locus-tag	class	description
A8L58_00025	COG2837	iron assimilation
A8L58_00030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8L58_00080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A8L58_00085	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A8L58_00090	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A8L58_00095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8L58_00110	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A8L58_00115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8L58_00115	COG0072	phenylalanine-tRNA ligase activity
A8L58_00120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A8L58_00135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A8L58_00170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8L58_00175	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A8L58_00190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8L58_00205	COG1331	Highly conserved protein containing a thioredoxin domain
A8L58_00215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A8L58_00225	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A8L58_00235	COG1722	exodeoxyribonuclease VII activity
A8L58_00240	COG1570	exodeoxyribonuclease VII activity
A8L58_00245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A8L58_00250	COG1322	Protein conserved in bacteria
A8L58_00255	COG1362	aminopeptidase activity
A8L58_00260	COG0577	efflux transmembrane transporter activity
A8L58_00260	COG1136	(ABC) transporter
A8L58_00265	COG0577	efflux transmembrane transporter activity
A8L58_00265	COG1136	(ABC) transporter
A8L58_00280	COG0012	GTP binding
A8L58_00365	COG1397	ADP-ribosylglycohydrolase
A8L58_00380	COG1132	(ABC) transporter
A8L58_00385	COG0406	alpha-ribazole phosphatase activity
A8L58_00405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8L58_00410	COG1335	isochorismatase
A8L58_00435	COG0604	alcohol dehydrogenase
A8L58_00435	COG3321	synthase
A8L58_00435	COG1028	Short-chain dehydrogenase reductase Sdr
A8L58_00440	COG0477	Major facilitator Superfamily
A8L58_00445	COG0477	Major facilitator Superfamily
A8L58_00470	COG2716	regulation of RNA biosynthetic process
A8L58_00475	COG2133	pyrroloquinoline quinone binding
A8L58_00490	COG0833	amino acid
A8L58_00525	COG2501	S4 domain
A8L58_00540	COG1126	abc transporter atp-binding protein
A8L58_00545	COG0765	amino acid transport
A8L58_00575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8L58_00580	COG1121	(ABC) transporter
A8L58_00600	COG1012	belongs to the aldehyde dehydrogenase family
A8L58_00605	COG1063	alcohol dehydrogenase
A8L58_00610	COG2376	Dihydroxyacetone kinase
A8L58_00615	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A8L58_00620	COG1349	DNA-binding transcription factor activity
A8L58_00625	COG0698	ribose 5-phosphate isomerase
A8L58_00635	COG0647	UMP catabolic process
A8L58_00645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A8L58_00680	COG2814	Major facilitator Superfamily
A8L58_00685	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A8L58_00690	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A8L58_00695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8L58_00700	COG2720	vancomycin resistance protein
A8L58_00725	COG2171	N-acyltransferase activity
A8L58_00735	COG1611	Belongs to the LOG family
A8L58_00750	COG0297	glycogen (starch) synthase activity
A8L58_00755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A8L58_00780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8L58_00785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8L58_00820	COG0006	proline dipeptidase activity
A8L58_00835	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A8L58_00840	COG0531	amino acid
A8L58_00860	COG0598	Magnesium transport protein CorA
A8L58_00885	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A8L58_00895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A8L58_00910	COG3093	addiction module antidote protein HigA
A8L58_00920	COG0174	glutamine synthetase
A8L58_00940	COG0586	Pfam SNARE associated Golgi protein
A8L58_00945	COG2239	Acts as a magnesium transporter
A8L58_00950	COG0488	(ABC) transporter
A8L58_00960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A8L58_00975	COG0321	lipoyl(octanoyl) transferase activity
A8L58_00980	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8L58_01020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A8L58_01025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8L58_01045	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A8L58_01050	COG0723	plastoquinol--plastocyanin reductase activity
A8L58_01055	COG2010	Cytochrome c
A8L58_01060	COG1845	cytochrome c oxidase, subunit III
A8L58_01070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8L58_01115	COG1940	carbohydrate kinase activity
A8L58_01135	COG2197	response regulator
A8L58_01140	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A8L58_01155	COG2815	serine threonine protein kinase
A8L58_01155	COG0515	serine threonine protein kinase
A8L58_01165	COG0352	thiamine-phosphate diphosphorylase activity
A8L58_01175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A8L58_01180	COG0210	DNA helicase
A8L58_01200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8L58_01200	COG1116	anion transmembrane transporter activity
A8L58_01205	COG0596	Alpha beta hydrolase
A8L58_01215	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A8L58_01225	COG3265	gluconokinase activity
A8L58_01245	COG1131	(ABC) transporter
A8L58_01250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8L58_01250	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A8L58_01255	COG0509	glycine decarboxylation via glycine cleavage system
A8L58_01260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8L58_01280	COG0714	Associated with various cellular activities
A8L58_01285	COG2001	Belongs to the MraZ family
A8L58_01290	COG0275	rRNA processing
A8L58_01300	COG0768	penicillin binding
A8L58_01310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A8L58_01315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8L58_01320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A8L58_01325	COG0772	Belongs to the SEDS family
A8L58_01330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8L58_01335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8L58_01345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A8L58_01355	COG1799	cell septum assembly
A8L58_01370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A8L58_01385	COG0469	pyruvate kinase activity
A8L58_01400	COG2050	protein possibly involved in aromatic compounds catabolism
A8L58_01425	COG0539	negative regulation of cytoplasmic translation
A8L58_01430	COG0237	dephospho-CoA kinase activity
A8L58_01440	COG0556	nucleotide-excision repair
A8L58_01455	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8L58_01475	COG0322	excinuclease ABC activity
A8L58_01480	COG1660	Displays ATPase and GTPase activities
A8L58_01485	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A8L58_01490	COG1481	regulation of sporulation
A8L58_01495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A8L58_01500	COG0126	phosphoglycerate kinase activity
A8L58_01505	COG0149	triose-phosphate isomerase activity
A8L58_01510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8L58_01520	COG0285	dihydrofolate synthase activity
A8L58_01530	COG0105	UTP biosynthetic process
A8L58_01540	COG1472	Belongs to the glycosyl hydrolase 3 family
A8L58_01550	COG1530	ribonuclease E activity
A8L58_01555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A8L58_01560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A8L58_01570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A8L58_01575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A8L58_01580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A8L58_01585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A8L58_01700	COG1196	nuclear chromosome segregation
A8L58_01700	COG0741	lytic transglycosylase activity
A8L58_01700	COG0739	heme binding
A8L58_01765	COG0732	type I restriction modification DNA specificity domain
A8L58_01790	COG4974	Belongs to the 'phage' integrase family
A8L58_01840	COG2801	Transposase and inactivated derivatives
A8L58_01845	COG2963	transposase activity
A8L58_01855	COG1309	transcriptional regulator
A8L58_01865	COG2130	NADP-dependent
A8L58_01870	COG2801	Transposase and inactivated derivatives
A8L58_01930	COG1280	lysine exporter protein (LysE YggA)
A8L58_01935	COG1522	sequence-specific DNA binding
A8L58_01970	COG0488	(ABC) transporter
A8L58_02045	COG0590	tRNA wobble adenosine to inosine editing
A8L58_02050	COG1063	alcohol dehydrogenase
A8L58_02055	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A8L58_02070	COG0495	leucyl-tRNA aminoacylation
A8L58_02080	COG2333	competence protein COMEC
A8L58_02080	COG0658	competence protein
A8L58_02085	COG1061	Type III restriction enzyme res subunit
A8L58_02095	COG0268	Binds directly to 16S ribosomal RNA
A8L58_02105	COG0481	GTPase activity
A8L58_02125	COG4948	Mandelate Racemase Muconate Lactonizing
A8L58_02130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A8L58_02135	COG1169	isochorismate synthase
A8L58_02145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A8L58_02155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8L58_02160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8L58_02170	COG1131	(ABC) transporter
A8L58_02175	COG1309	transcriptional regulator
A8L58_02180	COG0477	Major facilitator Superfamily
A8L58_02190	COG0395	ABC-type sugar transport system, permease component
A8L58_02195	COG1175	transmembrane transport
A8L58_02215	COG0483	inositol monophosphate 1-phosphatase activity
A8L58_02235	COG1420	regulation of RNA biosynthetic process
A8L58_02240	COG0484	heat shock protein binding
A8L58_02250	COG1063	alcohol dehydrogenase
A8L58_02255	COG2213	PTS system mannitol-specific
A8L58_02255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8L58_02270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A8L58_02275	COG5006	permease, DMT superfamily
A8L58_02280	COG0343	queuine tRNA-ribosyltransferase activity
A8L58_02290	COG2197	response regulator
A8L58_02295	COG4152	abc transporter atp-binding protein
A8L58_02320	COG0596	Alpha beta hydrolase
A8L58_02335	COG2226	methyltransferase
A8L58_02355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A8L58_02365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A8L58_02375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8L58_02380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8L58_02385	COG0765	amino acid transport
A8L58_02390	COG0765	amino acid transport
A8L58_02400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A8L58_02410	COG1404	Belongs to the peptidase S8 family
A8L58_02415	COG1381	Involved in DNA repair and RecF pathway recombination
A8L58_02425	COG4716	Myosin-crossreactive antigen
A8L58_02450	COG0647	UMP catabolic process
A8L58_02455	COG1268	BioY protein
A8L58_02460	COG1122	ATPase activity
A8L58_02475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A8L58_02480	COG0497	DNA recombination
A8L58_02520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8L58_02540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8L58_02560	COG0107	imidazoleglycerol-phosphate synthase activity
A8L58_02565	COG0537	adenosine 5'-monophosphoramidase activity
A8L58_02575	COG0440	acetolactate synthase activity
A8L58_02580	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A8L58_02600	COG0473	3-isopropylmalate dehydrogenase activity
A8L58_02605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8L58_02610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8L58_02620	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8L58_02640	COG1414	Transcriptional regulator
A8L58_02645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A8L58_02650	COG0066	3-isopropylmalate dehydratase activity
A8L58_02660	COG1181	Belongs to the D-alanine--D-alanine ligase family
A8L58_02675	COG1674	ftsk spoiiie
A8L58_02685	COG3152	Membrane
A8L58_02700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A8L58_02705	COG2884	Cell division ATP-binding protein ftsE
A8L58_02710	COG2177	Part of the ABC transporter FtsEX involved in
A8L58_02715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A8L58_02720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A8L58_02730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A8L58_02740	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A8L58_02745	COG0165	Argininosuccinate lyase
A8L58_02760	COG1678	Uncharacterized ACR, COG1678
A8L58_02765	COG0745	RESPONSE REGULATOR receiver
A8L58_02770	COG5002	protein histidine kinase activity
A8L58_02775	COG5401	PFAM Sporulation and spore germination
A8L58_02785	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A8L58_02795	COG0653	protein targeting
A8L58_02815	COG0613	PHP domain protein
A8L58_02825	COG0180	Tryptophanyl-tRNA synthetase
A8L58_02850	COG1278	Cold shock
A8L58_02855	COG0210	DNA helicase
A8L58_02870	COG1074	ATP-dependent DNA helicase activity
A8L58_02875	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A8L58_02900	COG3480	Lon protease (S16) C-terminal proteolytic domain
A8L58_02910	COG1615	UPF0182 protein
A8L58_02940	COG0747	negative chemotaxis
A8L58_02965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8L58_02970	COG0483	inositol monophosphate 1-phosphatase activity
A8L58_02980	COG1162	GTPase activity
A8L58_02985	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A8L58_02995	COG1595	DNA-templated transcription, initiation
A8L58_03020	COG0567	Dehydrogenase, E1 component
A8L58_03020	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8L58_03030	COG1611	Belongs to the LOG family
A8L58_03040	COG0019	diaminopimelate decarboxylase activity
A8L58_03045	COG0460	homoserine dehydrogenase
A8L58_03050	COG0083	homoserine kinase activity
A8L58_03060	COG0254	rRNA binding
A8L58_03065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A8L58_03070	COG2890	protein-(glutamine-N5) methyltransferase activity
A8L58_03150	COG0318	PFAM AMP-dependent synthetase and ligase
A8L58_03160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A8L58_03165	COG0367	asparagine synthase
A8L58_03175	COG1045	serine acetyltransferase
A8L58_03190	COG0356	it plays a direct role in the translocation of protons across the membrane
A8L58_03195	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8L58_03200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A8L58_03205	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8L58_03210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A8L58_03215	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A8L58_03220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A8L58_03225	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A8L58_03280	COG0033	Phosphoglucomutase
A8L58_03290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8L58_03305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A8L58_03310	COG3281	Trehalose synthase
A8L58_03315	COG0366	Alpha amylase catalytic
A8L58_03335	COG0482	sulfurtransferase activity
A8L58_03350	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A8L58_03360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8L58_03375	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8L58_03380	COG0154	amidase activity
A8L58_03385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8L58_03390	COG2233	PERMEase
A8L58_03405	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A8L58_03410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A8L58_03425	COG0134	indole-3-glycerol-phosphate synthase activity
A8L58_03435	COG0159	tryptophan synthase activity
A8L58_03440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A8L58_03445	COG0070	glutamate synthase
A8L58_03445	COG0067	glutamate synthase
A8L58_03445	COG0069	glutamate synthase activity
A8L58_03465	COG0395	ABC-type sugar transport system, permease component
A8L58_03500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A8L58_03505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8L58_03510	COG0131	Imidazoleglycerol-phosphate dehydratase
A8L58_03515	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A8L58_03520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A8L58_03525	COG0217	transcriptional regulatory protein
A8L58_03530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A8L58_03535	COG0632	four-way junction helicase activity
A8L58_03540	COG2255	four-way junction helicase activity
A8L58_03550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8L58_03555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8L58_03560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8L58_03570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8L58_03575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A8L58_03585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8L58_03590	COG0124	histidyl-tRNA synthetase
A8L58_03600	COG1309	transcriptional regulator
A8L58_03615	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A8L58_03650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A8L58_03655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A8L58_03660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8L58_03665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8L58_03670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A8L58_03675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A8L58_03680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A8L58_03690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A8L58_03695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8L58_03705	COG0194	GDP metabolic process
A8L58_03710	COG1758	RNA polymerase activity
A8L58_03720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A8L58_03725	COG1201	RNA secondary structure unwinding
A8L58_03730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8L58_03760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A8L58_03770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A8L58_03780	COG1410	methionine synthase
A8L58_03780	COG0646	methionine synthase
A8L58_03795	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A8L58_03800	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A8L58_03810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A8L58_03815	COG1160	GTP binding
A8L58_03825	COG1764	response to oxidative stress
A8L58_03850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A8L58_03945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A8L58_03955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8L58_03975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8L58_03985	COG0277	FAD linked oxidase domain protein
A8L58_04045	COG3550	peptidyl-serine autophosphorylation
A8L58_04075	COG2807	transmembrane transport
A8L58_04095	COG0427	acetyl-CoA hydrolase
A8L58_04100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8L58_04105	COG2813	Specifically methylates the guanine in position
A8L58_04105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8L58_04110	COG1522	sequence-specific DNA binding
A8L58_04115	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A8L58_04120	COG1216	Glycosyl transferase, family 2
A8L58_04135	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A8L58_04140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8L58_04150	COG1966	Carbon starvation protein
A8L58_04165	COG0531	amino acid
A8L58_04215	COG1739	Uncharacterized protein family UPF0029
A8L58_04220	COG1472	Belongs to the glycosyl hydrolase 3 family
A8L58_04225	COG1597	lipid kinase activity
A8L58_04230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A8L58_04235	COG0009	L-threonylcarbamoyladenylate synthase
A8L58_04245	COG0205	6-phosphofructokinase activity
A8L58_04250	COG1295	ribonuclease BN
A8L58_04270	COG1716	ATPase activity
A8L58_04300	COG0438	transferase activity, transferring glycosyl groups
A8L58_04305	COG1560	Kdo2-lipid A biosynthetic process
A8L58_04320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8L58_04325	COG1064	alcohol dehydrogenase
A8L58_04350	COG0726	polysaccharide deacetylase
A8L58_04380	COG2326	polyphosphate kinase activity
A8L58_04385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8L58_04400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A8L58_04405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A8L58_04410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8L58_04415	COG0531	amino acid
A8L58_04420	COG0569	domain protein
A8L58_04440	COG0756	dUTP diphosphatase activity
A8L58_04475	COG1297	OPT oligopeptide transporter protein
A8L58_04485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A8L58_04505	COG0187	DNA topoisomerase II activity
A8L58_04520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8L58_04530	COG1643	Atp-dependent helicase
A8L58_04550	COG0717	Belongs to the dCTP deaminase family
A8L58_04555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8L58_04575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A8L58_04580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A8L58_04585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A8L58_04900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8L58_04905	COG2017	converts alpha-aldose to the beta-anomer
A8L58_04910	COG1418	mRNA catabolic process
A8L58_04915	COG2137	regulation of response to DNA damage stimulus
A8L58_04930	COG1349	DNA-binding transcription factor activity
A8L58_04940	COG1058	Belongs to the CinA family
A8L58_04940	COG1546	Belongs to the CinA family
A8L58_04950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8L58_04980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A8L58_04985	COG0284	orotidine-5'-phosphate decarboxylase activity
A8L58_04990	COG0167	dihydroorotate dehydrogenase activity
A8L58_04995	COG0543	2 iron, 2 sulfur cluster binding
A8L58_05000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8L58_05005	COG0505	Belongs to the CarA family
A8L58_05010	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8L58_05025	COG0667	Aldo Keto reductase
A8L58_05035	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A8L58_05050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8L58_05060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8L58_05065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8L58_05090	COG2304	oxidoreductase activity
A8L58_05100	COG0714	Associated with various cellular activities
A8L58_05130	COG0477	Major facilitator Superfamily
A8L58_05135	COG1309	transcriptional regulator
A8L58_05140	COG0515	serine threonine protein kinase
A8L58_05150	COG0583	DNA-binding transcription factor activity
A8L58_05160	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A8L58_05170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8L58_05190	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A8L58_05215	COG1191	sigma factor activity
A8L58_05220	COG0358	DNA primase activity
A8L58_05225	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A8L58_05250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A8L58_05255	COG1053	succinate dehydrogenase
A8L58_05265	COG0076	glutamate decarboxylase activity
A8L58_05275	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A8L58_05280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A8L58_05290	COG0423	glycine-tRNA ligase activity
A8L58_05300	COG0735	belongs to the Fur family
A8L58_05335	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A8L58_05340	COG0140	phosphoribosyl-ATP diphosphatase activity
A8L58_05345	COG3201	nicotinamide mononucleotide transporter
A8L58_05355	COG0667	Aldo Keto reductase
A8L58_05365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8L58_05375	COG1609	Transcriptional regulator
A8L58_05380	COG2160	L-arabinose isomerase activity
A8L58_05410	COG0395	ABC-type sugar transport system, permease component
A8L58_05420	COG1609	Transcriptional regulator
A8L58_05425	COG0395	ABC-type sugar transport system, permease component
A8L58_05430	COG1175	transmembrane transport
A8L58_05455	COG0606	chelatase, subunit chli
A8L58_05460	COG0792	nuclease activity
A8L58_05470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A8L58_05475	COG0681	Belongs to the peptidase S26 family
A8L58_05480	COG0335	large ribosomal subunit rRNA binding
A8L58_05485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A8L58_05490	COG1053	succinate dehydrogenase
A8L58_05500	COG0336	Belongs to the RNA methyltransferase TrmD family
A8L58_05505	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A8L58_05510	COG1837	Belongs to the UPF0109 family
A8L58_05515	COG0228	four-way junction DNA binding
A8L58_05590	COG0656	L-ascorbic acid biosynthetic process
A8L58_05595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8L58_05600	COG0571	ribonuclease III activity
A8L58_05605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A8L58_05615	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A8L58_05620	COG0742	ribosomal rna small subunit methyltransferase
A8L58_05640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A8L58_05645	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A8L58_05655	COG0028	Belongs to the TPP enzyme family
A8L58_05665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A8L58_05670	COG1185	polyribonucleotide nucleotidyltransferase activity
A8L58_05675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A8L58_05695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A8L58_05715	COG3732	PTS system glucitol sorbitol-specific
A8L58_05730	COG0371	Dehydrogenase
A8L58_05735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A8L58_05745	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A8L58_05755	COG0195	Participates in both transcription termination and antitermination
A8L58_05760	COG0779	Required for maturation of 30S ribosomal subunits
A8L58_05780	COG0442	prolyl-tRNA aminoacylation
A8L58_05790	COG1305	Transglutaminase-like
A8L58_05820	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A8L58_05825	COG0750	zinc metalloprotease
A8L58_05835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8L58_05840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A8L58_05845	COG0575	Belongs to the CDS family
A8L58_05850	COG0233	cytoplasmic translational termination
A8L58_05855	COG0528	UMP kinase activity
A8L58_05860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A8L58_05865	COG0052	Belongs to the universal ribosomal protein uS2 family
A8L58_05870	COG3831	ATPase activity
A8L58_05885	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A8L58_05900	COG4974	Belongs to the 'phage' integrase family
A8L58_05910	COG0242	peptide deformylase activity
A8L58_05950	COG1119	ATPase activity
A8L58_05955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A8L58_05980	COG1028	Short-chain dehydrogenase reductase Sdr
A8L58_06010	COG0488	(ABC) transporter
A8L58_06025	COG0110	maltose O-acetyltransferase activity
A8L58_06060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8L58_06065	COG0396	ATPase activity
A8L58_06080	COG0719	Fe-S assembly protein
A8L58_06095	COG1175	transmembrane transport
A8L58_06100	COG3833	ABC-type maltose transport systems, permease component
A8L58_06105	COG1609	Transcriptional regulator
A8L58_06110	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A8L58_06115	COG1131	(ABC) transporter
A8L58_06125	COG1612	heme a metabolic process
A8L58_06130	COG0109	protoheme IX farnesyltransferase activity
A8L58_06145	COG0363	glucosamine-6-phosphate deaminase activity
A8L58_06155	COG0525	valine-tRNA ligase activity
A8L58_06170	COG4946	Tricorn protease homolog
A8L58_06170	COG0793	Belongs to the peptidase S41A family
A8L58_06180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A8L58_06185	COG0740	serine-type endopeptidase activity
A8L58_06190	COG0740	serine-type endopeptidase activity
A8L58_06200	COG0544	peptidyl-prolyl cis-trans isomerase activity
A8L58_06220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A8L58_06220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A8L58_06240	COG0698	ribose 5-phosphate isomerase
A8L58_06255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8L58_06260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A8L58_06275	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A8L58_06285	COG2814	Major facilitator Superfamily
A8L58_06300	COG1022	Amp-dependent synthetase and ligase
A8L58_06315	COG0247	lactate metabolic process
A8L58_06315	COG0277	FAD linked oxidase domain protein
A8L58_06340	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A8L58_06350	COG4106	trans-aconitate 2-methyltransferase activity
A8L58_06360	COG0519	Catalyzes the synthesis of GMP from XMP
A8L58_06365	COG1794	racemase activity, acting on amino acids and derivatives
A8L58_06385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8L58_06395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A8L58_06400	COG2197	response regulator
A8L58_06405	COG4585	Histidine kinase
A8L58_06415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8L58_06425	COG1113	amino acid transport
A8L58_06440	COG1131	(ABC) transporter
A8L58_06460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8L58_06465	COG0531	amino acid
A8L58_06475	COG0587	DNA-directed DNA polymerase activity
A8L58_06490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8L58_06515	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A8L58_06540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8L58_06550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A8L58_06555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A8L58_06560	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A8L58_06565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A8L58_06575	COG1918	ferrous iron import across plasma membrane
A8L58_06575	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A8L58_06590	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A8L58_06670	COG0662	Cupin 2, conserved barrel domain protein
A8L58_06670	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A8L58_06685	COG1316	TRANSCRIPTIONal
A8L58_06705	COG3340	Belongs to the peptidase S51 family
A8L58_06715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8L58_06725	COG0424	maF-like protein
A8L58_06740	COG4221	oxidoreductase activity
A8L58_06750	COG0351	phosphomethylpyrimidine kinase
A8L58_06760	COG4770	biotin carboxylase activity
A8L58_06780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8L58_06795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8L58_06800	COG4656	Part of a membrane complex involved in electron transport
A8L58_06805	COG5275	peptidyl-tyrosine sulfation
A8L58_06805	COG0252	asparaginase activity
A8L58_06815	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A8L58_06835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8L58_06875	COG1253	flavin adenine dinucleotide binding
A8L58_06895	COG0039	L-malate dehydrogenase activity
A8L58_06910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8L58_06920	COG0138	bifunctional purine biosynthesis protein purh
A8L58_06930	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A8L58_06935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8L58_06935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8L58_06965	COG0045	succinate-CoA ligase (ADP-forming) activity
A8L58_06985	COG1464	Belongs to the NlpA lipoprotein family
A8L58_06990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8L58_06995	COG2011	ABC-type metal ion transport system permease component
A8L58_07005	COG2261	transglycosylase associated protein
A8L58_07010	COG2197	response regulator
A8L58_07035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8L58_07035	COG0519	Catalyzes the synthesis of GMP from XMP
A8L58_07040	COG1045	serine acetyltransferase
A8L58_07045	COG0287	Prephenate dehydrogenase
A8L58_07045	COG1605	Chorismate mutase
A8L58_07065	COG0459	protein refolding
A8L58_07070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A8L58_07090	COG1355	regulation of microtubule-based process
A8L58_07110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A8L58_07120	COG0456	acetyltransferase
A8L58_07120	COG1214	PFAM Peptidase M22, glycoprotease
A8L58_07125	COG0802	atpase or kinase
A8L58_07130	COG0513	Belongs to the DEAD box helicase family
A8L58_07145	COG0736	holo-[acyl-carrier-protein] synthase activity
A8L58_07150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A8L58_07160	COG1072	(Pantothenic acid kinase))
A8L58_07170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8L58_07180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A8L58_07185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A8L58_07205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A8L58_07210	COG0101	tRNA pseudouridine synthase activity
A8L58_07225	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A8L58_07230	COG3845	ABC transporter
A8L58_07245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8L58_07245	COG0519	Catalyzes the synthesis of GMP from XMP
A8L58_07255	COG0438	transferase activity, transferring glycosyl groups
A8L58_07260	COG0203	ribosomal protein L17
A8L58_07265	COG0202	RNA polymerase activity
A8L58_07270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A8L58_07275	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A8L58_07280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A8L58_07285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A8L58_07290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A8L58_07310	COG0563	adenylate kinase activity
A8L58_07345	COG0200	Binds to the 23S rRNA
A8L58_07350	COG1841	ribosomal large subunit assembly
A8L58_07355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A8L58_07360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A8L58_07365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A8L58_07370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A8L58_07375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A8L58_07380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A8L58_07385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A8L58_07395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8L58_07400	COG0395	ABC-type sugar transport system, permease component
A8L58_07405	COG1175	transmembrane transport
A8L58_07425	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A8L58_07430	COG0255	Belongs to the universal ribosomal protein uL29 family
A8L58_07435	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A8L58_07440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A8L58_07445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A8L58_07450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A8L58_07455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A8L58_07460	COG0089	rRNA binding
A8L58_07465	COG0088	Forms part of the polypeptide exit tunnel
A8L58_07470	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A8L58_07475	COG0051	transcription antitermination factor activity, RNA binding
A8L58_07480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8L58_07485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8L58_07500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A8L58_07505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8L58_07510	COG0049	tRNA binding
A8L58_07515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A8L58_07520	COG0673	inositol 2-dehydrogenase activity
A8L58_07535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A8L58_07540	COG0085	RNA polymerase activity
A8L58_07545	COG0222	ribosome binding
A8L58_07555	COG0081	regulation of translation
A8L58_07560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A8L58_07565	COG0250	Participates in transcription elongation, termination and antitermination
A8L58_07580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8L58_07585	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A8L58_07595	COG2030	dehydratase
A8L58_07600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8L58_07640	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8L58_07645	COG0649	NAD binding
A8L58_07645	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8L58_07650	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8L58_07655	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A8L58_07655	COG0674	pyruvate-flavodoxin oxidoreductase activity
A8L58_07660	COG1013	pyruvate-flavodoxin oxidoreductase activity
A8L58_07665	COG3590	peptidase
A8L58_07720	COG1007	ATP synthesis coupled electron transport
A8L58_07735	COG0713	ATP synthesis coupled electron transport
A8L58_07745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8L58_07750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A8L58_07755	COG1034	ATP synthesis coupled electron transport
A8L58_07760	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A8L58_07770	COG0649	NAD binding
A8L58_07775	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8L58_07780	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8L58_07790	COG0644	oxidoreductase
A8L58_07815	COG1131	(ABC) transporter
A8L58_07820	COG2226	methyltransferase
A8L58_07830	COG1132	(ABC) transporter
A8L58_07850	COG2376	Dihydroxyacetone kinase
A8L58_07855	COG1461	Dihydroxyacetone kinase
A8L58_07860	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A8L58_07860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8L58_07860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8L58_07880	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A8L58_07900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8L58_07910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8L58_07955	COG3848	Pyruvate phosphate dikinase
A8L58_07955	COG0574	Belongs to the PEP-utilizing enzyme family
A8L58_07970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8L58_08085	COG0395	ABC-type sugar transport system, permease component
A8L58_08110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A8L58_08150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8L58_08165	COG0252	asparaginase activity
A8L58_08170	COG1113	amino acid transport
A8L58_08180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8L58_08185	COG0047	phosphoribosylformylglycinamidine synthase activity
A8L58_08190	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A8L58_08195	COG0450	alkyl hydroperoxide reductase
A8L58_08200	COG3634	alkyl hydroperoxide reductase activity
A8L58_08210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A8L58_08215	COG0151	Belongs to the GarS family
A8L58_08220	COG4423	Transcription factor
A8L58_08225	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
A8L58_08230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A8L58_08245	COG1937	Protein conserved in bacteria
A8L58_08250	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8L58_08265	COG2337	Toxic component of a toxin-antitoxin (TA) module
A8L58_08280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8L58_08290	COG3485	protocatechuate 3,4-dioxygenase
A8L58_08295	COG1490	D-aminoacyl-tRNA deacylase activity
A8L58_08325	COG0745	RESPONSE REGULATOR receiver
A8L58_08330	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A8L58_08355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A8L58_08360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A8L58_08370	COG0254	rRNA binding
A8L58_08375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8L58_08385	COG0523	cobalamin synthesis protein
A8L58_08400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8L58_08405	COG1121	(ABC) transporter
A8L58_08415	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8L58_08420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8L58_08425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8L58_08430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8L58_08435	COG1120	ATPase activity
A8L58_08455	COG0129	dihydroxy-acid dehydratase activity
A8L58_08460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8L58_08475	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A8L58_08495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8L58_08505	COG0785	Cytochrome C biogenesis protein
A8L58_08510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8L58_08515	COG0406	alpha-ribazole phosphatase activity
A8L58_08520	COG1648	precorrin-2 dehydrogenase activity
A8L58_08520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8L58_08525	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A8L58_08550	COG0506	proline dehydrogenase activity
A8L58_08555	COG1082	Xylose isomerase domain protein TIM barrel
A8L58_08570	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A8L58_08575	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
A8L58_08590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A8L58_08595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A8L58_08605	COG0181	hydroxymethylbilane synthase activity
A8L58_08615	COG0113	porphobilinogen synthase activity
A8L58_08620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A8L58_08635	COG3842	ATPase activity
A8L58_08645	COG4143	(ABC) transporter
A8L58_08655	COG0705	Rhomboid family
A8L58_08655	COG0457	Tetratricopeptide repeat
A8L58_08710	COG0542	response to heat
A8L58_08720	COG0649	NAD binding
A8L58_08735	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A8L58_08740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A8L58_08745	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A8L58_08750	COG0302	gtp cyclohydrolase
A8L58_08765	COG0037	tRNA processing
A8L58_08775	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A8L58_08785	COG3458	cephalosporin-C deacetylase activity
A8L58_08790	COG2062	phosphohistidine phosphatase, SixA
A8L58_08835	COG1522	sequence-specific DNA binding
A8L58_08840	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8L58_08845	COG4172	Belongs to the ABC transporter superfamily
A8L58_08850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8L58_08855	COG0601	transmembrane transport
A8L58_08880	COG0431	NADPH-dependent FMN reductase
A8L58_08885	COG1231	oxidoreductase activity
A8L58_08925	COG1774	PSP1 C-terminal conserved region
A8L58_08935	COG0470	DNA polymerase III
A8L58_08940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A8L58_08950	COG1754	DNA topoisomerase type I activity
A8L58_08950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A8L58_08960	COG2890	protein-(glutamine-N5) methyltransferase activity
A8L58_08965	COG1205	dead DEAH box helicase
A8L58_08965	COG1111	helicase
A8L58_09055	COG0494	nUDIX hydrolase
A8L58_09085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8L58_09090	COG1408	metallophosphoesterase
A8L58_09115	COG2040	homocysteine
A8L58_09120	COG1846	Transcriptional regulator
A8L58_09150	COG0601	transmembrane transport
A8L58_09155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8L58_09160	COG0444	Belongs to the ABC transporter superfamily
A8L58_09165	COG4608	Belongs to the ABC transporter superfamily
A8L58_09180	COG3022	response to hydroperoxide
A8L58_09195	COG1069	ribulokinase activity
A8L58_09200	COG1072	(Pantothenic acid kinase))
A8L58_09220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A8L58_09230	COG0534	Mate efflux family protein
A8L58_09235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8L58_09270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A8L58_09270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8L58_09280	COG2197	response regulator
A8L58_09305	COG1793	dna ligase
A8L58_09305	COG3285	dna ligase
A8L58_09310	COG2124	cytochrome p450
A8L58_09315	COG1028	Short-chain dehydrogenase reductase Sdr
A8L58_09325	COG0783	Belongs to the Dps family
A8L58_09330	COG1028	Short-chain dehydrogenase reductase Sdr
A8L58_09345	COG1295	ribonuclease BN
A8L58_09365	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A8L58_09385	COG4572	Cation transport regulator
A8L58_09390	COG0667	Aldo Keto reductase
A8L58_09405	COG3158	transport of potassium into the cell
A8L58_09430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A8L58_09455	COG1468	defense response to virus
A8L58_09455	COG1518	maintenance of DNA repeat elements
A8L58_09480	COG1609	Transcriptional regulator
A8L58_09505	COG1653	transport
A8L58_09510	COG1175	transmembrane transport
A8L58_09515	COG0395	ABC-type sugar transport system, permease component
A8L58_09540	COG3340	Belongs to the peptidase S51 family
A8L58_09550	COG0402	S-adenosylhomocysteine deaminase activity
A8L58_09565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8L58_09575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8L58_09585	COG0183	Belongs to the thiolase family
A8L58_09600	COG0586	Pfam SNARE associated Golgi protein
A8L58_09610	COG0438	transferase activity, transferring glycosyl groups
A8L58_09620	COG0745	RESPONSE REGULATOR receiver
A8L58_09625	COG1968	undecaprenyl-diphosphatase activity
A8L58_09635	COG0390	transport system, permease component
A8L58_09645	COG1064	alcohol dehydrogenase
A8L58_09655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A8L58_09660	COG1063	alcohol dehydrogenase
A8L58_09665	COG2376	Dihydroxyacetone kinase
A8L58_09670	COG1946	Acyl-CoA thioesterase
A8L58_09680	COG0673	inositol 2-dehydrogenase activity
A8L58_09685	COG1942	4-Oxalocrotonate Tautomerase
A8L58_09705	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A8L58_09715	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A8L58_09735	COG0433	COG0433 Predicted ATPase
A8L58_09750	COG3263	regulation of cellular component size
A8L58_09755	COG0517	IMP dehydrogenase activity
A8L58_09755	COG1125	glycine betaine transport
A8L58_09765	COG1174	glycine betaine transport
A8L58_09775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8L58_09810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A8L58_09835	COG2130	NADP-dependent
A8L58_09840	COG4946	Tricorn protease homolog
A8L58_09840	COG1506	peptidase
A8L58_09840	COG0823	Involved in the tonB-independent uptake of proteins
A8L58_09845	COG0584	glycerophosphoryl diester phosphodiesterase
A8L58_09870	COG1316	TRANSCRIPTIONal
A8L58_09875	COG1609	Transcriptional regulator
A8L58_09880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A8L58_09905	COG0604	alcohol dehydrogenase
A8L58_09905	COG3321	synthase
A8L58_09905	COG1028	Short-chain dehydrogenase reductase Sdr
A8L58_09910	COG0137	argininosuccinate synthase activity
A8L58_09930	COG0561	phosphatase activity
A8L58_09935	COG1609	Transcriptional regulator
A8L58_09950	COG3833	ABC-type maltose transport systems, permease component
A8L58_09970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A8L58_09990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A8L58_10000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8L58_10010	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8L58_10015	COG0022	dehydrogenase e1 component
A8L58_10025	COG1233	COG1233 Phytoene dehydrogenase and related
A8L58_10050	COG0477	Major facilitator Superfamily
A8L58_10060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8L58_10065	COG0006	proline dipeptidase activity
A8L58_10105	COG0154	amidase activity
A8L58_10110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8L58_10130	COG1126	abc transporter atp-binding protein
A8L58_10135	COG0765	amino acid transport
A8L58_10140	COG0765	amino acid transport
A8L58_10185	COG1715	Restriction endonuclease
A8L58_10205	COG3976	FMN-binding domain protein
A8L58_10205	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A8L58_10215	COG5002	protein histidine kinase activity
A8L58_10230	COG1621	beta-fructofuranosidase activity
A8L58_10235	COG0477	Major facilitator Superfamily
A8L58_10290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A8L58_10300	COG0366	Alpha amylase catalytic
A8L58_10340	COG1653	transport
A8L58_10345	COG0395	ABC-type sugar transport system, permease component
A8L58_10350	COG1175	transmembrane transport
A8L58_10355	COG1285	pathogenesis
A8L58_10375	COG1940	carbohydrate kinase activity
A8L58_10390	COG0395	ABC-type sugar transport system, permease component
A8L58_10395	COG0366	Alpha amylase catalytic
A8L58_10410	COG1132	(ABC) transporter
A8L58_10415	COG1132	(ABC) transporter
A8L58_10430	COG2423	ornithine cyclodeaminase activity
A8L58_10450	COG0395	ABC-type sugar transport system, permease component
A8L58_10455	COG1175	transmembrane transport
A8L58_10465	COG1609	Transcriptional regulator
A8L58_10480	COG2205	protein histidine kinase activity
A8L58_10490	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A8L58_10525	COG1968	undecaprenyl-diphosphatase activity
A8L58_10535	COG0359	binds to the 23S rRNA
A8L58_10540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A8L58_10550	COG0360	Binds together with S18 to 16S ribosomal RNA
A8L58_10555	COG2837	iron assimilation
A8L58_10565	COG0672	)-iron permease
A8L58_10575	COG1022	Amp-dependent synthetase and ligase
A8L58_10590	COG0300	oxidoreductase activity
A8L58_10635	COG0277	FAD linked oxidase domain protein
A8L58_10640	COG4585	Histidine kinase
A8L58_10645	COG0247	lactate metabolic process
A8L58_10650	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A8L58_10655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A8L58_10660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8L58_10665	COG1846	Transcriptional regulator
A8L58_10675	COG1113	amino acid transport
A8L58_10790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8L58_10800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A8L58_10810	COG1175	transmembrane transport
A8L58_10835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8L58_10840	COG1733	regulation of RNA biosynthetic process
A8L58_10865	COG2337	Toxic component of a toxin-antitoxin (TA) module
A8L58_10870	COG3609	addiction module antidote protein, CC2985 family
A8L58_10880	COG2146	nitrite reductase [NAD(P)H] activity
A8L58_10885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8L58_10890	COG0842	Transport permease protein
A8L58_10890	COG1131	(ABC) transporter
A8L58_10890	COG1716	ATPase activity
A8L58_10895	COG0515	serine threonine protein kinase
A8L58_10905	COG0205	6-phosphofructokinase activity
A8L58_10910	COG0686	Belongs to the AlaDH PNT family
A8L58_10915	COG2267	carboxylic ester hydrolase activity
A8L58_10960	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A8L58_10970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A8L58_11010	COG0038	chloride channel
A8L58_11020	COG2848	UPF0210 protein
A8L58_11025	COG3830	Belongs to the UPF0237 family
A8L58_11035	COG0114	fumarate hydratase activity
A8L58_11040	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A8L58_11075	COG2814	Major facilitator Superfamily
A8L58_11085	COG1349	DNA-binding transcription factor activity
A8L58_11090	COG0540	Belongs to the ATCase OTCase family
A8L58_11105	COG0668	transmembrane transport
A8L58_11115	COG1929	Belongs to the glycerate kinase type-1 family
A8L58_11130	COG1012	belongs to the aldehyde dehydrogenase family
A8L58_11135	COG0385	Bile acid
A8L58_11170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8L58_11175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8L58_11180	COG2390	Transcriptional regulator
A8L58_11190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8L58_11205	COG0395	ABC-type sugar transport system, permease component
A8L58_11225	COG1609	Transcriptional regulator
A8L58_11235	COG1733	regulation of RNA biosynthetic process
A8L58_11245	COG0564	pseudouridine synthase activity
A8L58_11320	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A8L58_11370	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A8L58_11385	COG2124	cytochrome p450
A8L58_11395	COG0626	cystathionine gamma-synthase activity
A8L58_11410	COG1660	Displays ATPase and GTPase activities
A8L58_11430	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A8L58_11430	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A8L58_11445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A8L58_11455	COG1082	Xylose isomerase domain protein TIM barrel
A8L58_11460	COG0673	inositol 2-dehydrogenase activity
A8L58_11465	COG1609	Transcriptional regulator
A8L58_11475	COG2855	membrane
A8L58_11480	COG1082	Xylose isomerase domain protein TIM barrel
A8L58_11485	COG0673	inositol 2-dehydrogenase activity
A8L58_11495	COG0673	inositol 2-dehydrogenase activity
A8L58_11500	COG2814	Major facilitator Superfamily
A8L58_11510	COG2814	Major facilitator Superfamily
A8L58_11520	COG1082	Xylose isomerase domain protein TIM barrel
A8L58_11525	COG0673	inositol 2-dehydrogenase activity
A8L58_11530	COG1082	Xylose isomerase domain protein TIM barrel
A8L58_11550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8L58_11555	COG1181	Belongs to the D-alanine--D-alanine ligase family
A8L58_11570	COG3285	dna ligase
A8L58_11570	COG1793	dna ligase
A8L58_11580	COG1192	Involved in chromosome partitioning
A8L58_11590	COG0357	Ribosomal RNA small subunit methyltransferase G
A8L58_11595	COG2076	Multidrug Resistance protein
A8L58_11605	COG0706	membrane insertase activity
A8L58_11615	COG0594	ribonuclease P activity
A8L58_11620	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A8L58_11625	COG1136	(ABC) transporter
A8L58_11625	COG0577	efflux transmembrane transporter activity
A8L58_11630	COG0577	efflux transmembrane transporter activity
A8L58_11630	COG1136	(ABC) transporter
A8L58_11635	COG0592	DNA-directed DNA polymerase activity
A8L58_11645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A8L58_11650	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
A8L58_11660	COG0187	DNA topoisomerase II activity
A8L58_11665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A8L58_11670	COG3266	domain, Protein
A8L58_11680	COG1609	Transcriptional regulator
A8L58_11685	COG1129	ABC transporter
A8L58_11690	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8L58_11695	COG1879	ABC-type sugar transport system periplasmic component
A8L58_11700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8L58_11705	COG1869	D-ribose catabolic process
A8L58_11730	COG1028	Short-chain dehydrogenase reductase Sdr
A8L58_11740	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
A8L58_11745	COG1396	sequence-specific DNA binding
A8L58_11790	COG0039	L-malate dehydrogenase activity
A8L58_11805	COG0281	malic enzyme
A8L58_11810	COG0039	L-malate dehydrogenase activity
A8L58_11815	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A8L58_11825	COG1012	belongs to the aldehyde dehydrogenase family
A8L58_11830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A8L58_11850	COG0531	amino acid
A8L58_11860	COG0235	Class ii aldolase
A8L58_11870	COG1063	alcohol dehydrogenase
A8L58_11875	COG3414	Phosphotransferase system galactitol-specific IIB component
A8L58_11880	COG3775	system Galactitol-specific IIC component
A8L58_11890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8L58_11895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A8L58_11915	COG1131	(ABC) transporter
A8L58_11925	COG0095	Lipoate-protein ligase
A8L58_11930	COG0148	phosphopyruvate hydratase activity
A8L58_11935	COG0765	amino acid transport
A8L58_11940	COG1126	abc transporter atp-binding protein
A8L58_11945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8L58_11960	COG1175	transmembrane transport
A8L58_11970	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A8L58_11990	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A8L58_12055	COG1012	belongs to the aldehyde dehydrogenase family
A8L58_12065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A8L58_12095	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A8L58_12120	COG1136	(ABC) transporter
A8L58_12125	COG2197	response regulator
A8L58_12135	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A8L58_12140	COG3657	addiction module killer protein
A8L58_12145	COG1690	Belongs to the RtcB family
A8L58_12150	COG0477	Major facilitator Superfamily
A8L58_12155	COG1132	(ABC) transporter
A8L58_12195	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A8L58_12200	COG4585	Histidine kinase
A8L58_12210	COG5002	protein histidine kinase activity
A8L58_12215	COG0745	RESPONSE REGULATOR receiver
A8L58_12225	COG2132	Multicopper oxidase
A8L58_12250	COG0175	sulfate reduction
A8L58_12265	COG0730	response to heat
A8L58_12280	COG1473	amidohydrolase
A8L58_12290	COG0656	L-ascorbic acid biosynthetic process
A8L58_12325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A8L58_12340	COG2022	thiamine diphosphate biosynthetic process
A8L58_12360	COG1309	transcriptional regulator
A8L58_12365	COG2409	Drug exporters of the RND superfamily
A8L58_12375	COG0438	transferase activity, transferring glycosyl groups
A8L58_12385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8L58_12390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8L58_12400	COG2814	Major facilitator Superfamily
A8L58_12410	COG0477	Major facilitator Superfamily
A8L58_12415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A8L58_12420	COG1914	H( )-stimulated, divalent metal cation uptake system
A8L58_12425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8L58_12425	COG1321	iron dependent repressor
A8L58_12440	COG0281	malic enzyme
A8L58_12460	COG1254	Belongs to the acylphosphatase family
A8L58_12465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8L58_12465	COG0045	succinate-CoA ligase (ADP-forming) activity
A8L58_12465	COG1042	CoA-binding domain protein
A8L58_12470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8L58_12480	COG0511	ligase activity, forming carbon-carbon bonds
A8L58_12490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8L58_12500	COG1136	(ABC) transporter
A8L58_12500	COG0577	efflux transmembrane transporter activity
A8L58_12525	COG0205	6-phosphofructokinase activity
A8L58_12565	COG3189	MarR family transcriptional regulator
A8L58_12575	COG2217	Heavy metal translocating P-type atpase
A8L58_12585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8L58_12590	COG0783	Belongs to the Dps family
A8L58_12645	COG1484	DNA-dependent DNA replication
A8L58_12675	COG1484	DNA-dependent DNA replication
A8L58_12700	COG0456	acetyltransferase
A8L58_12710	COG4166	transmembrane transport
A8L58_12725	COG0601	transmembrane transport
A8L58_12755	COG2337	Toxic component of a toxin-antitoxin (TA) module
A8L58_12765	COG1151	hydroxylamine reductase activity
A8L58_12770	COG0543	2 iron, 2 sulfur cluster binding
A8L58_12770	COG0633	Ferredoxin
A8L58_12775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8L58_12795	COG1140	nitrate reductase beta subunit
A8L58_12815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A8L58_12825	COG0314	molybdopterin synthase activity
A8L58_12835	COG0315	cyclic pyranopterin monophosphate synthase activity
A8L58_12840	COG0521	Mo-molybdopterin cofactor biosynthetic process
A8L58_12840	COG0315	cyclic pyranopterin monophosphate synthase activity
A8L58_12845	COG2364	Membrane
A8L58_12850	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A8L58_12850	COG0352	thiamine-phosphate diphosphorylase activity
A8L58_12850	COG0351	phosphomethylpyrimidine kinase
A8L58_12855	COG0352	thiamine-phosphate diphosphorylase activity
A8L58_12860	COG3386	PFAM SMP-30 Gluconolaconase
A8L58_12880	COG1129	ABC transporter
A8L58_12920	COG1012	belongs to the aldehyde dehydrogenase family
A8L58_12930	COG1609	Transcriptional regulator
A8L58_12935	COG1904	glucuronate isomerase
A8L58_12940	COG0246	Mannitol dehydrogenase
A8L58_12945	COG1312	Catalyzes the dehydration of D-mannonate
A8L58_12955	COG0656	L-ascorbic acid biosynthetic process
A8L58_12965	COG4948	Mandelate Racemase Muconate Lactonizing
A8L58_12985	COG1285	pathogenesis
A8L58_12995	COG1609	Transcriptional regulator
A8L58_13000	COG0584	glycerophosphoryl diester phosphodiesterase
A8L58_13005	COG1653	transport
A8L58_13010	COG0395	ABC-type sugar transport system, permease component
A8L58_13060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8L58_13070	COG1482	cell wall glycoprotein biosynthetic process
A8L58_13075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8L58_13080	COG0800	Aldolase
A8L58_13090	COG1609	Transcriptional regulator
A8L58_13100	COG2721	sulfolactate sulfo-lyase activity
A8L58_13105	COG1904	glucuronate isomerase
A8L58_13180	COG2211	Major facilitator Superfamily
A8L58_13210	COG5564	TIM-barrel signal transduction protein
A8L58_13220	COG2186	Transcriptional regulator
A8L58_13230	COG0673	inositol 2-dehydrogenase activity
A8L58_13235	COG1609	Transcriptional regulator
A8L58_13240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A8L58_13260	COG1119	ATPase activity
A8L58_13270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8L58_13280	COG0586	Pfam SNARE associated Golgi protein
A8L58_13285	COG1063	alcohol dehydrogenase
A8L58_13300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A8L58_13330	COG1253	flavin adenine dinucleotide binding
A8L58_13360	COG2072	flavoprotein involved in K transport
A8L58_13445	COG0438	transferase activity, transferring glycosyl groups
A8L58_13450	COG0438	transferase activity, transferring glycosyl groups
A8L58_13490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A8L58_13520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8L58_13520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A8L58_13520	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A8L58_13525	COG1105	Belongs to the carbohydrate kinase PfkB family
A8L58_13535	COG0765	amino acid transport
A8L58_13540	COG0765	amino acid transport
A8L58_13545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8L58_13550	COG1126	abc transporter atp-binding protein
A8L58_13555	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A8L58_13565	COG0297	glycogen (starch) synthase activity
A8L58_13605	COG2897	thiosulfate sulfurtransferase activity
A8L58_13620	COG1643	Atp-dependent helicase
A8L58_13635	COG2094	Belongs to the DNA glycosylase MPG family
A8L58_13655	COG1846	Transcriptional regulator
A8L58_13660	COG0386	Belongs to the glutathione peroxidase family
A8L58_13670	COG3118	belongs to the thioredoxin family
A8L58_13675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8L58_13675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A8L58_13680	COG0305	Participates in initiation and elongation during chromosome replication
A8L58_13685	COG1937	Protein conserved in bacteria
A8L58_13700	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A8L58_13750	COG0489	protein tyrosine kinase activity
A8L58_13775	COG0438	transferase activity, transferring glycosyl groups
A8L58_13805	COG2089	acid synthase
A8L58_13810	COG1083	cytidylyl-transferase
A8L58_13820	COG0167	dihydroorotate dehydrogenase activity
A8L58_13825	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A8L58_13825	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A8L58_13825	COG1013	pyruvate-flavodoxin oxidoreductase activity
A8L58_13825	COG0674	pyruvate-flavodoxin oxidoreductase activity
A8L58_13840	COG2186	Transcriptional regulator
A8L58_13845	COG1620	l-lactate permease
A8L58_13850	COG0247	lactate metabolic process
A8L58_13855	COG1139	Iron-sulfur cluster binding protein
A8L58_13860	COG1556	Lactate utilization protein
A8L58_13870	COG1132	(ABC) transporter
A8L58_13875	COG4988	ABC transporter
A8L58_13880	COG1294	oxidase, subunit
A8L58_13885	COG1271	oxidase subunit
A8L58_13915	COG2814	Major facilitator Superfamily
A8L58_13920	COG1454	alcohol dehydrogenase
A8L58_13930	COG1653	transport
A8L58_13935	COG0395	ABC-type sugar transport system, permease component
A8L58_13945	COG1609	Transcriptional regulator
A8L58_13960	COG1309	transcriptional regulator
A8L58_13965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8L58_13990	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A8L58_13995	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A8L58_14000	COG2186	Transcriptional regulator
A8L58_14020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A8L58_14025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8L58_14030	COG1301	dicarboxylic acid transport
A8L58_14035	COG1953	Uracil, thiamine, allantoin
A8L58_14045	COG0393	Putative heavy-metal-binding
A8L58_14050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A8L58_14070	COG0515	serine threonine protein kinase
A8L58_14075	COG0768	penicillin binding
A8L58_14090	COG1716	ATPase activity
A8L58_14095	COG1716	ATPase activity
A8L58_14105	COG1088	dTDP-glucose 4,6-dehydratase activity
A8L58_14110	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A8L58_14125	COG0604	alcohol dehydrogenase
A8L58_14145	COG1316	TRANSCRIPTIONal
A8L58_14155	COG0489	protein tyrosine kinase activity
A8L58_14160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8L58_14170	COG0438	transferase activity, transferring glycosyl groups
A8L58_14180	COG1484	DNA-dependent DNA replication
A8L58_14230	COG0477	Major facilitator Superfamily
A8L58_14235	COG1695	Transcriptional regulator
A8L58_14240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A8L58_14250	COG1113	amino acid transport
A8L58_14255	COG1309	transcriptional regulator
A8L58_14260	COG1131	(ABC) transporter
A8L58_14305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A8L58_14310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A8L58_14335	COG0577	efflux transmembrane transporter activity
A8L58_14335	COG1136	(ABC) transporter
A8L58_14345	COG0561	phosphatase activity
A8L58_14350	COG0561	phosphatase activity
A8L58_14355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A8L58_14390	COG0861	Integral membrane protein TerC family
A8L58_14395	COG2814	Major facilitator Superfamily
A8L58_14400	COG0583	DNA-binding transcription factor activity
A8L58_14420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8L58_14425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8L58_14435	COG0667	Aldo Keto reductase
A8L58_14455	COG1881	PFAM PEBP family protein
A8L58_14465	COG4581	dead DEAH box helicase
A8L58_14475	COG0166	Belongs to the GPI family
A8L58_14490	COG2814	Major facilitator Superfamily
A8L58_14495	COG0656	L-ascorbic acid biosynthetic process
A8L58_14500	COG0018	arginyl-trna synthetase
A8L58_14520	COG2814	Major facilitator Superfamily
A8L58_14535	COG1012	belongs to the aldehyde dehydrogenase family
A8L58_14545	COG1070	Carbohydrate kinase
A8L58_14550	COG4952	isomerase
A8L58_14555	COG2814	Major facilitator Superfamily
A8L58_14560	COG3254	rhamnose metabolic process
A8L58_14565	COG1609	Transcriptional regulator
A8L58_14605	COG1609	Transcriptional regulator
A8L58_14615	COG0673	inositol 2-dehydrogenase activity
A8L58_14635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8L58_14645	COG1027	Aspartate ammonia-lyase
A8L58_14680	COG1309	transcriptional regulator
A8L58_14690	COG0154	amidase activity
A8L58_14695	COG4608	Belongs to the ABC transporter superfamily
A8L58_14700	COG2814	Major facilitator Superfamily
A8L58_14715	COG1131	(ABC) transporter
A8L58_14720	COG1309	transcriptional regulator
A8L58_14735	COG0676	glucose-6-phosphate 1-epimerase activity
A8L58_14740	COG0560	Phosphoserine phosphatase
A8L58_14740	COG3830	Belongs to the UPF0237 family
A8L58_14745	COG2813	Specifically methylates the guanine in position
A8L58_14750	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A8L58_14755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8L58_14755	COG0574	Belongs to the PEP-utilizing enzyme family
A8L58_14770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A8L58_14775	COG2205	protein histidine kinase activity
A8L58_14780	COG0745	RESPONSE REGULATOR receiver
A8L58_14800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A8L58_14805	COG0484	heat shock protein binding
A8L58_14810	COG0789	Transcriptional regulator
A8L58_14815	COG1063	alcohol dehydrogenase
A8L58_14820	COG3527	Alpha-acetolactate decarboxylase
A8L58_14825	COG0569	domain protein
A8L58_14825	COG2985	domain, Protein
A8L58_14830	COG1113	amino acid transport
A8L58_14840	COG0577	efflux transmembrane transporter activity
A8L58_14840	COG1136	(ABC) transporter
A8L58_14845	COG4591	ABC-type transport system involved in lipoprotein release permease component
A8L58_14845	COG1136	(ABC) transporter
A8L58_14855	COG2197	response regulator
A8L58_14860	COG4585	Histidine kinase
A8L58_14875	COG3588	fructose-bisphosphate aldolase
A8L58_14880	COG1609	Transcriptional regulator
A8L58_14890	COG2211	Major facilitator Superfamily
A8L58_14890	COG2190	(PTS) system
A8L58_14905	COG0395	ABC-type sugar transport system, permease component
A8L58_14915	COG0542	response to heat
A8L58_14920	COG0395	ABC-type sugar transport system, permease component
A8L58_14925	COG1175	transmembrane transport
A8L58_14935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8L58_14945	COG1486	melibiose metabolic process
A8L58_14960	COG1511	domain protein
A8L58_14975	COG0702	epimerase
A8L58_14990	COG0395	ABC-type sugar transport system, permease component
A8L58_14995	COG1175	transmembrane transport
A8L58_15000	COG2182	Extracellular solute-binding protein
A8L58_15005	COG1609	Transcriptional regulator
A8L58_15010	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A8L58_15020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A8L58_15055	COG0517	IMP dehydrogenase activity
A8L58_15055	COG4175	Glycine betaine
A8L58_15060	COG4176	ABC-type proline glycine betaine transport system permease component
A8L58_15080	COG1174	glycine betaine transport
A8L58_15090	COG1174	glycine betaine transport
A8L58_15105	COG0436	Aminotransferase
A8L58_15125	COG1704	LemA family
A8L58_15130	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A8L58_15130	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A8L58_15150	COG0438	transferase activity, transferring glycosyl groups
A8L58_15180	COG2244	polysaccharide biosynthetic process
A8L58_15185	COG0489	protein tyrosine kinase activity
A8L58_15205	COG0586	Pfam SNARE associated Golgi protein
A8L58_15220	COG0191	fructose-bisphosphate aldolase activity
A8L58_15250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8L58_15255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8L58_15260	COG0588	phosphoglycerate mutase activity
A8L58_15265	COG0704	Plays a role in the regulation of phosphate uptake
A8L58_15270	COG5002	protein histidine kinase activity
A8L58_15285	COG1329	Transcriptional regulator
A8L58_15290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8L58_15300	COG3775	system Galactitol-specific IIC component
A8L58_15310	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A8L58_15325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A8L58_15330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A8L58_15350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8L58_15355	COG2814	Major facilitator Superfamily
A8L58_15365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8L58_15370	COG0215	cysteine-tRNA ligase activity
A8L58_15385	COG0626	cystathionine gamma-synthase activity
A8L58_15440	COG1484	DNA-dependent DNA replication
A8L58_15450	COG3842	ATPase activity
A8L58_15465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8L58_15475	COG1760	l-serine dehydratase
A8L58_15480	COG1940	carbohydrate kinase activity
A8L58_15485	COG1653	transport
A8L58_15495	COG0395	ABC-type sugar transport system, permease component
A8L58_15500	COG1063	alcohol dehydrogenase
A8L58_15505	COG0156	8-amino-7-oxononanoate synthase activity
A8L58_15515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A8L58_15520	COG1131	(ABC) transporter
A8L58_15530	COG4585	Histidine kinase
A8L58_15535	COG2197	response regulator
A8L58_15545	COG0406	alpha-ribazole phosphatase activity
A8L58_15560	COG1131	(ABC) transporter
A8L58_15565	COG4585	Histidine kinase
A8L58_15575	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A8L58_15580	COG1492	cobalamin metabolic process
A8L58_15600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8L58_15600	COG1648	precorrin-2 dehydrogenase activity
A8L58_15615	COG0310	cobalt ion transport
A8L58_15640	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A8L58_15645	COG1797	cobyrinic acid a,c-diamide synthase activity
A8L58_15650	COG1648	precorrin-2 dehydrogenase activity
A8L58_15650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8L58_15660	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A8L58_15690	COG1854	S-ribosylhomocysteine lyase activity
A8L58_15695	COG1482	cell wall glycoprotein biosynthetic process
A8L58_15705	COG0459	protein refolding
A8L58_15820	COG0740	serine-type endopeptidase activity
A8L58_16050	COG0363	glucosamine-6-phosphate deaminase activity
A8L58_16055	COG1278	Cold shock
A8L58_16070	COG2252	PERMEase
A8L58_16095	COG1321	iron dependent repressor
A8L58_16100	COG2226	methyltransferase
A8L58_16105	COG3118	belongs to the thioredoxin family
A8L58_16110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A8L58_16115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8L58_16125	COG3718	enzyme involved in inositol metabolism
A8L58_16130	COG3962	Belongs to the TPP enzyme family
A8L58_16145	COG0673	inositol 2-dehydrogenase activity
A8L58_16150	COG2814	Major facilitator Superfamily
A8L58_16155	COG0673	inositol 2-dehydrogenase activity
A8L58_16175	COG1970	mechanosensitive ion channel activity
A8L58_16190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A8L58_16235	COG2409	Drug exporters of the RND superfamily
A8L58_16305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8L58_16325	COG1053	succinate dehydrogenase
A8L58_16330	COG1309	transcriptional regulator
A8L58_16355	COG0789	Transcriptional regulator
A8L58_16365	COG0693	protein deglycase activity
A8L58_16420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A8L58_16425	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A8L58_16435	COG2233	PERMEase
A8L58_16450	COG0084	hydrolase, TatD family'
A8L58_16455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A8L58_16460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A8L58_16465	COG1846	Transcriptional regulator
A8L58_16470	COG1309	transcriptional regulator
A8L58_16480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A8L58_16485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A8L58_16490	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A8L58_16495	COG0193	aminoacyl-tRNA hydrolase activity
A8L58_16515	COG0148	phosphopyruvate hydratase activity
A8L58_16545	COG2837	iron assimilation
A8L58_16550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8L58_16600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A8L58_16605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A8L58_16610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A8L58_16615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8L58_16635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8L58_16635	COG0072	phenylalanine-tRNA ligase activity
A8L58_16645	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism