COG0148	phosphopyruvate hydratase activity
ASQ49_16235	COG0193	aminoacyl-tRNA hydrolase activity
ASQ49_16240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ASQ49_16245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ASQ49_16250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASQ49_16260	COG1309	transcriptional regulator
ASQ49_16265	COG1846	Transcriptional regulator
ASQ49_16270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ASQ49_16275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ASQ49_16280	COG0084	hydrolase, TatD family'
ASQ49_16295	COG2233	PERMEase
ASQ49_16305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ASQ49_16350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASQ49_16365	COG0693	protein deglycase activity
ASQ49_16375	COG0789	Transcriptional regulator
ASQ49_16405	COG1053	succinate dehydrogenase
ASQ49_16430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ASQ49_16495	COG2801	Transposase and inactivated derivatives
ASQ49_16505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD